locus-tag	class	description
H7K60_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7K60_RS00010	COG0592	DNA-directed DNA polymerase activity
H7K60_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7K60_RS00035	COG2378	regulation of single-species biofilm formation
H7K60_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K60_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
H7K60_RS00050	COG3977	Valine--pyruvate aminotransferase
H7K60_RS00065	COG2814	Major facilitator Superfamily
H7K60_RS00070	COG0745	RESPONSE REGULATOR receiver
H7K60_RS00075	COG2205	protein histidine kinase activity
H7K60_RS00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K60_RS00100	COG4191	Histidine kinase
H7K60_RS00100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K60_RS00105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K60_RS00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K60_RS00115	COG1309	transcriptional regulator
H7K60_RS00150	COG2271	Major facilitator Superfamily
H7K60_RS00175	COG0561	phosphatase activity
H7K60_RS00180	COG2267	carboxylic ester hydrolase activity
H7K60_RS00185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7K60_RS00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7K60_RS00195	COG1758	RNA polymerase activity
H7K60_RS00205	COG0859	PFAM glycosyl transferase family 9
H7K60_RS00210	COG3642	lipopolysaccharide core region biosynthetic process
H7K60_RS00250	COG0589	response to stress
H7K60_RS00255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7K60_RS00265	COG1528	Iron-storage protein
H7K60_RS00270	COG2081	HI0933 family
H7K60_RS00275	COG2223	nitrite transmembrane transporter activity
H7K60_RS00295	COG3188	usher protein
H7K60_RS00335	COG3275	phosphorelay sensor kinase activity
H7K60_RS00340	COG3279	Response regulator of the LytR AlgR family
H7K60_RS00345	COG2223	nitrite transmembrane transporter activity
H7K60_RS00350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7K60_RS00355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7K60_RS00370	COG0583	DNA-binding transcription factor activity
H7K60_RS00375	COG4206	TonB-dependent receptor
H7K60_RS00380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H7K60_RS00415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7K60_RS00420	COG2166	iron-sulfur cluster assembly
H7K60_RS00425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7K60_RS00430	COG0210	DNA helicase
H7K60_RS00440	COG3245	cytochrome
H7K60_RS00445	COG1063	alcohol dehydrogenase
H7K60_RS00450	COG0156	8-amino-7-oxononanoate synthase activity
H7K60_RS00460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K60_RS00475	COG3306	glycosyltransferase involved in LPS biosynthesis
H7K60_RS00495	COG1561	YicC-like family, N-terminal region
H7K60_RS00500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7K60_RS00505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7K60_RS00515	COG0789	Transcriptional regulator
H7K60_RS00520	COG4251	negative regulation of phosphorylation
H7K60_RS00520	COG5001	Diguanylate cyclase
H7K60_RS00520	COG3706	GGDEF domain
H7K60_RS00520	COG2203	Gaf domain
H7K60_RS00525	COG3084	Protein conserved in bacteria
H7K60_RS00535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7K60_RS00540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7K60_RS00550	COG1335	isochorismatase
H7K60_RS00560	COG1683	Conserved Protein
H7K60_RS00565	COG0204	Acyl-transferase
H7K60_RS00570	COG0204	Acyl-transferase
H7K60_RS00575	COG0606	chelatase, subunit chli
H7K60_RS00585	COG3978	acetolactate synthase activity
H7K60_RS00595	COG0129	dihydroxy-acid dehydratase activity
H7K60_RS00615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7K60_RS00620	COG0254	rRNA binding
H7K60_RS00625	COG0702	epimerase
H7K60_RS00630	COG0281	malic enzyme
H7K60_RS00640	COG2205	protein histidine kinase activity
H7K60_RS00645	COG0745	RESPONSE REGULATOR receiver
H7K60_RS00650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7K60_RS00665	COG0366	Alpha amylase catalytic
H7K60_RS00680	COG0443	Heat shock 70 kDa protein
H7K60_RS00685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K60_RS00690	COG3045	CreA protein
H7K60_RS00710	COG0174	glutamine synthetase
H7K60_RS00730	COG3842	ATPase activity
H7K60_RS00735	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K60_RS00740	COG1177	transmembrane transport
H7K60_RS00745	COG2258	MOSC domain
H7K60_RS00765	COG2050	protein possibly involved in aromatic compounds catabolism
H7K60_RS00770	COG0514	ATP-dependent DNA helicase (RecQ)
H7K60_RS00780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7K60_RS00790	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7K60_RS00795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K60_RS00805	COG2239	Acts as a magnesium transporter
H7K60_RS00810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7K60_RS00810	COG1648	precorrin-2 dehydrogenase activity
H7K60_RS00815	COG2116	formate transmembrane transporter activity
H7K60_RS00825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7K60_RS00830	COG0842	Transport permease protein
H7K60_RS00835	COG0842	Transport permease protein
H7K60_RS00840	COG1131	(ABC) transporter
H7K60_RS00845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K60_RS00860	COG0477	Major facilitator Superfamily
H7K60_RS00865	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7K60_RS00870	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7K60_RS00890	COG1595	DNA-templated transcription, initiation
H7K60_RS00895	COG3806	Anti-sigma factor
H7K60_RS00900	COG1968	undecaprenyl-diphosphatase activity
H7K60_RS00905	COG0667	Aldo Keto reductase
H7K60_RS00910	COG2017	converts alpha-aldose to the beta-anomer
H7K60_RS00915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7K60_RS00925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7K60_RS00930	COG1609	Transcriptional regulator
H7K60_RS00935	COG3250	beta-galactosidase activity
H7K60_RS00955	COG0840	transmembrane signaling receptor activity
H7K60_RS00985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7K60_RS00990	COG1288	antiporter activity
H7K60_RS00995	COG1438	arginine binding
H7K60_RS01000	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H7K60_RS01005	COG0540	Belongs to the ATCase OTCase family
H7K60_RS01025	COG0688	phosphatidylethanolamine metabolic process
H7K60_RS01035	COG3040	lipid binding
H7K60_RS01040	COG2207	Transcriptional regulator
H7K60_RS01045	COG1979	alcohol dehydrogenase
H7K60_RS01050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H7K60_RS01055	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H7K60_RS01065	COG3681	Belongs to the UPF0597 family
H7K60_RS01075	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7K60_RS01080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K60_RS01085	COG0564	pseudouridine synthase activity
H7K60_RS01095	COG0542	response to heat
H7K60_RS01100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7K60_RS01105	COG2502	aspartate--ammonia ligase
H7K60_RS01110	COG1522	sequence-specific DNA binding
H7K60_RS01120	COG5413	integral membrane protein
H7K60_RS01145	COG2205	protein histidine kinase activity
H7K60_RS01155	COG2204	response regulator
H7K60_RS01170	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H7K60_RS01200	COG0243	molybdopterin cofactor binding
H7K60_RS01205	COG3005	denitrification pathway
H7K60_RS01210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7K60_RS01230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7K60_RS01235	COG0569	domain protein
H7K60_RS01240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7K60_RS01265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7K60_RS01280	COG0250	Participates in transcription elongation, termination and antitermination
H7K60_RS01285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7K60_RS01290	COG0081	regulation of translation
H7K60_RS01295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7K60_RS01300	COG0222	ribosome binding
H7K60_RS01305	COG0085	RNA polymerase activity
H7K60_RS01310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7K60_RS01315	COG2964	Protein conserved in bacteria
H7K60_RS01320	COG0251	oxidation-reduction process
H7K60_RS01330	COG2923	Belongs to the DsrF TusC family
H7K60_RS01335	COG2168	tRNA wobble position uridine thiolation
H7K60_RS01340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7K60_RS01345	COG0049	tRNA binding
H7K60_RS01350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7K60_RS01355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7K60_RS01360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7K60_RS01395	COG2252	PERMEase
H7K60_RS01400	COG2376	Dihydroxyacetone kinase
H7K60_RS01405	COG1461	Dihydroxyacetone kinase
H7K60_RS01420	COG3284	Transcriptional regulator
H7K60_RS01425	COG0583	DNA-binding transcription factor activity
H7K60_RS01430	COG2957	Belongs to the agmatine deiminase family
H7K60_RS01445	COG0628	permease
H7K60_RS01450	COG0494	nUDIX hydrolase
H7K60_RS01475	COG0753	catalase activity
H7K60_RS01480	COG1247	-acetyltransferase
H7K60_RS01500	COG2199	diguanylate cyclase activity
H7K60_RS01500	COG2203	Gaf domain
H7K60_RS01510	COG3842	ATPase activity
H7K60_RS01520	COG1175	transmembrane transport
H7K60_RS01545	COG0583	DNA-binding transcription factor activity
H7K60_RS01555	COG1741	Belongs to the pirin family
H7K60_RS01560	COG2259	Doxx family
H7K60_RS01565	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7K60_RS01570	COG1074	ATP-dependent DNA helicase activity
H7K60_RS01575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7K60_RS01585	COG0346	lactoylglutathione lyase activity
H7K60_RS01630	COG5001	Diguanylate cyclase
H7K60_RS01630	COG3706	GGDEF domain
H7K60_RS01630	COG2203	Gaf domain
H7K60_RS01630	COG4251	negative regulation of phosphorylation
H7K60_RS01635	COG4771	TonB-dependent receptor
H7K60_RS01645	COG1278	Cold shock
H7K60_RS01680	COG0697	spore germination
H7K60_RS01770	COG0629	single-stranded DNA binding
H7K60_RS01775	COG2197	response regulator
H7K60_RS01780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7K60_RS01790	COG3047	cAMP biosynthetic process
H7K60_RS01795	COG0840	transmembrane signaling receptor activity
H7K60_RS01820	COG3135	benzoate transporter
H7K60_RS01825	COG1396	sequence-specific DNA binding
H7K60_RS01855	COG2926	Belongs to the UPF0265 family
H7K60_RS01865	COG3028	Belongs to the UPF0307 family
H7K60_RS01870	COG0312	modulator of DNA gyrase
H7K60_RS01875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7K60_RS01880	COG5007	Belongs to the BolA IbaG family
H7K60_RS01890	COG2854	intermembrane phospholipid transfer
H7K60_RS01895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7K60_RS01900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7K60_RS01905	COG1127	ABC transporter
H7K60_RS01910	COG0517	IMP dehydrogenase activity
H7K60_RS01910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7K60_RS01915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7K60_RS01920	COG3117	lipopolysaccharide transmembrane transporter activity
H7K60_RS01925	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7K60_RS01930	COG1137	ATPase activity
H7K60_RS01935	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7K60_RS01945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K60_RS01950	COG1660	Displays ATPase and GTPase activities
H7K60_RS01955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K60_RS01960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K60_RS01960	COG3711	transcriptional antiterminator
H7K60_RS01975	COG3964	amidohydrolase
H7K60_RS02005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K60_RS02010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7K60_RS02020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7K60_RS02025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7K60_RS02030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7K60_RS02035	COG0723	plastoquinol--plastocyanin reductase activity
H7K60_RS02040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7K60_RS02045	COG2857	Cytochrome c1
H7K60_RS02050	COG0625	glutathione transferase activity
H7K60_RS02055	COG2969	positive regulation of protein catabolic process
H7K60_RS02060	COG2823	Periplasmic or secreted lipoprotein
H7K60_RS02065	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7K60_RS02070	COG0792	nuclease activity
H7K60_RS02075	COG3107	peptidoglycan biosynthetic process
H7K60_RS02080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7K60_RS02090	COG2001	Belongs to the MraZ family
H7K60_RS02095	COG0275	rRNA processing
H7K60_RS02100	COG3116	cell division
H7K60_RS02105	COG0768	penicillin binding
H7K60_RS02115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7K60_RS02120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7K60_RS02125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7K60_RS02130	COG0772	Belongs to the SEDS family
H7K60_RS02135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7K60_RS02140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7K60_RS02145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H7K60_RS02150	COG0849	cell division
H7K60_RS02155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7K60_RS02160	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7K60_RS02170	COG0653	protein targeting
H7K60_RS02180	COG0494	nUDIX hydrolase
H7K60_RS02185	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H7K60_RS02190	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H7K60_RS02205	COG1459	type II secretion system
H7K60_RS02210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7K60_RS02235	COG2186	Transcriptional regulator
H7K60_RS02240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7K60_RS02245	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7K60_RS02250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7K60_RS02260	COG0840	transmembrane signaling receptor activity
H7K60_RS02265	COG0840	transmembrane signaling receptor activity
H7K60_RS02270	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7K60_RS02275	COG1049	propionate catabolic process, 2-methylcitrate cycle
H7K60_RS02280	COG2200	EAL domain
H7K60_RS02290	COG1280	lysine exporter protein (LysE YggA)
H7K60_RS02300	COG0523	cobalamin synthesis protein
H7K60_RS02305	COG0477	Major facilitator Superfamily
H7K60_RS02320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7K60_RS02325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7K60_RS02370	COG0784	Response regulator, receiver
H7K60_RS02370	COG0835	chemotaxis
H7K60_RS02380	COG1444	tRNA N-acetyltransferase activity
H7K60_RS02405	COG1803	Methylglyoxal synthase
H7K60_RS02420	COG0252	asparaginase activity
H7K60_RS02440	COG1263	PTS System
H7K60_RS02440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7K60_RS02445	COG0366	Alpha amylase catalytic
H7K60_RS02450	COG0110	maltose O-acetyltransferase activity
H7K60_RS02455	COG1522	sequence-specific DNA binding
H7K60_RS02460	COG5006	permease, DMT superfamily
H7K60_RS02470	COG1012	belongs to the aldehyde dehydrogenase family
H7K60_RS02475	COG1177	transmembrane transport
H7K60_RS02480	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7K60_RS02485	COG3842	ATPase activity
H7K60_RS02490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7K60_RS02495	COG0583	DNA-binding transcription factor activity
H7K60_RS02500	COG1757	Na H antiporter
H7K60_RS02540	COG0297	glycogen (starch) synthase activity
H7K60_RS02545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7K60_RS02550	COG2813	Specifically methylates the guanine in position
H7K60_RS02555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7K60_RS02560	COG2203	Gaf domain
H7K60_RS02560	COG3706	GGDEF domain
H7K60_RS02560	COG4251	negative regulation of phosphorylation
H7K60_RS02560	COG5001	Diguanylate cyclase
H7K60_RS02570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K60_RS02580	COG2995	paraquat-inducible protein a
H7K60_RS02585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7K60_RS02585	COG3008	intermembrane lipid transfer
H7K60_RS02590	COG3009	Protein conserved in bacteria
H7K60_RS02595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7K60_RS02595	COG2885	chlorophyll binding
H7K60_RS02605	COG3240	lipase activity
H7K60_RS02610	COG3111	PFAM Bacterial OB fold (BOF) protein
H7K60_RS02620	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H7K60_RS02625	COG1194	a g-specific adenine glycosylase
H7K60_RS02635	COG3267	Type II secretory pathway component ExeA
H7K60_RS02635	COG3409	Peptidoglycan-binding domain 1 protein
H7K60_RS02640	COG0617	tRNA 3'-terminal CCA addition
H7K60_RS02655	COG1346	cytolysis
H7K60_RS02660	COG1380	Effector of murein hydrolase LrgA
H7K60_RS02665	COG0583	DNA-binding transcription factor activity
H7K60_RS02695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7K60_RS02700	COG0306	phosphate transporter
H7K60_RS02705	COG1392	Phosphate transport regulator
H7K60_RS02720	COG1560	Kdo2-lipid A biosynthetic process
H7K60_RS02725	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7K60_RS02725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7K60_RS02730	COG1538	Outer membrane efflux protein
H7K60_RS02735	COG0494	nUDIX hydrolase
H7K60_RS02740	COG3151	Protein conserved in bacteria
H7K60_RS02750	COG3150	esterase
H7K60_RS02755	COG1051	belongs to the nudix hydrolase family
H7K60_RS02770	COG1566	PFAM secretion protein HlyD family protein
H7K60_RS02775	COG1289	transmembrane transporter activity
H7K60_RS02780	COG0187	DNA topoisomerase II activity
H7K60_RS02800	COG0583	DNA-binding transcription factor activity
H7K60_RS02845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7K60_RS02870	COG0204	Acyl-transferase
H7K60_RS02875	COG1842	Phage shock protein A
H7K60_RS02890	COG2827	Endonuclease containing a URI domain
H7K60_RS02900	COG2962	Rard protein
H7K60_RS02905	COG1573	uracil-dna glycosylase
H7K60_RS02910	COG0697	spore germination
H7K60_RS02915	COG0583	DNA-binding transcription factor activity
H7K60_RS02920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7K60_RS02925	COG1121	(ABC) transporter
H7K60_RS02930	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H7K60_RS02950	COG0739	heme binding
H7K60_RS02960	COG3068	Protein conserved in bacteria
H7K60_RS02980	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7K60_RS02985	COG1546	Belongs to the CinA family
H7K60_RS02990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7K60_RS03000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7K60_RS03005	COG0527	aspartate kinase activity
H7K60_RS03010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7K60_RS03050	COG1686	Belongs to the peptidase S11 family
H7K60_RS03055	COG0586	Pfam SNARE associated Golgi protein
H7K60_RS03060	COG1253	flavin adenine dinucleotide binding
H7K60_RS03065	COG0525	valine-tRNA ligase activity
H7K60_RS03070	COG2927	DNA polymerase III (CHI subunit)
H7K60_RS03075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7K60_RS03080	COG0795	lipopolysaccharide-transporting ATPase activity
H7K60_RS03085	COG0795	lipopolysaccharide-transporting ATPase activity
H7K60_RS03225	COG4695	Portal protein
H7K60_RS03305	COG2932	Transcriptional regulator
H7K60_RS03315	COG4974	Belongs to the 'phage' integrase family
H7K60_RS03320	COG0582	viral genome integration into host DNA
H7K60_RS03350	COG1196	nuclear chromosome segregation
H7K60_RS03360	COG0004	ammonium transporteR
H7K60_RS03365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7K60_RS03375	COG2165	general secretion pathway protein
H7K60_RS03380	COG0084	hydrolase, TatD family'
H7K60_RS03385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7K60_RS03395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7K60_RS03400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7K60_RS03405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H7K60_RS03410	COG0813	purine-nucleoside phosphorylase activity
H7K60_RS03415	COG3447	MASE1 domain protein
H7K60_RS03415	COG5001	Diguanylate cyclase
H7K60_RS03415	COG5002	protein histidine kinase activity
H7K60_RS03425	COG0560	Phosphoserine phosphatase
H7K60_RS03450	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H7K60_RS03460	COG0776	regulation of translation
H7K60_RS03475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7K60_RS03480	COG0735	belongs to the Fur family
H7K60_RS03505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7K60_RS03510	COG0513	Belongs to the DEAD box helicase family
H7K60_RS03515	COG3022	response to hydroperoxide
H7K60_RS03530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7K60_RS03535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7K60_RS03540	COG0762	integral membrane protein
H7K60_RS03545	COG1872	DUF167
H7K60_RS03560	COG4166	transmembrane transport
H7K60_RS03580	COG1024	Enoyl-CoA hydratase
H7K60_RS03595	COG4221	oxidoreductase activity
H7K60_RS03600	COG0442	prolyl-tRNA aminoacylation
H7K60_RS03605	COG0840	transmembrane signaling receptor activity
H7K60_RS03610	COG0632	four-way junction helicase activity
H7K60_RS03615	COG2255	four-way junction helicase activity
H7K60_RS03620	COG1271	oxidase subunit
H7K60_RS03625	COG1294	oxidase, subunit
H7K60_RS03630	COG4890	Cyd operon protein YbgT
H7K60_RS03635	COG3790	cyd operon protein YbgE
H7K60_RS03640	COG0824	Thioesterase
H7K60_RS03645	COG0811	peptide transport
H7K60_RS03660	COG0823	Involved in the tonB-independent uptake of proteins
H7K60_RS03665	COG2885	chlorophyll binding
H7K60_RS03670	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H7K60_RS03745	COG0840	transmembrane signaling receptor activity
H7K60_RS03750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7K60_RS03755	COG0676	glucose-6-phosphate 1-epimerase activity
H7K60_RS03760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7K60_RS03765	COG1640	4-alpha-glucanotransferase
H7K60_RS03770	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7K60_RS03790	COG1051	belongs to the nudix hydrolase family
H7K60_RS03795	COG2130	NADP-dependent
H7K60_RS03800	COG1764	response to oxidative stress
H7K60_RS03805	COG1846	Transcriptional regulator
H7K60_RS03840	COG0561	phosphatase activity
H7K60_RS03855	COG0733	neurotransmitter:sodium symporter activity
H7K60_RS03865	COG0733	neurotransmitter:sodium symporter activity
H7K60_RS03890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K60_RS03905	COG1794	racemase activity, acting on amino acids and derivatives
H7K60_RS03920	COG2731	YhcH YjgK YiaL family protein
H7K60_RS03930	COG0668	transmembrane transport
H7K60_RS03940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7K60_RS03975	COG0583	DNA-binding transcription factor activity
H7K60_RS03980	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7K60_RS03990	COG0488	(ABC) transporter
H7K60_RS03995	COG0517	IMP dehydrogenase activity
H7K60_RS03995	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7K60_RS04000	COG1585	Membrane protein implicated in regulation of membrane protease activity
H7K60_RS04005	COG0330	HflC and HflK could
H7K60_RS04010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7K60_RS04010	COG1648	precorrin-2 dehydrogenase activity
H7K60_RS04015	COG0175	sulfate reduction
H7K60_RS04020	COG2895	sulfate adenylyltransferase (ATP) activity
H7K60_RS04025	COG3273	potassium ion transport
H7K60_RS04025	COG0471	metal ion transport
H7K60_RS04030	COG0529	Catalyzes the synthesis of activated sulfate
H7K60_RS04065	COG0840	transmembrane signaling receptor activity
H7K60_RS04085	COG1136	(ABC) transporter
H7K60_RS04100	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H7K60_RS04115	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7K60_RS04120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7K60_RS04125	COG0163	prenyltransferase activity
H7K60_RS04140	COG1131	(ABC) transporter
H7K60_RS04145	COG0842	Transport permease protein
H7K60_RS04150	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
H7K60_RS04155	COG1924	4 iron, 4 sulfur cluster binding
H7K60_RS04175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7K60_RS04180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7K60_RS04195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7K60_RS04200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7K60_RS04205	COG1489	DNA binding
H7K60_RS04215	COG1643	Atp-dependent helicase
H7K60_RS04220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7K60_RS04225	COG0346	lactoylglutathione lyase activity
H7K60_RS04235	COG2076	Multidrug Resistance protein
H7K60_RS04245	COG3437	response regulator, receiver
H7K60_RS04245	COG0784	Response regulator, receiver
H7K60_RS04255	COG0671	phosphoesterase, PA-phosphatase related
H7K60_RS04270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7K60_RS04275	COG0038	chloride channel
H7K60_RS04285	COG0316	Belongs to the HesB IscA family
H7K60_RS04315	COG1280	lysine exporter protein (LysE YggA)
H7K60_RS04320	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7K60_RS04335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K60_RS04365	COG0745	RESPONSE REGULATOR receiver
H7K60_RS04370	COG3104	oligopeptide transport
H7K60_RS04375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7K60_RS04380	COG1555	photosystem II stabilization
H7K60_RS04390	COG2350	Protein conserved in bacteria
H7K60_RS04395	COG2917	probably involved in intracellular septation
H7K60_RS04400	COG0076	glutamate decarboxylase activity
H7K60_RS04405	COG1272	protein, Hemolysin III
H7K60_RS04410	COG2985	domain, Protein
H7K60_RS04410	COG0569	domain protein
H7K60_RS04425	COG0835	chemotaxis
H7K60_RS04425	COG0784	Response regulator, receiver
H7K60_RS04430	COG2755	lipolytic protein G-D-S-L family
H7K60_RS04435	COG4181	ATPase activity
H7K60_RS04440	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H7K60_RS04445	COG1090	epimerase
H7K60_RS04450	COG2200	EAL domain
H7K60_RS04455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K60_RS04460	COG2234	aminopeptidase activity
H7K60_RS04460	COG4935	Belongs to the peptidase S8 family
H7K60_RS04465	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7K60_RS04470	COG3171	Protein conserved in bacteria
H7K60_RS04475	COG2066	Belongs to the glutaminase family
H7K60_RS04480	COG2897	thiosulfate sulfurtransferase activity
H7K60_RS04490	COG1132	(ABC) transporter
H7K60_RS04510	COG0582	viral genome integration into host DNA
H7K60_RS04535	COG4735	regulation of single-species biofilm formation
H7K60_RS04545	COG4974	Belongs to the 'phage' integrase family
H7K60_RS04580	COG0783	Belongs to the Dps family
H7K60_RS04590	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7K60_RS04605	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7K60_RS04620	COG1342	Belongs to the UPF0251 family
H7K60_RS04625	COG0582	viral genome integration into host DNA
H7K60_RS04635	COG4974	Belongs to the 'phage' integrase family
H7K60_RS04685	COG0582	viral genome integration into host DNA
H7K60_RS04690	COG4584	PFAM Integrase catalytic
H7K60_RS04695	COG1484	DNA-dependent DNA replication
H7K60_RS04740	COG4974	Belongs to the 'phage' integrase family
H7K60_RS04795	COG3335	DDE superfamily endonuclease
H7K60_RS04805	COG1609	Transcriptional regulator
H7K60_RS04810	COG1263	PTS System
H7K60_RS04810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7K60_RS04810	COG2190	(PTS) system
H7K60_RS04825	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
H7K60_RS04830	COG3300	MHYT domain
H7K60_RS04830	COG5001	Diguanylate cyclase
H7K60_RS04840	COG2207	Transcriptional regulator
H7K60_RS04845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K60_RS04850	COG3059	membrane
H7K60_RS04865	COG4628	conserved protein (DUF2132)
H7K60_RS04870	COG0688	phosphatidylethanolamine metabolic process
H7K60_RS04875	COG1162	GTPase activity
H7K60_RS04880	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7K60_RS04920	COG1278	Cold shock
H7K60_RS04930	COG0840	transmembrane signaling receptor activity
H7K60_RS04935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7K60_RS04985	COG0848	biopolymer transport protein
H7K60_RS04990	COG0811	peptide transport
H7K60_RS04995	COG0811	peptide transport
H7K60_RS05010	COG4174	ABC transporter (Permease)
H7K60_RS05015	COG4239	(ABC) transporter, permease
H7K60_RS05025	COG0444	Belongs to the ABC transporter superfamily
H7K60_RS05030	COG4608	Belongs to the ABC transporter superfamily
H7K60_RS05035	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7K60_RS05040	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H7K60_RS05045	COG1073	alpha beta
H7K60_RS05060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7K60_RS05085	COG0243	molybdopterin cofactor binding
H7K60_RS05100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7K60_RS05100	COG1116	anion transmembrane transporter activity
H7K60_RS05105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7K60_RS05110	COG1116	anion transmembrane transporter activity
H7K60_RS05115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7K60_RS05115	COG2146	nitrite reductase [NAD(P)H] activity
H7K60_RS05120	COG2146	nitrite reductase [NAD(P)H] activity
H7K60_RS05120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7K60_RS05125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K60_RS05130	COG2313	pseudouridylate synthase activity
H7K60_RS05140	COG1858	cytochrome C peroxidase
H7K60_RS05175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K60_RS05180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K60_RS05195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K60_RS05240	COG1028	Short-chain dehydrogenase reductase Sdr
H7K60_RS05245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7K60_RS05255	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7K60_RS05270	COG2966	Psort location CytoplasmicMembrane, score
H7K60_RS05275	COG3610	response to peptide
H7K60_RS05285	COG4175	Glycine betaine
H7K60_RS05290	COG4176	ABC-type proline glycine betaine transport system permease component
H7K60_RS05295	COG2113	Glycine betaine
H7K60_RS05300	COG0175	sulfate reduction
H7K60_RS05305	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7K60_RS05310	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7K60_RS05315	COG0384	phenazine biosynthesis protein PhzF
H7K60_RS05320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7K60_RS05335	COG0786	glutamate:sodium symporter activity
H7K60_RS05340	COG0252	asparaginase activity
H7K60_RS05345	COG3139	Protein of unknown function (DUF1315)
H7K60_RS05365	COG0616	signal peptide processing
H7K60_RS05370	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7K60_RS05370	COG1902	pentaerythritol trinitrate reductase activity
H7K60_RS05375	COG0778	Nitroreductase
H7K60_RS05395	COG2264	protein methyltransferase activity
H7K60_RS05400	COG0604	alcohol dehydrogenase
H7K60_RS05405	COG0583	DNA-binding transcription factor activity
H7K60_RS05410	COG1263	PTS System
H7K60_RS05410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7K60_RS05410	COG2190	(PTS) system
H7K60_RS05415	COG4145	pantothenate transmembrane transporter activity
H7K60_RS05425	COG0439	Biotin carboxylase
H7K60_RS05430	COG0511	ligase activity, forming carbon-carbon bonds
H7K60_RS05435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7K60_RS05440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K60_RS05450	COG5001	Diguanylate cyclase
H7K60_RS05450	COG3300	MHYT domain
H7K60_RS05470	COG3381	protein complex oligomerization
H7K60_RS05485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7K60_RS05495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7K60_RS05500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7K60_RS05500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7K60_RS05520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7K60_RS05525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7K60_RS05530	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7K60_RS05535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7K60_RS05540	COG4172	Belongs to the ABC transporter superfamily
H7K60_RS05550	COG0601	transmembrane transport
H7K60_RS05560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7K60_RS05565	COG0142	geranyltranstransferase activity
H7K60_RS05570	COG1722	exodeoxyribonuclease VII activity
H7K60_RS05575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7K60_RS05580	COG1360	Flagellar Motor Protein
H7K60_RS05595	COG1534	Rna-binding protein
H7K60_RS05600	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7K60_RS05610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7K60_RS05615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7K60_RS05620	COG0149	triose-phosphate isomerase activity
H7K60_RS05625	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7K60_RS05640	COG0779	Required for maturation of 30S ribosomal subunits
H7K60_RS05645	COG0195	Participates in both transcription termination and antitermination
H7K60_RS05650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7K60_RS05655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7K60_RS05660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7K60_RS05665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7K60_RS05670	COG1185	polyribonucleotide nucleotidyltransferase activity
H7K60_RS05675	COG2211	Major facilitator Superfamily
H7K60_RS05685	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7K60_RS05695	COG0114	fumarate hydratase activity
H7K60_RS05705	COG1966	Carbon starvation protein
H7K60_RS05710	COG3279	Response regulator of the LytR AlgR family
H7K60_RS05715	COG3275	phosphorelay sensor kinase activity
H7K60_RS05780	COG0312	modulator of DNA gyrase
H7K60_RS05785	COG0312	modulator of DNA gyrase
H7K60_RS05795	COG4974	Belongs to the 'phage' integrase family
H7K60_RS05805	COG1970	mechanosensitive ion channel activity
H7K60_RS05810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7K60_RS05820	COG0789	Transcriptional regulator
H7K60_RS05835	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7K60_RS05840	COG3545	Serine hydrolase
H7K60_RS05850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7K60_RS05855	COG0321	lipoyl(octanoyl) transferase activity
H7K60_RS05860	COG2921	Belongs to the UPF0250 family
H7K60_RS05865	COG1686	Belongs to the peptidase S11 family
H7K60_RS05870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7K60_RS05875	COG2951	lytic endotransglycosylase activity
H7K60_RS05880	COG0772	Belongs to the SEDS family
H7K60_RS05885	COG0772	Belongs to the SEDS family
H7K60_RS05890	COG0768	penicillin binding
H7K60_RS05895	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7K60_RS05900	COG0799	negative regulation of ribosome biogenesis
H7K60_RS05905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7K60_RS05920	COG0495	leucyl-tRNA aminoacylation
H7K60_RS05925	COG2888	peptidyl-tyrosine sulfation
H7K60_RS05930	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7K60_RS05935	COG4535	Mg2 and Co2 transporter CorC
H7K60_RS05940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7K60_RS05945	COG1702	phosphate starvation-inducible protein PhoH
H7K60_RS05950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7K60_RS05955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K60_RS05960	COG1335	isochorismatase
H7K60_RS05970	COG3706	GGDEF domain
H7K60_RS05985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K60_RS06005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7K60_RS06015	COG3647	Membrane
H7K60_RS06020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7K60_RS06030	COG0516	GMP reductase activity
H7K60_RS06040	COG0642	Histidine kinase
H7K60_RS06080	COG3214	Protein conserved in bacteria
H7K60_RS06105	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7K60_RS06110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7K60_RS06115	COG1053	succinate dehydrogenase
H7K60_RS06125	COG0584	glycerophosphoryl diester phosphodiesterase
H7K60_RS06130	COG1511	domain protein
H7K60_RS06130	COG3264	Mechanosensitive ion channel
H7K60_RS06155	COG0583	DNA-binding transcription factor activity
H7K60_RS06175	COG0583	DNA-binding transcription factor activity
H7K60_RS06180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7K60_RS06210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7K60_RS06215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7K60_RS06225	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H7K60_RS06235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7K60_RS06245	COG0180	Tryptophanyl-tRNA synthetase
H7K60_RS06260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7K60_RS06270	COG1012	belongs to the aldehyde dehydrogenase family
H7K60_RS06280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K60_RS06290	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7K60_RS06290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K60_RS06290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7K60_RS06290	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7K60_RS06300	COG0488	(ABC) transporter
H7K60_RS06310	COG0366	Alpha amylase catalytic
H7K60_RS06340	COG0471	metal ion transport
H7K60_RS06340	COG0490	domain, Protein
H7K60_RS06385	COG0012	GTP binding
H7K60_RS06390	COG0193	aminoacyl-tRNA hydrolase activity
H7K60_RS06395	COG0737	Belongs to the 5'-nucleotidase family
H7K60_RS06400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7K60_RS06410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7K60_RS06415	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H7K60_RS06420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7K60_RS06425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7K60_RS06430	COG2890	protein-(glutamine-N5) methyltransferase activity
H7K60_RS06440	COG2912	Transglutaminase-like superfamily
H7K60_RS06445	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7K60_RS06450	COG1301	dicarboxylic acid transport
H7K60_RS06460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7K60_RS06475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7K60_RS06480	COG1115	amino acid carrier protein
H7K60_RS06495	COG0714	Associated with various cellular activities
H7K60_RS06525	COG3104	oligopeptide transport
H7K60_RS06530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7K60_RS06535	COG1678	Uncharacterized ACR, COG1678
H7K60_RS06545	COG0189	ligase activity
H7K60_RS06550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7K60_RS06560	COG3091	SprT-like family
H7K60_RS06570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7K60_RS06585	COG3385	transposase activity
H7K60_RS06595	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7K60_RS06600	COG0739	heme binding
H7K60_RS06605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7K60_RS06610	COG3408	Glycogen debranching enzyme
H7K60_RS06610	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H7K60_RS06620	COG1881	PFAM PEBP family protein
H7K60_RS06625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7K60_RS06630	COG0583	DNA-binding transcription factor activity
H7K60_RS06640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7K60_RS06650	COG0583	DNA-binding transcription factor activity
H7K60_RS06655	COG1028	Short-chain dehydrogenase reductase Sdr
H7K60_RS06660	COG0616	signal peptide processing
H7K60_RS06665	COG3724	N-succinylarginine dihydrolase activity
H7K60_RS06685	COG0840	transmembrane signaling receptor activity
H7K60_RS06695	COG2971	BadF BadG BcrA BcrD
H7K60_RS06705	COG4608	Belongs to the ABC transporter superfamily
H7K60_RS06710	COG0444	Belongs to the ABC transporter superfamily
H7K60_RS06715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K60_RS06720	COG0601	transmembrane transport
H7K60_RS06725	COG4166	transmembrane transport
H7K60_RS06730	COG0784	Response regulator, receiver
H7K60_RS06730	COG2205	protein histidine kinase activity
H7K60_RS06760	COG3220	belongs to the UPF0276 family
H7K60_RS06790	COG1289	transmembrane transporter activity
H7K60_RS06795	COG0303	'Molybdopterin
H7K60_RS06800	COG0746	molybdenum cofactor guanylyltransferase activity
H7K60_RS06810	COG4662	Binding-protein-dependent transport system inner membrane component
H7K60_RS06825	COG3852	Histidine kinase
H7K60_RS06830	COG1910	domain protein
H7K60_RS06835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7K60_RS06870	COG3383	formate dehydrogenase (NAD+) activity
H7K60_RS06870	COG3383	formate dehydrogenase (NAD+) activity
H7K60_RS06875	COG0437	4 iron, 4 sulfur cluster binding
H7K60_RS06890	COG0281	malic enzyme
H7K60_RS06910	COG2706	6-phosphogluconolactonase activity
H7K60_RS06920	COG3264	Mechanosensitive ion channel
H7K60_RS06920	COG1196	nuclear chromosome segregation
H7K60_RS06925	COG0469	pyruvate kinase activity
H7K60_RS06940	COG4651	solute:proton antiporter activity
H7K60_RS06940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7K60_RS06950	COG2974	May be involved in recombination
H7K60_RS06960	COG0420	3'-5' exonuclease activity
H7K60_RS06970	COG3038	cytochrome b561
H7K60_RS06985	COG2190	(PTS) system
H7K60_RS06995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K60_RS07000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7K60_RS07005	COG0542	response to heat
H7K60_RS07020	COG1720	tRNA m6t6A37 methyltransferase activity
H7K60_RS07040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7K60_RS07045	COG4988	ABC transporter
H7K60_RS07060	COG0745	RESPONSE REGULATOR receiver
H7K60_RS07070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7K60_RS07085	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H7K60_RS07090	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7K60_RS07100	COG0083	homoserine kinase activity
H7K60_RS07105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7K60_RS07115	COG0488	(ABC) transporter
H7K60_RS07120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7K60_RS07125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7K60_RS07145	COG0813	purine-nucleoside phosphorylase activity
H7K60_RS07160	COG2205	protein histidine kinase activity
H7K60_RS07160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K60_RS07165	COG3384	dioxygenase
H7K60_RS07175	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7K60_RS07185	COG0531	amino acid
H7K60_RS07195	COG0531	amino acid
H7K60_RS07210	COG1917	Cupin 2, conserved barrel domain protein
H7K60_RS07210	COG1396	sequence-specific DNA binding
H7K60_RS07215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K60_RS07235	COG3152	Membrane
H7K60_RS07260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7K60_RS07265	COG2375	cellular response to nickel ion
H7K60_RS07275	COG0577	efflux transmembrane transporter activity
H7K60_RS07275	COG1136	(ABC) transporter
H7K60_RS07280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K60_RS07290	COG1227	inorganic diphosphatase activity
H7K60_RS07295	COG0497	DNA recombination
H7K60_RS07300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7K60_RS07305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7K60_RS07310	COG0443	Heat shock 70 kDa protein
H7K60_RS07315	COG0484	heat shock protein binding
H7K60_RS07345	COG1285	pathogenesis
H7K60_RS07360	COG0640	Transcriptional regulator
H7K60_RS07390	COG0095	Lipoate-protein ligase
H7K60_RS07410	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K60_RS07415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K60_RS07435	COG0708	Exodeoxyribonuclease III
H7K60_RS07450	COG2211	Major facilitator Superfamily
H7K60_RS07495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7K60_RS07505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7K60_RS07510	COG1845	cytochrome c oxidase, subunit III
H7K60_RS07515	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7K60_RS07520	COG0109	protoheme IX farnesyltransferase activity
H7K60_RS07525	COG2814	Major facilitator Superfamily
H7K60_RS07550	COG3152	Membrane
H7K60_RS07560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7K60_RS07580	COG1988	membrane-bound metal-dependent
H7K60_RS07595	COG0159	tryptophan synthase activity
H7K60_RS07600	COG0133	tryptophan synthase activity
H7K60_RS07605	COG0134	indole-3-glycerol-phosphate synthase activity
H7K60_RS07605	COG0135	phosphoribosylanthranilate isomerase activity
H7K60_RS07610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7K60_RS07615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7K60_RS07615	COG0512	Glutamine amidotransferase of anthranilate synthase
H7K60_RS07620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7K60_RS07630	COG0009	L-threonylcarbamoyladenylate synthase
H7K60_RS07640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7K60_RS07650	COG1946	Acyl-CoA thioesterase
H7K60_RS07670	COG1309	transcriptional regulator
H7K60_RS07675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K60_RS07680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K60_RS07695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7K60_RS07700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7K60_RS07700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K60_RS07705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7K60_RS07735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7K60_RS07745	COG1091	dTDP-4-dehydrorhamnose reductase activity
H7K60_RS07755	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H7K60_RS07765	COG3132	Protein of unknown function, DUF480
H7K60_RS07810	COG1278	Cold shock
H7K60_RS07835	COG4166	transmembrane transport
H7K60_RS07840	COG0697	spore germination
H7K60_RS07845	COG1349	DNA-binding transcription factor activity
H7K60_RS07850	COG1882	Formate acetyltransferase
H7K60_RS07855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7K60_RS07860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7K60_RS07890	COG0622	Phosphoesterase
H7K60_RS07905	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H7K60_RS07910	COG0784	Response regulator, receiver
H7K60_RS07910	COG0835	chemotaxis
H7K60_RS07915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7K60_RS07920	COG1815	bacterial-type flagellum-dependent cell motility
H7K60_RS07940	COG4787	bacterial-type flagellum-dependent cell motility
H7K60_RS07950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7K60_RS07955	COG1706	bacterial-type flagellum-dependent cell motility
H7K60_RS07960	COG3951	Flagellar rod assembly protein muramidase FlgJ
H7K60_RS07960	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7K60_RS07965	COG1256	bacterial-type flagellum assembly
H7K60_RS07975	COG2239	Acts as a magnesium transporter
H7K60_RS07985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7K60_RS07990	COG2716	regulation of RNA biosynthetic process
H7K60_RS08015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7K60_RS08020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7K60_RS08025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7K60_RS08030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7K60_RS08050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7K60_RS08065	COG0590	tRNA wobble adenosine to inosine editing
H7K60_RS08070	COG0573	inorganic phosphate transmembrane transporter activity
H7K60_RS08075	COG0581	inorganic phosphate transmembrane transporter activity
H7K60_RS08080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7K60_RS08085	COG0704	Plays a role in the regulation of phosphate uptake
H7K60_RS08090	COG1253	flavin adenine dinucleotide binding
H7K60_RS08105	COG0531	amino acid
H7K60_RS08125	COG1126	abc transporter atp-binding protein
H7K60_RS08130	COG0765	amino acid transport
H7K60_RS08135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K60_RS08145	COG2271	Major facilitator Superfamily
H7K60_RS08160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7K60_RS08185	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7K60_RS08190	COG0477	Major facilitator Superfamily
H7K60_RS08195	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7K60_RS08205	COG1199	ATP-dependent helicase activity
H7K60_RS08220	COG1448	Aminotransferase
H7K60_RS08225	COG0433	COG0433 Predicted ATPase
H7K60_RS08240	COG0658	competence protein
H7K60_RS08240	COG2333	competence protein COMEC
H7K60_RS08250	COG1663	tetraacyldisaccharide 4'-kinase activity
H7K60_RS08255	COG2835	tetraacyldisaccharide 4'-kinase activity
H7K60_RS08260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7K60_RS08265	COG2197	response regulator
H7K60_RS08270	COG0322	excinuclease ABC activity
H7K60_RS08330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7K60_RS08340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7K60_RS08365	COG2199	diguanylate cyclase activity
H7K60_RS08365	COG2203	Gaf domain
H7K60_RS08395	COG2119	membrane
H7K60_RS08400	COG0023	Translation Initiation Factor
H7K60_RS08425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7K60_RS08440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K60_RS08440	COG2205	protein histidine kinase activity
H7K60_RS08450	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H7K60_RS08460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7K60_RS08465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7K60_RS08470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K60_RS08475	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7K60_RS08480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7K60_RS08490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7K60_RS08495	COG0505	Belongs to the CarA family
H7K60_RS08500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7K60_RS08505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7K60_RS08540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7K60_RS08545	COG0513	Belongs to the DEAD box helicase family
H7K60_RS08555	COG4104	PAAR repeat-containing protein
H7K60_RS08570	COG0789	Transcriptional regulator
H7K60_RS08585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K60_RS08590	COG0765	amino acid transport
H7K60_RS08595	COG1126	abc transporter atp-binding protein
H7K60_RS08600	COG0493	'glutamate synthase
H7K60_RS08605	COG0070	glutamate synthase
H7K60_RS08605	COG0069	glutamate synthase activity
H7K60_RS08605	COG0067	glutamate synthase
H7K60_RS08610	COG1242	4 iron, 4 sulfur cluster binding
H7K60_RS08685	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7K60_RS08690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7K60_RS08690	COG0574	Belongs to the PEP-utilizing enzyme family
H7K60_RS08730	COG1464	Belongs to the NlpA lipoprotein family
H7K60_RS08735	COG0671	phosphoesterase, PA-phosphatase related
H7K60_RS08740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7K60_RS08745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7K60_RS08755	COG0101	tRNA pseudouridine synthase activity
H7K60_RS08760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7K60_RS08765	COG0285	dihydrofolate synthase activity
H7K60_RS08770	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H7K60_RS08775	COG2920	part of a sulfur-relay system
H7K60_RS08780	COG1289	transmembrane transporter activity
H7K60_RS08785	COG0670	Belongs to the BI1 family
H7K60_RS08805	COG2194	sulfuric ester hydrolase activity
H7K60_RS08815	COG0392	lysyltransferase activity
H7K60_RS08815	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7K60_RS08825	COG0840	transmembrane signaling receptor activity
H7K60_RS08830	COG5001	Diguanylate cyclase
H7K60_RS08835	COG0564	pseudouridine synthase activity
H7K60_RS08850	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7K60_RS08860	COG0625	glutathione transferase activity
H7K60_RS08865	COG0625	glutathione transferase activity
H7K60_RS08875	COG0367	asparagine synthase
H7K60_RS08885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7K60_RS08885	COG4651	solute:proton antiporter activity
H7K60_RS08890	COG0647	UMP catabolic process
H7K60_RS08900	COG1902	pentaerythritol trinitrate reductase activity
H7K60_RS08905	COG1253	flavin adenine dinucleotide binding
H7K60_RS08915	COG0247	lactate metabolic process
H7K60_RS08915	COG0277	FAD linked oxidase domain protein
H7K60_RS08925	COG2050	protein possibly involved in aromatic compounds catabolism
H7K60_RS08935	COG2056	Na+-H+ antiporter family
H7K60_RS08940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7K60_RS08955	COG0346	lactoylglutathione lyase activity
H7K60_RS08960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7K60_RS08965	COG4660	Part of a membrane complex involved in electron transport
H7K60_RS08970	COG4659	FMN binding
H7K60_RS08975	COG4658	electron transport chain
H7K60_RS08985	COG2878	Part of a membrane complex involved in electron transport
H7K60_RS08990	COG4657	Part of a membrane complex involved in electron transport
H7K60_RS08995	COG0697	spore germination
H7K60_RS09010	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7K60_RS09015	COG1288	antiporter activity
H7K60_RS09020	COG0436	Aminotransferase
H7K60_RS09030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7K60_RS09035	COG2027	D-alanyl-D-alanine carboxypeptidase
H7K60_RS09040	COG1061	Type III restriction enzyme res subunit
H7K60_RS09045	COG1566	PFAM secretion protein HlyD family protein
H7K60_RS09055	COG1966	Carbon starvation protein
H7K60_RS09060	COG3279	Response regulator of the LytR AlgR family
H7K60_RS09065	COG3275	phosphorelay sensor kinase activity
H7K60_RS09070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7K60_RS09070	COG2199	diguanylate cyclase activity
H7K60_RS09075	COG1454	alcohol dehydrogenase
H7K60_RS09075	COG1012	belongs to the aldehyde dehydrogenase family
H7K60_RS09085	COG2095	MarC family integral membrane protein
H7K60_RS09095	COG0601	transmembrane transport
H7K60_RS09100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K60_RS09115	COG0861	Integral membrane protein TerC family
H7K60_RS09120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7K60_RS09130	COG1301	dicarboxylic acid transport
H7K60_RS09145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7K60_RS09160	COG0537	adenosine 5'-monophosphoramidase activity
H7K60_RS09195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7K60_RS09200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7K60_RS09210	COG2354	Protein conserved in bacteria
H7K60_RS09225	COG2233	PERMEase
H7K60_RS09230	COG3150	esterase
H7K60_RS09235	COG1252	NADH dehydrogenase
H7K60_RS09255	COG0393	Putative heavy-metal-binding
H7K60_RS09265	COG1648	precorrin-2 dehydrogenase activity
H7K60_RS09265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7K60_RS09285	COG4667	esterase of the alpha-beta hydrolase superfamily
H7K60_RS09290	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7K60_RS09295	COG1368	sulfuric ester hydrolase activity
H7K60_RS09310	COG0527	aspartate kinase activity
H7K60_RS09315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7K60_RS09315	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7K60_RS09320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K60_RS09340	COG0596	Alpha beta hydrolase
H7K60_RS09345	COG0346	lactoylglutathione lyase activity
H7K60_RS09355	COG0583	DNA-binding transcription factor activity
H7K60_RS09360	COG1620	l-lactate permease
H7K60_RS09365	COG0247	lactate metabolic process
H7K60_RS09370	COG1139	Iron-sulfur cluster binding protein
H7K60_RS09400	COG0577	efflux transmembrane transporter activity
H7K60_RS09405	COG1136	(ABC) transporter
H7K60_RS09415	COG2814	Major facilitator Superfamily
H7K60_RS09435	COG0672	)-iron permease
H7K60_RS09465	COG0659	secondary active sulfate transmembrane transporter activity
H7K60_RS09535	COG4584	PFAM Integrase catalytic
H7K60_RS09540	COG1484	DNA-dependent DNA replication
H7K60_RS09550	COG1309	transcriptional regulator
H7K60_RS09565	COG1136	(ABC) transporter
H7K60_RS09580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7K60_RS09600	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7K60_RS09605	COG4584	PFAM Integrase catalytic
H7K60_RS09610	COG1484	DNA-dependent DNA replication
H7K60_RS09630	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7K60_RS09640	COG3385	transposase activity
H7K60_RS09650	COG2194	sulfuric ester hydrolase activity
H7K60_RS09660	COG3039	Transposase
H7K60_RS09680	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7K60_RS09715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7K60_RS09720	COG0840	transmembrane signaling receptor activity
H7K60_RS09730	COG2201	protein-glutamate methylesterase activity
H7K60_RS09740	COG0835	chemotaxis
H7K60_RS09745	COG0840	transmembrane signaling receptor activity
H7K60_RS09745	COG3290	protein histidine kinase activity
H7K60_RS09750	COG2198	Histidine kinase
H7K60_RS09750	COG0643	Histidine kinase
H7K60_RS09765	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H7K60_RS09770	COG0437	4 iron, 4 sulfur cluster binding
H7K60_RS09775	COG5557	Pfam Polysulphide reductase, NrfD
H7K60_RS09780	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H7K60_RS09785	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7K60_RS09790	COG1773	rubredoxin
H7K60_RS09795	COG0747	negative chemotaxis
H7K60_RS09805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7K60_RS09815	COG3842	ATPase activity
H7K60_RS09820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H7K60_RS09825	COG0375	protein maturation
H7K60_RS09830	COG0309	Hydrogenase expression formation protein (HypE)
H7K60_RS09840	COG0298	carbon dioxide binding
H7K60_RS09845	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7K60_RS09855	COG1921	L-seryl-tRNASec selenium transferase activity
H7K60_RS09865	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7K60_RS09875	COG3260	NADH ubiquinone oxidoreductase 20
H7K60_RS09880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K60_RS09885	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H7K60_RS09885	COG3261	NADH dehydrogenase
H7K60_RS09890	COG0650	Formate hydrogenlyase subunit 4
H7K60_RS09895	COG0651	ATP synthesis coupled electron transport
H7K60_RS09900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K60_RS09905	COG3158	transport of potassium into the cell
H7K60_RS09915	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K60_RS09940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7K60_RS09945	COG0326	Molecular chaperone. Has ATPase activity
H7K60_RS09950	COG0563	adenylate kinase activity
H7K60_RS09955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7K60_RS09965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K60_RS09980	COG5001	Diguanylate cyclase
H7K60_RS09980	COG3300	MHYT domain
H7K60_RS09985	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7K60_RS10005	COG1021	2,3-dihydroxybenzoate-AMP ligase
H7K60_RS10010	COG1535	isochorismatase
H7K60_RS10010	COG3433	isochorismatase activity
H7K60_RS10015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7K60_RS10020	COG1028	Short-chain dehydrogenase reductase Sdr
H7K60_RS10030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7K60_RS10035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7K60_RS10045	COG1120	ATPase activity
H7K60_RS10050	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7K60_RS10055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7K60_RS10060	COG4771	TonB-dependent receptor
H7K60_RS10100	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7K60_RS10105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7K60_RS10110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7K60_RS10125	COG1570	exodeoxyribonuclease VII activity
H7K60_RS10130	COG0697	spore germination
H7K60_RS10155	COG0516	GMP reductase activity
H7K60_RS10155	COG0517	IMP dehydrogenase activity
H7K60_RS10160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7K60_RS10160	COG0519	Catalyzes the synthesis of GMP from XMP
H7K60_RS10205	COG2062	phosphohistidine phosphatase, SixA
H7K60_RS10215	COG0697	spore germination
H7K60_RS10220	COG4166	transmembrane transport
H7K60_RS10225	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7K60_RS10230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7K60_RS10240	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7K60_RS10245	COG1136	(ABC) transporter
H7K60_RS10250	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7K60_RS10255	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H7K60_RS10265	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7K60_RS10270	COG0740	serine-type endopeptidase activity
H7K60_RS10275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7K60_RS10280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7K60_RS10285	COG0776	regulation of translation
H7K60_RS10290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K60_RS10295	COG0488	(ABC) transporter
H7K60_RS10300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7K60_RS10305	COG3162	membrane
H7K60_RS10320	COG1024	Enoyl-CoA hydratase
H7K60_RS10325	COG1115	amino acid carrier protein
H7K60_RS10335	COG3228	Belongs to the MtfA family
H7K60_RS10340	COG1584	GPR1 FUN34 yaaH family protein
H7K60_RS10375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7K60_RS10380	COG1960	acyl-CoA dehydrogenase activity
H7K60_RS10390	COG1960	acyl-CoA dehydrogenase activity
H7K60_RS10395	COG1024	Enoyl-CoA hydratase
H7K60_RS10400	COG1024	Enoyl-CoA hydratase
H7K60_RS10410	COG1028	Short-chain dehydrogenase reductase Sdr
H7K60_RS10420	COG0730	response to heat
H7K60_RS10440	COG5001	Diguanylate cyclase
H7K60_RS10440	COG3300	MHYT domain
H7K60_RS10445	COG0583	DNA-binding transcription factor activity
H7K60_RS10450	COG2723	6-phospho-beta-galactosidase activity
H7K60_RS10455	COG5001	Diguanylate cyclase
H7K60_RS10455	COG3300	MHYT domain
H7K60_RS10465	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7K60_RS10475	COG0583	DNA-binding transcription factor activity
H7K60_RS10480	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H7K60_RS10485	COG0673	inositol 2-dehydrogenase activity
H7K60_RS10490	COG0583	DNA-binding transcription factor activity
H7K60_RS10500	COG1560	Kdo2-lipid A biosynthetic process
H7K60_RS10505	COG1560	Kdo2-lipid A biosynthetic process
H7K60_RS10530	COG0417	DNA replication proofreading
H7K60_RS10560	COG0534	Mate efflux family protein
H7K60_RS10570	COG0307	riboflavin synthase, alpha
H7K60_RS10580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K60_RS10585	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H7K60_RS10590	COG0697	spore germination
H7K60_RS10595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7K60_RS10635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7K60_RS10640	COG3099	Belongs to the UPF0263 family
H7K60_RS10645	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7K60_RS10650	COG2894	cell division
H7K60_RS10655	COG0850	regulation of cytokinetic process
H7K60_RS10660	COG3100	YcgL domain-containing protein
H7K60_RS10665	COG2951	lytic endotransglycosylase activity
H7K60_RS10670	COG1760	l-serine dehydratase
H7K60_RS10675	COG1760	l-serine dehydratase
H7K60_RS10680	COG3123	guanosine phosphorylase activity
H7K60_RS10705	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7K60_RS10710	COG2067	long-chain fatty acid transport protein
H7K60_RS10725	COG1595	DNA-templated transcription, initiation
H7K60_RS10755	COG0714	Associated with various cellular activities
H7K60_RS10760	COG0183	Belongs to the thiolase family
H7K60_RS10765	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K60_RS10765	COG1024	Enoyl-CoA hydratase
H7K60_RS10785	COG3829	transcription factor binding
H7K60_RS10790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7K60_RS10795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7K60_RS10800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7K60_RS10810	COG0549	Belongs to the carbamate kinase family
H7K60_RS10815	COG0697	spore germination
H7K60_RS10820	COG3608	succinylglutamate desuccinylase aspartoacylase
H7K60_RS10820	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7K60_RS10825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7K60_RS10830	COG2068	MobA-Related Protein
H7K60_RS10835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K60_RS10835	COG0493	'glutamate synthase
H7K60_RS10840	COG0402	S-adenosylhomocysteine deaminase activity
H7K60_RS10845	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7K60_RS10850	COG2080	2 iron, 2 sulfur cluster binding
H7K60_RS10850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K60_RS10855	COG2233	PERMEase
H7K60_RS10860	COG0402	S-adenosylhomocysteine deaminase activity
H7K60_RS10865	COG2252	PERMEase
H7K60_RS10870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7K60_RS10875	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7K60_RS10880	COG2080	2 iron, 2 sulfur cluster binding
H7K60_RS10890	COG3134	Outer membrane lipoprotein
H7K60_RS10900	COG1288	antiporter activity
H7K60_RS10905	COG0318	PFAM AMP-dependent synthetase and ligase
H7K60_RS10910	COG0140	phosphoribosyl-ATP diphosphatase activity
H7K60_RS10910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7K60_RS10915	COG0107	imidazoleglycerol-phosphate synthase activity
H7K60_RS10920	COG0784	Response regulator, receiver
H7K60_RS10920	COG2198	Histidine kinase
H7K60_RS10920	COG2205	protein histidine kinase activity
H7K60_RS10925	COG2199	diguanylate cyclase activity
H7K60_RS10930	COG3437	response regulator, receiver
H7K60_RS10935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7K60_RS10940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7K60_RS10945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7K60_RS10945	COG0131	Imidazoleglycerol-phosphate dehydratase
H7K60_RS10950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7K60_RS10955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7K60_RS10960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7K60_RS10970	COG1199	ATP-dependent helicase activity
H7K60_RS10975	COG1214	PFAM Peptidase M22, glycoprotease
H7K60_RS10985	COG2226	methyltransferase
H7K60_RS10985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7K60_RS10985	COG0596	Alpha beta hydrolase
H7K60_RS10990	COG0318	PFAM AMP-dependent synthetase and ligase
H7K60_RS10995	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H7K60_RS11010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7K60_RS11015	COG2832	Protein of unknown function (DUF454)
H7K60_RS11020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7K60_RS11030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7K60_RS11050	COG0517	IMP dehydrogenase activity
H7K60_RS11050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7K60_RS11050	COG0617	tRNA 3'-terminal CCA addition
H7K60_RS11055	COG1643	Atp-dependent helicase
H7K60_RS11065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7K60_RS11075	COG3437	response regulator, receiver
H7K60_RS11080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K60_RS11085	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H7K60_RS11090	COG0709	Synthesizes selenophosphate from selenide and ATP
H7K60_RS11105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7K60_RS11115	COG1254	Belongs to the acylphosphatase family
H7K60_RS11120	COG0625	glutathione transferase activity
H7K60_RS11125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K60_RS11125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K60_RS11130	COG0489	protein tyrosine kinase activity
H7K60_RS11135	COG0572	uridine kinase
H7K60_RS11140	COG0717	Belongs to the dCTP deaminase family
H7K60_RS11145	COG0306	phosphate transporter
H7K60_RS11150	COG1530	ribonuclease E activity
H7K60_RS11155	COG0564	pseudouridine synthase activity
H7K60_RS11160	COG0546	phosphoglycolate phosphatase activity
H7K60_RS11165	COG0424	maF-like protein
H7K60_RS11170	COG2814	Major facilitator Superfamily
H7K60_RS11185	COG1399	metal-binding, possibly nucleic acid-binding protein
H7K60_RS11190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7K60_RS11195	COG0416	fatty acid biosynthetic process
H7K60_RS11200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7K60_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
H7K60_RS11215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7K60_RS11225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7K60_RS11230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7K60_RS11235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7K60_RS11240	COG0470	DNA polymerase III
H7K60_RS11245	COG0084	hydrolase, TatD family'
H7K60_RS11260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7K60_RS11260	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H7K60_RS11265	COG3008	intermembrane lipid transfer
H7K60_RS11270	COG2995	paraquat-inducible protein a
H7K60_RS11280	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7K60_RS11285	COG0372	Belongs to the citrate synthase family
H7K60_RS11330	COG4221	oxidoreductase activity
H7K60_RS11340	COG3141	response to X-ray
H7K60_RS11400	COG1067	ATP-dependent peptidase activity
H7K60_RS11405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K60_RS11420	COG0488	(ABC) transporter
H7K60_RS11430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7K60_RS11430	COG0116	Belongs to the methyltransferase superfamily
H7K60_RS11440	COG0167	dihydroorotate dehydrogenase activity
H7K60_RS11445	COG2902	Dehydrogenase
H7K60_RS11455	COG0308	aminopeptidase N
H7K60_RS11465	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H7K60_RS11470	COG1956	GAF domain-containing protein
H7K60_RS11480	COG3278	Belongs to the heme-copper respiratory oxidase family
H7K60_RS11495	COG2010	Cytochrome c
H7K60_RS11520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K60_RS11525	COG0589	response to stress
H7K60_RS11530	COG0037	tRNA processing
H7K60_RS11545	COG0625	glutathione transferase activity
H7K60_RS11550	COG1869	D-ribose catabolic process
H7K60_RS11555	COG1129	ABC transporter
H7K60_RS11560	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K60_RS11565	COG1879	ABC-type sugar transport system periplasmic component
H7K60_RS11570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K60_RS11575	COG1609	Transcriptional regulator
H7K60_RS11580	COG3300	MHYT domain
H7K60_RS11580	COG5001	Diguanylate cyclase
H7K60_RS11610	COG0776	regulation of translation
H7K60_RS11615	COG0072	phenylalanine-tRNA ligase activity
H7K60_RS11615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K60_RS11620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7K60_RS11625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7K60_RS11630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7K60_RS11635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7K60_RS11640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7K60_RS11665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K60_RS11675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7K60_RS11680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7K60_RS11685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K60_RS11690	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H7K60_RS11695	COG3313	Fe-S protein
H7K60_RS11700	COG2942	2-epimerase
H7K60_RS11705	COG3716	PTS system mannose fructose sorbose family IID component
H7K60_RS11710	COG3715	PTS system
H7K60_RS11715	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7K60_RS11715	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K60_RS11730	COG1609	Transcriptional regulator
H7K60_RS11735	COG2140	Oxalate decarboxylase
H7K60_RS11740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7K60_RS11740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7K60_RS11740	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H7K60_RS11745	COG1105	Belongs to the carbohydrate kinase PfkB family
H7K60_RS11750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K60_RS11750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K60_RS11755	COG1609	Transcriptional regulator
H7K60_RS11760	COG0814	amino acid
H7K60_RS11770	COG5654	RES domain protein
H7K60_RS11775	COG0513	Belongs to the DEAD box helicase family
H7K60_RS11785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7K60_RS11790	COG2890	protein-(glutamine-N5) methyltransferase activity
H7K60_RS11795	COG2840	Smr protein MutS2
H7K60_RS11805	COG3706	GGDEF domain
H7K60_RS11810	COG0406	alpha-ribazole phosphatase activity
H7K60_RS11835	COG2824	Alkylphosphonate utilization operon protein PhnA
H7K60_RS11845	COG0384	phenazine biosynthesis protein PhzF
H7K60_RS11875	COG0242	peptide deformylase activity
H7K60_RS11895	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7K60_RS11900	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H7K60_RS11910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7K60_RS11915	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H7K60_RS11925	COG0205	6-phosphofructokinase activity
H7K60_RS11930	COG1473	amidohydrolase
H7K60_RS11935	COG1011	Hydrolase
H7K60_RS11940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7K60_RS11990	COG3593	DNA synthesis involved in DNA repair
H7K60_RS12005	COG0583	DNA-binding transcription factor activity
H7K60_RS12010	COG0730	response to heat
H7K60_RS12015	COG3148	PFAM DTW domain containing protein
H7K60_RS12025	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7K60_RS12035	COG0386	Belongs to the glutathione peroxidase family
H7K60_RS12040	COG0513	Belongs to the DEAD box helicase family
H7K60_RS12045	COG0456	acetyltransferase
H7K60_RS12055	COG1742	UPF0060 membrane protein
H7K60_RS12085	COG2329	Antibiotic biosynthesis monooxygenase
H7K60_RS12090	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7K60_RS12110	COG3243	poly(R)-hydroxyalkanoic acid synthase
H7K60_RS12120	COG2501	S4 domain
H7K60_RS12135	COG1132	(ABC) transporter
H7K60_RS12140	COG1132	(ABC) transporter
H7K60_RS12150	COG3118	belongs to the thioredoxin family
H7K60_RS12155	COG0471	metal ion transport
H7K60_RS12160	COG0058	SHG alpha-glucan phosphorylase activity
H7K60_RS12190	COG0814	amino acid
H7K60_RS12195	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H7K60_RS12200	COG0514	ATP-dependent DNA helicase (RecQ)
H7K60_RS12205	COG2766	serine protein kinase
H7K60_RS12215	COG2719	SpoVR family
H7K60_RS12220	COG2186	Transcriptional regulator
H7K60_RS12225	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7K60_RS12230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7K60_RS12235	COG0586	Pfam SNARE associated Golgi protein
H7K60_RS12245	COG0556	nucleotide-excision repair
H7K60_RS12255	COG2985	domain, Protein
H7K60_RS12255	COG0569	domain protein
H7K60_RS12280	COG4565	transcriptional regulatory protein
H7K60_RS12285	COG3290	protein histidine kinase activity
H7K60_RS12290	COG1846	Transcriptional regulator
H7K60_RS12290	COG1940	carbohydrate kinase activity
H7K60_RS12295	COG0840	transmembrane signaling receptor activity
H7K60_RS12300	COG3012	SEC-C Motif Domain Protein
H7K60_RS12305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7K60_RS12310	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
H7K60_RS12315	COG0247	lactate metabolic process
H7K60_RS12335	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H7K60_RS12340	COG0437	4 iron, 4 sulfur cluster binding
H7K60_RS12345	COG3301	Polysulphide reductase, NrfD
H7K60_RS12350	COG1138	Cytochrome C-type biogenesis protein
H7K60_RS12355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7K60_RS12360	COG4235	cytochrome complex assembly
H7K60_RS12360	COG3088	subunit of a heme lyase
H7K60_RS12365	COG1051	belongs to the nudix hydrolase family
H7K60_RS12385	COG3046	protein related to deoxyribodipyrimidine photolyase
H7K60_RS12390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K60_RS12415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7K60_RS12430	COG4774	siderophore transport
H7K60_RS12435	COG4977	sequence-specific DNA binding
H7K60_RS12445	COG0583	DNA-binding transcription factor activity
H7K60_RS12450	COG2910	NAD(P)H-binding
H7K60_RS12465	COG0612	Peptidase, M16
H7K60_RS12470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7K60_RS12480	COG1944	ATP diphosphatase activity
H7K60_RS12485	COG2116	formate transmembrane transporter activity
H7K60_RS12490	COG1882	Formate acetyltransferase
H7K60_RS12495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7K60_RS12500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H7K60_RS12505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7K60_RS12515	COG1840	ABC-type Fe3 transport system, periplasmic component
H7K60_RS12520	COG3842	ATPase activity
H7K60_RS12530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K60_RS12535	COG2983	Belongs to the UPF0260 family
H7K60_RS12545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H7K60_RS12550	COG0045	succinate-CoA ligase (ADP-forming) activity
H7K60_RS12555	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7K60_RS12560	COG0567	Dehydrogenase, E1 component
H7K60_RS12570	COG1053	succinate dehydrogenase
H7K60_RS12575	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7K60_RS12600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7K60_RS12605	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7K60_RS12605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K60_RS12615	COG3069	C4-dicarboxylate transmembrane transporter activity
H7K60_RS12630	COG1451	nucleotide metabolic process
H7K60_RS12645	COG0254	rRNA binding
H7K60_RS12650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7K60_RS12660	COG0583	DNA-binding transcription factor activity
H7K60_RS12670	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7K60_RS12680	COG1879	ABC-type sugar transport system periplasmic component
H7K60_RS12685	COG1069	ribulokinase activity
H7K60_RS12695	COG2160	L-arabinose isomerase activity
H7K60_RS12700	COG2925	Exonuclease
H7K60_RS12710	COG3345	alpha-galactosidase
H7K60_RS12715	COG1380	Effector of murein hydrolase LrgA
H7K60_RS12720	COG1346	cytolysis
H7K60_RS12725	COG0295	cytidine deaminase activity
H7K60_RS12730	COG1022	Amp-dependent synthetase and ligase
H7K60_RS12745	COG0861	Integral membrane protein TerC family
H7K60_RS12750	COG2885	chlorophyll binding
H7K60_RS12755	COG2199	diguanylate cyclase activity
H7K60_RS12780	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7K60_RS12790	COG3768	UPF0283 membrane protein
H7K60_RS12795	COG3106	COG3106 Predicted ATPase
H7K60_RS12810	COG1842	Phage shock protein A
H7K60_RS12815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7K60_RS12825	COG4168	peptide transport system, permease
H7K60_RS12830	COG4171	peptide transport system, permease
H7K60_RS12840	COG4172	Belongs to the ABC transporter superfamily
H7K60_RS12850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7K60_RS12855	COG1286	toxin biosynthetic process
H7K60_RS12860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7K60_RS12865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7K60_RS12870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7K60_RS12875	COG1674	ftsk spoiiie
H7K60_RS12875	COG0531	amino acid
H7K60_RS12885	COG0686	Belongs to the AlaDH PNT family
H7K60_RS12890	COG0492	ferredoxin-NADP+ reductase activity
H7K60_RS12895	COG3706	GGDEF domain
H7K60_RS12900	COG3134	Outer membrane lipoprotein
H7K60_RS12905	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7K60_RS12910	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7K60_RS12915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7K60_RS12920	COG0542	response to heat
H7K60_RS12925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7K60_RS12930	COG1278	Cold shock
H7K60_RS12935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7K60_RS12975	COG2226	methyltransferase
H7K60_RS12985	COG0210	DNA helicase
H7K60_RS12990	COG1205	dead DEAH box helicase
H7K60_RS12990	COG1111	helicase
H7K60_RS13000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7K60_RS13015	COG3039	Transposase
H7K60_RS13100	COG4584	PFAM Integrase catalytic
H7K60_RS13105	COG1484	DNA-dependent DNA replication
H7K60_RS13120	COG3550	peptidyl-serine autophosphorylation
H7K60_RS13180	COG3829	transcription factor binding
H7K60_RS13255	COG3501	Rhs element vgr protein
H7K60_RS13285	COG1435	thymidine kinase activity
H7K60_RS13290	COG1757	Na H antiporter
H7K60_RS13295	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7K60_RS13300	COG2096	Adenosyltransferase
H7K60_RS13305	COG3530	Putative quorum-sensing-regulated virulence factor
H7K60_RS13310	COG0602	queuosine metabolic process
H7K60_RS13315	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7K60_RS13335	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7K60_RS13345	COG0776	regulation of translation
H7K60_RS13350	COG0539	negative regulation of cytoplasmic translation
H7K60_RS13355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7K60_RS13360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7K60_RS13370	COG0583	DNA-binding transcription factor activity
H7K60_RS13390	COG0778	Nitroreductase
H7K60_RS13395	COG5001	Diguanylate cyclase
H7K60_RS13395	COG3300	MHYT domain
H7K60_RS13405	COG0583	DNA-binding transcription factor activity
H7K60_RS13410	COG3437	response regulator, receiver
H7K60_RS13435	COG4989	oxidoreductase activity
H7K60_RS13440	COG0724	RNA recognition motif
H7K60_RS13460	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H7K60_RS13475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7K60_RS13480	COG1360	Flagellar Motor Protein
H7K60_RS13485	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K60_RS13490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K60_RS13495	COG0649	NAD binding
H7K60_RS13495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K60_RS13510	COG1034	ATP synthesis coupled electron transport
H7K60_RS13515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7K60_RS13520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K60_RS13525	COG0839	Belongs to the complex I subunit 6 family
H7K60_RS13530	COG0713	ATP synthesis coupled electron transport
H7K60_RS13540	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7K60_RS13545	COG1007	ATP synthesis coupled electron transport
H7K60_RS13550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7K60_RS13550	COG0047	phosphoribosylformylglycinamidine synthase activity
H7K60_RS13555	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7K60_RS13560	COG1645	bacterial-type flagellum-dependent swarming motility
H7K60_RS13565	COG1160	GTP binding
H7K60_RS13570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K60_RS13575	COG2976	Protein conserved in bacteria
H7K60_RS13580	COG0124	histidyl-tRNA synthetase
H7K60_RS13585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7K60_RS13600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7K60_RS13605	COG0105	UTP biosynthetic process
H7K60_RS13610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7K60_RS13620	COG0633	Ferredoxin
H7K60_RS13625	COG0443	Heat shock 70 kDa protein
H7K60_RS13630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7K60_RS13640	COG0822	iron-sulfur transferase activity
H7K60_RS13645	COG1104	cysteine desulfurase activity
H7K60_RS13665	COG3154	lipid carrier protein
H7K60_RS13670	COG0826	peptidase U32
H7K60_RS13675	COG0826	peptidase U32
H7K60_RS13690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7K60_RS13695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7K60_RS13700	COG1862	Preprotein translocase
H7K60_RS13705	COG0343	queuine tRNA-ribosyltransferase activity
H7K60_RS13710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7K60_RS13715	COG0517	IMP dehydrogenase activity
H7K60_RS13725	COG3634	alkyl hydroperoxide reductase activity
H7K60_RS13745	COG1393	Belongs to the ArsC family
H7K60_RS13750	COG0798	PFAM Bile acid sodium symporter
H7K60_RS13780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7K60_RS13780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7K60_RS13785	COG0509	glycine decarboxylation via glycine cleavage system
H7K60_RS13790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7K60_RS13795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K60_RS13800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7K60_RS13820	COG2814	Major facilitator Superfamily
H7K60_RS13825	COG0625	glutathione transferase activity
H7K60_RS13835	COG0483	inositol monophosphate 1-phosphatase activity
H7K60_RS13855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7K60_RS13875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7K60_RS13885	COG2089	acid synthase
H7K60_RS13890	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H7K60_RS13910	COG1083	cytidylyl-transferase
H7K60_RS13940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7K60_RS13960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7K60_RS13960	COG0301	tRNA thio-modification
H7K60_RS13970	COG4953	penicillin-binding protein 1C
H7K60_RS13975	COG2373	Large extracellular alpha-helical protein
H7K60_RS13980	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7K60_RS13990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7K60_RS14010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K60_RS14020	COG2431	L-lysine efflux transmembrane transporter activity
H7K60_RS14025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7K60_RS14030	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H7K60_RS14045	COG1393	Belongs to the ArsC family
H7K60_RS14055	COG4783	chaperone-mediated protein folding
H7K60_RS14060	COG0425	Belongs to the sulfur carrier protein TusA family
H7K60_RS14085	COG3842	ATPase activity
H7K60_RS14090	COG3833	ABC-type maltose transport systems, permease component
H7K60_RS14095	COG1175	transmembrane transport
H7K60_RS14105	COG3081	Nucleoid-associated protein
H7K60_RS14110	COG3082	Protein of unknown function (DUF1414)
H7K60_RS14115	COG3083	sulfuric ester hydrolase activity
H7K60_RS14120	COG4771	TonB-dependent receptor
H7K60_RS14125	COG1770	oligopeptidase
H7K60_RS14145	COG4574	serine-type endopeptidase inhibitor activity
H7K60_RS14150	COG3085	chromosome segregation
H7K60_RS14155	COG0583	DNA-binding transcription factor activity
H7K60_RS14160	COG0287	Prephenate dehydrogenase
H7K60_RS14160	COG1605	Chorismate mutase
H7K60_RS14165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7K60_RS14170	COG0584	glycerophosphoryl diester phosphodiesterase
H7K60_RS14185	COG1349	DNA-binding transcription factor activity
H7K60_RS14190	COG2271	Major facilitator Superfamily
H7K60_RS14195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7K60_RS14200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7K60_RS14205	COG0583	DNA-binding transcription factor activity
H7K60_RS14230	COG0656	L-ascorbic acid biosynthetic process
H7K60_RS14235	COG2814	Major facilitator Superfamily
H7K60_RS14245	COG1294	oxidase, subunit
H7K60_RS14250	COG1271	oxidase subunit
H7K60_RS14255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7K60_RS14265	COG2979	Protein of unknown function (DUF533)
H7K60_RS14290	COG2271	Major facilitator Superfamily
H7K60_RS14295	COG0583	DNA-binding transcription factor activity
H7K60_RS14305	COG2807	transmembrane transport
H7K60_RS14315	COG1187	pseudouridine synthase activity
H7K60_RS14330	COG0346	lactoylglutathione lyase activity
H7K60_RS14340	COG1403	HNH endonuclease
H7K60_RS14350	COG2964	Protein conserved in bacteria
H7K60_RS14355	COG3681	Belongs to the UPF0597 family
H7K60_RS14365	COG0814	amino acid
H7K60_RS14385	COG1166	arginine decarboxylase activity
H7K60_RS14395	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7K60_RS14425	COG0583	DNA-binding transcription factor activity
H7K60_RS14435	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H7K60_RS14440	COG0840	transmembrane signaling receptor activity
H7K60_RS14445	COG0302	gtp cyclohydrolase
H7K60_RS14455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7K60_RS14460	COG2267	carboxylic ester hydrolase activity
H7K60_RS14465	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7K60_RS14480	COG0314	molybdopterin synthase activity
H7K60_RS14485	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7K60_RS14490	COG0315	cyclic pyranopterin monophosphate synthase activity
H7K60_RS14495	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7K60_RS14500	COG3005	denitrification pathway
H7K60_RS14510	COG0348	domain, Protein
H7K60_RS14515	COG0437	4 iron, 4 sulfur cluster binding
H7K60_RS14520	COG0243	molybdopterin cofactor binding
H7K60_RS14530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K60_RS14530	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K60_RS14535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7K60_RS14540	COG3850	Histidine kinase
H7K60_RS14545	COG2197	response regulator
H7K60_RS14575	COG0121	glutamine amidotransferase
H7K60_RS14580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7K60_RS14585	COG1960	acyl-CoA dehydrogenase activity
H7K60_RS14590	COG3437	response regulator, receiver
H7K60_RS14590	COG0784	Response regulator, receiver
H7K60_RS14605	COG0328	RNA-DNA hybrid ribonuclease activity
H7K60_RS14610	COG2226	methyltransferase
H7K60_RS14615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7K60_RS14620	COG1388	LysM domain
H7K60_RS14620	COG0741	lytic transglycosylase activity
H7K60_RS14625	COG3021	interspecies interaction between organisms
H7K60_RS14635	COG1607	acyl-coa hydrolase
H7K60_RS14650	COG0741	lytic transglycosylase activity
H7K60_RS14660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7K60_RS14680	COG2911	Protein conserved in bacteria
H7K60_RS14685	COG0729	surface antigen
H7K60_RS14695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7K60_RS14700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7K60_RS14710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7K60_RS14720	COG4134	Bacterial extracellular solute-binding protein
H7K60_RS14730	COG4136	ATPase activity
H7K60_RS14735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7K60_RS14740	COG2951	lytic endotransglycosylase activity
H7K60_RS14755	COG1846	Transcriptional regulator
H7K60_RS14765	COG0033	Phosphoglucomutase
H7K60_RS14770	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H7K60_RS14775	COG0596	Alpha beta hydrolase
H7K60_RS14790	COG0716	FMN binding
H7K60_RS14800	COG0735	belongs to the Fur family
H7K60_RS14805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7K60_RS14820	COG1263	PTS System
H7K60_RS14820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7K60_RS14820	COG2190	(PTS) system
H7K60_RS14825	COG0363	glucosamine-6-phosphate deaminase activity
H7K60_RS14830	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7K60_RS14835	COG1846	Transcriptional regulator
H7K60_RS14835	COG1940	carbohydrate kinase activity
H7K60_RS14840	COG2194	sulfuric ester hydrolase activity
H7K60_RS14845	COG0217	transcriptional regulatory protein
H7K60_RS14850	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7K60_RS14855	COG1801	Protein of unknown function DUF72
H7K60_RS14860	COG4106	trans-aconitate 2-methyltransferase activity
H7K60_RS14865	COG0500	methyltransferase
H7K60_RS14885	COG0450	alkyl hydroperoxide reductase
H7K60_RS14890	COG0583	DNA-binding transcription factor activity
H7K60_RS14905	COG0791	NLP P60 protein
H7K60_RS14920	COG1309	transcriptional regulator
H7K60_RS14960	COG0534	Mate efflux family protein
H7K60_RS14980	COG3385	transposase activity
H7K60_RS14985	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7K60_RS14985	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7K60_RS14985	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7K60_RS14985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7K60_RS14995	COG0633	Ferredoxin
H7K60_RS14995	COG3217	Mosc domain protein beta barrel domain protein
H7K60_RS14995	COG0633	Ferredoxin
H7K60_RS14995	COG3217	Mosc domain protein beta barrel domain protein
H7K60_RS15005	COG0501	Belongs to the peptidase M48B family
H7K60_RS15010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7K60_RS15015	COG1073	alpha beta
H7K60_RS15015	COG2226	methyltransferase
H7K60_RS15020	COG0156	8-amino-7-oxononanoate synthase activity
H7K60_RS15025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7K60_RS15045	COG0017	Asparaginyl-tRNA synthetase
H7K60_RS15050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7K60_RS15065	COG3069	C4-dicarboxylate transmembrane transporter activity
H7K60_RS15075	COG0583	DNA-binding transcription factor activity
H7K60_RS15080	COG1393	Belongs to the ArsC family
H7K60_RS15085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7K60_RS15090	COG1876	peptidase activity
H7K60_RS15100	COG3263	regulation of cellular component size
H7K60_RS15120	COG1280	lysine exporter protein (LysE YggA)
H7K60_RS15150	COG0564	pseudouridine synthase activity
H7K60_RS15160	COG1454	alcohol dehydrogenase
H7K60_RS15165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7K60_RS15170	COG0702	epimerase
H7K60_RS15175	COG2914	Belongs to the UPF0125 (RnfH) family
H7K60_RS15180	COG2867	negative regulation of translational initiation
H7K60_RS15185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7K60_RS15195	COG0582	viral genome integration into host DNA
H7K60_RS15205	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7K60_RS15255	COG0514	ATP-dependent DNA helicase (RecQ)
H7K60_RS15260	COG1940	carbohydrate kinase activity
H7K60_RS15265	COG0583	DNA-binding transcription factor activity
H7K60_RS15270	COG3048	D-serine ammonia-lyase activity
H7K60_RS15280	COG0538	isocitrate dehydrogenase activity
H7K60_RS15285	COG2207	Transcriptional regulator
H7K60_RS15290	COG1482	cell wall glycoprotein biosynthetic process
H7K60_RS15305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7K60_RS15315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7K60_RS15320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7K60_RS15320	COG1263	PTS System
H7K60_RS15325	COG1609	Transcriptional regulator
H7K60_RS15335	COG0789	Transcriptional regulator
H7K60_RS15365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7K60_RS15365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7K60_RS15365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K60_RS15375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7K60_RS15385	COG1187	pseudouridine synthase activity
H7K60_RS15395	COG0482	sulfurtransferase activity
H7K60_RS15400	COG2915	High frequency lysogenization protein hflD homolog
H7K60_RS15405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7K60_RS15410	COG2850	peptidyl-arginine hydroxylation
H7K60_RS15420	COG3153	acetyltransferase
H7K60_RS15430	COG0625	glutathione transferase activity
H7K60_RS15435	COG0259	pyridoxamine-phosphate oxidase activity
H7K60_RS15450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7K60_RS15450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7K60_RS15455	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7K60_RS15470	COG4235	cytochrome complex assembly
H7K60_RS15470	COG3088	subunit of a heme lyase
H7K60_RS15475	COG4235	cytochrome complex assembly
H7K60_RS15475	COG3088	subunit of a heme lyase
H7K60_RS15480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7K60_RS15485	COG1138	Cytochrome C-type biogenesis protein
H7K60_RS15490	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7K60_RS15495	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7K60_RS15500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7K60_RS15505	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7K60_RS15520	COG0835	chemotaxis
H7K60_RS15530	COG1192	Involved in chromosome partitioning
H7K60_RS15535	COG1360	Flagellar Motor Protein
H7K60_RS15540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7K60_RS15545	COG2201	protein-glutamate methylesterase activity
H7K60_RS15550	COG0643	Histidine kinase
H7K60_RS15550	COG2198	Histidine kinase
H7K60_RS15550	COG0784	Response regulator, receiver
H7K60_RS15555	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H7K60_RS15580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7K60_RS15590	COG1684	flagellar biosynthetic protein fliR
H7K60_RS15645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7K60_RS15655	COG1677	Flagellar hook-basal body complex protein FliE
H7K60_RS15670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7K60_RS15680	COG1073	alpha beta
H7K60_RS15680	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H7K60_RS15680	COG3064	Membrane
H7K60_RS15685	COG2994	toxin metabolic process
H7K60_RS15695	COG2274	protein secretion by the type I secretion system
H7K60_RS15705	COG2274	protein secretion by the type I secretion system
H7K60_RS15725	COG1737	Transcriptional regulator
H7K60_RS15730	COG0469	pyruvate kinase activity
H7K60_RS15740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K60_RS15745	COG1960	acyl-CoA dehydrogenase activity
H7K60_RS15755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7K60_RS15765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7K60_RS15785	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7K60_RS15795	COG1401	restriction endodeoxyribonuclease activity
H7K60_RS15800	COG0732	type I restriction modification DNA specificity domain
H7K60_RS15805	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7K60_RS15865	COG2003	Belongs to the UPF0758 family
H7K60_RS15950	COG3311	Transcriptional regulator
H7K60_RS15990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7K60_RS15995	COG0583	DNA-binding transcription factor activity
H7K60_RS16030	COG1454	alcohol dehydrogenase
H7K60_RS16030	COG1012	belongs to the aldehyde dehydrogenase family
H7K60_RS16040	COG1454	alcohol dehydrogenase
H7K60_RS16040	COG1012	belongs to the aldehyde dehydrogenase family
H7K60_RS16045	COG1882	Formate acetyltransferase
H7K60_RS16050	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7K60_RS16060	COG4869	propanediol catabolic process
H7K60_RS16080	COG5002	protein histidine kinase activity
H7K60_RS16085	COG0745	RESPONSE REGULATOR receiver
H7K60_RS16090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K60_RS16095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K60_RS16105	COG1388	LysM domain
H7K60_RS16105	COG1376	ErfK ybiS ycfS ynhG family protein
H7K60_RS16120	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H7K60_RS16125	COG0791	NLP P60 protein
H7K60_RS16130	COG2091	lysine biosynthetic process via aminoadipic acid
H7K60_RS16135	COG3118	belongs to the thioredoxin family
H7K60_RS16145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7K60_RS16150	COG0788	formyltetrahydrofolate deformylase activity
H7K60_RS16160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7K60_RS16180	COG0366	Alpha amylase catalytic
H7K60_RS16185	COG1196	nuclear chromosome segregation
H7K60_RS16185	COG0741	lytic transglycosylase activity
H7K60_RS16185	COG0739	heme binding
H7K60_RS16190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7K60_RS16195	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7K60_RS16205	COG0673	inositol 2-dehydrogenase activity
H7K60_RS16225	COG3152	Membrane
H7K60_RS16245	COG1032	radical SAM domain protein
H7K60_RS16255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7K60_RS16260	COG1566	PFAM secretion protein HlyD family protein
H7K60_RS16270	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7K60_RS16275	COG0733	neurotransmitter:sodium symporter activity
H7K60_RS16305	COG0281	malic enzyme
H7K60_RS16315	COG0534	Mate efflux family protein
H7K60_RS16330	COG2233	PERMEase
H7K60_RS16335	COG0095	Lipoate-protein ligase
H7K60_RS16340	COG1115	amino acid carrier protein
H7K60_RS16345	COG0019	diaminopimelate decarboxylase activity
H7K60_RS16355	COG0678	peroxiredoxin activity
H7K60_RS16365	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H7K60_RS16385	COG1131	(ABC) transporter
H7K60_RS16390	COG0545	Peptidyl-prolyl cis-trans isomerase
H7K60_RS16400	COG3142	Participates in the control of copper homeostasis
H7K60_RS16425	COG5002	protein histidine kinase activity
H7K60_RS16430	COG0745	RESPONSE REGULATOR receiver
H7K60_RS16435	COG0346	lactoylglutathione lyase activity
H7K60_RS16440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H7K60_RS16445	COG1960	acyl-CoA dehydrogenase activity
H7K60_RS16450	COG3284	Transcriptional regulator
H7K60_RS16465	COG0697	spore germination
H7K60_RS16470	COG4565	transcriptional regulatory protein
H7K60_RS16475	COG3290	protein histidine kinase activity
H7K60_RS16480	COG0281	malic enzyme
H7K60_RS16495	COG1846	Transcriptional regulator
H7K60_RS16500	COG1566	PFAM secretion protein HlyD family protein
H7K60_RS16540	COG0602	queuosine metabolic process
H7K60_RS16545	COG1328	CTP reductase activity
H7K60_RS16555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7K60_RS16560	COG3115	cell septum assembly
H7K60_RS16565	COG1196	nuclear chromosome segregation
H7K60_RS16575	COG2860	membrane
H7K60_RS16585	COG3108	Peptidase M15
H7K60_RS16590	COG2989	Protein conserved in bacteria
H7K60_RS16605	COG0463	Glycosyl transferase, family 2
H7K60_RS16620	COG0366	Alpha amylase catalytic
H7K60_RS16655	COG3706	GGDEF domain
H7K60_RS16660	COG0037	tRNA processing
H7K60_RS16665	COG3590	peptidase
H7K60_RS16675	COG0488	(ABC) transporter
H7K60_RS16685	COG0531	amino acid
H7K60_RS16695	COG1073	alpha beta
H7K60_RS16700	COG1073	alpha beta
H7K60_RS16710	COG1234	tRNA 3'-trailer cleavage
H7K60_RS16715	COG0814	amino acid
H7K60_RS16730	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7K60_RS16735	COG1982	Orn Lys Arg decarboxylase major
H7K60_RS16740	COG0531	amino acid
H7K60_RS16745	COG3710	Transcriptional regulator
H7K60_RS16750	COG0825	malonyl-CoA metabolic process
H7K60_RS16760	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7K60_RS16765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7K60_RS16770	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7K60_RS16775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7K60_RS16780	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7K60_RS16795	COG0750	zinc metalloprotease
H7K60_RS16800	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7K60_RS16805	COG0575	Belongs to the CDS family
H7K60_RS16810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7K60_RS16815	COG0233	cytoplasmic translational termination
H7K60_RS16820	COG0528	UMP kinase activity
H7K60_RS16825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7K60_RS16830	COG0052	Belongs to the universal ribosomal protein uS2 family
H7K60_RS16835	COG0024	Methionine aminopeptidase
H7K60_RS16840	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H7K60_RS16845	COG2171	N-acyltransferase activity
H7K60_RS16855	COG1263	PTS System
H7K60_RS16855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7K60_RS16865	COG4580	involved in the transport of maltose and maltodextrins
H7K60_RS16875	COG0564	pseudouridine synthase activity
H7K60_RS16880	COG3098	single-species biofilm formation
H7K60_RS16905	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H7K60_RS16915	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7K60_RS16915	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7K60_RS16930	COG1611	Belongs to the LOG family
H7K60_RS16935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7K60_RS16940	COG0473	3-isopropylmalate dehydrogenase activity
H7K60_RS16950	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H7K60_RS16955	COG2363	Small membrane protein
H7K60_RS16965	COG0583	DNA-binding transcription factor activity
H7K60_RS16970	COG0840	transmembrane signaling receptor activity
H7K60_RS16975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7K60_RS16990	COG1477	protein flavinylation
H7K60_RS16995	COG2871	sodium ion transport
H7K60_RS17000	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7K60_RS17005	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7K60_RS17010	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7K60_RS17015	COG1805	sodium ion transport
H7K60_RS17020	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7K60_RS17030	COG0271	Belongs to the BolA IbaG family
H7K60_RS17035	COG2813	Specifically methylates the guanine in position
H7K60_RS17045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7K60_RS17055	COG2211	Major facilitator Superfamily
H7K60_RS17060	COG3248	Nucleoside-binding outer membrane protein
H7K60_RS17065	COG1666	GTP binding
H7K60_RS17070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7K60_RS17075	COG0693	protein deglycase activity
H7K60_RS17120	COG3501	Rhs element vgr protein
H7K60_RS17130	COG2771	luxR family
H7K60_RS17140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7K60_RS17140	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7K60_RS17145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7K60_RS17155	COG1151	hydroxylamine reductase activity
H7K60_RS17160	COG0783	Belongs to the Dps family
H7K60_RS17185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7K60_RS17200	COG4221	oxidoreductase activity
H7K60_RS17210	COG0415	Belongs to the DNA photolyase family
H7K60_RS17215	COG0789	Transcriptional regulator
H7K60_RS17220	COG3272	Protein of unknown function (DUF1722)
H7K60_RS17250	COG0077	Prephenate dehydratase
H7K60_RS17250	COG1605	Chorismate mutase
H7K60_RS17280	COG5377	YqaJ viral recombinase family
H7K60_RS17305	COG4584	PFAM Integrase catalytic
H7K60_RS17310	COG1484	DNA-dependent DNA replication
H7K60_RS17345	COG2003	Belongs to the UPF0758 family
H7K60_RS17365	COG0515	serine threonine protein kinase
H7K60_RS17365	COG2815	serine threonine protein kinase
H7K60_RS17410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7K60_RS17450	COG0840	transmembrane signaling receptor activity
H7K60_RS17460	COG0300	oxidoreductase activity
H7K60_RS17485	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H7K60_RS17500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7K60_RS17510	COG0826	peptidase U32
H7K60_RS17515	COG1280	lysine exporter protein (LysE YggA)
H7K60_RS17525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7K60_RS17530	COG0840	transmembrane signaling receptor activity
H7K60_RS17545	COG2198	Histidine kinase
H7K60_RS17545	COG0643	Histidine kinase
H7K60_RS17555	COG0835	chemotaxis
H7K60_RS17560	COG0840	transmembrane signaling receptor activity
H7K60_RS17570	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H7K60_RS17575	COG2201	protein-glutamate methylesterase activity
H7K60_RS17580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7K60_RS17610	COG2197	response regulator
H7K60_RS17615	COG3385	transposase activity
H7K60_RS17625	COG3188	usher protein
H7K60_RS17640	COG2199	diguanylate cyclase activity
H7K60_RS17640	COG2200	EAL domain
H7K60_RS17640	COG2203	Gaf domain
H7K60_RS17645	COG0826	peptidase U32
H7K60_RS17650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7K60_RS17660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7K60_RS17685	COG2200	EAL domain
H7K60_RS17690	COG0737	Belongs to the 5'-nucleotidase family
H7K60_RS17710	COG2204	response regulator
H7K60_RS17715	COG0545	Peptidyl-prolyl cis-trans isomerase
H7K60_RS17730	COG1047	Peptidyl-prolyl cis-trans
H7K60_RS17735	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H7K60_RS17745	COG0784	Response regulator, receiver
H7K60_RS17745	COG0835	chemotaxis
H7K60_RS17750	COG0429	hydrolase of the alpha beta-hydrolase fold
H7K60_RS17755	COG2203	Gaf domain
H7K60_RS17755	COG3706	GGDEF domain
H7K60_RS17755	COG4251	negative regulation of phosphorylation
H7K60_RS17755	COG5001	Diguanylate cyclase
H7K60_RS17760	COG3089	Belongs to the UPF0270 family
H7K60_RS17770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7K60_RS17775	COG0463	Glycosyl transferase, family 2
H7K60_RS17780	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7K60_RS17780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7K60_RS17785	COG0726	polysaccharide deacetylase
H7K60_RS17790	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H7K60_RS17795	COG2076	Multidrug Resistance protein
H7K60_RS17800	COG2076	Multidrug Resistance protein
H7K60_RS17805	COG3954	Phosphoribulokinase
H7K60_RS17820	COG1765	OsmC-like protein
H7K60_RS17830	COG2226	methyltransferase
H7K60_RS17835	COG3397	chitin binding
H7K60_RS17850	COG2202	Pas domain
H7K60_RS17850	COG2205	protein histidine kinase activity
H7K60_RS17860	COG3655	Transcriptional regulator
H7K60_RS17865	COG2814	Major facilitator Superfamily
H7K60_RS17870	COG4771	TonB-dependent receptor
H7K60_RS17890	COG0748	coenzyme F420 binding
H7K60_RS17895	COG3721	Heme iron utilization protein
H7K60_RS17905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7K60_RS17930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7K60_RS17935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7K60_RS17940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7K60_RS17960	COG0741	lytic transglycosylase activity
H7K60_RS17965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7K60_RS17980	COG0488	(ABC) transporter
H7K60_RS17990	COG2252	PERMEase
H7K60_RS17995	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7K60_RS18000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7K60_RS18005	COG3178	'Phosphotransferase
H7K60_RS18010	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7K60_RS18020	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7K60_RS18025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7K60_RS18030	COG2967	ApaG domain
H7K60_RS18035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7K60_RS18045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7K60_RS18050	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7K60_RS18065	COG0318	PFAM AMP-dependent synthetase and ligase
H7K60_RS18070	COG3314	Sporulation integral membrane protein YlbJ
H7K60_RS18075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7K60_RS18080	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7K60_RS18085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7K60_RS18090	COG0142	geranyltranstransferase activity
H7K60_RS18095	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H7K60_RS18100	COG0330	HflC and HflK could
H7K60_RS18105	COG0330	HflC and HflK could
H7K60_RS18110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7K60_RS18115	COG1923	regulation of RNA biosynthetic process
H7K60_RS18120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7K60_RS18125	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7K60_RS18135	COG0802	atpase or kinase
H7K60_RS18140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7K60_RS18140	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7K60_RS18145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7K60_RS18160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7K60_RS18165	COG2011	ABC-type metal ion transport system permease component
H7K60_RS18170	COG1464	Belongs to the NlpA lipoprotein family
H7K60_RS18180	COG0840	transmembrane signaling receptor activity
H7K60_RS18205	COG2198	Histidine kinase
H7K60_RS18205	COG5002	protein histidine kinase activity
H7K60_RS18205	COG0784	Response regulator, receiver
H7K60_RS18225	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H7K60_RS18240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7K60_RS18245	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H7K60_RS18255	COG2716	regulation of RNA biosynthetic process
H7K60_RS18260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7K60_RS18265	COG3013	Belongs to the UPF0304 family
H7K60_RS18275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7K60_RS18280	COG0857	belongs to the CobB CobQ family
H7K60_RS18280	COG0280	phosphate acetyltransferase
H7K60_RS18290	COG0028	Belongs to the TPP enzyme family
H7K60_RS18300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7K60_RS18305	COG0671	phosphoesterase, PA-phosphatase related
H7K60_RS18315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7K60_RS18320	COG0473	3-isopropylmalate dehydrogenase activity
H7K60_RS18325	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7K60_RS18330	COG0066	3-isopropylmalate dehydratase activity
H7K60_RS18345	COG4143	(ABC) transporter
H7K60_RS18350	COG1178	ABC-type Fe3 transport system permease component
H7K60_RS18355	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H7K60_RS18365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7K60_RS18375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7K60_RS18405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7K60_RS18410	COG0564	pseudouridine synthase activity
H7K60_RS18420	COG3300	MHYT domain
H7K60_RS18420	COG5001	Diguanylate cyclase
H7K60_RS18430	COG0459	protein refolding
H7K60_RS18435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7K60_RS18440	COG0534	Mate efflux family protein
H7K60_RS18445	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7K60_RS18450	COG1027	Aspartate ammonia-lyase
H7K60_RS18455	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7K60_RS18465	COG0477	Major facilitator Superfamily
H7K60_RS18480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7K60_RS18485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7K60_RS18495	COG0673	inositol 2-dehydrogenase activity
H7K60_RS18505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7K60_RS18510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7K60_RS18515	COG3036	rescue of stalled ribosome
H7K60_RS18530	COG0138	bifunctional purine biosynthesis protein purh
H7K60_RS18535	COG0151	Belongs to the GarS family
H7K60_RS18560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7K60_RS18565	COG0358	DNA primase activity
H7K60_RS18570	COG1610	YqeY-like protein
H7K60_RS18575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7K60_RS18580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7K60_RS18595	COG1238	metal cluster binding
H7K60_RS18600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7K60_RS18605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7K60_RS18610	COG0585	pseudouridine synthase activity
H7K60_RS18620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7K60_RS18625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7K60_RS18630	COG0148	phosphopyruvate hydratase activity
H7K60_RS18635	COG0504	CTP synthase activity
H7K60_RS18640	COG3956	TIGRFAM MazG family protein
H7K60_RS18645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7K60_RS18650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7K60_RS18660	COG4807	Protein conserved in bacteria
H7K60_RS18665	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7K60_RS18670	COG1349	DNA-binding transcription factor activity
H7K60_RS18680	COG2222	sugar isomerase
H7K60_RS18685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7K60_RS18695	COG3716	PTS system mannose fructose sorbose family IID component
H7K60_RS18700	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K60_RS18705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7K60_RS18720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7K60_RS18725	COG1381	Involved in DNA repair and RecF pathway recombination
H7K60_RS18735	COG0571	ribonuclease III activity
H7K60_RS18740	COG0681	Belongs to the peptidase S26 family
H7K60_RS18745	COG0481	GTPase activity
H7K60_RS18760	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H7K60_RS18765	COG1595	DNA-templated transcription, initiation
H7K60_RS18770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7K60_RS18780	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H7K60_RS18820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7K60_RS18830	COG0126	phosphoglycerate kinase activity
H7K60_RS18835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7K60_RS18840	COG1940	carbohydrate kinase activity
H7K60_RS18845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7K60_RS18860	COG4991	sh3 domain protein
H7K60_RS18865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7K60_RS18880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7K60_RS18885	COG1028	Short-chain dehydrogenase reductase Sdr
H7K60_RS18900	COG1505	serine-type exopeptidase activity
H7K60_RS18905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7K60_RS18910	COG0765	amino acid transport
H7K60_RS18915	COG0765	amino acid transport
H7K60_RS18920	COG1126	abc transporter atp-binding protein
H7K60_RS18925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K60_RS18930	COG0577	efflux transmembrane transporter activity
H7K60_RS18930	COG1136	(ABC) transporter
H7K60_RS18935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7K60_RS18940	COG0745	RESPONSE REGULATOR receiver
H7K60_RS18945	COG2205	protein histidine kinase activity
H7K60_RS18950	COG2816	NAD+ diphosphatase activity
H7K60_RS18985	COG2070	2-Nitropropane dioxygenase
H7K60_RS19010	COG1858	cytochrome C peroxidase
H7K60_RS19015	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
H7K60_RS19040	COG0513	Belongs to the DEAD box helicase family
H7K60_RS19065	COG0154	amidase activity
H7K60_RS19070	COG2957	Belongs to the agmatine deiminase family
H7K60_RS19080	COG2852	Protein conserved in bacteria
H7K60_RS19090	COG1902	pentaerythritol trinitrate reductase activity
H7K60_RS19135	COG0714	Associated with various cellular activities
H7K60_RS19145	COG0456	acetyltransferase
H7K60_RS19155	COG1022	Amp-dependent synthetase and ligase
H7K60_RS19165	COG2918	glutathione biosynthetic process
H7K60_RS19170	COG0612	Peptidase, M16
H7K60_RS19175	COG1238	metal cluster binding
H7K60_RS19200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K60_RS19205	COG0359	binds to the 23S rRNA
H7K60_RS19210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7K60_RS19215	COG0360	Binds together with S18 to 16S ribosomal RNA
H7K60_RS19220	COG1914	H( )-stimulated, divalent metal cation uptake system
H7K60_RS19225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7K60_RS19240	COG2153	protein acetylation
H7K60_RS19250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7K60_RS19255	COG0557	exoribonuclease II activity
H7K60_RS19260	COG3706	GGDEF domain
H7K60_RS19265	COG1854	S-ribosylhomocysteine lyase activity
H7K60_RS19280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7K60_RS19280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K60_RS19300	COG3385	transposase activity
H7K60_RS19330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7K60_RS19335	COG1047	Peptidyl-prolyl cis-trans
H7K60_RS19340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7K60_RS19345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7K60_RS19350	COG0196	riboflavin kinase activity
H7K60_RS19360	COG0728	peptidoglycan biosynthetic process
H7K60_RS19365	COG0268	Binds directly to 16S ribosomal RNA
H7K60_RS19370	COG0640	Transcriptional regulator
H7K60_RS19375	COG0583	DNA-binding transcription factor activity
H7K60_RS19385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7K60_RS19390	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7K60_RS19395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7K60_RS19405	COG1051	belongs to the nudix hydrolase family
H7K60_RS19410	COG3066	DNA modification
H7K60_RS19420	COG0335	large ribosomal subunit rRNA binding
H7K60_RS19425	COG0336	Belongs to the RNA methyltransferase TrmD family
H7K60_RS19430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7K60_RS19435	COG0228	four-way junction DNA binding
H7K60_RS19440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7K60_RS19445	COG4137	Cytochrome C assembly protein
H7K60_RS19450	COG4536	flavin adenine dinucleotide binding
H7K60_RS19455	COG1959	2 iron, 2 sulfur cluster binding
H7K60_RS19460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7K60_RS19460	COG1017	nitric oxide dioxygenase activity
H7K60_RS19465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H7K60_RS19470	COG0039	L-malate dehydrogenase activity
H7K60_RS19475	COG4160	amino acid transport
H7K60_RS19480	COG4215	(ABC) transporter
H7K60_RS19485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7K60_RS19490	COG1126	abc transporter atp-binding protein
H7K60_RS19495	COG1438	arginine binding
H7K60_RS19500	COG2837	iron assimilation
H7K60_RS19505	COG3842	ATPase activity
H7K60_RS19515	COG1840	ABC-type Fe3 transport system, periplasmic component
H7K60_RS19520	COG0347	Belongs to the P(II) protein family
H7K60_RS19535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7K60_RS19540	COG0583	DNA-binding transcription factor activity
H7K60_RS19555	COG1929	Belongs to the glycerate kinase type-1 family
H7K60_RS19560	COG2610	gluconate transmembrane transporter activity
H7K60_RS19565	COG3835	regulator
H7K60_RS19575	COG3112	Uncharacterised protein family (UPF0231)
H7K60_RS19590	COG0840	transmembrane signaling receptor activity
H7K60_RS19610	COG0513	Belongs to the DEAD box helicase family
H7K60_RS19650	COG1448	Aminotransferase
H7K60_RS19665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7K60_RS19670	COG1328	CTP reductase activity
H7K60_RS19690	COG4946	Tricorn protease homolog
H7K60_RS19690	COG0793	Belongs to the peptidase S41A family
H7K60_RS19725	COG3397	chitin binding
H7K60_RS19730	COG0583	DNA-binding transcription factor activity
H7K60_RS19735	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7K60_RS19740	COG4208	sulfate ABC transporter
H7K60_RS19745	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7K60_RS19755	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7K60_RS19760	COG3174	membrane
H7K60_RS19765	COG0110	maltose O-acetyltransferase activity
H7K60_RS19790	COG0165	Argininosuccinate lyase
H7K60_RS19795	COG0137	argininosuccinate synthase activity
H7K60_RS19805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7K60_RS19810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7K60_RS19820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7K60_RS19825	COG0527	aspartate kinase activity
H7K60_RS19825	COG0460	homoserine dehydrogenase
H7K60_RS19830	COG0626	cystathionine gamma-synthase activity
H7K60_RS19840	COG2207	Transcriptional regulator
H7K60_RS19840	COG3708	Transcriptional regulator
H7K60_RS19845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K60_RS19850	COG0814	amino acid
H7K60_RS19855	COG1218	3'(2'),5'-bisphosphate nucleotidase
H7K60_RS19860	COG0494	nUDIX hydrolase
H7K60_RS19865	COG1011	Hydrolase
H7K60_RS19870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7K60_RS19885	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H7K60_RS19895	COG3156	type II secretion system protein K
H7K60_RS19900	COG4795	General secretion pathway protein
H7K60_RS19905	COG2165	general secretion pathway protein
H7K60_RS19915	COG2165	general secretion pathway protein
H7K60_RS19920	COG1459	type II secretion system
H7K60_RS19925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7K60_RS19935	COG3031	protein transport across the cell outer membrane
H7K60_RS19945	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7K60_RS19950	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7K60_RS19970	COG0456	acetyltransferase
H7K60_RS19975	COG3133	Outer membrane lipoprotein
H7K60_RS19990	COG2771	luxR family
H7K60_RS19995	COG3916	Acyl-homoserine-lactone synthase
H7K60_RS20005	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H7K60_RS20010	COG1309	transcriptional regulator
H7K60_RS20020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7K60_RS20020	COG2213	PTS system mannitol-specific
H7K60_RS20025	COG0246	Mannitol dehydrogenase
H7K60_RS20030	COG3722	fumarate hydratase activity
H7K60_RS20035	COG3263	regulation of cellular component size
H7K60_RS20060	COG1671	Belongs to the UPF0178 family
H7K60_RS20075	COG1988	membrane-bound metal-dependent
H7K60_RS20080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7K60_RS20090	COG0513	Belongs to the DEAD box helicase family
H7K60_RS20115	COG1575	Belongs to the MenA family. Type 1 subfamily
H7K60_RS20120	COG1169	isochorismate synthase
H7K60_RS20125	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H7K60_RS20130	COG0596	Alpha beta hydrolase
H7K60_RS20135	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7K60_RS20140	COG1441	menaquinone biosynthetic process
H7K60_RS20145	COG0318	PFAM AMP-dependent synthetase and ligase
H7K60_RS20160	COG3539	Fimbrial protein
H7K60_RS20165	COG3121	Chaperone
H7K60_RS20170	COG3188	usher protein
H7K60_RS20180	COG3539	Fimbrial protein
H7K60_RS20190	COG3291	Pkd domain containing protein
H7K60_RS20195	COG2949	membrane
H7K60_RS20200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7K60_RS20210	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7K60_RS20215	COG5380	lipid catabolic process
H7K60_RS20230	COG4533	DNA binding
H7K60_RS20240	COG2873	o-acetylhomoserine
H7K60_RS20250	COG1979	alcohol dehydrogenase
H7K60_RS20270	COG4221	oxidoreductase activity
H7K60_RS20290	COG1285	pathogenesis
H7K60_RS20310	COG1368	sulfuric ester hydrolase activity
H7K60_RS20315	COG1522	sequence-specific DNA binding
H7K60_RS20325	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H7K60_RS20330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7K60_RS20335	COG1058	Belongs to the CinA family
H7K60_RS20335	COG1546	Belongs to the CinA family
H7K60_RS20345	COG0842	Transport permease protein
H7K60_RS20345	COG1129	ABC transporter
H7K60_RS20360	COG0561	phosphatase activity
H7K60_RS20365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7K60_RS20385	COG1011	Hydrolase
H7K60_RS20400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7K60_RS20405	COG0019	diaminopimelate decarboxylase activity
H7K60_RS20415	COG1965	Belongs to the frataxin family
H7K60_RS20420	COG0400	carboxylic ester hydrolase activity
H7K60_RS20425	COG3072	Adenylate cyclase
H7K60_RS20430	COG0181	hydroxymethylbilane synthase activity
H7K60_RS20440	COG2959	enzyme of heme biosynthesis
H7K60_RS20455	COG1494	fructose-1,6-bisphosphatase
H7K60_RS20495	COG1733	regulation of RNA biosynthetic process
H7K60_RS20515	COG3932	Exopolysaccharide synthesis, ExoD
H7K60_RS20520	COG0814	amino acid
H7K60_RS20525	COG3706	GGDEF domain
H7K60_RS20545	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
H7K60_RS20560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7K60_RS20565	COG2022	thiamine diphosphate biosynthetic process
H7K60_RS20575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7K60_RS20580	COG0352	thiamine-phosphate diphosphorylase activity
H7K60_RS20585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7K60_RS20610	COG0745	RESPONSE REGULATOR receiver
H7K60_RS20615	COG0642	Histidine kinase
H7K60_RS20625	COG0189	ligase activity
H7K60_RS20650	COG1639	'signal transduction protein
H7K60_RS20660	COG2321	neutral zinc metallopeptidase
H7K60_RS20665	COG3700	Belongs to the class B bacterial acid phosphatase family
H7K60_RS20690	COG2172	sigma factor antagonist activity
H7K60_RS20695	COG5002	protein histidine kinase activity
H7K60_RS20695	COG0784	Response regulator, receiver
H7K60_RS20695	COG2205	protein histidine kinase activity
H7K60_RS20700	COG3437	response regulator, receiver
H7K60_RS20710	COG0477	Major facilitator Superfamily
H7K60_RS20725	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H7K60_RS20730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7K60_RS20730	COG1263	PTS System
H7K60_RS20750	COG0312	modulator of DNA gyrase
H7K60_RS20755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7K60_RS20765	COG3164	Protein of unknown function
H7K60_RS20770	COG1530	ribonuclease E activity
H7K60_RS20775	COG0424	maF-like protein
H7K60_RS20780	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7K60_RS20785	COG1792	Involved in formation and maintenance of cell shape
H7K60_RS20790	COG1077	Cell shape determining protein MreB Mrl
H7K60_RS20825	COG2165	general secretion pathway protein
H7K60_RS20835	COG1459	type II secretion system
H7K60_RS20840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7K60_RS20885	COG2199	diguanylate cyclase activity
H7K60_RS20885	COG2200	EAL domain
H7K60_RS20890	COG2200	EAL domain
H7K60_RS20895	COG0387	Pfam Sodium calcium exchanger
H7K60_RS20900	COG2986	histidine ammonia-lyase
H7K60_RS20905	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7K60_RS20910	COG0010	Belongs to the arginase family
H7K60_RS20915	COG1228	amidohydrolase
H7K60_RS20920	COG2188	Transcriptional regulator
H7K60_RS20925	COG0288	reversible hydration of carbon dioxide
H7K60_RS20935	COG2177	Part of the ABC transporter FtsEX involved in
H7K60_RS20940	COG2884	Cell division ATP-binding protein ftsE
H7K60_RS20945	COG0552	protein localization to endoplasmic reticulum
H7K60_RS20950	COG0742	ribosomal rna small subunit methyltransferase
H7K60_RS20975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7K60_RS20985	COG0741	lytic transglycosylase activity
H7K60_RS20995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7K60_RS21005	COG2095	MarC family integral membrane protein
H7K60_RS21015	COG1301	dicarboxylic acid transport
H7K60_RS21040	COG3714	YhhN family
H7K60_RS21060	COG1770	oligopeptidase
H7K60_RS21075	COG4221	oxidoreductase activity
H7K60_RS21080	COG0583	DNA-binding transcription factor activity
H7K60_RS21085	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7K60_RS21130	COG0203	ribosomal protein L17
H7K60_RS21135	COG0202	RNA polymerase activity
H7K60_RS21140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7K60_RS21145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7K60_RS21150	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7K60_RS21155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7K60_RS21160	COG0201	protein transport
H7K60_RS21165	COG0200	Binds to the 23S rRNA
H7K60_RS21170	COG1841	ribosomal large subunit assembly
H7K60_RS21175	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7K60_RS21180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7K60_RS21185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7K60_RS21190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7K60_RS21195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7K60_RS21200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7K60_RS21205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7K60_RS21210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7K60_RS21215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7K60_RS21220	COG0255	Belongs to the universal ribosomal protein uL29 family
H7K60_RS21225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7K60_RS21230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7K60_RS21235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7K60_RS21240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7K60_RS21245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7K60_RS21250	COG0089	rRNA binding
H7K60_RS21255	COG0088	Forms part of the polypeptide exit tunnel
H7K60_RS21260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7K60_RS21265	COG0051	transcription antitermination factor activity, RNA binding
H7K60_RS21285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7K60_RS21290	COG2183	response to ionizing radiation
H7K60_RS21310	COG0596	Alpha beta hydrolase
H7K60_RS21315	COG1040	competence protein
H7K60_RS21320	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7K60_RS21320	COG0316	Belongs to the HesB IscA family
H7K60_RS21325	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7K60_RS21330	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7K60_RS21335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7K60_RS21340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7K60_RS21345	COG4942	peptidase
H7K60_RS21355	COG1609	Transcriptional regulator
H7K60_RS21360	COG0800	Aldolase
H7K60_RS21365	COG0129	dihydroxy-acid dehydratase activity
H7K60_RS21370	COG3265	gluconokinase activity
H7K60_RS21375	COG2610	gluconate transmembrane transporter activity
H7K60_RS21380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7K60_RS21385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7K60_RS21395	COG0456	acetyltransferase
H7K60_RS21405	COG1490	D-aminoacyl-tRNA deacylase activity
H7K60_RS21410	COG1295	ribonuclease BN
H7K60_RS21415	COG1295	ribonuclease BN
H7K60_RS21420	COG1217	gtp-binding protein TYPA
H7K60_RS21425	COG0174	glutamine synthetase
H7K60_RS21435	COG3852	Histidine kinase
H7K60_RS21440	COG2204	response regulator
H7K60_RS21445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7K60_RS21450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7K60_RS21460	COG3078	GTPase activator activity
H7K60_RS21470	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7K60_RS21480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7K60_RS21485	COG0408	coproporphyrinogen oxidase activity
H7K60_RS21490	COG0009	L-threonylcarbamoyladenylate synthase
H7K60_RS21500	COG0551	DNA topoisomerase type I activity
H7K60_RS21505	COG2922	Belongs to the Smg family
H7K60_RS21510	COG0758	DNA mediated transformation
H7K60_RS21520	COG0242	peptide deformylase activity
H7K60_RS21525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7K60_RS21530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7K60_RS21530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7K60_RS21535	COG0569	domain protein
H7K60_RS21540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7K60_RS21545	COG1322	Protein conserved in bacteria
H7K60_RS21565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7K60_RS21570	COG0686	Belongs to the AlaDH PNT family
H7K60_RS21575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7K60_RS21575	COG0519	Catalyzes the synthesis of GMP from XMP
H7K60_RS21585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7K60_RS21590	COG1396	sequence-specific DNA binding
H7K60_RS21595	COG1012	belongs to the aldehyde dehydrogenase family
H7K60_RS21605	COG2962	Rard protein
H7K60_RS21615	COG1280	lysine exporter protein (LysE YggA)
H7K60_RS21625	COG0840	transmembrane signaling receptor activity
H7K60_RS21630	COG2391	methyltransferase activity
H7K60_RS21635	COG1280	lysine exporter protein (LysE YggA)
H7K60_RS21690	COG0583	DNA-binding transcription factor activity
H7K60_RS21715	COG0210	DNA helicase
H7K60_RS21730	COG1744	ABC transporter substrate-binding protein PnrA-like
H7K60_RS21735	COG3845	ABC transporter
H7K60_RS21740	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7K60_RS21745	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7K60_RS21750	COG0583	DNA-binding transcription factor activity
H7K60_RS21770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7K60_RS21775	COG0385	Bile acid
H7K60_RS21780	COG0531	amino acid
H7K60_RS21785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7K60_RS21790	COG0531	amino acid
H7K60_RS21795	COG2731	YhcH YjgK YiaL family protein
H7K60_RS21800	COG3250	beta-galactosidase activity
H7K60_RS21805	COG1609	Transcriptional regulator
H7K60_RS21840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7K60_RS21845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7K60_RS21845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7K60_RS21850	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H7K60_RS21855	COG3074	FtsZ-dependent cytokinesis
H7K60_RS21865	COG1045	serine acetyltransferase
H7K60_RS21875	COG0745	RESPONSE REGULATOR receiver
H7K60_RS21880	COG2205	protein histidine kinase activity
H7K60_RS21885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7K60_RS21890	COG0534	Mate efflux family protein
H7K60_RS21905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7K60_RS21910	COG2937	Belongs to the GPAT DAPAT family
H7K60_RS21915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7K60_RS21920	COG3161	chorismate lyase activity
H7K60_RS21925	COG1580	Controls the rotational direction of flagella during chemotaxis
H7K60_RS21940	COG0604	alcohol dehydrogenase
H7K60_RS21945	COG1609	Transcriptional regulator
H7K60_RS21965	COG1519	Transferase
H7K60_RS21970	COG0859	PFAM glycosyl transferase family 9
H7K60_RS21975	COG0463	Glycosyl transferase, family 2
H7K60_RS21980	COG0859	PFAM glycosyl transferase family 9
H7K60_RS21985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7K60_RS21990	COG2990	Protein conserved in bacteria
H7K60_RS21995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7K60_RS22005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7K60_RS22010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7K60_RS22015	COG2003	Belongs to the UPF0758 family
H7K60_RS22020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7K60_RS22025	COG0756	dUTP diphosphatase activity
H7K60_RS22030	COG1309	transcriptional regulator
H7K60_RS22035	COG0668	transmembrane transport
H7K60_RS22045	COG0166	Belongs to the GPI family
H7K60_RS22050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7K60_RS22055	COG0583	DNA-binding transcription factor activity
H7K60_RS22100	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H7K60_RS22105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7K60_RS22110	COG1739	Uncharacterized protein family UPF0029
H7K60_RS22115	COG0006	proline dipeptidase activity
H7K60_RS22120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7K60_RS22125	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7K60_RS22125	COG1024	Enoyl-CoA hydratase
H7K60_RS22130	COG0183	Belongs to the thiolase family
H7K60_RS22155	COG0425	Belongs to the sulfur carrier protein TusA family
H7K60_RS22160	COG0251	oxidation-reduction process
H7K60_RS22165	COG2885	chlorophyll binding
H7K60_RS22175	COG2818	Glycosylase
H7K60_RS22180	COG0752	glycyl-tRNA synthetase alpha subunit
H7K60_RS22185	COG0751	glycine-tRNA ligase activity
H7K60_RS22195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7K60_RS22205	COG0583	DNA-binding transcription factor activity
H7K60_RS22225	COG0814	amino acid
H7K60_RS22230	COG0348	domain, Protein
H7K60_RS22240	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7K60_RS22245	COG0426	domain, Protein
H7K60_RS22245	COG1773	rubredoxin
H7K60_RS22250	COG3604	Transcriptional regulator
H7K60_RS22255	COG2188	Transcriptional regulator
H7K60_RS22270	COG1609	Transcriptional regulator
H7K60_RS22310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7K60_RS22335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7K60_RS22350	COG3118	belongs to the thioredoxin family
H7K60_RS22355	COG0513	Belongs to the DEAD box helicase family
H7K60_RS22360	COG0248	Ppx GppA phosphatase
H7K60_RS22370	COG0742	ribosomal rna small subunit methyltransferase
H7K60_RS22390	COG0084	hydrolase, TatD family'
H7K60_RS22395	COG0805	protein transport
H7K60_RS22400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7K60_RS22410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7K60_RS22415	COG3165	ubiquinone biosynthetic process from chorismate
H7K60_RS22425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7K60_RS22430	COG0402	S-adenosylhomocysteine deaminase activity
H7K60_RS22475	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H7K60_RS22480	COG0848	biopolymer transport protein
H7K60_RS22485	COG0811	peptide transport
H7K60_RS22490	COG0811	peptide transport
H7K60_RS22500	COG2771	luxR family
H7K60_RS22505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7K60_RS22510	COG1349	DNA-binding transcription factor activity
H7K60_RS22515	COG0745	RESPONSE REGULATOR receiver
H7K60_RS22520	COG2205	protein histidine kinase activity
H7K60_RS22530	COG4452	Inner membrane protein CreD
H7K60_RS22535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7K60_RS22540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7K60_RS22545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7K60_RS22550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7K60_RS22555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7K60_RS22560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7K60_RS22565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7K60_RS22575	COG0356	it plays a direct role in the translocation of protons across the membrane
H7K60_RS22585	COG1475	DNA binding
H7K60_RS22590	COG1192	Involved in chromosome partitioning
H7K60_RS22595	COG0357	Ribosomal RNA small subunit methyltransferase G
H7K60_RS22600	COG0445	tRNA wobble uridine modification
H7K60_RS22605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7K60_RS22610	COG4774	siderophore transport
H7K60_RS22615	COG4615	Cyclic peptide transporter
H7K60_RS22620	COG1120	ATPase activity
H7K60_RS22635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7K60_RS22640	COG0706	membrane insertase activity
H7K60_RS22645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7K60_RS22650	COG0594	ribonuclease P activity
H7K60_RS22655	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7K60_RS22660	COG1126	abc transporter atp-binding protein