locus-tag	class	description
AI20_RS00015	COG1185	polyribonucleotide nucleotidyltransferase activity
AI20_RS00020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AI20_RS00025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AI20_RS00030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AI20_RS00035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AI20_RS00040	COG0195	Participates in both transcription termination and antitermination
AI20_RS00045	COG0779	Required for maturation of 30S ribosomal subunits
AI20_RS00060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AI20_RS00065	COG0149	triose-phosphate isomerase activity
AI20_RS00070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AI20_RS00075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AI20_RS00085	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AI20_RS00090	COG1534	Rna-binding protein
AI20_RS00105	COG1360	Flagellar Motor Protein
AI20_RS00110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AI20_RS00115	COG1722	exodeoxyribonuclease VII activity
AI20_RS00120	COG0142	geranyltranstransferase activity
AI20_RS00125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AI20_RS00130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AI20_RS00135	COG0601	transmembrane transport
AI20_RS00145	COG4172	Belongs to the ABC transporter superfamily
AI20_RS00150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AI20_RS00155	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AI20_RS00160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AI20_RS00180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AI20_RS00180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AI20_RS00185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AI20_RS00200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AI20_RS00210	COG0784	Response regulator, receiver
AI20_RS00210	COG2205	protein histidine kinase activity
AI20_RS00210	COG2198	Histidine kinase
AI20_RS00215	COG1879	ABC-type sugar transport system periplasmic component
AI20_RS00225	COG0745	RESPONSE REGULATOR receiver
AI20_RS00230	COG3005	denitrification pathway
AI20_RS00240	COG3381	protein complex oligomerization
AI20_RS00260	COG5001	Diguanylate cyclase
AI20_RS00260	COG3300	MHYT domain
AI20_RS00270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AI20_RS00275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AI20_RS00280	COG0511	ligase activity, forming carbon-carbon bonds
AI20_RS00285	COG0439	Biotin carboxylase
AI20_RS00290	COG3924	membrane
AI20_RS00295	COG4145	pantothenate transmembrane transporter activity
AI20_RS00300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AI20_RS00300	COG2190	(PTS) system
AI20_RS00300	COG1263	PTS System
AI20_RS00305	COG0583	DNA-binding transcription factor activity
AI20_RS00310	COG0604	alcohol dehydrogenase
AI20_RS00315	COG2264	protein methyltransferase activity
AI20_RS00320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AI20_RS00330	COG0778	Nitroreductase
AI20_RS00340	COG0446	pyridine nucleotide-disulphide oxidoreductase
AI20_RS00340	COG1902	pentaerythritol trinitrate reductase activity
AI20_RS00345	COG0616	signal peptide processing
AI20_RS00365	COG3139	Protein of unknown function (DUF1315)
AI20_RS00370	COG0252	asparaginase activity
AI20_RS00375	COG0786	glutamate:sodium symporter activity
AI20_RS00385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AI20_RS00390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AI20_RS00400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AI20_RS00405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AI20_RS00410	COG0175	sulfate reduction
AI20_RS00415	COG2113	Glycine betaine
AI20_RS00420	COG4176	ABC-type proline glycine betaine transport system permease component
AI20_RS00425	COG4175	Glycine betaine
AI20_RS00445	COG3610	response to peptide
AI20_RS00450	COG2966	Psort location CytoplasmicMembrane, score
AI20_RS00460	COG0521	Mo-molybdopterin cofactor biosynthetic process
AI20_RS00470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AI20_RS00475	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_RS00485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AI20_RS00510	COG2986	histidine ammonia-lyase
AI20_RS00520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AI20_RS00535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AI20_RS00540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AI20_RS00575	COG1858	cytochrome C peroxidase
AI20_RS00585	COG2313	pseudouridylate synthase activity
AI20_RS00590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AI20_RS00620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AI20_RS00635	COG1073	alpha beta
AI20_RS00640	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AI20_RS00645	COG2195	Cleaves the N-terminal amino acid of tripeptides
AI20_RS00650	COG4608	Belongs to the ABC transporter superfamily
AI20_RS00655	COG0444	Belongs to the ABC transporter superfamily
AI20_RS00665	COG4239	(ABC) transporter, permease
AI20_RS00670	COG4174	ABC transporter (Permease)
AI20_RS00685	COG0811	peptide transport
AI20_RS00690	COG0811	peptide transport
AI20_RS00695	COG0848	biopolymer transport protein
AI20_RS00750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AI20_RS00755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AI20_RS00760	COG0840	transmembrane signaling receptor activity
AI20_RS00770	COG1278	Cold shock
AI20_RS00805	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AI20_RS00810	COG1162	GTPase activity
AI20_RS00815	COG0688	phosphatidylethanolamine metabolic process
AI20_RS00820	COG4628	conserved protein (DUF2132)
AI20_RS00840	COG3300	MHYT domain
AI20_RS00840	COG5001	Diguanylate cyclase
AI20_RS00845	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AI20_RS00870	COG1132	(ABC) transporter
AI20_RS00880	COG1404	Belongs to the peptidase S8 family
AI20_RS00885	COG2897	thiosulfate sulfurtransferase activity
AI20_RS00890	COG2066	Belongs to the glutaminase family
AI20_RS00895	COG3171	Protein conserved in bacteria
AI20_RS00900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AI20_RS00905	COG4935	Belongs to the peptidase S8 family
AI20_RS00905	COG2234	aminopeptidase activity
AI20_RS00910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AI20_RS00915	COG2200	EAL domain
AI20_RS00920	COG1090	epimerase
AI20_RS00925	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AI20_RS00930	COG4181	ATPase activity
AI20_RS00935	COG2755	lipolytic protein G-D-S-L family
AI20_RS00940	COG0835	chemotaxis
AI20_RS00940	COG0784	Response regulator, receiver
AI20_RS00950	COG0569	domain protein
AI20_RS00950	COG2985	domain, Protein
AI20_RS00955	COG1272	protein, Hemolysin III
AI20_RS00960	COG0076	glutamate decarboxylase activity
AI20_RS00965	COG2917	probably involved in intracellular septation
AI20_RS00970	COG2350	Protein conserved in bacteria
AI20_RS00980	COG1555	photosystem II stabilization
AI20_RS00985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AI20_RS00990	COG3104	oligopeptide transport
AI20_RS00995	COG0745	RESPONSE REGULATOR receiver
AI20_RS01025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_RS01040	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AI20_RS01070	COG0316	Belongs to the HesB IscA family
AI20_RS01080	COG0038	chloride channel
AI20_RS01085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AI20_RS01100	COG0671	phosphoesterase, PA-phosphatase related
AI20_RS01110	COG3437	response regulator, receiver
AI20_RS01110	COG0784	Response regulator, receiver
AI20_RS01120	COG2076	Multidrug Resistance protein
AI20_RS01130	COG0346	lactoylglutathione lyase activity
AI20_RS01135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AI20_RS01140	COG1643	Atp-dependent helicase
AI20_RS01150	COG1489	DNA binding
AI20_RS01155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AI20_RS01160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AI20_RS01165	COG0617	tRNA 3'-terminal CCA addition
AI20_RS01170	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AI20_RS01175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AI20_RS01180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AI20_RS01200	COG1924	4 iron, 4 sulfur cluster binding
AI20_RS01205	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AI20_RS01210	COG0842	Transport permease protein
AI20_RS01215	COG1131	(ABC) transporter
AI20_RS01230	COG0163	prenyltransferase activity
AI20_RS01235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AI20_RS01240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AI20_RS01255	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AI20_RS01270	COG1136	(ABC) transporter
AI20_RS01290	COG0840	transmembrane signaling receptor activity
AI20_RS01305	COG0529	Catalyzes the synthesis of activated sulfate
AI20_RS01310	COG0471	metal ion transport
AI20_RS01310	COG3273	potassium ion transport
AI20_RS01315	COG2895	sulfate adenylyltransferase (ATP) activity
AI20_RS01320	COG0175	sulfate reduction
AI20_RS01325	COG1648	precorrin-2 dehydrogenase activity
AI20_RS01325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AI20_RS01330	COG0330	HflC and HflK could
AI20_RS01335	COG1585	Membrane protein implicated in regulation of membrane protease activity
AI20_RS01340	COG0517	IMP dehydrogenase activity
AI20_RS01340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AI20_RS01345	COG0488	(ABC) transporter
AI20_RS01355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AI20_RS01395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AI20_RS01405	COG0668	transmembrane transport
AI20_RS01415	COG2731	YhcH YjgK YiaL family protein
AI20_RS01430	COG1794	racemase activity, acting on amino acids and derivatives
AI20_RS01445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AI20_RS01470	COG0733	neurotransmitter:sodium symporter activity
AI20_RS01480	COG0733	neurotransmitter:sodium symporter activity
AI20_RS01495	COG0561	phosphatase activity
AI20_RS01525	COG1846	Transcriptional regulator
AI20_RS01530	COG2130	NADP-dependent
AI20_RS01535	COG1051	belongs to the nudix hydrolase family
AI20_RS01555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AI20_RS01560	COG1640	4-alpha-glucanotransferase
AI20_RS01565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AI20_RS01570	COG0676	glucose-6-phosphate 1-epimerase activity
AI20_RS01575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AI20_RS01580	COG0840	transmembrane signaling receptor activity
AI20_RS01655	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AI20_RS01660	COG2885	chlorophyll binding
AI20_RS01665	COG0823	Involved in the tonB-independent uptake of proteins
AI20_RS01680	COG0811	peptide transport
AI20_RS01685	COG0824	Thioesterase
AI20_RS01690	COG3790	cyd operon protein YbgE
AI20_RS01695	COG4890	Cyd operon protein YbgT
AI20_RS01700	COG1294	oxidase, subunit
AI20_RS01705	COG1271	oxidase subunit
AI20_RS01710	COG2255	four-way junction helicase activity
AI20_RS01715	COG0632	four-way junction helicase activity
AI20_RS01720	COG0840	transmembrane signaling receptor activity
AI20_RS01725	COG0442	prolyl-tRNA aminoacylation
AI20_RS01730	COG4221	oxidoreductase activity
AI20_RS01745	COG1024	Enoyl-CoA hydratase
AI20_RS01755	COG0110	maltose O-acetyltransferase activity
AI20_RS01765	COG4166	transmembrane transport
AI20_RS01780	COG1872	DUF167
AI20_RS01785	COG0762	integral membrane protein
AI20_RS01790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AI20_RS01795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AI20_RS01810	COG3022	response to hydroperoxide
AI20_RS01815	COG0513	Belongs to the DEAD box helicase family
AI20_RS01820	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AI20_RS01850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AI20_RS01860	COG0776	regulation of translation
AI20_RS01890	COG0560	Phosphoserine phosphatase
AI20_RS01900	COG5002	protein histidine kinase activity
AI20_RS01900	COG5001	Diguanylate cyclase
AI20_RS01900	COG3447	MASE1 domain protein
AI20_RS01905	COG0813	purine-nucleoside phosphorylase activity
AI20_RS01910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AI20_RS01915	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AI20_RS01920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AI20_RS01930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AI20_RS01935	COG0084	hydrolase, TatD family'
AI20_RS01950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AI20_RS01955	COG0004	ammonium transporteR
AI20_RS01970	COG0795	lipopolysaccharide-transporting ATPase activity
AI20_RS01975	COG0795	lipopolysaccharide-transporting ATPase activity
AI20_RS01980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AI20_RS01985	COG2927	DNA polymerase III (CHI subunit)
AI20_RS01990	COG0525	valine-tRNA ligase activity
AI20_RS01995	COG1253	flavin adenine dinucleotide binding
AI20_RS02000	COG0586	Pfam SNARE associated Golgi protein
AI20_RS02005	COG1686	Belongs to the peptidase S11 family
AI20_RS02040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AI20_RS02045	COG0527	aspartate kinase activity
AI20_RS02050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AI20_RS02060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AI20_RS02065	COG1546	Belongs to the CinA family
AI20_RS02075	COG5377	YqaJ viral recombinase family
AI20_RS02110	COG2003	Belongs to the UPF0758 family
AI20_RS02115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AI20_RS02140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AI20_RS02180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AI20_RS02205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AI20_RS02225	COG3068	Protein conserved in bacteria
AI20_RS02235	COG0739	heme binding
AI20_RS02255	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AI20_RS02260	COG1121	(ABC) transporter
AI20_RS02265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AI20_RS02270	COG0583	DNA-binding transcription factor activity
AI20_RS02275	COG0697	spore germination
AI20_RS02280	COG1573	uracil-dna glycosylase
AI20_RS02285	COG2962	Rard protein
AI20_RS02295	COG2827	Endonuclease containing a URI domain
AI20_RS02310	COG1842	Phage shock protein A
AI20_RS02315	COG0204	Acyl-transferase
AI20_RS02335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AI20_RS02380	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AI20_RS02390	COG0583	DNA-binding transcription factor activity
AI20_RS02405	COG1289	transmembrane transporter activity
AI20_RS02410	COG1566	PFAM secretion protein HlyD family protein
AI20_RS02425	COG1051	belongs to the nudix hydrolase family
AI20_RS02430	COG3150	esterase
AI20_RS02440	COG3151	Protein conserved in bacteria
AI20_RS02445	COG0494	nUDIX hydrolase
AI20_RS02450	COG1538	Outer membrane efflux protein
AI20_RS02455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AI20_RS02455	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AI20_RS02460	COG1560	Kdo2-lipid A biosynthetic process
AI20_RS02475	COG1392	Phosphate transport regulator
AI20_RS02480	COG0306	phosphate transporter
AI20_RS02485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AI20_RS02515	COG0583	DNA-binding transcription factor activity
AI20_RS02520	COG1380	Effector of murein hydrolase LrgA
AI20_RS02525	COG1346	cytolysis
AI20_RS02540	COG0617	tRNA 3'-terminal CCA addition
AI20_RS02545	COG3409	Peptidoglycan-binding domain 1 protein
AI20_RS02545	COG3267	Type II secretory pathway component ExeA
AI20_RS02555	COG1194	a g-specific adenine glycosylase
AI20_RS02560	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AI20_RS02570	COG3111	PFAM Bacterial OB fold (BOF) protein
AI20_RS02575	COG3240	lipase activity
AI20_RS02590	COG3009	Protein conserved in bacteria
AI20_RS02595	COG3008	intermembrane lipid transfer
AI20_RS02595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AI20_RS02600	COG2995	paraquat-inducible protein a
AI20_RS02610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AI20_RS02620	COG5001	Diguanylate cyclase
AI20_RS02620	COG2203	Gaf domain
AI20_RS02620	COG4251	negative regulation of phosphorylation
AI20_RS02620	COG3706	GGDEF domain
AI20_RS02625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AI20_RS02630	COG2813	Specifically methylates the guanine in position
AI20_RS02635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AI20_RS02640	COG0297	glycogen (starch) synthase activity
AI20_RS02680	COG1757	Na H antiporter
AI20_RS02685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AI20_RS02690	COG3842	ATPase activity
AI20_RS02695	COG1176	ABC-type spermidine putrescine transport system, permease component I
AI20_RS02700	COG1177	transmembrane transport
AI20_RS02705	COG1012	belongs to the aldehyde dehydrogenase family
AI20_RS02730	COG0110	maltose O-acetyltransferase activity
AI20_RS02735	COG0366	Alpha amylase catalytic
AI20_RS02740	COG1263	PTS System
AI20_RS02740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AI20_RS02760	COG0252	asparaginase activity
AI20_RS02775	COG1803	Methylglyoxal synthase
AI20_RS02800	COG1444	tRNA N-acetyltransferase activity
AI20_RS02810	COG0835	chemotaxis
AI20_RS02810	COG0784	Response regulator, receiver
AI20_RS02815	COG3314	Sporulation integral membrane protein YlbJ
AI20_RS02850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AI20_RS02855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AI20_RS02870	COG0477	Major facilitator Superfamily
AI20_RS02875	COG0523	cobalamin synthesis protein
AI20_RS02885	COG1280	lysine exporter protein (LysE YggA)
AI20_RS02895	COG2200	EAL domain
AI20_RS02900	COG1049	propionate catabolic process, 2-methylcitrate cycle
AI20_RS02905	COG1752	Esterase of the alpha-beta hydrolase superfamily
AI20_RS02910	COG0840	transmembrane signaling receptor activity
AI20_RS02915	COG0840	transmembrane signaling receptor activity
AI20_RS02925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AI20_RS02930	COG0508	dehydrogenase complex catalyzes the overall conversion of
AI20_RS02935	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AI20_RS02940	COG2186	Transcriptional regulator
AI20_RS02965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AI20_RS02970	COG1459	type II secretion system
AI20_RS02985	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AI20_RS02990	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AI20_RS02995	COG0494	nUDIX hydrolase
AI20_RS03005	COG0653	protein targeting
AI20_RS03015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AI20_RS03020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AI20_RS03025	COG0849	cell division
AI20_RS03030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AI20_RS03035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AI20_RS03040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AI20_RS03045	COG0772	Belongs to the SEDS family
AI20_RS03050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AI20_RS03055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AI20_RS03060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AI20_RS03070	COG0768	penicillin binding
AI20_RS03075	COG3116	cell division
AI20_RS03080	COG0275	rRNA processing
AI20_RS03085	COG2001	Belongs to the MraZ family
AI20_RS03095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AI20_RS03100	COG3107	peptidoglycan biosynthetic process
AI20_RS03105	COG0792	nuclease activity
AI20_RS03110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AI20_RS03115	COG2823	Periplasmic or secreted lipoprotein
AI20_RS03120	COG2969	positive regulation of protein catabolic process
AI20_RS03125	COG0625	glutathione transferase activity
AI20_RS03130	COG2857	Cytochrome c1
AI20_RS03135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AI20_RS03140	COG0723	plastoquinol--plastocyanin reductase activity
AI20_RS03145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AI20_RS03150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AI20_RS03155	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AI20_RS03165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AI20_RS03170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AI20_RS03200	COG3964	amidohydrolase
AI20_RS03215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_RS03215	COG3711	transcriptional antiterminator
AI20_RS03220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_RS03225	COG1660	Displays ATPase and GTPase activities
AI20_RS03230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_RS03240	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AI20_RS03245	COG1137	ATPase activity
AI20_RS03250	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AI20_RS03255	COG3117	lipopolysaccharide transmembrane transporter activity
AI20_RS03260	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AI20_RS03265	COG0517	IMP dehydrogenase activity
AI20_RS03265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AI20_RS03270	COG1127	ABC transporter
AI20_RS03275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AI20_RS03280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AI20_RS03285	COG2854	intermembrane phospholipid transfer
AI20_RS03295	COG5007	Belongs to the BolA IbaG family
AI20_RS03300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AI20_RS03305	COG0312	modulator of DNA gyrase
AI20_RS03310	COG3028	Belongs to the UPF0307 family
AI20_RS03320	COG2926	Belongs to the UPF0265 family
AI20_RS03350	COG1396	sequence-specific DNA binding
AI20_RS03355	COG3135	benzoate transporter
AI20_RS03380	COG0840	transmembrane signaling receptor activity
AI20_RS03385	COG3047	cAMP biosynthetic process
AI20_RS03395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AI20_RS03400	COG2197	response regulator
AI20_RS03435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AI20_RS03490	COG4771	TonB-dependent receptor
AI20_RS03495	COG4251	negative regulation of phosphorylation
AI20_RS03495	COG5001	Diguanylate cyclase
AI20_RS03495	COG3706	GGDEF domain
AI20_RS03495	COG2203	Gaf domain
AI20_RS03535	COG0346	lactoylglutathione lyase activity
AI20_RS03540	COG0583	DNA-binding transcription factor activity
AI20_RS03545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AI20_RS03550	COG1074	ATP-dependent DNA helicase activity
AI20_RS03555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AI20_RS03560	COG2259	Doxx family
AI20_RS03565	COG1741	Belongs to the pirin family
AI20_RS03575	COG0583	DNA-binding transcription factor activity
AI20_RS03600	COG1175	transmembrane transport
AI20_RS03610	COG3842	ATPase activity
AI20_RS03620	COG3706	GGDEF domain
AI20_RS03640	COG1247	-acetyltransferase
AI20_RS03670	COG0628	permease
AI20_RS03675	COG4221	oxidoreductase activity
AI20_RS03680	COG2957	Belongs to the agmatine deiminase family
AI20_RS03690	COG3284	Transcriptional regulator
AI20_RS03705	COG1461	Dihydroxyacetone kinase
AI20_RS03710	COG2376	Dihydroxyacetone kinase
AI20_RS03715	COG2252	PERMEase
AI20_RS03750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AI20_RS03755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AI20_RS03760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AI20_RS03765	COG0049	tRNA binding
AI20_RS03775	COG2168	tRNA wobble position uridine thiolation
AI20_RS03790	COG0251	oxidation-reduction process
AI20_RS03795	COG2964	Protein conserved in bacteria
AI20_RS03800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AI20_RS03805	COG0085	RNA polymerase activity
AI20_RS03810	COG0222	ribosome binding
AI20_RS03815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AI20_RS03820	COG0081	regulation of translation
AI20_RS03825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AI20_RS03830	COG0250	Participates in transcription elongation, termination and antitermination
AI20_RS03845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AI20_RS03870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AI20_RS03875	COG0569	domain protein
AI20_RS03880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AI20_RS03900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AI20_RS03905	COG3005	denitrification pathway
AI20_RS03910	COG0243	molybdopterin cofactor binding
AI20_RS03940	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AI20_RS03955	COG2204	response regulator
AI20_RS03965	COG2205	protein histidine kinase activity
AI20_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_RS03980	COG0517	IMP dehydrogenase activity
AI20_RS03980	COG0516	GMP reductase activity
AI20_RS03985	COG5413	integral membrane protein
AI20_RS03995	COG1522	sequence-specific DNA binding
AI20_RS04000	COG2502	aspartate--ammonia ligase
AI20_RS04005	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AI20_RS04010	COG0542	response to heat
AI20_RS04020	COG0564	pseudouridine synthase activity
AI20_RS04025	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AI20_RS04030	COG0446	pyridine nucleotide-disulphide oxidoreductase
AI20_RS04040	COG3681	Belongs to the UPF0597 family
AI20_RS04045	COG2964	Protein conserved in bacteria
AI20_RS04050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AI20_RS04055	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AI20_RS04060	COG1979	alcohol dehydrogenase
AI20_RS04065	COG2207	Transcriptional regulator
AI20_RS04070	COG3040	lipid binding
AI20_RS04085	COG0688	phosphatidylethanolamine metabolic process
AI20_RS04100	COG0540	Belongs to the ATCase OTCase family
AI20_RS04105	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AI20_RS04110	COG1438	arginine binding
AI20_RS04115	COG1288	antiporter activity
AI20_RS04120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AI20_RS04165	COG3250	beta-galactosidase activity
AI20_RS04170	COG1609	Transcriptional regulator
AI20_RS04175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AI20_RS04185	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AI20_RS04190	COG2017	converts alpha-aldose to the beta-anomer
AI20_RS04195	COG0667	Aldo Keto reductase
AI20_RS04200	COG1968	undecaprenyl-diphosphatase activity
AI20_RS04205	COG3806	Anti-sigma factor
AI20_RS04210	COG1595	DNA-templated transcription, initiation
AI20_RS04230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AI20_RS04235	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AI20_RS04240	COG0477	Major facilitator Superfamily
AI20_RS04250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AI20_RS04260	COG2116	formate transmembrane transporter activity
AI20_RS04265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AI20_RS04265	COG1648	precorrin-2 dehydrogenase activity
AI20_RS04270	COG2239	Acts as a magnesium transporter
AI20_RS04280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AI20_RS04285	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AI20_RS04295	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AI20_RS04305	COG0514	ATP-dependent DNA helicase (RecQ)
AI20_RS04310	COG2050	protein possibly involved in aromatic compounds catabolism
AI20_RS04325	COG2258	MOSC domain
AI20_RS04330	COG1177	transmembrane transport
AI20_RS04335	COG1176	ABC-type spermidine putrescine transport system, permease component I
AI20_RS04340	COG3842	ATPase activity
AI20_RS04360	COG0174	glutamine synthetase
AI20_RS04380	COG3045	CreA protein
AI20_RS04385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AI20_RS04390	COG0443	Heat shock 70 kDa protein
AI20_RS04395	COG3187	Heat shock protein
AI20_RS04405	COG0366	Alpha amylase catalytic
AI20_RS04410	COG1086	Polysaccharide biosynthesis protein
AI20_RS04415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AI20_RS04420	COG2801	Transposase and inactivated derivatives
AI20_RS04425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AI20_RS04450	COG1215	transferase activity, transferring glycosyl groups
AI20_RS04465	COG0318	PFAM AMP-dependent synthetase and ligase
AI20_RS04470	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_RS04485	COG1083	cytidylyl-transferase
AI20_RS04495	COG2089	acid synthase
AI20_RS04515	COG4310	Domain of unknown function (DUF2172)
AI20_RS04550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AI20_RS04555	COG0745	RESPONSE REGULATOR receiver
AI20_RS04560	COG2205	protein histidine kinase activity
AI20_RS04570	COG0281	malic enzyme
AI20_RS04575	COG0702	epimerase
AI20_RS04580	COG0254	rRNA binding
AI20_RS04585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AI20_RS04615	COG0129	dihydroxy-acid dehydratase activity
AI20_RS04625	COG3978	acetolactate synthase activity
AI20_RS04635	COG0606	chelatase, subunit chli
AI20_RS04640	COG0204	Acyl-transferase
AI20_RS04645	COG0204	Acyl-transferase
AI20_RS04650	COG1683	Conserved Protein
AI20_RS04660	COG1335	isochorismatase
AI20_RS04670	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AI20_RS04675	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AI20_RS04680	COG3639	organic phosphonate transmembrane transporter activity
AI20_RS04685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AI20_RS04690	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AI20_RS04700	COG3084	Protein conserved in bacteria
AI20_RS04705	COG5001	Diguanylate cyclase
AI20_RS04705	COG4251	negative regulation of phosphorylation
AI20_RS04705	COG2203	Gaf domain
AI20_RS04705	COG3706	GGDEF domain
AI20_RS04710	COG0789	Transcriptional regulator
AI20_RS04720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AI20_RS04725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AI20_RS04730	COG1561	YicC-like family, N-terminal region
AI20_RS04745	COG3433	isochorismatase activity
AI20_RS04745	COG2226	methyltransferase
AI20_RS04745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AI20_RS04755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AI20_RS04770	COG1132	(ABC) transporter
AI20_RS04770	COG2375	cellular response to nickel ion
AI20_RS04775	COG1132	(ABC) transporter
AI20_RS04780	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AI20_RS04785	COG4605	iron ion homeostasis
AI20_RS04790	COG4604	ABC transporter, ATP-binding protein
AI20_RS04795	COG4607	ABC-type enterochelin transport system periplasmic component
AI20_RS04800	COG4774	siderophore transport
AI20_RS04820	COG3306	glycosyltransferase involved in LPS biosynthesis
AI20_RS04835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AI20_RS04850	COG1063	alcohol dehydrogenase
AI20_RS04855	COG3245	cytochrome
AI20_RS04860	COG3300	MHYT domain
AI20_RS04860	COG5001	Diguanylate cyclase
AI20_RS04870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AI20_RS04875	COG2166	iron-sulfur cluster assembly
AI20_RS04880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AI20_RS04920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AI20_RS04930	COG0583	DNA-binding transcription factor activity
AI20_RS04945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AI20_RS04950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AI20_RS04955	COG2223	nitrite transmembrane transporter activity
AI20_RS04960	COG3279	Response regulator of the LytR AlgR family
AI20_RS04965	COG3275	phosphorelay sensor kinase activity
AI20_RS04975	COG2205	protein histidine kinase activity
AI20_RS04975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_RS04995	COG3188	usher protein
AI20_RS05015	COG2223	nitrite transmembrane transporter activity
AI20_RS05020	COG2081	HI0933 family
AI20_RS05025	COG1528	Iron-storage protein
AI20_RS05035	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AI20_RS05040	COG0589	response to stress
AI20_RS05075	COG3642	lipopolysaccharide core region biosynthetic process
AI20_RS05080	COG0859	PFAM glycosyl transferase family 9
AI20_RS05090	COG1758	RNA polymerase activity
AI20_RS05095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AI20_RS05100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AI20_RS05110	COG2267	carboxylic ester hydrolase activity
AI20_RS05115	COG0561	phosphatase activity
AI20_RS05135	COG2271	Major facilitator Superfamily
AI20_RS05170	COG1309	transcriptional regulator
AI20_RS05175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_RS05180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_RS05185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_RS05185	COG4191	Histidine kinase
AI20_RS05190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AI20_RS05215	COG2205	protein histidine kinase activity
AI20_RS05220	COG0745	RESPONSE REGULATOR receiver
AI20_RS05225	COG2814	Major facilitator Superfamily
AI20_RS05235	COG3977	Valine--pyruvate aminotransferase
AI20_RS05240	COG0071	Belongs to the small heat shock protein (HSP20) family
AI20_RS05245	COG0071	Belongs to the small heat shock protein (HSP20) family
AI20_RS05250	COG2378	regulation of single-species biofilm formation
AI20_RS05270	COG0592	DNA-directed DNA polymerase activity
AI20_RS05275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AI20_RS05290	COG1126	abc transporter atp-binding protein
AI20_RS05295	COG0594	ribonuclease P activity
AI20_RS05300	COG0706	membrane insertase activity
AI20_RS05305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AI20_RS05320	COG1120	ATPase activity
AI20_RS05325	COG4615	Cyclic peptide transporter
AI20_RS05330	COG4774	siderophore transport
AI20_RS05335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AI20_RS05340	COG0445	tRNA wobble uridine modification
AI20_RS05345	COG0357	Ribosomal RNA small subunit methyltransferase G
AI20_RS05350	COG1192	Involved in chromosome partitioning
AI20_RS05355	COG1475	DNA binding
AI20_RS05365	COG0356	it plays a direct role in the translocation of protons across the membrane
AI20_RS05375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AI20_RS05380	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AI20_RS05385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AI20_RS05390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AI20_RS05395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AI20_RS05400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AI20_RS05405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AI20_RS05410	COG4452	Inner membrane protein CreD
AI20_RS05420	COG2205	protein histidine kinase activity
AI20_RS05425	COG0745	RESPONSE REGULATOR receiver
AI20_RS05430	COG1349	DNA-binding transcription factor activity
AI20_RS05435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AI20_RS05440	COG2771	luxR family
AI20_RS05450	COG0811	peptide transport
AI20_RS05455	COG0811	peptide transport
AI20_RS05460	COG0848	biopolymer transport protein
AI20_RS05465	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AI20_RS05505	COG0402	S-adenosylhomocysteine deaminase activity
AI20_RS05510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AI20_RS05520	COG3165	ubiquinone biosynthetic process from chorismate
AI20_RS05525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AI20_RS05535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AI20_RS05540	COG0805	protein transport
AI20_RS05545	COG0084	hydrolase, TatD family'
AI20_RS05570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_RS05575	COG0742	ribosomal rna small subunit methyltransferase
AI20_RS05590	COG0248	Ppx GppA phosphatase
AI20_RS05595	COG0513	Belongs to the DEAD box helicase family
AI20_RS05600	COG3118	belongs to the thioredoxin family
AI20_RS05615	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AI20_RS05640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AI20_RS05680	COG1609	Transcriptional regulator
AI20_RS05695	COG2188	Transcriptional regulator
AI20_RS05700	COG3604	Transcriptional regulator
AI20_RS05705	COG0426	domain, Protein
AI20_RS05705	COG1773	rubredoxin
AI20_RS05710	COG0446	pyridine nucleotide-disulphide oxidoreductase
AI20_RS05720	COG0348	domain, Protein
AI20_RS05725	COG0814	amino acid
AI20_RS05755	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AI20_RS05760	COG0751	glycine-tRNA ligase activity
AI20_RS05765	COG0752	glycyl-tRNA synthetase alpha subunit
AI20_RS05770	COG2818	Glycosylase
AI20_RS05775	COG1335	isochorismatase
AI20_RS05780	COG2885	chlorophyll binding
AI20_RS05790	COG0251	oxidation-reduction process
AI20_RS05795	COG0425	Belongs to the sulfur carrier protein TusA family
AI20_RS05820	COG0183	Belongs to the thiolase family
AI20_RS05825	COG1250	3-hydroxyacyl-CoA dehydrogenase
AI20_RS05825	COG1024	Enoyl-CoA hydratase
AI20_RS05830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AI20_RS05835	COG0006	proline dipeptidase activity
AI20_RS05840	COG1739	Uncharacterized protein family UPF0029
AI20_RS05845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AI20_RS05850	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AI20_RS05875	COG0045	succinate-CoA ligase (ADP-forming) activity
AI20_RS05875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AI20_RS05875	COG1042	CoA-binding domain protein
AI20_RS05890	COG0583	DNA-binding transcription factor activity
AI20_RS05895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AI20_RS05900	COG0166	Belongs to the GPI family
AI20_RS05910	COG0668	transmembrane transport
AI20_RS05915	COG1309	transcriptional regulator
AI20_RS05920	COG0756	dUTP diphosphatase activity
AI20_RS05925	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AI20_RS05930	COG2003	Belongs to the UPF0758 family
AI20_RS05935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AI20_RS05945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AI20_RS05950	COG2990	Protein conserved in bacteria
AI20_RS05955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AI20_RS05960	COG0859	PFAM glycosyl transferase family 9
AI20_RS05965	COG0463	Glycosyl transferase, family 2
AI20_RS05970	COG0859	PFAM glycosyl transferase family 9
AI20_RS05975	COG1519	Transferase
AI20_RS05995	COG1609	Transcriptional regulator
AI20_RS06000	COG0604	alcohol dehydrogenase
AI20_RS06010	COG1580	Controls the rotational direction of flagella during chemotaxis
AI20_RS06015	COG3161	chorismate lyase activity
AI20_RS06020	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AI20_RS06025	COG2937	Belongs to the GPAT DAPAT family
AI20_RS06030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AI20_RS06050	COG0534	Mate efflux family protein
AI20_RS06055	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AI20_RS06060	COG2205	protein histidine kinase activity
AI20_RS06065	COG0745	RESPONSE REGULATOR receiver
AI20_RS06075	COG1045	serine acetyltransferase
AI20_RS06085	COG3074	FtsZ-dependent cytokinesis
AI20_RS06090	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AI20_RS06095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AI20_RS06095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AI20_RS06100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AI20_RS06140	COG1609	Transcriptional regulator
AI20_RS06145	COG3250	beta-galactosidase activity
AI20_RS06150	COG2731	YhcH YjgK YiaL family protein
AI20_RS06155	COG0531	amino acid
AI20_RS06160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AI20_RS06165	COG0531	amino acid
AI20_RS06170	COG0385	Bile acid
AI20_RS06175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AI20_RS06195	COG0583	DNA-binding transcription factor activity
AI20_RS06200	COG1079	Belongs to the binding-protein-dependent transport system permease family
AI20_RS06205	COG4603	Belongs to the binding-protein-dependent transport system permease family
AI20_RS06210	COG3845	ABC transporter
AI20_RS06215	COG1744	ABC transporter substrate-binding protein PnrA-like
AI20_RS06220	COG0210	DNA helicase
AI20_RS06230	COG1943	Transposase
AI20_RS06250	COG0583	DNA-binding transcription factor activity
AI20_RS06280	COG3161	chorismate lyase activity
AI20_RS06315	COG1280	lysine exporter protein (LysE YggA)
AI20_RS06325	COG2391	methyltransferase activity
AI20_RS06335	COG1280	lysine exporter protein (LysE YggA)
AI20_RS06345	COG2962	Rard protein
AI20_RS06355	COG1012	belongs to the aldehyde dehydrogenase family
AI20_RS06360	COG1396	sequence-specific DNA binding
AI20_RS06365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AI20_RS06375	COG0519	Catalyzes the synthesis of GMP from XMP
AI20_RS06375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AI20_RS06380	COG0686	Belongs to the AlaDH PNT family
AI20_RS06385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AI20_RS06405	COG1322	Protein conserved in bacteria
AI20_RS06410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AI20_RS06415	COG0569	domain protein
AI20_RS06420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AI20_RS06420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AI20_RS06425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AI20_RS06430	COG0242	peptide deformylase activity
AI20_RS06440	COG0758	DNA mediated transformation
AI20_RS06445	COG2922	Belongs to the Smg family
AI20_RS06450	COG0551	DNA topoisomerase type I activity
AI20_RS06460	COG0009	L-threonylcarbamoyladenylate synthase
AI20_RS06470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AI20_RS06480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AI20_RS06490	COG3078	GTPase activator activity
AI20_RS06505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AI20_RS06510	COG2204	response regulator
AI20_RS06515	COG3852	Histidine kinase
AI20_RS06525	COG0174	glutamine synthetase
AI20_RS06530	COG1217	gtp-binding protein TYPA
AI20_RS06535	COG1295	ribonuclease BN
AI20_RS06540	COG1490	D-aminoacyl-tRNA deacylase activity
AI20_RS06560	COG0456	acetyltransferase
AI20_RS06570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AI20_RS06575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AI20_RS06580	COG2610	gluconate transmembrane transporter activity
AI20_RS06585	COG3265	gluconokinase activity
AI20_RS06590	COG0129	dihydroxy-acid dehydratase activity
AI20_RS06595	COG0800	Aldolase
AI20_RS06600	COG1609	Transcriptional regulator
AI20_RS06610	COG4942	peptidase
AI20_RS06615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AI20_RS06620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AI20_RS06625	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AI20_RS06630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AI20_RS06635	COG0316	Belongs to the HesB IscA family
AI20_RS06635	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AI20_RS06640	COG1040	competence protein
AI20_RS06645	COG0596	Alpha beta hydrolase
AI20_RS06665	COG2183	response to ionizing radiation
AI20_RS06670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AI20_RS06690	COG0051	transcription antitermination factor activity, RNA binding
AI20_RS06695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AI20_RS06700	COG0088	Forms part of the polypeptide exit tunnel
AI20_RS06705	COG0089	rRNA binding
AI20_RS06710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AI20_RS06715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AI20_RS06720	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AI20_RS06725	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AI20_RS06730	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AI20_RS06735	COG0255	Belongs to the universal ribosomal protein uL29 family
AI20_RS06740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AI20_RS06745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AI20_RS06750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AI20_RS06755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AI20_RS06760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AI20_RS06765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AI20_RS06770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AI20_RS06775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AI20_RS06780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AI20_RS06785	COG0200	Binds to the 23S rRNA
AI20_RS06790	COG0201	protein transport
AI20_RS06795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AI20_RS06800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AI20_RS06805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AI20_RS06860	COG2249	NAD(P)H dehydrogenase (quinone) activity
AI20_RS06865	COG0583	DNA-binding transcription factor activity
AI20_RS06870	COG4221	oxidoreductase activity
AI20_RS06885	COG1770	oligopeptidase
AI20_RS06890	COG2358	TRAP transporter, solute receptor (TAXI family
AI20_RS06900	COG3714	YhhN family
AI20_RS06925	COG1301	dicarboxylic acid transport
AI20_RS06935	COG2095	MarC family integral membrane protein
AI20_RS06945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AI20_RS06955	COG0741	lytic transglycosylase activity
AI20_RS06960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AI20_RS06985	COG0742	ribosomal rna small subunit methyltransferase
AI20_RS06990	COG0552	protein localization to endoplasmic reticulum
AI20_RS06995	COG2884	Cell division ATP-binding protein ftsE
AI20_RS07000	COG2177	Part of the ABC transporter FtsEX involved in
AI20_RS07010	COG0288	reversible hydration of carbon dioxide
AI20_RS07015	COG2188	Transcriptional regulator
AI20_RS07020	COG1228	amidohydrolase
AI20_RS07025	COG0010	Belongs to the arginase family
AI20_RS07030	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AI20_RS07035	COG2986	histidine ammonia-lyase
AI20_RS07040	COG0387	Pfam Sodium calcium exchanger
AI20_RS07045	COG2200	EAL domain
AI20_RS07050	COG2200	EAL domain
AI20_RS07050	COG2199	diguanylate cyclase activity
AI20_RS07095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AI20_RS07100	COG1459	type II secretion system
AI20_RS07110	COG2165	general secretion pathway protein
AI20_RS07115	COG4969	Belongs to the N-Me-Phe pilin family
AI20_RS07145	COG1077	Cell shape determining protein MreB Mrl
AI20_RS07150	COG1792	Involved in formation and maintenance of cell shape
AI20_RS07155	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AI20_RS07160	COG0424	maF-like protein
AI20_RS07165	COG1530	ribonuclease E activity
AI20_RS07170	COG3164	Protein of unknown function
AI20_RS07185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AI20_RS07190	COG0312	modulator of DNA gyrase
AI20_RS07205	COG0477	Major facilitator Superfamily
AI20_RS07215	COG3437	response regulator, receiver
AI20_RS07220	COG5002	protein histidine kinase activity
AI20_RS07220	COG0784	Response regulator, receiver
AI20_RS07220	COG2205	protein histidine kinase activity
AI20_RS07230	COG1366	Belongs to the anti-sigma-factor antagonist family
AI20_RS07250	COG3700	Belongs to the class B bacterial acid phosphatase family
AI20_RS07255	COG2321	neutral zinc metallopeptidase
AI20_RS07265	COG1639	'signal transduction protein
AI20_RS07300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AI20_RS07310	COG1715	Restriction endonuclease
AI20_RS07330	COG0582	viral genome integration into host DNA
AI20_RS07345	COG0189	ligase activity
AI20_RS07350	COG0642	Histidine kinase
AI20_RS07355	COG0745	RESPONSE REGULATOR receiver
AI20_RS07380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AI20_RS07385	COG0352	thiamine-phosphate diphosphorylase activity
AI20_RS07390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AI20_RS07400	COG2022	thiamine diphosphate biosynthetic process
AI20_RS07405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AI20_RS07415	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
AI20_RS07435	COG0814	amino acid
AI20_RS07440	COG3932	Exopolysaccharide synthesis, ExoD
AI20_RS07460	COG1733	regulation of RNA biosynthetic process
AI20_RS07465	COG0456	acetyltransferase
AI20_RS07500	COG1494	fructose-1,6-bisphosphatase
AI20_RS07515	COG2959	enzyme of heme biosynthesis
AI20_RS07525	COG0181	hydroxymethylbilane synthase activity
AI20_RS07530	COG3072	Adenylate cyclase
AI20_RS07535	COG0400	carboxylic ester hydrolase activity
AI20_RS07540	COG1965	Belongs to the frataxin family
AI20_RS07545	COG0019	diaminopimelate decarboxylase activity
AI20_RS07550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AI20_RS07565	COG1011	Hydrolase
AI20_RS07585	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AI20_RS07590	COG0561	phosphatase activity
AI20_RS07605	COG1129	ABC transporter
AI20_RS07605	COG0842	Transport permease protein
AI20_RS07615	COG1058	Belongs to the CinA family
AI20_RS07615	COG1546	Belongs to the CinA family
AI20_RS07620	COG1418	mRNA catabolic process
AI20_RS07625	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AI20_RS07635	COG1522	sequence-specific DNA binding
AI20_RS07640	COG1368	sulfuric ester hydrolase activity
AI20_RS07660	COG1285	pathogenesis
AI20_RS07680	COG4221	oxidoreductase activity
AI20_RS07695	COG1979	alcohol dehydrogenase
AI20_RS07705	COG2873	o-acetylhomoserine
AI20_RS07710	COG4533	DNA binding
AI20_RS07725	COG5380	lipid catabolic process
AI20_RS07730	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AI20_RS07740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AI20_RS07745	COG2949	membrane
AI20_RS07750	COG3291	Pkd domain containing protein
AI20_RS07760	COG3539	Fimbrial protein
AI20_RS07770	COG3188	usher protein
AI20_RS07775	COG3121	Chaperone
AI20_RS07780	COG3539	Fimbrial protein
AI20_RS07795	COG0318	PFAM AMP-dependent synthetase and ligase
AI20_RS07800	COG1441	menaquinone biosynthetic process
AI20_RS07805	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AI20_RS07810	COG0596	Alpha beta hydrolase
AI20_RS07815	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AI20_RS07820	COG1169	isochorismate synthase
AI20_RS07825	COG1575	Belongs to the MenA family. Type 1 subfamily
AI20_RS07850	COG0513	Belongs to the DEAD box helicase family
AI20_RS07855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AI20_RS07860	COG1988	membrane-bound metal-dependent
AI20_RS07875	COG1671	Belongs to the UPF0178 family
AI20_RS07900	COG3263	regulation of cellular component size
AI20_RS07905	COG3722	fumarate hydratase activity
AI20_RS07910	COG0246	Mannitol dehydrogenase
AI20_RS07915	COG2213	PTS system mannitol-specific
AI20_RS07915	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_RS07925	COG1309	transcriptional regulator
AI20_RS07930	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AI20_RS07940	COG3916	Acyl-homoserine-lactone synthase
AI20_RS07945	COG2771	luxR family
AI20_RS07960	COG3133	Outer membrane lipoprotein
AI20_RS07965	COG0456	acetyltransferase
AI20_RS07985	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AI20_RS07990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AI20_RS08000	COG3031	protein transport across the cell outer membrane
AI20_RS08010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AI20_RS08015	COG1459	type II secretion system
AI20_RS08020	COG2165	general secretion pathway protein
AI20_RS08030	COG2165	general secretion pathway protein
AI20_RS08035	COG4795	General secretion pathway protein
AI20_RS08040	COG3156	type II secretion system protein K
AI20_RS08050	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AI20_RS08065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AI20_RS08080	COG1011	Hydrolase
AI20_RS08085	COG0494	nUDIX hydrolase
AI20_RS08090	COG1218	3'(2'),5'-bisphosphate nucleotidase
AI20_RS08095	COG0814	amino acid
AI20_RS08100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AI20_RS08105	COG3708	Transcriptional regulator
AI20_RS08105	COG2207	Transcriptional regulator
AI20_RS08115	COG0626	cystathionine gamma-synthase activity
AI20_RS08120	COG0527	aspartate kinase activity
AI20_RS08120	COG0460	homoserine dehydrogenase
AI20_RS08130	COG1280	lysine exporter protein (LysE YggA)
AI20_RS08150	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AI20_RS08160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AI20_RS08165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AI20_RS08175	COG0137	argininosuccinate synthase activity
AI20_RS08180	COG0165	Argininosuccinate lyase
AI20_RS08205	COG0110	maltose O-acetyltransferase activity
AI20_RS08210	COG3174	membrane
AI20_RS08215	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AI20_RS08225	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AI20_RS08230	COG4208	sulfate ABC transporter
AI20_RS08235	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AI20_RS08240	COG0583	DNA-binding transcription factor activity
AI20_RS08245	COG3397	chitin binding
AI20_RS08280	COG0793	Belongs to the peptidase S41A family
AI20_RS08280	COG4946	Tricorn protease homolog
AI20_RS08300	COG1328	CTP reductase activity
AI20_RS08305	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AI20_RS08320	COG1448	Aminotransferase
AI20_RS08360	COG0513	Belongs to the DEAD box helicase family
AI20_RS08390	COG3112	Uncharacterised protein family (UPF0231)
AI20_RS08395	COG3835	regulator
AI20_RS08400	COG2610	gluconate transmembrane transporter activity
AI20_RS08405	COG1929	Belongs to the glycerate kinase type-1 family
AI20_RS08420	COG0583	DNA-binding transcription factor activity
AI20_RS08425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AI20_RS08440	COG0347	Belongs to the P(II) protein family
AI20_RS08445	COG1840	ABC-type Fe3 transport system, periplasmic component
AI20_RS08455	COG3842	ATPase activity
AI20_RS08460	COG2837	iron assimilation
AI20_RS08465	COG1438	arginine binding
AI20_RS08470	COG1126	abc transporter atp-binding protein
AI20_RS08475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_RS08480	COG4215	(ABC) transporter
AI20_RS08485	COG4160	amino acid transport
AI20_RS08490	COG0039	L-malate dehydrogenase activity
AI20_RS08495	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AI20_RS08500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AI20_RS08500	COG1017	nitric oxide dioxygenase activity
AI20_RS08505	COG1959	2 iron, 2 sulfur cluster binding
AI20_RS08510	COG4536	flavin adenine dinucleotide binding
AI20_RS08515	COG4137	Cytochrome C assembly protein
AI20_RS08520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AI20_RS08525	COG0228	four-way junction DNA binding
AI20_RS08530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AI20_RS08535	COG0336	Belongs to the RNA methyltransferase TrmD family
AI20_RS08540	COG0335	large ribosomal subunit rRNA binding
AI20_RS08550	COG3066	DNA modification
AI20_RS08555	COG1051	belongs to the nudix hydrolase family
AI20_RS08565	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AI20_RS08570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AI20_RS08575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AI20_RS08585	COG0583	DNA-binding transcription factor activity
AI20_RS08590	COG0640	Transcriptional regulator
AI20_RS08595	COG0268	Binds directly to 16S ribosomal RNA
AI20_RS08600	COG0728	peptidoglycan biosynthetic process
AI20_RS08605	COG0196	riboflavin kinase activity
AI20_RS08610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AI20_RS08615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AI20_RS08620	COG1047	Peptidyl-prolyl cis-trans
AI20_RS08625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AI20_RS08685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AI20_RS08685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AI20_RS08700	COG1854	S-ribosylhomocysteine lyase activity
AI20_RS08705	COG3706	GGDEF domain
AI20_RS08710	COG0557	exoribonuclease II activity
AI20_RS08725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AI20_RS08735	COG2153	protein acetylation
AI20_RS08740	COG0697	spore germination
AI20_RS08760	COG2814	Major facilitator Superfamily
AI20_RS08765	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_RS08770	COG0583	DNA-binding transcription factor activity
AI20_RS08780	COG1914	H( )-stimulated, divalent metal cation uptake system
AI20_RS08785	COG0360	Binds together with S18 to 16S ribosomal RNA
AI20_RS08790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AI20_RS08795	COG0359	binds to the 23S rRNA
AI20_RS08800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AI20_RS08830	COG1238	metal cluster binding
AI20_RS08835	COG0612	Peptidase, M16
AI20_RS08840	COG2918	glutathione biosynthetic process
AI20_RS08845	COG1022	Amp-dependent synthetase and ligase
AI20_RS08855	COG0456	acetyltransferase
AI20_RS08865	COG0714	Associated with various cellular activities
AI20_RS08885	COG5001	Diguanylate cyclase
AI20_RS08910	COG1902	pentaerythritol trinitrate reductase activity
AI20_RS08920	COG2852	Protein conserved in bacteria
AI20_RS08930	COG2957	Belongs to the agmatine deiminase family
AI20_RS08955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AI20_RS08960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AI20_RS08970	COG0513	Belongs to the DEAD box helicase family
AI20_RS08990	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AI20_RS09015	COG2070	2-Nitropropane dioxygenase
AI20_RS09055	COG2205	protein histidine kinase activity
AI20_RS09060	COG0745	RESPONSE REGULATOR receiver
AI20_RS09065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_RS09070	COG0577	efflux transmembrane transporter activity
AI20_RS09070	COG1136	(ABC) transporter
AI20_RS09075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_RS09080	COG1126	abc transporter atp-binding protein
AI20_RS09085	COG0765	amino acid transport
AI20_RS09090	COG0765	amino acid transport
AI20_RS09095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AI20_RS09100	COG1505	serine-type exopeptidase activity
AI20_RS09105	COG2982	Protein involved in outer membrane biogenesis
AI20_RS09120	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AI20_RS09135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AI20_RS09140	COG4991	sh3 domain protein
AI20_RS09150	COG2816	NAD+ diphosphatase activity
AI20_RS09155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AI20_RS09160	COG1940	carbohydrate kinase activity
AI20_RS09165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AI20_RS09170	COG0126	phosphoglycerate kinase activity
AI20_RS09180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AI20_RS09230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AI20_RS09240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AI20_RS09245	COG1595	DNA-templated transcription, initiation
AI20_RS09250	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AI20_RS09265	COG0481	GTPase activity
AI20_RS09270	COG0681	Belongs to the peptidase S26 family
AI20_RS09275	COG0571	ribonuclease III activity
AI20_RS09285	COG1381	Involved in DNA repair and RecF pathway recombination
AI20_RS09290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AI20_RS09300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AI20_RS09305	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_RS09310	COG3716	PTS system mannose fructose sorbose family IID component
AI20_RS09320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AI20_RS09325	COG2222	sugar isomerase
AI20_RS09335	COG1349	DNA-binding transcription factor activity
AI20_RS09340	COG3023	N-Acetylmuramoyl-L-alanine amidase
AI20_RS09345	COG4807	Protein conserved in bacteria
AI20_RS09355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AI20_RS09360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AI20_RS09365	COG3956	TIGRFAM MazG family protein
AI20_RS09370	COG0504	CTP synthase activity
AI20_RS09375	COG0148	phosphopyruvate hydratase activity
AI20_RS09380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AI20_RS09385	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AI20_RS09395	COG0585	pseudouridine synthase activity
AI20_RS09400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AI20_RS09405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AI20_RS09410	COG1238	metal cluster binding
AI20_RS09425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AI20_RS09430	COG1610	YqeY-like protein
AI20_RS09435	COG0358	DNA primase activity
AI20_RS09440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AI20_RS09465	COG0138	bifunctional purine biosynthesis protein purh
AI20_RS09480	COG3036	rescue of stalled ribosome
AI20_RS09485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AI20_RS09490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AI20_RS09500	COG0673	inositol 2-dehydrogenase activity
AI20_RS09510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AI20_RS09515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AI20_RS09520	COG3227	Zinc metalloprotease (Elastase)
AI20_RS09530	COG0477	Major facilitator Superfamily
AI20_RS09540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AI20_RS09545	COG1027	Aspartate ammonia-lyase
AI20_RS09550	COG3030	protein affecting phage T7 exclusion by the F plasmid
AI20_RS09555	COG0534	Mate efflux family protein
AI20_RS09560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AI20_RS09565	COG0459	protein refolding
AI20_RS09575	COG3300	MHYT domain
AI20_RS09575	COG5001	Diguanylate cyclase
AI20_RS09580	COG0564	pseudouridine synthase activity
AI20_RS09585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AI20_RS09620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AI20_RS09630	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AI20_RS09635	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AI20_RS09645	COG4143	(ABC) transporter
AI20_RS09660	COG0066	3-isopropylmalate dehydratase activity
AI20_RS09665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AI20_RS09670	COG0473	3-isopropylmalate dehydrogenase activity
AI20_RS09675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AI20_RS09685	COG0671	phosphoesterase, PA-phosphatase related
AI20_RS09695	COG0028	Belongs to the TPP enzyme family
AI20_RS09700	COG0440	acetolactate synthase activity
AI20_RS09705	COG0857	belongs to the CobB CobQ family
AI20_RS09705	COG0280	phosphate acetyltransferase
AI20_RS09710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AI20_RS09720	COG3013	Belongs to the UPF0304 family
AI20_RS09725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AI20_RS09730	COG2716	regulation of RNA biosynthetic process
AI20_RS09740	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AI20_RS09745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AI20_RS09760	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AI20_RS09780	COG5002	protein histidine kinase activity
AI20_RS09780	COG2198	Histidine kinase
AI20_RS09780	COG0784	Response regulator, receiver
AI20_RS09805	COG0840	transmembrane signaling receptor activity
AI20_RS09815	COG1464	Belongs to the NlpA lipoprotein family
AI20_RS09820	COG2011	ABC-type metal ion transport system permease component
AI20_RS09825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AI20_RS09845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AI20_RS09845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AI20_RS09850	COG0802	atpase or kinase
AI20_RS09860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AI20_RS09865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AI20_RS09870	COG1923	regulation of RNA biosynthetic process
AI20_RS09875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AI20_RS09880	COG0330	HflC and HflK could
AI20_RS09885	COG0330	HflC and HflK could
AI20_RS09890	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AI20_RS09895	COG0142	geranyltranstransferase activity
AI20_RS09905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AI20_RS09910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AI20_RS09915	COG3314	Sporulation integral membrane protein YlbJ
AI20_RS09920	COG0318	PFAM AMP-dependent synthetase and ligase
AI20_RS09935	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AI20_RS09940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AI20_RS09950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AI20_RS09955	COG2967	ApaG domain
AI20_RS09960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AI20_RS09965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AI20_RS09975	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AI20_RS09980	COG3178	'Phosphotransferase
AI20_RS09985	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AI20_RS09990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AI20_RS09995	COG2252	PERMEase
AI20_RS10005	COG0488	(ABC) transporter
AI20_RS10020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AI20_RS10025	COG0741	lytic transglycosylase activity
AI20_RS10050	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AI20_RS10055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AI20_RS10065	COG3721	Heme iron utilization protein
AI20_RS10070	COG0748	coenzyme F420 binding
AI20_RS10090	COG4771	TonB-dependent receptor
AI20_RS10095	COG2814	Major facilitator Superfamily
AI20_RS10105	COG3655	Transcriptional regulator
AI20_RS10115	COG2205	protein histidine kinase activity
AI20_RS10115	COG2202	Pas domain
AI20_RS10130	COG3397	chitin binding
AI20_RS10145	COG1765	OsmC-like protein
AI20_RS10160	COG3954	Phosphoribulokinase
AI20_RS10165	COG2076	Multidrug Resistance protein
AI20_RS10170	COG2076	Multidrug Resistance protein
AI20_RS10175	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AI20_RS10180	COG0726	polysaccharide deacetylase
AI20_RS10185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AI20_RS10185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AI20_RS10190	COG0463	Glycosyl transferase, family 2
AI20_RS10195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AI20_RS10205	COG3089	Belongs to the UPF0270 family
AI20_RS10210	COG0429	hydrolase of the alpha beta-hydrolase fold
AI20_RS10215	COG0835	chemotaxis
AI20_RS10215	COG0784	Response regulator, receiver
AI20_RS10225	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AI20_RS10230	COG1047	Peptidyl-prolyl cis-trans
AI20_RS10235	COG2900	Belongs to the SlyX family
AI20_RS10245	COG0545	Peptidyl-prolyl cis-trans isomerase
AI20_RS10250	COG2204	response regulator
AI20_RS10270	COG0737	Belongs to the 5'-nucleotidase family
AI20_RS10275	COG2200	EAL domain
AI20_RS10290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AI20_RS10295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_RS10300	COG0826	peptidase U32
AI20_RS10330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AI20_RS10335	COG2201	protein-glutamate methylesterase activity
AI20_RS10340	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AI20_RS10350	COG0840	transmembrane signaling receptor activity
AI20_RS10355	COG0835	chemotaxis
AI20_RS10365	COG2198	Histidine kinase
AI20_RS10365	COG0643	Histidine kinase
AI20_RS10375	COG0745	RESPONSE REGULATOR receiver
AI20_RS10385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AI20_RS10395	COG1280	lysine exporter protein (LysE YggA)
AI20_RS10400	COG0826	peptidase U32
AI20_RS10430	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AI20_RS10450	COG0300	oxidoreductase activity
AI20_RS10460	COG0840	transmembrane signaling receptor activity
AI20_RS10470	COG2610	gluconate transmembrane transporter activity
AI20_RS10475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AI20_RS10480	COG3622	Belongs to the hyi family
AI20_RS10485	COG0235	Class ii aldolase
AI20_RS10495	COG2084	Dehydrogenase
AI20_RS10500	COG1349	DNA-binding transcription factor activity
AI20_RS10530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AI20_RS10570	COG2003	Belongs to the UPF0758 family
AI20_RS10615	COG5377	YqaJ viral recombinase family
AI20_RS10695	COG0077	Prephenate dehydratase
AI20_RS10695	COG1605	Chorismate mutase
AI20_RS10725	COG3272	Protein of unknown function (DUF1722)
AI20_RS10730	COG0789	Transcriptional regulator
AI20_RS10735	COG0415	Belongs to the DNA photolyase family
AI20_RS10745	COG0300	oxidoreductase activity
AI20_RS10760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AI20_RS10785	COG0783	Belongs to the Dps family
AI20_RS10790	COG1151	hydroxylamine reductase activity
AI20_RS10800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AI20_RS10805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AI20_RS10805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AI20_RS10820	COG2771	luxR family
AI20_RS10875	COG0693	protein deglycase activity
AI20_RS10880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AI20_RS10885	COG1666	GTP binding
AI20_RS10890	COG3248	Nucleoside-binding outer membrane protein
AI20_RS10895	COG2211	Major facilitator Superfamily
AI20_RS10905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AI20_RS10915	COG2813	Specifically methylates the guanine in position
AI20_RS10920	COG0271	Belongs to the BolA IbaG family
AI20_RS10925	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AI20_RS10930	COG1805	sodium ion transport
AI20_RS10935	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AI20_RS10940	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AI20_RS10945	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AI20_RS10950	COG2871	sodium ion transport
AI20_RS10955	COG1477	protein flavinylation
AI20_RS10970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AI20_RS10975	COG0840	transmembrane signaling receptor activity
AI20_RS10980	COG0583	DNA-binding transcription factor activity
AI20_RS10990	COG2363	Small membrane protein
AI20_RS10995	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AI20_RS11005	COG0473	3-isopropylmalate dehydrogenase activity
AI20_RS11010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AI20_RS11015	COG1611	Belongs to the LOG family
AI20_RS11030	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AI20_RS11030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AI20_RS11040	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AI20_RS11065	COG3098	single-species biofilm formation
AI20_RS11070	COG0564	pseudouridine synthase activity
AI20_RS11100	COG2171	N-acyltransferase activity
AI20_RS11105	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AI20_RS11110	COG0024	Methionine aminopeptidase
AI20_RS11115	COG0052	Belongs to the universal ribosomal protein uS2 family
AI20_RS11120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AI20_RS11125	COG0528	UMP kinase activity
AI20_RS11130	COG0233	cytoplasmic translational termination
AI20_RS11135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AI20_RS11140	COG0575	Belongs to the CDS family
AI20_RS11145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AI20_RS11150	COG0750	zinc metalloprotease
AI20_RS11165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AI20_RS11170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AI20_RS11175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AI20_RS11180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AI20_RS11185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AI20_RS11195	COG0825	malonyl-CoA metabolic process
AI20_RS11200	COG3710	Transcriptional regulator
AI20_RS11205	COG0531	amino acid
AI20_RS11210	COG1982	Orn Lys Arg decarboxylase major
AI20_RS11215	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AI20_RS11230	COG0814	amino acid
AI20_RS11235	COG0531	amino acid
AI20_RS11245	COG0488	(ABC) transporter
AI20_RS11255	COG3590	peptidase
AI20_RS11260	COG0037	tRNA processing
AI20_RS11265	COG3706	GGDEF domain
AI20_RS11300	COG0366	Alpha amylase catalytic
AI20_RS11315	COG0463	Glycosyl transferase, family 2
AI20_RS11330	COG2989	Protein conserved in bacteria
AI20_RS11335	COG3108	Peptidase M15
AI20_RS11345	COG2860	membrane
AI20_RS11355	COG1196	nuclear chromosome segregation
AI20_RS11360	COG3115	cell septum assembly
AI20_RS11365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AI20_RS11375	COG1328	CTP reductase activity
AI20_RS11380	COG0602	queuosine metabolic process
AI20_RS11405	COG1566	PFAM secretion protein HlyD family protein
AI20_RS11410	COG1846	Transcriptional regulator
AI20_RS11420	COG0281	malic enzyme
AI20_RS11425	COG3290	protein histidine kinase activity
AI20_RS11430	COG4565	transcriptional regulatory protein
AI20_RS11435	COG0697	spore germination
AI20_RS11450	COG3284	Transcriptional regulator
AI20_RS11455	COG1960	acyl-CoA dehydrogenase activity
AI20_RS11460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AI20_RS11465	COG0346	lactoylglutathione lyase activity
AI20_RS11470	COG0745	RESPONSE REGULATOR receiver
AI20_RS11475	COG5002	protein histidine kinase activity
AI20_RS11510	COG0545	Peptidyl-prolyl cis-trans isomerase
AI20_RS11515	COG1131	(ABC) transporter
AI20_RS11530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_RS11535	COG4597	amino acid ABC transporter
AI20_RS11540	COG0765	amino acid transport
AI20_RS11545	COG1126	abc transporter atp-binding protein
AI20_RS11555	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AI20_RS11575	COG0019	diaminopimelate decarboxylase activity
AI20_RS11580	COG1115	amino acid carrier protein
AI20_RS11585	COG0095	Lipoate-protein ligase
AI20_RS11590	COG2233	PERMEase
AI20_RS11605	COG0534	Mate efflux family protein
AI20_RS11610	COG2207	Transcriptional regulator
AI20_RS11615	COG0281	malic enzyme
AI20_RS11645	COG0733	neurotransmitter:sodium symporter activity
AI20_RS11650	COG1752	Esterase of the alpha-beta hydrolase superfamily
AI20_RS11660	COG1566	PFAM secretion protein HlyD family protein
AI20_RS11665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_RS11675	COG1032	radical SAM domain protein
AI20_RS11685	COG1280	lysine exporter protein (LysE YggA)
AI20_RS11690	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_RS11710	COG1032	radical SAM domain protein
AI20_RS11745	COG0673	inositol 2-dehydrogenase activity
AI20_RS11750	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AI20_RS11755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AI20_RS11765	COG0366	Alpha amylase catalytic
AI20_RS11790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AI20_RS11800	COG0788	formyltetrahydrofolate deformylase activity
AI20_RS11810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AI20_RS11820	COG3118	belongs to the thioredoxin family
AI20_RS11830	COG0791	NLP P60 protein
AI20_RS11835	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AI20_RS11850	COG1376	ErfK ybiS ycfS ynhG family protein
AI20_RS11850	COG1388	LysM domain
AI20_RS11875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_RS11880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_RS11885	COG0745	RESPONSE REGULATOR receiver
AI20_RS11890	COG5002	protein histidine kinase activity
AI20_RS11910	COG4869	propanediol catabolic process
AI20_RS11920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AI20_RS11925	COG1882	Formate acetyltransferase
AI20_RS11930	COG1012	belongs to the aldehyde dehydrogenase family
AI20_RS11930	COG1454	alcohol dehydrogenase
AI20_RS11940	COG1012	belongs to the aldehyde dehydrogenase family
AI20_RS11940	COG1454	alcohol dehydrogenase
AI20_RS11975	COG0583	DNA-binding transcription factor activity
AI20_RS11980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AI20_RS11985	COG0243	molybdopterin cofactor binding
AI20_RS11995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AI20_RS12005	COG1960	acyl-CoA dehydrogenase activity
AI20_RS12010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_RS12020	COG0469	pyruvate kinase activity
AI20_RS12025	COG1737	Transcriptional regulator
AI20_RS12045	COG2274	protein secretion by the type I secretion system
AI20_RS12055	COG2274	protein secretion by the type I secretion system
AI20_RS12070	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AI20_RS12070	COG3064	Membrane
AI20_RS12070	COG1073	alpha beta
AI20_RS12075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AI20_RS12090	COG1342	Belongs to the UPF0251 family
AI20_RS12095	COG0640	Transcriptional regulator
AI20_RS12110	COG0798	PFAM Bile acid sodium symporter
AI20_RS12115	COG1393	Belongs to the ArsC family
AI20_RS12130	COG1677	Flagellar hook-basal body complex protein FliE
AI20_RS12140	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AI20_RS12195	COG1684	flagellar biosynthetic protein fliR
AI20_RS12205	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AI20_RS12230	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AI20_RS12235	COG0643	Histidine kinase
AI20_RS12235	COG0784	Response regulator, receiver
AI20_RS12235	COG2198	Histidine kinase
AI20_RS12245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AI20_RS12255	COG1192	Involved in chromosome partitioning
AI20_RS12265	COG0835	chemotaxis
AI20_RS12280	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AI20_RS12285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AI20_RS12290	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AI20_RS12295	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AI20_RS12300	COG1138	Cytochrome C-type biogenesis protein
AI20_RS12305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AI20_RS12310	COG3088	subunit of a heme lyase
AI20_RS12310	COG4235	cytochrome complex assembly
AI20_RS12330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AI20_RS12335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AI20_RS12335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AI20_RS12350	COG0259	pyridoxamine-phosphate oxidase activity
AI20_RS12355	COG0625	glutathione transferase activity
AI20_RS12365	COG3153	acetyltransferase
AI20_RS12375	COG2850	peptidyl-arginine hydroxylation
AI20_RS12380	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AI20_RS12385	COG2915	High frequency lysogenization protein hflD homolog
AI20_RS12390	COG0482	sulfurtransferase activity
AI20_RS12400	COG1187	pseudouridine synthase activity
AI20_RS12410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_RS12420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_RS12420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_RS12420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_RS12430	COG0456	acetyltransferase
AI20_RS12440	COG1609	Transcriptional regulator
AI20_RS12445	COG1263	PTS System
AI20_RS12445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AI20_RS12450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AI20_RS12460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_RS12475	COG2207	Transcriptional regulator
AI20_RS12480	COG0538	isocitrate dehydrogenase activity
AI20_RS12485	COG0659	secondary active sulfate transmembrane transporter activity
AI20_RS12490	COG3048	D-serine ammonia-lyase activity
AI20_RS12495	COG0583	DNA-binding transcription factor activity
AI20_RS12520	COG0732	type I restriction modification DNA specificity domain
AI20_RS12540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AI20_RS12545	COG2867	negative regulation of translational initiation
AI20_RS12550	COG2914	Belongs to the UPF0125 (RnfH) family
AI20_RS12555	COG0702	epimerase
AI20_RS12560	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AI20_RS12565	COG1454	alcohol dehydrogenase
AI20_RS12575	COG0564	pseudouridine synthase activity
AI20_RS12580	COG1957	nucleoside hydrolase
AI20_RS12605	COG1280	lysine exporter protein (LysE YggA)
AI20_RS12625	COG3263	regulation of cellular component size
AI20_RS12630	COG1876	peptidase activity
AI20_RS12635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AI20_RS12640	COG1393	Belongs to the ArsC family
AI20_RS12645	COG0583	DNA-binding transcription factor activity
AI20_RS12655	COG3069	C4-dicarboxylate transmembrane transporter activity
AI20_RS12670	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AI20_RS12675	COG0017	Asparaginyl-tRNA synthetase
AI20_RS12695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AI20_RS12700	COG0156	8-amino-7-oxononanoate synthase activity
AI20_RS12705	COG0596	Alpha beta hydrolase
AI20_RS12705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AI20_RS12705	COG2226	methyltransferase
AI20_RS12710	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AI20_RS12715	COG0501	Belongs to the peptidase M48B family
AI20_RS12725	COG3217	Mosc domain protein beta barrel domain protein
AI20_RS12725	COG3217	Mosc domain protein beta barrel domain protein
AI20_RS12725	COG0633	Ferredoxin
AI20_RS12725	COG0633	Ferredoxin
AI20_RS12735	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AI20_RS12735	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AI20_RS12735	COG1013	pyruvate-flavodoxin oxidoreductase activity
AI20_RS12735	COG0674	pyruvate-flavodoxin oxidoreductase activity
AI20_RS12740	COG2366	antibiotic biosynthetic process
AI20_RS12745	COG2169	Transcriptional regulator
AI20_RS12745	COG1917	Cupin 2, conserved barrel domain protein
AI20_RS12750	COG2841	Protein conserved in bacteria
AI20_RS12760	COG0534	Mate efflux family protein
AI20_RS12800	COG1309	transcriptional regulator
AI20_RS12815	COG0791	NLP P60 protein
AI20_RS12825	COG0583	DNA-binding transcription factor activity
AI20_RS12830	COG0450	alkyl hydroperoxide reductase
AI20_RS12850	COG0500	methyltransferase
AI20_RS12855	COG4106	trans-aconitate 2-methyltransferase activity
AI20_RS12860	COG1801	Protein of unknown function DUF72
AI20_RS12865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AI20_RS12870	COG0217	transcriptional regulatory protein
AI20_RS12875	COG2194	sulfuric ester hydrolase activity
AI20_RS12880	COG1846	Transcriptional regulator
AI20_RS12880	COG1940	carbohydrate kinase activity
AI20_RS12885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AI20_RS12890	COG0363	glucosamine-6-phosphate deaminase activity
AI20_RS12895	COG1263	PTS System
AI20_RS12895	COG2190	(PTS) system
AI20_RS12895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AI20_RS12905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AI20_RS12910	COG0735	belongs to the Fur family
AI20_RS12920	COG0716	FMN binding
AI20_RS12935	COG0596	Alpha beta hydrolase
AI20_RS12940	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AI20_RS12945	COG0033	Phosphoglucomutase
AI20_RS12955	COG1846	Transcriptional regulator
AI20_RS12970	COG2951	lytic endotransglycosylase activity
AI20_RS12975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AI20_RS12980	COG4136	ATPase activity
AI20_RS12990	COG4134	Bacterial extracellular solute-binding protein
AI20_RS13000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AI20_RS13010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AI20_RS13015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AI20_RS13025	COG0729	surface antigen
AI20_RS13050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AI20_RS13060	COG0741	lytic transglycosylase activity
AI20_RS13075	COG1607	acyl-coa hydrolase
AI20_RS13085	COG3021	interspecies interaction between organisms
AI20_RS13090	COG1388	LysM domain
AI20_RS13090	COG0741	lytic transglycosylase activity
AI20_RS13095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AI20_RS13100	COG2226	methyltransferase
AI20_RS13105	COG0328	RNA-DNA hybrid ribonuclease activity
AI20_RS13110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AI20_RS13120	COG3437	response regulator, receiver
AI20_RS13120	COG0784	Response regulator, receiver
AI20_RS13125	COG1960	acyl-CoA dehydrogenase activity
AI20_RS13130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AI20_RS13135	COG0121	glutamine amidotransferase
AI20_RS13165	COG2197	response regulator
AI20_RS13170	COG3850	Histidine kinase
AI20_RS13175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AI20_RS13180	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_RS13180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_RS13190	COG0243	molybdopterin cofactor binding
AI20_RS13195	COG0437	4 iron, 4 sulfur cluster binding
AI20_RS13200	COG0348	domain, Protein
AI20_RS13210	COG3005	denitrification pathway
AI20_RS13215	COG0521	Mo-molybdopterin cofactor biosynthetic process
AI20_RS13220	COG0315	cyclic pyranopterin monophosphate synthase activity
AI20_RS13225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AI20_RS13230	COG0314	molybdopterin synthase activity
AI20_RS13245	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AI20_RS13250	COG2267	carboxylic ester hydrolase activity
AI20_RS13255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AI20_RS13265	COG0302	gtp cyclohydrolase
AI20_RS13270	COG0840	transmembrane signaling receptor activity
AI20_RS13275	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AI20_RS13285	COG0583	DNA-binding transcription factor activity
AI20_RS13315	COG2195	Cleaves the N-terminal amino acid of tripeptides
AI20_RS13325	COG1166	arginine decarboxylase activity
AI20_RS13335	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AI20_RS13340	COG0583	DNA-binding transcription factor activity
AI20_RS13355	COG0840	transmembrane signaling receptor activity
AI20_RS13360	COG0814	amino acid
AI20_RS13370	COG3681	Belongs to the UPF0597 family
AI20_RS13375	COG2964	Protein conserved in bacteria
AI20_RS13385	COG1403	HNH endonuclease
AI20_RS13405	COG1187	pseudouridine synthase activity
AI20_RS13415	COG2807	transmembrane transport
AI20_RS13425	COG0583	DNA-binding transcription factor activity
AI20_RS13430	COG2271	Major facilitator Superfamily
AI20_RS13455	COG2979	Protein of unknown function (DUF533)
AI20_RS13465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AI20_RS13475	COG1294	oxidase, subunit
AI20_RS13495	COG3220	belongs to the UPF0276 family
AI20_RS13510	COG2814	Major facilitator Superfamily
AI20_RS13515	COG0656	L-ascorbic acid biosynthetic process
AI20_RS13535	COG0583	DNA-binding transcription factor activity
AI20_RS13545	COG0840	transmembrane signaling receptor activity
AI20_RS13550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AI20_RS13555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AI20_RS13560	COG2271	Major facilitator Superfamily
AI20_RS13565	COG1349	DNA-binding transcription factor activity
AI20_RS13575	COG0584	glycerophosphoryl diester phosphodiesterase
AI20_RS13580	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AI20_RS13585	COG0287	Prephenate dehydrogenase
AI20_RS13585	COG1605	Chorismate mutase
AI20_RS13590	COG0583	DNA-binding transcription factor activity
AI20_RS13595	COG3085	chromosome segregation
AI20_RS13600	COG4574	serine-type endopeptidase inhibitor activity
AI20_RS13620	COG1770	oligopeptidase
AI20_RS13625	COG4771	TonB-dependent receptor
AI20_RS13630	COG3083	sulfuric ester hydrolase activity
AI20_RS13635	COG3082	Protein of unknown function (DUF1414)
AI20_RS13640	COG3081	Nucleoid-associated protein
AI20_RS13650	COG1175	transmembrane transport
AI20_RS13655	COG3833	ABC-type maltose transport systems, permease component
AI20_RS13660	COG3842	ATPase activity
AI20_RS13685	COG0425	Belongs to the sulfur carrier protein TusA family
AI20_RS13690	COG4783	chaperone-mediated protein folding
AI20_RS13700	COG1393	Belongs to the ArsC family
AI20_RS13720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AI20_RS13725	COG2431	L-lysine efflux transmembrane transporter activity
AI20_RS13735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_RS13760	COG1216	Glycosyl transferase, family 2
AI20_RS13770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AI20_RS13775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AI20_RS13805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AI20_RS13815	COG0446	pyridine nucleotide-disulphide oxidoreductase
AI20_RS13820	COG2373	Large extracellular alpha-helical protein
AI20_RS13825	COG4953	penicillin-binding protein 1C
AI20_RS13835	COG0301	tRNA thio-modification
AI20_RS13835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AI20_RS13855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AI20_RS13885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AI20_RS13895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AI20_RS13915	COG0483	inositol monophosphate 1-phosphatase activity
AI20_RS13925	COG0625	glutathione transferase activity
AI20_RS13930	COG2814	Major facilitator Superfamily
AI20_RS13950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AI20_RS13955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AI20_RS13960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AI20_RS13965	COG0509	glycine decarboxylation via glycine cleavage system
AI20_RS13970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AI20_RS13970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AI20_RS13975	COG0641	radical SAM
AI20_RS13980	COG3119	arylsulfatase activity
AI20_RS13995	COG3852	Histidine kinase
AI20_RS14000	COG0477	Major facilitator Superfamily
AI20_RS14005	COG3634	alkyl hydroperoxide reductase activity
AI20_RS14015	COG0517	IMP dehydrogenase activity
AI20_RS14020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AI20_RS14025	COG0343	queuine tRNA-ribosyltransferase activity
AI20_RS14030	COG1862	Preprotein translocase
AI20_RS14035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AI20_RS14040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AI20_RS14055	COG0826	peptidase U32
AI20_RS14060	COG0826	peptidase U32
AI20_RS14065	COG3154	lipid carrier protein
AI20_RS14085	COG1104	cysteine desulfurase activity
AI20_RS14090	COG0822	iron-sulfur transferase activity
AI20_RS14100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AI20_RS14105	COG0443	Heat shock 70 kDa protein
AI20_RS14110	COG0633	Ferredoxin
AI20_RS14120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AI20_RS14125	COG0105	UTP biosynthetic process
AI20_RS14130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AI20_RS14145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AI20_RS14150	COG0124	histidyl-tRNA synthetase
AI20_RS14155	COG2976	Protein conserved in bacteria
AI20_RS14160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AI20_RS14165	COG1160	GTP binding
AI20_RS14170	COG1645	bacterial-type flagellum-dependent swarming motility
AI20_RS14180	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AI20_RS14185	COG0047	phosphoribosylformylglycinamidine synthase activity
AI20_RS14185	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AI20_RS14190	COG2199	diguanylate cyclase activity
AI20_RS14190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AI20_RS14205	COG1007	ATP synthesis coupled electron transport
AI20_RS14210	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_RS14220	COG0713	ATP synthesis coupled electron transport
AI20_RS14225	COG0839	Belongs to the complex I subunit 6 family
AI20_RS14230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_RS14235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AI20_RS14240	COG1034	ATP synthesis coupled electron transport
AI20_RS14255	COG0649	NAD binding
AI20_RS14255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_RS14260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_RS14265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_RS14270	COG1360	Flagellar Motor Protein
AI20_RS14275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AI20_RS14300	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AI20_RS14320	COG0724	RNA recognition motif
AI20_RS14325	COG4989	oxidoreductase activity
AI20_RS14350	COG3437	response regulator, receiver
AI20_RS14355	COG0583	DNA-binding transcription factor activity
AI20_RS14365	COG3300	MHYT domain
AI20_RS14365	COG5001	Diguanylate cyclase
AI20_RS14370	COG0778	Nitroreductase
AI20_RS14390	COG0583	DNA-binding transcription factor activity
AI20_RS14400	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AI20_RS14405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AI20_RS14410	COG0539	negative regulation of cytoplasmic translation
AI20_RS14415	COG0776	regulation of translation
AI20_RS14425	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AI20_RS14445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AI20_RS14450	COG0602	queuosine metabolic process
AI20_RS14455	COG3530	Putative quorum-sensing-regulated virulence factor
AI20_RS14460	COG2096	Adenosyltransferase
AI20_RS14465	COG2916	Histone family protein nucleoid-structuring protein H-NS
AI20_RS14470	COG1757	Na H antiporter
AI20_RS14475	COG1435	thymidine kinase activity
AI20_RS14505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AI20_RS14525	COG3179	chitinase
AI20_RS14550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AI20_RS14555	COG1278	Cold shock
AI20_RS14560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AI20_RS14565	COG0542	response to heat
AI20_RS14570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AI20_RS14575	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AI20_RS14580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AI20_RS14585	COG3134	Outer membrane lipoprotein
AI20_RS14590	COG3706	GGDEF domain
AI20_RS14595	COG0492	ferredoxin-NADP+ reductase activity
AI20_RS14605	COG0531	amino acid
AI20_RS14605	COG1674	ftsk spoiiie
AI20_RS14610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AI20_RS14615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AI20_RS14620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AI20_RS14625	COG1286	toxin biosynthetic process
AI20_RS14630	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AI20_RS14640	COG4172	Belongs to the ABC transporter superfamily
AI20_RS14650	COG4171	peptide transport system, permease
AI20_RS14655	COG4168	peptide transport system, permease
AI20_RS14665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AI20_RS14670	COG1842	Phage shock protein A
AI20_RS14685	COG3106	COG3106 Predicted ATPase
AI20_RS14690	COG3768	UPF0283 membrane protein
AI20_RS14700	COG2154	pterin-4-alpha-carbinolamine dehydratase
AI20_RS14720	COG2885	chlorophyll binding
AI20_RS14725	COG0861	Integral membrane protein TerC family
AI20_RS14740	COG1022	Amp-dependent synthetase and ligase
AI20_RS14745	COG0295	cytidine deaminase activity
AI20_RS14750	COG1346	cytolysis
AI20_RS14755	COG1380	Effector of murein hydrolase LrgA
AI20_RS14760	COG3345	alpha-galactosidase
AI20_RS14770	COG2925	Exonuclease
AI20_RS14775	COG0583	DNA-binding transcription factor activity
AI20_RS14785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AI20_RS14790	COG0254	rRNA binding
AI20_RS14805	COG1451	nucleotide metabolic process
AI20_RS14820	COG3069	C4-dicarboxylate transmembrane transporter activity
AI20_RS14830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AI20_RS14830	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AI20_RS14835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AI20_RS14860	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AI20_RS14875	COG0567	Dehydrogenase, E1 component
AI20_RS14880	COG0508	dehydrogenase complex catalyzes the overall conversion of
AI20_RS14885	COG0045	succinate-CoA ligase (ADP-forming) activity
AI20_RS14890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AI20_RS14895	COG2983	Belongs to the UPF0260 family
AI20_RS14900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AI20_RS14910	COG3842	ATPase activity
AI20_RS14915	COG1840	ABC-type Fe3 transport system, periplasmic component
AI20_RS14925	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AI20_RS14935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AI20_RS14940	COG1882	Formate acetyltransferase
AI20_RS14945	COG2116	formate transmembrane transporter activity
AI20_RS14950	COG1944	ATP diphosphatase activity
AI20_RS14960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AI20_RS14965	COG0612	Peptidase, M16
AI20_RS14970	COG0626	cystathionine gamma-synthase activity
AI20_RS14980	COG2910	NAD(P)H-binding
AI20_RS14985	COG0583	DNA-binding transcription factor activity
AI20_RS14995	COG4977	sequence-specific DNA binding
AI20_RS15000	COG4774	siderophore transport
AI20_RS15015	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AI20_RS15035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AI20_RS15040	COG3046	protein related to deoxyribodipyrimidine photolyase
AI20_RS15045	COG3033	Beta-eliminating lyase
AI20_RS15060	COG4235	cytochrome complex assembly
AI20_RS15060	COG3088	subunit of a heme lyase
AI20_RS15065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AI20_RS15075	COG3301	Polysulphide reductase, NrfD
AI20_RS15080	COG0437	4 iron, 4 sulfur cluster binding
AI20_RS15085	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AI20_RS15100	COG0247	lactate metabolic process
AI20_RS15105	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AI20_RS15110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AI20_RS15115	COG3012	SEC-C Motif Domain Protein
AI20_RS15120	COG0840	transmembrane signaling receptor activity
AI20_RS15125	COG1940	carbohydrate kinase activity
AI20_RS15125	COG1846	Transcriptional regulator
AI20_RS15130	COG3290	protein histidine kinase activity
AI20_RS15135	COG4565	transcriptional regulatory protein
AI20_RS15155	COG1196	nuclear chromosome segregation
AI20_RS15155	COG0741	lytic transglycosylase activity
AI20_RS15155	COG0739	heme binding
AI20_RS15160	COG2985	domain, Protein
AI20_RS15160	COG0569	domain protein
AI20_RS15170	COG0556	nucleotide-excision repair
AI20_RS15180	COG0586	Pfam SNARE associated Golgi protein
AI20_RS15185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AI20_RS15190	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AI20_RS15195	COG2186	Transcriptional regulator
AI20_RS15200	COG2719	SpoVR family
AI20_RS15205	COG2718	Belongs to the UPF0229 family
AI20_RS15210	COG2766	serine protein kinase
AI20_RS15215	COG0514	ATP-dependent DNA helicase (RecQ)
AI20_RS15220	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AI20_RS15225	COG0814	amino acid
AI20_RS15260	COG0058	SHG alpha-glucan phosphorylase activity
AI20_RS15265	COG0471	metal ion transport
AI20_RS15270	COG3118	belongs to the thioredoxin family
AI20_RS15280	COG1132	(ABC) transporter
AI20_RS15285	COG1132	(ABC) transporter
AI20_RS15295	COG2501	S4 domain
AI20_RS15325	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AI20_RS15330	COG2329	Antibiotic biosynthesis monooxygenase
AI20_RS15370	COG0513	Belongs to the DEAD box helicase family
AI20_RS15375	COG0386	Belongs to the glutathione peroxidase family
AI20_RS15385	COG1181	Belongs to the D-alanine--D-alanine ligase family
AI20_RS15395	COG3148	PFAM DTW domain containing protein
AI20_RS15400	COG0730	response to heat
AI20_RS15405	COG0583	DNA-binding transcription factor activity
AI20_RS15420	COG3593	DNA synthesis involved in DNA repair
AI20_RS15475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AI20_RS15480	COG1011	Hydrolase
AI20_RS15485	COG1473	amidohydrolase
AI20_RS15490	COG0205	6-phosphofructokinase activity
AI20_RS15500	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AI20_RS15505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AI20_RS15515	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AI20_RS15520	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AI20_RS15525	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AI20_RS15540	COG0242	peptide deformylase activity
AI20_RS15565	COG0384	phenazine biosynthesis protein PhzF
AI20_RS15580	COG2824	Alkylphosphonate utilization operon protein PhnA
AI20_RS15610	COG3706	GGDEF domain
AI20_RS15620	COG2840	Smr protein MutS2
AI20_RS15625	COG2890	protein-(glutamine-N5) methyltransferase activity
AI20_RS15630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AI20_RS15640	COG0513	Belongs to the DEAD box helicase family
AI20_RS15645	COG0583	DNA-binding transcription factor activity
AI20_RS15655	COG0814	amino acid
AI20_RS15660	COG1609	Transcriptional regulator
AI20_RS15665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_RS15665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_RS15670	COG1105	Belongs to the carbohydrate kinase PfkB family
AI20_RS15675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_RS15675	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AI20_RS15675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AI20_RS15680	COG3313	Fe-S protein
AI20_RS15685	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AI20_RS15690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AI20_RS15700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AI20_RS15710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AI20_RS15730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AI20_RS15735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AI20_RS15740	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AI20_RS15745	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AI20_RS15750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AI20_RS15755	COG0072	phenylalanine-tRNA ligase activity
AI20_RS15755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AI20_RS15760	COG0776	regulation of translation
AI20_RS15765	COG0784	Response regulator, receiver
AI20_RS15765	COG2205	protein histidine kinase activity
AI20_RS15790	COG5001	Diguanylate cyclase
AI20_RS15790	COG3300	MHYT domain
AI20_RS15795	COG1609	Transcriptional regulator
AI20_RS15800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AI20_RS15805	COG1879	ABC-type sugar transport system periplasmic component
AI20_RS15810	COG1172	Belongs to the binding-protein-dependent transport system permease family
AI20_RS15815	COG1129	ABC transporter
AI20_RS15820	COG1869	D-ribose catabolic process
AI20_RS15840	COG0037	tRNA processing
AI20_RS15845	COG0589	response to stress
AI20_RS15850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AI20_RS15875	COG2010	Cytochrome c
AI20_RS15890	COG3278	Belongs to the heme-copper respiratory oxidase family
AI20_RS15900	COG1956	GAF domain-containing protein
AI20_RS15905	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AI20_RS15915	COG0308	aminopeptidase N
AI20_RS15925	COG2902	Dehydrogenase
AI20_RS15930	COG0167	dihydroorotate dehydrogenase activity
AI20_RS15945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AI20_RS15945	COG0116	Belongs to the methyltransferase superfamily
AI20_RS15955	COG0488	(ABC) transporter
AI20_RS15965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AI20_RS15970	COG1067	ATP-dependent peptidase activity
AI20_RS15980	COG3141	response to X-ray
AI20_RS15990	COG4221	oxidoreductase activity
AI20_RS16035	COG0372	Belongs to the citrate synthase family
AI20_RS16040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AI20_RS16050	COG2995	paraquat-inducible protein a
AI20_RS16055	COG3008	intermembrane lipid transfer
AI20_RS16060	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AI20_RS16060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AI20_RS16075	COG0084	hydrolase, TatD family'
AI20_RS16080	COG0470	DNA polymerase III
AI20_RS16085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AI20_RS16090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AI20_RS16095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AI20_RS16105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AI20_RS16110	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_RS16120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AI20_RS16125	COG0416	fatty acid biosynthetic process
AI20_RS16130	COG1399	metal-binding, possibly nucleic acid-binding protein
AI20_RS16140	COG0424	maF-like protein
AI20_RS16145	COG0546	phosphoglycolate phosphatase activity
AI20_RS16155	COG1530	ribonuclease E activity
AI20_RS16160	COG0306	phosphate transporter
AI20_RS16165	COG0717	Belongs to the dCTP deaminase family
AI20_RS16170	COG0572	uridine kinase
AI20_RS16175	COG0489	protein tyrosine kinase activity
AI20_RS16180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AI20_RS16180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AI20_RS16185	COG0625	glutathione transferase activity
AI20_RS16190	COG1254	Belongs to the acylphosphatase family
AI20_RS16195	COG0840	transmembrane signaling receptor activity
AI20_RS16200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AI20_RS16205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AI20_RS16220	COG0709	Synthesizes selenophosphate from selenide and ATP
AI20_RS16225	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AI20_RS16230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AI20_RS16235	COG3437	response regulator, receiver
AI20_RS16255	COG1643	Atp-dependent helicase
AI20_RS16260	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AI20_RS16260	COG0617	tRNA 3'-terminal CCA addition
AI20_RS16260	COG0517	IMP dehydrogenase activity
AI20_RS16270	COG3314	Sporulation integral membrane protein YlbJ
AI20_RS16280	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AI20_RS16285	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AI20_RS16290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AI20_RS16295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AI20_RS16300	COG2832	Protein of unknown function (DUF454)
AI20_RS16305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AI20_RS16325	COG0318	PFAM AMP-dependent synthetase and ligase
AI20_RS16330	COG1073	alpha beta
AI20_RS16330	COG2226	methyltransferase
AI20_RS16340	COG1214	PFAM Peptidase M22, glycoprotease
AI20_RS16345	COG1199	ATP-dependent helicase activity
AI20_RS16355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AI20_RS16360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AI20_RS16365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AI20_RS16370	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AI20_RS16370	COG0131	Imidazoleglycerol-phosphate dehydratase
AI20_RS16375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AI20_RS16380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AI20_RS16385	COG3437	response regulator, receiver
AI20_RS16390	COG2199	diguanylate cyclase activity
AI20_RS16395	COG0784	Response regulator, receiver
AI20_RS16395	COG2198	Histidine kinase
AI20_RS16395	COG2205	protein histidine kinase activity
AI20_RS16400	COG0107	imidazoleglycerol-phosphate synthase activity
AI20_RS16405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AI20_RS16405	COG0140	phosphoribosyl-ATP diphosphatase activity
AI20_RS16415	COG2378	regulation of single-species biofilm formation
AI20_RS16420	COG0318	PFAM AMP-dependent synthetase and ligase
AI20_RS16425	COG1288	antiporter activity
AI20_RS16435	COG3134	Outer membrane lipoprotein
AI20_RS16445	COG2080	2 iron, 2 sulfur cluster binding
AI20_RS16450	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AI20_RS16455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AI20_RS16460	COG2252	PERMEase
AI20_RS16465	COG0402	S-adenosylhomocysteine deaminase activity
AI20_RS16470	COG2233	PERMEase
AI20_RS16475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AI20_RS16475	COG2080	2 iron, 2 sulfur cluster binding
AI20_RS16480	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AI20_RS16485	COG0402	S-adenosylhomocysteine deaminase activity
AI20_RS16490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_RS16490	COG0493	'glutamate synthase
AI20_RS16500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AI20_RS16505	COG3608	succinylglutamate desuccinylase aspartoacylase
AI20_RS16505	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AI20_RS16510	COG0697	spore germination
AI20_RS16515	COG0549	Belongs to the carbamate kinase family
AI20_RS16525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AI20_RS16530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AI20_RS16535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AI20_RS16540	COG3829	transcription factor binding
AI20_RS16560	COG1024	Enoyl-CoA hydratase
AI20_RS16560	COG1250	3-hydroxyacyl-CoA dehydrogenase
AI20_RS16565	COG0183	Belongs to the thiolase family
AI20_RS16570	COG0714	Associated with various cellular activities
AI20_RS16600	COG1595	DNA-templated transcription, initiation
AI20_RS16615	COG2067	long-chain fatty acid transport protein
AI20_RS16620	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AI20_RS16640	COG3123	guanosine phosphorylase activity
AI20_RS16645	COG1760	l-serine dehydratase
AI20_RS16650	COG1760	l-serine dehydratase
AI20_RS16655	COG2951	lytic endotransglycosylase activity
AI20_RS16660	COG3100	YcgL domain-containing protein
AI20_RS16665	COG0850	regulation of cytokinetic process
AI20_RS16670	COG2894	cell division
AI20_RS16675	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AI20_RS16680	COG3099	Belongs to the UPF0263 family
AI20_RS16685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AI20_RS16725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AI20_RS16730	COG0697	spore germination
AI20_RS16735	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AI20_RS16740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AI20_RS16755	COG0307	riboflavin synthase, alpha
AI20_RS16765	COG0534	Mate efflux family protein
AI20_RS16795	COG0417	DNA replication proofreading
AI20_RS16805	COG2203	Gaf domain
AI20_RS16805	COG2199	diguanylate cyclase activity
AI20_RS16820	COG1560	Kdo2-lipid A biosynthetic process
AI20_RS16825	COG1560	Kdo2-lipid A biosynthetic process
AI20_RS16835	COG0583	DNA-binding transcription factor activity
AI20_RS16840	COG0673	inositol 2-dehydrogenase activity
AI20_RS16845	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AI20_RS16850	COG0583	DNA-binding transcription factor activity
AI20_RS16860	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AI20_RS16865	COG2723	6-phospho-beta-galactosidase activity
AI20_RS16870	COG0583	DNA-binding transcription factor activity
AI20_RS16890	COG0667	Aldo Keto reductase
AI20_RS16895	COG0583	DNA-binding transcription factor activity
AI20_RS16900	COG0702	epimerase
AI20_RS16905	COG1073	alpha beta
AI20_RS16910	COG1073	alpha beta
AI20_RS16925	COG0730	response to heat
AI20_RS16935	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_RS16945	COG1024	Enoyl-CoA hydratase
AI20_RS16950	COG1024	Enoyl-CoA hydratase
AI20_RS16955	COG1960	acyl-CoA dehydrogenase activity
AI20_RS16965	COG1960	acyl-CoA dehydrogenase activity
AI20_RS16970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AI20_RS17005	COG1584	GPR1 FUN34 yaaH family protein
AI20_RS17020	COG1115	amino acid carrier protein
AI20_RS17025	COG1024	Enoyl-CoA hydratase
AI20_RS17040	COG3162	membrane
AI20_RS17045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AI20_RS17050	COG0488	(ABC) transporter
AI20_RS17055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AI20_RS17060	COG0776	regulation of translation
AI20_RS17065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AI20_RS17070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AI20_RS17075	COG0740	serine-type endopeptidase activity
AI20_RS17080	COG0544	peptidyl-prolyl cis-trans isomerase activity
AI20_RS17090	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AI20_RS17095	COG4591	ABC-type transport system involved in lipoprotein release permease component
AI20_RS17100	COG1136	(ABC) transporter
AI20_RS17105	COG4591	ABC-type transport system involved in lipoprotein release permease component
AI20_RS17115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AI20_RS17120	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AI20_RS17125	COG4166	transmembrane transport
AI20_RS17130	COG0697	spore germination
AI20_RS17140	COG2062	phosphohistidine phosphatase, SixA
AI20_RS17175	COG0519	Catalyzes the synthesis of GMP from XMP
AI20_RS17175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AI20_RS17180	COG0516	GMP reductase activity
AI20_RS17180	COG0517	IMP dehydrogenase activity
AI20_RS17185	COG3158	transport of potassium into the cell
AI20_RS17205	COG0697	spore germination
AI20_RS17210	COG1570	exodeoxyribonuclease VII activity
AI20_RS17225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AI20_RS17230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AI20_RS17235	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AI20_RS17275	COG4771	TonB-dependent receptor
AI20_RS17280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AI20_RS17285	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AI20_RS17290	COG1120	ATPase activity
AI20_RS17295	COG2977	Belongs to the P-Pant transferase superfamily
AI20_RS17300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AI20_RS17305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AI20_RS17315	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_RS17320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AI20_RS17325	COG1535	isochorismatase
AI20_RS17325	COG3433	isochorismatase activity
AI20_RS17330	COG1021	2,3-dihydroxybenzoate-AMP ligase
AI20_RS17350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AI20_RS17355	COG5001	Diguanylate cyclase
AI20_RS17355	COG3300	MHYT domain
AI20_RS17370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AI20_RS17375	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AI20_RS17380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AI20_RS17385	COG0563	adenylate kinase activity
AI20_RS17390	COG0326	Molecular chaperone. Has ATPase activity
AI20_RS17395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AI20_RS17415	COG3383	formate dehydrogenase (NAD+) activity
AI20_RS17420	COG3383	formate dehydrogenase (NAD+) activity
AI20_RS17425	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_RS17430	COG3158	transport of potassium into the cell
AI20_RS17435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AI20_RS17440	COG0651	ATP synthesis coupled electron transport
AI20_RS17445	COG0650	Formate hydrogenlyase subunit 4
AI20_RS17450	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AI20_RS17450	COG3261	NADH dehydrogenase
AI20_RS17455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_RS17460	COG3260	NADH ubiquinone oxidoreductase 20
AI20_RS17470	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AI20_RS17475	COG1921	L-seryl-tRNASec selenium transferase activity
AI20_RS17485	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AI20_RS17490	COG0298	carbon dioxide binding
AI20_RS17500	COG0309	Hydrogenase expression formation protein (HypE)
AI20_RS17505	COG0375	protein maturation
AI20_RS17510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AI20_RS17515	COG3842	ATPase activity
AI20_RS17520	COG0444	Belongs to the ABC transporter superfamily
AI20_RS17525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AI20_RS17535	COG0747	negative chemotaxis
AI20_RS17540	COG1773	rubredoxin
AI20_RS17545	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AI20_RS17550	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AI20_RS17555	COG5557	Pfam Polysulphide reductase, NrfD
AI20_RS17560	COG0437	4 iron, 4 sulfur cluster binding
AI20_RS17565	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AI20_RS17570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AI20_RS17590	COG0659	secondary active sulfate transmembrane transporter activity
AI20_RS17630	COG0672	)-iron permease
AI20_RS17650	COG2814	Major facilitator Superfamily
AI20_RS17670	COG1136	(ABC) transporter
AI20_RS17675	COG0577	efflux transmembrane transporter activity
AI20_RS17695	COG1139	Iron-sulfur cluster binding protein
AI20_RS17700	COG0247	lactate metabolic process
AI20_RS17705	COG1620	l-lactate permease
AI20_RS17710	COG0583	DNA-binding transcription factor activity
AI20_RS17715	COG0596	Alpha beta hydrolase
AI20_RS17735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AI20_RS17740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AI20_RS17740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AI20_RS17745	COG0527	aspartate kinase activity
AI20_RS17755	COG1368	sulfuric ester hydrolase activity
AI20_RS17760	COG1619	proteins homologs of microcin C7 resistance protein MccF
AI20_RS17770	COG0393	Putative heavy-metal-binding
AI20_RS17790	COG1252	NADH dehydrogenase
AI20_RS17795	COG3150	esterase
AI20_RS17800	COG2233	PERMEase
AI20_RS17815	COG2354	Protein conserved in bacteria
AI20_RS17830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AI20_RS17835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AI20_RS17870	COG0537	adenosine 5'-monophosphoramidase activity
AI20_RS17885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AI20_RS17900	COG1301	dicarboxylic acid transport
AI20_RS17910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AI20_RS17915	COG0861	Integral membrane protein TerC family
AI20_RS17925	COG0444	Belongs to the ABC transporter superfamily
AI20_RS17930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AI20_RS17935	COG0601	transmembrane transport
AI20_RS17945	COG2095	MarC family integral membrane protein
AI20_RS17955	COG1012	belongs to the aldehyde dehydrogenase family
AI20_RS17955	COG1454	alcohol dehydrogenase
AI20_RS17960	COG2199	diguanylate cyclase activity
AI20_RS17960	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AI20_RS17965	COG3275	phosphorelay sensor kinase activity
AI20_RS17970	COG3279	Response regulator of the LytR AlgR family
AI20_RS17975	COG1966	Carbon starvation protein
AI20_RS17985	COG1566	PFAM secretion protein HlyD family protein
AI20_RS17990	COG1061	Type III restriction enzyme res subunit
AI20_RS17995	COG2027	D-alanyl-D-alanine carboxypeptidase
AI20_RS18000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AI20_RS18010	COG0436	Aminotransferase
AI20_RS18015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AI20_RS18015	COG3264	Mechanosensitive ion channel
AI20_RS18020	COG1288	antiporter activity
AI20_RS18025	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AI20_RS18040	COG0697	spore germination
AI20_RS18045	COG4657	Part of a membrane complex involved in electron transport
AI20_RS18050	COG2878	Part of a membrane complex involved in electron transport
AI20_RS18060	COG4658	electron transport chain
AI20_RS18065	COG4659	FMN binding
AI20_RS18070	COG4660	Part of a membrane complex involved in electron transport
AI20_RS18075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AI20_RS18080	COG0346	lactoylglutathione lyase activity
AI20_RS18085	COG2885	chlorophyll binding
AI20_RS18095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AI20_RS18100	COG2056	Na+-H+ antiporter family
AI20_RS18110	COG2050	protein possibly involved in aromatic compounds catabolism
AI20_RS18120	COG0247	lactate metabolic process
AI20_RS18120	COG0277	FAD linked oxidase domain protein
AI20_RS18130	COG1253	flavin adenine dinucleotide binding
AI20_RS18135	COG1902	pentaerythritol trinitrate reductase activity
AI20_RS18140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AI20_RS18145	COG0647	UMP catabolic process
AI20_RS18150	COG4651	solute:proton antiporter activity
AI20_RS18150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AI20_RS18160	COG0367	asparagine synthase
AI20_RS18170	COG0625	glutathione transferase activity
AI20_RS18180	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AI20_RS18195	COG0564	pseudouridine synthase activity
AI20_RS18200	COG5001	Diguanylate cyclase
AI20_RS18205	COG0840	transmembrane signaling receptor activity
AI20_RS18215	COG0392	lysyltransferase activity
AI20_RS18215	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AI20_RS18220	COG2194	sulfuric ester hydrolase activity
AI20_RS18240	COG0670	Belongs to the BI1 family
AI20_RS18245	COG1289	transmembrane transporter activity
AI20_RS18250	COG2920	part of a sulfur-relay system
AI20_RS18255	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AI20_RS18260	COG0285	dihydrofolate synthase activity
AI20_RS18265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AI20_RS18270	COG0101	tRNA pseudouridine synthase activity
AI20_RS18280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AI20_RS18285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AI20_RS18290	COG0671	phosphoesterase, PA-phosphatase related
AI20_RS18295	COG1464	Belongs to the NlpA lipoprotein family
AI20_RS18340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AI20_RS18340	COG0574	Belongs to the PEP-utilizing enzyme family
AI20_RS18345	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AI20_RS18420	COG1242	4 iron, 4 sulfur cluster binding
AI20_RS18425	COG0070	glutamate synthase
AI20_RS18425	COG0069	glutamate synthase activity
AI20_RS18425	COG0067	glutamate synthase
AI20_RS18430	COG0493	'glutamate synthase
AI20_RS18445	COG0789	Transcriptional regulator
AI20_RS18460	COG4104	PAAR repeat-containing protein
AI20_RS18470	COG0513	Belongs to the DEAD box helicase family
AI20_RS18475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AI20_RS18515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AI20_RS18520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AI20_RS18525	COG0505	Belongs to the CarA family
AI20_RS18530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AI20_RS18540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AI20_RS18545	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AI20_RS18550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AI20_RS18555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AI20_RS18560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AI20_RS18565	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AI20_RS18575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_RS18575	COG2205	protein histidine kinase activity
AI20_RS18615	COG0023	Translation Initiation Factor
AI20_RS18620	COG2119	membrane
AI20_RS18650	COG2199	diguanylate cyclase activity
AI20_RS18650	COG2203	Gaf domain
AI20_RS18665	COG0215	cysteine-tRNA ligase activity
AI20_RS18670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AI20_RS18680	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AI20_RS18685	COG3301	Polysulphide reductase, NrfD
AI20_RS18690	COG0437	4 iron, 4 sulfur cluster binding
AI20_RS18695	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AI20_RS18770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AI20_RS18800	COG4974	Belongs to the 'phage' integrase family
AI20_RS18825	COG0322	excinuclease ABC activity
AI20_RS18830	COG2197	response regulator
AI20_RS18835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AI20_RS18840	COG2835	tetraacyldisaccharide 4'-kinase activity
AI20_RS18845	COG1663	tetraacyldisaccharide 4'-kinase activity
AI20_RS18855	COG0658	competence protein
AI20_RS18855	COG2333	competence protein COMEC
AI20_RS18870	COG0433	COG0433 Predicted ATPase
AI20_RS18875	COG1448	Aminotransferase
AI20_RS18890	COG1199	ATP-dependent helicase activity
AI20_RS18900	COG0123	including yeast histone deacetylase and acetoin utilization protein
AI20_RS18905	COG0477	Major facilitator Superfamily
AI20_RS18910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AI20_RS18935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AI20_RS18950	COG2271	Major facilitator Superfamily
AI20_RS18955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_RS18960	COG0765	amino acid transport
AI20_RS18985	COG0531	amino acid
AI20_RS19000	COG1253	flavin adenine dinucleotide binding
AI20_RS19020	COG0704	Plays a role in the regulation of phosphate uptake
AI20_RS19025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AI20_RS19030	COG0581	inorganic phosphate transmembrane transporter activity
AI20_RS19035	COG0573	inorganic phosphate transmembrane transporter activity
AI20_RS19040	COG0590	tRNA wobble adenosine to inosine editing
AI20_RS19050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AI20_RS19070	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AI20_RS19075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AI20_RS19080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AI20_RS19085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AI20_RS19110	COG2716	regulation of RNA biosynthetic process
AI20_RS19115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AI20_RS19125	COG2239	Acts as a magnesium transporter
AI20_RS19135	COG1256	bacterial-type flagellum assembly
AI20_RS19140	COG3951	Flagellar rod assembly protein muramidase FlgJ
AI20_RS19140	COG1705	Flagellar rod assembly protein muramidase FlgJ
AI20_RS19145	COG1706	bacterial-type flagellum-dependent cell motility
AI20_RS19150	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AI20_RS19160	COG4787	bacterial-type flagellum-dependent cell motility
AI20_RS19180	COG1815	bacterial-type flagellum-dependent cell motility
AI20_RS19185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AI20_RS19190	COG0835	chemotaxis
AI20_RS19190	COG0784	Response regulator, receiver
AI20_RS19195	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AI20_RS19210	COG0622	Phosphoesterase
AI20_RS19215	COG4166	transmembrane transport
AI20_RS19240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AI20_RS19245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AI20_RS19250	COG1882	Formate acetyltransferase
AI20_RS19255	COG1349	DNA-binding transcription factor activity
AI20_RS19260	COG0697	spore germination
AI20_RS19265	COG4166	transmembrane transport
AI20_RS19290	COG1278	Cold shock
AI20_RS19330	COG3132	Protein of unknown function, DUF480
AI20_RS19350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AI20_RS19400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AI20_RS19415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_RS19420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_RS19425	COG1309	transcriptional regulator
AI20_RS19440	COG1946	Acyl-CoA thioesterase
AI20_RS19450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AI20_RS19460	COG0009	L-threonylcarbamoyladenylate synthase
AI20_RS19470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AI20_RS19475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AI20_RS19475	COG0512	Glutamine amidotransferase of anthranilate synthase
AI20_RS19480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AI20_RS19485	COG0135	phosphoribosylanthranilate isomerase activity
AI20_RS19485	COG0134	indole-3-glycerol-phosphate synthase activity
AI20_RS19490	COG0133	tryptophan synthase activity
AI20_RS19495	COG0159	tryptophan synthase activity
AI20_RS19510	COG1988	membrane-bound metal-dependent
AI20_RS19520	COG1988	membrane-bound metal-dependent
AI20_RS19540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AI20_RS19550	COG4521	taurine ABC transporter
AI20_RS19555	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AI20_RS19560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AI20_RS19565	COG2175	clavaminate synthase activity
AI20_RS19575	COG2814	Major facilitator Superfamily
AI20_RS19580	COG0109	protoheme IX farnesyltransferase activity
AI20_RS19585	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AI20_RS19590	COG1845	cytochrome c oxidase, subunit III
AI20_RS19595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AI20_RS19600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AI20_RS19605	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AI20_RS19645	COG2211	Major facilitator Superfamily
AI20_RS19650	COG0071	Belongs to the small heat shock protein (HSP20) family
AI20_RS19665	COG0708	Exodeoxyribonuclease III
AI20_RS19690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_RS19695	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AI20_RS19710	COG0095	Lipoate-protein ligase
AI20_RS19740	COG0640	Transcriptional regulator
AI20_RS19755	COG1285	pathogenesis
AI20_RS19785	COG0484	heat shock protein binding
AI20_RS19790	COG0443	Heat shock 70 kDa protein
AI20_RS19795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AI20_RS19800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AI20_RS19805	COG0497	DNA recombination
AI20_RS19810	COG1227	inorganic diphosphatase activity
AI20_RS19820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AI20_RS19825	COG1136	(ABC) transporter
AI20_RS19825	COG0577	efflux transmembrane transporter activity
AI20_RS19835	COG2375	cellular response to nickel ion
AI20_RS19840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AI20_RS19860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AI20_RS19865	COG1917	Cupin 2, conserved barrel domain protein
AI20_RS19865	COG1396	sequence-specific DNA binding
AI20_RS19880	COG0531	amino acid
AI20_RS19885	COG0531	amino acid
AI20_RS19895	COG1283	sodium-dependent phosphate transmembrane transporter activity
AI20_RS19905	COG3384	dioxygenase
AI20_RS19910	COG0784	Response regulator, receiver
AI20_RS19910	COG2205	protein histidine kinase activity
AI20_RS19910	COG5002	protein histidine kinase activity
AI20_RS19915	COG2203	Gaf domain
AI20_RS19915	COG3706	GGDEF domain
AI20_RS19915	COG4251	negative regulation of phosphorylation
AI20_RS19915	COG5001	Diguanylate cyclase
AI20_RS19920	COG2205	protein histidine kinase activity
AI20_RS19920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_RS19935	COG0813	purine-nucleoside phosphorylase activity
AI20_RS19945	COG0488	(ABC) transporter
AI20_RS19960	COG4319	ketosteroid isomerase
AI20_RS19965	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AI20_RS19970	COG0083	homoserine kinase activity
AI20_RS19980	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AI20_RS19985	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AI20_RS20000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AI20_RS20010	COG0745	RESPONSE REGULATOR receiver
AI20_RS20025	COG4988	ABC transporter
AI20_RS20030	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AI20_RS20050	COG1720	tRNA m6t6A37 methyltransferase activity
AI20_RS20055	COG3437	response regulator, receiver
AI20_RS20055	COG2770	Histidine kinase
AI20_RS20070	COG0542	response to heat
AI20_RS20075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AI20_RS20080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AI20_RS20085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AI20_RS20090	COG2190	(PTS) system
AI20_RS20100	COG3038	cytochrome b561
AI20_RS20110	COG0419	ATPase involved in DNA repair
AI20_RS20115	COG0420	3'-5' exonuclease activity
AI20_RS20125	COG2974	May be involved in recombination
AI20_RS20135	COG4651	solute:proton antiporter activity
AI20_RS20135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AI20_RS20150	COG0469	pyruvate kinase activity
AI20_RS20155	COG3264	Mechanosensitive ion channel
AI20_RS20155	COG1196	nuclear chromosome segregation
AI20_RS20180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AI20_RS20200	COG0281	malic enzyme
AI20_RS20210	COG0437	4 iron, 4 sulfur cluster binding
AI20_RS20215	COG3383	formate dehydrogenase (NAD+) activity
AI20_RS20215	COG3383	formate dehydrogenase (NAD+) activity
AI20_RS20245	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AI20_RS20250	COG1910	domain protein
AI20_RS20255	COG3852	Histidine kinase
AI20_RS20270	COG4662	Binding-protein-dependent transport system inner membrane component
AI20_RS20280	COG0746	molybdenum cofactor guanylyltransferase activity
AI20_RS20285	COG0303	'Molybdopterin
AI20_RS20290	COG1289	transmembrane transporter activity
AI20_RS20295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AI20_RS20325	COG3220	belongs to the UPF0276 family
AI20_RS20365	COG2205	protein histidine kinase activity
AI20_RS20365	COG0784	Response regulator, receiver
AI20_RS20370	COG4166	transmembrane transport
AI20_RS20375	COG0601	transmembrane transport
AI20_RS20380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AI20_RS20385	COG0444	Belongs to the ABC transporter superfamily
AI20_RS20390	COG4608	Belongs to the ABC transporter superfamily
AI20_RS20400	COG2971	BadF BadG BcrA BcrD
AI20_RS20410	COG0840	transmembrane signaling receptor activity
AI20_RS20425	COG3724	N-succinylarginine dihydrolase activity
AI20_RS20430	COG0616	signal peptide processing
AI20_RS20435	COG1028	Short-chain dehydrogenase reductase Sdr
AI20_RS20440	COG0583	DNA-binding transcription factor activity
AI20_RS20450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AI20_RS20460	COG0583	DNA-binding transcription factor activity
AI20_RS20465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AI20_RS20470	COG1881	PFAM PEBP family protein
AI20_RS20480	COG3408	Glycogen debranching enzyme
AI20_RS20480	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AI20_RS20485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AI20_RS20490	COG0739	heme binding
AI20_RS20495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AI20_RS20510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AI20_RS20520	COG3091	SprT-like family
AI20_RS20530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AI20_RS20535	COG0189	ligase activity
AI20_RS20545	COG1678	Uncharacterized ACR, COG1678
AI20_RS20550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AI20_RS20555	COG3104	oligopeptide transport
AI20_RS20565	COG0714	Associated with various cellular activities
AI20_RS20580	COG1115	amino acid carrier protein
AI20_RS20585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AI20_RS20600	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AI20_RS20610	COG1301	dicarboxylic acid transport
AI20_RS20615	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AI20_RS20620	COG2912	Transglutaminase-like superfamily
AI20_RS20630	COG2890	protein-(glutamine-N5) methyltransferase activity
AI20_RS20635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AI20_RS20640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AI20_RS20645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AI20_RS20650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AI20_RS20660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AI20_RS20665	COG0737	Belongs to the 5'-nucleotidase family
AI20_RS20670	COG0193	aminoacyl-tRNA hydrolase activity
AI20_RS20675	COG0012	GTP binding
AI20_RS20720	COG0471	metal ion transport
AI20_RS20720	COG0490	domain, Protein
AI20_RS20730	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AI20_RS20750	COG0366	Alpha amylase catalytic
AI20_RS20765	COG0488	(ABC) transporter
AI20_RS20795	COG0674	pyruvate-flavodoxin oxidoreductase activity
AI20_RS20795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AI20_RS20795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AI20_RS20795	COG1013	pyruvate-flavodoxin oxidoreductase activity
AI20_RS20805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AI20_RS20815	COG1012	belongs to the aldehyde dehydrogenase family
AI20_RS20825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AI20_RS20840	COG0180	Tryptophanyl-tRNA synthetase
AI20_RS20850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AI20_RS20855	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AI20_RS20865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AI20_RS20870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AI20_RS20900	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AI20_RS20905	COG0583	DNA-binding transcription factor activity
AI20_RS20925	COG0583	DNA-binding transcription factor activity
AI20_RS20940	COG0739	heme binding
AI20_RS20950	COG3264	Mechanosensitive ion channel
AI20_RS20950	COG1511	domain protein
AI20_RS20955	COG0584	glycerophosphoryl diester phosphodiesterase
AI20_RS20965	COG1053	succinate dehydrogenase
AI20_RS20970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AI20_RS20975	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AI20_RS21000	COG3214	Protein conserved in bacteria
AI20_RS21040	COG0642	Histidine kinase
AI20_RS21050	COG0516	GMP reductase activity
AI20_RS21060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AI20_RS21065	COG3647	Membrane
AI20_RS21075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AI20_RS21095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AI20_RS21110	COG3706	GGDEF domain
AI20_RS21120	COG1335	isochorismatase
AI20_RS21125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AI20_RS21130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AI20_RS21135	COG1702	phosphate starvation-inducible protein PhoH
AI20_RS21140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AI20_RS21145	COG4535	Mg2 and Co2 transporter CorC
AI20_RS21150	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AI20_RS21155	COG2888	peptidyl-tyrosine sulfation
AI20_RS21160	COG0495	leucyl-tRNA aminoacylation
AI20_RS21175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AI20_RS21180	COG0799	negative regulation of ribosome biogenesis
AI20_RS21185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AI20_RS21190	COG0768	penicillin binding
AI20_RS21195	COG0772	Belongs to the SEDS family
AI20_RS21200	COG2951	lytic endotransglycosylase activity
AI20_RS21205	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AI20_RS21210	COG1686	Belongs to the peptidase S11 family
AI20_RS21215	COG2921	Belongs to the UPF0250 family
AI20_RS21220	COG0321	lipoyl(octanoyl) transferase activity
AI20_RS21225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AI20_RS21230	COG3545	Serine hydrolase
AI20_RS21250	COG0789	Transcriptional regulator
AI20_RS21255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AI20_RS21265	COG1970	mechanosensitive ion channel activity
AI20_RS21275	COG4974	Belongs to the 'phage' integrase family
AI20_RS21285	COG0312	modulator of DNA gyrase
AI20_RS21295	COG0312	modulator of DNA gyrase
AI20_RS21365	COG0114	fumarate hydratase activity
AI20_RS21375	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE