locus-tag	class	description
GWI30_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWI30_RS00010	COG0592	DNA-directed DNA polymerase activity
GWI30_RS00020	COG0187	DNA topoisomerase II activity
GWI30_RS00030	COG2378	regulation of single-species biofilm formation
GWI30_RS00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWI30_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
GWI30_RS00050	COG0071	Belongs to the small heat shock protein (HSP20) family
GWI30_RS00055	COG3977	Valine--pyruvate aminotransferase
GWI30_RS00070	COG2814	Major facilitator Superfamily
GWI30_RS00075	COG0745	RESPONSE REGULATOR receiver
GWI30_RS00080	COG2205	protein histidine kinase activity
GWI30_RS00100	COG1733	regulation of RNA biosynthetic process
GWI30_RS00105	COG2267	carboxylic ester hydrolase activity
GWI30_RS00110	COG0604	alcohol dehydrogenase
GWI30_RS00120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWI30_RS00125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWI30_RS00125	COG4191	Histidine kinase
GWI30_RS00130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWI30_RS00135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWI30_RS00140	COG1309	transcriptional regulator
GWI30_RS00170	COG0561	phosphatase activity
GWI30_RS00175	COG2267	carboxylic ester hydrolase activity
GWI30_RS00180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWI30_RS00190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWI30_RS00195	COG1758	RNA polymerase activity
GWI30_RS00205	COG0859	PFAM glycosyl transferase family 9
GWI30_RS00245	COG0589	response to stress
GWI30_RS00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWI30_RS00255	COG3706	GGDEF domain
GWI30_RS00260	COG1528	Iron-storage protein
GWI30_RS00265	COG2081	HI0933 family
GWI30_RS00270	COG2223	nitrite transmembrane transporter activity
GWI30_RS00290	COG3039	Transposase
GWI30_RS00315	COG3275	phosphorelay sensor kinase activity
GWI30_RS00320	COG3279	Response regulator of the LytR AlgR family
GWI30_RS00325	COG2223	nitrite transmembrane transporter activity
GWI30_RS00330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWI30_RS00335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWI30_RS00340	COG4206	TonB-dependent receptor
GWI30_RS00345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GWI30_RS00380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWI30_RS00385	COG2166	iron-sulfur cluster assembly
GWI30_RS00390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWI30_RS00395	COG0210	DNA helicase
GWI30_RS00400	COG3300	MHYT domain
GWI30_RS00400	COG5001	Diguanylate cyclase
GWI30_RS00410	COG1063	alcohol dehydrogenase
GWI30_RS00425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWI30_RS00430	COG0438	transferase activity, transferring glycosyl groups
GWI30_RS00435	COG3307	-O-antigen
GWI30_RS00450	COG5433	transposase activity
GWI30_RS00475	COG0604	alcohol dehydrogenase
GWI30_RS00485	COG1580	Controls the rotational direction of flagella during chemotaxis
GWI30_RS00490	COG3161	chorismate lyase activity
GWI30_RS00495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWI30_RS00505	COG2937	Belongs to the GPAT DAPAT family
GWI30_RS00510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWI30_RS00525	COG0534	Mate efflux family protein
GWI30_RS00530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GWI30_RS00535	COG2205	protein histidine kinase activity
GWI30_RS00540	COG0745	RESPONSE REGULATOR receiver
GWI30_RS00550	COG1045	serine acetyltransferase
GWI30_RS00560	COG3074	FtsZ-dependent cytokinesis
GWI30_RS00565	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GWI30_RS00570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWI30_RS00570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWI30_RS00575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWI30_RS00610	COG1609	Transcriptional regulator
GWI30_RS00615	COG4584	PFAM Integrase catalytic
GWI30_RS00620	COG1484	DNA-dependent DNA replication
GWI30_RS00625	COG3250	beta-galactosidase activity
GWI30_RS00630	COG2731	YhcH YjgK YiaL family protein
GWI30_RS00635	COG0531	amino acid
GWI30_RS00640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWI30_RS00645	COG0531	amino acid
GWI30_RS00650	COG0385	Bile acid
GWI30_RS00655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWI30_RS00675	COG0583	DNA-binding transcription factor activity
GWI30_RS00705	COG0210	DNA helicase
GWI30_RS00710	COG3039	Transposase
GWI30_RS00715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWI30_RS00750	COG2391	methyltransferase activity
GWI30_RS00755	COG1280	lysine exporter protein (LysE YggA)
GWI30_RS00765	COG2962	Rard protein
GWI30_RS00770	COG1012	belongs to the aldehyde dehydrogenase family
GWI30_RS00775	COG1396	sequence-specific DNA binding
GWI30_RS00790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWI30_RS00790	COG0519	Catalyzes the synthesis of GMP from XMP
GWI30_RS00800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWI30_RS00820	COG1322	Protein conserved in bacteria
GWI30_RS00825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWI30_RS00830	COG0569	domain protein
GWI30_RS00835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWI30_RS00835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWI30_RS00840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWI30_RS00845	COG0242	peptide deformylase activity
GWI30_RS00855	COG0758	DNA mediated transformation
GWI30_RS00860	COG2922	Belongs to the Smg family
GWI30_RS00865	COG0551	DNA topoisomerase type I activity
GWI30_RS00870	COG0009	L-threonylcarbamoyladenylate synthase
GWI30_RS00875	COG0408	coproporphyrinogen oxidase activity
GWI30_RS00880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWI30_RS00885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWI30_RS00895	COG3078	GTPase activator activity
GWI30_RS00905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWI30_RS00910	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWI30_RS00920	COG3852	Histidine kinase
GWI30_RS00930	COG0174	glutamine synthetase
GWI30_RS00940	COG1295	ribonuclease BN
GWI30_RS00945	COG1490	D-aminoacyl-tRNA deacylase activity
GWI30_RS00955	COG0456	acetyltransferase
GWI30_RS00965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWI30_RS00970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWI30_RS00975	COG2610	gluconate transmembrane transporter activity
GWI30_RS00980	COG3265	gluconokinase activity
GWI30_RS00985	COG0129	dihydroxy-acid dehydratase activity
GWI30_RS00990	COG0800	Aldolase
GWI30_RS00995	COG1609	Transcriptional regulator
GWI30_RS01005	COG4942	peptidase
GWI30_RS01010	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWI30_RS01015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWI30_RS01020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GWI30_RS01025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWI30_RS01030	COG0316	Belongs to the HesB IscA family
GWI30_RS01030	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWI30_RS01035	COG1040	competence protein
GWI30_RS01040	COG0596	Alpha beta hydrolase
GWI30_RS01055	COG2183	response to ionizing radiation
GWI30_RS01060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWI30_RS01065	COG0745	RESPONSE REGULATOR receiver
GWI30_RS01070	COG2205	protein histidine kinase activity
GWI30_RS01080	COG0051	transcription antitermination factor activity, RNA binding
GWI30_RS01085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWI30_RS01090	COG0088	Forms part of the polypeptide exit tunnel
GWI30_RS01095	COG0089	rRNA binding
GWI30_RS01100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWI30_RS01105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWI30_RS01110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWI30_RS01115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWI30_RS01120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWI30_RS01125	COG0255	Belongs to the universal ribosomal protein uL29 family
GWI30_RS01130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWI30_RS01135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWI30_RS01140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWI30_RS01145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWI30_RS01150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWI30_RS01155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWI30_RS01160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWI30_RS01165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GWI30_RS01170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWI30_RS01175	COG1841	ribosomal large subunit assembly
GWI30_RS01180	COG0200	Binds to the 23S rRNA
GWI30_RS01185	COG0201	protein transport
GWI30_RS01190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWI30_RS01195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWI30_RS01200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWI30_RS01205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWI30_RS01210	COG0202	RNA polymerase activity
GWI30_RS01215	COG0203	ribosomal protein L17
GWI30_RS01255	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GWI30_RS01260	COG2252	PERMEase
GWI30_RS01270	COG2376	Dihydroxyacetone kinase
GWI30_RS01275	COG1461	Dihydroxyacetone kinase
GWI30_RS01285	COG3284	Transcriptional regulator
GWI30_RS01295	COG0628	permease
GWI30_RS01320	COG0753	catalase activity
GWI30_RS01325	COG0454	-acetyltransferase
GWI30_RS01325	COG0456	acetyltransferase
GWI30_RS01330	COG2207	Transcriptional regulator
GWI30_RS01355	COG3842	ATPase activity
GWI30_RS01365	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWI30_RS01390	COG0583	DNA-binding transcription factor activity
GWI30_RS01400	COG1741	Belongs to the pirin family
GWI30_RS01405	COG2259	Doxx family
GWI30_RS01410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GWI30_RS01415	COG1074	ATP-dependent DNA helicase activity
GWI30_RS01420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWI30_RS01425	COG3039	Transposase
GWI30_RS01430	COG0346	lactoylglutathione lyase activity
GWI30_RS01440	COG0004	ammonium transporteR
GWI30_RS01445	COG0347	Belongs to the P(II) protein family
GWI30_RS01450	COG3706	GGDEF domain
GWI30_RS01470	COG0745	RESPONSE REGULATOR receiver
GWI30_RS01475	COG2205	protein histidine kinase activity
GWI30_RS01480	COG1278	Cold shock
GWI30_RS01495	COG0629	single-stranded DNA binding
GWI30_RS01500	COG2197	response regulator
GWI30_RS01505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWI30_RS01510	COG3039	Transposase
GWI30_RS01515	COG3047	cAMP biosynthetic process
GWI30_RS01540	COG1368	sulfuric ester hydrolase activity
GWI30_RS01570	COG4221	oxidoreductase activity
GWI30_RS01585	COG1979	alcohol dehydrogenase
GWI30_RS01595	COG2873	o-acetylhomoserine
GWI30_RS01620	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GWI30_RS01635	COG2949	membrane
GWI30_RS01645	COG0318	PFAM AMP-dependent synthetase and ligase
GWI30_RS01650	COG1441	menaquinone biosynthetic process
GWI30_RS01655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GWI30_RS01660	COG0596	Alpha beta hydrolase
GWI30_RS01665	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GWI30_RS01670	COG1169	isochorismate synthase
GWI30_RS01675	COG1575	Belongs to the MenA family. Type 1 subfamily
GWI30_RS01700	COG0513	Belongs to the DEAD box helicase family
GWI30_RS01710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWI30_RS01725	COG1671	Belongs to the UPF0178 family
GWI30_RS01750	COG3722	fumarate hydratase activity
GWI30_RS01755	COG0246	Mannitol dehydrogenase
GWI30_RS01760	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWI30_RS01760	COG2213	PTS system mannitol-specific
GWI30_RS01765	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GWI30_RS01780	COG2771	luxR family
GWI30_RS01795	COG1560	Kdo2-lipid A biosynthetic process
GWI30_RS01800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWI30_RS01800	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GWI30_RS01805	COG1538	Outer membrane efflux protein
GWI30_RS01810	COG0494	nUDIX hydrolase
GWI30_RS01815	COG3151	Protein conserved in bacteria
GWI30_RS01825	COG3150	esterase
GWI30_RS01830	COG1051	belongs to the nudix hydrolase family
GWI30_RS01840	COG0187	DNA topoisomerase II activity
GWI30_RS01860	COG3039	Transposase
GWI30_RS01885	COG0456	acetyltransferase
GWI30_RS01930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWI30_RS01950	COG0204	Acyl-transferase
GWI30_RS01955	COG1842	Phage shock protein A
GWI30_RS01975	COG2827	Endonuclease containing a URI domain
GWI30_RS01985	COG1573	uracil-dna glycosylase
GWI30_RS01995	COG0583	DNA-binding transcription factor activity
GWI30_RS02000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWI30_RS02005	COG1121	(ABC) transporter
GWI30_RS02010	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GWI30_RS02030	COG0739	heme binding
GWI30_RS02040	COG3068	Protein conserved in bacteria
GWI30_RS02060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWI30_RS02070	COG1546	Belongs to the CinA family
GWI30_RS02075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWI30_RS02090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWI30_RS02095	COG0527	aspartate kinase activity
GWI30_RS02100	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GWI30_RS02135	COG1686	Belongs to the peptidase S11 family
GWI30_RS02140	COG0586	Pfam SNARE associated Golgi protein
GWI30_RS02145	COG1253	flavin adenine dinucleotide binding
GWI30_RS02150	COG0525	valine-tRNA ligase activity
GWI30_RS02155	COG2927	DNA polymerase III (CHI subunit)
GWI30_RS02160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWI30_RS02165	COG0795	lipopolysaccharide-transporting ATPase activity
GWI30_RS02170	COG0795	lipopolysaccharide-transporting ATPase activity
GWI30_RS02190	COG0004	ammonium transporteR
GWI30_RS02195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWI30_RS02215	COG0084	hydrolase, TatD family'
GWI30_RS02220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWI30_RS02230	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWI30_RS02235	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GWI30_RS02240	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GWI30_RS02255	COG3064	Membrane
GWI30_RS02265	COG0560	Phosphoserine phosphatase
GWI30_RS02280	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWI30_RS02290	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GWI30_RS02295	COG0776	regulation of translation
GWI30_RS02305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWI30_RS02310	COG0735	belongs to the Fur family
GWI30_RS02330	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GWI30_RS02335	COG0513	Belongs to the DEAD box helicase family
GWI30_RS02340	COG3022	response to hydroperoxide
GWI30_RS02355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWI30_RS02360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWI30_RS02365	COG0762	integral membrane protein
GWI30_RS02370	COG1872	DUF167
GWI30_RS02390	COG3112	Uncharacterised protein family (UPF0231)
GWI30_RS02395	COG3835	regulator
GWI30_RS02400	COG2610	gluconate transmembrane transporter activity
GWI30_RS02405	COG1929	Belongs to the glycerate kinase type-1 family
GWI30_RS02420	COG0583	DNA-binding transcription factor activity
GWI30_RS02425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWI30_RS02440	COG0347	Belongs to the P(II) protein family
GWI30_RS02445	COG1840	ABC-type Fe3 transport system, periplasmic component
GWI30_RS02460	COG2837	iron assimilation
GWI30_RS02465	COG1438	arginine binding
GWI30_RS02470	COG1126	abc transporter atp-binding protein
GWI30_RS02475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWI30_RS02480	COG4215	(ABC) transporter
GWI30_RS02485	COG4160	amino acid transport
GWI30_RS02490	COG0039	L-malate dehydrogenase activity
GWI30_RS02495	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GWI30_RS02500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWI30_RS02500	COG1017	nitric oxide dioxygenase activity
GWI30_RS02510	COG4536	flavin adenine dinucleotide binding
GWI30_RS02515	COG4137	Cytochrome C assembly protein
GWI30_RS02520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWI30_RS02525	COG0228	four-way junction DNA binding
GWI30_RS02530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWI30_RS02535	COG0336	Belongs to the RNA methyltransferase TrmD family
GWI30_RS02540	COG0335	large ribosomal subunit rRNA binding
GWI30_RS02555	COG1051	belongs to the nudix hydrolase family
GWI30_RS02565	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GWI30_RS02570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWI30_RS02580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWI30_RS02590	COG0583	DNA-binding transcription factor activity
GWI30_RS02595	COG0640	Transcriptional regulator
GWI30_RS02600	COG0268	Binds directly to 16S ribosomal RNA
GWI30_RS02605	COG0728	peptidoglycan biosynthetic process
GWI30_RS02610	COG0196	riboflavin kinase activity
GWI30_RS02615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWI30_RS02620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWI30_RS02625	COG1047	Peptidyl-prolyl cis-trans
GWI30_RS02630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWI30_RS02650	COG5433	transposase activity
GWI30_RS02680	COG4584	PFAM Integrase catalytic
GWI30_RS02685	COG1484	DNA-dependent DNA replication
GWI30_RS02695	COG5433	transposase activity
GWI30_RS02700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWI30_RS02700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWI30_RS02715	COG1854	S-ribosylhomocysteine lyase activity
GWI30_RS02725	COG3706	GGDEF domain
GWI30_RS02730	COG0557	exoribonuclease II activity
GWI30_RS02745	COG2153	protein acetylation
GWI30_RS02760	COG1914	H( )-stimulated, divalent metal cation uptake system
GWI30_RS02765	COG0360	Binds together with S18 to 16S ribosomal RNA
GWI30_RS02770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWI30_RS02775	COG0359	binds to the 23S rRNA
GWI30_RS02790	COG3328	transposase activity
GWI30_RS02800	COG1064	alcohol dehydrogenase
GWI30_RS02805	COG1238	metal cluster binding
GWI30_RS02810	COG0612	Peptidase, M16
GWI30_RS02815	COG2918	glutathione biosynthetic process
GWI30_RS02820	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWI30_RS02825	COG1027	Aspartate ammonia-lyase
GWI30_RS02830	COG3030	protein affecting phage T7 exclusion by the F plasmid
GWI30_RS02840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWI30_RS02845	COG0459	protein refolding
GWI30_RS02865	COG0564	pseudouridine synthase activity
GWI30_RS02870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWI30_RS02910	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWI30_RS02915	COG4208	sulfate ABC transporter
GWI30_RS02920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWI30_RS02925	COG0583	DNA-binding transcription factor activity
GWI30_RS02935	COG3397	chitin binding
GWI30_RS02940	COG0840	transmembrane signaling receptor activity
GWI30_RS02965	COG1328	CTP reductase activity
GWI30_RS02970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWI30_RS02985	COG1448	Aminotransferase
GWI30_RS03015	COG1215	transferase activity, transferring glycosyl groups
GWI30_RS03025	COG0457	Tetratricopeptide repeat
GWI30_RS03025	COG3118	belongs to the thioredoxin family
GWI30_RS03050	COG5433	transposase activity
GWI30_RS03075	COG0513	Belongs to the DEAD box helicase family
GWI30_RS03090	COG3568	Endonuclease Exonuclease Phosphatase
GWI30_RS03095	COG0840	transmembrane signaling receptor activity
GWI30_RS03105	COG4166	transmembrane transport
GWI30_RS03120	COG1024	Enoyl-CoA hydratase
GWI30_RS03135	COG4221	oxidoreductase activity
GWI30_RS03140	COG0442	prolyl-tRNA aminoacylation
GWI30_RS03145	COG0632	four-way junction helicase activity
GWI30_RS03150	COG2255	four-way junction helicase activity
GWI30_RS03155	COG1271	oxidase subunit
GWI30_RS03160	COG1294	oxidase, subunit
GWI30_RS03165	COG4890	Cyd operon protein YbgT
GWI30_RS03170	COG3790	cyd operon protein YbgE
GWI30_RS03175	COG0824	Thioesterase
GWI30_RS03180	COG0811	peptide transport
GWI30_RS03195	COG0823	Involved in the tonB-independent uptake of proteins
GWI30_RS03200	COG2885	chlorophyll binding
GWI30_RS03205	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GWI30_RS03280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWI30_RS03290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWI30_RS03295	COG1640	4-alpha-glucanotransferase
GWI30_RS03300	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GWI30_RS03325	COG2130	NADP-dependent
GWI30_RS03330	COG1846	Transcriptional regulator
GWI30_RS03345	COG1522	sequence-specific DNA binding
GWI30_RS03360	COG0561	phosphatase activity
GWI30_RS03375	COG0733	neurotransmitter:sodium symporter activity
GWI30_RS03380	COG0733	neurotransmitter:sodium symporter activity
GWI30_RS03395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWI30_RS03410	COG1794	racemase activity, acting on amino acids and derivatives
GWI30_RS03420	COG1022	Amp-dependent synthetase and ligase
GWI30_RS03430	COG0456	acetyltransferase
GWI30_RS03445	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GWI30_RS03450	COG3300	MHYT domain
GWI30_RS03450	COG5001	Diguanylate cyclase
GWI30_RS03455	COG3706	GGDEF domain
GWI30_RS03455	COG0745	RESPONSE REGULATOR receiver
GWI30_RS03460	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GWI30_RS03470	COG1902	pentaerythritol trinitrate reductase activity
GWI30_RS03490	COG2957	Belongs to the agmatine deiminase family
GWI30_RS03495	COG0154	amidase activity
GWI30_RS03515	COG0513	Belongs to the DEAD box helicase family
GWI30_RS03520	COG3706	GGDEF domain
GWI30_RS03530	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GWI30_RS03585	COG4584	PFAM Integrase catalytic
GWI30_RS03590	COG1484	DNA-dependent DNA replication
GWI30_RS03605	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GWI30_RS03610	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GWI30_RS03615	COG1178	ABC-type Fe3 transport system permease component
GWI30_RS03620	COG4143	(ABC) transporter
GWI30_RS03635	COG0066	3-isopropylmalate dehydratase activity
GWI30_RS03640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWI30_RS03645	COG0473	3-isopropylmalate dehydrogenase activity
GWI30_RS03650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWI30_RS03660	COG0671	phosphoesterase, PA-phosphatase related
GWI30_RS03665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWI30_RS03670	COG0028	Belongs to the TPP enzyme family
GWI30_RS03675	COG0440	acetolactate synthase activity
GWI30_RS03680	COG0280	phosphate acetyltransferase
GWI30_RS03680	COG0857	belongs to the CobB CobQ family
GWI30_RS03685	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWI30_RS03690	COG3092	negative regulation of chromosome organization
GWI30_RS03695	COG3013	Belongs to the UPF0304 family
GWI30_RS03700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWI30_RS03705	COG2716	regulation of RNA biosynthetic process
GWI30_RS03710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWI30_RS03715	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GWI30_RS03720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWI30_RS03755	COG2198	Histidine kinase
GWI30_RS03755	COG0784	Response regulator, receiver
GWI30_RS03755	COG5002	protein histidine kinase activity
GWI30_RS03760	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GWI30_RS03770	COG5433	transposase activity
GWI30_RS03780	COG5001	Diguanylate cyclase
GWI30_RS03780	COG3300	MHYT domain
GWI30_RS03815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GWI30_RS03825	COG0488	(ABC) transporter
GWI30_RS03830	COG0517	IMP dehydrogenase activity
GWI30_RS03840	COG3385	transposase activity
GWI30_RS03850	COG3039	Transposase
GWI30_RS03855	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GWI30_RS03870	COG2755	lipolytic protein G-D-S-L family
GWI30_RS03875	COG4181	ATPase activity
GWI30_RS03880	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GWI30_RS03885	COG1090	epimerase
GWI30_RS03890	COG2200	EAL domain
GWI30_RS03895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWI30_RS03900	COG4935	Belongs to the peptidase S8 family
GWI30_RS03900	COG2234	aminopeptidase activity
GWI30_RS03905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWI30_RS03910	COG3171	Protein conserved in bacteria
GWI30_RS03915	COG2066	Belongs to the glutaminase family
GWI30_RS03920	COG2897	thiosulfate sulfurtransferase activity
GWI30_RS03930	COG1132	(ABC) transporter
GWI30_RS03960	COG0582	viral genome integration into host DNA
GWI30_RS03970	COG4974	Belongs to the 'phage' integrase family
GWI30_RS04015	COG5433	transposase activity
GWI30_RS04030	COG3385	transposase activity
GWI30_RS04045	COG3335	DDE superfamily endonuclease
GWI30_RS04075	COG3039	Transposase
GWI30_RS04085	COG2211	Major facilitator Superfamily
GWI30_RS04095	COG1609	Transcriptional regulator
GWI30_RS04105	COG2017	converts alpha-aldose to the beta-anomer
GWI30_RS04110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWI30_RS04120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWI30_RS04125	COG3291	Pkd domain containing protein
GWI30_RS04125	COG4412	M6 family metalloprotease domain protein
GWI30_RS04130	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GWI30_RS04140	COG5001	Diguanylate cyclase
GWI30_RS04140	COG3300	MHYT domain
GWI30_RS04155	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWI30_RS04170	COG4628	conserved protein (DUF2132)
GWI30_RS04175	COG0688	phosphatidylethanolamine metabolic process
GWI30_RS04185	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GWI30_RS04225	COG1278	Cold shock
GWI30_RS04235	COG0840	transmembrane signaling receptor activity
GWI30_RS04240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWI30_RS04245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWI30_RS04300	COG0848	biopolymer transport protein
GWI30_RS04305	COG0811	peptide transport
GWI30_RS04310	COG0811	peptide transport
GWI30_RS04320	COG4206	TonB-dependent receptor
GWI30_RS04325	COG5433	transposase activity
GWI30_RS04335	COG4174	ABC transporter (Permease)
GWI30_RS04340	COG4239	(ABC) transporter, permease
GWI30_RS04345	COG0747	negative chemotaxis
GWI30_RS04355	COG4608	Belongs to the ABC transporter superfamily
GWI30_RS04360	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWI30_RS04365	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GWI30_RS04385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GWI30_RS04410	COG0243	molybdopterin cofactor binding
GWI30_RS04425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWI30_RS04425	COG1116	anion transmembrane transporter activity
GWI30_RS04430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWI30_RS04435	COG1116	anion transmembrane transporter activity
GWI30_RS04440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWI30_RS04440	COG2146	nitrite reductase [NAD(P)H] activity
GWI30_RS04445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWI30_RS04445	COG2146	nitrite reductase [NAD(P)H] activity
GWI30_RS04450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWI30_RS04455	COG2313	pseudouridylate synthase activity
GWI30_RS04470	COG3385	transposase activity
GWI30_RS04475	COG5433	transposase activity
GWI30_RS04485	COG3385	transposase activity
GWI30_RS04505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWI30_RS04510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWI30_RS04535	COG2986	histidine ammonia-lyase
GWI30_RS04560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWI30_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
GWI30_RS04575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWI30_RS04585	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWI30_RS04600	COG2966	Psort location CytoplasmicMembrane, score
GWI30_RS04605	COG3610	response to peptide
GWI30_RS04615	COG4175	Glycine betaine
GWI30_RS04620	COG4176	ABC-type proline glycine betaine transport system permease component
GWI30_RS04625	COG2113	Glycine betaine
GWI30_RS04630	COG0175	sulfate reduction
GWI30_RS04635	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWI30_RS04640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWI30_RS04645	COG0384	phenazine biosynthesis protein PhzF
GWI30_RS04650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWI30_RS04665	COG5001	Diguanylate cyclase
GWI30_RS04680	COG0252	asparaginase activity
GWI30_RS04685	COG3139	Protein of unknown function (DUF1315)
GWI30_RS04705	COG0616	signal peptide processing
GWI30_RS04710	COG1902	pentaerythritol trinitrate reductase activity
GWI30_RS04710	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWI30_RS04715	COG0778	Nitroreductase
GWI30_RS04730	COG2264	protein methyltransferase activity
GWI30_RS04740	COG0583	DNA-binding transcription factor activity
GWI30_RS04745	COG1263	PTS System
GWI30_RS04745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWI30_RS04745	COG2190	(PTS) system
GWI30_RS04750	COG4145	pantothenate transmembrane transporter activity
GWI30_RS04755	COG3924	membrane
GWI30_RS04760	COG0439	Biotin carboxylase
GWI30_RS04765	COG0511	ligase activity, forming carbon-carbon bonds
GWI30_RS04770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWI30_RS04775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWI30_RS04790	COG3381	protein complex oligomerization
GWI30_RS04800	COG3005	denitrification pathway
GWI30_RS04805	COG0745	RESPONSE REGULATOR receiver
GWI30_RS04815	COG1879	ABC-type sugar transport system periplasmic component
GWI30_RS04820	COG2198	Histidine kinase
GWI30_RS04820	COG2205	protein histidine kinase activity
GWI30_RS04820	COG0784	Response regulator, receiver
GWI30_RS04830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWI30_RS04845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWI30_RS04850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWI30_RS04850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWI30_RS04865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWI30_RS04870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWI30_RS04875	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWI30_RS04880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWI30_RS04905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWI30_RS04910	COG0142	geranyltranstransferase activity
GWI30_RS04915	COG1722	exodeoxyribonuclease VII activity
GWI30_RS04920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWI30_RS04925	COG1360	Flagellar Motor Protein
GWI30_RS04930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWI30_RS04940	COG1534	Rna-binding protein
GWI30_RS04945	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GWI30_RS04950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWI30_RS04955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWI30_RS04960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWI30_RS04965	COG0149	triose-phosphate isomerase activity
GWI30_RS04970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWI30_RS04985	COG0779	Required for maturation of 30S ribosomal subunits
GWI30_RS04990	COG0195	Participates in both transcription termination and antitermination
GWI30_RS04995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWI30_RS05000	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWI30_RS05005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWI30_RS05010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GWI30_RS05015	COG1185	polyribonucleotide nucleotidyltransferase activity
GWI30_RS05020	COG2211	Major facilitator Superfamily
GWI30_RS05025	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWI30_RS05040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWI30_RS05060	COG0312	modulator of DNA gyrase
GWI30_RS05070	COG0716	FMN binding
GWI30_RS05075	COG4974	Belongs to the 'phage' integrase family
GWI30_RS05085	COG1970	mechanosensitive ion channel activity
GWI30_RS05110	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWI30_RS05135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWI30_RS05140	COG0321	lipoyl(octanoyl) transferase activity
GWI30_RS05145	COG2921	Belongs to the UPF0250 family
GWI30_RS05150	COG1686	Belongs to the peptidase S11 family
GWI30_RS05155	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWI30_RS05160	COG2951	lytic endotransglycosylase activity
GWI30_RS05165	COG0772	Belongs to the SEDS family
GWI30_RS05170	COG0768	penicillin binding
GWI30_RS05175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GWI30_RS05180	COG0799	negative regulation of ribosome biogenesis
GWI30_RS05185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWI30_RS05200	COG0495	leucyl-tRNA aminoacylation
GWI30_RS05205	COG2888	peptidyl-tyrosine sulfation
GWI30_RS05210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWI30_RS05215	COG4535	Mg2 and Co2 transporter CorC
GWI30_RS05220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWI30_RS05225	COG1702	phosphate starvation-inducible protein PhoH
GWI30_RS05230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWI30_RS05235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWI30_RS05240	COG1278	Cold shock
GWI30_RS05245	COG0583	DNA-binding transcription factor activity
GWI30_RS05255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWI30_RS05280	COG3706	GGDEF domain
GWI30_RS05290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWI30_RS05300	COG3647	Membrane
GWI30_RS05305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWI30_RS05315	COG0516	GMP reductase activity
GWI30_RS05325	COG0642	Histidine kinase
GWI30_RS05330	COG0745	RESPONSE REGULATOR receiver
GWI30_RS05340	COG0300	oxidoreductase activity
GWI30_RS05360	COG4106	trans-aconitate 2-methyltransferase activity
GWI30_RS05365	COG3214	Protein conserved in bacteria
GWI30_RS05375	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GWI30_RS05380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWI30_RS05385	COG1053	succinate dehydrogenase
GWI30_RS05395	COG0584	glycerophosphoryl diester phosphodiesterase
GWI30_RS05400	COG3264	Mechanosensitive ion channel
GWI30_RS05400	COG1511	domain protein
GWI30_RS05410	COG0739	heme binding
GWI30_RS05420	COG3121	Chaperone
GWI30_RS05425	COG3188	usher protein
GWI30_RS05430	COG3121	Chaperone
GWI30_RS05445	COG0583	DNA-binding transcription factor activity
GWI30_RS05460	COG0583	DNA-binding transcription factor activity
GWI30_RS05465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GWI30_RS05495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWI30_RS05500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWI30_RS05510	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GWI30_RS05515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWI30_RS05525	COG0180	Tryptophanyl-tRNA synthetase
GWI30_RS05540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWI30_RS05550	COG1012	belongs to the aldehyde dehydrogenase family
GWI30_RS05560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWI30_RS05585	COG0490	domain, Protein
GWI30_RS05585	COG0471	metal ion transport
GWI30_RS05630	COG0012	GTP binding
GWI30_RS05635	COG0193	aminoacyl-tRNA hydrolase activity
GWI30_RS05640	COG0737	Belongs to the 5'-nucleotidase family
GWI30_RS05645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWI30_RS05655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GWI30_RS05660	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GWI30_RS05665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWI30_RS05670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWI30_RS05675	COG2890	protein-(glutamine-N5) methyltransferase activity
GWI30_RS05685	COG2912	Transglutaminase-like superfamily
GWI30_RS05695	COG1301	dicarboxylic acid transport
GWI30_RS05705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GWI30_RS05725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWI30_RS05730	COG1115	amino acid carrier protein
GWI30_RS05750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GWI30_RS05755	COG1678	Uncharacterized ACR, COG1678
GWI30_RS05760	COG0189	ligase activity
GWI30_RS05765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWI30_RS05775	COG3091	SprT-like family
GWI30_RS05785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWI30_RS05790	COG5433	transposase activity
GWI30_RS05830	COG3385	transposase activity
GWI30_RS05850	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWI30_RS05855	COG0739	heme binding
GWI30_RS05860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWI30_RS05880	COG3366	ferrous iron transmembrane transporter activity
GWI30_RS05885	COG0700	Nucleoside recognition
GWI30_RS05890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWI30_RS05920	COG0583	DNA-binding transcription factor activity
GWI30_RS05930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWI30_RS05940	COG0583	DNA-binding transcription factor activity
GWI30_RS05945	COG1028	Short-chain dehydrogenase reductase Sdr
GWI30_RS05950	COG0616	signal peptide processing
GWI30_RS05955	COG3724	N-succinylarginine dihydrolase activity
GWI30_RS05960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWI30_RS05970	COG0840	transmembrane signaling receptor activity
GWI30_RS05980	COG2971	BadF BadG BcrA BcrD
GWI30_RS05990	COG4608	Belongs to the ABC transporter superfamily
GWI30_RS05995	COG0444	Belongs to the ABC transporter superfamily
GWI30_RS06000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWI30_RS06020	COG3064	Membrane
GWI30_RS06020	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GWI30_RS06020	COG1073	alpha beta
GWI30_RS06030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWI30_RS06050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWI30_RS06080	COG1309	transcriptional regulator
GWI30_RS06120	COG0643	Histidine kinase
GWI30_RS06120	COG2198	Histidine kinase
GWI30_RS06125	COG2201	protein-glutamate methylesterase activity
GWI30_RS06130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWI30_RS06135	COG1360	Flagellar Motor Protein
GWI30_RS06140	COG1192	Involved in chromosome partitioning
GWI30_RS06150	COG0835	chemotaxis
GWI30_RS06165	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWI30_RS06170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWI30_RS06175	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GWI30_RS06180	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GWI30_RS06185	COG1138	Cytochrome C-type biogenesis protein
GWI30_RS06190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWI30_RS06195	COG4235	cytochrome complex assembly
GWI30_RS06195	COG3088	subunit of a heme lyase
GWI30_RS06215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GWI30_RS06220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWI30_RS06220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWI30_RS06235	COG0259	pyridoxamine-phosphate oxidase activity
GWI30_RS06250	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GWI30_RS06255	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GWI30_RS06265	COG0083	homoserine kinase activity
GWI30_RS06270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWI30_RS06275	COG4319	ketosteroid isomerase
GWI30_RS06315	COG2205	protein histidine kinase activity
GWI30_RS06320	COG0745	RESPONSE REGULATOR receiver
GWI30_RS06330	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWI30_RS06350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GWI30_RS06375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWI30_RS06380	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GWI30_RS06435	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWI30_RS06440	COG1763	Mo-molybdopterin cofactor biosynthetic process
GWI30_RS06445	COG0746	molybdenum cofactor guanylyltransferase activity
GWI30_RS06450	COG0281	malic enzyme
GWI30_RS06485	COG5433	transposase activity
GWI30_RS06495	COG1129	ABC transporter
GWI30_RS06500	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWI30_RS06505	COG1472	Belongs to the glycosyl hydrolase 3 family
GWI30_RS06520	COG1196	nuclear chromosome segregation
GWI30_RS06520	COG3264	Mechanosensitive ion channel
GWI30_RS06525	COG0469	pyruvate kinase activity
GWI30_RS06530	COG2850	peptidyl-arginine hydroxylation
GWI30_RS06535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWI30_RS06540	COG2915	High frequency lysogenization protein hflD homolog
GWI30_RS06545	COG0482	sulfurtransferase activity
GWI30_RS06565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWI30_RS06575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWI30_RS06575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWI30_RS06575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWI30_RS06580	COG3385	transposase activity
GWI30_RS06600	COG5492	domain, Protein
GWI30_RS06600	COG4932	domain protein
GWI30_RS06605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWI30_RS06615	COG1482	cell wall glycoprotein biosynthetic process
GWI30_RS06620	COG2207	Transcriptional regulator
GWI30_RS06625	COG0538	isocitrate dehydrogenase activity
GWI30_RS06630	COG3048	D-serine ammonia-lyase activity
GWI30_RS06635	COG2610	gluconate transmembrane transporter activity
GWI30_RS06640	COG0583	DNA-binding transcription factor activity
GWI30_RS06645	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWI30_RS06650	COG3385	transposase activity
GWI30_RS06655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWI30_RS06660	COG2375	cellular response to nickel ion
GWI30_RS06670	COG1136	(ABC) transporter
GWI30_RS06670	COG0577	efflux transmembrane transporter activity
GWI30_RS06675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWI30_RS06685	COG1227	inorganic diphosphatase activity
GWI30_RS06690	COG0497	DNA recombination
GWI30_RS06695	COG3706	GGDEF domain
GWI30_RS06700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWI30_RS06705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWI30_RS06710	COG0443	Heat shock 70 kDa protein
GWI30_RS06715	COG0484	heat shock protein binding
GWI30_RS06745	COG1285	pathogenesis
GWI30_RS06765	COG0640	Transcriptional regulator
GWI30_RS06795	COG0095	Lipoate-protein ligase
GWI30_RS06810	COG0675	Transposase, IS605 OrfB family
GWI30_RS06830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWI30_RS06835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWI30_RS06845	COG0708	Exodeoxyribonuclease III
GWI30_RS06870	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GWI30_RS06885	COG1846	Transcriptional regulator
GWI30_RS06900	COG0675	Transposase, IS605 OrfB family
GWI30_RS06915	COG0583	DNA-binding transcription factor activity
GWI30_RS06925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWI30_RS06930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWI30_RS06935	COG1845	cytochrome c oxidase, subunit III
GWI30_RS06940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWI30_RS06945	COG0109	protoheme IX farnesyltransferase activity
GWI30_RS06950	COG2814	Major facilitator Superfamily
GWI30_RS06955	COG5507	3-demethylubiquinone-9 3-methyltransferase
GWI30_RS06990	COG3550	peptidyl-serine autophosphorylation
GWI30_RS06995	COG1396	sequence-specific DNA binding
GWI30_RS07035	COG0159	tryptophan synthase activity
GWI30_RS07040	COG0133	tryptophan synthase activity
GWI30_RS07045	COG0135	phosphoribosylanthranilate isomerase activity
GWI30_RS07045	COG0134	indole-3-glycerol-phosphate synthase activity
GWI30_RS07050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWI30_RS07055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWI30_RS07055	COG0512	Glutamine amidotransferase of anthranilate synthase
GWI30_RS07060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWI30_RS07070	COG0009	L-threonylcarbamoyladenylate synthase
GWI30_RS07080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWI30_RS07090	COG1946	Acyl-CoA thioesterase
GWI30_RS07105	COG1309	transcriptional regulator
GWI30_RS07110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWI30_RS07115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWI30_RS07120	COG1538	Outer membrane efflux protein
GWI30_RS07145	COG4584	PFAM Integrase catalytic
GWI30_RS07150	COG1484	DNA-dependent DNA replication
GWI30_RS07165	COG3657	addiction module killer protein
GWI30_RS07205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWI30_RS07215	COG1960	acyl-CoA dehydrogenase activity
GWI30_RS07220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWI30_RS07230	COG0469	pyruvate kinase activity
GWI30_RS07235	COG1737	Transcriptional regulator
GWI30_RS07255	COG0745	RESPONSE REGULATOR receiver
GWI30_RS07275	COG3039	Transposase
GWI30_RS07305	COG5433	transposase activity
GWI30_RS07330	COG5433	transposase activity
GWI30_RS07335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GWI30_RS07360	COG1216	Glycosyl transferase, family 2
GWI30_RS07375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWI30_RS07410	COG1943	Transposase
GWI30_RS07425	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWI30_RS07440	COG3132	Protein of unknown function, DUF480
GWI30_RS07480	COG1278	Cold shock
GWI30_RS07510	COG0697	spore germination
GWI30_RS07530	COG0675	Transposase, IS605 OrfB family
GWI30_RS07540	COG1187	pseudouridine synthase activity
GWI30_RS07555	COG4166	transmembrane transport
GWI30_RS07560	COG0622	Phosphoesterase
GWI30_RS07580	COG0835	chemotaxis
GWI30_RS07580	COG0784	Response regulator, receiver
GWI30_RS07585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWI30_RS07590	COG1815	bacterial-type flagellum-dependent cell motility
GWI30_RS07595	COG1558	bacterial-type flagellum-dependent cell motility
GWI30_RS07605	COG1749	Flagellar hook protein flgE
GWI30_RS07615	COG4786	Flagellar basal body rod
GWI30_RS07620	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GWI30_RS07625	COG1706	bacterial-type flagellum-dependent cell motility
GWI30_RS07630	COG3951	Flagellar rod assembly protein muramidase FlgJ
GWI30_RS07630	COG1705	Flagellar rod assembly protein muramidase FlgJ
GWI30_RS07675	COG0675	Transposase, IS605 OrfB family
GWI30_RS07685	COG0248	Ppx GppA phosphatase
GWI30_RS07690	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWI30_RS07695	COG2716	regulation of RNA biosynthetic process
GWI30_RS07705	COG2204	response regulator
GWI30_RS07710	COG3852	Histidine kinase
GWI30_RS07715	COG2204	response regulator
GWI30_RS07720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWI30_RS07725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWI30_RS07730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GWI30_RS07735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWI30_RS07760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWI30_RS07770	COG0590	tRNA wobble adenosine to inosine editing
GWI30_RS07775	COG0573	inorganic phosphate transmembrane transporter activity
GWI30_RS07780	COG0581	inorganic phosphate transmembrane transporter activity
GWI30_RS07795	COG1253	flavin adenine dinucleotide binding
GWI30_RS07810	COG0531	amino acid
GWI30_RS07815	COG3385	transposase activity
GWI30_RS07825	COG1126	abc transporter atp-binding protein
GWI30_RS07830	COG0765	amino acid transport
GWI30_RS07835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWI30_RS07850	COG0675	Transposase, IS605 OrfB family
GWI30_RS07860	COG2271	Major facilitator Superfamily
GWI30_RS07870	COG2197	response regulator
GWI30_RS07875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWI30_RS07900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GWI30_RS07905	COG0477	Major facilitator Superfamily
GWI30_RS07910	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWI30_RS07920	COG1199	ATP-dependent helicase activity
GWI30_RS07935	COG1448	Aminotransferase
GWI30_RS07945	COG0433	COG0433 Predicted ATPase
GWI30_RS07960	COG2333	competence protein COMEC
GWI30_RS07960	COG0658	competence protein
GWI30_RS07965	COG1132	(ABC) transporter
GWI30_RS07970	COG1663	tetraacyldisaccharide 4'-kinase activity
GWI30_RS07975	COG2835	tetraacyldisaccharide 4'-kinase activity
GWI30_RS07980	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWI30_RS07985	COG2197	response regulator
GWI30_RS07990	COG0322	excinuclease ABC activity
GWI30_RS08030	COG3385	transposase activity
GWI30_RS08055	COG5433	transposase activity
GWI30_RS08085	COG0625	glutathione transferase activity
GWI30_RS08090	COG2261	transglycosylase associated protein
GWI30_RS08095	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWI30_RS08105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWI30_RS08125	COG5433	transposase activity
GWI30_RS08140	COG3385	transposase activity
GWI30_RS08150	COG5433	transposase activity
GWI30_RS08175	COG2203	Gaf domain
GWI30_RS08175	COG2199	diguanylate cyclase activity
GWI30_RS08210	COG2119	membrane
GWI30_RS08215	COG0023	Translation Initiation Factor
GWI30_RS08260	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GWI30_RS08265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWI30_RS08270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GWI30_RS08275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWI30_RS08280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWI30_RS08285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWI30_RS08295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GWI30_RS08300	COG0505	Belongs to the CarA family
GWI30_RS08305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWI30_RS08310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWI30_RS08345	COG0513	Belongs to the DEAD box helicase family
GWI30_RS08355	COG4104	PAAR repeat-containing protein
GWI30_RS08370	COG0789	Transcriptional regulator
GWI30_RS08380	COG0493	'glutamate synthase
GWI30_RS08385	COG0067	glutamate synthase
GWI30_RS08385	COG0070	glutamate synthase
GWI30_RS08385	COG0069	glutamate synthase activity
GWI30_RS08390	COG1242	4 iron, 4 sulfur cluster binding
GWI30_RS08395	COG3039	Transposase
GWI30_RS08430	COG1113	amino acid transport
GWI30_RS08440	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GWI30_RS08445	COG0574	Belongs to the PEP-utilizing enzyme family
GWI30_RS08445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWI30_RS08450	COG1119	ATPase activity
GWI30_RS08465	COG1464	Belongs to the NlpA lipoprotein family
GWI30_RS08470	COG0671	phosphoesterase, PA-phosphatase related
GWI30_RS08475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWI30_RS08480	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWI30_RS08490	COG0101	tRNA pseudouridine synthase activity
GWI30_RS08495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWI30_RS08500	COG0285	dihydrofolate synthase activity
GWI30_RS08505	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GWI30_RS08510	COG2920	part of a sulfur-relay system
GWI30_RS08515	COG1289	transmembrane transporter activity
GWI30_RS08520	COG0670	Belongs to the BI1 family
GWI30_RS08545	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GWI30_RS08555	COG5433	transposase activity
GWI30_RS08565	COG2175	clavaminate synthase activity
GWI30_RS08570	COG3246	L-lysine catabolic process to acetate
GWI30_RS08575	COG2814	Major facilitator Superfamily
GWI30_RS08585	COG2855	membrane
GWI30_RS08630	COG0318	PFAM AMP-dependent synthetase and ligase
GWI30_RS08635	COG0840	transmembrane signaling receptor activity
GWI30_RS08640	COG3706	GGDEF domain
GWI30_RS08645	COG0564	pseudouridine synthase activity
GWI30_RS08660	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GWI30_RS08670	COG0625	glutathione transferase activity
GWI30_RS08690	COG0367	asparagine synthase
GWI30_RS08700	COG0647	UMP catabolic process
GWI30_RS08705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWI30_RS08750	COG1253	flavin adenine dinucleotide binding
GWI30_RS08760	COG0277	FAD linked oxidase domain protein
GWI30_RS08760	COG0247	lactate metabolic process
GWI30_RS08770	COG2050	protein possibly involved in aromatic compounds catabolism
GWI30_RS08775	COG0513	Belongs to the DEAD box helicase family
GWI30_RS08780	COG0583	DNA-binding transcription factor activity
GWI30_RS08785	COG2814	Major facilitator Superfamily
GWI30_RS08790	COG2056	Na+-H+ antiporter family
GWI30_RS08795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWI30_RS08810	COG0483	inositol monophosphate 1-phosphatase activity
GWI30_RS08825	COG0625	glutathione transferase activity
GWI30_RS08835	COG0601	transmembrane transport
GWI30_RS08840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWI30_RS08845	COG1136	(ABC) transporter
GWI30_RS08845	COG0577	efflux transmembrane transporter activity
GWI30_RS08850	COG2814	Major facilitator Superfamily
GWI30_RS08870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWI30_RS08875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWI30_RS08880	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWI30_RS08885	COG0509	glycine decarboxylation via glycine cleavage system
GWI30_RS08890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWI30_RS08890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWI30_RS08895	COG3039	Transposase
GWI30_RS08920	COG2814	Major facilitator Superfamily
GWI30_RS08925	COG3634	alkyl hydroperoxide reductase activity
GWI30_RS08930	COG0450	alkyl hydroperoxide reductase
GWI30_RS08935	COG0517	IMP dehydrogenase activity
GWI30_RS08940	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWI30_RS08945	COG0343	queuine tRNA-ribosyltransferase activity
GWI30_RS08950	COG1862	Preprotein translocase
GWI30_RS08955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWI30_RS08960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWI30_RS09005	COG1104	cysteine desulfurase activity
GWI30_RS09010	COG0822	iron-sulfur transferase activity
GWI30_RS09020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWI30_RS09025	COG0443	Heat shock 70 kDa protein
GWI30_RS09030	COG0633	Ferredoxin
GWI30_RS09040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWI30_RS09045	COG0105	UTP biosynthetic process
GWI30_RS09050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GWI30_RS09070	COG0124	histidyl-tRNA synthetase
GWI30_RS09075	COG2976	Protein conserved in bacteria
GWI30_RS09080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWI30_RS09085	COG1160	GTP binding
GWI30_RS09095	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWI30_RS09100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWI30_RS09100	COG0047	phosphoribosylformylglycinamidine synthase activity
GWI30_RS09110	COG1007	ATP synthesis coupled electron transport
GWI30_RS09115	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWI30_RS09125	COG0713	ATP synthesis coupled electron transport
GWI30_RS09130	COG0839	Belongs to the complex I subunit 6 family
GWI30_RS09135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWI30_RS09140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWI30_RS09145	COG1034	ATP synthesis coupled electron transport
GWI30_RS09160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWI30_RS09160	COG0649	NAD binding
GWI30_RS09165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWI30_RS09170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWI30_RS09175	COG1360	Flagellar Motor Protein
GWI30_RS09180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWI30_RS09200	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWI30_RS09210	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GWI30_RS09220	COG0724	RNA recognition motif
GWI30_RS09225	COG4989	oxidoreductase activity
GWI30_RS09250	COG3437	response regulator, receiver
GWI30_RS09255	COG0583	DNA-binding transcription factor activity
GWI30_RS09265	COG3300	MHYT domain
GWI30_RS09265	COG5001	Diguanylate cyclase
GWI30_RS09270	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GWI30_RS09290	COG2814	Major facilitator Superfamily
GWI30_RS09300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWI30_RS09305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GWI30_RS09310	COG0539	negative regulation of cytoplasmic translation
GWI30_RS09315	COG0776	regulation of translation
GWI30_RS09325	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GWI30_RS09345	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWI30_RS09350	COG0602	queuosine metabolic process
GWI30_RS09355	COG3530	Putative quorum-sensing-regulated virulence factor
GWI30_RS09360	COG2096	Adenosyltransferase
GWI30_RS09365	COG2916	Histone family protein nucleoid-structuring protein H-NS
GWI30_RS09370	COG1757	Na H antiporter
GWI30_RS09410	COG3550	peptidyl-serine autophosphorylation
GWI30_RS09490	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
GWI30_RS09500	COG3039	Transposase
GWI30_RS09510	COG2226	methyltransferase
GWI30_RS09530	COG3550	peptidyl-serine autophosphorylation
GWI30_RS09650	COG5433	transposase activity
GWI30_RS09655	COG5433	transposase activity
GWI30_RS09660	COG3039	Transposase
GWI30_RS09685	COG0629	single-stranded DNA binding
GWI30_RS09690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWI30_RS09695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWI30_RS09715	COG1484	DNA-dependent DNA replication
GWI30_RS09725	COG5433	transposase activity
GWI30_RS09805	COG1104	cysteine desulfurase activity
GWI30_RS09815	COG5433	transposase activity
GWI30_RS09830	COG3385	transposase activity
GWI30_RS09870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWI30_RS09875	COG0626	cystathionine gamma-synthase activity
GWI30_RS09885	COG2910	NAD(P)H-binding
GWI30_RS09890	COG0583	DNA-binding transcription factor activity
GWI30_RS09900	COG2207	Transcriptional regulator
GWI30_RS09900	COG3708	Transcriptional regulator
GWI30_RS09905	COG4774	siderophore transport
GWI30_RS09920	COG0583	DNA-binding transcription factor activity
GWI30_RS09925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWI30_RS09945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWI30_RS09950	COG3046	protein related to deoxyribodipyrimidine photolyase
GWI30_RS09965	COG3088	subunit of a heme lyase
GWI30_RS09965	COG4235	cytochrome complex assembly
GWI30_RS09970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWI30_RS09975	COG1138	Cytochrome C-type biogenesis protein
GWI30_RS09980	COG3301	Polysulphide reductase, NrfD
GWI30_RS09985	COG0437	4 iron, 4 sulfur cluster binding
GWI30_RS09990	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GWI30_RS10005	COG0247	lactate metabolic process
GWI30_RS10010	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GWI30_RS10015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWI30_RS10020	COG3012	SEC-C Motif Domain Protein
GWI30_RS10030	COG1940	carbohydrate kinase activity
GWI30_RS10030	COG1846	Transcriptional regulator
GWI30_RS10035	COG3290	protein histidine kinase activity
GWI30_RS10040	COG4565	transcriptional regulatory protein
GWI30_RS10070	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWI30_RS10075	COG0569	domain protein
GWI30_RS10075	COG2985	domain, Protein
GWI30_RS10090	COG0556	nucleotide-excision repair
GWI30_RS10100	COG0586	Pfam SNARE associated Golgi protein
GWI30_RS10110	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GWI30_RS10115	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWI30_RS10125	COG2719	SpoVR family
GWI30_RS10130	COG2718	Belongs to the UPF0229 family
GWI30_RS10135	COG2766	serine protein kinase
GWI30_RS10140	COG0514	ATP-dependent DNA helicase (RecQ)
GWI30_RS10145	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWI30_RS10150	COG0814	amino acid
GWI30_RS10155	COG5433	transposase activity
GWI30_RS10185	COG5433	transposase activity
GWI30_RS10190	COG0058	SHG alpha-glucan phosphorylase activity
GWI30_RS10205	COG0471	metal ion transport
GWI30_RS10210	COG3118	belongs to the thioredoxin family
GWI30_RS10220	COG1132	(ABC) transporter
GWI30_RS10225	COG1132	(ABC) transporter
GWI30_RS10245	COG2501	S4 domain
GWI30_RS10275	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GWI30_RS10280	COG2329	Antibiotic biosynthesis monooxygenase
GWI30_RS10285	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GWI30_RS10290	COG0673	inositol 2-dehydrogenase activity
GWI30_RS10295	COG0583	DNA-binding transcription factor activity
GWI30_RS10305	COG1560	Kdo2-lipid A biosynthetic process
GWI30_RS10310	COG1560	Kdo2-lipid A biosynthetic process
GWI30_RS10330	COG0417	DNA replication proofreading
GWI30_RS10370	COG0307	riboflavin synthase, alpha
GWI30_RS10380	COG0675	Transposase, IS605 OrfB family
GWI30_RS10390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWI30_RS10395	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GWI30_RS10400	COG0697	spore germination
GWI30_RS10405	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWI30_RS10440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWI30_RS10450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GWI30_RS10455	COG2894	cell division
GWI30_RS10460	COG0850	regulation of cytokinetic process
GWI30_RS10465	COG3100	YcgL domain-containing protein
GWI30_RS10470	COG2951	lytic endotransglycosylase activity
GWI30_RS10480	COG1760	l-serine dehydratase
GWI30_RS10485	COG1760	l-serine dehydratase
GWI30_RS10490	COG3123	guanosine phosphorylase activity
GWI30_RS10495	COG1301	dicarboxylic acid transport
GWI30_RS10510	COG2067	long-chain fatty acid transport protein
GWI30_RS10515	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GWI30_RS10520	COG2067	long-chain fatty acid transport protein
GWI30_RS10530	COG2067	long-chain fatty acid transport protein
GWI30_RS10550	COG2304	oxidoreductase activity
GWI30_RS10575	COG0714	Associated with various cellular activities
GWI30_RS10580	COG0183	Belongs to the thiolase family
GWI30_RS10585	COG1024	Enoyl-CoA hydratase
GWI30_RS10585	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWI30_RS10595	COG4681	YaeQ
GWI30_RS10630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWI30_RS10645	COG3134	Outer membrane lipoprotein
GWI30_RS10650	COG0318	PFAM AMP-dependent synthetase and ligase
GWI30_RS10655	COG2378	regulation of single-species biofilm formation
GWI30_RS10665	COG0140	phosphoribosyl-ATP diphosphatase activity
GWI30_RS10665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWI30_RS10670	COG0107	imidazoleglycerol-phosphate synthase activity
GWI30_RS10675	COG2205	protein histidine kinase activity
GWI30_RS10675	COG2198	Histidine kinase
GWI30_RS10675	COG0784	Response regulator, receiver
GWI30_RS10685	COG3437	response regulator, receiver
GWI30_RS10690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWI30_RS10695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWI30_RS10700	COG0131	Imidazoleglycerol-phosphate dehydratase
GWI30_RS10700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWI30_RS10705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWI30_RS10710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWI30_RS10715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GWI30_RS10725	COG1199	ATP-dependent helicase activity
GWI30_RS10730	COG1214	PFAM Peptidase M22, glycoprotease
GWI30_RS10740	COG0596	Alpha beta hydrolase
GWI30_RS10745	COG0318	PFAM AMP-dependent synthetase and ligase
GWI30_RS10750	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GWI30_RS10760	COG5433	transposase activity
GWI30_RS10815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWI30_RS10820	COG2832	Protein of unknown function (DUF454)
GWI30_RS10825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWI30_RS10835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GWI30_RS10840	COG1335	isochorismatase
GWI30_RS10860	COG3385	transposase activity
GWI30_RS10885	COG1643	Atp-dependent helicase
GWI30_RS10895	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWI30_RS10905	COG3437	response regulator, receiver
GWI30_RS10910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWI30_RS10915	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GWI30_RS10920	COG0709	Synthesizes selenophosphate from selenide and ATP
GWI30_RS10930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWI30_RS10935	COG0840	transmembrane signaling receptor activity
GWI30_RS10940	COG1254	Belongs to the acylphosphatase family
GWI30_RS10950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWI30_RS10950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWI30_RS10955	COG0489	protein tyrosine kinase activity
GWI30_RS10960	COG0572	uridine kinase
GWI30_RS10965	COG0717	Belongs to the dCTP deaminase family
GWI30_RS10970	COG0306	phosphate transporter
GWI30_RS10975	COG4584	PFAM Integrase catalytic
GWI30_RS10985	COG1530	ribonuclease E activity
GWI30_RS10995	COG0546	phosphoglycolate phosphatase activity
GWI30_RS11000	COG0424	maF-like protein
GWI30_RS11010	COG1399	metal-binding, possibly nucleic acid-binding protein
GWI30_RS11015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWI30_RS11020	COG0416	fatty acid biosynthetic process
GWI30_RS11025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWI30_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
GWI30_RS11040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWI30_RS11050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWI30_RS11055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWI30_RS11060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWI30_RS11065	COG0470	DNA polymerase III
GWI30_RS11070	COG0084	hydrolase, TatD family'
GWI30_RS11085	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GWI30_RS11085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWI30_RS11090	COG3008	intermembrane lipid transfer
GWI30_RS11095	COG2995	paraquat-inducible protein a
GWI30_RS11105	COG3141	response to X-ray
GWI30_RS11115	COG1067	ATP-dependent peptidase activity
GWI30_RS11120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWI30_RS11145	COG0116	Belongs to the methyltransferase superfamily
GWI30_RS11145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWI30_RS11155	COG3385	transposase activity
GWI30_RS11165	COG0167	dihydroorotate dehydrogenase activity
GWI30_RS11170	COG2902	Dehydrogenase
GWI30_RS11180	COG0308	aminopeptidase N
GWI30_RS11190	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GWI30_RS11195	COG1956	GAF domain-containing protein
GWI30_RS11205	COG3278	Belongs to the heme-copper respiratory oxidase family
GWI30_RS11220	COG2010	Cytochrome c
GWI30_RS11245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWI30_RS11250	COG0589	response to stress
GWI30_RS11255	COG0037	tRNA processing
GWI30_RS11270	COG0625	glutathione transferase activity
GWI30_RS11275	COG1869	D-ribose catabolic process
GWI30_RS11280	COG1129	ABC transporter
GWI30_RS11285	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWI30_RS11290	COG1879	ABC-type sugar transport system periplasmic component
GWI30_RS11295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWI30_RS11300	COG1609	Transcriptional regulator
GWI30_RS11305	COG3300	MHYT domain
GWI30_RS11305	COG5001	Diguanylate cyclase
GWI30_RS11315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWI30_RS11330	COG0784	Response regulator, receiver
GWI30_RS11330	COG2205	protein histidine kinase activity
GWI30_RS11335	COG0776	regulation of translation
GWI30_RS11340	COG0072	phenylalanine-tRNA ligase activity
GWI30_RS11340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWI30_RS11345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWI30_RS11350	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GWI30_RS11355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWI30_RS11360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWI30_RS11365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWI30_RS11390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWI30_RS11400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWI30_RS11410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWI30_RS11415	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GWI30_RS11420	COG3313	Fe-S protein
GWI30_RS11425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWI30_RS11425	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GWI30_RS11425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWI30_RS11430	COG1105	Belongs to the carbohydrate kinase PfkB family
GWI30_RS11435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWI30_RS11435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWI30_RS11440	COG1609	Transcriptional regulator
GWI30_RS11445	COG0814	amino acid
GWI30_RS11450	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GWI30_RS11455	COG0513	Belongs to the DEAD box helicase family
GWI30_RS11470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWI30_RS11475	COG2890	protein-(glutamine-N5) methyltransferase activity
GWI30_RS11480	COG2840	Smr protein MutS2
GWI30_RS11490	COG0406	alpha-ribazole phosphatase activity
GWI30_RS11520	COG2824	Alkylphosphonate utilization operon protein PhnA
GWI30_RS11580	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GWI30_RS11590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWI30_RS11595	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GWI30_RS11605	COG0205	6-phosphofructokinase activity
GWI30_RS11610	COG1473	amidohydrolase
GWI30_RS11615	COG1011	Hydrolase
GWI30_RS11620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWI30_RS11670	COG3593	DNA synthesis involved in DNA repair
GWI30_RS11685	COG0583	DNA-binding transcription factor activity
GWI30_RS11690	COG0730	response to heat
GWI30_RS11705	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWI30_RS11715	COG0386	Belongs to the glutathione peroxidase family
GWI30_RS11720	COG0513	Belongs to the DEAD box helicase family
GWI30_RS11725	COG0456	acetyltransferase
GWI30_RS11755	COG3706	GGDEF domain
GWI30_RS11770	COG0583	DNA-binding transcription factor activity
GWI30_RS11775	COG1028	Short-chain dehydrogenase reductase Sdr
GWI30_RS11780	COG2723	6-phospho-beta-galactosidase activity
GWI30_RS11785	COG0583	DNA-binding transcription factor activity
GWI30_RS11790	COG3706	GGDEF domain
GWI30_RS11800	COG0243	molybdopterin cofactor binding
GWI30_RS11805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWI30_RS11810	COG3039	Transposase
GWI30_RS11835	COG2003	Belongs to the UPF0758 family
GWI30_RS11860	COG3385	transposase activity
GWI30_RS11870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWI30_RS11890	COG0730	response to heat
GWI30_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
GWI30_RS11910	COG1024	Enoyl-CoA hydratase
GWI30_RS11915	COG1024	Enoyl-CoA hydratase
GWI30_RS11920	COG1960	acyl-CoA dehydrogenase activity
GWI30_RS11930	COG1960	acyl-CoA dehydrogenase activity
GWI30_RS11935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWI30_RS11940	COG1024	Enoyl-CoA hydratase
GWI30_RS11965	COG1584	GPR1 FUN34 yaaH family protein
GWI30_RS11980	COG1115	amino acid carrier protein
GWI30_RS11985	COG1024	Enoyl-CoA hydratase
GWI30_RS11995	COG2176	DNA-directed DNA polymerase activity
GWI30_RS12000	COG3162	membrane
GWI30_RS12005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWI30_RS12010	COG0488	(ABC) transporter
GWI30_RS12015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWI30_RS12020	COG0776	regulation of translation
GWI30_RS12025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWI30_RS12030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWI30_RS12035	COG0740	serine-type endopeptidase activity
GWI30_RS12040	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWI30_RS12060	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWI30_RS12065	COG1136	(ABC) transporter
GWI30_RS12070	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWI30_RS12080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWI30_RS12085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GWI30_RS12090	COG4166	transmembrane transport
GWI30_RS12095	COG0697	spore germination
GWI30_RS12105	COG2062	phosphohistidine phosphatase, SixA
GWI30_RS12150	COG0519	Catalyzes the synthesis of GMP from XMP
GWI30_RS12150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWI30_RS12155	COG0517	IMP dehydrogenase activity
GWI30_RS12155	COG0516	GMP reductase activity
GWI30_RS12165	COG0366	Alpha amylase catalytic
GWI30_RS12165	COG1874	Beta-galactosidase
GWI30_RS12175	COG1570	exodeoxyribonuclease VII activity
GWI30_RS12185	COG2885	chlorophyll binding
GWI30_RS12190	COG2199	diguanylate cyclase activity
GWI30_RS12205	COG2154	pterin-4-alpha-carbinolamine dehydratase
GWI30_RS12215	COG3768	UPF0283 membrane protein
GWI30_RS12220	COG3106	COG3106 Predicted ATPase
GWI30_RS12235	COG1842	Phage shock protein A
GWI30_RS12240	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GWI30_RS12250	COG4168	peptide transport system, permease
GWI30_RS12255	COG4171	peptide transport system, permease
GWI30_RS12265	COG4172	Belongs to the ABC transporter superfamily
GWI30_RS12275	COG1609	Transcriptional regulator
GWI30_RS12285	COG2723	6-phospho-beta-galactosidase activity
GWI30_RS12290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GWI30_RS12295	COG1286	toxin biosynthetic process
GWI30_RS12300	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWI30_RS12305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWI30_RS12310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWI30_RS12315	COG0531	amino acid
GWI30_RS12315	COG1674	ftsk spoiiie
GWI30_RS12325	COG0686	Belongs to the AlaDH PNT family
GWI30_RS12330	COG0492	ferredoxin-NADP+ reductase activity
GWI30_RS12335	COG3706	GGDEF domain
GWI30_RS12340	COG3134	Outer membrane lipoprotein
GWI30_RS12345	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GWI30_RS12350	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GWI30_RS12355	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWI30_RS12360	COG0542	response to heat
GWI30_RS12365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GWI30_RS12370	COG1278	Cold shock
GWI30_RS12375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWI30_RS12380	COG2076	Multidrug Resistance protein
GWI30_RS12395	COG1944	ATP diphosphatase activity
GWI30_RS12400	COG2116	formate transmembrane transporter activity
GWI30_RS12405	COG1882	Formate acetyltransferase
GWI30_RS12410	COG2983	Belongs to the UPF0260 family
GWI30_RS12420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWI30_RS12425	COG0045	succinate-CoA ligase (ADP-forming) activity
GWI30_RS12430	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWI30_RS12435	COG0567	Dehydrogenase, E1 component
GWI30_RS12445	COG1053	succinate dehydrogenase
GWI30_RS12450	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GWI30_RS12455	COG2009	succinate dehydrogenase
GWI30_RS12475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWI30_RS12480	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GWI30_RS12480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWI30_RS12490	COG3069	C4-dicarboxylate transmembrane transporter activity
GWI30_RS12505	COG1451	nucleotide metabolic process
GWI30_RS12520	COG0254	rRNA binding
GWI30_RS12525	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWI30_RS12535	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWI30_RS12540	COG1129	ABC transporter
GWI30_RS12545	COG1879	ABC-type sugar transport system periplasmic component
GWI30_RS12550	COG1069	ribulokinase activity
GWI30_RS12560	COG2160	L-arabinose isomerase activity
GWI30_RS12565	COG0583	DNA-binding transcription factor activity
GWI30_RS12570	COG0436	Aminotransferase
GWI30_RS12575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWI30_RS12605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWI30_RS12610	COG2925	Exonuclease
GWI30_RS12620	COG3345	alpha-galactosidase
GWI30_RS12625	COG1380	Effector of murein hydrolase LrgA
GWI30_RS12630	COG1346	cytolysis
GWI30_RS12635	COG0295	cytidine deaminase activity
GWI30_RS12640	COG1022	Amp-dependent synthetase and ligase
GWI30_RS12655	COG0861	Integral membrane protein TerC family
GWI30_RS12660	COG3385	transposase activity
GWI30_RS12665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWI30_RS12670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWI30_RS12675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GWI30_RS12695	COG0644	oxidoreductase
GWI30_RS12695	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GWI30_RS12700	COG0598	Magnesium transport protein CorA
GWI30_RS12720	COG4771	TonB-dependent receptor
GWI30_RS12725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWI30_RS12730	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWI30_RS12735	COG1120	ATPase activity
GWI30_RS12740	COG2977	Belongs to the P-Pant transferase superfamily
GWI30_RS12745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWI30_RS12750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWI30_RS12750	COG0318	PFAM AMP-dependent synthetase and ligase
GWI30_RS12750	COG1028	Short-chain dehydrogenase reductase Sdr
GWI30_RS12750	COG3321	synthase
GWI30_RS12750	COG0300	oxidoreductase activity
GWI30_RS12760	COG1028	Short-chain dehydrogenase reductase Sdr
GWI30_RS12765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWI30_RS12770	COG3433	isochorismatase activity
GWI30_RS12770	COG1535	isochorismatase
GWI30_RS12775	COG1021	2,3-dihydroxybenzoate-AMP ligase
GWI30_RS12795	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GWI30_RS12800	COG5001	Diguanylate cyclase
GWI30_RS12800	COG3300	MHYT domain
GWI30_RS12815	COG0840	transmembrane signaling receptor activity
GWI30_RS12820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWI30_RS12825	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GWI30_RS12830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GWI30_RS12835	COG0563	adenylate kinase activity
GWI30_RS12840	COG0326	Molecular chaperone. Has ATPase activity
GWI30_RS12845	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GWI30_RS12850	COG3039	Transposase
GWI30_RS12865	COG0659	secondary active sulfate transmembrane transporter activity
GWI30_RS12870	COG5433	transposase activity
GWI30_RS12885	COG2308	Evidence 4 Homologs of previously reported genes of
GWI30_RS12920	COG0672	)-iron permease
GWI30_RS12945	COG2814	Major facilitator Superfamily
GWI30_RS12965	COG1136	(ABC) transporter
GWI30_RS12980	COG3039	Transposase
GWI30_RS12995	COG1139	Iron-sulfur cluster binding protein
GWI30_RS13000	COG0247	lactate metabolic process
GWI30_RS13005	COG1620	l-lactate permease
GWI30_RS13010	COG0583	DNA-binding transcription factor activity
GWI30_RS13020	COG2315	Protein conserved in bacteria
GWI30_RS13035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWI30_RS13040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GWI30_RS13040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWI30_RS13050	COG0527	aspartate kinase activity
GWI30_RS13060	COG1368	sulfuric ester hydrolase activity
GWI30_RS13080	COG0393	Putative heavy-metal-binding
GWI30_RS13090	COG1252	NADH dehydrogenase
GWI30_RS13110	COG2354	Protein conserved in bacteria
GWI30_RS13120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWI30_RS13125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWI30_RS13130	COG0675	Transposase, IS605 OrfB family
GWI30_RS13180	COG0537	adenosine 5'-monophosphoramidase activity
GWI30_RS13195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWI30_RS13210	COG1301	dicarboxylic acid transport
GWI30_RS13220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWI30_RS13225	COG0861	Integral membrane protein TerC family
GWI30_RS13235	COG0444	Belongs to the ABC transporter superfamily
GWI30_RS13240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWI30_RS13245	COG0601	transmembrane transport
GWI30_RS13255	COG2095	MarC family integral membrane protein
GWI30_RS13260	COG1454	alcohol dehydrogenase
GWI30_RS13260	COG1012	belongs to the aldehyde dehydrogenase family
GWI30_RS13270	COG3275	phosphorelay sensor kinase activity
GWI30_RS13275	COG3279	Response regulator of the LytR AlgR family
GWI30_RS13280	COG1966	Carbon starvation protein
GWI30_RS13285	COG3264	Mechanosensitive ion channel
GWI30_RS13285	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GWI30_RS13295	COG0675	Transposase, IS605 OrfB family
GWI30_RS13310	COG1566	PFAM secretion protein HlyD family protein
GWI30_RS13315	COG1061	Type III restriction enzyme res subunit
GWI30_RS13320	COG2027	D-alanyl-D-alanine carboxypeptidase
GWI30_RS13325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GWI30_RS13335	COG0436	Aminotransferase
GWI30_RS13345	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWI30_RS13365	COG0697	spore germination
GWI30_RS13370	COG4657	Part of a membrane complex involved in electron transport
GWI30_RS13375	COG2878	Part of a membrane complex involved in electron transport
GWI30_RS13385	COG4658	electron transport chain
GWI30_RS13390	COG4659	FMN binding
GWI30_RS13400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWI30_RS13405	COG0346	lactoylglutathione lyase activity
GWI30_RS13420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWI30_RS13430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWI30_RS13460	COG5433	transposase activity
GWI30_RS13490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWI30_RS13505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWI30_RS13505	COG0301	tRNA thio-modification
GWI30_RS13515	COG4953	penicillin-binding protein 1C
GWI30_RS13520	COG2373	Large extracellular alpha-helical protein
GWI30_RS13535	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWI30_RS13545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GWI30_RS13565	COG3385	transposase activity
GWI30_RS13570	COG5433	transposase activity
GWI30_RS13630	COG0438	transferase activity, transferring glycosyl groups
GWI30_RS13630	COG1216	Glycosyl transferase, family 2
GWI30_RS13640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWI30_RS13650	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWI30_RS13660	COG5433	transposase activity
GWI30_RS13685	COG4160	amino acid transport
GWI30_RS13690	COG4215	(ABC) transporter
GWI30_RS13695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWI30_RS13705	COG2431	L-lysine efflux transmembrane transporter activity
GWI30_RS13710	COG3385	transposase activity
GWI30_RS13715	COG0675	Transposase, IS605 OrfB family
GWI30_RS13730	COG1393	Belongs to the ArsC family
GWI30_RS13740	COG4783	chaperone-mediated protein folding
GWI30_RS13760	COG0675	Transposase, IS605 OrfB family
GWI30_RS13785	COG3842	ATPase activity
GWI30_RS13795	COG1175	transmembrane transport
GWI30_RS13800	COG2182	Extracellular solute-binding protein
GWI30_RS13805	COG3081	Nucleoid-associated protein
GWI30_RS13810	COG3082	Protein of unknown function (DUF1414)
GWI30_RS13815	COG3083	sulfuric ester hydrolase activity
GWI30_RS13820	COG4206	TonB-dependent receptor
GWI30_RS13825	COG1770	oligopeptidase
GWI30_RS13845	COG4574	serine-type endopeptidase inhibitor activity
GWI30_RS13850	COG3085	chromosome segregation
GWI30_RS13860	COG1605	Chorismate mutase
GWI30_RS13860	COG0287	Prephenate dehydrogenase
GWI30_RS13865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWI30_RS13870	COG0584	glycerophosphoryl diester phosphodiesterase
GWI30_RS13880	COG1349	DNA-binding transcription factor activity
GWI30_RS13890	COG5433	transposase activity
GWI30_RS13900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWI30_RS13905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWI30_RS13910	COG0583	DNA-binding transcription factor activity
GWI30_RS13935	COG0656	L-ascorbic acid biosynthetic process
GWI30_RS13940	COG2814	Major facilitator Superfamily
GWI30_RS13950	COG1294	oxidase, subunit
GWI30_RS13960	COG3385	transposase activity
GWI30_RS13965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWI30_RS13980	COG1595	DNA-templated transcription, initiation
GWI30_RS14000	COG2979	Protein of unknown function (DUF533)
GWI30_RS14035	COG2807	transmembrane transport
GWI30_RS14040	COG1187	pseudouridine synthase activity
GWI30_RS14045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWI30_RS14070	COG5433	transposase activity
GWI30_RS14085	COG3385	transposase activity
GWI30_RS14115	COG1166	arginine decarboxylase activity
GWI30_RS14120	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWI30_RS14135	COG0675	Transposase, IS605 OrfB family
GWI30_RS14160	COG0583	DNA-binding transcription factor activity
GWI30_RS14170	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GWI30_RS14180	COG0840	transmembrane signaling receptor activity
GWI30_RS14185	COG0302	gtp cyclohydrolase
GWI30_RS14195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWI30_RS14200	COG0596	Alpha beta hydrolase
GWI30_RS14205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GWI30_RS14220	COG0314	molybdopterin synthase activity
GWI30_RS14225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GWI30_RS14230	COG0315	cyclic pyranopterin monophosphate synthase activity
GWI30_RS14235	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWI30_RS14240	COG3005	denitrification pathway
GWI30_RS14250	COG0348	domain, Protein
GWI30_RS14255	COG0437	4 iron, 4 sulfur cluster binding
GWI30_RS14260	COG0243	molybdopterin cofactor binding
GWI30_RS14270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWI30_RS14275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWI30_RS14280	COG3850	Histidine kinase
GWI30_RS14285	COG2197	response regulator
GWI30_RS14310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GWI30_RS14320	COG0121	glutamine amidotransferase
GWI30_RS14325	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWI30_RS14330	COG1960	acyl-CoA dehydrogenase activity
GWI30_RS14335	COG3437	response regulator, receiver
GWI30_RS14335	COG0784	Response regulator, receiver
GWI30_RS14345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWI30_RS14350	COG4974	Belongs to the 'phage' integrase family
GWI30_RS14380	COG0328	RNA-DNA hybrid ribonuclease activity
GWI30_RS14385	COG2226	methyltransferase
GWI30_RS14390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWI30_RS14395	COG0741	lytic transglycosylase activity
GWI30_RS14395	COG1388	LysM domain
GWI30_RS14410	COG1607	acyl-coa hydrolase
GWI30_RS14425	COG0741	lytic transglycosylase activity
GWI30_RS14435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GWI30_RS14460	COG0729	surface antigen
GWI30_RS14470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWI30_RS14480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWI30_RS14490	COG4134	Bacterial extracellular solute-binding protein
GWI30_RS14500	COG4136	ATPase activity
GWI30_RS14505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWI30_RS14510	COG2951	lytic endotransglycosylase activity
GWI30_RS14515	COG1846	Transcriptional regulator
GWI30_RS14525	COG0033	Phosphoglucomutase
GWI30_RS14530	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GWI30_RS14535	COG0596	Alpha beta hydrolase
GWI30_RS14550	COG0716	FMN binding
GWI30_RS14560	COG0735	belongs to the Fur family
GWI30_RS14565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWI30_RS14575	COG1263	PTS System
GWI30_RS14575	COG2190	(PTS) system
GWI30_RS14575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWI30_RS14580	COG0363	glucosamine-6-phosphate deaminase activity
GWI30_RS14585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWI30_RS14590	COG1846	Transcriptional regulator
GWI30_RS14590	COG1940	carbohydrate kinase activity
GWI30_RS14600	COG0217	transcriptional regulatory protein
GWI30_RS14605	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWI30_RS14615	COG1801	Protein of unknown function DUF72
GWI30_RS14620	COG4106	trans-aconitate 2-methyltransferase activity
GWI30_RS14625	COG0500	methyltransferase
GWI30_RS14645	COG0583	DNA-binding transcription factor activity
GWI30_RS14650	COG0791	NLP P60 protein
GWI30_RS14665	COG1309	transcriptional regulator
GWI30_RS14700	COG0534	Mate efflux family protein
GWI30_RS14710	COG2841	Protein conserved in bacteria
GWI30_RS14715	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWI30_RS14715	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWI30_RS14715	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWI30_RS14715	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWI30_RS14725	COG0633	Ferredoxin
GWI30_RS14725	COG0633	Ferredoxin
GWI30_RS14725	COG3217	Mosc domain protein beta barrel domain protein
GWI30_RS14725	COG3217	Mosc domain protein beta barrel domain protein
GWI30_RS14730	COG0501	Belongs to the peptidase M48B family
GWI30_RS14735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GWI30_RS14740	COG1073	alpha beta
GWI30_RS14740	COG2226	methyltransferase
GWI30_RS14745	COG0156	8-amino-7-oxononanoate synthase activity
GWI30_RS14750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWI30_RS14770	COG0017	Asparaginyl-tRNA synthetase
GWI30_RS14775	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GWI30_RS14790	COG1393	Belongs to the ArsC family
GWI30_RS14795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWI30_RS14800	COG1876	peptidase activity
GWI30_RS14805	COG3263	regulation of cellular component size
GWI30_RS14820	COG1280	lysine exporter protein (LysE YggA)
GWI30_RS14850	COG0564	pseudouridine synthase activity
GWI30_RS14865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWI30_RS14890	COG2867	negative regulation of translational initiation
GWI30_RS14895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWI30_RS14905	COG0582	viral genome integration into host DNA
GWI30_RS14960	COG3153	acetyltransferase
GWI30_RS14995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWI30_RS15005	COG0745	RESPONSE REGULATOR receiver
GWI30_RS15020	COG4988	ABC transporter
GWI30_RS15025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GWI30_RS15045	COG1720	tRNA m6t6A37 methyltransferase activity
GWI30_RS15060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWI30_RS15065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWI30_RS15070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWI30_RS15080	COG2190	(PTS) system
GWI30_RS15085	COG3038	cytochrome b561
GWI30_RS15100	COG0420	3'-5' exonuclease activity
GWI30_RS15105	COG0456	acetyltransferase
GWI30_RS15110	COG2974	May be involved in recombination
GWI30_RS15125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWI30_RS15130	COG1396	sequence-specific DNA binding
GWI30_RS15130	COG1917	Cupin 2, conserved barrel domain protein
GWI30_RS15145	COG0531	amino acid
GWI30_RS15150	COG0531	amino acid
GWI30_RS15160	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWI30_RS15170	COG3384	dioxygenase
GWI30_RS15175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWI30_RS15175	COG2205	protein histidine kinase activity
GWI30_RS15185	COG5433	transposase activity
GWI30_RS15255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWI30_RS15265	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GWI30_RS15280	COG4263	nitrous-oxide reductase activity
GWI30_RS15285	COG0348	domain, Protein
GWI30_RS15285	COG3901	Regulator of nitric oxide reductase transcription
GWI30_RS15305	COG1388	LysM domain
GWI30_RS15305	COG1376	ErfK ybiS ycfS ynhG family protein
GWI30_RS15320	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GWI30_RS15325	COG0791	NLP P60 protein
GWI30_RS15335	COG3118	belongs to the thioredoxin family
GWI30_RS15345	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWI30_RS15350	COG0788	formyltetrahydrofolate deformylase activity
GWI30_RS15375	COG1196	nuclear chromosome segregation
GWI30_RS15375	COG0741	lytic transglycosylase activity
GWI30_RS15375	COG0739	heme binding
GWI30_RS15380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWI30_RS15385	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWI30_RS15390	COG0673	inositol 2-dehydrogenase activity
GWI30_RS15410	COG1032	radical SAM domain protein
GWI30_RS15415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWI30_RS15425	COG3706	GGDEF domain
GWI30_RS15430	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWI30_RS15435	COG0733	neurotransmitter:sodium symporter activity
GWI30_RS15455	COG3385	transposase activity
GWI30_RS15470	COG3328	transposase activity
GWI30_RS15480	COG0281	malic enzyme
GWI30_RS15490	COG0534	Mate efflux family protein
GWI30_RS15500	COG0745	RESPONSE REGULATOR receiver
GWI30_RS15500	COG3706	GGDEF domain
GWI30_RS15505	COG2233	PERMEase
GWI30_RS15510	COG0095	Lipoate-protein ligase
GWI30_RS15515	COG1115	amino acid carrier protein
GWI30_RS15520	COG0019	diaminopimelate decarboxylase activity
GWI30_RS15530	COG0678	peroxiredoxin activity
GWI30_RS15535	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GWI30_RS15545	COG1126	abc transporter atp-binding protein
GWI30_RS15550	COG0765	amino acid transport
GWI30_RS15555	COG4597	amino acid ABC transporter
GWI30_RS15560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWI30_RS15575	COG1131	(ABC) transporter
GWI30_RS15580	COG0545	Peptidyl-prolyl cis-trans isomerase
GWI30_RS15595	COG3142	Participates in the control of copper homeostasis
GWI30_RS15600	COG1940	carbohydrate kinase activity
GWI30_RS15610	COG4783	chaperone-mediated protein folding
GWI30_RS15620	COG5002	protein histidine kinase activity
GWI30_RS15625	COG0745	RESPONSE REGULATOR receiver
GWI30_RS15630	COG0346	lactoylglutathione lyase activity
GWI30_RS15635	COG3706	GGDEF domain
GWI30_RS15640	COG3284	Transcriptional regulator
GWI30_RS15645	COG1012	belongs to the aldehyde dehydrogenase family
GWI30_RS15655	COG0697	spore germination
GWI30_RS15665	COG3290	protein histidine kinase activity
GWI30_RS15670	COG0281	malic enzyme
GWI30_RS15685	COG1566	PFAM secretion protein HlyD family protein
GWI30_RS15715	COG0602	queuosine metabolic process
GWI30_RS15720	COG1328	CTP reductase activity
GWI30_RS15730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWI30_RS15735	COG3115	cell septum assembly
GWI30_RS15740	COG1196	nuclear chromosome segregation
GWI30_RS15750	COG2860	membrane
GWI30_RS15760	COG3108	Peptidase M15
GWI30_RS15765	COG2989	Protein conserved in bacteria
GWI30_RS15780	COG0463	Glycosyl transferase, family 2
GWI30_RS15800	COG0366	Alpha amylase catalytic
GWI30_RS15835	COG3706	GGDEF domain
GWI30_RS15840	COG0037	tRNA processing
GWI30_RS15845	COG3590	peptidase
GWI30_RS15870	COG0531	amino acid
GWI30_RS15875	COG0814	amino acid
GWI30_RS15880	COG0583	DNA-binding transcription factor activity
GWI30_RS15890	COG0825	malonyl-CoA metabolic process
GWI30_RS15900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWI30_RS15905	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWI30_RS15910	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWI30_RS15915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWI30_RS15920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWI30_RS15935	COG0750	zinc metalloprotease
GWI30_RS15940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWI30_RS15945	COG0575	Belongs to the CDS family
GWI30_RS15955	COG0233	cytoplasmic translational termination
GWI30_RS15960	COG0528	UMP kinase activity
GWI30_RS15965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWI30_RS15970	COG0052	Belongs to the universal ribosomal protein uS2 family
GWI30_RS15975	COG0024	Methionine aminopeptidase
GWI30_RS15980	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GWI30_RS15985	COG2171	N-acyltransferase activity
GWI30_RS15995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWI30_RS15995	COG1263	PTS System
GWI30_RS16005	COG4580	involved in the transport of maltose and maltodextrins
GWI30_RS16010	COG5433	transposase activity
GWI30_RS16020	COG0564	pseudouridine synthase activity
GWI30_RS16025	COG3098	single-species biofilm formation
GWI30_RS16050	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GWI30_RS16060	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWI30_RS16060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GWI30_RS16070	COG3706	GGDEF domain
GWI30_RS16075	COG1611	Belongs to the LOG family
GWI30_RS16080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWI30_RS16085	COG0473	3-isopropylmalate dehydrogenase activity
GWI30_RS16095	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GWI30_RS16100	COG2363	Small membrane protein
GWI30_RS16110	COG0583	DNA-binding transcription factor activity
GWI30_RS16120	COG5433	transposase activity
GWI30_RS16130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWI30_RS16145	COG1477	protein flavinylation
GWI30_RS16150	COG2871	sodium ion transport
GWI30_RS16155	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWI30_RS16160	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWI30_RS16165	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWI30_RS16170	COG1805	sodium ion transport
GWI30_RS16175	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GWI30_RS16180	COG0271	Belongs to the BolA IbaG family
GWI30_RS16185	COG2813	Specifically methylates the guanine in position
GWI30_RS16195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWI30_RS16205	COG2211	Major facilitator Superfamily
GWI30_RS16210	COG3248	Nucleoside-binding outer membrane protein
GWI30_RS16215	COG1666	GTP binding
GWI30_RS16235	COG1484	DNA-dependent DNA replication
GWI30_RS16240	COG4584	PFAM Integrase catalytic
GWI30_RS16295	COG3501	Rhs element vgr protein
GWI30_RS16305	COG2771	luxR family
GWI30_RS16310	COG0659	secondary active sulfate transmembrane transporter activity
GWI30_RS16335	COG1393	Belongs to the ArsC family
GWI30_RS16340	COG0798	PFAM Bile acid sodium symporter
GWI30_RS16375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWI30_RS16380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWI30_RS16385	COG1151	hydroxylamine reductase activity
GWI30_RS16390	COG0783	Belongs to the Dps family
GWI30_RS16415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWI30_RS16430	COG0300	oxidoreductase activity
GWI30_RS16440	COG0415	Belongs to the DNA photolyase family
GWI30_RS16445	COG0789	Transcriptional regulator
GWI30_RS16450	COG3272	Protein of unknown function (DUF1722)
GWI30_RS16475	COG1605	Chorismate mutase
GWI30_RS16475	COG0077	Prephenate dehydratase
GWI30_RS16500	COG4580	involved in the transport of maltose and maltodextrins
GWI30_RS16520	COG4580	involved in the transport of maltose and maltodextrins
GWI30_RS16525	COG3940	Belongs to the glycosyl hydrolase 43 family
GWI30_RS16540	COG1175	transmembrane transport
GWI30_RS16560	COG1609	Transcriptional regulator
GWI30_RS16575	COG2133	pyrroloquinoline quinone binding
GWI30_RS16585	COG1349	DNA-binding transcription factor activity
GWI30_RS16590	COG2084	Dehydrogenase
GWI30_RS16595	COG3395	kinase activity
GWI30_RS16600	COG0235	Class ii aldolase
GWI30_RS16605	COG3622	Belongs to the hyi family
GWI30_RS16610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWI30_RS16615	COG2610	gluconate transmembrane transporter activity
GWI30_RS16635	COG0300	oxidoreductase activity
GWI30_RS16660	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GWI30_RS16680	COG3813	Protein conserved in bacteria
GWI30_RS16690	COG0826	peptidase U32
GWI30_RS16700	COG1280	lysine exporter protein (LysE YggA)
GWI30_RS16735	COG2203	Gaf domain
GWI30_RS16735	COG2199	diguanylate cyclase activity
GWI30_RS16735	COG2200	EAL domain
GWI30_RS16775	COG0114	fumarate hydratase activity
GWI30_RS16790	COG5433	transposase activity
GWI30_RS16805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWI30_RS16810	COG0305	Participates in initiation and elongation during chromosome replication
GWI30_RS16855	COG0545	Peptidyl-prolyl cis-trans isomerase
GWI30_RS16865	COG2900	Belongs to the SlyX family
GWI30_RS16870	COG1047	Peptidyl-prolyl cis-trans
GWI30_RS16875	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GWI30_RS16885	COG0784	Response regulator, receiver
GWI30_RS16885	COG0835	chemotaxis
GWI30_RS16890	COG0429	hydrolase of the alpha beta-hydrolase fold
GWI30_RS16900	COG3089	Belongs to the UPF0270 family
GWI30_RS16905	COG3954	Phosphoribulokinase
GWI30_RS16920	COG1765	OsmC-like protein
GWI30_RS16925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWI30_RS16955	COG2205	protein histidine kinase activity
GWI30_RS16960	COG2814	Major facilitator Superfamily
GWI30_RS16995	COG0748	coenzyme F420 binding
GWI30_RS17000	COG3721	Heme iron utilization protein
GWI30_RS17010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWI30_RS17035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GWI30_RS17045	COG0463	Glycosyl transferase, family 2
GWI30_RS17050	COG0741	lytic transglycosylase activity
GWI30_RS17055	COG0488	(ABC) transporter
GWI30_RS17065	COG2252	PERMEase
GWI30_RS17070	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GWI30_RS17075	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWI30_RS17080	COG3178	'Phosphotransferase
GWI30_RS17085	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GWI30_RS17095	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GWI30_RS17100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWI30_RS17110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWI30_RS17130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWI30_RS17135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GWI30_RS17145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWI30_RS17150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWI30_RS17155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWI30_RS17160	COG0142	geranyltranstransferase activity
GWI30_RS17165	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GWI30_RS17170	COG0330	HflC and HflK could
GWI30_RS17175	COG0330	HflC and HflK could
GWI30_RS17180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWI30_RS17185	COG1923	regulation of RNA biosynthetic process
GWI30_RS17190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWI30_RS17195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWI30_RS17205	COG0802	atpase or kinase
GWI30_RS17210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWI30_RS17210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWI30_RS17230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWI30_RS17235	COG2011	ABC-type metal ion transport system permease component
GWI30_RS17240	COG1464	Belongs to the NlpA lipoprotein family
GWI30_RS17255	COG0840	transmembrane signaling receptor activity
GWI30_RS17280	COG5433	transposase activity
GWI30_RS17290	COG3039	Transposase
GWI30_RS17295	COG5433	transposase activity
GWI30_RS17310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWI30_RS17315	COG1376	ErfK ybiS ycfS ynhG family protein
GWI30_RS17320	COG0668	transmembrane transport
GWI30_RS17330	COG2731	YhcH YjgK YiaL family protein
GWI30_RS17345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWI30_RS17360	COG5433	transposase activity
GWI30_RS17370	COG0477	Major facilitator Superfamily
GWI30_RS17390	COG0569	domain protein
GWI30_RS17390	COG2985	domain, Protein
GWI30_RS17395	COG1272	protein, Hemolysin III
GWI30_RS17400	COG0076	glutamate decarboxylase activity
GWI30_RS17405	COG2917	probably involved in intracellular septation
GWI30_RS17410	COG2350	Protein conserved in bacteria
GWI30_RS17420	COG1555	photosystem II stabilization
GWI30_RS17425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWI30_RS17430	COG3104	oligopeptide transport
GWI30_RS17435	COG0745	RESPONSE REGULATOR receiver
GWI30_RS17465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWI30_RS17475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWI30_RS17480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GWI30_RS17520	COG0316	Belongs to the HesB IscA family
GWI30_RS17535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWI30_RS17550	COG0671	phosphoesterase, PA-phosphatase related
GWI30_RS17560	COG0583	DNA-binding transcription factor activity
GWI30_RS17565	COG2076	Multidrug Resistance protein
GWI30_RS17575	COG0346	lactoylglutathione lyase activity
GWI30_RS17580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWI30_RS17585	COG1643	Atp-dependent helicase
GWI30_RS17590	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GWI30_RS17595	COG1489	DNA binding
GWI30_RS17600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWI30_RS17605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWI30_RS17610	COG0617	tRNA 3'-terminal CCA addition
GWI30_RS17620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWI30_RS17625	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GWI30_RS17635	COG0842	Transport permease protein
GWI30_RS17640	COG1131	(ABC) transporter
GWI30_RS17655	COG3385	transposase activity
GWI30_RS17665	COG0163	prenyltransferase activity
GWI30_RS17670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWI30_RS17675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GWI30_RS17690	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GWI30_RS17725	COG0840	transmembrane signaling receptor activity
GWI30_RS17735	COG3385	transposase activity
GWI30_RS17745	COG0529	Catalyzes the synthesis of activated sulfate
GWI30_RS17750	COG0471	metal ion transport
GWI30_RS17750	COG3273	potassium ion transport
GWI30_RS17755	COG2895	sulfate adenylyltransferase (ATP) activity
GWI30_RS17770	COG1648	precorrin-2 dehydrogenase activity
GWI30_RS17770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWI30_RS17775	COG0330	HflC and HflK could
GWI30_RS17780	COG1585	Membrane protein implicated in regulation of membrane protease activity
GWI30_RS17790	COG0673	inositol 2-dehydrogenase activity
GWI30_RS17795	COG2814	Major facilitator Superfamily
GWI30_RS17800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWI30_RS17805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWI30_RS17810	COG3036	rescue of stalled ribosome
GWI30_RS17830	COG0138	bifunctional purine biosynthesis protein purh
GWI30_RS17835	COG0151	Belongs to the GarS family
GWI30_RS17860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWI30_RS17865	COG0358	DNA primase activity
GWI30_RS17870	COG1610	YqeY-like protein
GWI30_RS17875	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWI30_RS17880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWI30_RS17885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWI30_RS17895	COG3039	Transposase
GWI30_RS17900	COG1388	LysM domain
GWI30_RS17900	COG4942	peptidase
GWI30_RS17905	COG1238	metal cluster binding
GWI30_RS17910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWI30_RS17915	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWI30_RS17920	COG0585	pseudouridine synthase activity
GWI30_RS17930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWI30_RS17935	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWI30_RS17940	COG0148	phosphopyruvate hydratase activity
GWI30_RS17945	COG0504	CTP synthase activity
GWI30_RS17950	COG3956	TIGRFAM MazG family protein
GWI30_RS17955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWI30_RS17960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWI30_RS17970	COG4807	Protein conserved in bacteria
GWI30_RS17975	COG3023	N-Acetylmuramoyl-L-alanine amidase
GWI30_RS17980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GWI30_RS17985	COG1381	Involved in DNA repair and RecF pathway recombination
GWI30_RS17995	COG0571	ribonuclease III activity
GWI30_RS18000	COG0681	Belongs to the peptidase S26 family
GWI30_RS18005	COG0481	GTPase activity
GWI30_RS18025	COG1595	DNA-templated transcription, initiation
GWI30_RS18030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GWI30_RS18040	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GWI30_RS18080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWI30_RS18085	COG0191	fructose-bisphosphate aldolase activity
GWI30_RS18090	COG0126	phosphoglycerate kinase activity
GWI30_RS18095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWI30_RS18100	COG1940	carbohydrate kinase activity
GWI30_RS18105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GWI30_RS18115	COG4991	sh3 domain protein
GWI30_RS18120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWI30_RS18135	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GWI30_RS18140	COG1028	Short-chain dehydrogenase reductase Sdr
GWI30_RS18150	COG1505	serine-type exopeptidase activity
GWI30_RS18155	COG3174	membrane
GWI30_RS18160	COG0110	maltose O-acetyltransferase activity
GWI30_RS18185	COG3039	Transposase
GWI30_RS18190	COG0165	Argininosuccinate lyase
GWI30_RS18195	COG0137	argininosuccinate synthase activity
GWI30_RS18205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWI30_RS18210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWI30_RS18220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GWI30_RS18225	COG5002	protein histidine kinase activity
GWI30_RS18225	COG3447	MASE1 domain protein
GWI30_RS18225	COG5001	Diguanylate cyclase
GWI30_RS18270	COG0583	DNA-binding transcription factor activity
GWI30_RS18275	COG1380	Effector of murein hydrolase LrgA
GWI30_RS18280	COG1346	cytolysis
GWI30_RS18285	COG0460	homoserine dehydrogenase
GWI30_RS18285	COG0527	aspartate kinase activity
GWI30_RS18290	COG0626	cystathionine gamma-synthase activity
GWI30_RS18305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWI30_RS18310	COG0814	amino acid
GWI30_RS18315	COG1218	3'(2'),5'-bisphosphate nucleotidase
GWI30_RS18320	COG0494	nUDIX hydrolase
GWI30_RS18325	COG1011	Hydrolase
GWI30_RS18335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWI30_RS18350	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GWI30_RS18360	COG3156	type II secretion system protein K
GWI30_RS18370	COG4795	General secretion pathway protein
GWI30_RS18375	COG2165	general secretion pathway protein
GWI30_RS18385	COG2165	general secretion pathway protein
GWI30_RS18390	COG1459	type II secretion system
GWI30_RS18395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWI30_RS18405	COG3031	protein transport across the cell outer membrane
GWI30_RS18415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWI30_RS18420	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GWI30_RS18440	COG3133	Outer membrane lipoprotein
GWI30_RS18450	COG1392	Phosphate transport regulator
GWI30_RS18455	COG0306	phosphate transporter
GWI30_RS18460	COG0617	tRNA 3'-terminal CCA addition
GWI30_RS18465	COG3267	Type II secretory pathway component ExeA
GWI30_RS18465	COG3409	Peptidoglycan-binding domain 1 protein
GWI30_RS18475	COG1194	a g-specific adenine glycosylase
GWI30_RS18480	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GWI30_RS18495	COG3240	lipase activity
GWI30_RS18505	COG3009	Protein conserved in bacteria
GWI30_RS18510	COG3008	intermembrane lipid transfer
GWI30_RS18510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWI30_RS18515	COG2995	paraquat-inducible protein a
GWI30_RS18525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWI30_RS18530	COG2203	Gaf domain
GWI30_RS18530	COG3706	GGDEF domain
GWI30_RS18530	COG4251	negative regulation of phosphorylation
GWI30_RS18530	COG5001	Diguanylate cyclase
GWI30_RS18535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWI30_RS18540	COG2813	Specifically methylates the guanine in position
GWI30_RS18545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GWI30_RS18550	COG0297	glycogen (starch) synthase activity
GWI30_RS18590	COG1757	Na H antiporter
GWI30_RS18595	COG0583	DNA-binding transcription factor activity
GWI30_RS18600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GWI30_RS18605	COG3842	ATPase activity
GWI30_RS18610	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWI30_RS18615	COG1177	transmembrane transport
GWI30_RS18620	COG1012	belongs to the aldehyde dehydrogenase family
GWI30_RS18625	COG0109	protoheme IX farnesyltransferase activity
GWI30_RS18630	COG1612	heme a metabolic process
GWI30_RS18655	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GWI30_RS18660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWI30_RS18665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWI30_RS18670	COG1444	tRNA N-acetyltransferase activity
GWI30_RS18690	COG1803	Methylglyoxal synthase
GWI30_RS18705	COG0252	asparaginase activity
GWI30_RS18715	COG1609	Transcriptional regulator
GWI30_RS18725	COG1940	carbohydrate kinase activity
GWI30_RS18730	COG1447	Phosphotransferase system cellobiose-specific component IIA
GWI30_RS18735	COG2723	6-phospho-beta-galactosidase activity
GWI30_RS18740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GWI30_RS18740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GWI30_RS18745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GWI30_RS18750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GWI30_RS18765	COG1263	PTS System
GWI30_RS18765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GWI30_RS18770	COG0366	Alpha amylase catalytic
GWI30_RS18775	COG0110	maltose O-acetyltransferase activity
GWI30_RS18780	COG1522	sequence-specific DNA binding
GWI30_RS18795	COG3385	transposase activity
GWI30_RS18830	COG1484	DNA-dependent DNA replication
GWI30_RS18835	COG4584	PFAM Integrase catalytic
GWI30_RS18865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWI30_RS18870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GWI30_RS18885	COG0477	Major facilitator Superfamily
GWI30_RS18890	COG0523	cobalamin synthesis protein
GWI30_RS18900	COG1280	lysine exporter protein (LysE YggA)
GWI30_RS18910	COG2200	EAL domain
GWI30_RS18915	COG1049	propionate catabolic process, 2-methylcitrate cycle
GWI30_RS18920	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWI30_RS18925	COG0840	transmembrane signaling receptor activity
GWI30_RS18940	COG3706	GGDEF domain
GWI30_RS18945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWI30_RS18950	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWI30_RS18955	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GWI30_RS18960	COG2186	Transcriptional regulator
GWI30_RS18985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWI30_RS18990	COG1459	type II secretion system
GWI30_RS18995	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GWI30_RS19005	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GWI30_RS19010	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GWI30_RS19020	COG0653	protein targeting
GWI30_RS19030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GWI30_RS19035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWI30_RS19040	COG0849	cell division
GWI30_RS19045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWI30_RS19050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWI30_RS19055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWI30_RS19060	COG0772	Belongs to the SEDS family
GWI30_RS19065	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWI30_RS19070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWI30_RS19075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWI30_RS19080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWI30_RS19085	COG0768	penicillin binding
GWI30_RS19090	COG3116	cell division
GWI30_RS19095	COG0275	rRNA processing
GWI30_RS19100	COG2001	Belongs to the MraZ family
GWI30_RS19110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWI30_RS19115	COG3107	peptidoglycan biosynthetic process
GWI30_RS19120	COG0792	nuclease activity
GWI30_RS19125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GWI30_RS19130	COG2823	Periplasmic or secreted lipoprotein
GWI30_RS19135	COG2969	positive regulation of protein catabolic process
GWI30_RS19140	COG0625	glutathione transferase activity
GWI30_RS19145	COG2857	Cytochrome c1
GWI30_RS19150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWI30_RS19155	COG0723	plastoquinol--plastocyanin reductase activity
GWI30_RS19160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWI30_RS19165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWI30_RS19170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GWI30_RS19180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWI30_RS19185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWI30_RS19195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWI30_RS19200	COG1660	Displays ATPase and GTPase activities
GWI30_RS19205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWI30_RS19220	COG1137	ATPase activity
GWI30_RS19225	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GWI30_RS19230	COG3117	lipopolysaccharide transmembrane transporter activity
GWI30_RS19235	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GWI30_RS19240	COG0517	IMP dehydrogenase activity
GWI30_RS19240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GWI30_RS19245	COG1127	ABC transporter
GWI30_RS19250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWI30_RS19255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWI30_RS19260	COG2854	intermembrane phospholipid transfer
GWI30_RS19270	COG5007	Belongs to the BolA IbaG family
GWI30_RS19275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWI30_RS19280	COG0312	modulator of DNA gyrase
GWI30_RS19285	COG3028	Belongs to the UPF0307 family
GWI30_RS19305	COG2926	Belongs to the UPF0265 family
GWI30_RS19335	COG1396	sequence-specific DNA binding
GWI30_RS19340	COG3135	benzoate transporter
GWI30_RS19350	COG1522	sequence-specific DNA binding
GWI30_RS19360	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GWI30_RS19370	COG1058	Belongs to the CinA family
GWI30_RS19370	COG1546	Belongs to the CinA family
GWI30_RS19375	COG1988	membrane-bound metal-dependent
GWI30_RS19385	COG0561	phosphatase activity
GWI30_RS19390	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GWI30_RS19400	COG1011	Hydrolase
GWI30_RS19415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWI30_RS19420	COG0019	diaminopimelate decarboxylase activity
GWI30_RS19430	COG1965	Belongs to the frataxin family
GWI30_RS19435	COG0400	carboxylic ester hydrolase activity
GWI30_RS19440	COG3072	Adenylate cyclase
GWI30_RS19445	COG0181	hydroxymethylbilane synthase activity
GWI30_RS19455	COG2959	enzyme of heme biosynthesis
GWI30_RS19460	COG3071	HemY protein
GWI30_RS19470	COG1494	fructose-1,6-bisphosphatase
GWI30_RS19480	COG1247	-acetyltransferase
GWI30_RS19500	COG1733	regulation of RNA biosynthetic process
GWI30_RS19520	COG3932	Exopolysaccharide synthesis, ExoD
GWI30_RS19525	COG3706	GGDEF domain
GWI30_RS19550	COG3039	Transposase
GWI30_RS19555	COG3385	transposase activity
GWI30_RS19560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWI30_RS19565	COG2022	thiamine diphosphate biosynthetic process
GWI30_RS19575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWI30_RS19580	COG0352	thiamine-phosphate diphosphorylase activity
GWI30_RS19585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GWI30_RS19600	COG0745	RESPONSE REGULATOR receiver
GWI30_RS19610	COG0189	ligase activity
GWI30_RS19635	COG2321	neutral zinc metallopeptidase
GWI30_RS19645	COG0477	Major facilitator Superfamily
GWI30_RS19660	COG0312	modulator of DNA gyrase
GWI30_RS19665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWI30_RS19670	COG3164	Protein of unknown function
GWI30_RS19675	COG1530	ribonuclease E activity
GWI30_RS19680	COG0424	maF-like protein
GWI30_RS19685	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GWI30_RS19690	COG1792	Involved in formation and maintenance of cell shape
GWI30_RS19695	COG1077	Cell shape determining protein MreB Mrl
GWI30_RS19705	COG3385	transposase activity
GWI30_RS19755	COG1459	type II secretion system
GWI30_RS19760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWI30_RS19805	COG2199	diguanylate cyclase activity
GWI30_RS19805	COG2200	EAL domain
GWI30_RS19810	COG3385	transposase activity
GWI30_RS19815	COG2200	EAL domain
GWI30_RS19820	COG0387	Pfam Sodium calcium exchanger
GWI30_RS19825	COG2986	histidine ammonia-lyase
GWI30_RS19830	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GWI30_RS19835	COG0010	Belongs to the arginase family
GWI30_RS19840	COG1228	amidohydrolase
GWI30_RS19845	COG2188	Transcriptional regulator
GWI30_RS19850	COG0288	reversible hydration of carbon dioxide
GWI30_RS19860	COG2177	Part of the ABC transporter FtsEX involved in
GWI30_RS19865	COG2884	Cell division ATP-binding protein ftsE
GWI30_RS19870	COG0552	protein localization to endoplasmic reticulum
GWI30_RS19875	COG0742	ribosomal rna small subunit methyltransferase
GWI30_RS19900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWI30_RS19905	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GWI30_RS19915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWI30_RS19925	COG2095	MarC family integral membrane protein
GWI30_RS19935	COG1301	dicarboxylic acid transport
GWI30_RS19960	COG3385	transposase activity
GWI30_RS19965	COG3714	YhhN family
GWI30_RS19980	COG1770	oligopeptidase
GWI30_RS19995	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWI30_RS20050	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWI30_RS20055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWI30_RS20060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWI30_RS20065	COG0049	tRNA binding
GWI30_RS20070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GWI30_RS20075	COG2168	tRNA wobble position uridine thiolation
GWI30_RS20095	COG2964	Protein conserved in bacteria
GWI30_RS20100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWI30_RS20105	COG0085	RNA polymerase activity
GWI30_RS20110	COG0222	ribosome binding
GWI30_RS20115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWI30_RS20120	COG0081	regulation of translation
GWI30_RS20125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWI30_RS20130	COG0250	Participates in transcription elongation, termination and antitermination
GWI30_RS20135	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWI30_RS20145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWI30_RS20170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWI30_RS20175	COG0569	domain protein
GWI30_RS20180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWI30_RS20185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWI30_RS20190	COG3005	denitrification pathway
GWI30_RS20195	COG0243	molybdopterin cofactor binding
GWI30_RS20205	COG2205	protein histidine kinase activity
GWI30_RS20210	COG0745	RESPONSE REGULATOR receiver
GWI30_RS20225	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GWI30_RS20240	COG2204	response regulator
GWI30_RS20250	COG2205	protein histidine kinase activity
GWI30_RS20270	COG0517	IMP dehydrogenase activity
GWI30_RS20270	COG0516	GMP reductase activity
GWI30_RS20275	COG5413	integral membrane protein
GWI30_RS20285	COG1522	sequence-specific DNA binding
GWI30_RS20290	COG2502	aspartate--ammonia ligase
GWI30_RS20295	COG0542	response to heat
GWI30_RS20305	COG0564	pseudouridine synthase activity
GWI30_RS20310	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWI30_RS20315	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWI30_RS20325	COG3681	Belongs to the UPF0597 family
GWI30_RS20330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GWI30_RS20335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GWI30_RS20340	COG1979	alcohol dehydrogenase
GWI30_RS20345	COG2207	Transcriptional regulator
GWI30_RS20350	COG3040	lipid binding
GWI30_RS20365	COG0688	phosphatidylethanolamine metabolic process
GWI30_RS20380	COG0540	Belongs to the ATCase OTCase family
GWI30_RS20385	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWI30_RS20390	COG1438	arginine binding
GWI30_RS20395	COG1288	antiporter activity
GWI30_RS20400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWI30_RS20425	COG4211	Belongs to the binding-protein-dependent transport system permease family
GWI30_RS20440	COG3250	beta-galactosidase activity
GWI30_RS20445	COG1609	Transcriptional regulator
GWI30_RS20450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWI30_RS20460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWI30_RS20465	COG2017	converts alpha-aldose to the beta-anomer
GWI30_RS20470	COG0667	Aldo Keto reductase
GWI30_RS20475	COG1968	undecaprenyl-diphosphatase activity
GWI30_RS20480	COG3806	Anti-sigma factor
GWI30_RS20485	COG1595	DNA-templated transcription, initiation
GWI30_RS20495	COG0018	arginyl-trna synthetase
GWI30_RS20505	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWI30_RS20510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWI30_RS20530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWI30_RS20535	COG1131	(ABC) transporter
GWI30_RS20540	COG0842	Transport permease protein
GWI30_RS20545	COG0842	Transport permease protein
GWI30_RS20550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWI30_RS20555	COG2146	nitrite reductase [NAD(P)H] activity
GWI30_RS20560	COG2116	formate transmembrane transporter activity
GWI30_RS20565	COG1648	precorrin-2 dehydrogenase activity
GWI30_RS20565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWI30_RS20570	COG2239	Acts as a magnesium transporter
GWI30_RS20575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWI30_RS20580	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GWI30_RS20590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GWI30_RS20600	COG0514	ATP-dependent DNA helicase (RecQ)
GWI30_RS20605	COG2050	protein possibly involved in aromatic compounds catabolism
GWI30_RS20630	COG2258	MOSC domain
GWI30_RS20635	COG1177	transmembrane transport
GWI30_RS20640	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWI30_RS20645	COG3842	ATPase activity
GWI30_RS20665	COG0174	glutamine synthetase
GWI30_RS20670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWI30_RS20685	COG3045	CreA protein
GWI30_RS20690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWI30_RS20695	COG0443	Heat shock 70 kDa protein
GWI30_RS20710	COG0366	Alpha amylase catalytic
GWI30_RS20725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWI30_RS20730	COG0745	RESPONSE REGULATOR receiver
GWI30_RS20735	COG2205	protein histidine kinase activity
GWI30_RS20750	COG0281	malic enzyme
GWI30_RS20755	COG0702	epimerase
GWI30_RS20760	COG0254	rRNA binding
GWI30_RS20765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWI30_RS20780	COG3039	Transposase
GWI30_RS20790	COG0129	dihydroxy-acid dehydratase activity
GWI30_RS20795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWI30_RS20800	COG3978	acetolactate synthase activity
GWI30_RS20810	COG0606	chelatase, subunit chli
GWI30_RS20815	COG0204	Acyl-transferase
GWI30_RS20820	COG0204	Acyl-transferase
GWI30_RS20825	COG1683	Conserved Protein
GWI30_RS20835	COG1335	isochorismatase
GWI30_RS20845	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GWI30_RS20850	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWI30_RS20855	COG3639	organic phosphonate transmembrane transporter activity
GWI30_RS20860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWI30_RS20865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWI30_RS20875	COG3084	Protein conserved in bacteria
GWI30_RS20880	COG3706	GGDEF domain
GWI30_RS20880	COG5001	Diguanylate cyclase
GWI30_RS20880	COG4251	negative regulation of phosphorylation
GWI30_RS20880	COG2203	Gaf domain
GWI30_RS20885	COG0789	Transcriptional regulator
GWI30_RS20895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWI30_RS20900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GWI30_RS20905	COG1561	YicC-like family, N-terminal region
GWI30_RS20920	COG1519	Transferase
GWI30_RS20925	COG0859	PFAM glycosyl transferase family 9
GWI30_RS20930	COG0463	Glycosyl transferase, family 2
GWI30_RS20935	COG0859	PFAM glycosyl transferase family 9
GWI30_RS20940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWI30_RS20945	COG2990	Protein conserved in bacteria
GWI30_RS20950	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWI30_RS20960	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWI30_RS20965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWI30_RS20970	COG2003	Belongs to the UPF0758 family
GWI30_RS20975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWI30_RS20980	COG0756	dUTP diphosphatase activity
GWI30_RS20985	COG1309	transcriptional regulator
GWI30_RS20990	COG0668	transmembrane transport
GWI30_RS21000	COG0166	Belongs to the GPI family
GWI30_RS21010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWI30_RS21015	COG0583	DNA-binding transcription factor activity
GWI30_RS21025	COG1042	CoA-binding domain protein
GWI30_RS21025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWI30_RS21025	COG0045	succinate-CoA ligase (ADP-forming) activity
GWI30_RS21055	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GWI30_RS21060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWI30_RS21065	COG1739	Uncharacterized protein family UPF0029
GWI30_RS21070	COG0006	proline dipeptidase activity
GWI30_RS21075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWI30_RS21080	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWI30_RS21080	COG1024	Enoyl-CoA hydratase
GWI30_RS21085	COG0183	Belongs to the thiolase family
GWI30_RS21090	COG0745	RESPONSE REGULATOR receiver
GWI30_RS21100	COG1653	transport
GWI30_RS21115	COG0425	Belongs to the sulfur carrier protein TusA family
GWI30_RS21120	COG0251	oxidation-reduction process
GWI30_RS21125	COG2885	chlorophyll binding
GWI30_RS21155	COG2818	Glycosylase
GWI30_RS21160	COG0752	glycyl-tRNA synthetase alpha subunit
GWI30_RS21165	COG0751	glycine-tRNA ligase activity
GWI30_RS21180	COG0814	amino acid
GWI30_RS21185	COG0814	amino acid
GWI30_RS21190	COG3039	Transposase
GWI30_RS21200	COG0348	domain, Protein
GWI30_RS21210	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWI30_RS21215	COG1773	rubredoxin
GWI30_RS21215	COG0426	domain, Protein
GWI30_RS21220	COG3604	Transcriptional regulator
GWI30_RS21230	COG1609	Transcriptional regulator
GWI30_RS21240	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWI30_RS21270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWI30_RS21285	COG2960	long-chain fatty acid transporting porin activity
GWI30_RS21300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GWI30_RS21310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GWI30_RS21315	COG3118	belongs to the thioredoxin family
GWI30_RS21320	COG0513	Belongs to the DEAD box helicase family
GWI30_RS21325	COG0248	Ppx GppA phosphatase
GWI30_RS21340	COG0742	ribosomal rna small subunit methyltransferase
GWI30_RS21360	COG0084	hydrolase, TatD family'
GWI30_RS21365	COG0805	protein transport
GWI30_RS21370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWI30_RS21375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWI30_RS21380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWI30_RS21385	COG3165	ubiquinone biosynthetic process from chorismate
GWI30_RS21390	COG2226	methyltransferase
GWI30_RS21395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWI30_RS21400	COG0402	S-adenosylhomocysteine deaminase activity
GWI30_RS21405	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GWI30_RS21445	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GWI30_RS21450	COG0848	biopolymer transport protein
GWI30_RS21455	COG0811	peptide transport
GWI30_RS21460	COG0811	peptide transport
GWI30_RS21475	COG5433	transposase activity
GWI30_RS21480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWI30_RS21485	COG1349	DNA-binding transcription factor activity
GWI30_RS21490	COG0745	RESPONSE REGULATOR receiver
GWI30_RS21495	COG2205	protein histidine kinase activity
GWI30_RS21505	COG4452	Inner membrane protein CreD
GWI30_RS21510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GWI30_RS21515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GWI30_RS21520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GWI30_RS21525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GWI30_RS21530	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GWI30_RS21535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWI30_RS21540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GWI30_RS21550	COG0356	it plays a direct role in the translocation of protons across the membrane
GWI30_RS21560	COG1475	DNA binding
GWI30_RS21565	COG1192	Involved in chromosome partitioning
GWI30_RS21570	COG0357	Ribosomal RNA small subunit methyltransferase G
GWI30_RS21575	COG0445	tRNA wobble uridine modification
GWI30_RS21580	COG0716	FMN binding
GWI30_RS21585	COG4774	siderophore transport
GWI30_RS21590	COG4615	Cyclic peptide transporter
GWI30_RS21595	COG1120	ATPase activity
GWI30_RS21600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWI30_RS21605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWI30_RS21615	COG3550	peptidyl-serine autophosphorylation
GWI30_RS21655	COG5433	transposase activity
GWI30_RS21685	COG4974	Belongs to the 'phage' integrase family
GWI30_RS21690	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWI30_RS21695	COG0706	membrane insertase activity
GWI30_RS21700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWI30_RS21705	COG0594	ribonuclease P activity
GWI30_RS21710	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GWI30_RS21800	COG5433	transposase activity
GWI30_RS21835	COG0675	Transposase, IS605 OrfB family
GWI30_RS21845	COG0210	DNA helicase
GWI30_RS21900	COG5433	transposase activity
GWI30_RS21940	COG2801	Transposase and inactivated derivatives
GWI30_RS21945	COG1397	ADP-ribosylglycohydrolase
GWI30_RS21950	COG1397	ADP-ribosylglycohydrolase
GWI30_RS21965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWI30_RS21970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWI30_RS21975	COG0629	single-stranded DNA binding
GWI30_RS21985	COG1199	ATP-dependent helicase activity
GWI30_RS21995	COG4584	PFAM Integrase catalytic
GWI30_RS22000	COG1484	DNA-dependent DNA replication
GWI30_RS22005	COG3328	transposase activity
GWI30_RS22010	COG5433	transposase activity
GWI30_RS22030	COG1518	maintenance of DNA repeat elements
GWI30_RS22035	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GWI30_RS22130	COG0675	Transposase, IS605 OrfB family
GWI30_RS22140	COG3385	transposase activity
GWI30_RS22150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWI30_RS22190	COG3385	transposase activity
GWI30_RS22215	COG0675	Transposase, IS605 OrfB family
GWI30_RS22285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWI30_RS22300	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GWI30_RS22305	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GWI30_RS22345	COG0783	Belongs to the Dps family
GWI30_RS22355	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GWI30_RS22360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWI30_RS22390	COG1342	Belongs to the UPF0251 family
GWI30_RS22445	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GWI30_RS22470	COG0675	Transposase, IS605 OrfB family
GWI30_RS22530	COG0675	Transposase, IS605 OrfB family
GWI30_RS22565	COG0629	single-stranded DNA binding
GWI30_RS22570	COG0675	Transposase, IS605 OrfB family
GWI30_RS22590	COG0675	Transposase, IS605 OrfB family
GWI30_RS22665	COG0675	Transposase, IS605 OrfB family
GWI30_RS22695	COG0675	Transposase, IS605 OrfB family
GWI30_RS22755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWI30_RS22785	COG5433	transposase activity
GWI30_RS22795	COG3300	MHYT domain
GWI30_RS22795	COG5001	Diguanylate cyclase
GWI30_RS22815	COG5433	transposase activity
GWI30_RS22855	COG1695	Transcriptional regulator
GWI30_RS22865	COG3316	Transposase and inactivated derivatives
GWI30_RS22880	COG3173	Aminoglycoside phosphotransferase
GWI30_RS22885	COG3316	Transposase and inactivated derivatives
GWI30_RS22900	COG1660	Displays ATPase and GTPase activities
GWI30_RS22940	COG0653	protein targeting
GWI30_RS22950	COG4584	PFAM Integrase catalytic
GWI30_RS22955	COG1484	DNA-dependent DNA replication
GWI30_RS22965	COG5433	transposase activity
GWI30_RS23000	COG0675	Transposase, IS605 OrfB family
GWI30_RS23045	COG4804	nuclease activity
GWI30_RS23115	COG4644	lycopene metabolic process
GWI30_RS23130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWI30_RS23145	COG1136	(ABC) transporter
GWI30_RS23160	COG1309	transcriptional regulator
GWI30_RS23175	COG1192	Involved in chromosome partitioning
GWI30_RS23180	COG1192	Involved in chromosome partitioning
GWI30_RS23200	COG2026	Addiction module toxin, RelE StbE family
GWI30_RS23205	COG3077	Addiction module antitoxin, RelB DinJ family