locus-tag	class	description
C1A23_RS00050	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C1A23_RS00435	COG2176	DNA-directed DNA polymerase activity
C1A23_RS00435	COG5002	protein histidine kinase activity
C1A23_RS00540	COG3385	transposase activity
C1A23_RS00570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1A23_RS00575	COG0625	glutathione transferase activity
C1A23_RS00600	COG1192	Involved in chromosome partitioning
C1A23_RS00620	COG1484	DNA-dependent DNA replication
C1A23_RS00625	COG4584	PFAM Integrase catalytic
C1A23_RS00635	COG2194	sulfuric ester hydrolase activity
C1A23_RS00725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1A23_RS00750	COG1660	Displays ATPase and GTPase activities
C1A23_RS00775	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1A23_RS00780	COG4804	nuclease activity
C1A23_RS00790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1A23_RS00895	COG1357	PFAM Pentapeptide repeats (8 copies)
C1A23_RS00915	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1A23_RS00980	COG4584	PFAM Integrase catalytic
C1A23_RS00985	COG1484	DNA-dependent DNA replication
C1A23_RS01025	COG5433	transposase activity
C1A23_RS01040	COG5001	Diguanylate cyclase
C1A23_RS01040	COG3300	MHYT domain
C1A23_RS01050	COG5433	transposase activity
C1A23_RS01065	COG3039	Transposase
C1A23_RS01070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1A23_RS01080	COG0166	Belongs to the GPI family
C1A23_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
C1A23_RS01120	COG1349	DNA-binding transcription factor activity
C1A23_RS01135	COG3385	transposase activity
C1A23_RS01150	COG2200	EAL domain
C1A23_RS01155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1A23_RS01250	COG1484	DNA-dependent DNA replication
C1A23_RS01255	COG4584	PFAM Integrase catalytic
C1A23_RS01305	COG0675	Transposase, IS605 OrfB family
C1A23_RS01360	COG0675	Transposase, IS605 OrfB family
C1A23_RS01400	COG1192	Involved in chromosome partitioning
C1A23_RS01415	COG0675	Transposase, IS605 OrfB family
C1A23_RS01475	COG0675	Transposase, IS605 OrfB family
C1A23_RS01505	COG0305	Participates in initiation and elongation during chromosome replication
C1A23_RS01590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1A23_RS01700	COG5002	protein histidine kinase activity
C1A23_RS01700	COG2176	DNA-directed DNA polymerase activity
C1A23_RS01725	COG0393	Putative heavy-metal-binding
C1A23_RS01735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1A23_RS01760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1A23_RS01765	COG0592	DNA-directed DNA polymerase activity
C1A23_RS01770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1A23_RS01795	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1A23_RS01855	COG1484	DNA-dependent DNA replication
C1A23_RS01860	COG4584	PFAM Integrase catalytic
C1A23_RS01870	COG0071	Belongs to the small heat shock protein (HSP20) family
C1A23_RS01875	COG0071	Belongs to the small heat shock protein (HSP20) family
C1A23_RS01880	COG3977	Valine--pyruvate aminotransferase
C1A23_RS01895	COG2814	Major facilitator Superfamily
C1A23_RS01900	COG0745	RESPONSE REGULATOR receiver
C1A23_RS01905	COG2205	protein histidine kinase activity
C1A23_RS01930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1A23_RS01935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A23_RS01935	COG4191	Histidine kinase
C1A23_RS01940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1A23_RS01945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A23_RS01950	COG1309	transcriptional regulator
C1A23_RS01980	COG0561	phosphatase activity
C1A23_RS01985	COG2267	carboxylic ester hydrolase activity
C1A23_RS01990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1A23_RS01995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1A23_RS02000	COG1758	RNA polymerase activity
C1A23_RS02010	COG0859	PFAM glycosyl transferase family 9
C1A23_RS02015	COG3642	lipopolysaccharide core region biosynthetic process
C1A23_RS02055	COG0589	response to stress
C1A23_RS02060	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1A23_RS02070	COG1528	Iron-storage protein
C1A23_RS02075	COG2081	HI0933 family
C1A23_RS02080	COG2223	nitrite transmembrane transporter activity
C1A23_RS02100	COG3121	Chaperone
C1A23_RS02105	COG3188	usher protein
C1A23_RS02120	COG5433	transposase activity
C1A23_RS02125	COG2197	response regulator
C1A23_RS02130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A23_RS02130	COG2205	protein histidine kinase activity
C1A23_RS02140	COG3275	phosphorelay sensor kinase activity
C1A23_RS02145	COG3279	Response regulator of the LytR AlgR family
C1A23_RS02150	COG2223	nitrite transmembrane transporter activity
C1A23_RS02155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1A23_RS02160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1A23_RS02175	COG0583	DNA-binding transcription factor activity
C1A23_RS02180	COG4206	TonB-dependent receptor
C1A23_RS02185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1A23_RS02220	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C1A23_RS02225	COG2166	iron-sulfur cluster assembly
C1A23_RS02230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1A23_RS02235	COG0210	DNA helicase
C1A23_RS02245	COG3245	cytochrome
C1A23_RS02250	COG1063	alcohol dehydrogenase
C1A23_RS02255	COG0156	8-amino-7-oxononanoate synthase activity
C1A23_RS02265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1A23_RS02280	COG3306	glycosyltransferase involved in LPS biosynthesis
C1A23_RS02300	COG1561	YicC-like family, N-terminal region
C1A23_RS02305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1A23_RS02310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1A23_RS02320	COG0789	Transcriptional regulator
C1A23_RS02325	COG4251	negative regulation of phosphorylation
C1A23_RS02325	COG2203	Gaf domain
C1A23_RS02325	COG3706	GGDEF domain
C1A23_RS02325	COG5001	Diguanylate cyclase
C1A23_RS02330	COG3084	Protein conserved in bacteria
C1A23_RS02340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1A23_RS02345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1A23_RS02355	COG1335	isochorismatase
C1A23_RS02365	COG1683	Conserved Protein
C1A23_RS02370	COG0204	Acyl-transferase
C1A23_RS02375	COG0204	Acyl-transferase
C1A23_RS02380	COG0606	chelatase, subunit chli
C1A23_RS02395	COG3978	acetolactate synthase activity
C1A23_RS02405	COG0129	dihydroxy-acid dehydratase activity
C1A23_RS02425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1A23_RS02430	COG0254	rRNA binding
C1A23_RS02435	COG0702	epimerase
C1A23_RS02440	COG0281	malic enzyme
C1A23_RS02450	COG2205	protein histidine kinase activity
C1A23_RS02455	COG0745	RESPONSE REGULATOR receiver
C1A23_RS02460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1A23_RS02475	COG0366	Alpha amylase catalytic
C1A23_RS02490	COG0443	Heat shock 70 kDa protein
C1A23_RS02495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1A23_RS02500	COG3045	CreA protein
C1A23_RS02520	COG0174	glutamine synthetase
C1A23_RS02540	COG3842	ATPase activity
C1A23_RS02545	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1A23_RS02550	COG1177	transmembrane transport
C1A23_RS02555	COG2258	MOSC domain
C1A23_RS02570	COG2050	protein possibly involved in aromatic compounds catabolism
C1A23_RS02575	COG0514	ATP-dependent DNA helicase (RecQ)
C1A23_RS02585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C1A23_RS02595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1A23_RS02600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1A23_RS02610	COG2239	Acts as a magnesium transporter
C1A23_RS02615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1A23_RS02615	COG1648	precorrin-2 dehydrogenase activity
C1A23_RS02620	COG2116	formate transmembrane transporter activity
C1A23_RS02630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1A23_RS02635	COG0842	Transport permease protein
C1A23_RS02640	COG0842	Transport permease protein
C1A23_RS02645	COG1131	(ABC) transporter
C1A23_RS02650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A23_RS02660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C1A23_RS02665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C1A23_RS02675	COG0018	arginyl-trna synthetase
C1A23_RS02685	COG1595	DNA-templated transcription, initiation
C1A23_RS02690	COG3806	Anti-sigma factor
C1A23_RS02695	COG1968	undecaprenyl-diphosphatase activity
C1A23_RS02700	COG0667	Aldo Keto reductase
C1A23_RS02705	COG2017	converts alpha-aldose to the beta-anomer
C1A23_RS02710	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1A23_RS02720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1A23_RS02725	COG1609	Transcriptional regulator
C1A23_RS02730	COG3250	beta-galactosidase activity
C1A23_RS02780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1A23_RS02785	COG1288	antiporter activity
C1A23_RS02790	COG1438	arginine binding
C1A23_RS02795	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C1A23_RS02800	COG0540	Belongs to the ATCase OTCase family
C1A23_RS02820	COG0688	phosphatidylethanolamine metabolic process
C1A23_RS02830	COG3040	lipid binding
C1A23_RS02835	COG2207	Transcriptional regulator
C1A23_RS02840	COG1979	alcohol dehydrogenase
C1A23_RS02845	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C1A23_RS02850	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1A23_RS02860	COG3681	Belongs to the UPF0597 family
C1A23_RS02870	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1A23_RS02875	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1A23_RS02880	COG0564	pseudouridine synthase activity
C1A23_RS02890	COG0542	response to heat
C1A23_RS02895	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1A23_RS02905	COG2502	aspartate--ammonia ligase
C1A23_RS02910	COG1522	sequence-specific DNA binding
C1A23_RS02920	COG5413	integral membrane protein
C1A23_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
C1A23_RS02945	COG2205	protein histidine kinase activity
C1A23_RS02955	COG2204	response regulator
C1A23_RS02975	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C1A23_RS03005	COG0243	molybdopterin cofactor binding
C1A23_RS03010	COG3005	denitrification pathway
C1A23_RS03015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1A23_RS03035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1A23_RS03040	COG0569	domain protein
C1A23_RS03045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1A23_RS03070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1A23_RS03085	COG0250	Participates in transcription elongation, termination and antitermination
C1A23_RS03090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1A23_RS03095	COG0081	regulation of translation
C1A23_RS03100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1A23_RS03105	COG0222	ribosome binding
C1A23_RS03110	COG0085	RNA polymerase activity
C1A23_RS03115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1A23_RS03120	COG2964	Protein conserved in bacteria
C1A23_RS03125	COG0251	oxidation-reduction process
C1A23_RS03135	COG2923	Belongs to the DsrF TusC family
C1A23_RS03140	COG2168	tRNA wobble position uridine thiolation
C1A23_RS03145	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1A23_RS03150	COG0049	tRNA binding
C1A23_RS03155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1A23_RS03160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1A23_RS03165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1A23_RS03200	COG2252	PERMEase
C1A23_RS03205	COG2376	Dihydroxyacetone kinase
C1A23_RS03210	COG1461	Dihydroxyacetone kinase
C1A23_RS03225	COG3284	Transcriptional regulator
C1A23_RS03235	COG2957	Belongs to the agmatine deiminase family
C1A23_RS03240	COG4221	oxidoreductase activity
C1A23_RS03245	COG0628	permease
C1A23_RS03250	COG0494	nUDIX hydrolase
C1A23_RS03275	COG0753	catalase activity
C1A23_RS03280	COG1247	-acetyltransferase
C1A23_RS03300	COG3706	GGDEF domain
C1A23_RS03310	COG3842	ATPase activity
C1A23_RS03320	COG1175	transmembrane transport
C1A23_RS03350	COG0583	DNA-binding transcription factor activity
C1A23_RS03360	COG1741	Belongs to the pirin family
C1A23_RS03365	COG2259	Doxx family
C1A23_RS03370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1A23_RS03375	COG1074	ATP-dependent DNA helicase activity
C1A23_RS03380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1A23_RS03390	COG0346	lactoylglutathione lyase activity
C1A23_RS03440	COG2203	Gaf domain
C1A23_RS03440	COG5001	Diguanylate cyclase
C1A23_RS03440	COG3706	GGDEF domain
C1A23_RS03440	COG4251	negative regulation of phosphorylation
C1A23_RS03445	COG4771	TonB-dependent receptor
C1A23_RS03450	COG1278	Cold shock
C1A23_RS03490	COG2132	Multicopper oxidase
C1A23_RS03500	COG3039	Transposase
C1A23_RS03525	COG3039	Transposase
C1A23_RS03565	COG4974	Belongs to the 'phage' integrase family
C1A23_RS03570	COG0629	single-stranded DNA binding
C1A23_RS03575	COG2197	response regulator
C1A23_RS03580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1A23_RS03590	COG3047	cAMP biosynthetic process
C1A23_RS03620	COG3135	benzoate transporter
C1A23_RS03625	COG1396	sequence-specific DNA binding
C1A23_RS03655	COG2926	Belongs to the UPF0265 family
C1A23_RS03665	COG3028	Belongs to the UPF0307 family
C1A23_RS03670	COG0312	modulator of DNA gyrase
C1A23_RS03675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1A23_RS03680	COG5007	Belongs to the BolA IbaG family
C1A23_RS03690	COG2854	intermembrane phospholipid transfer
C1A23_RS03695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1A23_RS03700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1A23_RS03705	COG1127	ABC transporter
C1A23_RS03710	COG0517	IMP dehydrogenase activity
C1A23_RS03710	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1A23_RS03715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C1A23_RS03720	COG3117	lipopolysaccharide transmembrane transporter activity
C1A23_RS03725	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1A23_RS03730	COG1137	ATPase activity
C1A23_RS03735	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C1A23_RS03745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A23_RS03750	COG1660	Displays ATPase and GTPase activities
C1A23_RS03755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A23_RS03775	COG3964	amidohydrolase
C1A23_RS03805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1A23_RS03810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1A23_RS03820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1A23_RS03825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1A23_RS03830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1A23_RS03835	COG0723	plastoquinol--plastocyanin reductase activity
C1A23_RS03840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1A23_RS03845	COG2857	Cytochrome c1
C1A23_RS03850	COG0625	glutathione transferase activity
C1A23_RS03855	COG2969	positive regulation of protein catabolic process
C1A23_RS03860	COG2823	Periplasmic or secreted lipoprotein
C1A23_RS03865	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1A23_RS03870	COG0792	nuclease activity
C1A23_RS03875	COG3107	peptidoglycan biosynthetic process
C1A23_RS03880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1A23_RS03890	COG2001	Belongs to the MraZ family
C1A23_RS03895	COG0275	rRNA processing
C1A23_RS03900	COG3116	cell division
C1A23_RS03905	COG0768	penicillin binding
C1A23_RS03915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1A23_RS03920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1A23_RS03925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1A23_RS03930	COG0772	Belongs to the SEDS family
C1A23_RS03935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1A23_RS03940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1A23_RS03945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1A23_RS03950	COG0849	cell division
C1A23_RS03955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1A23_RS03960	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C1A23_RS03970	COG0653	protein targeting
C1A23_RS03980	COG0494	nUDIX hydrolase
C1A23_RS03985	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C1A23_RS03990	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C1A23_RS04005	COG1459	type II secretion system
C1A23_RS04010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1A23_RS04040	COG2186	Transcriptional regulator
C1A23_RS04045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1A23_RS04050	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1A23_RS04055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1A23_RS04065	COG0840	transmembrane signaling receptor activity
C1A23_RS04070	COG0840	transmembrane signaling receptor activity
C1A23_RS04075	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1A23_RS04080	COG1049	propionate catabolic process, 2-methylcitrate cycle
C1A23_RS04085	COG2200	EAL domain
C1A23_RS04095	COG1280	lysine exporter protein (LysE YggA)
C1A23_RS04105	COG0523	cobalamin synthesis protein
C1A23_RS04110	COG0477	Major facilitator Superfamily
C1A23_RS04125	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1A23_RS04130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C1A23_RS04170	COG3314	Sporulation integral membrane protein YlbJ
C1A23_RS04175	COG0784	Response regulator, receiver
C1A23_RS04175	COG0835	chemotaxis
C1A23_RS04180	COG1028	Short-chain dehydrogenase reductase Sdr
C1A23_RS04185	COG1444	tRNA N-acetyltransferase activity
C1A23_RS04210	COG1803	Methylglyoxal synthase
C1A23_RS04225	COG0252	asparaginase activity
C1A23_RS04245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1A23_RS04245	COG1263	PTS System
C1A23_RS04250	COG0366	Alpha amylase catalytic
C1A23_RS04255	COG0110	maltose O-acetyltransferase activity
C1A23_RS04260	COG1522	sequence-specific DNA binding
C1A23_RS04265	COG5006	permease, DMT superfamily
C1A23_RS04275	COG1012	belongs to the aldehyde dehydrogenase family
C1A23_RS04280	COG1177	transmembrane transport
C1A23_RS04285	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1A23_RS04290	COG3842	ATPase activity
C1A23_RS04295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C1A23_RS04300	COG0583	DNA-binding transcription factor activity
C1A23_RS04345	COG0297	glycogen (starch) synthase activity
C1A23_RS04350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1A23_RS04355	COG2813	Specifically methylates the guanine in position
C1A23_RS04360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1A23_RS04365	COG3706	GGDEF domain
C1A23_RS04365	COG2203	Gaf domain
C1A23_RS04365	COG5001	Diguanylate cyclase
C1A23_RS04365	COG4251	negative regulation of phosphorylation
C1A23_RS04375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1A23_RS04385	COG2995	paraquat-inducible protein a
C1A23_RS04390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1A23_RS04390	COG3008	intermembrane lipid transfer
C1A23_RS04395	COG3009	Protein conserved in bacteria
C1A23_RS04400	COG2885	chlorophyll binding
C1A23_RS04400	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C1A23_RS04410	COG3240	lipase activity
C1A23_RS04415	COG3111	PFAM Bacterial OB fold (BOF) protein
C1A23_RS04425	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C1A23_RS04430	COG1194	a g-specific adenine glycosylase
C1A23_RS04440	COG3267	Type II secretory pathway component ExeA
C1A23_RS04440	COG3409	Peptidoglycan-binding domain 1 protein
C1A23_RS04445	COG0617	tRNA 3'-terminal CCA addition
C1A23_RS04460	COG1346	cytolysis
C1A23_RS04465	COG1380	Effector of murein hydrolase LrgA
C1A23_RS04470	COG0583	DNA-binding transcription factor activity
C1A23_RS04500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1A23_RS04505	COG0306	phosphate transporter
C1A23_RS04510	COG1392	Phosphate transport regulator
C1A23_RS04525	COG1560	Kdo2-lipid A biosynthetic process
C1A23_RS04530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1A23_RS04530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1A23_RS04535	COG1538	Outer membrane efflux protein
C1A23_RS04540	COG0494	nUDIX hydrolase
C1A23_RS04545	COG3151	Protein conserved in bacteria
C1A23_RS04555	COG3150	esterase
C1A23_RS04560	COG1051	belongs to the nudix hydrolase family
C1A23_RS04575	COG1566	PFAM secretion protein HlyD family protein
C1A23_RS04580	COG1289	transmembrane transporter activity
C1A23_RS04600	COG0583	DNA-binding transcription factor activity
C1A23_RS04640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1A23_RS04660	COG0204	Acyl-transferase
C1A23_RS04665	COG1842	Phage shock protein A
C1A23_RS04680	COG2827	Endonuclease containing a URI domain
C1A23_RS04690	COG2962	Rard protein
C1A23_RS04695	COG1573	uracil-dna glycosylase
C1A23_RS04700	COG0697	spore germination
C1A23_RS04705	COG0583	DNA-binding transcription factor activity
C1A23_RS04710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1A23_RS04715	COG1121	(ABC) transporter
C1A23_RS04720	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1A23_RS04740	COG0739	heme binding
C1A23_RS04755	COG3068	Protein conserved in bacteria
C1A23_RS04775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C1A23_RS04780	COG1546	Belongs to the CinA family
C1A23_RS04785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1A23_RS04795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1A23_RS04800	COG0527	aspartate kinase activity
C1A23_RS04805	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C1A23_RS04840	COG1686	Belongs to the peptidase S11 family
C1A23_RS04845	COG0586	Pfam SNARE associated Golgi protein
C1A23_RS04850	COG1253	flavin adenine dinucleotide binding
C1A23_RS04855	COG0525	valine-tRNA ligase activity
C1A23_RS04860	COG2927	DNA polymerase III (CHI subunit)
C1A23_RS04865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1A23_RS04870	COG0795	lipopolysaccharide-transporting ATPase activity
C1A23_RS04875	COG0795	lipopolysaccharide-transporting ATPase activity
C1A23_RS04890	COG0582	viral genome integration into host DNA
C1A23_RS04905	COG3561	AntA/AntB antirepressor
C1A23_RS04945	COG0004	ammonium transporteR
C1A23_RS04950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1A23_RS04960	COG2165	general secretion pathway protein
C1A23_RS04965	COG0084	hydrolase, TatD family'
C1A23_RS04970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1A23_RS04980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1A23_RS04985	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C1A23_RS04990	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C1A23_RS04995	COG0813	purine-nucleoside phosphorylase activity
C1A23_RS05000	COG5002	protein histidine kinase activity
C1A23_RS05000	COG3447	MASE1 domain protein
C1A23_RS05000	COG5001	Diguanylate cyclase
C1A23_RS05010	COG0560	Phosphoserine phosphatase
C1A23_RS05035	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C1A23_RS05040	COG0776	regulation of translation
C1A23_RS05055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1A23_RS05060	COG0735	belongs to the Fur family
C1A23_RS05085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C1A23_RS05090	COG0513	Belongs to the DEAD box helicase family
C1A23_RS05095	COG3022	response to hydroperoxide
C1A23_RS05110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1A23_RS05115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C1A23_RS05120	COG0762	integral membrane protein
C1A23_RS05125	COG1872	DUF167
C1A23_RS05140	COG4166	transmembrane transport
C1A23_RS05160	COG1024	Enoyl-CoA hydratase
C1A23_RS05175	COG4221	oxidoreductase activity
C1A23_RS05180	COG0442	prolyl-tRNA aminoacylation
C1A23_RS05185	COG0840	transmembrane signaling receptor activity
C1A23_RS05190	COG0632	four-way junction helicase activity
C1A23_RS05195	COG2255	four-way junction helicase activity
C1A23_RS05200	COG1271	oxidase subunit
C1A23_RS05205	COG1294	oxidase, subunit
C1A23_RS05210	COG4890	Cyd operon protein YbgT
C1A23_RS05215	COG3790	cyd operon protein YbgE
C1A23_RS05220	COG0824	Thioesterase
C1A23_RS05225	COG0811	peptide transport
C1A23_RS05240	COG0823	Involved in the tonB-independent uptake of proteins
C1A23_RS05245	COG2885	chlorophyll binding
C1A23_RS05250	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C1A23_RS05325	COG0840	transmembrane signaling receptor activity
C1A23_RS05330	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1A23_RS05335	COG0676	glucose-6-phosphate 1-epimerase activity
C1A23_RS05340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1A23_RS05345	COG1640	4-alpha-glucanotransferase
C1A23_RS05350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1A23_RS05370	COG1051	belongs to the nudix hydrolase family
C1A23_RS05375	COG2130	NADP-dependent
C1A23_RS05380	COG1764	response to oxidative stress
C1A23_RS05385	COG1846	Transcriptional regulator
C1A23_RS05420	COG0561	phosphatase activity
C1A23_RS05435	COG0733	neurotransmitter:sodium symporter activity
C1A23_RS05445	COG0733	neurotransmitter:sodium symporter activity
C1A23_RS05470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1A23_RS05480	COG1794	racemase activity, acting on amino acids and derivatives
C1A23_RS05495	COG2731	YhcH YjgK YiaL family protein
C1A23_RS05505	COG0668	transmembrane transport
C1A23_RS05515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1A23_RS05545	COG0583	DNA-binding transcription factor activity
C1A23_RS05550	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1A23_RS05560	COG0488	(ABC) transporter
C1A23_RS05565	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C1A23_RS05565	COG0517	IMP dehydrogenase activity
C1A23_RS05570	COG1585	Membrane protein implicated in regulation of membrane protease activity
C1A23_RS05575	COG0330	HflC and HflK could
C1A23_RS05580	COG1648	precorrin-2 dehydrogenase activity
C1A23_RS05580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1A23_RS05585	COG0175	sulfate reduction
C1A23_RS05590	COG2895	sulfate adenylyltransferase (ATP) activity
C1A23_RS05595	COG3273	potassium ion transport
C1A23_RS05595	COG0471	metal ion transport
C1A23_RS05600	COG0529	Catalyzes the synthesis of activated sulfate
C1A23_RS05625	COG0840	transmembrane signaling receptor activity
C1A23_RS05645	COG1136	(ABC) transporter
C1A23_RS05660	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C1A23_RS05680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1A23_RS05685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1A23_RS05690	COG0163	prenyltransferase activity
C1A23_RS05705	COG1131	(ABC) transporter
C1A23_RS05710	COG0842	Transport permease protein
C1A23_RS05715	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C1A23_RS05720	COG1924	4 iron, 4 sulfur cluster binding
C1A23_RS05740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1A23_RS05745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1A23_RS05760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1A23_RS05765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1A23_RS05770	COG1489	DNA binding
C1A23_RS05780	COG1643	Atp-dependent helicase
C1A23_RS05785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1A23_RS05790	COG0346	lactoylglutathione lyase activity
C1A23_RS05800	COG2076	Multidrug Resistance protein
C1A23_RS05810	COG3437	response regulator, receiver
C1A23_RS05810	COG0784	Response regulator, receiver
C1A23_RS05820	COG0671	phosphoesterase, PA-phosphatase related
C1A23_RS05835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1A23_RS05840	COG0038	chloride channel
C1A23_RS05850	COG0316	Belongs to the HesB IscA family
C1A23_RS05880	COG2816	NAD+ diphosphatase activity
C1A23_RS05885	COG2205	protein histidine kinase activity
C1A23_RS05890	COG0745	RESPONSE REGULATOR receiver
C1A23_RS05895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A23_RS05900	COG1136	(ABC) transporter
C1A23_RS05900	COG0577	efflux transmembrane transporter activity
C1A23_RS05905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A23_RS05910	COG1126	abc transporter atp-binding protein
C1A23_RS05915	COG0765	amino acid transport
C1A23_RS05920	COG0765	amino acid transport
C1A23_RS05925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1A23_RS05930	COG1505	serine-type exopeptidase activity
C1A23_RS05950	COG1028	Short-chain dehydrogenase reductase Sdr
C1A23_RS05955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1A23_RS05970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1A23_RS05975	COG4991	sh3 domain protein
C1A23_RS05990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1A23_RS05995	COG1940	carbohydrate kinase activity
C1A23_RS06000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1A23_RS06005	COG0126	phosphoglycerate kinase activity
C1A23_RS06015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1A23_RS06025	COG4232	protein-disulfide reductase activity
C1A23_RS06055	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C1A23_RS06065	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1A23_RS06070	COG1595	DNA-templated transcription, initiation
C1A23_RS06075	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C1A23_RS06090	COG0481	GTPase activity
C1A23_RS06095	COG0681	Belongs to the peptidase S26 family
C1A23_RS06100	COG0571	ribonuclease III activity
C1A23_RS06110	COG1381	Involved in DNA repair and RecF pathway recombination
C1A23_RS06115	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C1A23_RS06130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1A23_RS06135	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A23_RS06140	COG3716	PTS system mannose fructose sorbose family IID component
C1A23_RS06150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1A23_RS06155	COG2222	sugar isomerase
C1A23_RS06165	COG1349	DNA-binding transcription factor activity
C1A23_RS06170	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1A23_RS06175	COG4807	Protein conserved in bacteria
C1A23_RS06185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1A23_RS06190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1A23_RS06195	COG3956	TIGRFAM MazG family protein
C1A23_RS06200	COG0504	CTP synthase activity
C1A23_RS06205	COG0148	phosphopyruvate hydratase activity
C1A23_RS06210	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C1A23_RS06215	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1A23_RS06225	COG0585	pseudouridine synthase activity
C1A23_RS06230	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C1A23_RS06235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1A23_RS06240	COG1238	metal cluster binding
C1A23_RS06255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1A23_RS06260	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C1A23_RS06265	COG1610	YqeY-like protein
C1A23_RS06270	COG0358	DNA primase activity
C1A23_RS06275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1A23_RS06310	COG1484	DNA-dependent DNA replication
C1A23_RS06315	COG4584	PFAM Integrase catalytic
C1A23_RS06345	COG0151	Belongs to the GarS family
C1A23_RS06350	COG0138	bifunctional purine biosynthesis protein purh
C1A23_RS06360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C1A23_RS06365	COG3036	rescue of stalled ribosome
C1A23_RS06370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1A23_RS06375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1A23_RS06385	COG0673	inositol 2-dehydrogenase activity
C1A23_RS06395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1A23_RS06400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1A23_RS06415	COG0477	Major facilitator Superfamily
C1A23_RS06425	COG5433	transposase activity
C1A23_RS06435	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1A23_RS06440	COG1027	Aspartate ammonia-lyase
C1A23_RS06445	COG3030	protein affecting phage T7 exclusion by the F plasmid
C1A23_RS06450	COG0534	Mate efflux family protein
C1A23_RS06455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1A23_RS06460	COG0459	protein refolding
C1A23_RS06470	COG3300	MHYT domain
C1A23_RS06470	COG5001	Diguanylate cyclase
C1A23_RS06480	COG0564	pseudouridine synthase activity
C1A23_RS06485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1A23_RS06515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1A23_RS06525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1A23_RS06535	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C1A23_RS06540	COG1178	ABC-type Fe3 transport system permease component
C1A23_RS06560	COG0066	3-isopropylmalate dehydratase activity
C1A23_RS06565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1A23_RS06570	COG0473	3-isopropylmalate dehydrogenase activity
C1A23_RS06575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1A23_RS06585	COG0671	phosphoesterase, PA-phosphatase related
C1A23_RS06590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1A23_RS06600	COG0028	Belongs to the TPP enzyme family
C1A23_RS06610	COG0280	phosphate acetyltransferase
C1A23_RS06610	COG0857	belongs to the CobB CobQ family
C1A23_RS06615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1A23_RS06625	COG3013	Belongs to the UPF0304 family
C1A23_RS06630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1A23_RS06635	COG2716	regulation of RNA biosynthetic process
C1A23_RS06645	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C1A23_RS06650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1A23_RS06665	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C1A23_RS06685	COG0784	Response regulator, receiver
C1A23_RS06685	COG5002	protein histidine kinase activity
C1A23_RS06685	COG2198	Histidine kinase
C1A23_RS06710	COG0840	transmembrane signaling receptor activity
C1A23_RS06720	COG1464	Belongs to the NlpA lipoprotein family
C1A23_RS06725	COG2011	ABC-type metal ion transport system permease component
C1A23_RS06730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1A23_RS06745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1A23_RS06750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1A23_RS06750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1A23_RS06755	COG0802	atpase or kinase
C1A23_RS06765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C1A23_RS06770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1A23_RS06775	COG1923	regulation of RNA biosynthetic process
C1A23_RS06780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1A23_RS06785	COG0330	HflC and HflK could
C1A23_RS06790	COG0330	HflC and HflK could
C1A23_RS06795	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C1A23_RS06800	COG0142	geranyltranstransferase activity
C1A23_RS06805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1A23_RS06810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1A23_RS06815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1A23_RS06820	COG3314	Sporulation integral membrane protein YlbJ
C1A23_RS06825	COG0318	PFAM AMP-dependent synthetase and ligase
C1A23_RS06840	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1A23_RS06845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1A23_RS06855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1A23_RS06860	COG2967	ApaG domain
C1A23_RS06865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1A23_RS06870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1A23_RS06880	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1A23_RS06885	COG3178	'Phosphotransferase
C1A23_RS06890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1A23_RS06895	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1A23_RS06900	COG2252	PERMEase
C1A23_RS06910	COG0488	(ABC) transporter
C1A23_RS06930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1A23_RS06935	COG0741	lytic transglycosylase activity
C1A23_RS06955	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C1A23_RS06960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1A23_RS06965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C1A23_RS06990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1A23_RS07000	COG3721	Heme iron utilization protein
C1A23_RS07005	COG0748	coenzyme F420 binding
C1A23_RS07025	COG4771	TonB-dependent receptor
C1A23_RS07035	COG2814	Major facilitator Superfamily
C1A23_RS07040	COG3655	Transcriptional regulator
C1A23_RS07050	COG2202	Pas domain
C1A23_RS07050	COG2205	protein histidine kinase activity
C1A23_RS07065	COG3397	chitin binding
C1A23_RS07070	COG2226	methyltransferase
C1A23_RS07080	COG1765	OsmC-like protein
C1A23_RS07095	COG3954	Phosphoribulokinase
C1A23_RS07100	COG2076	Multidrug Resistance protein
C1A23_RS07105	COG2076	Multidrug Resistance protein
C1A23_RS07110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1A23_RS07115	COG0726	polysaccharide deacetylase
C1A23_RS07120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1A23_RS07120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1A23_RS07125	COG0463	Glycosyl transferase, family 2
C1A23_RS07130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1A23_RS07140	COG3089	Belongs to the UPF0270 family
C1A23_RS07145	COG2203	Gaf domain
C1A23_RS07145	COG3706	GGDEF domain
C1A23_RS07145	COG4251	negative regulation of phosphorylation
C1A23_RS07145	COG5001	Diguanylate cyclase
C1A23_RS07150	COG0429	hydrolase of the alpha beta-hydrolase fold
C1A23_RS07155	COG0835	chemotaxis
C1A23_RS07155	COG0784	Response regulator, receiver
C1A23_RS07165	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C1A23_RS07170	COG1047	Peptidyl-prolyl cis-trans
C1A23_RS07185	COG0545	Peptidyl-prolyl cis-trans isomerase
C1A23_RS07190	COG2204	response regulator
C1A23_RS07210	COG0737	Belongs to the 5'-nucleotidase family
C1A23_RS07220	COG2200	EAL domain
C1A23_RS07235	COG0305	Participates in initiation and elongation during chromosome replication
C1A23_RS07245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1A23_RS07255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1A23_RS07260	COG0826	peptidase U32
C1A23_RS07265	COG2199	diguanylate cyclase activity
C1A23_RS07265	COG2203	Gaf domain
C1A23_RS07265	COG2200	EAL domain
C1A23_RS07285	COG3188	usher protein
C1A23_RS07295	COG3039	Transposase
C1A23_RS07310	COG2197	response regulator
C1A23_RS07340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1A23_RS07345	COG2201	protein-glutamate methylesterase activity
C1A23_RS07350	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C1A23_RS07375	COG0835	chemotaxis
C1A23_RS07385	COG0643	Histidine kinase
C1A23_RS07385	COG2198	Histidine kinase
C1A23_RS07400	COG0840	transmembrane signaling receptor activity
C1A23_RS07405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1A23_RS07415	COG1280	lysine exporter protein (LysE YggA)
C1A23_RS07420	COG0826	peptidase U32
C1A23_RS07445	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C1A23_RS07470	COG0300	oxidoreductase activity
C1A23_RS07525	COG0840	transmembrane signaling receptor activity
C1A23_RS07565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1A23_RS07575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1A23_RS07580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A23_RS07650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1A23_RS07680	COG1484	DNA-dependent DNA replication
C1A23_RS07685	COG4584	PFAM Integrase catalytic
C1A23_RS07700	COG4133	protoheme IX ABC transporter activity
C1A23_RS07725	COG2003	Belongs to the UPF0758 family
C1A23_RS07770	COG5377	YqaJ viral recombinase family
C1A23_RS07800	COG0077	Prephenate dehydratase
C1A23_RS07800	COG1605	Chorismate mutase
C1A23_RS07830	COG3272	Protein of unknown function (DUF1722)
C1A23_RS07835	COG0789	Transcriptional regulator
C1A23_RS07840	COG0415	Belongs to the DNA photolyase family
C1A23_RS07850	COG4221	oxidoreductase activity
C1A23_RS07865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1A23_RS07890	COG0783	Belongs to the Dps family
C1A23_RS07895	COG1151	hydroxylamine reductase activity
C1A23_RS07905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1A23_RS07910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1A23_RS07910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1A23_RS07930	COG2771	luxR family
C1A23_RS07985	COG1484	DNA-dependent DNA replication
C1A23_RS07990	COG4584	PFAM Integrase catalytic
C1A23_RS08000	COG0693	protein deglycase activity
C1A23_RS08005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1A23_RS08010	COG1666	GTP binding
C1A23_RS08015	COG3248	Nucleoside-binding outer membrane protein
C1A23_RS08020	COG2211	Major facilitator Superfamily
C1A23_RS08030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1A23_RS08040	COG2813	Specifically methylates the guanine in position
C1A23_RS08045	COG0271	Belongs to the BolA IbaG family
C1A23_RS08050	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1A23_RS08055	COG1805	sodium ion transport
C1A23_RS08060	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1A23_RS08065	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1A23_RS08070	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1A23_RS08075	COG2871	sodium ion transport
C1A23_RS08080	COG1477	protein flavinylation
C1A23_RS08095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1A23_RS08100	COG0840	transmembrane signaling receptor activity
C1A23_RS08105	COG0583	DNA-binding transcription factor activity
C1A23_RS08115	COG2363	Small membrane protein
C1A23_RS08120	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C1A23_RS08130	COG0473	3-isopropylmalate dehydrogenase activity
C1A23_RS08135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1A23_RS08140	COG1611	Belongs to the LOG family
C1A23_RS08155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1A23_RS08155	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C1A23_RS08165	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C1A23_RS08190	COG3098	single-species biofilm formation
C1A23_RS08195	COG0564	pseudouridine synthase activity
C1A23_RS08205	COG4580	involved in the transport of maltose and maltodextrins
C1A23_RS08215	COG1263	PTS System
C1A23_RS08215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1A23_RS08225	COG2171	N-acyltransferase activity
C1A23_RS08230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1A23_RS08235	COG0024	Methionine aminopeptidase
C1A23_RS08240	COG0052	Belongs to the universal ribosomal protein uS2 family
C1A23_RS08245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1A23_RS08250	COG0528	UMP kinase activity
C1A23_RS08255	COG0233	cytoplasmic translational termination
C1A23_RS08260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1A23_RS08265	COG0575	Belongs to the CDS family
C1A23_RS08270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1A23_RS08275	COG0750	zinc metalloprotease
C1A23_RS08290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1A23_RS08295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1A23_RS08300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1A23_RS08305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1A23_RS08310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1A23_RS08320	COG0825	malonyl-CoA metabolic process
C1A23_RS08325	COG3710	Transcriptional regulator
C1A23_RS08330	COG0531	amino acid
C1A23_RS08335	COG1982	Orn Lys Arg decarboxylase major
C1A23_RS08340	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C1A23_RS08355	COG0814	amino acid
C1A23_RS08370	COG1073	alpha beta
C1A23_RS08375	COG1073	alpha beta
C1A23_RS08385	COG0531	amino acid
C1A23_RS08395	COG0488	(ABC) transporter
C1A23_RS08405	COG3590	peptidase
C1A23_RS08415	COG3706	GGDEF domain
C1A23_RS08450	COG0366	Alpha amylase catalytic
C1A23_RS08465	COG0463	Glycosyl transferase, family 2
C1A23_RS08480	COG2989	Protein conserved in bacteria
C1A23_RS08485	COG3108	Peptidase M15
C1A23_RS08495	COG2860	membrane
C1A23_RS08505	COG1196	nuclear chromosome segregation
C1A23_RS08510	COG3115	cell septum assembly
C1A23_RS08515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1A23_RS08525	COG1328	CTP reductase activity
C1A23_RS08530	COG0602	queuosine metabolic process
C1A23_RS08560	COG1566	PFAM secretion protein HlyD family protein
C1A23_RS08565	COG1846	Transcriptional regulator
C1A23_RS08580	COG0281	malic enzyme
C1A23_RS08585	COG3290	protein histidine kinase activity
C1A23_RS08590	COG4565	transcriptional regulatory protein
C1A23_RS08595	COG0697	spore germination
C1A23_RS08610	COG3284	Transcriptional regulator
C1A23_RS08615	COG1960	acyl-CoA dehydrogenase activity
C1A23_RS08620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1A23_RS08625	COG0346	lactoylglutathione lyase activity
C1A23_RS08630	COG0745	RESPONSE REGULATOR receiver
C1A23_RS08635	COG5002	protein histidine kinase activity
C1A23_RS08660	COG3142	Participates in the control of copper homeostasis
C1A23_RS08665	COG0545	Peptidyl-prolyl cis-trans isomerase
C1A23_RS08670	COG1131	(ABC) transporter
C1A23_RS08690	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1A23_RS08710	COG0019	diaminopimelate decarboxylase activity
C1A23_RS08715	COG1115	amino acid carrier protein
C1A23_RS08720	COG0095	Lipoate-protein ligase
C1A23_RS08740	COG0534	Mate efflux family protein
C1A23_RS08750	COG0281	malic enzyme
C1A23_RS08765	COG5433	transposase activity
C1A23_RS08785	COG0733	neurotransmitter:sodium symporter activity
C1A23_RS08790	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1A23_RS08800	COG1566	PFAM secretion protein HlyD family protein
C1A23_RS08805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1A23_RS08815	COG1032	radical SAM domain protein
C1A23_RS08820	COG2801	Transposase and inactivated derivatives
C1A23_RS08845	COG0673	inositol 2-dehydrogenase activity
C1A23_RS08855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1A23_RS08860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1A23_RS08865	COG1196	nuclear chromosome segregation
C1A23_RS08865	COG0741	lytic transglycosylase activity
C1A23_RS08865	COG0739	heme binding
C1A23_RS08870	COG0366	Alpha amylase catalytic
C1A23_RS08890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1A23_RS08900	COG0788	formyltetrahydrofolate deformylase activity
C1A23_RS08905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1A23_RS08915	COG3118	belongs to the thioredoxin family
C1A23_RS08925	COG0791	NLP P60 protein
C1A23_RS08930	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C1A23_RS08945	COG1376	ErfK ybiS ycfS ynhG family protein
C1A23_RS08945	COG1388	LysM domain
C1A23_RS08955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1A23_RS08960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A23_RS08965	COG0745	RESPONSE REGULATOR receiver
C1A23_RS08970	COG5002	protein histidine kinase activity
C1A23_RS08990	COG4869	propanediol catabolic process
C1A23_RS09000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1A23_RS09005	COG1882	Formate acetyltransferase
C1A23_RS09010	COG1012	belongs to the aldehyde dehydrogenase family
C1A23_RS09010	COG1454	alcohol dehydrogenase
C1A23_RS09020	COG1012	belongs to the aldehyde dehydrogenase family
C1A23_RS09020	COG1454	alcohol dehydrogenase
C1A23_RS09055	COG0583	DNA-binding transcription factor activity
C1A23_RS09060	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1A23_RS09065	COG0243	molybdopterin cofactor binding
C1A23_RS09075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1A23_RS09085	COG1960	acyl-CoA dehydrogenase activity
C1A23_RS09090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1A23_RS09100	COG0469	pyruvate kinase activity
C1A23_RS09105	COG1737	Transcriptional regulator
C1A23_RS09125	COG2274	protein secretion by the type I secretion system
C1A23_RS09135	COG2274	protein secretion by the type I secretion system
C1A23_RS09160	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
C1A23_RS09160	COG3064	Membrane
C1A23_RS09160	COG1073	alpha beta
C1A23_RS09170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1A23_RS09180	COG1028	Short-chain dehydrogenase reductase Sdr
C1A23_RS09190	COG1414	Transcriptional regulator
C1A23_RS09195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1A23_RS09200	COG0800	Aldolase
C1A23_RS09205	COG2731	YhcH YjgK YiaL family protein
C1A23_RS09225	COG1677	Flagellar hook-basal body complex protein FliE
C1A23_RS09235	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1A23_RS09290	COG1684	flagellar biosynthetic protein fliR
C1A23_RS09300	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1A23_RS09325	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C1A23_RS09330	COG0784	Response regulator, receiver
C1A23_RS09330	COG0643	Histidine kinase
C1A23_RS09330	COG2198	Histidine kinase
C1A23_RS09335	COG2201	protein-glutamate methylesterase activity
C1A23_RS09340	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1A23_RS09345	COG1360	Flagellar Motor Protein
C1A23_RS09350	COG1192	Involved in chromosome partitioning
C1A23_RS09360	COG0835	chemotaxis
C1A23_RS09375	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1A23_RS09380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1A23_RS09385	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1A23_RS09390	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C1A23_RS09395	COG1138	Cytochrome C-type biogenesis protein
C1A23_RS09400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1A23_RS09405	COG3088	subunit of a heme lyase
C1A23_RS09405	COG4235	cytochrome complex assembly
C1A23_RS09410	COG3088	subunit of a heme lyase
C1A23_RS09410	COG4235	cytochrome complex assembly
C1A23_RS09425	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C1A23_RS09430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1A23_RS09430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1A23_RS09445	COG0259	pyridoxamine-phosphate oxidase activity
C1A23_RS09450	COG0625	glutathione transferase activity
C1A23_RS09460	COG3153	acetyltransferase
C1A23_RS09465	COG2850	peptidyl-arginine hydroxylation
C1A23_RS09470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1A23_RS09475	COG2915	High frequency lysogenization protein hflD homolog
C1A23_RS09480	COG0482	sulfurtransferase activity
C1A23_RS09490	COG1187	pseudouridine synthase activity
C1A23_RS09500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1A23_RS09510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1A23_RS09510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A23_RS09510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1A23_RS09525	COG3385	transposase activity
C1A23_RS09535	COG0456	acetyltransferase
C1A23_RS09545	COG0789	Transcriptional regulator
C1A23_RS09550	COG1902	pentaerythritol trinitrate reductase activity
C1A23_RS09550	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1A23_RS09555	COG1609	Transcriptional regulator
C1A23_RS09560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1A23_RS09560	COG1263	PTS System
C1A23_RS09565	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1A23_RS09580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1A23_RS09600	COG2207	Transcriptional regulator
C1A23_RS09605	COG0538	isocitrate dehydrogenase activity
C1A23_RS09615	COG3048	D-serine ammonia-lyase activity
C1A23_RS09625	COG0583	DNA-binding transcription factor activity
C1A23_RS09665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1A23_RS09670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A23_RS09750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1A23_RS09760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1A23_RS09770	COG1715	Restriction endonuclease
C1A23_RS09820	COG2003	Belongs to the UPF0758 family
C1A23_RS09855	COG5377	YqaJ viral recombinase family
C1A23_RS09870	COG3311	Transcriptional regulator
C1A23_RS09875	COG4983	Phage plasmid primase, P4 family domain protein
C1A23_RS09890	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1A23_RS09895	COG0582	viral genome integration into host DNA
C1A23_RS09905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1A23_RS09910	COG2867	negative regulation of translational initiation
C1A23_RS09915	COG2914	Belongs to the UPF0125 (RnfH) family
C1A23_RS09920	COG0702	epimerase
C1A23_RS09925	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1A23_RS09930	COG1454	alcohol dehydrogenase
C1A23_RS09940	COG0564	pseudouridine synthase activity
C1A23_RS09970	COG1280	lysine exporter protein (LysE YggA)
C1A23_RS09980	COG3263	regulation of cellular component size
C1A23_RS09990	COG3263	regulation of cellular component size
C1A23_RS10000	COG1876	peptidase activity
C1A23_RS10005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1A23_RS10010	COG1393	Belongs to the ArsC family
C1A23_RS10015	COG0583	DNA-binding transcription factor activity
C1A23_RS10025	COG3069	C4-dicarboxylate transmembrane transporter activity
C1A23_RS10040	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C1A23_RS10045	COG0017	Asparaginyl-tRNA synthetase
C1A23_RS10065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1A23_RS10070	COG0156	8-amino-7-oxononanoate synthase activity
C1A23_RS10075	COG2226	methyltransferase
C1A23_RS10075	COG1073	alpha beta
C1A23_RS10080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C1A23_RS10085	COG0501	Belongs to the peptidase M48B family
C1A23_RS10095	COG3217	Mosc domain protein beta barrel domain protein
C1A23_RS10095	COG0633	Ferredoxin
C1A23_RS10095	COG0633	Ferredoxin
C1A23_RS10095	COG3217	Mosc domain protein beta barrel domain protein
C1A23_RS10105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1A23_RS10105	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1A23_RS10105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1A23_RS10105	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1A23_RS10130	COG0534	Mate efflux family protein
C1A23_RS10170	COG1309	transcriptional regulator
C1A23_RS10185	COG0791	NLP P60 protein
C1A23_RS10195	COG0583	DNA-binding transcription factor activity
C1A23_RS10200	COG0450	alkyl hydroperoxide reductase
C1A23_RS10220	COG0500	methyltransferase
C1A23_RS10225	COG4106	trans-aconitate 2-methyltransferase activity
C1A23_RS10230	COG1801	Protein of unknown function DUF72
C1A23_RS10240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1A23_RS10245	COG0217	transcriptional regulatory protein
C1A23_RS10250	COG2194	sulfuric ester hydrolase activity
C1A23_RS10255	COG1940	carbohydrate kinase activity
C1A23_RS10255	COG1846	Transcriptional regulator
C1A23_RS10260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1A23_RS10265	COG0363	glucosamine-6-phosphate deaminase activity
C1A23_RS10270	COG1263	PTS System
C1A23_RS10270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1A23_RS10270	COG2190	(PTS) system
C1A23_RS10280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1A23_RS10285	COG0735	belongs to the Fur family
C1A23_RS10295	COG0716	FMN binding
C1A23_RS10310	COG0596	Alpha beta hydrolase
C1A23_RS10315	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C1A23_RS10320	COG0033	Phosphoglucomutase
C1A23_RS10330	COG1846	Transcriptional regulator
C1A23_RS10345	COG2951	lytic endotransglycosylase activity
C1A23_RS10350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1A23_RS10355	COG4136	ATPase activity
C1A23_RS10360	COG4135	transport system, permease component
C1A23_RS10365	COG4134	Bacterial extracellular solute-binding protein
C1A23_RS10375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1A23_RS10385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1A23_RS10390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1A23_RS10400	COG0729	surface antigen
C1A23_RS10405	COG2911	Protein conserved in bacteria
C1A23_RS10425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1A23_RS10435	COG0741	lytic transglycosylase activity
C1A23_RS10450	COG1607	acyl-coa hydrolase
C1A23_RS10460	COG3021	interspecies interaction between organisms
C1A23_RS10465	COG1388	LysM domain
C1A23_RS10465	COG0741	lytic transglycosylase activity
C1A23_RS10470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1A23_RS10475	COG2226	methyltransferase
C1A23_RS10480	COG0328	RNA-DNA hybrid ribonuclease activity
C1A23_RS10495	COG3437	response regulator, receiver
C1A23_RS10495	COG0784	Response regulator, receiver
C1A23_RS10500	COG1960	acyl-CoA dehydrogenase activity
C1A23_RS10505	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1A23_RS10510	COG0121	glutamine amidotransferase
C1A23_RS10540	COG2197	response regulator
C1A23_RS10545	COG3850	Histidine kinase
C1A23_RS10550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1A23_RS10555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1A23_RS10555	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1A23_RS10565	COG0243	molybdopterin cofactor binding
C1A23_RS10570	COG0437	4 iron, 4 sulfur cluster binding
C1A23_RS10575	COG0348	domain, Protein
C1A23_RS10585	COG3005	denitrification pathway
C1A23_RS10590	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1A23_RS10595	COG0315	cyclic pyranopterin monophosphate synthase activity
C1A23_RS10600	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1A23_RS10605	COG0314	molybdopterin synthase activity
C1A23_RS10620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C1A23_RS10625	COG2267	carboxylic ester hydrolase activity
C1A23_RS10630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1A23_RS10640	COG0302	gtp cyclohydrolase
C1A23_RS10645	COG0840	transmembrane signaling receptor activity
C1A23_RS10650	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1A23_RS10655	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C1A23_RS10665	COG0583	DNA-binding transcription factor activity
C1A23_RS10695	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1A23_RS10715	COG1166	arginine decarboxylase activity
C1A23_RS10735	COG0814	amino acid
C1A23_RS10745	COG3681	Belongs to the UPF0597 family
C1A23_RS10750	COG2964	Protein conserved in bacteria
C1A23_RS10760	COG1403	HNH endonuclease
C1A23_RS10770	COG0346	lactoylglutathione lyase activity
C1A23_RS10790	COG1187	pseudouridine synthase activity
C1A23_RS10800	COG2807	transmembrane transport
C1A23_RS10810	COG0583	DNA-binding transcription factor activity
C1A23_RS10815	COG2271	Major facilitator Superfamily
C1A23_RS10845	COG2979	Protein of unknown function (DUF533)
C1A23_RS10855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1A23_RS10860	COG1271	oxidase subunit
C1A23_RS10865	COG1294	oxidase, subunit
C1A23_RS10875	COG2814	Major facilitator Superfamily
C1A23_RS10880	COG0656	L-ascorbic acid biosynthetic process
C1A23_RS10910	COG4584	PFAM Integrase catalytic
C1A23_RS10915	COG1484	DNA-dependent DNA replication
C1A23_RS10925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1A23_RS10930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1A23_RS10935	COG2271	Major facilitator Superfamily
C1A23_RS10940	COG1349	DNA-binding transcription factor activity
C1A23_RS10955	COG0584	glycerophosphoryl diester phosphodiesterase
C1A23_RS10960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1A23_RS10965	COG0287	Prephenate dehydrogenase
C1A23_RS10965	COG1605	Chorismate mutase
C1A23_RS10970	COG0583	DNA-binding transcription factor activity
C1A23_RS10975	COG3085	chromosome segregation
C1A23_RS10980	COG4574	serine-type endopeptidase inhibitor activity
C1A23_RS11000	COG1770	oligopeptidase
C1A23_RS11005	COG4771	TonB-dependent receptor
C1A23_RS11010	COG3083	sulfuric ester hydrolase activity
C1A23_RS11015	COG3082	Protein of unknown function (DUF1414)
C1A23_RS11020	COG3081	Nucleoid-associated protein
C1A23_RS11030	COG1175	transmembrane transport
C1A23_RS11035	COG3833	ABC-type maltose transport systems, permease component
C1A23_RS11040	COG3842	ATPase activity
C1A23_RS11060	COG0425	Belongs to the sulfur carrier protein TusA family
C1A23_RS11065	COG4783	chaperone-mediated protein folding
C1A23_RS11070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1A23_RS11075	COG1393	Belongs to the ArsC family
C1A23_RS11090	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C1A23_RS11095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1A23_RS11100	COG2431	L-lysine efflux transmembrane transporter activity
C1A23_RS11110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A23_RS11130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1A23_RS11140	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1A23_RS11145	COG2373	Large extracellular alpha-helical protein
C1A23_RS11150	COG4953	penicillin-binding protein 1C
C1A23_RS11160	COG0301	tRNA thio-modification
C1A23_RS11160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1A23_RS11215	COG1083	cytidylyl-transferase
C1A23_RS11235	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C1A23_RS11240	COG2089	acid synthase
C1A23_RS11250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C1A23_RS11260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1A23_RS11270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1A23_RS11295	COG0483	inositol monophosphate 1-phosphatase activity
C1A23_RS11305	COG0625	glutathione transferase activity
C1A23_RS11310	COG2814	Major facilitator Superfamily
C1A23_RS11330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1A23_RS11335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1A23_RS11340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1A23_RS11345	COG0509	glycine decarboxylation via glycine cleavage system
C1A23_RS11350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1A23_RS11350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1A23_RS11365	COG0640	Transcriptional regulator
C1A23_RS11370	COG0798	PFAM Bile acid sodium symporter
C1A23_RS11375	COG1393	Belongs to the ArsC family
C1A23_RS11395	COG3634	alkyl hydroperoxide reductase activity
C1A23_RS11405	COG0517	IMP dehydrogenase activity
C1A23_RS11410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C1A23_RS11415	COG0343	queuine tRNA-ribosyltransferase activity
C1A23_RS11420	COG1862	Preprotein translocase
C1A23_RS11425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1A23_RS11430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1A23_RS11445	COG0826	peptidase U32
C1A23_RS11450	COG0826	peptidase U32
C1A23_RS11465	COG3154	lipid carrier protein
C1A23_RS11485	COG1104	cysteine desulfurase activity
C1A23_RS11490	COG0822	iron-sulfur transferase activity
C1A23_RS11500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1A23_RS11505	COG0443	Heat shock 70 kDa protein
C1A23_RS11510	COG0633	Ferredoxin
C1A23_RS11520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1A23_RS11525	COG0105	UTP biosynthetic process
C1A23_RS11530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1A23_RS11540	COG1426	Protein conserved in bacteria
C1A23_RS11545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1A23_RS11550	COG0124	histidyl-tRNA synthetase
C1A23_RS11555	COG2976	Protein conserved in bacteria
C1A23_RS11560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1A23_RS11565	COG1160	GTP binding
C1A23_RS11570	COG1645	bacterial-type flagellum-dependent swarming motility
C1A23_RS11580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1A23_RS11585	COG0047	phosphoribosylformylglycinamidine synthase activity
C1A23_RS11585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1A23_RS11590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1A23_RS11590	COG2199	diguanylate cyclase activity
C1A23_RS11605	COG1007	ATP synthesis coupled electron transport
C1A23_RS11610	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1A23_RS11620	COG0713	ATP synthesis coupled electron transport
C1A23_RS11625	COG0839	Belongs to the complex I subunit 6 family
C1A23_RS11630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1A23_RS11635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C1A23_RS11640	COG1034	ATP synthesis coupled electron transport
C1A23_RS11655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1A23_RS11655	COG0649	NAD binding
C1A23_RS11660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1A23_RS11665	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1A23_RS11670	COG1360	Flagellar Motor Protein
C1A23_RS11675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1A23_RS11690	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C1A23_RS11710	COG0724	RNA recognition motif
C1A23_RS11715	COG4989	oxidoreductase activity
C1A23_RS11740	COG3437	response regulator, receiver
C1A23_RS11745	COG0583	DNA-binding transcription factor activity
C1A23_RS11755	COG5001	Diguanylate cyclase
C1A23_RS11755	COG3300	MHYT domain
C1A23_RS11780	COG0583	DNA-binding transcription factor activity
C1A23_RS11790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1A23_RS11795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1A23_RS11800	COG0539	negative regulation of cytoplasmic translation
C1A23_RS11805	COG0776	regulation of translation
C1A23_RS11815	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C1A23_RS11820	COG0284	orotidine-5'-phosphate decarboxylase activity
C1A23_RS11835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C1A23_RS11840	COG0602	queuosine metabolic process
C1A23_RS11845	COG3530	Putative quorum-sensing-regulated virulence factor
C1A23_RS11850	COG2096	Adenosyltransferase
C1A23_RS11855	COG2916	Histone family protein nucleoid-structuring protein H-NS
C1A23_RS11860	COG1757	Na H antiporter
C1A23_RS11865	COG1435	thymidine kinase activity
C1A23_RS11895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1A23_RS11900	COG0840	transmembrane signaling receptor activity
C1A23_RS11910	COG2201	protein-glutamate methylesterase activity
C1A23_RS11920	COG0835	chemotaxis
C1A23_RS11925	COG0840	transmembrane signaling receptor activity
C1A23_RS11930	COG0643	Histidine kinase
C1A23_RS11930	COG2198	Histidine kinase
C1A23_RS11940	COG0745	RESPONSE REGULATOR receiver
C1A23_RS11945	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C1A23_RS11950	COG0437	4 iron, 4 sulfur cluster binding
C1A23_RS11955	COG5557	Pfam Polysulphide reductase, NrfD
C1A23_RS11960	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C1A23_RS11965	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C1A23_RS11980	COG0601	transmembrane transport
C1A23_RS11985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1A23_RS11995	COG3842	ATPase activity
C1A23_RS12000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1A23_RS12005	COG0375	protein maturation
C1A23_RS12010	COG0309	Hydrogenase expression formation protein (HypE)
C1A23_RS12020	COG0298	carbon dioxide binding
C1A23_RS12025	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C1A23_RS12035	COG1921	L-seryl-tRNASec selenium transferase activity
C1A23_RS12045	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C1A23_RS12055	COG3260	NADH ubiquinone oxidoreductase 20
C1A23_RS12060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1A23_RS12065	COG3261	NADH dehydrogenase
C1A23_RS12065	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C1A23_RS12070	COG0650	Formate hydrogenlyase subunit 4
C1A23_RS12075	COG0651	ATP synthesis coupled electron transport
C1A23_RS12080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1A23_RS12085	COG3158	transport of potassium into the cell
C1A23_RS12100	COG3039	Transposase
C1A23_RS12105	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1A23_RS12135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1A23_RS12145	COG0326	Molecular chaperone. Has ATPase activity
C1A23_RS12155	COG0563	adenylate kinase activity
C1A23_RS12160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1A23_RS12170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1A23_RS12185	COG3300	MHYT domain
C1A23_RS12185	COG5001	Diguanylate cyclase
C1A23_RS12190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1A23_RS12210	COG1021	2,3-dihydroxybenzoate-AMP ligase
C1A23_RS12215	COG1535	isochorismatase
C1A23_RS12215	COG3433	isochorismatase activity
C1A23_RS12220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1A23_RS12225	COG1028	Short-chain dehydrogenase reductase Sdr
C1A23_RS12235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1A23_RS12240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C1A23_RS12250	COG1120	ATPase activity
C1A23_RS12255	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1A23_RS12260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1A23_RS12265	COG4771	TonB-dependent receptor
C1A23_RS12290	COG0644	oxidoreductase
C1A23_RS12290	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C1A23_RS12315	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1A23_RS12320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1A23_RS12325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1A23_RS12340	COG1570	exodeoxyribonuclease VII activity
C1A23_RS12345	COG0697	spore germination
C1A23_RS12365	COG3158	transport of potassium into the cell
C1A23_RS12375	COG0516	GMP reductase activity
C1A23_RS12375	COG0517	IMP dehydrogenase activity
C1A23_RS12380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1A23_RS12380	COG0519	Catalyzes the synthesis of GMP from XMP
C1A23_RS12395	COG4584	PFAM Integrase catalytic
C1A23_RS12400	COG1484	DNA-dependent DNA replication
C1A23_RS12445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1A23_RS12500	COG2062	phosphohistidine phosphatase, SixA
C1A23_RS12510	COG0697	spore germination
C1A23_RS12515	COG4166	transmembrane transport
C1A23_RS12520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C1A23_RS12525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1A23_RS12535	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1A23_RS12540	COG1136	(ABC) transporter
C1A23_RS12545	COG4591	ABC-type transport system involved in lipoprotein release permease component
C1A23_RS12550	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1A23_RS12565	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1A23_RS12570	COG0740	serine-type endopeptidase activity
C1A23_RS12575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1A23_RS12580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C1A23_RS12585	COG0776	regulation of translation
C1A23_RS12590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1A23_RS12595	COG0488	(ABC) transporter
C1A23_RS12600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1A23_RS12605	COG3162	membrane
C1A23_RS12620	COG1024	Enoyl-CoA hydratase
C1A23_RS12620	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1A23_RS12625	COG1115	amino acid carrier protein
C1A23_RS12640	COG1584	GPR1 FUN34 yaaH family protein
C1A23_RS12675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1A23_RS12680	COG1960	acyl-CoA dehydrogenase activity
C1A23_RS12690	COG1960	acyl-CoA dehydrogenase activity
C1A23_RS12695	COG1024	Enoyl-CoA hydratase
C1A23_RS12700	COG1024	Enoyl-CoA hydratase
C1A23_RS12710	COG1028	Short-chain dehydrogenase reductase Sdr
C1A23_RS12720	COG0730	response to heat
C1A23_RS12740	COG5001	Diguanylate cyclase
C1A23_RS12740	COG3300	MHYT domain
C1A23_RS12745	COG0583	DNA-binding transcription factor activity
C1A23_RS12750	COG2723	6-phospho-beta-galactosidase activity
C1A23_RS12755	COG3300	MHYT domain
C1A23_RS12755	COG5001	Diguanylate cyclase
C1A23_RS12765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1A23_RS12775	COG0583	DNA-binding transcription factor activity
C1A23_RS12790	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1A23_RS12795	COG0673	inositol 2-dehydrogenase activity
C1A23_RS12800	COG0583	DNA-binding transcription factor activity
C1A23_RS12810	COG1560	Kdo2-lipid A biosynthetic process
C1A23_RS12815	COG1560	Kdo2-lipid A biosynthetic process
C1A23_RS12840	COG0417	DNA replication proofreading
C1A23_RS12870	COG0534	Mate efflux family protein
C1A23_RS12880	COG0307	riboflavin synthase, alpha
C1A23_RS12890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1A23_RS12895	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C1A23_RS12900	COG0697	spore germination
C1A23_RS12905	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1A23_RS12945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1A23_RS12950	COG3099	Belongs to the UPF0263 family
C1A23_RS12955	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C1A23_RS12960	COG2894	cell division
C1A23_RS12965	COG0850	regulation of cytokinetic process
C1A23_RS12970	COG3100	YcgL domain-containing protein
C1A23_RS12975	COG2951	lytic endotransglycosylase activity
C1A23_RS12980	COG1760	l-serine dehydratase
C1A23_RS12990	COG1760	l-serine dehydratase
C1A23_RS12995	COG3123	guanosine phosphorylase activity
C1A23_RS13015	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C1A23_RS13020	COG2067	long-chain fatty acid transport protein
C1A23_RS13035	COG1595	DNA-templated transcription, initiation
C1A23_RS13065	COG0714	Associated with various cellular activities
C1A23_RS13070	COG0183	Belongs to the thiolase family
C1A23_RS13075	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1A23_RS13075	COG1024	Enoyl-CoA hydratase
C1A23_RS13095	COG3829	transcription factor binding
C1A23_RS13100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1A23_RS13105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1A23_RS13110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1A23_RS13120	COG0549	Belongs to the carbamate kinase family
C1A23_RS13125	COG0697	spore germination
C1A23_RS13130	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C1A23_RS13130	COG3608	succinylglutamate desuccinylase aspartoacylase
C1A23_RS13135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1A23_RS13140	COG2068	MobA-Related Protein
C1A23_RS13150	COG0493	'glutamate synthase
C1A23_RS13150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C1A23_RS13155	COG0402	S-adenosylhomocysteine deaminase activity
C1A23_RS13160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C1A23_RS13165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1A23_RS13165	COG2080	2 iron, 2 sulfur cluster binding
C1A23_RS13170	COG2233	PERMEase
C1A23_RS13175	COG0402	S-adenosylhomocysteine deaminase activity
C1A23_RS13180	COG2252	PERMEase
C1A23_RS13185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1A23_RS13190	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C1A23_RS13195	COG2080	2 iron, 2 sulfur cluster binding
C1A23_RS13205	COG3134	Outer membrane lipoprotein
C1A23_RS13215	COG1288	antiporter activity
C1A23_RS13220	COG0318	PFAM AMP-dependent synthetase and ligase
C1A23_RS13230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1A23_RS13230	COG0140	phosphoribosyl-ATP diphosphatase activity
C1A23_RS13235	COG0107	imidazoleglycerol-phosphate synthase activity
C1A23_RS13240	COG0784	Response regulator, receiver
C1A23_RS13240	COG2198	Histidine kinase
C1A23_RS13240	COG2205	protein histidine kinase activity
C1A23_RS13245	COG2199	diguanylate cyclase activity
C1A23_RS13250	COG3437	response regulator, receiver
C1A23_RS13255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1A23_RS13260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1A23_RS13265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1A23_RS13265	COG0131	Imidazoleglycerol-phosphate dehydratase
C1A23_RS13270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1A23_RS13275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1A23_RS13280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1A23_RS13290	COG1199	ATP-dependent helicase activity
C1A23_RS13300	COG1214	PFAM Peptidase M22, glycoprotease
C1A23_RS13310	COG2226	methyltransferase
C1A23_RS13310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1A23_RS13310	COG0596	Alpha beta hydrolase
C1A23_RS13315	COG0318	PFAM AMP-dependent synthetase and ligase
C1A23_RS13320	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1A23_RS13335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1A23_RS13340	COG2832	Protein of unknown function (DUF454)
C1A23_RS13345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1A23_RS13355	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C1A23_RS13380	COG0617	tRNA 3'-terminal CCA addition
C1A23_RS13380	COG0517	IMP dehydrogenase activity
C1A23_RS13380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1A23_RS13385	COG1643	Atp-dependent helicase
C1A23_RS13395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1A23_RS13405	COG3437	response regulator, receiver
C1A23_RS13410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1A23_RS13415	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C1A23_RS13420	COG0709	Synthesizes selenophosphate from selenide and ATP
C1A23_RS13435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1A23_RS13445	COG1254	Belongs to the acylphosphatase family
C1A23_RS13450	COG0625	glutathione transferase activity
C1A23_RS13455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1A23_RS13455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1A23_RS13460	COG0489	protein tyrosine kinase activity
C1A23_RS13465	COG0572	uridine kinase
C1A23_RS13470	COG0717	Belongs to the dCTP deaminase family
C1A23_RS13480	COG0306	phosphate transporter
C1A23_RS13520	COG5001	Diguanylate cyclase
C1A23_RS13520	COG3300	MHYT domain
C1A23_RS13550	COG1484	DNA-dependent DNA replication
C1A23_RS13555	COG4584	PFAM Integrase catalytic
C1A23_RS13590	COG0110	maltose O-acetyltransferase activity
C1A23_RS13680	COG0697	spore germination
C1A23_RS13695	COG1530	ribonuclease E activity
C1A23_RS13700	COG0564	pseudouridine synthase activity
C1A23_RS13705	COG0546	phosphoglycolate phosphatase activity
C1A23_RS13710	COG0424	maF-like protein
C1A23_RS13715	COG2814	Major facilitator Superfamily
C1A23_RS13730	COG1399	metal-binding, possibly nucleic acid-binding protein
C1A23_RS13735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1A23_RS13740	COG0416	fatty acid biosynthetic process
C1A23_RS13745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1A23_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
C1A23_RS13760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1A23_RS13770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1A23_RS13775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1A23_RS13780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1A23_RS13785	COG0470	DNA polymerase III
C1A23_RS13790	COG0084	hydrolase, TatD family'
C1A23_RS13805	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C1A23_RS13805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1A23_RS13810	COG3008	intermembrane lipid transfer
C1A23_RS13815	COG2995	paraquat-inducible protein a
C1A23_RS13825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1A23_RS13830	COG0372	Belongs to the citrate synthase family
C1A23_RS13880	COG4221	oxidoreductase activity
C1A23_RS13890	COG3141	response to X-ray
C1A23_RS13940	COG1484	DNA-dependent DNA replication
C1A23_RS13945	COG4584	PFAM Integrase catalytic
C1A23_RS13995	COG1067	ATP-dependent peptidase activity
C1A23_RS14000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C1A23_RS14015	COG0488	(ABC) transporter
C1A23_RS14025	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1A23_RS14025	COG0116	Belongs to the methyltransferase superfamily
C1A23_RS14035	COG0167	dihydroorotate dehydrogenase activity
C1A23_RS14040	COG2902	Dehydrogenase
C1A23_RS14050	COG0308	aminopeptidase N
C1A23_RS14060	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C1A23_RS14065	COG1956	GAF domain-containing protein
C1A23_RS14075	COG3278	Belongs to the heme-copper respiratory oxidase family
C1A23_RS14090	COG2010	Cytochrome c
C1A23_RS14115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1A23_RS14120	COG0589	response to stress
C1A23_RS14125	COG0037	tRNA processing
C1A23_RS14145	COG1869	D-ribose catabolic process
C1A23_RS14150	COG1129	ABC transporter
C1A23_RS14155	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1A23_RS14160	COG1879	ABC-type sugar transport system periplasmic component
C1A23_RS14165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1A23_RS14170	COG1609	Transcriptional regulator
C1A23_RS14175	COG5001	Diguanylate cyclase
C1A23_RS14175	COG3300	MHYT domain
C1A23_RS14205	COG0776	regulation of translation
C1A23_RS14210	COG0072	phenylalanine-tRNA ligase activity
C1A23_RS14210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1A23_RS14215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1A23_RS14220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1A23_RS14225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1A23_RS14230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1A23_RS14235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1A23_RS14255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1A23_RS14265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1A23_RS14270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1A23_RS14275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1A23_RS14280	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C1A23_RS14285	COG3313	Fe-S protein
C1A23_RS14290	COG2942	2-epimerase
C1A23_RS14295	COG3716	PTS system mannose fructose sorbose family IID component
C1A23_RS14300	COG3715	PTS system
C1A23_RS14305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1A23_RS14305	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A23_RS14320	COG1609	Transcriptional regulator
C1A23_RS14325	COG2140	Oxalate decarboxylase
C1A23_RS14335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1A23_RS14335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1A23_RS14335	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C1A23_RS14340	COG1105	Belongs to the carbohydrate kinase PfkB family
C1A23_RS14345	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A23_RS14345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A23_RS14350	COG1609	Transcriptional regulator
C1A23_RS14355	COG0814	amino acid
C1A23_RS14365	COG5654	RES domain protein
C1A23_RS14370	COG0513	Belongs to the DEAD box helicase family
C1A23_RS14380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1A23_RS14385	COG2890	protein-(glutamine-N5) methyltransferase activity
C1A23_RS14390	COG2840	Smr protein MutS2
C1A23_RS14400	COG3706	GGDEF domain
C1A23_RS14430	COG2824	Alkylphosphonate utilization operon protein PhnA
C1A23_RS14445	COG0384	phenazine biosynthesis protein PhzF
C1A23_RS14475	COG0242	peptide deformylase activity
C1A23_RS14490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1A23_RS14495	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1A23_RS14500	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C1A23_RS14510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1A23_RS14515	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1A23_RS14525	COG0205	6-phosphofructokinase activity
C1A23_RS14530	COG1473	amidohydrolase
C1A23_RS14535	COG1011	Hydrolase
C1A23_RS14540	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1A23_RS14595	COG3593	DNA synthesis involved in DNA repair
C1A23_RS14610	COG0583	DNA-binding transcription factor activity
C1A23_RS14615	COG0730	response to heat
C1A23_RS14620	COG3148	PFAM DTW domain containing protein
C1A23_RS14630	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1A23_RS14645	COG0386	Belongs to the glutathione peroxidase family
C1A23_RS14650	COG0513	Belongs to the DEAD box helicase family
C1A23_RS14665	COG1742	UPF0060 membrane protein
C1A23_RS14695	COG2329	Antibiotic biosynthesis monooxygenase
C1A23_RS14700	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C1A23_RS14720	COG3243	poly(R)-hydroxyalkanoic acid synthase
C1A23_RS14730	COG2501	S4 domain
C1A23_RS14745	COG1132	(ABC) transporter
C1A23_RS14755	COG1132	(ABC) transporter
C1A23_RS14765	COG3118	belongs to the thioredoxin family
C1A23_RS14770	COG0471	metal ion transport
C1A23_RS14775	COG0058	SHG alpha-glucan phosphorylase activity
C1A23_RS14810	COG0814	amino acid
C1A23_RS14815	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C1A23_RS14820	COG0514	ATP-dependent DNA helicase (RecQ)
C1A23_RS14825	COG2766	serine protein kinase
C1A23_RS14835	COG2719	SpoVR family
C1A23_RS14840	COG2186	Transcriptional regulator
C1A23_RS14845	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1A23_RS14850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C1A23_RS14855	COG0586	Pfam SNARE associated Golgi protein
C1A23_RS14865	COG0556	nucleotide-excision repair
C1A23_RS14880	COG0569	domain protein
C1A23_RS14880	COG2985	domain, Protein
C1A23_RS14890	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C1A23_RS14910	COG4565	transcriptional regulatory protein
C1A23_RS14915	COG3290	protein histidine kinase activity
C1A23_RS14920	COG1846	Transcriptional regulator
C1A23_RS14920	COG1940	carbohydrate kinase activity
C1A23_RS14925	COG0840	transmembrane signaling receptor activity
C1A23_RS14930	COG3012	SEC-C Motif Domain Protein
C1A23_RS14935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1A23_RS14940	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C1A23_RS14945	COG0247	lactate metabolic process
C1A23_RS14960	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C1A23_RS14965	COG0437	4 iron, 4 sulfur cluster binding
C1A23_RS14970	COG3301	Polysulphide reductase, NrfD
C1A23_RS14980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1A23_RS14985	COG4235	cytochrome complex assembly
C1A23_RS14985	COG3088	subunit of a heme lyase
C1A23_RS14990	COG1051	belongs to the nudix hydrolase family
C1A23_RS15000	COG3033	Beta-eliminating lyase
C1A23_RS15010	COG3046	protein related to deoxyribodipyrimidine photolyase
C1A23_RS15015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1A23_RS15040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C1A23_RS15045	COG0583	DNA-binding transcription factor activity
C1A23_RS15055	COG4774	siderophore transport
C1A23_RS15070	COG0583	DNA-binding transcription factor activity
C1A23_RS15075	COG2910	NAD(P)H-binding
C1A23_RS15090	COG0612	Peptidase, M16
C1A23_RS15095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1A23_RS15105	COG1944	ATP diphosphatase activity
C1A23_RS15110	COG2116	formate transmembrane transporter activity
C1A23_RS15115	COG1882	Formate acetyltransferase
C1A23_RS15120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1A23_RS15125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1A23_RS15130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1A23_RS15140	COG1840	ABC-type Fe3 transport system, periplasmic component
C1A23_RS15145	COG3842	ATPase activity
C1A23_RS15155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1A23_RS15160	COG2983	Belongs to the UPF0260 family
C1A23_RS15175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1A23_RS15180	COG0045	succinate-CoA ligase (ADP-forming) activity
C1A23_RS15185	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1A23_RS15190	COG0567	Dehydrogenase, E1 component
C1A23_RS15200	COG1053	succinate dehydrogenase
C1A23_RS15205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C1A23_RS15230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1A23_RS15235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1A23_RS15235	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C1A23_RS15245	COG3069	C4-dicarboxylate transmembrane transporter activity
C1A23_RS15260	COG1451	nucleotide metabolic process
C1A23_RS15275	COG0254	rRNA binding
C1A23_RS15280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1A23_RS15290	COG0583	DNA-binding transcription factor activity
C1A23_RS15300	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1A23_RS15310	COG1879	ABC-type sugar transport system periplasmic component
C1A23_RS15315	COG1069	ribulokinase activity
C1A23_RS15325	COG2160	L-arabinose isomerase activity
C1A23_RS15330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C1A23_RS15340	COG2925	Exonuclease
C1A23_RS15350	COG3345	alpha-galactosidase
C1A23_RS15355	COG1380	Effector of murein hydrolase LrgA
C1A23_RS15360	COG1346	cytolysis
C1A23_RS15365	COG0295	cytidine deaminase activity
C1A23_RS15370	COG1022	Amp-dependent synthetase and ligase
C1A23_RS15385	COG0861	Integral membrane protein TerC family
C1A23_RS15390	COG2885	chlorophyll binding
C1A23_RS15395	COG2199	diguanylate cyclase activity
C1A23_RS15415	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1A23_RS15425	COG3768	UPF0283 membrane protein
C1A23_RS15430	COG3106	COG3106 Predicted ATPase
C1A23_RS15445	COG1842	Phage shock protein A
C1A23_RS15450	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C1A23_RS15460	COG4168	peptide transport system, permease
C1A23_RS15465	COG4171	peptide transport system, permease
C1A23_RS15475	COG4172	Belongs to the ABC transporter superfamily
C1A23_RS15485	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1A23_RS15490	COG1286	toxin biosynthetic process
C1A23_RS15495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1A23_RS15500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1A23_RS15505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C1A23_RS15510	COG1674	ftsk spoiiie
C1A23_RS15510	COG0531	amino acid
C1A23_RS15520	COG0686	Belongs to the AlaDH PNT family
C1A23_RS15525	COG0492	ferredoxin-NADP+ reductase activity
C1A23_RS15530	COG3706	GGDEF domain
C1A23_RS15535	COG3134	Outer membrane lipoprotein
C1A23_RS15540	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C1A23_RS15545	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C1A23_RS15550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1A23_RS15555	COG0542	response to heat
C1A23_RS15560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1A23_RS15565	COG1278	Cold shock
C1A23_RS15570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1A23_RS15590	COG4584	PFAM Integrase catalytic
C1A23_RS15595	COG1484	DNA-dependent DNA replication
C1A23_RS15640	COG3829	transcription factor binding
C1A23_RS15695	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C1A23_RS15715	COG3501	Rhs element vgr protein
C1A23_RS15730	COG0659	secondary active sulfate transmembrane transporter activity
C1A23_RS15760	COG0672	)-iron permease
C1A23_RS15780	COG2814	Major facilitator Superfamily
C1A23_RS15790	COG1136	(ABC) transporter
C1A23_RS15795	COG0577	efflux transmembrane transporter activity
C1A23_RS15840	COG1139	Iron-sulfur cluster binding protein
C1A23_RS15845	COG0247	lactate metabolic process
C1A23_RS15850	COG1620	l-lactate permease
C1A23_RS15855	COG0583	DNA-binding transcription factor activity
C1A23_RS15865	COG0346	lactoylglutathione lyase activity
C1A23_RS15870	COG0596	Alpha beta hydrolase
C1A23_RS15895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1A23_RS15900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1A23_RS15900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1A23_RS15905	COG0527	aspartate kinase activity
C1A23_RS15915	COG1368	sulfuric ester hydrolase activity
C1A23_RS15920	COG1619	proteins homologs of microcin C7 resistance protein MccF
C1A23_RS15925	COG4667	esterase of the alpha-beta hydrolase superfamily
C1A23_RS15945	COG1648	precorrin-2 dehydrogenase activity
C1A23_RS15945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1A23_RS15955	COG0393	Putative heavy-metal-binding
C1A23_RS15975	COG1252	NADH dehydrogenase
C1A23_RS15980	COG3150	esterase
C1A23_RS15985	COG2233	PERMEase
C1A23_RS16005	COG2354	Protein conserved in bacteria
C1A23_RS16015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1A23_RS16020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1A23_RS16055	COG0537	adenosine 5'-monophosphoramidase activity
C1A23_RS16070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1A23_RS16085	COG1301	dicarboxylic acid transport
C1A23_RS16095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1A23_RS16100	COG0861	Integral membrane protein TerC family
C1A23_RS16115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1A23_RS16120	COG0601	transmembrane transport
C1A23_RS16130	COG2095	MarC family integral membrane protein
C1A23_RS16140	COG1012	belongs to the aldehyde dehydrogenase family
C1A23_RS16140	COG1454	alcohol dehydrogenase
C1A23_RS16145	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1A23_RS16145	COG2199	diguanylate cyclase activity
C1A23_RS16150	COG3275	phosphorelay sensor kinase activity
C1A23_RS16155	COG3279	Response regulator of the LytR AlgR family
C1A23_RS16160	COG1966	Carbon starvation protein
C1A23_RS16170	COG1566	PFAM secretion protein HlyD family protein
C1A23_RS16175	COG1061	Type III restriction enzyme res subunit
C1A23_RS16180	COG2027	D-alanyl-D-alanine carboxypeptidase
C1A23_RS16185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1A23_RS16195	COG0436	Aminotransferase
C1A23_RS16200	COG1288	antiporter activity
C1A23_RS16205	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1A23_RS16225	COG0697	spore germination
C1A23_RS16230	COG4657	Part of a membrane complex involved in electron transport
C1A23_RS16235	COG2878	Part of a membrane complex involved in electron transport
C1A23_RS16245	COG4658	electron transport chain
C1A23_RS16250	COG4659	FMN binding
C1A23_RS16255	COG4660	Part of a membrane complex involved in electron transport
C1A23_RS16260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C1A23_RS16265	COG0346	lactoylglutathione lyase activity
C1A23_RS16280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C1A23_RS16285	COG2056	Na+-H+ antiporter family
C1A23_RS16295	COG2050	protein possibly involved in aromatic compounds catabolism
C1A23_RS16305	COG0247	lactate metabolic process
C1A23_RS16305	COG0277	FAD linked oxidase domain protein
C1A23_RS16315	COG1253	flavin adenine dinucleotide binding
C1A23_RS16320	COG1902	pentaerythritol trinitrate reductase activity
C1A23_RS16330	COG0647	UMP catabolic process
C1A23_RS16335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1A23_RS16335	COG4651	solute:proton antiporter activity
C1A23_RS16345	COG0367	asparagine synthase
C1A23_RS16355	COG0625	glutathione transferase activity
C1A23_RS16360	COG0625	glutathione transferase activity
C1A23_RS16370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1A23_RS16385	COG0564	pseudouridine synthase activity
C1A23_RS16390	COG5001	Diguanylate cyclase
C1A23_RS16395	COG0840	transmembrane signaling receptor activity
C1A23_RS16405	COG0392	lysyltransferase activity
C1A23_RS16405	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C1A23_RS16415	COG2194	sulfuric ester hydrolase activity
C1A23_RS16435	COG0670	Belongs to the BI1 family
C1A23_RS16440	COG1289	transmembrane transporter activity
C1A23_RS16445	COG2920	part of a sulfur-relay system
C1A23_RS16450	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C1A23_RS16455	COG0285	dihydrofolate synthase activity
C1A23_RS16460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C1A23_RS16465	COG0101	tRNA pseudouridine synthase activity
C1A23_RS16475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1A23_RS16480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1A23_RS16485	COG0671	phosphoesterase, PA-phosphatase related
C1A23_RS16490	COG1464	Belongs to the NlpA lipoprotein family
C1A23_RS16530	COG0574	Belongs to the PEP-utilizing enzyme family
C1A23_RS16530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1A23_RS16535	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C1A23_RS16605	COG1242	4 iron, 4 sulfur cluster binding
C1A23_RS16610	COG0069	glutamate synthase activity
C1A23_RS16610	COG0070	glutamate synthase
C1A23_RS16610	COG0067	glutamate synthase
C1A23_RS16615	COG0493	'glutamate synthase
C1A23_RS16620	COG1126	abc transporter atp-binding protein
C1A23_RS16625	COG0765	amino acid transport
C1A23_RS16660	COG0789	Transcriptional regulator
C1A23_RS16675	COG4104	PAAR repeat-containing protein
C1A23_RS16685	COG0513	Belongs to the DEAD box helicase family
C1A23_RS16690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1A23_RS16720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1A23_RS16725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1A23_RS16730	COG0505	Belongs to the CarA family
C1A23_RS16735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1A23_RS16745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1A23_RS16750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C1A23_RS16755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1A23_RS16760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1A23_RS16765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1A23_RS16775	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C1A23_RS16785	COG2205	protein histidine kinase activity
C1A23_RS16785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A23_RS16800	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1A23_RS16825	COG0023	Translation Initiation Factor
C1A23_RS16830	COG2119	membrane
C1A23_RS16860	COG2203	Gaf domain
C1A23_RS16860	COG2199	diguanylate cyclase activity
C1A23_RS16875	COG1204	response to ionizing radiation
C1A23_RS16880	COG5433	transposase activity
C1A23_RS16890	COG0215	cysteine-tRNA ligase activity
C1A23_RS16895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1A23_RS16905	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1A23_RS16910	COG3301	Polysulphide reductase, NrfD
C1A23_RS16915	COG0437	4 iron, 4 sulfur cluster binding
C1A23_RS16920	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C1A23_RS16995	COG2314	TM2 domain
C1A23_RS17015	COG0582	viral genome integration into host DNA
C1A23_RS17035	COG4584	PFAM Integrase catalytic
C1A23_RS17040	COG1484	DNA-dependent DNA replication
C1A23_RS17120	COG0322	excinuclease ABC activity
C1A23_RS17125	COG2197	response regulator
C1A23_RS17130	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C1A23_RS17135	COG2835	tetraacyldisaccharide 4'-kinase activity
C1A23_RS17140	COG1663	tetraacyldisaccharide 4'-kinase activity
C1A23_RS17150	COG2333	competence protein COMEC
C1A23_RS17150	COG0658	competence protein
C1A23_RS17165	COG0433	COG0433 Predicted ATPase
C1A23_RS17170	COG1448	Aminotransferase
C1A23_RS17185	COG3385	transposase activity
C1A23_RS17195	COG1199	ATP-dependent helicase activity
C1A23_RS17205	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1A23_RS17210	COG0477	Major facilitator Superfamily
C1A23_RS17220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C1A23_RS17245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1A23_RS17260	COG2271	Major facilitator Superfamily
C1A23_RS17270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A23_RS17275	COG0765	amino acid transport
C1A23_RS17280	COG1126	abc transporter atp-binding protein
C1A23_RS17300	COG0531	amino acid
C1A23_RS17315	COG1253	flavin adenine dinucleotide binding
C1A23_RS17320	COG0704	Plays a role in the regulation of phosphate uptake
C1A23_RS17325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1A23_RS17330	COG0581	inorganic phosphate transmembrane transporter activity
C1A23_RS17335	COG0573	inorganic phosphate transmembrane transporter activity
C1A23_RS17340	COG0590	tRNA wobble adenosine to inosine editing
C1A23_RS17350	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C1A23_RS17370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1A23_RS17375	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1A23_RS17380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1A23_RS17385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1A23_RS17410	COG2716	regulation of RNA biosynthetic process
C1A23_RS17415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1A23_RS17425	COG2239	Acts as a magnesium transporter
C1A23_RS17435	COG1256	bacterial-type flagellum assembly
C1A23_RS17445	COG1706	bacterial-type flagellum-dependent cell motility
C1A23_RS17450	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C1A23_RS17460	COG4787	bacterial-type flagellum-dependent cell motility
C1A23_RS17480	COG1815	bacterial-type flagellum-dependent cell motility
C1A23_RS17485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C1A23_RS17490	COG0835	chemotaxis
C1A23_RS17490	COG0784	Response regulator, receiver
C1A23_RS17495	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C1A23_RS17510	COG0622	Phosphoesterase
C1A23_RS17540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1A23_RS17545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1A23_RS17550	COG1882	Formate acetyltransferase
C1A23_RS17555	COG1349	DNA-binding transcription factor activity
C1A23_RS17590	COG1278	Cold shock
C1A23_RS17610	COG2988	succinylglutamate desuccinylase activity
C1A23_RS17630	COG3132	Protein of unknown function, DUF480
C1A23_RS17640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1A23_RS17665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1A23_RS17720	COG0438	transferase activity, transferring glycosyl groups
C1A23_RS17740	COG1216	Glycosyl transferase, family 2
C1A23_RS17750	COG5039	Polysaccharide pyruvyl transferase
C1A23_RS17775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1A23_RS17795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C1A23_RS17830	COG1091	dTDP-4-dehydrorhamnose reductase activity
C1A23_RS17845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1A23_RS17850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A23_RS17855	COG1309	transcriptional regulator
C1A23_RS17870	COG1946	Acyl-CoA thioesterase
C1A23_RS17880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1A23_RS17890	COG0009	L-threonylcarbamoyladenylate synthase
C1A23_RS17900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1A23_RS17905	COG0512	Glutamine amidotransferase of anthranilate synthase
C1A23_RS17905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1A23_RS17910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1A23_RS17915	COG0134	indole-3-glycerol-phosphate synthase activity
C1A23_RS17915	COG0135	phosphoribosylanthranilate isomerase activity
C1A23_RS17920	COG0133	tryptophan synthase activity
C1A23_RS17925	COG0159	tryptophan synthase activity
C1A23_RS17995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1A23_RS18020	COG3311	Transcriptional regulator
C1A23_RS18035	COG1335	isochorismatase
C1A23_RS18040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1A23_RS18045	COG1304	FMN binding
C1A23_RS18050	COG0549	Belongs to the carbamate kinase family
C1A23_RS18065	COG0583	DNA-binding transcription factor activity
C1A23_RS18105	COG2003	Belongs to the UPF0758 family
C1A23_RS18150	COG3381	protein complex oligomerization
C1A23_RS18160	COG3005	denitrification pathway
C1A23_RS18165	COG0745	RESPONSE REGULATOR receiver
C1A23_RS18175	COG1879	ABC-type sugar transport system periplasmic component
C1A23_RS18180	COG2205	protein histidine kinase activity
C1A23_RS18180	COG0784	Response regulator, receiver
C1A23_RS18180	COG2198	Histidine kinase
C1A23_RS18190	COG2814	Major facilitator Superfamily
C1A23_RS18195	COG0109	protoheme IX farnesyltransferase activity
C1A23_RS18200	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C1A23_RS18205	COG1845	cytochrome c oxidase, subunit III
C1A23_RS18210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1A23_RS18215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1A23_RS18260	COG2211	Major facilitator Superfamily
C1A23_RS18275	COG0708	Exodeoxyribonuclease III
C1A23_RS18295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A23_RS18300	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1A23_RS18320	COG0095	Lipoate-protein ligase
C1A23_RS18340	COG2391	methyltransferase activity
C1A23_RS18350	COG0640	Transcriptional regulator
C1A23_RS18365	COG1285	pathogenesis
C1A23_RS18395	COG0484	heat shock protein binding
C1A23_RS18400	COG0443	Heat shock 70 kDa protein
C1A23_RS18405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1A23_RS18410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1A23_RS18415	COG0497	DNA recombination
C1A23_RS18420	COG1227	inorganic diphosphatase activity
C1A23_RS18430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A23_RS18435	COG1136	(ABC) transporter
C1A23_RS18435	COG0577	efflux transmembrane transporter activity
C1A23_RS18445	COG2375	cellular response to nickel ion
C1A23_RS18450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C1A23_RS18470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1A23_RS18475	COG1396	sequence-specific DNA binding
C1A23_RS18475	COG1917	Cupin 2, conserved barrel domain protein
C1A23_RS18490	COG0531	amino acid
C1A23_RS18495	COG0531	amino acid
C1A23_RS18505	COG1283	sodium-dependent phosphate transmembrane transporter activity
C1A23_RS18515	COG3384	dioxygenase
C1A23_RS18520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A23_RS18520	COG2205	protein histidine kinase activity
C1A23_RS18535	COG0813	purine-nucleoside phosphorylase activity
C1A23_RS18560	COG2801	Transposase and inactivated derivatives
C1A23_RS18570	COG4319	ketosteroid isomerase
C1A23_RS18575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1A23_RS18580	COG0083	homoserine kinase activity
C1A23_RS18595	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1A23_RS18600	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C1A23_RS18615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1A23_RS18625	COG0745	RESPONSE REGULATOR receiver
C1A23_RS18640	COG4988	ABC transporter
C1A23_RS18645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1A23_RS18665	COG1720	tRNA m6t6A37 methyltransferase activity
C1A23_RS18680	COG0542	response to heat
C1A23_RS18685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1A23_RS18690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A23_RS18700	COG2190	(PTS) system
C1A23_RS18715	COG3038	cytochrome b561
C1A23_RS18725	COG0419	ATPase involved in DNA repair
C1A23_RS18730	COG0420	3'-5' exonuclease activity
C1A23_RS18740	COG2974	May be involved in recombination
C1A23_RS18750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1A23_RS18750	COG4651	solute:proton antiporter activity
C1A23_RS18765	COG0469	pyruvate kinase activity
C1A23_RS18770	COG1196	nuclear chromosome segregation
C1A23_RS18770	COG3264	Mechanosensitive ion channel
C1A23_RS18790	COG0281	malic enzyme
C1A23_RS18805	COG0437	4 iron, 4 sulfur cluster binding
C1A23_RS18810	COG3383	formate dehydrogenase (NAD+) activity
C1A23_RS18810	COG3383	formate dehydrogenase (NAD+) activity
C1A23_RS18850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1A23_RS18855	COG1910	domain protein
C1A23_RS18860	COG3852	Histidine kinase
C1A23_RS18865	COG2204	response regulator
C1A23_RS18875	COG4662	Binding-protein-dependent transport system inner membrane component
C1A23_RS18885	COG0746	molybdenum cofactor guanylyltransferase activity
C1A23_RS18890	COG0303	'Molybdopterin
C1A23_RS18895	COG1289	transmembrane transporter activity
C1A23_RS18925	COG3220	belongs to the UPF0276 family
C1A23_RS18955	COG0784	Response regulator, receiver
C1A23_RS18955	COG2205	protein histidine kinase activity
C1A23_RS18960	COG4166	transmembrane transport
C1A23_RS18965	COG0601	transmembrane transport
C1A23_RS18970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1A23_RS18975	COG0444	Belongs to the ABC transporter superfamily
C1A23_RS18980	COG4608	Belongs to the ABC transporter superfamily
C1A23_RS18990	COG2971	BadF BadG BcrA BcrD
C1A23_RS19000	COG0840	transmembrane signaling receptor activity
C1A23_RS19020	COG3724	N-succinylarginine dihydrolase activity
C1A23_RS19025	COG0616	signal peptide processing
C1A23_RS19030	COG1028	Short-chain dehydrogenase reductase Sdr
C1A23_RS19035	COG0583	DNA-binding transcription factor activity
C1A23_RS19045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C1A23_RS19055	COG0583	DNA-binding transcription factor activity
C1A23_RS19060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1A23_RS19065	COG1881	PFAM PEBP family protein
C1A23_RS19075	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C1A23_RS19075	COG3408	Glycogen debranching enzyme
C1A23_RS19080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1A23_RS19085	COG0739	heme binding
C1A23_RS19090	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C1A23_RS19115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C1A23_RS19125	COG3091	SprT-like family
C1A23_RS19135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C1A23_RS19140	COG0189	ligase activity
C1A23_RS19150	COG1678	Uncharacterized ACR, COG1678
C1A23_RS19155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1A23_RS19160	COG3104	oligopeptide transport
C1A23_RS19195	COG0714	Associated with various cellular activities
C1A23_RS19210	COG1115	amino acid carrier protein
C1A23_RS19215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1A23_RS19230	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1A23_RS19240	COG1301	dicarboxylic acid transport
C1A23_RS19245	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C1A23_RS19250	COG2912	Transglutaminase-like superfamily
C1A23_RS19260	COG2890	protein-(glutamine-N5) methyltransferase activity
C1A23_RS19265	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1A23_RS19270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1A23_RS19275	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C1A23_RS19280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1A23_RS19290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1A23_RS19295	COG0737	Belongs to the 5'-nucleotidase family
C1A23_RS19300	COG0193	aminoacyl-tRNA hydrolase activity
C1A23_RS19305	COG0012	GTP binding
C1A23_RS19350	COG0471	metal ion transport
C1A23_RS19350	COG0490	domain, Protein
C1A23_RS19360	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C1A23_RS19380	COG0366	Alpha amylase catalytic
C1A23_RS19390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1A23_RS19390	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1A23_RS19390	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1A23_RS19390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1A23_RS19400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1A23_RS19410	COG1012	belongs to the aldehyde dehydrogenase family
C1A23_RS19420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1A23_RS19435	COG0180	Tryptophanyl-tRNA synthetase
C1A23_RS19445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1A23_RS19455	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C1A23_RS19465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1A23_RS19470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1A23_RS19500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1A23_RS19505	COG0583	DNA-binding transcription factor activity
C1A23_RS19525	COG0583	DNA-binding transcription factor activity
C1A23_RS19540	COG0739	heme binding
C1A23_RS19550	COG1511	domain protein
C1A23_RS19550	COG3264	Mechanosensitive ion channel
C1A23_RS19555	COG0584	glycerophosphoryl diester phosphodiesterase
C1A23_RS19565	COG1053	succinate dehydrogenase
C1A23_RS19570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1A23_RS19575	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C1A23_RS19600	COG3214	Protein conserved in bacteria
C1A23_RS19640	COG0642	Histidine kinase
C1A23_RS19650	COG0516	GMP reductase activity
C1A23_RS19660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1A23_RS19665	COG3647	Membrane
C1A23_RS19675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1A23_RS19685	COG3706	GGDEF domain
C1A23_RS19695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1A23_RS19710	COG3706	GGDEF domain
C1A23_RS19720	COG1335	isochorismatase
C1A23_RS19725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1A23_RS19730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1A23_RS19735	COG1702	phosphate starvation-inducible protein PhoH
C1A23_RS19740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1A23_RS19745	COG4535	Mg2 and Co2 transporter CorC
C1A23_RS19750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1A23_RS19755	COG2888	peptidyl-tyrosine sulfation
C1A23_RS19760	COG0495	leucyl-tRNA aminoacylation
C1A23_RS19780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1A23_RS19785	COG0799	negative regulation of ribosome biogenesis
C1A23_RS19790	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C1A23_RS19795	COG0768	penicillin binding
C1A23_RS19800	COG0772	Belongs to the SEDS family
C1A23_RS19805	COG2951	lytic endotransglycosylase activity
C1A23_RS19810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1A23_RS19815	COG1686	Belongs to the peptidase S11 family
C1A23_RS19820	COG2921	Belongs to the UPF0250 family
C1A23_RS19825	COG0321	lipoyl(octanoyl) transferase activity
C1A23_RS19835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1A23_RS19845	COG3545	Serine hydrolase
C1A23_RS19850	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C1A23_RS19865	COG0789	Transcriptional regulator
C1A23_RS19875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1A23_RS19880	COG1970	mechanosensitive ion channel activity
C1A23_RS19890	COG4974	Belongs to the 'phage' integrase family
C1A23_RS19905	COG0312	modulator of DNA gyrase
C1A23_RS19910	COG0312	modulator of DNA gyrase
C1A23_RS19975	COG3275	phosphorelay sensor kinase activity
C1A23_RS19980	COG3279	Response regulator of the LytR AlgR family
C1A23_RS19985	COG1966	Carbon starvation protein
C1A23_RS19995	COG0114	fumarate hydratase activity
C1A23_RS20005	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C1A23_RS20015	COG2211	Major facilitator Superfamily
C1A23_RS20020	COG1185	polyribonucleotide nucleotidyltransferase activity
C1A23_RS20025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1A23_RS20030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1A23_RS20035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1A23_RS20040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1A23_RS20045	COG0195	Participates in both transcription termination and antitermination
C1A23_RS20050	COG0779	Required for maturation of 30S ribosomal subunits
C1A23_RS20065	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1A23_RS20070	COG0149	triose-phosphate isomerase activity
C1A23_RS20075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1A23_RS20080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1A23_RS20090	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C1A23_RS20095	COG1534	Rna-binding protein
C1A23_RS20110	COG1360	Flagellar Motor Protein
C1A23_RS20115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1A23_RS20120	COG1722	exodeoxyribonuclease VII activity
C1A23_RS20125	COG0142	geranyltranstransferase activity
C1A23_RS20130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1A23_RS20140	COG0601	transmembrane transport
C1A23_RS20150	COG4172	Belongs to the ABC transporter superfamily
C1A23_RS20155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C1A23_RS20160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C1A23_RS20165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1A23_RS20170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1A23_RS20190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1A23_RS20190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1A23_RS20195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1A23_RS20210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1A23_RS20220	COG3381	protein complex oligomerization
C1A23_RS20240	COG3300	MHYT domain
C1A23_RS20240	COG5001	Diguanylate cyclase
C1A23_RS20250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1A23_RS20255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1A23_RS20260	COG0511	ligase activity, forming carbon-carbon bonds
C1A23_RS20265	COG0439	Biotin carboxylase
C1A23_RS20275	COG4145	pantothenate transmembrane transporter activity
C1A23_RS20280	COG1263	PTS System
C1A23_RS20280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1A23_RS20280	COG2190	(PTS) system
C1A23_RS20285	COG0583	DNA-binding transcription factor activity
C1A23_RS20290	COG0604	alcohol dehydrogenase
C1A23_RS20295	COG2264	protein methyltransferase activity
C1A23_RS20310	COG0778	Nitroreductase
C1A23_RS20315	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1A23_RS20315	COG1902	pentaerythritol trinitrate reductase activity
C1A23_RS20320	COG0616	signal peptide processing
C1A23_RS20340	COG3139	Protein of unknown function (DUF1315)
C1A23_RS20345	COG0252	asparaginase activity
C1A23_RS20350	COG0786	glutamate:sodium symporter activity
C1A23_RS20365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1A23_RS20370	COG0384	phenazine biosynthesis protein PhzF
C1A23_RS20375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1A23_RS20380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1A23_RS20385	COG0175	sulfate reduction
C1A23_RS20390	COG2113	Glycine betaine
C1A23_RS20400	COG4175	Glycine betaine
C1A23_RS20410	COG3610	response to peptide
C1A23_RS20415	COG2966	Psort location CytoplasmicMembrane, score
C1A23_RS20435	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1A23_RS20445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1A23_RS20450	COG1028	Short-chain dehydrogenase reductase Sdr
C1A23_RS20460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1A23_RS20485	COG2986	histidine ammonia-lyase
C1A23_RS20510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1A23_RS20550	COG1858	cytochrome C peroxidase
C1A23_RS20565	COG2313	pseudouridylate synthase activity
C1A23_RS20570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1A23_RS20575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1A23_RS20575	COG2146	nitrite reductase [NAD(P)H] activity
C1A23_RS20580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1A23_RS20580	COG2146	nitrite reductase [NAD(P)H] activity
C1A23_RS20585	COG1116	anion transmembrane transporter activity
C1A23_RS20590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1A23_RS20595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1A23_RS20595	COG1116	anion transmembrane transporter activity
C1A23_RS20610	COG0243	molybdopterin cofactor binding
C1A23_RS20645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1A23_RS20660	COG1073	alpha beta
C1A23_RS20665	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C1A23_RS20680	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1A23_RS20690	COG4608	Belongs to the ABC transporter superfamily
C1A23_RS20695	COG0444	Belongs to the ABC transporter superfamily
C1A23_RS20705	COG4239	(ABC) transporter, permease
C1A23_RS20710	COG4174	ABC transporter (Permease)
C1A23_RS20725	COG0811	peptide transport
C1A23_RS20730	COG0811	peptide transport
C1A23_RS20735	COG0848	biopolymer transport protein
C1A23_RS20785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1A23_RS20790	COG0840	transmembrane signaling receptor activity
C1A23_RS20800	COG1278	Cold shock
C1A23_RS20840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1A23_RS20845	COG1162	GTPase activity
C1A23_RS20850	COG0688	phosphatidylethanolamine metabolic process
C1A23_RS20855	COG4628	conserved protein (DUF2132)
C1A23_RS20870	COG3059	membrane
C1A23_RS20875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1A23_RS20880	COG2207	Transcriptional regulator
C1A23_RS20890	COG5001	Diguanylate cyclase
C1A23_RS20890	COG3300	MHYT domain
C1A23_RS20895	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C1A23_RS20915	COG3706	GGDEF domain
C1A23_RS20915	COG4251	negative regulation of phosphorylation
C1A23_RS20915	COG2203	Gaf domain
C1A23_RS20915	COG5001	Diguanylate cyclase
C1A23_RS20925	COG3039	Transposase
C1A23_RS20970	COG4974	Belongs to the 'phage' integrase family
C1A23_RS20980	COG4735	regulation of single-species biofilm formation
C1A23_RS20990	COG1484	DNA-dependent DNA replication
C1A23_RS20995	COG4584	PFAM Integrase catalytic
C1A23_RS21000	COG2314	TM2 domain
C1A23_RS21030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1A23_RS21040	COG3621	Patatin-like phospholipase
C1A23_RS21050	COG0582	viral genome integration into host DNA
C1A23_RS21075	COG1132	(ABC) transporter
C1A23_RS21085	COG1404	Belongs to the peptidase S8 family
C1A23_RS21090	COG2897	thiosulfate sulfurtransferase activity
C1A23_RS21095	COG2066	Belongs to the glutaminase family
C1A23_RS21100	COG3171	Protein conserved in bacteria
C1A23_RS21105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1A23_RS21110	COG4935	Belongs to the peptidase S8 family
C1A23_RS21110	COG2234	aminopeptidase activity
C1A23_RS21115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1A23_RS21120	COG2200	EAL domain
C1A23_RS21125	COG1090	epimerase
C1A23_RS21130	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C1A23_RS21135	COG4181	ATPase activity
C1A23_RS21140	COG2755	lipolytic protein G-D-S-L family
C1A23_RS21145	COG0835	chemotaxis
C1A23_RS21145	COG0784	Response regulator, receiver
C1A23_RS21155	COG0569	domain protein
C1A23_RS21155	COG2985	domain, Protein
C1A23_RS21160	COG1272	protein, Hemolysin III
C1A23_RS21165	COG0076	glutamate decarboxylase activity
C1A23_RS21170	COG2917	probably involved in intracellular septation
C1A23_RS21175	COG2350	Protein conserved in bacteria
C1A23_RS21185	COG1555	photosystem II stabilization
C1A23_RS21190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1A23_RS21195	COG3104	oligopeptide transport
C1A23_RS21200	COG0745	RESPONSE REGULATOR receiver
C1A23_RS21230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A23_RS21245	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C1A23_RS21270	COG0732	type I restriction modification DNA specificity domain
C1A23_RS21280	COG1484	DNA-dependent DNA replication
C1A23_RS21295	COG0840	transmembrane signaling receptor activity
C1A23_RS21325	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1A23_RS21350	COG0732	type I restriction modification DNA specificity domain
C1A23_RS21355	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C1A23_RS21405	COG2003	Belongs to the UPF0758 family
C1A23_RS21460	COG5377	YqaJ viral recombinase family
C1A23_RS21480	COG4983	Phage plasmid primase, P4 family domain protein
C1A23_RS21500	COG1280	lysine exporter protein (LysE YggA)
C1A23_RS21535	COG2070	2-Nitropropane dioxygenase
C1A23_RS21560	COG1858	cytochrome C peroxidase
C1A23_RS21565	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C1A23_RS21585	COG0513	Belongs to the DEAD box helicase family
C1A23_RS21625	COG2957	Belongs to the agmatine deiminase family
C1A23_RS21640	COG1902	pentaerythritol trinitrate reductase activity
C1A23_RS21680	COG5001	Diguanylate cyclase
C1A23_RS21680	COG3300	MHYT domain
C1A23_RS21690	COG0714	Associated with various cellular activities
C1A23_RS21700	COG0456	acetyltransferase
C1A23_RS21710	COG1022	Amp-dependent synthetase and ligase
C1A23_RS21720	COG2918	glutathione biosynthetic process
C1A23_RS21725	COG0612	Peptidase, M16
C1A23_RS21730	COG1238	metal cluster binding
C1A23_RS21755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1A23_RS21760	COG0359	binds to the 23S rRNA
C1A23_RS21765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1A23_RS21770	COG0360	Binds together with S18 to 16S ribosomal RNA
C1A23_RS21775	COG1914	H( )-stimulated, divalent metal cation uptake system
C1A23_RS21780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1A23_RS21795	COG2153	protein acetylation
C1A23_RS21805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1A23_RS21810	COG0557	exoribonuclease II activity
C1A23_RS21815	COG3706	GGDEF domain
C1A23_RS21820	COG1854	S-ribosylhomocysteine lyase activity
C1A23_RS21835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1A23_RS21835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C1A23_RS21890	COG4970	Tfp pilus assembly protein FimT
C1A23_RS21895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1A23_RS21900	COG1047	Peptidyl-prolyl cis-trans
C1A23_RS21905	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1A23_RS21910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1A23_RS21915	COG0196	riboflavin kinase activity
C1A23_RS21920	COG0728	peptidoglycan biosynthetic process
C1A23_RS21925	COG0268	Binds directly to 16S ribosomal RNA
C1A23_RS21930	COG0640	Transcriptional regulator
C1A23_RS21935	COG0583	DNA-binding transcription factor activity
C1A23_RS21945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1A23_RS21950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C1A23_RS21955	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1A23_RS21965	COG1051	belongs to the nudix hydrolase family
C1A23_RS21970	COG3066	DNA modification
C1A23_RS21980	COG0335	large ribosomal subunit rRNA binding
C1A23_RS21985	COG0336	Belongs to the RNA methyltransferase TrmD family
C1A23_RS21990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1A23_RS21995	COG0228	four-way junction DNA binding
C1A23_RS22000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1A23_RS22005	COG4137	Cytochrome C assembly protein
C1A23_RS22010	COG4536	flavin adenine dinucleotide binding
C1A23_RS22020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1A23_RS22020	COG1017	nitric oxide dioxygenase activity
C1A23_RS22025	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C1A23_RS22030	COG0039	L-malate dehydrogenase activity
C1A23_RS22035	COG4160	amino acid transport
C1A23_RS22040	COG4215	(ABC) transporter
C1A23_RS22045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A23_RS22050	COG1126	abc transporter atp-binding protein
C1A23_RS22055	COG1438	arginine binding
C1A23_RS22060	COG2837	iron assimilation
C1A23_RS22065	COG3842	ATPase activity
C1A23_RS22075	COG1840	ABC-type Fe3 transport system, periplasmic component
C1A23_RS22080	COG0347	Belongs to the P(II) protein family
C1A23_RS22095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1A23_RS22100	COG0583	DNA-binding transcription factor activity
C1A23_RS22115	COG1929	Belongs to the glycerate kinase type-1 family
C1A23_RS22120	COG2610	gluconate transmembrane transporter activity
C1A23_RS22125	COG3835	regulator
C1A23_RS22130	COG3112	Uncharacterised protein family (UPF0231)
C1A23_RS22145	COG0840	transmembrane signaling receptor activity
C1A23_RS22165	COG0513	Belongs to the DEAD box helicase family
C1A23_RS22205	COG1448	Aminotransferase
C1A23_RS22220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C1A23_RS22225	COG1328	CTP reductase activity
C1A23_RS22245	COG4946	Tricorn protease homolog
C1A23_RS22245	COG0793	Belongs to the peptidase S41A family
C1A23_RS22280	COG0840	transmembrane signaling receptor activity
C1A23_RS22285	COG3397	chitin binding
C1A23_RS22290	COG0583	DNA-binding transcription factor activity
C1A23_RS22295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1A23_RS22300	COG4208	sulfate ABC transporter
C1A23_RS22305	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C1A23_RS22315	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C1A23_RS22320	COG3174	membrane
C1A23_RS22325	COG0110	maltose O-acetyltransferase activity
C1A23_RS22345	COG0165	Argininosuccinate lyase
C1A23_RS22350	COG0137	argininosuccinate synthase activity
C1A23_RS22360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1A23_RS22365	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1A23_RS22375	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1A23_RS22390	COG0460	homoserine dehydrogenase
C1A23_RS22390	COG0527	aspartate kinase activity
C1A23_RS22395	COG0626	cystathionine gamma-synthase activity
C1A23_RS22405	COG3708	Transcriptional regulator
C1A23_RS22405	COG2207	Transcriptional regulator
C1A23_RS22410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1A23_RS22415	COG0814	amino acid
C1A23_RS22420	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1A23_RS22425	COG0494	nUDIX hydrolase
C1A23_RS22430	COG1011	Hydrolase
C1A23_RS22435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1A23_RS22450	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C1A23_RS22460	COG3156	type II secretion system protein K
C1A23_RS22475	COG4795	General secretion pathway protein
C1A23_RS22480	COG2165	general secretion pathway protein
C1A23_RS22495	COG2165	general secretion pathway protein
C1A23_RS22500	COG1459	type II secretion system
C1A23_RS22505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1A23_RS22515	COG3031	protein transport across the cell outer membrane
C1A23_RS22525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C1A23_RS22530	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C1A23_RS22555	COG3133	Outer membrane lipoprotein
C1A23_RS22570	COG2771	luxR family
C1A23_RS22575	COG3916	Acyl-homoserine-lactone synthase
C1A23_RS22585	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C1A23_RS22590	COG1309	transcriptional regulator
C1A23_RS22600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A23_RS22600	COG2213	PTS system mannitol-specific
C1A23_RS22605	COG0246	Mannitol dehydrogenase
C1A23_RS22610	COG3722	fumarate hydratase activity
C1A23_RS22615	COG3263	regulation of cellular component size
C1A23_RS22640	COG1671	Belongs to the UPF0178 family
C1A23_RS22655	COG1988	membrane-bound metal-dependent
C1A23_RS22660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C1A23_RS22665	COG0513	Belongs to the DEAD box helicase family
C1A23_RS22690	COG1575	Belongs to the MenA family. Type 1 subfamily
C1A23_RS22695	COG1169	isochorismate synthase
C1A23_RS22700	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1A23_RS22705	COG0596	Alpha beta hydrolase
C1A23_RS22710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1A23_RS22715	COG1441	menaquinone biosynthetic process
C1A23_RS22720	COG0318	PFAM AMP-dependent synthetase and ligase
C1A23_RS22735	COG3539	Fimbrial protein
C1A23_RS22740	COG3121	Chaperone
C1A23_RS22745	COG3188	usher protein
C1A23_RS22755	COG3539	Fimbrial protein
C1A23_RS22760	COG3039	Transposase
C1A23_RS22775	COG3291	Pkd domain containing protein
C1A23_RS22780	COG2949	membrane
C1A23_RS22785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1A23_RS22800	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C1A23_RS22805	COG5380	lipid catabolic process
C1A23_RS22820	COG4533	DNA binding
C1A23_RS22830	COG2873	o-acetylhomoserine
C1A23_RS22840	COG1979	alcohol dehydrogenase
C1A23_RS22860	COG4221	oxidoreductase activity
C1A23_RS22880	COG1285	pathogenesis
C1A23_RS22900	COG1368	sulfuric ester hydrolase activity
C1A23_RS22905	COG1522	sequence-specific DNA binding
C1A23_RS22915	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C1A23_RS22920	COG1418	mRNA catabolic process
C1A23_RS22925	COG1058	Belongs to the CinA family
C1A23_RS22925	COG1546	Belongs to the CinA family
C1A23_RS22935	COG0842	Transport permease protein
C1A23_RS22935	COG1129	ABC transporter
C1A23_RS22950	COG0561	phosphatase activity
C1A23_RS22955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1A23_RS22975	COG1011	Hydrolase
C1A23_RS22990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1A23_RS22995	COG0019	diaminopimelate decarboxylase activity
C1A23_RS23005	COG1965	Belongs to the frataxin family
C1A23_RS23010	COG0400	carboxylic ester hydrolase activity
C1A23_RS23015	COG3072	Adenylate cyclase
C1A23_RS23020	COG0181	hydroxymethylbilane synthase activity
C1A23_RS23030	COG2959	enzyme of heme biosynthesis
C1A23_RS23045	COG1494	fructose-1,6-bisphosphatase
C1A23_RS23095	COG1733	regulation of RNA biosynthetic process
C1A23_RS23115	COG3932	Exopolysaccharide synthesis, ExoD
C1A23_RS23120	COG0814	amino acid
C1A23_RS23125	COG3706	GGDEF domain
C1A23_RS23140	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C1A23_RS23145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1A23_RS23150	COG5433	transposase activity
C1A23_RS23160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C1A23_RS23165	COG2022	thiamine diphosphate biosynthetic process
C1A23_RS23175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C1A23_RS23180	COG0352	thiamine-phosphate diphosphorylase activity
C1A23_RS23185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C1A23_RS23210	COG0745	RESPONSE REGULATOR receiver
C1A23_RS23215	COG0642	Histidine kinase
C1A23_RS23225	COG0189	ligase activity
C1A23_RS23250	COG1639	'signal transduction protein
C1A23_RS23260	COG2321	neutral zinc metallopeptidase
C1A23_RS23265	COG3700	Belongs to the class B bacterial acid phosphatase family
C1A23_RS23285	COG1366	Belongs to the anti-sigma-factor antagonist family
C1A23_RS23290	COG2172	sigma factor antagonist activity
C1A23_RS23295	COG5002	protein histidine kinase activity
C1A23_RS23295	COG0784	Response regulator, receiver
C1A23_RS23295	COG2205	protein histidine kinase activity
C1A23_RS23300	COG3437	response regulator, receiver
C1A23_RS23310	COG0477	Major facilitator Superfamily
C1A23_RS23330	COG5433	transposase activity
C1A23_RS23340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1A23_RS23340	COG1263	PTS System
C1A23_RS23350	COG5433	transposase activity
C1A23_RS23370	COG0312	modulator of DNA gyrase
C1A23_RS23375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1A23_RS23385	COG3164	Protein of unknown function
C1A23_RS23390	COG1530	ribonuclease E activity
C1A23_RS23395	COG0424	maF-like protein
C1A23_RS23400	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C1A23_RS23405	COG1792	Involved in formation and maintenance of cell shape
C1A23_RS23410	COG1077	Cell shape determining protein MreB Mrl
C1A23_RS23440	COG2165	general secretion pathway protein
C1A23_RS23445	COG2165	general secretion pathway protein
C1A23_RS23455	COG1459	type II secretion system
C1A23_RS23460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1A23_RS23505	COG2199	diguanylate cyclase activity
C1A23_RS23505	COG2200	EAL domain
C1A23_RS23510	COG2200	EAL domain
C1A23_RS23520	COG2986	histidine ammonia-lyase
C1A23_RS23525	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1A23_RS23530	COG0010	Belongs to the arginase family
C1A23_RS23535	COG1228	amidohydrolase
C1A23_RS23540	COG2188	Transcriptional regulator
C1A23_RS23545	COG0288	reversible hydration of carbon dioxide
C1A23_RS23560	COG2177	Part of the ABC transporter FtsEX involved in
C1A23_RS23565	COG2884	Cell division ATP-binding protein ftsE
C1A23_RS23570	COG0552	protein localization to endoplasmic reticulum
C1A23_RS23575	COG0742	ribosomal rna small subunit methyltransferase
C1A23_RS23605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1A23_RS23610	COG0741	lytic transglycosylase activity
C1A23_RS23620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1A23_RS23630	COG2095	MarC family integral membrane protein
C1A23_RS23640	COG1301	dicarboxylic acid transport
C1A23_RS23665	COG3714	YhhN family
C1A23_RS23690	COG1770	oligopeptidase
C1A23_RS23705	COG4221	oxidoreductase activity
C1A23_RS23710	COG0583	DNA-binding transcription factor activity
C1A23_RS23715	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1A23_RS23735	COG4584	PFAM Integrase catalytic
C1A23_RS23740	COG1484	DNA-dependent DNA replication
C1A23_RS23785	COG0203	ribosomal protein L17
C1A23_RS23790	COG0202	RNA polymerase activity
C1A23_RS23795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1A23_RS23800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1A23_RS23805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1A23_RS23810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1A23_RS23815	COG0201	protein transport
C1A23_RS23820	COG0200	Binds to the 23S rRNA
C1A23_RS23825	COG1841	ribosomal large subunit assembly
C1A23_RS23830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1A23_RS23835	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1A23_RS23840	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1A23_RS23845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1A23_RS23850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1A23_RS23855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1A23_RS23860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1A23_RS23865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1A23_RS23870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1A23_RS23875	COG0255	Belongs to the universal ribosomal protein uL29 family
C1A23_RS23880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1A23_RS23885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1A23_RS23890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1A23_RS23895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1A23_RS23900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1A23_RS23905	COG0089	rRNA binding
C1A23_RS23910	COG0088	Forms part of the polypeptide exit tunnel
C1A23_RS23915	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1A23_RS23920	COG0051	transcription antitermination factor activity, RNA binding
C1A23_RS23940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1A23_RS23945	COG2183	response to ionizing radiation
C1A23_RS23965	COG0596	Alpha beta hydrolase
C1A23_RS23970	COG1040	competence protein
C1A23_RS23975	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1A23_RS23975	COG0316	Belongs to the HesB IscA family
C1A23_RS23980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1A23_RS23985	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C1A23_RS23990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1A23_RS23995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C1A23_RS24000	COG4942	peptidase
C1A23_RS24010	COG1609	Transcriptional regulator
C1A23_RS24015	COG0800	Aldolase
C1A23_RS24020	COG0129	dihydroxy-acid dehydratase activity
C1A23_RS24025	COG3265	gluconokinase activity
C1A23_RS24030	COG2610	gluconate transmembrane transporter activity
C1A23_RS24035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1A23_RS24040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1A23_RS24050	COG0456	acetyltransferase
C1A23_RS24060	COG1490	D-aminoacyl-tRNA deacylase activity
C1A23_RS24065	COG1295	ribonuclease BN
C1A23_RS24070	COG1295	ribonuclease BN
C1A23_RS24075	COG1217	gtp-binding protein TYPA
C1A23_RS24080	COG0174	glutamine synthetase
C1A23_RS24090	COG3852	Histidine kinase
C1A23_RS24095	COG2204	response regulator
C1A23_RS24100	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1A23_RS24105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1A23_RS24115	COG3078	GTPase activator activity
C1A23_RS24130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1A23_RS24140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1A23_RS24145	COG0408	coproporphyrinogen oxidase activity
C1A23_RS24150	COG0009	L-threonylcarbamoyladenylate synthase
C1A23_RS24160	COG0551	DNA topoisomerase type I activity
C1A23_RS24165	COG2922	Belongs to the Smg family
C1A23_RS24170	COG0758	DNA mediated transformation
C1A23_RS24180	COG0242	peptide deformylase activity
C1A23_RS24185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1A23_RS24190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1A23_RS24190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1A23_RS24195	COG0569	domain protein
C1A23_RS24200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1A23_RS24205	COG1322	Protein conserved in bacteria
C1A23_RS24225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1A23_RS24230	COG0686	Belongs to the AlaDH PNT family
C1A23_RS24235	COG0519	Catalyzes the synthesis of GMP from XMP
C1A23_RS24235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1A23_RS24245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1A23_RS24250	COG1396	sequence-specific DNA binding
C1A23_RS24255	COG1012	belongs to the aldehyde dehydrogenase family
C1A23_RS24265	COG2962	Rard protein
C1A23_RS24275	COG1280	lysine exporter protein (LysE YggA)
C1A23_RS24290	COG2391	methyltransferase activity
C1A23_RS24295	COG1280	lysine exporter protein (LysE YggA)
C1A23_RS24345	COG1943	Transposase
C1A23_RS24360	COG0210	DNA helicase
C1A23_RS24375	COG1744	ABC transporter substrate-binding protein PnrA-like
C1A23_RS24380	COG3845	ABC transporter
C1A23_RS24385	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1A23_RS24390	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1A23_RS24395	COG0583	DNA-binding transcription factor activity
C1A23_RS24415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1A23_RS24420	COG0385	Bile acid
C1A23_RS24425	COG0531	amino acid
C1A23_RS24430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1A23_RS24435	COG0531	amino acid
C1A23_RS24440	COG2731	YhcH YjgK YiaL family protein
C1A23_RS24445	COG3250	beta-galactosidase activity
C1A23_RS24450	COG4584	PFAM Integrase catalytic
C1A23_RS24455	COG1484	DNA-dependent DNA replication
C1A23_RS24460	COG1609	Transcriptional regulator
C1A23_RS24500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C1A23_RS24505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1A23_RS24505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1A23_RS24515	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C1A23_RS24520	COG3074	FtsZ-dependent cytokinesis
C1A23_RS24530	COG1045	serine acetyltransferase
C1A23_RS24540	COG0745	RESPONSE REGULATOR receiver
C1A23_RS24545	COG2205	protein histidine kinase activity
C1A23_RS24550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1A23_RS24555	COG0534	Mate efflux family protein
C1A23_RS24580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1A23_RS24585	COG2937	Belongs to the GPAT DAPAT family
C1A23_RS24590	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1A23_RS24595	COG3161	chorismate lyase activity
C1A23_RS24600	COG1580	Controls the rotational direction of flagella during chemotaxis
C1A23_RS24620	COG0604	alcohol dehydrogenase
C1A23_RS24625	COG1609	Transcriptional regulator
C1A23_RS24645	COG1519	Transferase
C1A23_RS24650	COG0859	PFAM glycosyl transferase family 9
C1A23_RS24655	COG0463	Glycosyl transferase, family 2
C1A23_RS24660	COG0859	PFAM glycosyl transferase family 9
C1A23_RS24665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1A23_RS24670	COG2990	Protein conserved in bacteria
C1A23_RS24675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1A23_RS24685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1A23_RS24690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1A23_RS24695	COG2003	Belongs to the UPF0758 family
C1A23_RS24700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1A23_RS24705	COG0756	dUTP diphosphatase activity
C1A23_RS24710	COG1309	transcriptional regulator
C1A23_RS24715	COG0668	transmembrane transport
C1A23_RS24730	COG0166	Belongs to the GPI family
C1A23_RS24735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1A23_RS24740	COG0583	DNA-binding transcription factor activity
C1A23_RS24780	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C1A23_RS24785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1A23_RS24790	COG1739	Uncharacterized protein family UPF0029
C1A23_RS24795	COG0006	proline dipeptidase activity
C1A23_RS24800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1A23_RS24805	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1A23_RS24805	COG1024	Enoyl-CoA hydratase
C1A23_RS24810	COG0183	Belongs to the thiolase family
C1A23_RS24835	COG0425	Belongs to the sulfur carrier protein TusA family
C1A23_RS24840	COG0251	oxidation-reduction process
C1A23_RS24850	COG2885	chlorophyll binding
C1A23_RS24855	COG1335	isochorismatase
C1A23_RS24860	COG2818	Glycosylase
C1A23_RS24865	COG0752	glycyl-tRNA synthetase alpha subunit
C1A23_RS24870	COG0751	glycine-tRNA ligase activity
C1A23_RS24880	COG2046	Belongs to the sulfate adenylyltransferase family
C1A23_RS24880	COG0529	Catalyzes the synthesis of activated sulfate
C1A23_RS24895	COG0814	amino acid
C1A23_RS24900	COG0348	domain, Protein
C1A23_RS24910	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1A23_RS24915	COG0426	domain, Protein
C1A23_RS24915	COG1773	rubredoxin
C1A23_RS24920	COG3604	Transcriptional regulator
C1A23_RS24925	COG2188	Transcriptional regulator
C1A23_RS24940	COG1609	Transcriptional regulator
C1A23_RS24980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C1A23_RS25005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C1A23_RS25020	COG3118	belongs to the thioredoxin family
C1A23_RS25025	COG0513	Belongs to the DEAD box helicase family
C1A23_RS25030	COG0248	Ppx GppA phosphatase
C1A23_RS25045	COG0742	ribosomal rna small subunit methyltransferase
C1A23_RS25065	COG0084	hydrolase, TatD family'
C1A23_RS25070	COG0805	protein transport
C1A23_RS25075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1A23_RS25085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1A23_RS25090	COG3165	ubiquinone biosynthetic process from chorismate
C1A23_RS25100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1A23_RS25105	COG0402	S-adenosylhomocysteine deaminase activity
C1A23_RS25150	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C1A23_RS25155	COG0848	biopolymer transport protein
C1A23_RS25160	COG0811	peptide transport
C1A23_RS25165	COG0811	peptide transport
C1A23_RS25175	COG2771	luxR family
C1A23_RS25180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1A23_RS25185	COG1349	DNA-binding transcription factor activity
C1A23_RS25190	COG0745	RESPONSE REGULATOR receiver
C1A23_RS25195	COG2205	protein histidine kinase activity
C1A23_RS25210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1A23_RS25215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1A23_RS25220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1A23_RS25225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1A23_RS25230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1A23_RS25235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1A23_RS25240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1A23_RS25250	COG0356	it plays a direct role in the translocation of protons across the membrane
C1A23_RS25260	COG1475	DNA binding
C1A23_RS25265	COG1192	Involved in chromosome partitioning
C1A23_RS25270	COG0357	Ribosomal RNA small subunit methyltransferase G
C1A23_RS25275	COG0445	tRNA wobble uridine modification
C1A23_RS25280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1A23_RS25285	COG4774	siderophore transport
C1A23_RS25290	COG4615	Cyclic peptide transporter
C1A23_RS25295	COG1120	ATPase activity
C1A23_RS25310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C1A23_RS25315	COG0706	membrane insertase activity
C1A23_RS25320	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1A23_RS25325	COG0594	ribonuclease P activity
C1A23_RS25330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1A23_RS25335	COG1126	abc transporter atp-binding protein