locus-tag	class	description
HQ398_RS00005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HQ398_RS00010	COG0473	3-isopropylmalate dehydrogenase activity
HQ398_RS00040	COG0028	Belongs to the TPP enzyme family
HQ398_RS00045	COG0440	acetolactate synthase activity
HQ398_RS00090	COG3311	Transcriptional regulator
HQ398_RS00105	COG3385	transposase activity
HQ398_RS00150	COG2003	Belongs to the UPF0758 family
HQ398_RS00185	COG5002	protein histidine kinase activity
HQ398_RS00195	COG0745	RESPONSE REGULATOR receiver
HQ398_RS00205	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HQ398_RS00220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_RS00250	COG0745	RESPONSE REGULATOR receiver
HQ398_RS00255	COG3104	oligopeptide transport
HQ398_RS00260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HQ398_RS00265	COG1555	photosystem II stabilization
HQ398_RS00270	COG0857	belongs to the CobB CobQ family
HQ398_RS00270	COG0280	phosphate acetyltransferase
HQ398_RS00275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HQ398_RS00285	COG3013	Belongs to the UPF0304 family
HQ398_RS00290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HQ398_RS00300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ398_RS00305	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HQ398_RS00310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HQ398_RS00345	COG0784	Response regulator, receiver
HQ398_RS00345	COG2198	Histidine kinase
HQ398_RS00345	COG5002	protein histidine kinase activity
HQ398_RS00380	COG1464	Belongs to the NlpA lipoprotein family
HQ398_RS00385	COG2011	ABC-type metal ion transport system permease component
HQ398_RS00390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HQ398_RS00410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HQ398_RS00410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HQ398_RS00415	COG0802	atpase or kinase
HQ398_RS00425	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HQ398_RS00430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HQ398_RS00435	COG1923	regulation of RNA biosynthetic process
HQ398_RS00440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HQ398_RS00445	COG0330	HflC and HflK could
HQ398_RS00450	COG0330	HflC and HflK could
HQ398_RS00455	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HQ398_RS00460	COG0142	geranyltranstransferase activity
HQ398_RS00465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HQ398_RS00470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HQ398_RS00475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HQ398_RS00480	COG3314	Sporulation integral membrane protein YlbJ
HQ398_RS00485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HQ398_RS00495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HQ398_RS00500	COG2967	ApaG domain
HQ398_RS00505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HQ398_RS00510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HQ398_RS00515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ398_RS00520	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HQ398_RS00525	COG3178	'Phosphotransferase
HQ398_RS00530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HQ398_RS00535	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HQ398_RS00540	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ398_RS00545	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HQ398_RS00550	COG1073	alpha beta
HQ398_RS00565	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HQ398_RS00580	COG4628	conserved protein (DUF2132)
HQ398_RS00585	COG0688	phosphatidylethanolamine metabolic process
HQ398_RS00590	COG1162	GTPase activity
HQ398_RS00595	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HQ398_RS00635	COG1278	Cold shock
HQ398_RS00645	COG0840	transmembrane signaling receptor activity
HQ398_RS00650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ398_RS00655	COG2252	PERMEase
HQ398_RS00665	COG0488	(ABC) transporter
HQ398_RS00670	COG0582	viral genome integration into host DNA
HQ398_RS00770	COG1846	Transcriptional regulator
HQ398_RS00870	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HQ398_RS00920	COG2771	luxR family
HQ398_RS00955	COG1802	Transcriptional regulator
HQ398_RS00955	COG4626	Terminase
HQ398_RS01010	COG4386	tail sheath protein
HQ398_RS01055	COG3299	homolog of phage Mu protein gp47
HQ398_RS01060	COG3778	Protein conserved in bacteria
HQ398_RS01095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HQ398_RS01100	COG0741	lytic transglycosylase activity
HQ398_RS01110	COG3416	Protein conserved in bacteria
HQ398_RS01135	COG4608	Belongs to the ABC transporter superfamily
HQ398_RS01140	COG0444	Belongs to the ABC transporter superfamily
HQ398_RS01145	COG4239	(ABC) transporter, permease
HQ398_RS01150	COG4174	ABC transporter (Permease)
HQ398_RS01165	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ398_RS01165	COG1902	pentaerythritol trinitrate reductase activity
HQ398_RS01170	COG0778	Nitroreductase
HQ398_RS01175	COG0110	maltose O-acetyltransferase activity
HQ398_RS01180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ398_RS01185	COG2264	protein methyltransferase activity
HQ398_RS01190	COG0604	alcohol dehydrogenase
HQ398_RS01195	COG0583	DNA-binding transcription factor activity
HQ398_RS01200	COG1263	PTS System
HQ398_RS01200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_RS01200	COG2190	(PTS) system
HQ398_RS01205	COG4145	pantothenate transmembrane transporter activity
HQ398_RS01210	COG3924	membrane
HQ398_RS01215	COG0439	Biotin carboxylase
HQ398_RS01220	COG0511	ligase activity, forming carbon-carbon bonds
HQ398_RS01225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HQ398_RS01230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HQ398_RS01245	COG3385	transposase activity
HQ398_RS01260	COG3381	protein complex oligomerization
HQ398_RS01275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HQ398_RS01285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HQ398_RS01290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQ398_RS01290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQ398_RS01310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ398_RS01315	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HQ398_RS01320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HQ398_RS01330	COG4166	transmembrane transport
HQ398_RS01335	COG0601	transmembrane transport
HQ398_RS01345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HQ398_RS01350	COG0142	geranyltranstransferase activity
HQ398_RS01355	COG1722	exodeoxyribonuclease VII activity
HQ398_RS01360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ398_RS01365	COG1360	Flagellar Motor Protein
HQ398_RS01365	COG1360	Flagellar Motor Protein
HQ398_RS01380	COG1534	Rna-binding protein
HQ398_RS01385	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HQ398_RS01395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HQ398_RS01400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HQ398_RS01405	COG0149	triose-phosphate isomerase activity
HQ398_RS01410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HQ398_RS01425	COG0779	Required for maturation of 30S ribosomal subunits
HQ398_RS01430	COG0195	Participates in both transcription termination and antitermination
HQ398_RS01435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HQ398_RS01440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HQ398_RS01445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HQ398_RS01450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HQ398_RS01455	COG1185	polyribonucleotide nucleotidyltransferase activity
HQ398_RS01460	COG2201	protein-glutamate methylesterase activity
HQ398_RS01465	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HQ398_RS01490	COG0643	Histidine kinase
HQ398_RS01490	COG2198	Histidine kinase
HQ398_RS01500	COG0745	RESPONSE REGULATOR receiver
HQ398_RS01510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ398_RS01525	COG0826	peptidase U32
HQ398_RS01530	COG3385	transposase activity
HQ398_RS01535	COG0737	Belongs to the 5'-nucleotidase family
HQ398_RS01555	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HQ398_RS01580	COG0300	oxidoreductase activity
HQ398_RS01625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ398_RS01670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HQ398_RS01680	COG2003	Belongs to the UPF0758 family
HQ398_RS01725	COG5377	YqaJ viral recombinase family
HQ398_RS01755	COG1605	Chorismate mutase
HQ398_RS01755	COG0077	Prephenate dehydratase
HQ398_RS01785	COG3272	Protein of unknown function (DUF1722)
HQ398_RS01790	COG0789	Transcriptional regulator
HQ398_RS01795	COG0415	Belongs to the DNA photolyase family
HQ398_RS01805	COG0300	oxidoreductase activity
HQ398_RS01820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HQ398_RS01850	COG1477	protein flavinylation
HQ398_RS01855	COG2871	sodium ion transport
HQ398_RS01860	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ398_RS01865	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ398_RS01870	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ398_RS01875	COG1805	sodium ion transport
HQ398_RS01880	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ398_RS01885	COG0271	Belongs to the BolA IbaG family
HQ398_RS01890	COG2813	Specifically methylates the guanine in position
HQ398_RS01900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQ398_RS01915	COG1666	GTP binding
HQ398_RS01920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HQ398_RS01935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ398_RS01940	COG0840	transmembrane signaling receptor activity
HQ398_RS01945	COG0583	DNA-binding transcription factor activity
HQ398_RS01955	COG2363	Small membrane protein
HQ398_RS01960	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HQ398_RS01970	COG0473	3-isopropylmalate dehydrogenase activity
HQ398_RS01975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQ398_RS01980	COG1611	Belongs to the LOG family
HQ398_RS01995	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HQ398_RS01995	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HQ398_RS02005	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HQ398_RS02030	COG3098	single-species biofilm formation
HQ398_RS02035	COG0564	pseudouridine synthase activity
HQ398_RS02050	COG3385	transposase activity
HQ398_RS02065	COG1263	PTS System
HQ398_RS02065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_RS02075	COG2171	N-acyltransferase activity
HQ398_RS02085	COG0024	Methionine aminopeptidase
HQ398_RS02090	COG0052	Belongs to the universal ribosomal protein uS2 family
HQ398_RS02095	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HQ398_RS02100	COG0528	UMP kinase activity
HQ398_RS02105	COG0233	cytoplasmic translational termination
HQ398_RS02110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HQ398_RS02115	COG0575	Belongs to the CDS family
HQ398_RS02120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HQ398_RS02125	COG0750	zinc metalloprotease
HQ398_RS02130	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ398_RS02140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ398_RS02145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ398_RS02150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ398_RS02155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ398_RS02160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HQ398_RS02170	COG0825	malonyl-CoA metabolic process
HQ398_RS02180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQ398_RS02185	COG1115	amino acid carrier protein
HQ398_RS02235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HQ398_RS02240	COG1678	Uncharacterized ACR, COG1678
HQ398_RS02250	COG0189	ligase activity
HQ398_RS02255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HQ398_RS02265	COG3091	SprT-like family
HQ398_RS02275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HQ398_RS02290	COG3385	transposase activity
HQ398_RS02305	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HQ398_RS02310	COG0739	heme binding
HQ398_RS02315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HQ398_RS02345	COG0814	amino acid
HQ398_RS02375	COG0488	(ABC) transporter
HQ398_RS02380	COG3710	Transcriptional regulator
HQ398_RS02385	COG0531	amino acid
HQ398_RS02390	COG1982	Orn Lys Arg decarboxylase major
HQ398_RS02395	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HQ398_RS02405	COG3590	peptidase
HQ398_RS02415	COG2199	diguanylate cyclase activity
HQ398_RS02415	COG2203	Gaf domain
HQ398_RS02450	COG0366	Alpha amylase catalytic
HQ398_RS02465	COG0463	Glycosyl transferase, family 2
HQ398_RS02480	COG2989	Protein conserved in bacteria
HQ398_RS02485	COG3108	Peptidase M15
HQ398_RS02495	COG2860	membrane
HQ398_RS02505	COG1196	nuclear chromosome segregation
HQ398_RS02510	COG3115	cell septum assembly
HQ398_RS02515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HQ398_RS02525	COG1328	CTP reductase activity
HQ398_RS02530	COG0602	queuosine metabolic process
HQ398_RS02575	COG0281	malic enzyme
HQ398_RS02580	COG3290	protein histidine kinase activity
HQ398_RS02590	COG0697	spore germination
HQ398_RS02600	COG3706	GGDEF domain
HQ398_RS02605	COG0346	lactoylglutathione lyase activity
HQ398_RS02610	COG0745	RESPONSE REGULATOR receiver
HQ398_RS02615	COG5002	protein histidine kinase activity
HQ398_RS02640	COG3142	Participates in the control of copper homeostasis
HQ398_RS02645	COG0545	Peptidyl-prolyl cis-trans isomerase
HQ398_RS02660	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HQ398_RS02680	COG0019	diaminopimelate decarboxylase activity
HQ398_RS02685	COG1115	amino acid carrier protein
HQ398_RS02705	COG0534	Mate efflux family protein
HQ398_RS02715	COG0281	malic enzyme
HQ398_RS02725	COG2885	chlorophyll binding
HQ398_RS02725	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HQ398_RS02745	COG0733	neurotransmitter:sodium symporter activity
HQ398_RS02750	COG1752	Esterase of the alpha-beta hydrolase superfamily
HQ398_RS02755	COG3706	GGDEF domain
HQ398_RS02760	COG1566	PFAM secretion protein HlyD family protein
HQ398_RS02770	COG1032	radical SAM domain protein
HQ398_RS02805	COG0583	DNA-binding transcription factor activity
HQ398_RS02815	COG0673	inositol 2-dehydrogenase activity
HQ398_RS02820	COG2920	part of a sulfur-relay system
HQ398_RS02825	COG1289	transmembrane transporter activity
HQ398_RS02830	COG0670	Belongs to the BI1 family
HQ398_RS02845	COG1486	melibiose metabolic process
HQ398_RS02850	COG1917	Cupin 2, conserved barrel domain protein
HQ398_RS02850	COG2169	Transcriptional regulator
HQ398_RS02855	COG1447	Phosphotransferase system cellobiose-specific component IIA
HQ398_RS02860	COG2723	6-phospho-beta-galactosidase activity
HQ398_RS02865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HQ398_RS02870	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HQ398_RS02880	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HQ398_RS02890	COG3156	type II secretion system protein K
HQ398_RS02895	COG4795	General secretion pathway protein
HQ398_RS02900	COG2165	general secretion pathway protein
HQ398_RS02910	COG2165	general secretion pathway protein
HQ398_RS02915	COG1459	type II secretion system
HQ398_RS02920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ398_RS02930	COG3031	protein transport across the cell outer membrane
HQ398_RS02940	COG3267	Type II secretory pathway component ExeA
HQ398_RS02940	COG3409	Peptidoglycan-binding domain 1 protein
HQ398_RS02945	COG2770	Histidine kinase
HQ398_RS02945	COG3437	response regulator, receiver
HQ398_RS02960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HQ398_RS02965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HQ398_RS02970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS02980	COG2190	(PTS) system
HQ398_RS02985	COG3706	GGDEF domain
HQ398_RS02990	COG1196	nuclear chromosome segregation
HQ398_RS02990	COG3264	Mechanosensitive ion channel
HQ398_RS02995	COG0469	pyruvate kinase activity
HQ398_RS03005	COG3384	dioxygenase
HQ398_RS03010	COG0419	ATPase involved in DNA repair
HQ398_RS03015	COG0420	3'-5' exonuclease activity
HQ398_RS03025	COG2974	May be involved in recombination
HQ398_RS03035	COG1283	sodium-dependent phosphate transmembrane transporter activity
HQ398_RS03045	COG0531	amino acid
HQ398_RS03055	COG0531	amino acid
HQ398_RS03070	COG1396	sequence-specific DNA binding
HQ398_RS03070	COG1917	Cupin 2, conserved barrel domain protein
HQ398_RS03075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ398_RS03100	COG3152	Membrane
HQ398_RS03105	COG3385	transposase activity
HQ398_RS03110	COG3161	chorismate lyase activity
HQ398_RS03155	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HQ398_RS03160	COG4988	ABC transporter
HQ398_RS03175	COG0745	RESPONSE REGULATOR receiver
HQ398_RS03185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HQ398_RS03200	COG0640	Transcriptional regulator
HQ398_RS03205	COG0798	PFAM Bile acid sodium symporter
HQ398_RS03215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ398_RS03220	COG1988	membrane-bound metal-dependent
HQ398_RS03230	COG3385	transposase activity
HQ398_RS03240	COG0159	tryptophan synthase activity
HQ398_RS03245	COG0133	tryptophan synthase activity
HQ398_RS03250	COG0134	indole-3-glycerol-phosphate synthase activity
HQ398_RS03250	COG0135	phosphoribosylanthranilate isomerase activity
HQ398_RS03255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQ398_RS03260	COG0512	Glutamine amidotransferase of anthranilate synthase
HQ398_RS03260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQ398_RS03265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HQ398_RS03275	COG0009	L-threonylcarbamoyladenylate synthase
HQ398_RS03285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HQ398_RS03300	COG3210	domain, Protein
HQ398_RS03325	COG1993	acr, cog1993
HQ398_RS03340	COG1946	Acyl-CoA thioesterase
HQ398_RS03345	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HQ398_RS03350	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HQ398_RS03365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HQ398_RS03385	COG0813	purine-nucleoside phosphorylase activity
HQ398_RS03410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQ398_RS03435	COG1309	transcriptional regulator
HQ398_RS03440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_RS03455	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HQ398_RS03480	COG1216	Glycosyl transferase, family 2
HQ398_RS03495	COG3594	Acyltransferase
HQ398_RS03510	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HQ398_RS03515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ398_RS03540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQ398_RS03545	COG1091	dTDP-4-dehydrorhamnose reductase activity
HQ398_RS03565	COG3385	transposase activity
HQ398_RS03570	COG1538	Outer membrane efflux protein
HQ398_RS03575	COG0577	efflux transmembrane transporter activity
HQ398_RS03575	COG1136	(ABC) transporter
HQ398_RS03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_RS03585	COG1227	inorganic diphosphatase activity
HQ398_RS03590	COG0497	DNA recombination
HQ398_RS03595	COG1486	melibiose metabolic process
HQ398_RS03600	COG0583	DNA-binding transcription factor activity
HQ398_RS03605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HQ398_RS03610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HQ398_RS03615	COG0443	Heat shock 70 kDa protein
HQ398_RS03620	COG0484	heat shock protein binding
HQ398_RS03665	COG5001	Diguanylate cyclase
HQ398_RS03670	COG0095	Lipoate-protein ligase
HQ398_RS03680	COG0702	epimerase
HQ398_RS03685	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ398_RS03690	COG1454	alcohol dehydrogenase
HQ398_RS03700	COG0564	pseudouridine synthase activity
HQ398_RS03705	COG1957	nucleoside hydrolase
HQ398_RS03735	COG1280	lysine exporter protein (LysE YggA)
HQ398_RS03740	COG3263	regulation of cellular component size
HQ398_RS03750	COG3263	regulation of cellular component size
HQ398_RS03760	COG1876	peptidase activity
HQ398_RS03765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQ398_RS03770	COG1393	Belongs to the ArsC family
HQ398_RS03780	COG3385	transposase activity
HQ398_RS03785	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ398_RS03790	COG1473	amidohydrolase
HQ398_RS03800	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HQ398_RS03810	COG0017	Asparaginyl-tRNA synthetase
HQ398_RS03825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HQ398_RS03830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQ398_RS03835	COG0156	8-amino-7-oxononanoate synthase activity
HQ398_RS03840	COG1073	alpha beta
HQ398_RS03840	COG2226	methyltransferase
HQ398_RS03845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HQ398_RS03850	COG0501	Belongs to the peptidase M48B family
HQ398_RS03855	COG3217	Mosc domain protein beta barrel domain protein
HQ398_RS03855	COG0633	Ferredoxin
HQ398_RS03855	COG3217	Mosc domain protein beta barrel domain protein
HQ398_RS03855	COG0633	Ferredoxin
HQ398_RS03865	COG0674	pyruvate-flavodoxin oxidoreductase activity
HQ398_RS03865	COG1013	pyruvate-flavodoxin oxidoreductase activity
HQ398_RS03865	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HQ398_RS03865	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HQ398_RS03875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ398_RS03880	COG1607	acyl-coa hydrolase
HQ398_RS03890	COG3021	interspecies interaction between organisms
HQ398_RS03895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HQ398_RS03900	COG2027	D-alanyl-D-alanine carboxypeptidase
HQ398_RS03905	COG1061	Type III restriction enzyme res subunit
HQ398_RS03910	COG1566	PFAM secretion protein HlyD family protein
HQ398_RS03920	COG1966	Carbon starvation protein
HQ398_RS03925	COG3279	Response regulator of the LytR AlgR family
HQ398_RS03935	COG2199	diguanylate cyclase activity
HQ398_RS03935	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ398_RS03945	COG1940	carbohydrate kinase activity
HQ398_RS03945	COG1846	Transcriptional regulator
HQ398_RS03950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ398_RS03955	COG0363	glucosamine-6-phosphate deaminase activity
HQ398_RS03960	COG1263	PTS System
HQ398_RS03960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_RS03960	COG2190	(PTS) system
HQ398_RS03970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ398_RS03975	COG0735	belongs to the Fur family
HQ398_RS03985	COG0716	FMN binding
HQ398_RS04005	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HQ398_RS04010	COG0033	Phosphoglucomutase
HQ398_RS04015	COG2951	lytic endotransglycosylase activity
HQ398_RS04020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HQ398_RS04025	COG4136	ATPase activity
HQ398_RS04035	COG4134	Bacterial extracellular solute-binding protein
HQ398_RS04045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HQ398_RS04055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ398_RS04065	COG0729	surface antigen
HQ398_RS04090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HQ398_RS04100	COG0741	lytic transglycosylase activity
HQ398_RS04110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ398_RS04115	COG4771	TonB-dependent receptor
HQ398_RS04120	COG1169	isochorismate synthase
HQ398_RS04125	COG1021	2,3-dihydroxybenzoate-AMP ligase
HQ398_RS04130	COG1535	isochorismatase
HQ398_RS04130	COG3433	isochorismatase activity
HQ398_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
HQ398_RS04165	COG1278	Cold shock
HQ398_RS04200	COG1349	DNA-binding transcription factor activity
HQ398_RS04205	COG1882	Formate acetyltransferase
HQ398_RS04210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ398_RS04215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQ398_RS04240	COG4166	transmembrane transport
HQ398_RS04245	COG0622	Phosphoesterase
HQ398_RS04260	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HQ398_RS04265	COG0835	chemotaxis
HQ398_RS04265	COG0784	Response regulator, receiver
HQ398_RS04270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HQ398_RS04275	COG1815	bacterial-type flagellum-dependent cell motility
HQ398_RS04285	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HQ398_RS04295	COG4787	bacterial-type flagellum-dependent cell motility
HQ398_RS04305	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HQ398_RS04310	COG1706	bacterial-type flagellum-dependent cell motility
HQ398_RS04315	COG1705	Flagellar rod assembly protein muramidase FlgJ
HQ398_RS04315	COG3951	Flagellar rod assembly protein muramidase FlgJ
HQ398_RS04330	COG2239	Acts as a magnesium transporter
HQ398_RS04340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HQ398_RS04345	COG2716	regulation of RNA biosynthetic process
HQ398_RS04370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HQ398_RS04375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HQ398_RS04380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HQ398_RS04385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HQ398_RS04405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HQ398_RS04425	COG0590	tRNA wobble adenosine to inosine editing
HQ398_RS04430	COG0573	inorganic phosphate transmembrane transporter activity
HQ398_RS04435	COG0581	inorganic phosphate transmembrane transporter activity
HQ398_RS04440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HQ398_RS04445	COG0704	Plays a role in the regulation of phosphate uptake
HQ398_RS04450	COG1253	flavin adenine dinucleotide binding
HQ398_RS04470	COG1126	abc transporter atp-binding protein
HQ398_RS04475	COG0765	amino acid transport
HQ398_RS04480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_RS04485	COG2199	diguanylate cyclase activity
HQ398_RS04485	COG2203	Gaf domain
HQ398_RS04500	COG2197	response regulator
HQ398_RS04505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HQ398_RS04530	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HQ398_RS04535	COG0477	Major facilitator Superfamily
HQ398_RS04540	COG0123	including yeast histone deacetylase and acetoin utilization protein
HQ398_RS04550	COG1199	ATP-dependent helicase activity
HQ398_RS04560	COG1605	Chorismate mutase
HQ398_RS04560	COG0287	Prephenate dehydrogenase
HQ398_RS04565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ398_RS04575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ398_RS04580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ398_RS04615	COG0537	adenosine 5'-monophosphoramidase activity
HQ398_RS04630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HQ398_RS04645	COG1301	dicarboxylic acid transport
HQ398_RS04660	COG1164	Oligoendopeptidase f
HQ398_RS04665	COG2233	PERMEase
HQ398_RS04670	COG3150	esterase
HQ398_RS04675	COG1252	NADH dehydrogenase
HQ398_RS04685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ398_RS04695	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ398_RS04710	COG4953	penicillin-binding protein 1C
HQ398_RS04720	COG0301	tRNA thio-modification
HQ398_RS04720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ398_RS04735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ398_RS04780	COG2089	acid synthase
HQ398_RS04790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQ398_RS04795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HQ398_RS04805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HQ398_RS04810	COG1086	Polysaccharide biosynthesis protein
HQ398_RS04815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HQ398_RS04825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HQ398_RS04840	COG0483	inositol monophosphate 1-phosphatase activity
HQ398_RS04850	COG0625	glutathione transferase activity
HQ398_RS04855	COG2814	Major facilitator Superfamily
HQ398_RS04865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HQ398_RS04870	COG0243	molybdopterin cofactor binding
HQ398_RS04890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ398_RS04895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ398_RS04900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HQ398_RS04905	COG0509	glycine decarboxylation via glycine cleavage system
HQ398_RS04910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HQ398_RS04910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HQ398_RS04920	COG5642	Protein of unknown function (DUF2384)
HQ398_RS04940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HQ398_RS04950	COG0840	transmembrane signaling receptor activity
HQ398_RS04975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HQ398_RS04980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HQ398_RS04980	COG0574	Belongs to the PEP-utilizing enzyme family
HQ398_RS04995	COG1464	Belongs to the NlpA lipoprotein family
HQ398_RS05000	COG3083	sulfuric ester hydrolase activity
HQ398_RS05005	COG3082	Protein of unknown function (DUF1414)
HQ398_RS05010	COG3081	Nucleoid-associated protein
HQ398_RS05020	COG1175	transmembrane transport
HQ398_RS05025	COG3833	ABC-type maltose transport systems, permease component
HQ398_RS05030	COG3842	ATPase activity
HQ398_RS05055	COG0425	Belongs to the sulfur carrier protein TusA family
HQ398_RS05060	COG4783	chaperone-mediated protein folding
HQ398_RS05070	COG1393	Belongs to the ArsC family
HQ398_RS05085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ398_RS05090	COG2431	L-lysine efflux transmembrane transporter activity
HQ398_RS05110	COG4160	amino acid transport
HQ398_RS05115	COG0564	pseudouridine synthase activity
HQ398_RS05140	COG0625	glutathione transferase activity
HQ398_RS05145	COG0367	asparagine synthase
HQ398_RS05155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HQ398_RS05155	COG4651	solute:proton antiporter activity
HQ398_RS05160	COG0647	UMP catabolic process
HQ398_RS05175	COG1902	pentaerythritol trinitrate reductase activity
HQ398_RS05190	COG0247	lactate metabolic process
HQ398_RS05190	COG0277	FAD linked oxidase domain protein
HQ398_RS05200	COG2050	protein possibly involved in aromatic compounds catabolism
HQ398_RS05215	COG3300	MHYT domain
HQ398_RS05215	COG5001	Diguanylate cyclase
HQ398_RS05220	COG2056	Na+-H+ antiporter family
HQ398_RS05225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HQ398_RS05230	COG0671	phosphoesterase, PA-phosphatase related
HQ398_RS05240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HQ398_RS05250	COG0101	tRNA pseudouridine synthase activity
HQ398_RS05255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HQ398_RS05260	COG0285	dihydrofolate synthase activity
HQ398_RS05265	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HQ398_RS05270	COG0393	Putative heavy-metal-binding
HQ398_RS05280	COG1648	precorrin-2 dehydrogenase activity
HQ398_RS05280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQ398_RS05300	COG4667	esterase of the alpha-beta hydrolase superfamily
HQ398_RS05305	COG1619	proteins homologs of microcin C7 resistance protein MccF
HQ398_RS05310	COG1368	sulfuric ester hydrolase activity
HQ398_RS05320	COG0527	aspartate kinase activity
HQ398_RS05330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQ398_RS05350	COG0596	Alpha beta hydrolase
HQ398_RS05355	COG0840	transmembrane signaling receptor activity
HQ398_RS05390	COG0672	)-iron permease
HQ398_RS05410	COG0582	viral genome integration into host DNA
HQ398_RS05425	COG0659	secondary active sulfate transmembrane transporter activity
HQ398_RS05440	COG3501	Rhs element vgr protein
HQ398_RS05460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HQ398_RS05465	COG0326	Molecular chaperone. Has ATPase activity
HQ398_RS05470	COG4172	Belongs to the ABC transporter superfamily
HQ398_RS05500	COG1842	Phage shock protein A
HQ398_RS05520	COG3768	UPF0283 membrane protein
HQ398_RS05530	COG2154	pterin-4-alpha-carbinolamine dehydratase
HQ398_RS05545	COG2199	diguanylate cyclase activity
HQ398_RS05550	COG2885	chlorophyll binding
HQ398_RS05555	COG0861	Integral membrane protein TerC family
HQ398_RS05570	COG1022	Amp-dependent synthetase and ligase
HQ398_RS05585	COG2910	NAD(P)H-binding
HQ398_RS05590	COG0583	DNA-binding transcription factor activity
HQ398_RS05595	COG0583	DNA-binding transcription factor activity
HQ398_RS05600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HQ398_RS05615	COG0583	DNA-binding transcription factor activity
HQ398_RS05620	COG2723	6-phospho-beta-galactosidase activity
HQ398_RS05625	COG1944	ATP diphosphatase activity
HQ398_RS05630	COG2116	formate transmembrane transporter activity
HQ398_RS05635	COG1882	Formate acetyltransferase
HQ398_RS05640	COG2983	Belongs to the UPF0260 family
HQ398_RS05655	COG0058	SHG alpha-glucan phosphorylase activity
HQ398_RS05660	COG0471	metal ion transport
HQ398_RS05665	COG3118	belongs to the thioredoxin family
HQ398_RS05670	COG4999	Histidine kinase
HQ398_RS05670	COG2205	protein histidine kinase activity
HQ398_RS05670	COG3437	response regulator, receiver
HQ398_RS05670	COG3850	Histidine kinase
HQ398_RS05675	COG1132	(ABC) transporter
HQ398_RS05680	COG1132	(ABC) transporter
HQ398_RS05690	COG2501	S4 domain
HQ398_RS05705	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HQ398_RS05745	COG2009	succinate dehydrogenase
HQ398_RS05750	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HQ398_RS05755	COG1053	succinate dehydrogenase
HQ398_RS05765	COG0567	Dehydrogenase, E1 component
HQ398_RS05770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ398_RS05775	COG0045	succinate-CoA ligase (ADP-forming) activity
HQ398_RS05805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ398_RS05815	COG3842	ATPase activity
HQ398_RS05825	COG1840	ABC-type Fe3 transport system, periplasmic component
HQ398_RS05835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HQ398_RS05845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ398_RS05850	COG4235	cytochrome complex assembly
HQ398_RS05850	COG3088	subunit of a heme lyase
HQ398_RS05870	COG0437	4 iron, 4 sulfur cluster binding
HQ398_RS05875	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HQ398_RS05895	COG0247	lactate metabolic process
HQ398_RS05900	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HQ398_RS05905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HQ398_RS05920	COG0840	transmembrane signaling receptor activity
HQ398_RS05925	COG1940	carbohydrate kinase activity
HQ398_RS05925	COG1846	Transcriptional regulator
HQ398_RS05930	COG3148	PFAM DTW domain containing protein
HQ398_RS05935	COG0730	response to heat
HQ398_RS05940	COG0583	DNA-binding transcription factor activity
HQ398_RS05955	COG3593	DNA synthesis involved in DNA repair
HQ398_RS06000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ398_RS06005	COG1011	Hydrolase
HQ398_RS06020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HQ398_RS06025	COG2832	Protein of unknown function (DUF454)
HQ398_RS06030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HQ398_RS06040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HQ398_RS06055	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HQ398_RS06060	COG0583	DNA-binding transcription factor activity
HQ398_RS06070	COG1560	Kdo2-lipid A biosynthetic process
HQ398_RS06075	COG1560	Kdo2-lipid A biosynthetic process
HQ398_RS06095	COG0417	DNA replication proofreading
HQ398_RS06110	COG1451	nucleotide metabolic process
HQ398_RS06125	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ398_RS06140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ398_RS06140	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HQ398_RS06145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ398_RS06175	COG0586	Pfam SNARE associated Golgi protein
HQ398_RS06180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HQ398_RS06185	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQ398_RS06210	COG3829	transcription factor binding
HQ398_RS06240	COG0534	Mate efflux family protein
HQ398_RS06255	COG0307	riboflavin synthase, alpha
HQ398_RS06270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ398_RS06275	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HQ398_RS06280	COG0697	spore germination
HQ398_RS06285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HQ398_RS06325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HQ398_RS06330	COG3099	Belongs to the UPF0263 family
HQ398_RS06335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HQ398_RS06340	COG2894	cell division
HQ398_RS06345	COG0850	regulation of cytokinetic process
HQ398_RS06350	COG3100	YcgL domain-containing protein
HQ398_RS06355	COG3385	transposase activity
HQ398_RS06365	COG2824	Alkylphosphonate utilization operon protein PhnA
HQ398_RS06380	COG3791	Glutathione-dependent formaldehyde-activating
HQ398_RS06385	COG0406	alpha-ribazole phosphatase activity
HQ398_RS06390	COG3706	GGDEF domain
HQ398_RS06395	COG2840	Smr protein MutS2
HQ398_RS06400	COG2890	protein-(glutamine-N5) methyltransferase activity
HQ398_RS06405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HQ398_RS06415	COG0513	Belongs to the DEAD box helicase family
HQ398_RS06420	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HQ398_RS06435	COG0814	amino acid
HQ398_RS06440	COG1609	Transcriptional regulator
HQ398_RS06445	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS06445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS06450	COG1105	Belongs to the carbohydrate kinase PfkB family
HQ398_RS06455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_RS06455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_RS06455	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HQ398_RS06460	COG2140	Oxalate decarboxylase
HQ398_RS06465	COG1609	Transcriptional regulator
HQ398_RS06480	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_RS06480	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS06490	COG3716	PTS system mannose fructose sorbose family IID component
HQ398_RS06495	COG2942	2-epimerase
HQ398_RS06500	COG3313	Fe-S protein
HQ398_RS06505	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HQ398_RS06510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ398_RS06515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQ398_RS06520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQ398_RS06530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HQ398_RS06540	COG0366	Alpha amylase catalytic
HQ398_RS06560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HQ398_RS06565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HQ398_RS06570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HQ398_RS06575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HQ398_RS06580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HQ398_RS06585	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HQ398_RS06590	COG0072	phenylalanine-tRNA ligase activity
HQ398_RS06590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ398_RS06595	COG0776	regulation of translation
HQ398_RS06600	COG0784	Response regulator, receiver
HQ398_RS06600	COG2205	protein histidine kinase activity
HQ398_RS06620	COG1609	Transcriptional regulator
HQ398_RS06625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ398_RS06630	COG1879	ABC-type sugar transport system periplasmic component
HQ398_RS06635	COG1172	Belongs to the binding-protein-dependent transport system permease family
HQ398_RS06640	COG1129	ABC transporter
HQ398_RS06645	COG1869	D-ribose catabolic process
HQ398_RS06650	COG0625	glutathione transferase activity
HQ398_RS06660	COG1177	transmembrane transport
HQ398_RS06685	COG0037	tRNA processing
HQ398_RS06690	COG0589	response to stress
HQ398_RS06695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQ398_RS06720	COG2010	Cytochrome c
HQ398_RS06735	COG3278	Belongs to the heme-copper respiratory oxidase family
HQ398_RS06745	COG1956	GAF domain-containing protein
HQ398_RS06750	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HQ398_RS06760	COG0308	aminopeptidase N
HQ398_RS06770	COG2902	Dehydrogenase
HQ398_RS06775	COG0167	dihydroorotate dehydrogenase activity
HQ398_RS06805	COG2201	protein-glutamate methylesterase activity
HQ398_RS06815	COG0835	chemotaxis
HQ398_RS06840	COG0116	Belongs to the methyltransferase superfamily
HQ398_RS06840	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQ398_RS06850	COG0488	(ABC) transporter
HQ398_RS06860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ398_RS06865	COG1067	ATP-dependent peptidase activity
HQ398_RS06880	COG3141	response to X-ray
HQ398_RS06890	COG4221	oxidoreductase activity
HQ398_RS06915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HQ398_RS06935	COG0372	Belongs to the citrate synthase family
HQ398_RS06940	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HQ398_RS06950	COG2995	paraquat-inducible protein a
HQ398_RS06955	COG3008	intermembrane lipid transfer
HQ398_RS06960	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HQ398_RS06960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ398_RS06975	COG0084	hydrolase, TatD family'
HQ398_RS06980	COG0470	DNA polymerase III
HQ398_RS06985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HQ398_RS06990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HQ398_RS06995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HQ398_RS07005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ398_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
HQ398_RS07020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ398_RS07025	COG0416	fatty acid biosynthetic process
HQ398_RS07030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HQ398_RS07035	COG1399	metal-binding, possibly nucleic acid-binding protein
HQ398_RS07040	COG0424	maF-like protein
HQ398_RS07045	COG3385	transposase activity
HQ398_RS07060	COG1530	ribonuclease E activity
HQ398_RS07070	COG0306	phosphate transporter
HQ398_RS07075	COG0717	Belongs to the dCTP deaminase family
HQ398_RS07080	COG0572	uridine kinase
HQ398_RS07085	COG0489	protein tyrosine kinase activity
HQ398_RS07090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ398_RS07090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ398_RS07100	COG1254	Belongs to the acylphosphatase family
HQ398_RS07110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQ398_RS07120	COG0709	Synthesizes selenophosphate from selenide and ATP
HQ398_RS07125	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HQ398_RS07130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ398_RS07140	COG0318	PFAM AMP-dependent synthetase and ligase
HQ398_RS07145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HQ398_RS07155	COG1214	PFAM Peptidase M22, glycoprotease
HQ398_RS07160	COG1199	ATP-dependent helicase activity
HQ398_RS07170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HQ398_RS07175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HQ398_RS07180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HQ398_RS07185	COG0131	Imidazoleglycerol-phosphate dehydratase
HQ398_RS07185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HQ398_RS07190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HQ398_RS07195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HQ398_RS07200	COG0107	imidazoleglycerol-phosphate synthase activity
HQ398_RS07215	COG2199	diguanylate cyclase activity
HQ398_RS07225	COG1288	antiporter activity
HQ398_RS07235	COG3134	Outer membrane lipoprotein
HQ398_RS07240	COG2080	2 iron, 2 sulfur cluster binding
HQ398_RS07245	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HQ398_RS07250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HQ398_RS07260	COG2252	PERMEase
HQ398_RS07265	COG0402	S-adenosylhomocysteine deaminase activity
HQ398_RS07270	COG2233	PERMEase
HQ398_RS07275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HQ398_RS07275	COG2080	2 iron, 2 sulfur cluster binding
HQ398_RS07280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HQ398_RS07285	COG0402	S-adenosylhomocysteine deaminase activity
HQ398_RS07290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_RS07290	COG0493	'glutamate synthase
HQ398_RS07300	COG2068	MobA-Related Protein
HQ398_RS07305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HQ398_RS07310	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HQ398_RS07310	COG3608	succinylglutamate desuccinylase aspartoacylase
HQ398_RS07315	COG0697	spore germination
HQ398_RS07320	COG0549	Belongs to the carbamate kinase family
HQ398_RS07330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQ398_RS07335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HQ398_RS07340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HQ398_RS07365	COG0242	peptide deformylase activity
HQ398_RS07375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HQ398_RS07380	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HQ398_RS07385	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HQ398_RS07395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HQ398_RS07400	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HQ398_RS07410	COG0205	6-phosphofructokinase activity
HQ398_RS07415	COG1301	dicarboxylic acid transport
HQ398_RS07420	COG3123	guanosine phosphorylase activity
HQ398_RS07425	COG1760	l-serine dehydratase
HQ398_RS07430	COG1760	l-serine dehydratase
HQ398_RS07450	COG0814	amino acid
HQ398_RS07455	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HQ398_RS07460	COG0514	ATP-dependent DNA helicase (RecQ)
HQ398_RS07465	COG2766	serine protein kinase
HQ398_RS07470	COG2718	Belongs to the UPF0229 family
HQ398_RS07475	COG2719	SpoVR family
HQ398_RS07480	COG1024	Enoyl-CoA hydratase
HQ398_RS07480	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQ398_RS07485	COG0183	Belongs to the thiolase family
HQ398_RS07490	COG0714	Associated with various cellular activities
HQ398_RS07520	COG1595	DNA-templated transcription, initiation
HQ398_RS07530	COG2067	long-chain fatty acid transport protein
HQ398_RS07535	COG2067	long-chain fatty acid transport protein
HQ398_RS07540	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HQ398_RS07555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HQ398_RS07565	COG1643	Atp-dependent helicase
HQ398_RS07570	COG0517	IMP dehydrogenase activity
HQ398_RS07570	COG0617	tRNA 3'-terminal CCA addition
HQ398_RS07570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HQ398_RS07575	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ398_RS07580	COG2925	Exonuclease
HQ398_RS07590	COG3345	alpha-galactosidase
HQ398_RS07595	COG1380	Effector of murein hydrolase LrgA
HQ398_RS07600	COG1346	cytolysis
HQ398_RS07605	COG0295	cytidine deaminase activity
HQ398_RS07610	COG3033	Beta-eliminating lyase
HQ398_RS07620	COG3046	protein related to deoxyribodipyrimidine photolyase
HQ398_RS07630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HQ398_RS07655	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_RS07660	COG3385	transposase activity
HQ398_RS07675	COG0454	-acetyltransferase
HQ398_RS07680	COG3158	transport of potassium into the cell
HQ398_RS07685	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_RS07690	COG0651	ATP synthesis coupled electron transport
HQ398_RS07695	COG0650	Formate hydrogenlyase subunit 4
HQ398_RS07700	COG3261	NADH dehydrogenase
HQ398_RS07700	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HQ398_RS07705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_RS07710	COG3260	NADH ubiquinone oxidoreductase 20
HQ398_RS07720	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HQ398_RS07730	COG1921	L-seryl-tRNASec selenium transferase activity
HQ398_RS07740	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HQ398_RS07745	COG0298	carbon dioxide binding
HQ398_RS07760	COG0375	protein maturation
HQ398_RS07765	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HQ398_RS07770	COG3842	ATPase activity
HQ398_RS07780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HQ398_RS07795	COG1773	rubredoxin
HQ398_RS07800	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HQ398_RS07805	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HQ398_RS07810	COG5557	Pfam Polysulphide reductase, NrfD
HQ398_RS07815	COG0437	4 iron, 4 sulfur cluster binding
HQ398_RS07820	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HQ398_RS07855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HQ398_RS07870	COG2003	Belongs to the UPF0758 family
HQ398_RS07905	COG3385	transposase activity
HQ398_RS07915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HQ398_RS07935	COG0730	response to heat
HQ398_RS07955	COG1024	Enoyl-CoA hydratase
HQ398_RS07960	COG1024	Enoyl-CoA hydratase
HQ398_RS07965	COG1960	acyl-CoA dehydrogenase activity
HQ398_RS07970	COG1960	acyl-CoA dehydrogenase activity
HQ398_RS07975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HQ398_RS07980	COG1024	Enoyl-CoA hydratase
HQ398_RS08010	COG1584	GPR1 FUN34 yaaH family protein
HQ398_RS08015	COG3228	Belongs to the MtfA family
HQ398_RS08025	COG1115	amino acid carrier protein
HQ398_RS08030	COG1024	Enoyl-CoA hydratase
HQ398_RS08045	COG3162	membrane
HQ398_RS08050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQ398_RS08055	COG0488	(ABC) transporter
HQ398_RS08060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ398_RS08065	COG0776	regulation of translation
HQ398_RS08070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HQ398_RS08075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HQ398_RS08080	COG0740	serine-type endopeptidase activity
HQ398_RS08085	COG0544	peptidyl-prolyl cis-trans isomerase activity
HQ398_RS08095	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HQ398_RS08100	COG4591	ABC-type transport system involved in lipoprotein release permease component
HQ398_RS08105	COG1136	(ABC) transporter
HQ398_RS08110	COG4591	ABC-type transport system involved in lipoprotein release permease component
HQ398_RS08120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HQ398_RS08125	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HQ398_RS08130	COG4166	transmembrane transport
HQ398_RS08135	COG0697	spore germination
HQ398_RS08145	COG2062	phosphohistidine phosphatase, SixA
HQ398_RS08175	COG3385	transposase activity
HQ398_RS08185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HQ398_RS08185	COG0519	Catalyzes the synthesis of GMP from XMP
HQ398_RS08190	COG0516	GMP reductase activity
HQ398_RS08190	COG0517	IMP dehydrogenase activity
HQ398_RS08200	COG3158	transport of potassium into the cell
HQ398_RS08220	COG1570	exodeoxyribonuclease VII activity
HQ398_RS08225	COG2188	Transcriptional regulator
HQ398_RS08230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_RS08230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_RS08230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS08235	COG0383	alpha-mannosidase activity
HQ398_RS08240	COG1181	Belongs to the D-alanine--D-alanine ligase family
HQ398_RS08250	COG0386	Belongs to the glutathione peroxidase family
HQ398_RS08255	COG0513	Belongs to the DEAD box helicase family
HQ398_RS08270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ398_RS08275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HQ398_RS08345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ398_RS08355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HQ398_RS08360	COG0563	adenylate kinase activity
HQ398_RS08370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HQ398_RS08375	COG1286	toxin biosynthetic process
HQ398_RS08380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HQ398_RS08390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HQ398_RS08395	COG0531	amino acid
HQ398_RS08395	COG1674	ftsk spoiiie
HQ398_RS08410	COG0492	ferredoxin-NADP+ reductase activity
HQ398_RS08415	COG3706	GGDEF domain
HQ398_RS08420	COG3134	Outer membrane lipoprotein
HQ398_RS08425	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HQ398_RS08430	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HQ398_RS08435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HQ398_RS08440	COG0542	response to heat
HQ398_RS08445	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HQ398_RS08450	COG1278	Cold shock
HQ398_RS08455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HQ398_RS08475	COG0745	RESPONSE REGULATOR receiver
HQ398_RS08480	COG2205	protein histidine kinase activity
HQ398_RS08490	COG0392	lysyltransferase activity
HQ398_RS08490	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HQ398_RS08500	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HQ398_RS08530	COG1435	thymidine kinase activity
HQ398_RS08535	COG1757	Na H antiporter
HQ398_RS08540	COG2916	Histone family protein nucleoid-structuring protein H-NS
HQ398_RS08545	COG2096	Adenosyltransferase
HQ398_RS08550	COG3530	Putative quorum-sensing-regulated virulence factor
HQ398_RS08555	COG0602	queuosine metabolic process
HQ398_RS08560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HQ398_RS08580	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HQ398_RS08590	COG0776	regulation of translation
HQ398_RS08595	COG0539	negative regulation of cytoplasmic translation
HQ398_RS08600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HQ398_RS08605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQ398_RS08620	COG2814	Major facilitator Superfamily
HQ398_RS08640	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HQ398_RS08645	COG5001	Diguanylate cyclase
HQ398_RS08645	COG3300	MHYT domain
HQ398_RS08650	COG0583	DNA-binding transcription factor activity
HQ398_RS08655	COG3437	response regulator, receiver
HQ398_RS08680	COG4989	oxidoreductase activity
HQ398_RS08685	COG0724	RNA recognition motif
HQ398_RS08695	COG1126	abc transporter atp-binding protein
HQ398_RS08700	COG0765	amino acid transport
HQ398_RS08705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_RS08710	COG4597	amino acid ABC transporter
HQ398_RS08715	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HQ398_RS08725	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HQ398_RS08740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ398_RS08745	COG1360	Flagellar Motor Protein
HQ398_RS08750	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_RS08755	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_RS08760	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_RS08760	COG0649	NAD binding
HQ398_RS08775	COG1034	ATP synthesis coupled electron transport
HQ398_RS08780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HQ398_RS08785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_RS08790	COG0839	Belongs to the complex I subunit 6 family
HQ398_RS08795	COG0713	ATP synthesis coupled electron transport
HQ398_RS08805	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_RS08810	COG1007	ATP synthesis coupled electron transport
HQ398_RS08815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HQ398_RS08815	COG0047	phosphoribosylformylglycinamidine synthase activity
HQ398_RS08820	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HQ398_RS08825	COG1645	bacterial-type flagellum-dependent swarming motility
HQ398_RS08830	COG1160	GTP binding
HQ398_RS08835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ398_RS08840	COG2976	Protein conserved in bacteria
HQ398_RS08845	COG0124	histidyl-tRNA synthetase
HQ398_RS08865	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HQ398_RS08870	COG0105	UTP biosynthetic process
HQ398_RS08875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ398_RS08885	COG0633	Ferredoxin
HQ398_RS08890	COG0443	Heat shock 70 kDa protein
HQ398_RS08895	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HQ398_RS08905	COG0822	iron-sulfur transferase activity
HQ398_RS08910	COG1104	cysteine desulfurase activity
HQ398_RS08915	COG1959	2 iron, 2 sulfur cluster binding
HQ398_RS08930	COG3154	lipid carrier protein
HQ398_RS08935	COG0826	peptidase U32
HQ398_RS08940	COG0826	peptidase U32
HQ398_RS08955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ398_RS08960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ398_RS08965	COG1862	Preprotein translocase
HQ398_RS08970	COG0343	queuine tRNA-ribosyltransferase activity
HQ398_RS08975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HQ398_RS08980	COG1125	glycine betaine transport
HQ398_RS08980	COG0517	IMP dehydrogenase activity
HQ398_RS08990	COG3634	alkyl hydroperoxide reductase activity
HQ398_RS09035	COG1242	4 iron, 4 sulfur cluster binding
HQ398_RS09045	COG0493	'glutamate synthase
HQ398_RS09050	COG1126	abc transporter atp-binding protein
HQ398_RS09055	COG0765	amino acid transport
HQ398_RS09060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_RS09075	COG0513	Belongs to the DEAD box helicase family
HQ398_RS09090	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HQ398_RS09105	COG2119	membrane
HQ398_RS09155	COG0215	cysteine-tRNA ligase activity
HQ398_RS09160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQ398_RS09170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ398_RS09180	COG2261	transglycosylase associated protein
HQ398_RS09185	COG0642	Histidine kinase
HQ398_RS09225	COG3501	Rhs element vgr protein
HQ398_RS09280	COG1454	alcohol dehydrogenase
HQ398_RS09280	COG1012	belongs to the aldehyde dehydrogenase family
HQ398_RS09295	COG1882	Formate acetyltransferase
HQ398_RS09300	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ398_RS09310	COG4869	propanediol catabolic process
HQ398_RS09355	COG0322	excinuclease ABC activity
HQ398_RS09360	COG2197	response regulator
HQ398_RS09365	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HQ398_RS09370	COG2835	tetraacyldisaccharide 4'-kinase activity
HQ398_RS09375	COG1663	tetraacyldisaccharide 4'-kinase activity
HQ398_RS09400	COG1448	Aminotransferase
HQ398_RS09410	COG0583	DNA-binding transcription factor activity
HQ398_RS09415	COG3085	chromosome segregation
HQ398_RS09420	COG4574	serine-type endopeptidase inhibitor activity
HQ398_RS09425	COG0584	glycerophosphoryl diester phosphodiesterase
HQ398_RS09435	COG1349	DNA-binding transcription factor activity
HQ398_RS09440	COG2271	Major facilitator Superfamily
HQ398_RS09445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HQ398_RS09450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HQ398_RS09455	COG0840	transmembrane signaling receptor activity
HQ398_RS09465	COG0583	DNA-binding transcription factor activity
HQ398_RS09490	COG0656	L-ascorbic acid biosynthetic process
HQ398_RS09495	COG2814	Major facilitator Superfamily
HQ398_RS09500	COG2249	NAD(P)H dehydrogenase (quinone) activity
HQ398_RS09515	COG3220	belongs to the UPF0276 family
HQ398_RS09535	COG1294	oxidase, subunit
HQ398_RS09545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HQ398_RS09575	COG2807	transmembrane transport
HQ398_RS09580	COG1187	pseudouridine synthase activity
HQ398_RS09585	COG0346	lactoylglutathione lyase activity
HQ398_RS09595	COG1403	HNH endonuclease
HQ398_RS09600	COG4657	Part of a membrane complex involved in electron transport
HQ398_RS09605	COG2878	Part of a membrane complex involved in electron transport
HQ398_RS09615	COG4658	electron transport chain
HQ398_RS09620	COG4659	FMN binding
HQ398_RS09625	COG4660	Part of a membrane complex involved in electron transport
HQ398_RS09630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HQ398_RS09635	COG0346	lactoylglutathione lyase activity
HQ398_RS09650	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HQ398_RS09670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HQ398_RS09675	COG0505	Belongs to the CarA family
HQ398_RS09680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HQ398_RS09690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HQ398_RS09695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HQ398_RS09700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HQ398_RS09705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HQ398_RS09710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HQ398_RS09715	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HQ398_RS09740	COG2020	methyltransferase activity
HQ398_RS09745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQ398_RS09750	COG0861	Integral membrane protein TerC family
HQ398_RS09780	COG2095	MarC family integral membrane protein
HQ398_RS09785	COG1012	belongs to the aldehyde dehydrogenase family
HQ398_RS09785	COG1454	alcohol dehydrogenase
HQ398_RS09795	COG3385	transposase activity
HQ398_RS09800	COG2194	sulfuric ester hydrolase activity
HQ398_RS09805	COG0217	transcriptional regulatory protein
HQ398_RS09810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HQ398_RS09820	COG1801	Protein of unknown function DUF72
HQ398_RS09825	COG4106	trans-aconitate 2-methyltransferase activity
HQ398_RS09830	COG0500	methyltransferase
HQ398_RS09850	COG0450	alkyl hydroperoxide reductase
HQ398_RS09855	COG0583	DNA-binding transcription factor activity
HQ398_RS09860	COG0791	NLP P60 protein
HQ398_RS09870	COG0583	DNA-binding transcription factor activity
HQ398_RS09875	COG2610	gluconate transmembrane transporter activity
HQ398_RS09880	COG3048	D-serine ammonia-lyase activity
HQ398_RS09885	COG0538	isocitrate dehydrogenase activity
HQ398_RS09890	COG2207	Transcriptional regulator
HQ398_RS09915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_RS09930	COG4521	taurine ABC transporter
HQ398_RS09935	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HQ398_RS09945	COG2175	clavaminate synthase activity
HQ398_RS09950	COG3152	Membrane
HQ398_RS09955	COG2814	Major facilitator Superfamily
HQ398_RS09960	COG0109	protoheme IX farnesyltransferase activity
HQ398_RS09965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HQ398_RS09970	COG1845	cytochrome c oxidase, subunit III
HQ398_RS09980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HQ398_RS10015	COG1309	transcriptional regulator
HQ398_RS10025	COG1454	alcohol dehydrogenase
HQ398_RS10045	COG0534	Mate efflux family protein
HQ398_RS10060	COG2841	Protein conserved in bacteria
HQ398_RS10065	COG3132	Protein of unknown function, DUF480
HQ398_RS10095	COG0708	Exodeoxyribonuclease III
HQ398_RS10115	COG1122	ATPase activity
HQ398_RS10120	COG1122	ATPase activity
HQ398_RS10140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_RS10145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQ398_RS10155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HQ398_RS10160	COG1120	ATPase activity
HQ398_RS10165	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ398_RS10170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ398_RS10175	COG2375	cellular response to nickel ion
HQ398_RS10180	COG0784	Response regulator, receiver
HQ398_RS10180	COG3437	response regulator, receiver
HQ398_RS10190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HQ398_RS10195	COG0328	RNA-DNA hybrid ribonuclease activity
HQ398_RS10200	COG2226	methyltransferase
HQ398_RS10205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ398_RS10210	COG0741	lytic transglycosylase activity
HQ398_RS10210	COG1388	LysM domain
HQ398_RS10240	COG1376	ErfK ybiS ycfS ynhG family protein
HQ398_RS10240	COG1388	LysM domain
HQ398_RS10250	COG0471	metal ion transport
HQ398_RS10260	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HQ398_RS10265	COG0791	NLP P60 protein
HQ398_RS10275	COG3118	belongs to the thioredoxin family
HQ398_RS10285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQ398_RS10290	COG0788	formyltetrahydrofolate deformylase activity
HQ398_RS10315	COG0741	lytic transglycosylase activity
HQ398_RS10315	COG0739	heme binding
HQ398_RS10315	COG1196	nuclear chromosome segregation
HQ398_RS10320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HQ398_RS10330	COG0436	Aminotransferase
HQ398_RS10335	COG1288	antiporter activity
HQ398_RS10340	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HQ398_RS10345	COG1879	ABC-type sugar transport system periplasmic component
HQ398_RS10355	COG0406	alpha-ribazole phosphatase activity
HQ398_RS10360	COG2964	Protein conserved in bacteria
HQ398_RS10365	COG3681	Belongs to the UPF0597 family
HQ398_RS10375	COG0814	amino acid
HQ398_RS10380	COG0840	transmembrane signaling receptor activity
HQ398_RS10395	COG1166	arginine decarboxylase activity
HQ398_RS10400	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ398_RS10430	COG0583	DNA-binding transcription factor activity
HQ398_RS10445	COG0840	transmembrane signaling receptor activity
HQ398_RS10450	COG0302	gtp cyclohydrolase
HQ398_RS10455	COG0303	'Molybdopterin
HQ398_RS10460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HQ398_RS10480	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HQ398_RS10495	COG0314	molybdopterin synthase activity
HQ398_RS10500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HQ398_RS10505	COG0315	cyclic pyranopterin monophosphate synthase activity
HQ398_RS10515	COG3005	denitrification pathway
HQ398_RS10525	COG0348	domain, Protein
HQ398_RS10530	COG0437	4 iron, 4 sulfur cluster binding
HQ398_RS10535	COG0243	molybdopterin cofactor binding
HQ398_RS10545	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_RS10545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_RS10550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HQ398_RS10555	COG3850	Histidine kinase
HQ398_RS10560	COG2197	response regulator
HQ398_RS10590	COG0121	glutamine amidotransferase
HQ398_RS10595	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HQ398_RS10600	COG1960	acyl-CoA dehydrogenase activity
HQ398_RS10605	COG1473	amidohydrolase
HQ398_RS10610	COG2914	Belongs to the UPF0125 (RnfH) family
HQ398_RS10615	COG2867	negative regulation of translational initiation
HQ398_RS10620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HQ398_RS10630	COG0582	viral genome integration into host DNA
HQ398_RS10645	COG3311	Transcriptional regulator
HQ398_RS10655	COG5377	YqaJ viral recombinase family
HQ398_RS10700	COG2003	Belongs to the UPF0758 family
HQ398_RS10720	COG3385	transposase activity
HQ398_RS10795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ398_RS10835	COG1715	Restriction endonuclease
HQ398_RS10845	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HQ398_RS10900	COG0477	Major facilitator Superfamily
HQ398_RS10900	COG2814	Major facilitator Superfamily
HQ398_RS10905	COG0457	Tetratricopeptide repeat
HQ398_RS10910	COG1940	carbohydrate kinase activity
HQ398_RS10915	COG3383	formate dehydrogenase (NAD+) activity
HQ398_RS10925	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HQ398_RS10935	COG1960	acyl-CoA dehydrogenase activity
HQ398_RS10940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HQ398_RS10960	COG1317	bacterial-type flagellum organization
HQ398_RS11015	COG3385	transposase activity
HQ398_RS11055	COG0457	Tetratricopeptide repeat
HQ398_RS11125	COG4790	Type iii secretion
HQ398_RS11130	COG4794	Type iii secretion
HQ398_RS11135	COG4791	protein targeting
HQ398_RS11140	COG4792	protein secretion
HQ398_RS11155	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HQ398_RS11160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_RS11160	COG1263	PTS System
HQ398_RS11165	COG1609	Transcriptional regulator
HQ398_RS11175	COG4821	SIS domain
HQ398_RS11185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_RS11185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS11185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_RS11195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HQ398_RS11205	COG1187	pseudouridine synthase activity
HQ398_RS11210	COG1051	belongs to the nudix hydrolase family
HQ398_RS11215	COG0482	sulfurtransferase activity
HQ398_RS11220	COG2915	High frequency lysogenization protein hflD homolog
HQ398_RS11225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HQ398_RS11230	COG2850	peptidyl-arginine hydroxylation
HQ398_RS11240	COG1397	ADP-ribosylglycohydrolase
HQ398_RS11250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ398_RS11270	COG0625	glutathione transferase activity
HQ398_RS11275	COG0259	pyridoxamine-phosphate oxidase activity
HQ398_RS11280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ398_RS11280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ398_RS11290	COG1882	Formate acetyltransferase
HQ398_RS11295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HQ398_RS11310	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HQ398_RS11325	COG4235	cytochrome complex assembly
HQ398_RS11325	COG3088	subunit of a heme lyase
HQ398_RS11335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ398_RS11340	COG1138	Cytochrome C-type biogenesis protein
HQ398_RS11345	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HQ398_RS11350	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQ398_RS11355	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQ398_RS11360	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQ398_RS11375	COG0835	chemotaxis
HQ398_RS11385	COG1192	Involved in chromosome partitioning
HQ398_RS11390	COG1360	Flagellar Motor Protein
HQ398_RS11395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ398_RS11400	COG2201	protein-glutamate methylesterase activity
HQ398_RS11405	COG2198	Histidine kinase
HQ398_RS11405	COG0784	Response regulator, receiver
HQ398_RS11405	COG0643	Histidine kinase
HQ398_RS11410	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HQ398_RS11435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HQ398_RS11500	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HQ398_RS11510	COG1677	Flagellar hook-basal body complex protein FliE
HQ398_RS11520	COG0469	pyruvate kinase activity
HQ398_RS11525	COG1737	Transcriptional regulator
HQ398_RS11560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_RS11565	COG2233	PERMEase
HQ398_RS11570	COG0281	malic enzyme
HQ398_RS11575	COG0745	RESPONSE REGULATOR receiver
HQ398_RS11585	COG0437	4 iron, 4 sulfur cluster binding
HQ398_RS11590	COG3383	formate dehydrogenase (NAD+) activity
HQ398_RS11590	COG3383	formate dehydrogenase (NAD+) activity
HQ398_RS11630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HQ398_RS11640	COG3852	Histidine kinase
HQ398_RS11645	COG2204	response regulator
HQ398_RS11655	COG4662	Binding-protein-dependent transport system inner membrane component
HQ398_RS11660	COG1136	(ABC) transporter
HQ398_RS11670	COG0303	'Molybdopterin
HQ398_RS11675	COG1289	transmembrane transporter activity
HQ398_RS11680	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HQ398_RS11720	COG0784	Response regulator, receiver
HQ398_RS11720	COG2205	protein histidine kinase activity
HQ398_RS11725	COG4166	transmembrane transport
HQ398_RS11730	COG0601	transmembrane transport
HQ398_RS11735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HQ398_RS11740	COG0444	Belongs to the ABC transporter superfamily
HQ398_RS11745	COG4608	Belongs to the ABC transporter superfamily
HQ398_RS11780	COG3724	N-succinylarginine dihydrolase activity
HQ398_RS11805	COG0784	Response regulator, receiver
HQ398_RS11805	COG2205	protein histidine kinase activity
HQ398_RS11805	COG5002	protein histidine kinase activity
HQ398_RS11810	COG2197	response regulator
HQ398_RS11835	COG2203	Gaf domain
HQ398_RS11835	COG2199	diguanylate cyclase activity
HQ398_RS11835	COG2200	EAL domain
HQ398_RS11840	COG0826	peptidase U32
HQ398_RS11845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ398_RS11855	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HQ398_RS11860	COG2199	diguanylate cyclase activity
HQ398_RS11860	COG2203	Gaf domain
HQ398_RS11865	COG2211	Major facilitator Superfamily
HQ398_RS11870	COG0616	signal peptide processing
HQ398_RS11875	COG1028	Short-chain dehydrogenase reductase Sdr
HQ398_RS11880	COG0583	DNA-binding transcription factor activity
HQ398_RS11890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HQ398_RS11905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HQ398_RS11910	COG1881	PFAM PEBP family protein
HQ398_RS11930	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HQ398_RS11945	COG1301	dicarboxylic acid transport
HQ398_RS11950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HQ398_RS11955	COG2912	Transglutaminase-like superfamily
HQ398_RS11970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HQ398_RS11975	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HQ398_RS11980	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HQ398_RS11985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HQ398_RS11995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HQ398_RS12000	COG0737	Belongs to the 5'-nucleotidase family
HQ398_RS12005	COG0193	aminoacyl-tRNA hydrolase activity
HQ398_RS12010	COG0012	GTP binding
HQ398_RS12015	COG1012	belongs to the aldehyde dehydrogenase family
HQ398_RS12020	COG1177	transmembrane transport
HQ398_RS12025	COG1176	ABC-type spermidine putrescine transport system, permease component I
HQ398_RS12030	COG3842	ATPase activity
HQ398_RS12035	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HQ398_RS12040	COG0583	DNA-binding transcription factor activity
HQ398_RS12085	COG0471	metal ion transport
HQ398_RS12085	COG0490	domain, Protein
HQ398_RS12105	COG3097	Belongs to the UPF0267 family
HQ398_RS12115	COG0366	Alpha amylase catalytic
HQ398_RS12120	COG0674	pyruvate-flavodoxin oxidoreductase activity
HQ398_RS12120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ398_RS12120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HQ398_RS12120	COG1013	pyruvate-flavodoxin oxidoreductase activity
HQ398_RS12130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ398_RS12145	COG1012	belongs to the aldehyde dehydrogenase family
HQ398_RS12160	COG0512	Glutamine amidotransferase of anthranilate synthase
HQ398_RS12170	COG0180	Tryptophanyl-tRNA synthetase
HQ398_RS12180	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HQ398_RS12185	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HQ398_RS12195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HQ398_RS12200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HQ398_RS12230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HQ398_RS12235	COG0583	DNA-binding transcription factor activity
HQ398_RS12265	COG0739	heme binding
HQ398_RS12275	COG1511	domain protein
HQ398_RS12275	COG3264	Mechanosensitive ion channel
HQ398_RS12280	COG0584	glycerophosphoryl diester phosphodiesterase
HQ398_RS12290	COG1053	succinate dehydrogenase
HQ398_RS12295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HQ398_RS12300	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HQ398_RS12310	COG3366	ferrous iron transmembrane transporter activity
HQ398_RS12315	COG0700	Nucleoside recognition
HQ398_RS12320	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ398_RS12330	COG3214	Protein conserved in bacteria
HQ398_RS12345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ398_RS12360	COG0318	PFAM AMP-dependent synthetase and ligase
HQ398_RS12370	COG1028	Short-chain dehydrogenase reductase Sdr
HQ398_RS12395	COG0516	GMP reductase activity
HQ398_RS12405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HQ398_RS12415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ398_RS12425	COG0583	DNA-binding transcription factor activity
HQ398_RS12430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HQ398_RS12440	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ398_RS12465	COG3706	GGDEF domain
HQ398_RS12470	COG1335	isochorismatase
HQ398_RS12480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQ398_RS12485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQ398_RS12490	COG1702	phosphate starvation-inducible protein PhoH
HQ398_RS12495	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HQ398_RS12500	COG4535	Mg2 and Co2 transporter CorC
HQ398_RS12510	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HQ398_RS12530	COG1970	mechanosensitive ion channel activity
HQ398_RS12535	COG4974	Belongs to the 'phage' integrase family
HQ398_RS12540	COG0716	FMN binding
HQ398_RS12550	COG0312	modulator of DNA gyrase
HQ398_RS12560	COG2888	peptidyl-tyrosine sulfation
HQ398_RS12565	COG0495	leucyl-tRNA aminoacylation
HQ398_RS12580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HQ398_RS12585	COG0799	negative regulation of ribosome biogenesis
HQ398_RS12595	COG0768	penicillin binding
HQ398_RS12600	COG0772	Belongs to the SEDS family
HQ398_RS12605	COG2951	lytic endotransglycosylase activity
HQ398_RS12615	COG1686	Belongs to the peptidase S11 family
HQ398_RS12620	COG2921	Belongs to the UPF0250 family
HQ398_RS12625	COG0321	lipoyl(octanoyl) transferase activity
HQ398_RS12630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HQ398_RS12650	COG3139	Protein of unknown function (DUF1315)
HQ398_RS12655	COG0252	asparaginase activity
HQ398_RS12660	COG0786	glutamate:sodium symporter activity
HQ398_RS12675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HQ398_RS12685	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQ398_RS12690	COG0175	sulfate reduction
HQ398_RS12705	COG2966	Psort location CytoplasmicMembrane, score
HQ398_RS12715	COG0521	Mo-molybdopterin cofactor biosynthetic process
HQ398_RS12730	COG2897	thiosulfate sulfurtransferase activity
HQ398_RS12735	COG2066	Belongs to the glutaminase family
HQ398_RS12740	COG3171	Protein conserved in bacteria
HQ398_RS12745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HQ398_RS12750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HQ398_RS12755	COG2200	EAL domain
HQ398_RS12770	COG4181	ATPase activity
HQ398_RS12775	COG2755	lipolytic protein G-D-S-L family
HQ398_RS12780	COG0784	Response regulator, receiver
HQ398_RS12780	COG0835	chemotaxis
HQ398_RS12820	COG3397	chitin binding
HQ398_RS12845	COG3655	Transcriptional regulator
HQ398_RS12855	COG2814	Major facilitator Superfamily
HQ398_RS12860	COG3385	transposase activity
HQ398_RS12895	COG2771	luxR family
HQ398_RS12920	COG0748	coenzyme F420 binding
HQ398_RS12925	COG3721	Heme iron utilization protein
HQ398_RS12935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQ398_RS12950	COG3275	phosphorelay sensor kinase activity
HQ398_RS12955	COG3279	Response regulator of the LytR AlgR family
HQ398_RS12960	COG1966	Carbon starvation protein
HQ398_RS12975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQ398_RS12990	COG0737	Belongs to the 5'-nucleotidase family
HQ398_RS13015	COG0545	Peptidyl-prolyl cis-trans isomerase
HQ398_RS13030	COG1047	Peptidyl-prolyl cis-trans
HQ398_RS13035	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HQ398_RS13045	COG0784	Response regulator, receiver
HQ398_RS13045	COG0835	chemotaxis
HQ398_RS13055	COG2203	Gaf domain
HQ398_RS13055	COG4251	negative regulation of phosphorylation
HQ398_RS13055	COG5001	Diguanylate cyclase
HQ398_RS13055	COG3706	GGDEF domain
HQ398_RS13060	COG3089	Belongs to the UPF0270 family
HQ398_RS13065	COG3954	Phosphoribulokinase
HQ398_RS13080	COG1765	OsmC-like protein
HQ398_RS13130	COG2313	pseudouridylate synthase activity
HQ398_RS13165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ398_RS13180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ398_RS13190	COG2986	histidine ammonia-lyase
HQ398_RS13215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ398_RS13220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ398_RS13225	COG1028	Short-chain dehydrogenase reductase Sdr
HQ398_RS13230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ398_RS13250	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HQ398_RS13325	COG0569	domain protein
HQ398_RS13325	COG2985	domain, Protein
HQ398_RS13335	COG0076	glutamate decarboxylase activity
HQ398_RS13340	COG2917	probably involved in intracellular septation
HQ398_RS13345	COG2350	Protein conserved in bacteria
HQ398_RS13365	COG2222	sugar isomerase
HQ398_RS13370	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_RS13380	COG3716	PTS system mannose fructose sorbose family IID component
HQ398_RS13385	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS13390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ398_RS13400	COG1263	PTS System
HQ398_RS13400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_RS13405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HQ398_RS13410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HQ398_RS13415	COG1381	Involved in DNA repair and RecF pathway recombination
HQ398_RS13430	COG0681	Belongs to the peptidase S26 family
HQ398_RS13435	COG0481	GTPase activity
HQ398_RS13445	COG3026	antisigma factor binding
HQ398_RS13450	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HQ398_RS13455	COG1595	DNA-templated transcription, initiation
HQ398_RS13460	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HQ398_RS13475	COG0354	folic acid binding
HQ398_RS13520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ398_RS13530	COG0126	phosphoglycerate kinase activity
HQ398_RS13535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQ398_RS13540	COG1940	carbohydrate kinase activity
HQ398_RS13545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HQ398_RS13550	COG2816	NAD+ diphosphatase activity
HQ398_RS13560	COG4991	sh3 domain protein
HQ398_RS13565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQ398_RS13575	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HQ398_RS13610	COG2816	NAD+ diphosphatase activity
HQ398_RS13650	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HQ398_RS13660	COG2203	Gaf domain
HQ398_RS13660	COG2199	diguanylate cyclase activity
HQ398_RS13665	COG0513	Belongs to the DEAD box helicase family
HQ398_RS13670	COG0471	metal ion transport
HQ398_RS13680	COG3385	transposase activity
HQ398_RS13690	COG0154	amidase activity
HQ398_RS13695	COG2957	Belongs to the agmatine deiminase family
HQ398_RS13710	COG1902	pentaerythritol trinitrate reductase activity
HQ398_RS13720	COG1388	LysM domain
HQ398_RS13720	COG4942	peptidase
HQ398_RS13725	COG1238	metal cluster binding
HQ398_RS13730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HQ398_RS13735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HQ398_RS13740	COG0585	pseudouridine synthase activity
HQ398_RS13755	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HQ398_RS13760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQ398_RS13770	COG1376	ErfK ybiS ycfS ynhG family protein
HQ398_RS13775	COG0668	transmembrane transport
HQ398_RS13785	COG2731	YhcH YjgK YiaL family protein
HQ398_RS13795	COG1794	racemase activity, acting on amino acids and derivatives
HQ398_RS13825	COG0517	IMP dehydrogenase activity
HQ398_RS13825	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HQ398_RS13830	COG0488	(ABC) transporter
HQ398_RS13840	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HQ398_RS13850	COG3385	transposase activity
HQ398_RS13855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HQ398_RS13865	COG0148	phosphopyruvate hydratase activity
HQ398_RS13870	COG0504	CTP synthase activity
HQ398_RS13875	COG3956	TIGRFAM MazG family protein
HQ398_RS13880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HQ398_RS13895	COG4807	Protein conserved in bacteria
HQ398_RS13900	COG3023	N-Acetylmuramoyl-L-alanine amidase
HQ398_RS13905	COG0783	Belongs to the Dps family
HQ398_RS13910	COG1151	hydroxylamine reductase activity
HQ398_RS13915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ398_RS13920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HQ398_RS13925	COG0671	phosphoesterase, PA-phosphatase related
HQ398_RS13930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQ398_RS13935	COG0163	prenyltransferase activity
HQ398_RS13950	COG1131	(ABC) transporter
HQ398_RS13955	COG0842	Transport permease protein
HQ398_RS13960	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HQ398_RS13965	COG1924	4 iron, 4 sulfur cluster binding
HQ398_RS13985	COG1823	symporter activity
HQ398_RS13995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HQ398_RS14000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HQ398_RS14005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HQ398_RS14015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ398_RS14020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HQ398_RS14025	COG1489	DNA binding
HQ398_RS14035	COG1643	Atp-dependent helicase
HQ398_RS14040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HQ398_RS14045	COG0346	lactoylglutathione lyase activity
HQ398_RS14050	COG2076	Multidrug Resistance protein
HQ398_RS14055	COG2076	Multidrug Resistance protein
HQ398_RS14065	COG3437	response regulator, receiver
HQ398_RS14065	COG0784	Response regulator, receiver
HQ398_RS14070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HQ398_RS14085	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HQ398_RS14100	COG1136	(ABC) transporter
HQ398_RS14120	COG0840	transmembrane signaling receptor activity
HQ398_RS14135	COG0529	Catalyzes the synthesis of activated sulfate
HQ398_RS14140	COG2895	sulfate adenylyltransferase (ATP) activity
HQ398_RS14145	COG0175	sulfate reduction
HQ398_RS14150	COG1648	precorrin-2 dehydrogenase activity
HQ398_RS14150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQ398_RS14155	COG0330	HflC and HflK could
HQ398_RS14160	COG1585	Membrane protein implicated in regulation of membrane protease activity
HQ398_RS14165	COG0840	transmembrane signaling receptor activity
HQ398_RS14170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HQ398_RS14180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQ398_RS14185	COG1640	4-alpha-glucanotransferase
HQ398_RS14190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HQ398_RS14210	COG1051	belongs to the nudix hydrolase family
HQ398_RS14235	COG0561	phosphatase activity
HQ398_RS14250	COG0733	neurotransmitter:sodium symporter activity
HQ398_RS14260	COG0733	neurotransmitter:sodium symporter activity
HQ398_RS14325	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HQ398_RS14330	COG2885	chlorophyll binding
HQ398_RS14335	COG0823	Involved in the tonB-independent uptake of proteins
HQ398_RS14350	COG0811	peptide transport
HQ398_RS14355	COG0824	Thioesterase
HQ398_RS14360	COG3790	cyd operon protein YbgE
HQ398_RS14365	COG4890	Cyd operon protein YbgT
HQ398_RS14370	COG1294	oxidase, subunit
HQ398_RS14375	COG1271	oxidase subunit
HQ398_RS14380	COG2255	four-way junction helicase activity
HQ398_RS14385	COG0632	four-way junction helicase activity
HQ398_RS14390	COG0840	transmembrane signaling receptor activity
HQ398_RS14400	COG2771	luxR family
HQ398_RS14415	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HQ398_RS14420	COG4251	negative regulation of phosphorylation
HQ398_RS14420	COG2203	Gaf domain
HQ398_RS14420	COG3706	GGDEF domain
HQ398_RS14420	COG5001	Diguanylate cyclase
HQ398_RS14430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ398_RS14440	COG2995	paraquat-inducible protein a
HQ398_RS14445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HQ398_RS14445	COG3008	intermembrane lipid transfer
HQ398_RS14450	COG3009	Protein conserved in bacteria
HQ398_RS14455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQ398_RS14460	COG0442	prolyl-tRNA aminoacylation
HQ398_RS14485	COG4221	oxidoreductase activity
HQ398_RS14500	COG1024	Enoyl-CoA hydratase
HQ398_RS14510	COG0110	maltose O-acetyltransferase activity
HQ398_RS14520	COG4166	transmembrane transport
HQ398_RS14530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HQ398_RS14535	COG0735	belongs to the Fur family
HQ398_RS14565	COG0513	Belongs to the DEAD box helicase family
HQ398_RS14570	COG2153	protein acetylation
HQ398_RS14585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQ398_RS14590	COG0557	exoribonuclease II activity
HQ398_RS14595	COG3706	GGDEF domain
HQ398_RS14605	COG3240	lipase activity
HQ398_RS14620	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HQ398_RS14625	COG1194	a g-specific adenine glycosylase
HQ398_RS14630	COG0617	tRNA 3'-terminal CCA addition
HQ398_RS14650	COG3068	Protein conserved in bacteria
HQ398_RS14660	COG0739	heme binding
HQ398_RS14680	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HQ398_RS14685	COG1121	(ABC) transporter
HQ398_RS14690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HQ398_RS14695	COG0583	DNA-binding transcription factor activity
HQ398_RS14700	COG0697	spore germination
HQ398_RS14705	COG1573	uracil-dna glycosylase
HQ398_RS14720	COG2827	Endonuclease containing a URI domain
HQ398_RS14735	COG1842	Phage shock protein A
HQ398_RS14740	COG0204	Acyl-transferase
HQ398_RS14760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ398_RS14765	COG0583	DNA-binding transcription factor activity
HQ398_RS14770	COG2084	Dehydrogenase
HQ398_RS14800	COG3104	oligopeptide transport
HQ398_RS14810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HQ398_RS14825	COG0187	DNA topoisomerase II activity
HQ398_RS14830	COG1289	transmembrane transporter activity
HQ398_RS14835	COG1566	PFAM secretion protein HlyD family protein
HQ398_RS14845	COG1051	belongs to the nudix hydrolase family
HQ398_RS14850	COG3150	esterase
HQ398_RS14860	COG3151	Protein conserved in bacteria
HQ398_RS14865	COG0494	nUDIX hydrolase
HQ398_RS14870	COG1538	Outer membrane efflux protein
HQ398_RS14875	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HQ398_RS14875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HQ398_RS14880	COG1560	Kdo2-lipid A biosynthetic process
HQ398_RS14885	COG2213	PTS system mannitol-specific
HQ398_RS14885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS14890	COG0246	Mannitol dehydrogenase
HQ398_RS14895	COG3722	fumarate hydratase activity
HQ398_RS14920	COG1671	Belongs to the UPF0178 family
HQ398_RS14935	COG1988	membrane-bound metal-dependent
HQ398_RS14940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ398_RS14945	COG0513	Belongs to the DEAD box helicase family
HQ398_RS14965	COG1575	Belongs to the MenA family. Type 1 subfamily
HQ398_RS14970	COG1169	isochorismate synthase
HQ398_RS14985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HQ398_RS14995	COG0318	PFAM AMP-dependent synthetase and ligase
HQ398_RS15000	COG3291	Pkd domain containing protein
HQ398_RS15010	COG0835	chemotaxis
HQ398_RS15010	COG0784	Response regulator, receiver
HQ398_RS15020	COG1444	tRNA N-acetyltransferase activity
HQ398_RS15040	COG1803	Methylglyoxal synthase
HQ398_RS15045	COG1979	alcohol dehydrogenase
HQ398_RS15060	COG4221	oxidoreductase activity
HQ398_RS15080	COG1285	pathogenesis
HQ398_RS15100	COG1368	sulfuric ester hydrolase activity
HQ398_RS15105	COG1522	sequence-specific DNA binding
HQ398_RS15115	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HQ398_RS15120	COG1418	mRNA catabolic process
HQ398_RS15125	COG1058	Belongs to the CinA family
HQ398_RS15125	COG1546	Belongs to the CinA family
HQ398_RS15135	COG0561	phosphatase activity
HQ398_RS15145	COG2926	Belongs to the UPF0265 family
HQ398_RS15175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HQ398_RS15180	COG0564	pseudouridine synthase activity
HQ398_RS15190	COG0110	maltose O-acetyltransferase activity
HQ398_RS15195	COG0366	Alpha amylase catalytic
HQ398_RS15200	COG1263	PTS System
HQ398_RS15200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQ398_RS15220	COG0252	asparaginase activity
HQ398_RS15225	COG1253	flavin adenine dinucleotide binding
HQ398_RS15230	COG0586	Pfam SNARE associated Golgi protein
HQ398_RS15235	COG1686	Belongs to the peptidase S11 family
HQ398_RS15270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HQ398_RS15275	COG0527	aspartate kinase activity
HQ398_RS15280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HQ398_RS15290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HQ398_RS15295	COG1546	Belongs to the CinA family
HQ398_RS15300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HQ398_RS15305	COG4667	esterase of the alpha-beta hydrolase superfamily
HQ398_RS15315	COG1346	cytolysis
HQ398_RS15320	COG1380	Effector of murein hydrolase LrgA
HQ398_RS15340	COG0583	DNA-binding transcription factor activity
HQ398_RS15365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HQ398_RS15375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HQ398_RS15380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HQ398_RS15390	COG0137	argininosuccinate synthase activity
HQ398_RS15395	COG0165	Argininosuccinate lyase
HQ398_RS15410	COG3314	Sporulation integral membrane protein YlbJ
HQ398_RS15435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HQ398_RS15440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HQ398_RS15455	COG0477	Major facilitator Superfamily
HQ398_RS15460	COG0523	cobalamin synthesis protein
HQ398_RS15470	COG2200	EAL domain
HQ398_RS15475	COG1049	propionate catabolic process, 2-methylcitrate cycle
HQ398_RS15480	COG1752	Esterase of the alpha-beta hydrolase superfamily
HQ398_RS15485	COG0840	transmembrane signaling receptor activity
HQ398_RS15495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQ398_RS15500	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ398_RS15505	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HQ398_RS15510	COG2186	Transcriptional regulator
HQ398_RS15535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ398_RS15540	COG1459	type II secretion system
HQ398_RS15555	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HQ398_RS15560	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HQ398_RS15565	COG0494	nUDIX hydrolase
HQ398_RS15570	COG0653	protein targeting
HQ398_RS15580	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HQ398_RS15585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HQ398_RS15590	COG0849	cell division
HQ398_RS15600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQ398_RS15610	COG0772	Belongs to the SEDS family
HQ398_RS15615	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HQ398_RS15620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HQ398_RS15625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HQ398_RS15630	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HQ398_RS15635	COG0768	penicillin binding
HQ398_RS15640	COG3116	cell division
HQ398_RS15645	COG0275	rRNA processing
HQ398_RS15650	COG2001	Belongs to the MraZ family
HQ398_RS15660	COG0741	lytic transglycosylase activity
HQ398_RS15660	COG1388	LysM domain
HQ398_RS15675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HQ398_RS15680	COG1191	sigma factor activity
HQ398_RS15705	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HQ398_RS15710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ398_RS15715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ398_RS15730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HQ398_RS15735	COG1256	bacterial-type flagellum assembly
HQ398_RS15735	COG4786	Flagellar basal body rod
HQ398_RS15745	COG1706	bacterial-type flagellum-dependent cell motility
HQ398_RS15750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HQ398_RS15755	COG4786	Flagellar basal body rod
HQ398_RS15780	COG1815	bacterial-type flagellum-dependent cell motility
HQ398_RS15790	COG2747	anti-sigma28 factor FlgM
HQ398_RS15815	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HQ398_RS15825	COG1677	Flagellar hook-basal body complex protein FliE
HQ398_RS15875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HQ398_RS15880	COG3107	peptidoglycan biosynthetic process
HQ398_RS15885	COG0792	nuclease activity
HQ398_RS15890	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HQ398_RS15900	COG2969	positive regulation of protein catabolic process
HQ398_RS15905	COG0625	glutathione transferase activity
HQ398_RS15910	COG2857	Cytochrome c1
HQ398_RS15915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HQ398_RS15925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HQ398_RS15930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HQ398_RS15935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HQ398_RS15945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ398_RS15950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ398_RS15980	COG3964	amidohydrolase
HQ398_RS15995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS15995	COG3711	transcriptional antiterminator
HQ398_RS16000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS16005	COG1660	Displays ATPase and GTPase activities
HQ398_RS16010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS16020	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HQ398_RS16025	COG1137	ATPase activity
HQ398_RS16030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HQ398_RS16040	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HQ398_RS16045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HQ398_RS16045	COG0517	IMP dehydrogenase activity
HQ398_RS16050	COG1127	ABC transporter
HQ398_RS16055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQ398_RS16060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HQ398_RS16065	COG2854	intermembrane phospholipid transfer
HQ398_RS16075	COG5007	Belongs to the BolA IbaG family
HQ398_RS16080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HQ398_RS16085	COG0312	modulator of DNA gyrase
HQ398_RS16090	COG3028	Belongs to the UPF0307 family
HQ398_RS16095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HQ398_RS16105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQ398_RS16110	COG1011	Hydrolase
HQ398_RS16125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HQ398_RS16130	COG0019	diaminopimelate decarboxylase activity
HQ398_RS16140	COG1965	Belongs to the frataxin family
HQ398_RS16145	COG0400	carboxylic ester hydrolase activity
HQ398_RS16150	COG3072	Adenylate cyclase
HQ398_RS16155	COG0181	hydroxymethylbilane synthase activity
HQ398_RS16165	COG2959	enzyme of heme biosynthesis
HQ398_RS16180	COG1494	fructose-1,6-bisphosphatase
HQ398_RS16205	COG1686	Belongs to the peptidase S11 family
HQ398_RS16235	COG2932	Transcriptional regulator
HQ398_RS16330	COG4695	Portal protein
HQ398_RS16470	COG0795	lipopolysaccharide-transporting ATPase activity
HQ398_RS16475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQ398_RS16480	COG2927	DNA polymerase III (CHI subunit)
HQ398_RS16505	COG0454	-acetyltransferase
HQ398_RS16505	COG0456	acetyltransferase
HQ398_RS16530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HQ398_RS16535	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HQ398_RS16540	COG5380	lipid catabolic process
HQ398_RS16565	COG2873	o-acetylhomoserine
HQ398_RS16595	COG3842	ATPase activity
HQ398_RS16605	COG1176	ABC-type spermidine putrescine transport system, permease component I
HQ398_RS16630	COG3069	C4-dicarboxylate transmembrane transporter activity
HQ398_RS16645	COG2199	diguanylate cyclase activity
HQ398_RS16645	COG2203	Gaf domain
HQ398_RS16660	COG1074	ATP-dependent DNA helicase activity
HQ398_RS16670	COG2259	Doxx family
HQ398_RS16675	COG1741	Belongs to the pirin family
HQ398_RS16685	COG0583	DNA-binding transcription factor activity
HQ398_RS16710	COG4771	TonB-dependent receptor
HQ398_RS16750	COG0203	ribosomal protein L17
HQ398_RS16755	COG0202	RNA polymerase activity
HQ398_RS16760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HQ398_RS16765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HQ398_RS16770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HQ398_RS16775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HQ398_RS16780	COG0201	protein transport
HQ398_RS16785	COG0200	Binds to the 23S rRNA
HQ398_RS16790	COG1841	ribosomal large subunit assembly
HQ398_RS16795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HQ398_RS16800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HQ398_RS16805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HQ398_RS16810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HQ398_RS16815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HQ398_RS16820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HQ398_RS16825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HQ398_RS16830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HQ398_RS16835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HQ398_RS16840	COG0255	Belongs to the universal ribosomal protein uL29 family
HQ398_RS16845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HQ398_RS16850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HQ398_RS16855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HQ398_RS16860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HQ398_RS16865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HQ398_RS16870	COG0089	rRNA binding
HQ398_RS16875	COG0088	Forms part of the polypeptide exit tunnel
HQ398_RS16880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HQ398_RS16885	COG0051	transcription antitermination factor activity, RNA binding
HQ398_RS16905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HQ398_RS16910	COG2183	response to ionizing radiation
HQ398_RS16930	COG0596	Alpha beta hydrolase
HQ398_RS16935	COG1040	competence protein
HQ398_RS16940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HQ398_RS16940	COG0316	Belongs to the HesB IscA family
HQ398_RS16950	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HQ398_RS16955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ398_RS16960	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HQ398_RS16965	COG4942	peptidase
HQ398_RS16990	COG0800	Aldolase
HQ398_RS17000	COG3265	gluconokinase activity
HQ398_RS17005	COG2610	gluconate transmembrane transporter activity
HQ398_RS17010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HQ398_RS17015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HQ398_RS17025	COG0456	acetyltransferase
HQ398_RS17030	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HQ398_RS17035	COG1490	D-aminoacyl-tRNA deacylase activity
HQ398_RS17050	COG3385	transposase activity
HQ398_RS17055	COG3385	transposase activity
HQ398_RS17065	COG1295	ribonuclease BN
HQ398_RS17075	COG0814	amino acid
HQ398_RS17080	COG0702	epimerase
HQ398_RS17090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HQ398_RS17095	COG0254	rRNA binding
HQ398_RS17110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HQ398_RS17115	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HQ398_RS17125	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HQ398_RS17135	COG0514	ATP-dependent DNA helicase (RecQ)
HQ398_RS17140	COG2050	protein possibly involved in aromatic compounds catabolism
HQ398_RS17155	COG2258	MOSC domain
HQ398_RS17160	COG1177	transmembrane transport
HQ398_RS17165	COG1176	ABC-type spermidine putrescine transport system, permease component I
HQ398_RS17170	COG3842	ATPase activity
HQ398_RS17190	COG0174	glutamine synthetase
HQ398_RS17210	COG3045	CreA protein
HQ398_RS17215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ398_RS17220	COG0443	Heat shock 70 kDa protein
HQ398_RS17235	COG0366	Alpha amylase catalytic
HQ398_RS17250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQ398_RS17275	COG3250	beta-galactosidase activity
HQ398_RS17280	COG1609	Transcriptional regulator
HQ398_RS17285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HQ398_RS17290	COG1085	galactose-1-phosphate uridylyltransferase
HQ398_RS17295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HQ398_RS17300	COG2017	converts alpha-aldose to the beta-anomer
HQ398_RS17305	COG1968	undecaprenyl-diphosphatase activity
HQ398_RS17315	COG1595	DNA-templated transcription, initiation
HQ398_RS17335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HQ398_RS17340	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HQ398_RS17350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_RS17360	COG0842	Transport permease protein
HQ398_RS17365	COG0842	Transport permease protein
HQ398_RS17370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQ398_RS17380	COG2116	formate transmembrane transporter activity
HQ398_RS17385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQ398_RS17385	COG1648	precorrin-2 dehydrogenase activity
HQ398_RS17390	COG3177	Filamentation induced by cAMP protein fic
HQ398_RS17400	COG2239	Acts as a magnesium transporter
HQ398_RS17405	COG1079	Belongs to the binding-protein-dependent transport system permease family
HQ398_RS17410	COG4603	Belongs to the binding-protein-dependent transport system permease family
HQ398_RS17415	COG3845	ABC transporter
HQ398_RS17420	COG1744	ABC transporter substrate-binding protein PnrA-like
HQ398_RS17425	COG0210	DNA helicase
HQ398_RS17440	COG2856	Zn peptidase
HQ398_RS17485	COG1280	lysine exporter protein (LysE YggA)
HQ398_RS17510	COG3306	glycosyltransferase involved in LPS biosynthesis
HQ398_RS17530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ398_RS17540	COG0156	8-amino-7-oxononanoate synthase activity
HQ398_RS17545	COG1063	alcohol dehydrogenase
HQ398_RS17550	COG3245	cytochrome
HQ398_RS17565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HQ398_RS17570	COG2166	iron-sulfur cluster assembly
HQ398_RS17575	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HQ398_RS17615	COG4206	TonB-dependent receptor
HQ398_RS17620	COG0583	DNA-binding transcription factor activity
HQ398_RS17635	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HQ398_RS17640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HQ398_RS17645	COG2223	nitrite transmembrane transporter activity
HQ398_RS17650	COG3279	Response regulator of the LytR AlgR family
HQ398_RS17655	COG3275	phosphorelay sensor kinase activity
HQ398_RS17660	COG2081	HI0933 family
HQ398_RS17665	COG1528	Iron-storage protein
HQ398_RS17670	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HQ398_RS17675	COG0589	response to stress
HQ398_RS17715	COG3642	lipopolysaccharide core region biosynthetic process
HQ398_RS17720	COG0859	PFAM glycosyl transferase family 9
HQ398_RS17730	COG1758	RNA polymerase activity
HQ398_RS17735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HQ398_RS17740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQ398_RS17755	COG0561	phosphatase activity
HQ398_RS17790	COG1309	transcriptional regulator
HQ398_RS17795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ398_RS17800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQ398_RS17805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_RS17805	COG4191	Histidine kinase
HQ398_RS17810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQ398_RS17830	COG2205	protein histidine kinase activity
HQ398_RS17835	COG0745	RESPONSE REGULATOR receiver
HQ398_RS17840	COG2814	Major facilitator Superfamily
HQ398_RS17850	COG3977	Valine--pyruvate aminotransferase
HQ398_RS17855	COG0071	Belongs to the small heat shock protein (HSP20) family
HQ398_RS17860	COG0071	Belongs to the small heat shock protein (HSP20) family
HQ398_RS17865	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HQ398_RS17875	COG2378	regulation of single-species biofilm formation
HQ398_RS17895	COG0592	DNA-directed DNA polymerase activity
HQ398_RS17900	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HQ398_RS17915	COG1126	abc transporter atp-binding protein
HQ398_RS17920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HQ398_RS17925	COG0594	ribonuclease P activity
HQ398_RS17930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HQ398_RS17935	COG0706	membrane insertase activity
HQ398_RS17940	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HQ398_RS17945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HQ398_RS17950	COG0445	tRNA wobble uridine modification
HQ398_RS17955	COG0357	Ribosomal RNA small subunit methyltransferase G
HQ398_RS17960	COG1192	Involved in chromosome partitioning
HQ398_RS17965	COG1475	DNA binding
HQ398_RS17975	COG0356	it plays a direct role in the translocation of protons across the membrane
HQ398_RS17985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HQ398_RS17990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HQ398_RS17995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HQ398_RS18000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HQ398_RS18005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HQ398_RS18010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HQ398_RS18015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HQ398_RS18020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQ398_RS18065	COG0297	glycogen (starch) synthase activity
HQ398_RS18065	COG0438	transferase activity, transferring glycosyl groups
HQ398_RS18080	COG4452	Inner membrane protein CreD
HQ398_RS18100	COG0745	RESPONSE REGULATOR receiver
HQ398_RS18105	COG1349	DNA-binding transcription factor activity
HQ398_RS18110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HQ398_RS18115	COG2771	luxR family
HQ398_RS18125	COG0811	peptide transport
HQ398_RS18130	COG0811	peptide transport
HQ398_RS18135	COG0848	biopolymer transport protein
HQ398_RS18140	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HQ398_RS18175	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HQ398_RS18180	COG0402	S-adenosylhomocysteine deaminase activity
HQ398_RS18185	COG2226	methyltransferase
HQ398_RS18195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HQ398_RS18205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQ398_RS18210	COG0805	protein transport
HQ398_RS18215	COG0084	hydrolase, TatD family'
HQ398_RS18240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_RS18245	COG0742	ribosomal rna small subunit methyltransferase
HQ398_RS18255	COG0248	Ppx GppA phosphatase
HQ398_RS18260	COG0513	Belongs to the DEAD box helicase family
HQ398_RS18265	COG3118	belongs to the thioredoxin family
HQ398_RS18280	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HQ398_RS18295	COG2960	long-chain fatty acid transporting porin activity
HQ398_RS18305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ398_RS18350	COG4251	negative regulation of phosphorylation
HQ398_RS18350	COG5001	Diguanylate cyclase
HQ398_RS18350	COG2203	Gaf domain
HQ398_RS18350	COG3706	GGDEF domain
HQ398_RS18360	COG0751	glycine-tRNA ligase activity
HQ398_RS18365	COG0752	glycyl-tRNA synthetase alpha subunit
HQ398_RS18370	COG2818	Glycosylase
HQ398_RS18375	COG0840	transmembrane signaling receptor activity
HQ398_RS18380	COG2885	chlorophyll binding
HQ398_RS18385	COG0251	oxidation-reduction process
HQ398_RS18390	COG0425	Belongs to the sulfur carrier protein TusA family
HQ398_RS18415	COG0183	Belongs to the thiolase family
HQ398_RS18420	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQ398_RS18420	COG1024	Enoyl-CoA hydratase
HQ398_RS18425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HQ398_RS18430	COG0006	proline dipeptidase activity
HQ398_RS18435	COG1739	Uncharacterized protein family UPF0029
HQ398_RS18440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HQ398_RS18445	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HQ398_RS18495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HQ398_RS18500	COG0166	Belongs to the GPI family
HQ398_RS18505	COG0668	transmembrane transport
HQ398_RS18510	COG1309	transcriptional regulator
HQ398_RS18515	COG0756	dUTP diphosphatase activity
HQ398_RS18520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HQ398_RS18525	COG2003	Belongs to the UPF0758 family
HQ398_RS18530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HQ398_RS18535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HQ398_RS18545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HQ398_RS18550	COG2990	Protein conserved in bacteria
HQ398_RS18555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HQ398_RS18560	COG0859	PFAM glycosyl transferase family 9
HQ398_RS18565	COG0463	Glycosyl transferase, family 2
HQ398_RS18570	COG0859	PFAM glycosyl transferase family 9
HQ398_RS18575	COG1519	Transferase
HQ398_RS18590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQ398_RS18595	COG1609	Transcriptional regulator
HQ398_RS18600	COG0604	alcohol dehydrogenase
HQ398_RS18615	COG1580	Controls the rotational direction of flagella during chemotaxis
HQ398_RS18620	COG3161	chorismate lyase activity
HQ398_RS18625	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HQ398_RS18630	COG2937	Belongs to the GPAT DAPAT family
HQ398_RS18635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HQ398_RS18650	COG0534	Mate efflux family protein
HQ398_RS18655	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HQ398_RS18660	COG2205	protein histidine kinase activity
HQ398_RS18665	COG0745	RESPONSE REGULATOR receiver
HQ398_RS18675	COG1045	serine acetyltransferase
HQ398_RS18685	COG3074	FtsZ-dependent cytokinesis
HQ398_RS18690	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HQ398_RS18700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HQ398_RS18735	COG1609	Transcriptional regulator
HQ398_RS18740	COG3250	beta-galactosidase activity
HQ398_RS18745	COG2731	YhcH YjgK YiaL family protein
HQ398_RS18750	COG0531	amino acid
HQ398_RS18755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ398_RS18760	COG0531	amino acid
HQ398_RS18765	COG0385	Bile acid
HQ398_RS18805	COG0583	DNA-binding transcription factor activity
HQ398_RS18820	COG0583	DNA-binding transcription factor activity
HQ398_RS18825	COG1561	YicC-like family, N-terminal region
HQ398_RS18830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HQ398_RS18835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HQ398_RS18850	COG2203	Gaf domain
HQ398_RS18850	COG4251	negative regulation of phosphorylation
HQ398_RS18850	COG5001	Diguanylate cyclase
HQ398_RS18850	COG3706	GGDEF domain
HQ398_RS18855	COG3084	Protein conserved in bacteria
HQ398_RS18865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HQ398_RS18870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HQ398_RS18880	COG1335	isochorismatase
HQ398_RS18890	COG1683	Conserved Protein
HQ398_RS18895	COG0204	Acyl-transferase
HQ398_RS18900	COG0204	Acyl-transferase
HQ398_RS18905	COG0606	chelatase, subunit chli
HQ398_RS18915	COG3978	acetolactate synthase activity
HQ398_RS18925	COG0129	dihydroxy-acid dehydratase activity
HQ398_RS18935	COG1401	restriction endodeoxyribonuclease activity
HQ398_RS18940	COG1401	restriction endodeoxyribonuclease activity
HQ398_RS18980	COG2391	methyltransferase activity
HQ398_RS18985	COG2962	Rard protein
HQ398_RS18995	COG1012	belongs to the aldehyde dehydrogenase family
HQ398_RS19020	COG0583	DNA-binding transcription factor activity
HQ398_RS19045	COG1322	Protein conserved in bacteria
HQ398_RS19055	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HQ398_RS19075	COG0174	glutamine synthetase
HQ398_RS19080	COG1217	gtp-binding protein TYPA
HQ398_RS19085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HQ398_RS19090	COG0569	domain protein
HQ398_RS19095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ398_RS19095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ398_RS19100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HQ398_RS19105	COG0242	peptide deformylase activity
HQ398_RS19110	COG1652	LysM domain
HQ398_RS19115	COG0758	DNA mediated transformation
HQ398_RS19120	COG2922	Belongs to the Smg family
HQ398_RS19125	COG0551	DNA topoisomerase type I activity
HQ398_RS19135	COG0009	L-threonylcarbamoyladenylate synthase
HQ398_RS19140	COG0408	coproporphyrinogen oxidase activity
HQ398_RS19145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HQ398_RS19155	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HQ398_RS19165	COG3078	GTPase activator activity
HQ398_RS19205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HQ398_RS19210	COG1288	antiporter activity
HQ398_RS19215	COG1438	arginine binding
HQ398_RS19220	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HQ398_RS19225	COG0540	Belongs to the ATCase OTCase family
HQ398_RS19240	COG0688	phosphatidylethanolamine metabolic process
HQ398_RS19245	COG0583	DNA-binding transcription factor activity
HQ398_RS19265	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HQ398_RS19280	COG3040	lipid binding
HQ398_RS19285	COG2207	Transcriptional regulator
HQ398_RS19290	COG1979	alcohol dehydrogenase
HQ398_RS19295	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HQ398_RS19300	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HQ398_RS19310	COG3681	Belongs to the UPF0597 family
HQ398_RS19320	COG0446	pyridine nucleotide-disulphide oxidoreductase
HQ398_RS19325	COG2076	Multidrug Resistance protein
HQ398_RS19330	COG2076	Multidrug Resistance protein
HQ398_RS19335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HQ398_RS19340	COG0726	polysaccharide deacetylase
HQ398_RS19350	COG0463	Glycosyl transferase, family 2
HQ398_RS19355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HQ398_RS19360	COG3385	transposase activity
HQ398_RS19380	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ398_RS19385	COG0564	pseudouridine synthase activity
HQ398_RS19395	COG0542	response to heat
HQ398_RS19400	COG2502	aspartate--ammonia ligase
HQ398_RS19405	COG1522	sequence-specific DNA binding
HQ398_RS19415	COG5413	integral membrane protein
HQ398_RS19435	COG2205	protein histidine kinase activity
HQ398_RS19445	COG2204	response regulator
HQ398_RS19460	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HQ398_RS19490	COG0243	molybdopterin cofactor binding
HQ398_RS19495	COG3005	denitrification pathway
HQ398_RS19500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_RS19500	COG4191	Histidine kinase
HQ398_RS19510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HQ398_RS19515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HQ398_RS19520	COG0569	domain protein
HQ398_RS19525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HQ398_RS19550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HQ398_RS19565	COG0250	Participates in transcription elongation, termination and antitermination
HQ398_RS19570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HQ398_RS19575	COG0081	regulation of translation
HQ398_RS19580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HQ398_RS19585	COG0222	ribosome binding
HQ398_RS19590	COG0085	RNA polymerase activity
HQ398_RS19595	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HQ398_RS19600	COG2964	Protein conserved in bacteria
HQ398_RS19610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HQ398_RS19615	COG2923	Belongs to the DsrF TusC family
HQ398_RS19620	COG2168	tRNA wobble position uridine thiolation
HQ398_RS19625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HQ398_RS19630	COG0049	tRNA binding
HQ398_RS19635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HQ398_RS19640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HQ398_RS19645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HQ398_RS19715	COG0583	DNA-binding transcription factor activity
HQ398_RS19725	COG1301	dicarboxylic acid transport
HQ398_RS19735	COG2095	MarC family integral membrane protein
HQ398_RS19745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQ398_RS19765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HQ398_RS19780	COG1770	oligopeptidase
HQ398_RS19795	COG4221	oxidoreductase activity
HQ398_RS19800	COG0583	DNA-binding transcription factor activity
HQ398_RS19805	COG2249	NAD(P)H dehydrogenase (quinone) activity
HQ398_RS19830	COG0742	ribosomal rna small subunit methyltransferase
HQ398_RS19835	COG0552	protein localization to endoplasmic reticulum
HQ398_RS19840	COG2884	Cell division ATP-binding protein ftsE
HQ398_RS19845	COG2177	Part of the ABC transporter FtsEX involved in
HQ398_RS19855	COG0288	reversible hydration of carbon dioxide
HQ398_RS19860	COG2188	Transcriptional regulator
HQ398_RS19865	COG1228	amidohydrolase
HQ398_RS19870	COG0010	Belongs to the arginase family
HQ398_RS19875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HQ398_RS19880	COG2986	histidine ammonia-lyase
HQ398_RS19885	COG0387	Pfam Sodium calcium exchanger
HQ398_RS19895	COG2200	EAL domain
HQ398_RS19900	COG2200	EAL domain
HQ398_RS19900	COG2199	diguanylate cyclase activity
HQ398_RS19945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ398_RS19950	COG1459	type II secretion system
HQ398_RS19965	COG2165	general secretion pathway protein
HQ398_RS19995	COG1077	Cell shape determining protein MreB Mrl
HQ398_RS20000	COG1792	Involved in formation and maintenance of cell shape
HQ398_RS20005	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HQ398_RS20010	COG0424	maF-like protein
HQ398_RS20015	COG1530	ribonuclease E activity
HQ398_RS20020	COG3164	Protein of unknown function
HQ398_RS20030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQ398_RS20035	COG0312	modulator of DNA gyrase
HQ398_RS20050	COG0477	Major facilitator Superfamily
HQ398_RS20090	COG0646	methionine synthase
HQ398_RS20090	COG1410	methionine synthase
HQ398_RS20095	COG0189	ligase activity
HQ398_RS20100	COG0642	Histidine kinase
HQ398_RS20105	COG0745	RESPONSE REGULATOR receiver
HQ398_RS20120	COG0789	Transcriptional regulator
HQ398_RS20125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HQ398_RS20130	COG0352	thiamine-phosphate diphosphorylase activity
HQ398_RS20135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HQ398_RS20145	COG2022	thiamine diphosphate biosynthetic process
HQ398_RS20150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQ398_RS20155	COG1943	Transposase
HQ398_RS20175	COG0110	maltose O-acetyltransferase activity
HQ398_RS20190	COG0814	amino acid
HQ398_RS20195	COG3932	Exopolysaccharide synthesis, ExoD
HQ398_RS20210	COG0004	ammonium transporteR
HQ398_RS20215	COG3133	Outer membrane lipoprotein
HQ398_RS20220	COG0456	acetyltransferase
HQ398_RS20245	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HQ398_RS20250	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HQ398_RS20265	COG0671	phosphoesterase, PA-phosphatase related
HQ398_RS20270	COG0628	permease
HQ398_RS20280	COG2957	Belongs to the agmatine deiminase family
HQ398_RS20285	COG3284	Transcriptional regulator
HQ398_RS20300	COG1461	Dihydroxyacetone kinase
HQ398_RS20305	COG2376	Dihydroxyacetone kinase
HQ398_RS20310	COG2252	PERMEase
HQ398_RS20330	COG0629	single-stranded DNA binding
HQ398_RS20335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HQ398_RS20345	COG3047	cAMP biosynthetic process
HQ398_RS20350	COG0840	transmembrane signaling receptor activity
HQ398_RS20375	COG3135	benzoate transporter
HQ398_RS20380	COG1396	sequence-specific DNA binding
HQ398_RS20415	COG0045	succinate-CoA ligase (ADP-forming) activity
HQ398_RS20415	COG1042	CoA-binding domain protein
HQ398_RS20415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ398_RS20440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQ398_RS20445	COG0038	chloride channel
HQ398_RS20455	COG0316	Belongs to the HesB IscA family
HQ398_RS20460	COG1757	Na H antiporter
HQ398_RS20500	COG0297	glycogen (starch) synthase activity
HQ398_RS20505	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HQ398_RS20515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ398_RS20520	COG3025	triphosphatase activity
HQ398_RS20525	COG1392	Phosphate transport regulator
HQ398_RS20530	COG0306	phosphate transporter
HQ398_RS20535	COG0527	aspartate kinase activity
HQ398_RS20535	COG0460	homoserine dehydrogenase
HQ398_RS20540	COG0626	cystathionine gamma-synthase activity
HQ398_RS20555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ398_RS20560	COG0814	amino acid
HQ398_RS20565	COG1218	3'(2'),5'-bisphosphate nucleotidase
HQ398_RS20570	COG0494	nUDIX hydrolase
HQ398_RS20575	COG1011	Hydrolase
HQ398_RS20590	COG0110	maltose O-acetyltransferase activity
HQ398_RS20600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HQ398_RS20610	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HQ398_RS20615	COG4208	sulfate ABC transporter
HQ398_RS20620	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HQ398_RS20625	COG0583	DNA-binding transcription factor activity
HQ398_RS20635	COG0765	amino acid transport
HQ398_RS20645	COG1126	abc transporter atp-binding protein
HQ398_RS20650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_RS20655	COG3397	chitin binding
HQ398_RS20660	COG0840	transmembrane signaling receptor activity
HQ398_RS20675	COG1649	PFAM Uncharacterised BCR, COG1649
HQ398_RS20675	COG0726	polysaccharide deacetylase
HQ398_RS20680	COG1215	transferase activity, transferring glycosyl groups
HQ398_RS20710	COG1328	CTP reductase activity
HQ398_RS20715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQ398_RS20730	COG1448	Aminotransferase
HQ398_RS20735	COG2194	sulfuric ester hydrolase activity
HQ398_RS20750	COG1215	transferase activity, transferring glycosyl groups
HQ398_RS20755	COG1215	transferase activity, transferring glycosyl groups
HQ398_RS20760	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HQ398_RS20765	COG3118	belongs to the thioredoxin family
HQ398_RS20765	COG0457	Tetratricopeptide repeat
HQ398_RS20805	COG0513	Belongs to the DEAD box helicase family
HQ398_RS20835	COG3112	Uncharacterised protein family (UPF0231)
HQ398_RS20840	COG3835	regulator
HQ398_RS20845	COG2610	gluconate transmembrane transporter activity
HQ398_RS20850	COG1929	Belongs to the glycerate kinase type-1 family
HQ398_RS20865	COG0583	DNA-binding transcription factor activity
HQ398_RS20870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ398_RS20880	COG1872	DUF167
HQ398_RS20885	COG0762	integral membrane protein
HQ398_RS20890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HQ398_RS20895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HQ398_RS20910	COG3022	response to hydroperoxide
HQ398_RS20930	COG0347	Belongs to the P(II) protein family
HQ398_RS20935	COG1840	ABC-type Fe3 transport system, periplasmic component
HQ398_RS20945	COG3842	ATPase activity
HQ398_RS20950	COG2837	iron assimilation
HQ398_RS20955	COG1438	arginine binding
HQ398_RS20960	COG1126	abc transporter atp-binding protein
HQ398_RS20965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQ398_RS20970	COG4215	(ABC) transporter
HQ398_RS20975	COG4160	amino acid transport
HQ398_RS20980	COG0039	L-malate dehydrogenase activity
HQ398_RS20995	COG1017	nitric oxide dioxygenase activity
HQ398_RS20995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ398_RS21005	COG4536	flavin adenine dinucleotide binding
HQ398_RS21010	COG4137	Cytochrome C assembly protein
HQ398_RS21015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HQ398_RS21020	COG0228	four-way junction DNA binding
HQ398_RS21025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HQ398_RS21030	COG0336	Belongs to the RNA methyltransferase TrmD family
HQ398_RS21035	COG0335	large ribosomal subunit rRNA binding
HQ398_RS21050	COG1051	belongs to the nudix hydrolase family
HQ398_RS21060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HQ398_RS21065	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HQ398_RS21070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQ398_RS21080	COG0583	DNA-binding transcription factor activity
HQ398_RS21085	COG0640	Transcriptional regulator
HQ398_RS21090	COG0268	Binds directly to 16S ribosomal RNA
HQ398_RS21100	COG0196	riboflavin kinase activity
HQ398_RS21110	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HQ398_RS21115	COG1047	Peptidyl-prolyl cis-trans
HQ398_RS21120	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HQ398_RS21155	COG4969	Belongs to the N-Me-Phe pilin family
HQ398_RS21160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQ398_RS21160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HQ398_RS21175	COG1854	S-ribosylhomocysteine lyase activity
HQ398_RS21185	COG2165	general secretion pathway protein
HQ398_RS21190	COG0084	hydrolase, TatD family'
HQ398_RS21195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQ398_RS21205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HQ398_RS21210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HQ398_RS21215	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HQ398_RS21220	COG0813	purine-nucleoside phosphorylase activity
HQ398_RS21245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HQ398_RS21255	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HQ398_RS21260	COG0776	regulation of translation
HQ398_RS21275	COG1914	H( )-stimulated, divalent metal cation uptake system
HQ398_RS21280	COG0360	Binds together with S18 to 16S ribosomal RNA
HQ398_RS21285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HQ398_RS21290	COG0359	binds to the 23S rRNA
HQ398_RS21295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ398_RS21315	COG4221	oxidoreductase activity
HQ398_RS21315	COG0604	alcohol dehydrogenase
HQ398_RS21315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HQ398_RS21315	COG3321	synthase
HQ398_RS21320	COG1238	metal cluster binding
HQ398_RS21325	COG0612	Peptidase, M16
HQ398_RS21330	COG2918	glutathione biosynthetic process
HQ398_RS21335	COG1022	Amp-dependent synthetase and ligase
HQ398_RS21340	COG0456	acetyltransferase
HQ398_RS21355	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HQ398_RS21370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HQ398_RS21380	COG0477	Major facilitator Superfamily
HQ398_RS21385	COG0583	DNA-binding transcription factor activity
HQ398_RS21395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ398_RS21400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ398_RS21410	COG0673	inositol 2-dehydrogenase activity
HQ398_RS21420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HQ398_RS21425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HQ398_RS21430	COG3036	rescue of stalled ribosome
HQ398_RS21445	COG0138	bifunctional purine biosynthesis protein purh
HQ398_RS21450	COG0151	Belongs to the GarS family
HQ398_RS21470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HQ398_RS21475	COG0358	DNA primase activity
HQ398_RS21480	COG1610	YqeY-like protein
HQ398_RS21485	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HQ398_RS21490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HQ398_RS21495	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HQ398_RS21500	COG1027	Aspartate ammonia-lyase
HQ398_RS21505	COG3030	protein affecting phage T7 exclusion by the F plasmid
HQ398_RS21510	COG0534	Mate efflux family protein
HQ398_RS21515	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HQ398_RS21520	COG0459	protein refolding
HQ398_RS21570	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HQ398_RS21575	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HQ398_RS21580	COG1178	ABC-type Fe3 transport system permease component
HQ398_RS21585	COG4143	(ABC) transporter
HQ398_RS21600	COG0066	3-isopropylmalate dehydratase activity
HQ398_RS21645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HQ398_RS21660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HQ398_RS21700	COG5001	Diguanylate cyclase
HQ398_RS21700	COG2203	Gaf domain
HQ398_RS21700	COG3706	GGDEF domain
HQ398_RS21700	COG4251	negative regulation of phosphorylation
HQ398_RS21710	COG0840	transmembrane signaling receptor activity
HQ398_RS21710	COG3290	protein histidine kinase activity
HQ398_RS21745	COG3300	MHYT domain
HQ398_RS21745	COG5001	Diguanylate cyclase
HQ398_RS21780	COG1397	ADP-ribosylglycohydrolase
HQ398_RS21785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HQ398_RS21790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HQ398_RS21850	COG5002	protein histidine kinase activity
HQ398_RS21850	COG5001	Diguanylate cyclase
HQ398_RS21855	COG0463	Glycosyl transferase, family 2
HQ398_RS21860	COG1215	transferase activity, transferring glycosyl groups