locus-tag	class	description
E4187_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4187_RS00010	COG0592	DNA-directed DNA polymerase activity
E4187_RS00020	COG0187	DNA topoisomerase II activity
E4187_RS00030	COG2378	regulation of single-species biofilm formation
E4187_RS00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4187_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
E4187_RS00050	COG0071	Belongs to the small heat shock protein (HSP20) family
E4187_RS00055	COG3977	Valine--pyruvate aminotransferase
E4187_RS00070	COG2814	Major facilitator Superfamily
E4187_RS00075	COG0745	RESPONSE REGULATOR receiver
E4187_RS00080	COG2205	protein histidine kinase activity
E4187_RS00100	COG1733	regulation of RNA biosynthetic process
E4187_RS00105	COG2267	carboxylic ester hydrolase activity
E4187_RS00110	COG0604	alcohol dehydrogenase
E4187_RS00115	COG0300	oxidoreductase activity
E4187_RS00120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4187_RS00125	COG4191	Histidine kinase
E4187_RS00125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4187_RS00130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4187_RS00135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4187_RS00140	COG1309	transcriptional regulator
E4187_RS00170	COG0561	phosphatase activity
E4187_RS00175	COG2267	carboxylic ester hydrolase activity
E4187_RS00180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4187_RS00185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4187_RS00190	COG1758	RNA polymerase activity
E4187_RS00200	COG0859	PFAM glycosyl transferase family 9
E4187_RS00205	COG3642	lipopolysaccharide core region biosynthetic process
E4187_RS00245	COG0589	response to stress
E4187_RS00250	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4187_RS00255	COG3706	GGDEF domain
E4187_RS00260	COG1528	Iron-storage protein
E4187_RS00265	COG2081	HI0933 family
E4187_RS00270	COG2223	nitrite transmembrane transporter activity
E4187_RS00280	COG3275	phosphorelay sensor kinase activity
E4187_RS00285	COG3279	Response regulator of the LytR AlgR family
E4187_RS00290	COG2223	nitrite transmembrane transporter activity
E4187_RS00295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4187_RS00305	COG4206	TonB-dependent receptor
E4187_RS00310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4187_RS00340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4187_RS00340	COG1042	CoA-binding domain protein
E4187_RS00340	COG0045	succinate-CoA ligase (ADP-forming) activity
E4187_RS00350	COG0583	DNA-binding transcription factor activity
E4187_RS00355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4187_RS00360	COG0166	Belongs to the GPI family
E4187_RS00370	COG0668	transmembrane transport
E4187_RS00375	COG1309	transcriptional regulator
E4187_RS00385	COG0756	dUTP diphosphatase activity
E4187_RS00390	COG3039	Transposase
E4187_RS00415	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4187_RS00420	COG1538	Outer membrane efflux protein
E4187_RS00425	COG1484	DNA-dependent DNA replication
E4187_RS00430	COG4584	PFAM Integrase catalytic
E4187_RS00450	COG0745	RESPONSE REGULATOR receiver
E4187_RS00500	COG2132	Multicopper oxidase
E4187_RS00510	COG3039	Transposase
E4187_RS00525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4187_RS00530	COG2003	Belongs to the UPF0758 family
E4187_RS00535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4187_RS00540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4187_RS00550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4187_RS00555	COG2990	Protein conserved in bacteria
E4187_RS00560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4187_RS00565	COG0859	PFAM glycosyl transferase family 9
E4187_RS00570	COG0463	Glycosyl transferase, family 2
E4187_RS00575	COG0859	PFAM glycosyl transferase family 9
E4187_RS00580	COG1519	Transferase
E4187_RS00590	COG1561	YicC-like family, N-terminal region
E4187_RS00595	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4187_RS00600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4187_RS00610	COG0789	Transcriptional regulator
E4187_RS00615	COG4251	negative regulation of phosphorylation
E4187_RS00615	COG2203	Gaf domain
E4187_RS00615	COG5001	Diguanylate cyclase
E4187_RS00615	COG3706	GGDEF domain
E4187_RS00620	COG3084	Protein conserved in bacteria
E4187_RS00630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4187_RS00635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4187_RS00640	COG3639	organic phosphonate transmembrane transporter activity
E4187_RS00645	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4187_RS00650	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4187_RS00660	COG1335	isochorismatase
E4187_RS00670	COG1683	Conserved Protein
E4187_RS00675	COG0204	Acyl-transferase
E4187_RS00680	COG0204	Acyl-transferase
E4187_RS00685	COG0606	chelatase, subunit chli
E4187_RS00695	COG3978	acetolactate synthase activity
E4187_RS00705	COG0129	dihydroxy-acid dehydratase activity
E4187_RS00730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4187_RS00735	COG0254	rRNA binding
E4187_RS00740	COG0702	epimerase
E4187_RS00745	COG0281	malic enzyme
E4187_RS00755	COG2205	protein histidine kinase activity
E4187_RS00760	COG0745	RESPONSE REGULATOR receiver
E4187_RS00765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4187_RS00780	COG0366	Alpha amylase catalytic
E4187_RS00795	COG0443	Heat shock 70 kDa protein
E4187_RS00800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4187_RS00805	COG3045	CreA protein
E4187_RS00825	COG0174	glutamine synthetase
E4187_RS00845	COG3842	ATPase activity
E4187_RS00850	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4187_RS00855	COG1177	transmembrane transport
E4187_RS00860	COG2258	MOSC domain
E4187_RS00880	COG2050	protein possibly involved in aromatic compounds catabolism
E4187_RS00885	COG0514	ATP-dependent DNA helicase (RecQ)
E4187_RS00895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4187_RS00905	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4187_RS00910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4187_RS00915	COG2239	Acts as a magnesium transporter
E4187_RS00920	COG1648	precorrin-2 dehydrogenase activity
E4187_RS00920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4187_RS00925	COG2116	formate transmembrane transporter activity
E4187_RS00940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4187_RS00945	COG0842	Transport permease protein
E4187_RS00950	COG0842	Transport permease protein
E4187_RS00955	COG1131	(ABC) transporter
E4187_RS00960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4187_RS00980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4187_RS00985	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4187_RS00995	COG0018	arginyl-trna synthetase
E4187_RS01005	COG1595	DNA-templated transcription, initiation
E4187_RS01010	COG3806	Anti-sigma factor
E4187_RS01015	COG1968	undecaprenyl-diphosphatase activity
E4187_RS01020	COG0667	Aldo Keto reductase
E4187_RS01025	COG2017	converts alpha-aldose to the beta-anomer
E4187_RS01030	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4187_RS01040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4187_RS01045	COG1609	Transcriptional regulator
E4187_RS01050	COG3250	beta-galactosidase activity
E4187_RS01065	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4187_RS01095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4187_RS01100	COG1288	antiporter activity
E4187_RS01105	COG1438	arginine binding
E4187_RS01110	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4187_RS01115	COG0540	Belongs to the ATCase OTCase family
E4187_RS01145	COG3040	lipid binding
E4187_RS01150	COG2207	Transcriptional regulator
E4187_RS01155	COG1979	alcohol dehydrogenase
E4187_RS01160	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4187_RS01165	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4187_RS01170	COG3681	Belongs to the UPF0597 family
E4187_RS01180	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4187_RS01185	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4187_RS01190	COG0564	pseudouridine synthase activity
E4187_RS01200	COG0542	response to heat
E4187_RS01205	COG2502	aspartate--ammonia ligase
E4187_RS01210	COG1522	sequence-specific DNA binding
E4187_RS01220	COG5413	integral membrane protein
E4187_RS01225	COG0516	GMP reductase activity
E4187_RS01225	COG0517	IMP dehydrogenase activity
E4187_RS01245	COG2205	protein histidine kinase activity
E4187_RS01255	COG2204	response regulator
E4187_RS01270	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4187_RS01285	COG0745	RESPONSE REGULATOR receiver
E4187_RS01290	COG2205	protein histidine kinase activity
E4187_RS01300	COG0243	molybdopterin cofactor binding
E4187_RS01305	COG3005	denitrification pathway
E4187_RS01310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4187_RS01315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4187_RS01320	COG0569	domain protein
E4187_RS01325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4187_RS01350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4187_RS01365	COG0250	Participates in transcription elongation, termination and antitermination
E4187_RS01370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4187_RS01375	COG0081	regulation of translation
E4187_RS01380	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4187_RS01385	COG0222	ribosome binding
E4187_RS01390	COG0085	RNA polymerase activity
E4187_RS01395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4187_RS01400	COG2964	Protein conserved in bacteria
E4187_RS01420	COG2168	tRNA wobble position uridine thiolation
E4187_RS01425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4187_RS01430	COG0049	tRNA binding
E4187_RS01435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4187_RS01440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4187_RS01445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4187_RS01480	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E4187_RS01485	COG2252	PERMEase
E4187_RS01490	COG2376	Dihydroxyacetone kinase
E4187_RS01495	COG1461	Dihydroxyacetone kinase
E4187_RS01510	COG3284	Transcriptional regulator
E4187_RS01520	COG0628	permease
E4187_RS01545	COG0753	catalase activity
E4187_RS01550	COG0454	-acetyltransferase
E4187_RS01550	COG0456	acetyltransferase
E4187_RS01570	COG2203	Gaf domain
E4187_RS01570	COG2199	diguanylate cyclase activity
E4187_RS01580	COG3842	ATPase activity
E4187_RS01590	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4187_RS01615	COG0583	DNA-binding transcription factor activity
E4187_RS01625	COG1741	Belongs to the pirin family
E4187_RS01630	COG2259	Doxx family
E4187_RS01635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4187_RS01640	COG1074	ATP-dependent DNA helicase activity
E4187_RS01645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4187_RS01665	COG0346	lactoylglutathione lyase activity
E4187_RS01675	COG0004	ammonium transporteR
E4187_RS01680	COG0347	Belongs to the P(II) protein family
E4187_RS01685	COG3706	GGDEF domain
E4187_RS01705	COG0745	RESPONSE REGULATOR receiver
E4187_RS01710	COG2205	protein histidine kinase activity
E4187_RS01715	COG1278	Cold shock
E4187_RS01735	COG1396	sequence-specific DNA binding
E4187_RS01765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4187_RS01805	COG1396	sequence-specific DNA binding
E4187_RS01875	COG2197	response regulator
E4187_RS01880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4187_RS01885	COG3047	cAMP biosynthetic process
E4187_RS01935	COG4221	oxidoreductase activity
E4187_RS01950	COG1979	alcohol dehydrogenase
E4187_RS01960	COG2873	o-acetylhomoserine
E4187_RS01990	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4187_RS02000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4187_RS02005	COG2949	membrane
E4187_RS02010	COG3291	Pkd domain containing protein
E4187_RS02015	COG0318	PFAM AMP-dependent synthetase and ligase
E4187_RS02020	COG1441	menaquinone biosynthetic process
E4187_RS02025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4187_RS02030	COG0596	Alpha beta hydrolase
E4187_RS02035	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E4187_RS02040	COG1169	isochorismate synthase
E4187_RS02045	COG1575	Belongs to the MenA family. Type 1 subfamily
E4187_RS02070	COG0513	Belongs to the DEAD box helicase family
E4187_RS02075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4187_RS02090	COG1671	Belongs to the UPF0178 family
E4187_RS02115	COG3722	fumarate hydratase activity
E4187_RS02120	COG0246	Mannitol dehydrogenase
E4187_RS02125	COG2213	PTS system mannitol-specific
E4187_RS02125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4187_RS02130	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E4187_RS02145	COG2771	luxR family
E4187_RS02160	COG1560	Kdo2-lipid A biosynthetic process
E4187_RS02165	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4187_RS02165	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4187_RS02170	COG1538	Outer membrane efflux protein
E4187_RS02175	COG0494	nUDIX hydrolase
E4187_RS02180	COG3151	Protein conserved in bacteria
E4187_RS02190	COG3150	esterase
E4187_RS02195	COG1051	belongs to the nudix hydrolase family
E4187_RS02285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4187_RS02305	COG0204	Acyl-transferase
E4187_RS02310	COG1842	Phage shock protein A
E4187_RS02325	COG2827	Endonuclease containing a URI domain
E4187_RS02330	COG2962	Rard protein
E4187_RS02335	COG1573	uracil-dna glycosylase
E4187_RS02345	COG0583	DNA-binding transcription factor activity
E4187_RS02350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4187_RS02355	COG1121	(ABC) transporter
E4187_RS02360	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4187_RS02380	COG0739	heme binding
E4187_RS02390	COG3068	Protein conserved in bacteria
E4187_RS02410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4187_RS02420	COG1546	Belongs to the CinA family
E4187_RS02425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4187_RS02435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4187_RS02440	COG0527	aspartate kinase activity
E4187_RS02445	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4187_RS02480	COG1686	Belongs to the peptidase S11 family
E4187_RS02485	COG0586	Pfam SNARE associated Golgi protein
E4187_RS02490	COG1253	flavin adenine dinucleotide binding
E4187_RS02505	COG2927	DNA polymerase III (CHI subunit)
E4187_RS02510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4187_RS02515	COG0795	lipopolysaccharide-transporting ATPase activity
E4187_RS02520	COG0795	lipopolysaccharide-transporting ATPase activity
E4187_RS02540	COG0004	ammonium transporteR
E4187_RS02545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4187_RS02565	COG0084	hydrolase, TatD family'
E4187_RS02570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4187_RS02580	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4187_RS02585	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4187_RS02590	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4187_RS02605	COG3064	Membrane
E4187_RS02615	COG0560	Phosphoserine phosphatase
E4187_RS02630	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4187_RS02640	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E4187_RS02645	COG0776	regulation of translation
E4187_RS02660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4187_RS02665	COG0735	belongs to the Fur family
E4187_RS02685	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4187_RS02690	COG0513	Belongs to the DEAD box helicase family
E4187_RS02695	COG3022	response to hydroperoxide
E4187_RS02710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4187_RS02715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4187_RS02720	COG0762	integral membrane protein
E4187_RS02725	COG1872	DUF167
E4187_RS02745	COG3112	Uncharacterised protein family (UPF0231)
E4187_RS02750	COG3835	regulator
E4187_RS02755	COG2610	gluconate transmembrane transporter activity
E4187_RS02760	COG1929	Belongs to the glycerate kinase type-1 family
E4187_RS02775	COG0583	DNA-binding transcription factor activity
E4187_RS02780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4187_RS02795	COG0347	Belongs to the P(II) protein family
E4187_RS02800	COG1840	ABC-type Fe3 transport system, periplasmic component
E4187_RS02810	COG3842	ATPase activity
E4187_RS02815	COG2837	iron assimilation
E4187_RS02820	COG1438	arginine binding
E4187_RS02825	COG1126	abc transporter atp-binding protein
E4187_RS02830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4187_RS02835	COG4215	(ABC) transporter
E4187_RS02840	COG4160	amino acid transport
E4187_RS02845	COG0039	L-malate dehydrogenase activity
E4187_RS02850	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4187_RS02855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4187_RS02855	COG1017	nitric oxide dioxygenase activity
E4187_RS02865	COG4536	flavin adenine dinucleotide binding
E4187_RS02870	COG4137	Cytochrome C assembly protein
E4187_RS02875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4187_RS02880	COG0228	four-way junction DNA binding
E4187_RS02885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4187_RS02890	COG0336	Belongs to the RNA methyltransferase TrmD family
E4187_RS02895	COG0335	large ribosomal subunit rRNA binding
E4187_RS02910	COG1051	belongs to the nudix hydrolase family
E4187_RS02920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4187_RS02930	COG4974	Belongs to the 'phage' integrase family
E4187_RS02955	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4187_RS02960	COG3039	Transposase
E4187_RS02970	COG2194	sulfuric ester hydrolase activity
E4187_RS02980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4187_RS02985	COG5642	Protein of unknown function (DUF2384)
E4187_RS03010	COG5433	transposase activity
E4187_RS03030	COG4584	PFAM Integrase catalytic
E4187_RS03035	COG1484	DNA-dependent DNA replication
E4187_RS03045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4187_RS03055	COG0583	DNA-binding transcription factor activity
E4187_RS03060	COG0640	Transcriptional regulator
E4187_RS03065	COG0268	Binds directly to 16S ribosomal RNA
E4187_RS03070	COG0728	peptidoglycan biosynthetic process
E4187_RS03075	COG0196	riboflavin kinase activity
E4187_RS03080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4187_RS03085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4187_RS03090	COG1047	Peptidyl-prolyl cis-trans
E4187_RS03095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4187_RS03125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4187_RS03125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4187_RS03140	COG1854	S-ribosylhomocysteine lyase activity
E4187_RS03145	COG3706	GGDEF domain
E4187_RS03150	COG0557	exoribonuclease II activity
E4187_RS03155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4187_RS03165	COG2153	protein acetylation
E4187_RS03180	COG1914	H( )-stimulated, divalent metal cation uptake system
E4187_RS03185	COG0360	Binds together with S18 to 16S ribosomal RNA
E4187_RS03190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4187_RS03195	COG0359	binds to the 23S rRNA
E4187_RS03225	COG1064	alcohol dehydrogenase
E4187_RS03230	COG1238	metal cluster binding
E4187_RS03235	COG0612	Peptidase, M16
E4187_RS03240	COG2918	glutathione biosynthetic process
E4187_RS03245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4187_RS03250	COG1027	Aspartate ammonia-lyase
E4187_RS03255	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4187_RS03260	COG0534	Mate efflux family protein
E4187_RS03265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4187_RS03270	COG0459	protein refolding
E4187_RS03290	COG0564	pseudouridine synthase activity
E4187_RS03295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4187_RS03325	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4187_RS03335	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4187_RS03340	COG4208	sulfate ABC transporter
E4187_RS03345	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4187_RS03350	COG0583	DNA-binding transcription factor activity
E4187_RS03360	COG3397	chitin binding
E4187_RS03365	COG0840	transmembrane signaling receptor activity
E4187_RS03390	COG1328	CTP reductase activity
E4187_RS03395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4187_RS03410	COG1448	Aminotransferase
E4187_RS03435	COG1215	transferase activity, transferring glycosyl groups
E4187_RS03445	COG0457	Tetratricopeptide repeat
E4187_RS03445	COG3118	belongs to the thioredoxin family
E4187_RS03480	COG0513	Belongs to the DEAD box helicase family
E4187_RS03500	COG0840	transmembrane signaling receptor activity
E4187_RS03510	COG4166	transmembrane transport
E4187_RS03525	COG1024	Enoyl-CoA hydratase
E4187_RS03540	COG4221	oxidoreductase activity
E4187_RS03545	COG0442	prolyl-tRNA aminoacylation
E4187_RS03550	COG0632	four-way junction helicase activity
E4187_RS03555	COG2255	four-way junction helicase activity
E4187_RS03565	COG1271	oxidase subunit
E4187_RS03570	COG1294	oxidase, subunit
E4187_RS03575	COG4890	Cyd operon protein YbgT
E4187_RS03580	COG3790	cyd operon protein YbgE
E4187_RS03585	COG0824	Thioesterase
E4187_RS03590	COG0811	peptide transport
E4187_RS03605	COG0823	Involved in the tonB-independent uptake of proteins
E4187_RS03610	COG2885	chlorophyll binding
E4187_RS03615	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4187_RS03690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4187_RS03700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4187_RS03705	COG1640	4-alpha-glucanotransferase
E4187_RS03710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4187_RS03735	COG2130	NADP-dependent
E4187_RS03740	COG1846	Transcriptional regulator
E4187_RS03770	COG0561	phosphatase activity
E4187_RS03785	COG0733	neurotransmitter:sodium symporter activity
E4187_RS03790	COG0733	neurotransmitter:sodium symporter activity
E4187_RS03805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4187_RS03820	COG1794	racemase activity, acting on amino acids and derivatives
E4187_RS03830	COG1022	Amp-dependent synthetase and ligase
E4187_RS03840	COG0456	acetyltransferase
E4187_RS03855	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4187_RS03860	COG3300	MHYT domain
E4187_RS03860	COG5001	Diguanylate cyclase
E4187_RS03870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4187_RS03880	COG1902	pentaerythritol trinitrate reductase activity
E4187_RS03900	COG2957	Belongs to the agmatine deiminase family
E4187_RS03905	COG0154	amidase activity
E4187_RS03915	COG3039	Transposase
E4187_RS03935	COG0513	Belongs to the DEAD box helicase family
E4187_RS03940	COG3706	GGDEF domain
E4187_RS03950	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4187_RS04010	COG1484	DNA-dependent DNA replication
E4187_RS04015	COG4584	PFAM Integrase catalytic
E4187_RS04030	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4187_RS04035	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4187_RS04040	COG1178	ABC-type Fe3 transport system permease component
E4187_RS04045	COG4143	(ABC) transporter
E4187_RS04060	COG0066	3-isopropylmalate dehydratase activity
E4187_RS04065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4187_RS04070	COG0473	3-isopropylmalate dehydrogenase activity
E4187_RS04075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4187_RS04085	COG0671	phosphoesterase, PA-phosphatase related
E4187_RS04090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4187_RS04100	COG0028	Belongs to the TPP enzyme family
E4187_RS04105	COG0440	acetolactate synthase activity
E4187_RS04110	COG0857	belongs to the CobB CobQ family
E4187_RS04110	COG0280	phosphate acetyltransferase
E4187_RS04115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4187_RS04125	COG3013	Belongs to the UPF0304 family
E4187_RS04130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4187_RS04135	COG2716	regulation of RNA biosynthetic process
E4187_RS04140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4187_RS04145	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4187_RS04150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4187_RS04185	COG5002	protein histidine kinase activity
E4187_RS04185	COG2198	Histidine kinase
E4187_RS04185	COG0784	Response regulator, receiver
E4187_RS04190	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4187_RS04225	COG0840	transmembrane signaling receptor activity
E4187_RS04235	COG1464	Belongs to the NlpA lipoprotein family
E4187_RS04240	COG2011	ABC-type metal ion transport system permease component
E4187_RS04245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4187_RS04265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4187_RS04265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4187_RS04270	COG0802	atpase or kinase
E4187_RS04280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4187_RS04285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4187_RS04290	COG1923	regulation of RNA biosynthetic process
E4187_RS04295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4187_RS04300	COG0330	HflC and HflK could
E4187_RS04305	COG0330	HflC and HflK could
E4187_RS04310	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4187_RS04315	COG0142	geranyltranstransferase activity
E4187_RS04320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4187_RS04325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4187_RS04330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4187_RS04340	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4187_RS04345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4187_RS04355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4187_RS04360	COG2967	ApaG domain
E4187_RS04365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4187_RS04370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4187_RS04380	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4187_RS04385	COG3178	'Phosphotransferase
E4187_RS04390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4187_RS04395	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4187_RS04405	COG2252	PERMEase
E4187_RS04415	COG0488	(ABC) transporter
E4187_RS04420	COG0741	lytic transglycosylase activity
E4187_RS04425	COG0463	Glycosyl transferase, family 2
E4187_RS04435	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4187_RS04460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4187_RS04470	COG3721	Heme iron utilization protein
E4187_RS04475	COG0748	coenzyme F420 binding
E4187_RS04500	COG2814	Major facilitator Superfamily
E4187_RS04505	COG2205	protein histidine kinase activity
E4187_RS04535	COG1765	OsmC-like protein
E4187_RS04550	COG3954	Phosphoribulokinase
E4187_RS04555	COG3089	Belongs to the UPF0270 family
E4187_RS04565	COG0429	hydrolase of the alpha beta-hydrolase fold
E4187_RS04570	COG0835	chemotaxis
E4187_RS04570	COG0784	Response regulator, receiver
E4187_RS04580	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4187_RS04585	COG1047	Peptidyl-prolyl cis-trans
E4187_RS04600	COG0545	Peptidyl-prolyl cis-trans isomerase
E4187_RS04625	COG0737	Belongs to the 5'-nucleotidase family
E4187_RS04640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4187_RS04645	COG0506	proline dehydrogenase activity
E4187_RS04645	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4187_RS04645	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4187_RS04655	COG0114	fumarate hydratase activity
E4187_RS04695	COG2200	EAL domain
E4187_RS04695	COG2199	diguanylate cyclase activity
E4187_RS04695	COG2203	Gaf domain
E4187_RS04730	COG1280	lysine exporter protein (LysE YggA)
E4187_RS04740	COG0826	peptidase U32
E4187_RS04750	COG3813	Protein conserved in bacteria
E4187_RS04770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4187_RS04795	COG0300	oxidoreductase activity
E4187_RS04815	COG2610	gluconate transmembrane transporter activity
E4187_RS04820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4187_RS04825	COG3622	Belongs to the hyi family
E4187_RS04830	COG0235	Class ii aldolase
E4187_RS04835	COG3395	kinase activity
E4187_RS04840	COG2084	Dehydrogenase
E4187_RS04845	COG1349	DNA-binding transcription factor activity
E4187_RS04855	COG2133	pyrroloquinoline quinone binding
E4187_RS04870	COG1609	Transcriptional regulator
E4187_RS04890	COG1175	transmembrane transport
E4187_RS04905	COG3940	Belongs to the glycosyl hydrolase 43 family
E4187_RS04920	COG4580	involved in the transport of maltose and maltodextrins
E4187_RS04925	COG5433	transposase activity
E4187_RS04930	COG4580	involved in the transport of maltose and maltodextrins
E4187_RS04955	COG1605	Chorismate mutase
E4187_RS04955	COG0077	Prephenate dehydratase
E4187_RS04980	COG3272	Protein of unknown function (DUF1722)
E4187_RS04985	COG0789	Transcriptional regulator
E4187_RS04990	COG0415	Belongs to the DNA photolyase family
E4187_RS05000	COG0300	oxidoreductase activity
E4187_RS05015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4187_RS05040	COG0783	Belongs to the Dps family
E4187_RS05045	COG1151	hydroxylamine reductase activity
E4187_RS05050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4187_RS05055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4187_RS05080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4187_RS05090	COG0798	PFAM Bile acid sodium symporter
E4187_RS05095	COG1393	Belongs to the ArsC family
E4187_RS05120	COG0659	secondary active sulfate transmembrane transporter activity
E4187_RS05125	COG2771	luxR family
E4187_RS05135	COG3501	Rhs element vgr protein
E4187_RS05150	COG3039	Transposase
E4187_RS05175	COG1666	GTP binding
E4187_RS05180	COG3248	Nucleoside-binding outer membrane protein
E4187_RS05185	COG2211	Major facilitator Superfamily
E4187_RS05195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4187_RS05205	COG2813	Specifically methylates the guanine in position
E4187_RS05210	COG0271	Belongs to the BolA IbaG family
E4187_RS05215	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4187_RS05220	COG1805	sodium ion transport
E4187_RS05225	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4187_RS05230	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4187_RS05235	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4187_RS05240	COG2871	sodium ion transport
E4187_RS05245	COG1477	protein flavinylation
E4187_RS05260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4187_RS05265	COG0840	transmembrane signaling receptor activity
E4187_RS05270	COG0583	DNA-binding transcription factor activity
E4187_RS05280	COG2363	Small membrane protein
E4187_RS05285	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E4187_RS05295	COG0473	3-isopropylmalate dehydrogenase activity
E4187_RS05300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4187_RS05305	COG1611	Belongs to the LOG family
E4187_RS05310	COG3706	GGDEF domain
E4187_RS05320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4187_RS05320	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4187_RS05330	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E4187_RS05355	COG3098	single-species biofilm formation
E4187_RS05360	COG0564	pseudouridine synthase activity
E4187_RS05370	COG4580	involved in the transport of maltose and maltodextrins
E4187_RS05380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4187_RS05380	COG1263	PTS System
E4187_RS05390	COG2171	N-acyltransferase activity
E4187_RS05395	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4187_RS05400	COG0024	Methionine aminopeptidase
E4187_RS05405	COG0052	Belongs to the universal ribosomal protein uS2 family
E4187_RS05410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4187_RS05415	COG0528	UMP kinase activity
E4187_RS05420	COG0233	cytoplasmic translational termination
E4187_RS05425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4187_RS05430	COG0575	Belongs to the CDS family
E4187_RS05435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4187_RS05440	COG0750	zinc metalloprotease
E4187_RS05455	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4187_RS05460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4187_RS05465	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4187_RS05470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4187_RS05475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4187_RS05485	COG0825	malonyl-CoA metabolic process
E4187_RS05495	COG0583	DNA-binding transcription factor activity
E4187_RS05500	COG0814	amino acid
E4187_RS05505	COG0531	amino acid
E4187_RS05525	COG3590	peptidase
E4187_RS05530	COG0037	tRNA processing
E4187_RS05535	COG3706	GGDEF domain
E4187_RS05570	COG0366	Alpha amylase catalytic
E4187_RS05585	COG0463	Glycosyl transferase, family 2
E4187_RS05600	COG2989	Protein conserved in bacteria
E4187_RS05605	COG3108	Peptidase M15
E4187_RS05615	COG2860	membrane
E4187_RS05625	COG1196	nuclear chromosome segregation
E4187_RS05630	COG3115	cell septum assembly
E4187_RS05635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4187_RS05645	COG1328	CTP reductase activity
E4187_RS05650	COG0602	queuosine metabolic process
E4187_RS05675	COG1566	PFAM secretion protein HlyD family protein
E4187_RS05690	COG0281	malic enzyme
E4187_RS05695	COG3290	protein histidine kinase activity
E4187_RS05705	COG0697	spore germination
E4187_RS05715	COG1012	belongs to the aldehyde dehydrogenase family
E4187_RS05720	COG3284	Transcriptional regulator
E4187_RS05725	COG3706	GGDEF domain
E4187_RS05730	COG3039	Transposase
E4187_RS05735	COG0346	lactoylglutathione lyase activity
E4187_RS05740	COG0745	RESPONSE REGULATOR receiver
E4187_RS05745	COG5002	protein histidine kinase activity
E4187_RS05755	COG4783	chaperone-mediated protein folding
E4187_RS05765	COG1940	carbohydrate kinase activity
E4187_RS05770	COG3142	Participates in the control of copper homeostasis
E4187_RS05775	COG0545	Peptidyl-prolyl cis-trans isomerase
E4187_RS05780	COG1131	(ABC) transporter
E4187_RS05795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4187_RS05800	COG4597	amino acid ABC transporter
E4187_RS05805	COG0765	amino acid transport
E4187_RS05810	COG1126	abc transporter atp-binding protein
E4187_RS05820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4187_RS05825	COG0678	peroxiredoxin activity
E4187_RS05835	COG0019	diaminopimelate decarboxylase activity
E4187_RS05840	COG1115	amino acid carrier protein
E4187_RS05845	COG0095	Lipoate-protein ligase
E4187_RS05850	COG2233	PERMEase
E4187_RS05865	COG0534	Mate efflux family protein
E4187_RS05875	COG0281	malic enzyme
E4187_RS05905	COG0733	neurotransmitter:sodium symporter activity
E4187_RS05910	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4187_RS05915	COG3706	GGDEF domain
E4187_RS05925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4187_RS05930	COG1032	radical SAM domain protein
E4187_RS05940	COG5433	transposase activity
E4187_RS05965	COG0673	inositol 2-dehydrogenase activity
E4187_RS05970	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4187_RS05975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4187_RS05980	COG0739	heme binding
E4187_RS05980	COG1196	nuclear chromosome segregation
E4187_RS05980	COG0741	lytic transglycosylase activity
E4187_RS06005	COG0788	formyltetrahydrofolate deformylase activity
E4187_RS06010	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4187_RS06020	COG3118	belongs to the thioredoxin family
E4187_RS06030	COG0791	NLP P60 protein
E4187_RS06035	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E4187_RS06050	COG1376	ErfK ybiS ycfS ynhG family protein
E4187_RS06050	COG1388	LysM domain
E4187_RS06070	COG3901	Regulator of nitric oxide reductase transcription
E4187_RS06070	COG0348	domain, Protein
E4187_RS06075	COG4263	nitrous-oxide reductase activity
E4187_RS06090	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4187_RS06100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4187_RS06175	COG2205	protein histidine kinase activity
E4187_RS06175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4187_RS06175	COG2198	Histidine kinase
E4187_RS06175	COG0784	Response regulator, receiver
E4187_RS06180	COG4584	PFAM Integrase catalytic
E4187_RS06185	COG1484	DNA-dependent DNA replication
E4187_RS06195	COG3384	dioxygenase
E4187_RS06205	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4187_RS06215	COG0531	amino acid
E4187_RS06220	COG0531	amino acid
E4187_RS06240	COG1396	sequence-specific DNA binding
E4187_RS06240	COG1917	Cupin 2, conserved barrel domain protein
E4187_RS06245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4187_RS06265	COG2974	May be involved in recombination
E4187_RS06270	COG0456	acetyltransferase
E4187_RS06275	COG0420	3'-5' exonuclease activity
E4187_RS06285	COG3038	cytochrome b561
E4187_RS06290	COG2190	(PTS) system
E4187_RS06300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4187_RS06305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4187_RS06310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4187_RS06325	COG1720	tRNA m6t6A37 methyltransferase activity
E4187_RS06345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4187_RS06350	COG4988	ABC transporter
E4187_RS06365	COG0745	RESPONSE REGULATOR receiver
E4187_RS06375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4187_RS06410	COG3153	acetyltransferase
E4187_RS06430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4187_RS06435	COG2867	negative regulation of translational initiation
E4187_RS06460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4187_RS06475	COG0564	pseudouridine synthase activity
E4187_RS06505	COG1280	lysine exporter protein (LysE YggA)
E4187_RS06520	COG3263	regulation of cellular component size
E4187_RS06530	COG1876	peptidase activity
E4187_RS06535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4187_RS06540	COG1393	Belongs to the ArsC family
E4187_RS06555	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4187_RS06565	COG1902	pentaerythritol trinitrate reductase activity
E4187_RS06575	COG1028	Short-chain dehydrogenase reductase Sdr
E4187_RS06575	COG3321	synthase
E4187_RS06575	COG0604	alcohol dehydrogenase
E4187_RS06580	COG0017	Asparaginyl-tRNA synthetase
E4187_RS06600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4187_RS06605	COG0156	8-amino-7-oxononanoate synthase activity
E4187_RS06610	COG1073	alpha beta
E4187_RS06610	COG2226	methyltransferase
E4187_RS06615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4187_RS06620	COG0501	Belongs to the peptidase M48B family
E4187_RS06625	COG3217	Mosc domain protein beta barrel domain protein
E4187_RS06625	COG0633	Ferredoxin
E4187_RS06625	COG3217	Mosc domain protein beta barrel domain protein
E4187_RS06625	COG0633	Ferredoxin
E4187_RS06635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4187_RS06635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4187_RS06635	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4187_RS06635	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4187_RS06645	COG2841	Protein conserved in bacteria
E4187_RS06655	COG0534	Mate efflux family protein
E4187_RS06690	COG1309	transcriptional regulator
E4187_RS06705	COG0791	NLP P60 protein
E4187_RS06710	COG0583	DNA-binding transcription factor activity
E4187_RS06730	COG0500	methyltransferase
E4187_RS06735	COG4106	trans-aconitate 2-methyltransferase activity
E4187_RS06740	COG1801	Protein of unknown function DUF72
E4187_RS06745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4187_RS06750	COG0217	transcriptional regulatory protein
E4187_RS06760	COG1940	carbohydrate kinase activity
E4187_RS06760	COG1846	Transcriptional regulator
E4187_RS06765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4187_RS06770	COG0363	glucosamine-6-phosphate deaminase activity
E4187_RS06775	COG2190	(PTS) system
E4187_RS06775	COG1263	PTS System
E4187_RS06775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4187_RS06785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4187_RS06790	COG0735	belongs to the Fur family
E4187_RS06800	COG0716	FMN binding
E4187_RS06815	COG0596	Alpha beta hydrolase
E4187_RS06820	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4187_RS06825	COG0033	Phosphoglucomutase
E4187_RS06835	COG1846	Transcriptional regulator
E4187_RS06840	COG2951	lytic endotransglycosylase activity
E4187_RS06845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4187_RS06850	COG4136	ATPase activity
E4187_RS06860	COG4134	Bacterial extracellular solute-binding protein
E4187_RS06870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4187_RS06880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4187_RS06890	COG0729	surface antigen
E4187_RS06915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4187_RS06925	COG0741	lytic transglycosylase activity
E4187_RS06940	COG1607	acyl-coa hydrolase
E4187_RS06955	COG0741	lytic transglycosylase activity
E4187_RS06955	COG1388	LysM domain
E4187_RS06960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4187_RS06965	COG2226	methyltransferase
E4187_RS06970	COG0328	RNA-DNA hybrid ribonuclease activity
E4187_RS06975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4187_RS06985	COG0784	Response regulator, receiver
E4187_RS06985	COG3437	response regulator, receiver
E4187_RS06990	COG1960	acyl-CoA dehydrogenase activity
E4187_RS06995	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4187_RS07000	COG0121	glutamine amidotransferase
E4187_RS07010	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4187_RS07035	COG2197	response regulator
E4187_RS07040	COG3850	Histidine kinase
E4187_RS07045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4187_RS07050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4187_RS07060	COG0243	molybdopterin cofactor binding
E4187_RS07065	COG0437	4 iron, 4 sulfur cluster binding
E4187_RS07070	COG0348	domain, Protein
E4187_RS07080	COG3005	denitrification pathway
E4187_RS07085	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4187_RS07090	COG0315	cyclic pyranopterin monophosphate synthase activity
E4187_RS07095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4187_RS07100	COG0314	molybdopterin synthase activity
E4187_RS07115	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4187_RS07120	COG0596	Alpha beta hydrolase
E4187_RS07125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4187_RS07135	COG0302	gtp cyclohydrolase
E4187_RS07140	COG0840	transmembrane signaling receptor activity
E4187_RS07145	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4187_RS07155	COG0583	DNA-binding transcription factor activity
E4187_RS07160	COG2353	YceI-like domain
E4187_RS07170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4187_RS07185	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4187_RS07195	COG1166	arginine decarboxylase activity
E4187_RS07250	COG5433	transposase activity
E4187_RS07265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4187_RS07270	COG1187	pseudouridine synthase activity
E4187_RS07275	COG2807	transmembrane transport
E4187_RS07315	COG2979	Protein of unknown function (DUF533)
E4187_RS07330	COG1595	DNA-templated transcription, initiation
E4187_RS07345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4187_RS07355	COG1294	oxidase, subunit
E4187_RS07365	COG2814	Major facilitator Superfamily
E4187_RS07370	COG0656	L-ascorbic acid biosynthetic process
E4187_RS07390	COG0583	DNA-binding transcription factor activity
E4187_RS07395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4187_RS07400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4187_RS07405	COG2271	Major facilitator Superfamily
E4187_RS07410	COG1349	DNA-binding transcription factor activity
E4187_RS07420	COG0584	glycerophosphoryl diester phosphodiesterase
E4187_RS07425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4187_RS07430	COG1605	Chorismate mutase
E4187_RS07430	COG0287	Prephenate dehydrogenase
E4187_RS07440	COG3085	chromosome segregation
E4187_RS07445	COG4574	serine-type endopeptidase inhibitor activity
E4187_RS07465	COG1770	oligopeptidase
E4187_RS07470	COG4206	TonB-dependent receptor
E4187_RS07475	COG3083	sulfuric ester hydrolase activity
E4187_RS07480	COG3082	Protein of unknown function (DUF1414)
E4187_RS07485	COG3081	Nucleoid-associated protein
E4187_RS07490	COG2182	Extracellular solute-binding protein
E4187_RS07495	COG1175	transmembrane transport
E4187_RS07500	COG3833	ABC-type maltose transport systems, permease component
E4187_RS07505	COG3842	ATPase activity
E4187_RS07535	COG4783	chaperone-mediated protein folding
E4187_RS07545	COG1393	Belongs to the ArsC family
E4187_RS07555	COG1228	amidohydrolase
E4187_RS07570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4187_RS07575	COG2431	L-lysine efflux transmembrane transporter activity
E4187_RS07585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4187_RS07605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4187_RS07615	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4187_RS07635	COG2271	Major facilitator Superfamily
E4187_RS07675	COG2373	Large extracellular alpha-helical protein
E4187_RS07680	COG4953	penicillin-binding protein 1C
E4187_RS07695	COG0301	tRNA thio-modification
E4187_RS07695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4187_RS07715	COG1334	flagellar protein FlaG
E4187_RS07750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4187_RS07760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4187_RS07775	COG0346	lactoylglutathione lyase activity
E4187_RS07780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4187_RS07785	COG4660	Part of a membrane complex involved in electron transport
E4187_RS07790	COG4659	FMN binding
E4187_RS07795	COG4658	electron transport chain
E4187_RS07800	COG4656	Part of a membrane complex involved in electron transport
E4187_RS07805	COG2878	Part of a membrane complex involved in electron transport
E4187_RS07810	COG4657	Part of a membrane complex involved in electron transport
E4187_RS07815	COG0697	spore germination
E4187_RS07835	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4187_RS07840	COG1288	antiporter activity
E4187_RS07845	COG0436	Aminotransferase
E4187_RS07855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4187_RS07860	COG2027	D-alanyl-D-alanine carboxypeptidase
E4187_RS07865	COG1061	Type III restriction enzyme res subunit
E4187_RS07870	COG1566	PFAM secretion protein HlyD family protein
E4187_RS07880	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4187_RS07880	COG3264	Mechanosensitive ion channel
E4187_RS07885	COG1966	Carbon starvation protein
E4187_RS07890	COG3279	Response regulator of the LytR AlgR family
E4187_RS07895	COG3275	phosphorelay sensor kinase activity
E4187_RS07905	COG1454	alcohol dehydrogenase
E4187_RS07905	COG1012	belongs to the aldehyde dehydrogenase family
E4187_RS07910	COG2095	MarC family integral membrane protein
E4187_RS07920	COG0601	transmembrane transport
E4187_RS07925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4187_RS07930	COG0444	Belongs to the ABC transporter superfamily
E4187_RS07940	COG0861	Integral membrane protein TerC family
E4187_RS07945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4187_RS07955	COG1301	dicarboxylic acid transport
E4187_RS07970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4187_RS07985	COG0537	adenosine 5'-monophosphoramidase activity
E4187_RS08020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4187_RS08025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4187_RS08035	COG2354	Protein conserved in bacteria
E4187_RS08050	COG3150	esterase
E4187_RS08055	COG1252	NADH dehydrogenase
E4187_RS08070	COG0393	Putative heavy-metal-binding
E4187_RS08075	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4187_RS08080	COG1368	sulfuric ester hydrolase activity
E4187_RS08090	COG0527	aspartate kinase activity
E4187_RS08100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4187_RS08100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4187_RS08105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4187_RS08120	COG2315	Protein conserved in bacteria
E4187_RS08130	COG0583	DNA-binding transcription factor activity
E4187_RS08135	COG1620	l-lactate permease
E4187_RS08140	COG0247	lactate metabolic process
E4187_RS08145	COG1139	Iron-sulfur cluster binding protein
E4187_RS08185	COG3039	Transposase
E4187_RS08205	COG1136	(ABC) transporter
E4187_RS08225	COG2814	Major facilitator Superfamily
E4187_RS08245	COG0493	'glutamate synthase
E4187_RS08245	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E4187_RS08250	COG0672	)-iron permease
E4187_RS08285	COG2308	Evidence 4 Homologs of previously reported genes of
E4187_RS08305	COG0659	secondary active sulfate transmembrane transporter activity
E4187_RS08320	COG5433	transposase activity
E4187_RS08330	COG3039	Transposase
E4187_RS08345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4187_RS08350	COG1028	Short-chain dehydrogenase reductase Sdr
E4187_RS08355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4187_RS08360	COG1902	pentaerythritol trinitrate reductase activity
E4187_RS08365	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4187_RS08375	COG4974	Belongs to the 'phage' integrase family
E4187_RS08380	COG3039	Transposase
E4187_RS08390	COG3039	Transposase
E4187_RS08395	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4187_RS08400	COG0437	4 iron, 4 sulfur cluster binding
E4187_RS08405	COG5557	Pfam Polysulphide reductase, NrfD
E4187_RS08410	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4187_RS08415	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4187_RS08420	COG1773	rubredoxin
E4187_RS08430	COG0601	transmembrane transport
E4187_RS08435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4187_RS08440	COG0444	Belongs to the ABC transporter superfamily
E4187_RS08445	COG1124	(ABC) transporter
E4187_RS08450	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4187_RS08455	COG0375	protein maturation
E4187_RS08460	COG0309	Hydrogenase expression formation protein (HypE)
E4187_RS08470	COG0298	carbon dioxide binding
E4187_RS08475	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4187_RS08480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4187_RS08485	COG0326	Molecular chaperone. Has ATPase activity
E4187_RS08490	COG0563	adenylate kinase activity
E4187_RS08495	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4187_RS08505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4187_RS08510	COG0840	transmembrane signaling receptor activity
E4187_RS08525	COG3300	MHYT domain
E4187_RS08525	COG5001	Diguanylate cyclase
E4187_RS08530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4187_RS08550	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4187_RS08555	COG3433	isochorismatase activity
E4187_RS08555	COG1535	isochorismatase
E4187_RS08560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4187_RS08565	COG1028	Short-chain dehydrogenase reductase Sdr
E4187_RS08575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4187_RS08580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4187_RS08590	COG1120	ATPase activity
E4187_RS08595	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4187_RS08600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4187_RS08605	COG4771	TonB-dependent receptor
E4187_RS08630	COG0644	oxidoreductase
E4187_RS08630	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4187_RS08650	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4187_RS08655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4187_RS08660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4187_RS08665	COG0861	Integral membrane protein TerC family
E4187_RS08680	COG1022	Amp-dependent synthetase and ligase
E4187_RS08685	COG0295	cytidine deaminase activity
E4187_RS08690	COG1346	cytolysis
E4187_RS08695	COG1380	Effector of murein hydrolase LrgA
E4187_RS08700	COG3345	alpha-galactosidase
E4187_RS08710	COG2925	Exonuclease
E4187_RS08715	COG0582	viral genome integration into host DNA
E4187_RS08780	COG1846	Transcriptional regulator
E4187_RS08795	COG3646	Phage regulatory protein
E4187_RS08810	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4187_RS08855	COG4626	Terminase
E4187_RS08855	COG1802	Transcriptional regulator
E4187_RS08960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4187_RS08965	COG0392	lysyltransferase activity
E4187_RS08965	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4187_RS08980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4187_RS08985	COG0436	Aminotransferase
E4187_RS08990	COG0583	DNA-binding transcription factor activity
E4187_RS08995	COG2160	L-arabinose isomerase activity
E4187_RS09005	COG1069	ribulokinase activity
E4187_RS09010	COG1879	ABC-type sugar transport system periplasmic component
E4187_RS09020	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4187_RS09030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4187_RS09035	COG0254	rRNA binding
E4187_RS09045	COG2731	YhcH YjgK YiaL family protein
E4187_RS09050	COG0800	Aldolase
E4187_RS09055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4187_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
E4187_RS09090	COG1451	nucleotide metabolic process
E4187_RS09105	COG3069	C4-dicarboxylate transmembrane transporter activity
E4187_RS09115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4187_RS09115	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4187_RS09120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4187_RS09145	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4187_RS09150	COG1053	succinate dehydrogenase
E4187_RS09160	COG0567	Dehydrogenase, E1 component
E4187_RS09165	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4187_RS09170	COG0045	succinate-CoA ligase (ADP-forming) activity
E4187_RS09175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4187_RS09190	COG2983	Belongs to the UPF0260 family
E4187_RS09195	COG1882	Formate acetyltransferase
E4187_RS09200	COG2116	formate transmembrane transporter activity
E4187_RS09205	COG1944	ATP diphosphatase activity
E4187_RS09225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4187_RS09230	COG1278	Cold shock
E4187_RS09235	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4187_RS09240	COG0542	response to heat
E4187_RS09245	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4187_RS09250	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4187_RS09255	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4187_RS09260	COG3134	Outer membrane lipoprotein
E4187_RS09265	COG3706	GGDEF domain
E4187_RS09270	COG0492	ferredoxin-NADP+ reductase activity
E4187_RS09275	COG0686	Belongs to the AlaDH PNT family
E4187_RS09285	COG0531	amino acid
E4187_RS09285	COG1674	ftsk spoiiie
E4187_RS09290	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4187_RS09295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4187_RS09300	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4187_RS09305	COG1286	toxin biosynthetic process
E4187_RS09310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4187_RS09315	COG2723	6-phospho-beta-galactosidase activity
E4187_RS09320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4187_RS09320	COG1263	PTS System
E4187_RS09325	COG1609	Transcriptional regulator
E4187_RS09335	COG4172	Belongs to the ABC transporter superfamily
E4187_RS09345	COG4171	peptide transport system, permease
E4187_RS09350	COG4168	peptide transport system, permease
E4187_RS09360	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4187_RS09365	COG1842	Phage shock protein A
E4187_RS09380	COG3106	COG3106 Predicted ATPase
E4187_RS09385	COG3768	UPF0283 membrane protein
E4187_RS09395	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4187_RS09410	COG2199	diguanylate cyclase activity
E4187_RS09415	COG2885	chlorophyll binding
E4187_RS09425	COG1570	exodeoxyribonuclease VII activity
E4187_RS09435	COG1874	Beta-galactosidase
E4187_RS09435	COG0366	Alpha amylase catalytic
E4187_RS09445	COG0516	GMP reductase activity
E4187_RS09445	COG0517	IMP dehydrogenase activity
E4187_RS09450	COG0519	Catalyzes the synthesis of GMP from XMP
E4187_RS09450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4187_RS09480	COG2062	phosphohistidine phosphatase, SixA
E4187_RS09490	COG0697	spore germination
E4187_RS09495	COG4166	transmembrane transport
E4187_RS09500	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4187_RS09505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4187_RS09515	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4187_RS09520	COG1136	(ABC) transporter
E4187_RS09525	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4187_RS09540	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4187_RS09545	COG0740	serine-type endopeptidase activity
E4187_RS09550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4187_RS09555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4187_RS09560	COG0776	regulation of translation
E4187_RS09565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4187_RS09570	COG0488	(ABC) transporter
E4187_RS09575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4187_RS09580	COG3162	membrane
E4187_RS09585	COG2176	DNA-directed DNA polymerase activity
E4187_RS09595	COG1024	Enoyl-CoA hydratase
E4187_RS09600	COG1115	amino acid carrier protein
E4187_RS09615	COG1584	GPR1 FUN34 yaaH family protein
E4187_RS09640	COG1024	Enoyl-CoA hydratase
E4187_RS09645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4187_RS09650	COG1960	acyl-CoA dehydrogenase activity
E4187_RS09660	COG1960	acyl-CoA dehydrogenase activity
E4187_RS09665	COG1024	Enoyl-CoA hydratase
E4187_RS09670	COG1024	Enoyl-CoA hydratase
E4187_RS09680	COG1028	Short-chain dehydrogenase reductase Sdr
E4187_RS09690	COG0730	response to heat
E4187_RS09710	COG3039	Transposase
E4187_RS09725	COG3039	Transposase
E4187_RS09740	COG5433	transposase activity
E4187_RS09760	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4187_RS09765	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4187_RS09770	COG1129	ABC transporter
E4187_RS09775	COG1879	ABC-type sugar transport system periplasmic component
E4187_RS09780	COG0583	DNA-binding transcription factor activity
E4187_RS09795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4187_RS09800	COG0243	molybdopterin cofactor binding
E4187_RS09810	COG3706	GGDEF domain
E4187_RS09815	COG0583	DNA-binding transcription factor activity
E4187_RS09820	COG2723	6-phospho-beta-galactosidase activity
E4187_RS09825	COG1028	Short-chain dehydrogenase reductase Sdr
E4187_RS09830	COG0583	DNA-binding transcription factor activity
E4187_RS09850	COG5433	transposase activity
E4187_RS09855	COG3706	GGDEF domain
E4187_RS09885	COG1742	UPF0060 membrane protein
E4187_RS09900	COG0513	Belongs to the DEAD box helicase family
E4187_RS09905	COG0386	Belongs to the glutathione peroxidase family
E4187_RS09915	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4187_RS09930	COG0730	response to heat
E4187_RS09935	COG0583	DNA-binding transcription factor activity
E4187_RS09950	COG3593	DNA synthesis involved in DNA repair
E4187_RS10000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4187_RS10005	COG1011	Hydrolase
E4187_RS10010	COG1473	amidohydrolase
E4187_RS10015	COG0205	6-phosphofructokinase activity
E4187_RS10025	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4187_RS10030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4187_RS10040	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4187_RS10045	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4187_RS10095	COG2824	Alkylphosphonate utilization operon protein PhnA
E4187_RS10125	COG0406	alpha-ribazole phosphatase activity
E4187_RS10135	COG2840	Smr protein MutS2
E4187_RS10140	COG2890	protein-(glutamine-N5) methyltransferase activity
E4187_RS10145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4187_RS10155	COG0513	Belongs to the DEAD box helicase family
E4187_RS10160	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4187_RS10165	COG0814	amino acid
E4187_RS10170	COG1609	Transcriptional regulator
E4187_RS10175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4187_RS10175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4187_RS10180	COG1105	Belongs to the carbohydrate kinase PfkB family
E4187_RS10185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4187_RS10185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4187_RS10185	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4187_RS10190	COG3313	Fe-S protein
E4187_RS10195	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4187_RS10200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4187_RS10210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4187_RS10220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4187_RS10250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4187_RS10255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4187_RS10260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4187_RS10265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4187_RS10270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4187_RS10275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4187_RS10275	COG0072	phenylalanine-tRNA ligase activity
E4187_RS10280	COG0776	regulation of translation
E4187_RS10285	COG0784	Response regulator, receiver
E4187_RS10285	COG2205	protein histidine kinase activity
E4187_RS10310	COG5001	Diguanylate cyclase
E4187_RS10310	COG3300	MHYT domain
E4187_RS10315	COG1609	Transcriptional regulator
E4187_RS10320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4187_RS10325	COG1879	ABC-type sugar transport system periplasmic component
E4187_RS10330	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4187_RS10335	COG1129	ABC transporter
E4187_RS10340	COG1869	D-ribose catabolic process
E4187_RS10360	COG0037	tRNA processing
E4187_RS10365	COG0589	response to stress
E4187_RS10370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4187_RS10395	COG2010	Cytochrome c
E4187_RS10410	COG3278	Belongs to the heme-copper respiratory oxidase family
E4187_RS10420	COG1956	GAF domain-containing protein
E4187_RS10425	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4187_RS10435	COG0308	aminopeptidase N
E4187_RS10445	COG2902	Dehydrogenase
E4187_RS10450	COG0167	dihydroorotate dehydrogenase activity
E4187_RS10460	COG0116	Belongs to the methyltransferase superfamily
E4187_RS10460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4187_RS10470	COG0488	(ABC) transporter
E4187_RS10485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4187_RS10490	COG1067	ATP-dependent peptidase activity
E4187_RS10555	COG3141	response to X-ray
E4187_RS10565	COG2995	paraquat-inducible protein a
E4187_RS10570	COG3008	intermembrane lipid transfer
E4187_RS10575	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E4187_RS10575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4187_RS10590	COG0084	hydrolase, TatD family'
E4187_RS10595	COG0470	DNA polymerase III
E4187_RS10600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4187_RS10605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4187_RS10610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4187_RS10620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4187_RS10625	COG1028	Short-chain dehydrogenase reductase Sdr
E4187_RS10635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4187_RS10640	COG0416	fatty acid biosynthetic process
E4187_RS10645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4187_RS10650	COG1399	metal-binding, possibly nucleic acid-binding protein
E4187_RS10660	COG0424	maF-like protein
E4187_RS10665	COG0546	phosphoglycolate phosphatase activity
E4187_RS10675	COG1530	ribonuclease E activity
E4187_RS10680	COG0306	phosphate transporter
E4187_RS10685	COG0717	Belongs to the dCTP deaminase family
E4187_RS10690	COG0572	uridine kinase
E4187_RS10695	COG0489	protein tyrosine kinase activity
E4187_RS10700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4187_RS10700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4187_RS10710	COG1254	Belongs to the acylphosphatase family
E4187_RS10715	COG0840	transmembrane signaling receptor activity
E4187_RS10720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4187_RS10730	COG0709	Synthesizes selenophosphate from selenide and ATP
E4187_RS10735	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4187_RS10740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4187_RS10745	COG3437	response regulator, receiver
E4187_RS10755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4187_RS10765	COG1643	Atp-dependent helicase
E4187_RS10770	COG0517	IMP dehydrogenase activity
E4187_RS10770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4187_RS10770	COG0617	tRNA 3'-terminal CCA addition
E4187_RS10775	COG2197	response regulator
E4187_RS10795	COG1335	isochorismatase
E4187_RS10800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4187_RS10810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4187_RS10815	COG2832	Protein of unknown function (DUF454)
E4187_RS10820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4187_RS10830	COG0697	spore germination
E4187_RS10840	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4187_RS10845	COG0318	PFAM AMP-dependent synthetase and ligase
E4187_RS10850	COG0596	Alpha beta hydrolase
E4187_RS10860	COG1214	PFAM Peptidase M22, glycoprotease
E4187_RS10865	COG1199	ATP-dependent helicase activity
E4187_RS10875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4187_RS10880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4187_RS10885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4187_RS10890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4187_RS10890	COG0131	Imidazoleglycerol-phosphate dehydratase
E4187_RS10895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4187_RS10900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4187_RS10905	COG3437	response regulator, receiver
E4187_RS10915	COG2198	Histidine kinase
E4187_RS10915	COG2205	protein histidine kinase activity
E4187_RS10915	COG0784	Response regulator, receiver
E4187_RS10920	COG0107	imidazoleglycerol-phosphate synthase activity
E4187_RS10925	COG0140	phosphoribosyl-ATP diphosphatase activity
E4187_RS10925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4187_RS10935	COG2378	regulation of single-species biofilm formation
E4187_RS10940	COG0318	PFAM AMP-dependent synthetase and ligase
E4187_RS10945	COG3134	Outer membrane lipoprotein
E4187_RS10960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4187_RS10985	COG4681	YaeQ
E4187_RS10995	COG1024	Enoyl-CoA hydratase
E4187_RS10995	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4187_RS11000	COG0183	Belongs to the thiolase family
E4187_RS11005	COG0714	Associated with various cellular activities
E4187_RS11025	COG2304	oxidoreductase activity
E4187_RS11035	COG1595	DNA-templated transcription, initiation
E4187_RS11045	COG2067	long-chain fatty acid transport protein
E4187_RS11050	COG2067	long-chain fatty acid transport protein
E4187_RS11055	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E4187_RS11060	COG2067	long-chain fatty acid transport protein
E4187_RS11075	COG1301	dicarboxylic acid transport
E4187_RS11080	COG3123	guanosine phosphorylase activity
E4187_RS11085	COG1760	l-serine dehydratase
E4187_RS11090	COG1760	l-serine dehydratase
E4187_RS11095	COG2951	lytic endotransglycosylase activity
E4187_RS11100	COG3100	YcgL domain-containing protein
E4187_RS11105	COG0850	regulation of cytokinetic process
E4187_RS11110	COG2894	cell division
E4187_RS11115	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E4187_RS11120	COG3099	Belongs to the UPF0263 family
E4187_RS11125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4187_RS11165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4187_RS11170	COG0697	spore germination
E4187_RS11175	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4187_RS11180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4187_RS11190	COG0307	riboflavin synthase, alpha
E4187_RS11230	COG0417	DNA replication proofreading
E4187_RS11250	COG1560	Kdo2-lipid A biosynthetic process
E4187_RS11255	COG1560	Kdo2-lipid A biosynthetic process
E4187_RS11265	COG0583	DNA-binding transcription factor activity
E4187_RS11270	COG0673	inositol 2-dehydrogenase activity
E4187_RS11275	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E4187_RS11280	COG2329	Antibiotic biosynthesis monooxygenase
E4187_RS11285	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4187_RS11315	COG2501	S4 domain
E4187_RS11330	COG1132	(ABC) transporter
E4187_RS11335	COG1132	(ABC) transporter
E4187_RS11345	COG3118	belongs to the thioredoxin family
E4187_RS11350	COG0471	metal ion transport
E4187_RS11360	COG0058	SHG alpha-glucan phosphorylase activity
E4187_RS11390	COG0814	amino acid
E4187_RS11395	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4187_RS11400	COG0514	ATP-dependent DNA helicase (RecQ)
E4187_RS11405	COG2766	serine protein kinase
E4187_RS11410	COG2718	Belongs to the UPF0229 family
E4187_RS11415	COG2719	SpoVR family
E4187_RS11425	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4187_RS11430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4187_RS11440	COG0586	Pfam SNARE associated Golgi protein
E4187_RS11450	COG0556	nucleotide-excision repair
E4187_RS11460	COG2985	domain, Protein
E4187_RS11460	COG0569	domain protein
E4187_RS11465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4187_RS11485	COG4565	transcriptional regulatory protein
E4187_RS11490	COG3290	protein histidine kinase activity
E4187_RS11495	COG1940	carbohydrate kinase activity
E4187_RS11495	COG1846	Transcriptional regulator
E4187_RS11505	COG3012	SEC-C Motif Domain Protein
E4187_RS11510	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4187_RS11515	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E4187_RS11520	COG0247	lactate metabolic process
E4187_RS11530	COG5433	transposase activity
E4187_RS11545	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4187_RS11550	COG0437	4 iron, 4 sulfur cluster binding
E4187_RS11555	COG3301	Polysulphide reductase, NrfD
E4187_RS11560	COG1138	Cytochrome C-type biogenesis protein
E4187_RS11565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4187_RS11570	COG4235	cytochrome complex assembly
E4187_RS11570	COG3088	subunit of a heme lyase
E4187_RS11590	COG3046	protein related to deoxyribodipyrimidine photolyase
E4187_RS11595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4187_RS11610	COG0517	IMP dehydrogenase activity
E4187_RS11620	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4187_RS11625	COG0583	DNA-binding transcription factor activity
E4187_RS11635	COG4774	siderophore transport
E4187_RS11640	COG3708	Transcriptional regulator
E4187_RS11640	COG2207	Transcriptional regulator
E4187_RS11650	COG0583	DNA-binding transcription factor activity
E4187_RS11655	COG2910	NAD(P)H-binding
E4187_RS11670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4187_RS11695	COG3039	Transposase
E4187_RS11805	COG3328	transposase activity
E4187_RS11820	COG3550	peptidyl-serine autophosphorylation
E4187_RS11830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4187_RS11855	COG1435	thymidine kinase activity
E4187_RS11860	COG1757	Na H antiporter
E4187_RS11865	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4187_RS11870	COG2096	Adenosyltransferase
E4187_RS11875	COG3530	Putative quorum-sensing-regulated virulence factor
E4187_RS11880	COG0602	queuosine metabolic process
E4187_RS11885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4187_RS11905	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4187_RS11915	COG0776	regulation of translation
E4187_RS11920	COG0539	negative regulation of cytoplasmic translation
E4187_RS11925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4187_RS11930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4187_RS11940	COG2814	Major facilitator Superfamily
E4187_RS11960	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4187_RS11965	COG3300	MHYT domain
E4187_RS11965	COG5001	Diguanylate cyclase
E4187_RS11975	COG0583	DNA-binding transcription factor activity
E4187_RS11980	COG3437	response regulator, receiver
E4187_RS12005	COG4989	oxidoreductase activity
E4187_RS12010	COG0724	RNA recognition motif
E4187_RS12030	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4187_RS12050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4187_RS12055	COG1360	Flagellar Motor Protein
E4187_RS12060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4187_RS12065	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4187_RS12070	COG0649	NAD binding
E4187_RS12070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4187_RS12085	COG1034	ATP synthesis coupled electron transport
E4187_RS12090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4187_RS12095	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4187_RS12100	COG0839	Belongs to the complex I subunit 6 family
E4187_RS12105	COG0713	ATP synthesis coupled electron transport
E4187_RS12115	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4187_RS12120	COG1007	ATP synthesis coupled electron transport
E4187_RS12125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4187_RS12125	COG0047	phosphoribosylformylglycinamidine synthase activity
E4187_RS12130	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4187_RS12140	COG1160	GTP binding
E4187_RS12145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4187_RS12150	COG2976	Protein conserved in bacteria
E4187_RS12155	COG0124	histidyl-tRNA synthetase
E4187_RS12175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4187_RS12180	COG0105	UTP biosynthetic process
E4187_RS12185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4187_RS12195	COG0633	Ferredoxin
E4187_RS12200	COG0443	Heat shock 70 kDa protein
E4187_RS12205	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4187_RS12215	COG0822	iron-sulfur transferase activity
E4187_RS12220	COG1104	cysteine desulfurase activity
E4187_RS12240	COG3154	lipid carrier protein
E4187_RS12245	COG0826	peptidase U32
E4187_RS12250	COG0826	peptidase U32
E4187_RS12265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4187_RS12270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4187_RS12275	COG1862	Preprotein translocase
E4187_RS12280	COG0343	queuine tRNA-ribosyltransferase activity
E4187_RS12285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4187_RS12290	COG0517	IMP dehydrogenase activity
E4187_RS12300	COG3634	alkyl hydroperoxide reductase activity
E4187_RS12330	COG3039	Transposase
E4187_RS12340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4187_RS12340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4187_RS12345	COG0509	glycine decarboxylation via glycine cleavage system
E4187_RS12350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4187_RS12355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4187_RS12360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4187_RS12380	COG2814	Major facilitator Superfamily
E4187_RS12385	COG1136	(ABC) transporter
E4187_RS12385	COG0577	efflux transmembrane transporter activity
E4187_RS12390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4187_RS12395	COG0601	transmembrane transport
E4187_RS12405	COG0625	glutathione transferase activity
E4187_RS12420	COG0483	inositol monophosphate 1-phosphatase activity
E4187_RS12435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4187_RS12440	COG2056	Na+-H+ antiporter family
E4187_RS12445	COG2814	Major facilitator Superfamily
E4187_RS12450	COG0583	DNA-binding transcription factor activity
E4187_RS12455	COG5001	Diguanylate cyclase
E4187_RS12465	COG0513	Belongs to the DEAD box helicase family
E4187_RS12470	COG2050	protein possibly involved in aromatic compounds catabolism
E4187_RS12490	COG1253	flavin adenine dinucleotide binding
E4187_RS12495	COG1902	pentaerythritol trinitrate reductase activity
E4187_RS12500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4187_RS12505	COG0647	UMP catabolic process
E4187_RS12515	COG0367	asparagine synthase
E4187_RS12525	COG0625	glutathione transferase activity
E4187_RS12535	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E4187_RS12550	COG0564	pseudouridine synthase activity
E4187_RS12555	COG3706	GGDEF domain
E4187_RS12565	COG0840	transmembrane signaling receptor activity
E4187_RS12570	COG0318	PFAM AMP-dependent synthetase and ligase
E4187_RS12590	COG4447	cellulose binding
E4187_RS12615	COG2855	membrane
E4187_RS12630	COG2814	Major facilitator Superfamily
E4187_RS12635	COG3246	L-lysine catabolic process to acetate
E4187_RS12640	COG2175	clavaminate synthase activity
E4187_RS12650	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4187_RS12675	COG0670	Belongs to the BI1 family
E4187_RS12680	COG1289	transmembrane transporter activity
E4187_RS12685	COG2920	part of a sulfur-relay system
E4187_RS12690	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4187_RS12695	COG0285	dihydrofolate synthase activity
E4187_RS12700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4187_RS12705	COG0101	tRNA pseudouridine synthase activity
E4187_RS12715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4187_RS12720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4187_RS12725	COG0671	phosphoesterase, PA-phosphatase related
E4187_RS12730	COG1464	Belongs to the NlpA lipoprotein family
E4187_RS12750	COG1119	ATPase activity
E4187_RS12755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4187_RS12755	COG0574	Belongs to the PEP-utilizing enzyme family
E4187_RS12760	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4187_RS12770	COG1113	amino acid transport
E4187_RS12815	COG1242	4 iron, 4 sulfur cluster binding
E4187_RS12820	COG0069	glutamate synthase activity
E4187_RS12820	COG0070	glutamate synthase
E4187_RS12820	COG0067	glutamate synthase
E4187_RS12825	COG0493	'glutamate synthase
E4187_RS12835	COG1126	abc transporter atp-binding protein
E4187_RS12840	COG0765	amino acid transport
E4187_RS12845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4187_RS12860	COG4104	PAAR repeat-containing protein
E4187_RS12870	COG0513	Belongs to the DEAD box helicase family
E4187_RS12900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4187_RS12905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4187_RS12910	COG0505	Belongs to the CarA family
E4187_RS12915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4187_RS12925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4187_RS12930	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4187_RS12935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4187_RS12940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4187_RS12945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4187_RS12950	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
E4187_RS13000	COG2119	membrane
E4187_RS13065	COG3039	Transposase
E4187_RS13075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4187_RS13085	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4187_RS13090	COG2261	transglycosylase associated protein
E4187_RS13095	COG0625	glutathione transferase activity
E4187_RS13180	COG0322	excinuclease ABC activity
E4187_RS13185	COG2197	response regulator
E4187_RS13190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4187_RS13195	COG2835	tetraacyldisaccharide 4'-kinase activity
E4187_RS13200	COG1663	tetraacyldisaccharide 4'-kinase activity
E4187_RS13205	COG1132	(ABC) transporter
E4187_RS13210	COG0658	competence protein
E4187_RS13210	COG2333	competence protein COMEC
E4187_RS13225	COG0433	COG0433 Predicted ATPase
E4187_RS13230	COG1448	Aminotransferase
E4187_RS13245	COG1199	ATP-dependent helicase activity
E4187_RS13255	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4187_RS13260	COG0477	Major facilitator Superfamily
E4187_RS13265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4187_RS13270	COG1785	Belongs to the alkaline phosphatase family
E4187_RS13290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4187_RS13295	COG2197	response regulator
E4187_RS13305	COG2271	Major facilitator Superfamily
E4187_RS13315	COG0675	Transposase, IS605 OrfB family
E4187_RS13330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4187_RS13335	COG0765	amino acid transport
E4187_RS13340	COG1126	abc transporter atp-binding protein
E4187_RS13350	COG0531	amino acid
E4187_RS13365	COG1253	flavin adenine dinucleotide binding
E4187_RS13380	COG0581	inorganic phosphate transmembrane transporter activity
E4187_RS13385	COG0573	inorganic phosphate transmembrane transporter activity
E4187_RS13405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4187_RS13430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4187_RS13435	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4187_RS13440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4187_RS13455	COG3852	Histidine kinase
E4187_RS13470	COG2716	regulation of RNA biosynthetic process
E4187_RS13475	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4187_RS13500	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4187_RS13500	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4187_RS13505	COG1706	bacterial-type flagellum-dependent cell motility
E4187_RS13510	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4187_RS13525	COG4786	Flagellar basal body rod
E4187_RS13540	COG1815	bacterial-type flagellum-dependent cell motility
E4187_RS13545	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4187_RS13550	COG0784	Response regulator, receiver
E4187_RS13550	COG0835	chemotaxis
E4187_RS13555	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4187_RS13570	COG0622	Phosphoesterase
E4187_RS13575	COG4166	transmembrane transport
E4187_RS13585	COG1187	pseudouridine synthase activity
E4187_RS13595	COG0675	Transposase, IS605 OrfB family
E4187_RS13615	COG0697	spore germination
E4187_RS13645	COG1278	Cold shock
E4187_RS13685	COG3132	Protein of unknown function, DUF480
E4187_RS13700	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4187_RS13720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4187_RS13750	COG0297	glycogen (starch) synthase activity
E4187_RS13755	COG0438	transferase activity, transferring glycosyl groups
E4187_RS13805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4187_RS13860	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4187_RS13875	COG0745	RESPONSE REGULATOR receiver
E4187_RS13890	COG1737	Transcriptional regulator
E4187_RS13895	COG0469	pyruvate kinase activity
E4187_RS13905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4187_RS13910	COG1960	acyl-CoA dehydrogenase activity
E4187_RS13920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4187_RS13950	COG5433	transposase activity
E4187_RS13960	COG3039	Transposase
E4187_RS13985	COG3657	addiction module killer protein
E4187_RS14005	COG1484	DNA-dependent DNA replication
E4187_RS14010	COG4584	PFAM Integrase catalytic
E4187_RS14025	COG3039	Transposase
E4187_RS14045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4187_RS14050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4187_RS14055	COG1309	transcriptional regulator
E4187_RS14070	COG1946	Acyl-CoA thioesterase
E4187_RS14080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4187_RS14090	COG0009	L-threonylcarbamoyladenylate synthase
E4187_RS14100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4187_RS14105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4187_RS14105	COG0512	Glutamine amidotransferase of anthranilate synthase
E4187_RS14110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4187_RS14115	COG0135	phosphoribosylanthranilate isomerase activity
E4187_RS14115	COG0134	indole-3-glycerol-phosphate synthase activity
E4187_RS14120	COG0133	tryptophan synthase activity
E4187_RS14125	COG0159	tryptophan synthase activity
E4187_RS14135	COG5433	transposase activity
E4187_RS14140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4187_RS14145	COG1396	sequence-specific DNA binding
E4187_RS14150	COG3550	peptidyl-serine autophosphorylation
E4187_RS14185	COG5507	3-demethylubiquinone-9 3-methyltransferase
E4187_RS14190	COG2814	Major facilitator Superfamily
E4187_RS14200	COG0109	protoheme IX farnesyltransferase activity
E4187_RS14205	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4187_RS14210	COG1845	cytochrome c oxidase, subunit III
E4187_RS14215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4187_RS14220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4187_RS14225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4187_RS14230	COG0583	DNA-binding transcription factor activity
E4187_RS14270	COG0071	Belongs to the small heat shock protein (HSP20) family
E4187_RS14295	COG0708	Exodeoxyribonuclease III
E4187_RS14305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4187_RS14310	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4187_RS14325	COG0095	Lipoate-protein ligase
E4187_RS14370	COG1285	pathogenesis
E4187_RS14400	COG0484	heat shock protein binding
E4187_RS14405	COG0443	Heat shock 70 kDa protein
E4187_RS14410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4187_RS14415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4187_RS14425	COG0497	DNA recombination
E4187_RS14430	COG1227	inorganic diphosphatase activity
E4187_RS14440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4187_RS14445	COG1136	(ABC) transporter
E4187_RS14445	COG0577	efflux transmembrane transporter activity
E4187_RS14455	COG2375	cellular response to nickel ion
E4187_RS14460	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4187_RS14465	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4187_RS14470	COG0583	DNA-binding transcription factor activity
E4187_RS14475	COG2610	gluconate transmembrane transporter activity
E4187_RS14480	COG3048	D-serine ammonia-lyase activity
E4187_RS14490	COG0538	isocitrate dehydrogenase activity
E4187_RS14495	COG2207	Transcriptional regulator
E4187_RS14500	COG1482	cell wall glycoprotein biosynthetic process
E4187_RS14515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4187_RS14520	COG4932	domain protein
E4187_RS14520	COG5492	domain, Protein
E4187_RS14535	COG0583	DNA-binding transcription factor activity
E4187_RS14540	COG4584	PFAM Integrase catalytic
E4187_RS14545	COG1484	DNA-dependent DNA replication
E4187_RS14570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4187_RS14570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4187_RS14570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4187_RS14580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4187_RS14600	COG0482	sulfurtransferase activity
E4187_RS14605	COG2915	High frequency lysogenization protein hflD homolog
E4187_RS14610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4187_RS14615	COG2850	peptidyl-arginine hydroxylation
E4187_RS14620	COG0469	pyruvate kinase activity
E4187_RS14625	COG3264	Mechanosensitive ion channel
E4187_RS14625	COG1196	nuclear chromosome segregation
E4187_RS14635	COG2706	6-phosphogluconolactonase activity
E4187_RS14655	COG0281	malic enzyme
E4187_RS14660	COG0746	molybdenum cofactor guanylyltransferase activity
E4187_RS14665	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4187_RS14670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4187_RS14730	COG4319	ketosteroid isomerase
E4187_RS14735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4187_RS14740	COG0083	homoserine kinase activity
E4187_RS14750	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4187_RS14755	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E4187_RS14765	COG0259	pyridoxamine-phosphate oxidase activity
E4187_RS14790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4187_RS14790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4187_RS14795	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4187_RS14815	COG4235	cytochrome complex assembly
E4187_RS14815	COG3088	subunit of a heme lyase
E4187_RS14820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4187_RS14825	COG1138	Cytochrome C-type biogenesis protein
E4187_RS14830	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4187_RS14835	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4187_RS14840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4187_RS14845	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4187_RS14860	COG0835	chemotaxis
E4187_RS14870	COG1192	Involved in chromosome partitioning
E4187_RS14875	COG1360	Flagellar Motor Protein
E4187_RS14880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4187_RS14885	COG2201	protein-glutamate methylesterase activity
E4187_RS14890	COG2198	Histidine kinase
E4187_RS14890	COG0643	Histidine kinase
E4187_RS14890	COG0784	Response regulator, receiver
E4187_RS14895	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4187_RS14920	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4187_RS14935	COG1684	flagellar biosynthetic protein fliR
E4187_RS14995	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4187_RS15015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4187_RS15030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4187_RS15035	COG0444	Belongs to the ABC transporter superfamily
E4187_RS15040	COG4608	Belongs to the ABC transporter superfamily
E4187_RS15050	COG2971	BadF BadG BcrA BcrD
E4187_RS15060	COG0840	transmembrane signaling receptor activity
E4187_RS15080	COG3724	N-succinylarginine dihydrolase activity
E4187_RS15085	COG0616	signal peptide processing
E4187_RS15090	COG1028	Short-chain dehydrogenase reductase Sdr
E4187_RS15095	COG0583	DNA-binding transcription factor activity
E4187_RS15105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4187_RS15115	COG0583	DNA-binding transcription factor activity
E4187_RS15125	COG1881	PFAM PEBP family protein
E4187_RS15135	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4187_RS15135	COG3408	Glycogen debranching enzyme
E4187_RS15140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4187_RS15145	COG0739	heme binding
E4187_RS15150	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4187_RS15160	COG5433	transposase activity
E4187_RS15195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4187_RS15205	COG3091	SprT-like family
E4187_RS15215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4187_RS15220	COG0189	ligase activity
E4187_RS15240	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4187_RS15270	COG1115	amino acid carrier protein
E4187_RS15275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4187_RS15290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4187_RS15325	COG2912	Transglutaminase-like superfamily
E4187_RS15335	COG2890	protein-(glutamine-N5) methyltransferase activity
E4187_RS15340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4187_RS15345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4187_RS15350	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4187_RS15355	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4187_RS15365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4187_RS15370	COG0737	Belongs to the 5'-nucleotidase family
E4187_RS15375	COG0193	aminoacyl-tRNA hydrolase activity
E4187_RS15380	COG0012	GTP binding
E4187_RS15425	COG0471	metal ion transport
E4187_RS15425	COG0490	domain, Protein
E4187_RS15450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4187_RS15460	COG1012	belongs to the aldehyde dehydrogenase family
E4187_RS15470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4187_RS15485	COG0180	Tryptophanyl-tRNA synthetase
E4187_RS15495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4187_RS15500	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4187_RS15510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4187_RS15515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4187_RS15550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4187_RS15555	COG0583	DNA-binding transcription factor activity
E4187_RS15570	COG0583	DNA-binding transcription factor activity
E4187_RS15585	COG3121	Chaperone
E4187_RS15590	COG3188	usher protein
E4187_RS15595	COG3121	Chaperone
E4187_RS15600	COG0739	heme binding
E4187_RS15610	COG3264	Mechanosensitive ion channel
E4187_RS15610	COG1511	domain protein
E4187_RS15615	COG0584	glycerophosphoryl diester phosphodiesterase
E4187_RS15625	COG1053	succinate dehydrogenase
E4187_RS15630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4187_RS15635	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E4187_RS15645	COG3214	Protein conserved in bacteria
E4187_RS15650	COG4106	trans-aconitate 2-methyltransferase activity
E4187_RS15660	COG1022	Amp-dependent synthetase and ligase
E4187_RS15670	COG0300	oxidoreductase activity
E4187_RS15680	COG0745	RESPONSE REGULATOR receiver
E4187_RS15685	COG0642	Histidine kinase
E4187_RS15695	COG0516	GMP reductase activity
E4187_RS15705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4187_RS15710	COG3647	Membrane
E4187_RS15720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4187_RS15730	COG2199	diguanylate cyclase activity
E4187_RS15745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4187_RS15755	COG0583	DNA-binding transcription factor activity
E4187_RS15760	COG1278	Cold shock
E4187_RS15765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4187_RS15770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4187_RS15775	COG1702	phosphate starvation-inducible protein PhoH
E4187_RS15780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4187_RS15785	COG4535	Mg2 and Co2 transporter CorC
E4187_RS15790	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4187_RS15795	COG2888	peptidyl-tyrosine sulfation
E4187_RS15800	COG0495	leucyl-tRNA aminoacylation
E4187_RS15815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4187_RS15820	COG0799	negative regulation of ribosome biogenesis
E4187_RS15825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4187_RS15830	COG0768	penicillin binding
E4187_RS15835	COG0772	Belongs to the SEDS family
E4187_RS15840	COG2951	lytic endotransglycosylase activity
E4187_RS15845	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4187_RS15850	COG1686	Belongs to the peptidase S11 family
E4187_RS15855	COG2921	Belongs to the UPF0250 family
E4187_RS15860	COG0321	lipoyl(octanoyl) transferase activity
E4187_RS15865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4187_RS15875	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4187_RS15885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4187_RS15910	COG4974	Belongs to the 'phage' integrase family
E4187_RS15930	COG0312	modulator of DNA gyrase
E4187_RS15950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4187_RS15965	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4187_RS15970	COG2211	Major facilitator Superfamily
E4187_RS15975	COG1185	polyribonucleotide nucleotidyltransferase activity
E4187_RS15980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4187_RS15985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4187_RS15990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4187_RS15995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4187_RS16000	COG0195	Participates in both transcription termination and antitermination
E4187_RS16005	COG0779	Required for maturation of 30S ribosomal subunits
E4187_RS16020	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4187_RS16025	COG0149	triose-phosphate isomerase activity
E4187_RS16030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4187_RS16035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4187_RS16045	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4187_RS16050	COG1534	Rna-binding protein
E4187_RS16065	COG1360	Flagellar Motor Protein
E4187_RS16070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4187_RS16075	COG1722	exodeoxyribonuclease VII activity
E4187_RS16080	COG0142	geranyltranstransferase activity
E4187_RS16085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4187_RS16105	COG4172	Belongs to the ABC transporter superfamily
E4187_RS16110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4187_RS16115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4187_RS16120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4187_RS16125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4187_RS16140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4187_RS16140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4187_RS16145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4187_RS16160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4187_RS16170	COG2198	Histidine kinase
E4187_RS16170	COG0784	Response regulator, receiver
E4187_RS16170	COG2205	protein histidine kinase activity
E4187_RS16175	COG1879	ABC-type sugar transport system periplasmic component
E4187_RS16185	COG0745	RESPONSE REGULATOR receiver
E4187_RS16190	COG3005	denitrification pathway
E4187_RS16200	COG3381	protein complex oligomerization
E4187_RS16220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4187_RS16225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4187_RS16230	COG0511	ligase activity, forming carbon-carbon bonds
E4187_RS16235	COG0439	Biotin carboxylase
E4187_RS16240	COG3924	membrane
E4187_RS16245	COG4145	pantothenate transmembrane transporter activity
E4187_RS16250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4187_RS16250	COG2190	(PTS) system
E4187_RS16250	COG1263	PTS System
E4187_RS16255	COG0583	DNA-binding transcription factor activity
E4187_RS16260	COG0604	alcohol dehydrogenase
E4187_RS16265	COG2264	protein methyltransferase activity
E4187_RS16275	COG0778	Nitroreductase
E4187_RS16280	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4187_RS16280	COG1902	pentaerythritol trinitrate reductase activity
E4187_RS16285	COG0616	signal peptide processing
E4187_RS16305	COG3139	Protein of unknown function (DUF1315)
E4187_RS16310	COG0252	asparaginase activity
E4187_RS16315	COG0786	glutamate:sodium symporter activity
E4187_RS16325	COG5001	Diguanylate cyclase
E4187_RS16340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4187_RS16345	COG0384	phenazine biosynthesis protein PhzF
E4187_RS16350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4187_RS16355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4187_RS16360	COG0175	sulfate reduction
E4187_RS16365	COG2113	Glycine betaine
E4187_RS16370	COG4176	ABC-type proline glycine betaine transport system permease component
E4187_RS16375	COG4175	Glycine betaine
E4187_RS16385	COG3610	response to peptide
E4187_RS16390	COG2966	Psort location CytoplasmicMembrane, score
E4187_RS16400	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4187_RS16410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4187_RS16415	COG1028	Short-chain dehydrogenase reductase Sdr
E4187_RS16425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4187_RS16475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4187_RS16480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4187_RS16525	COG2313	pseudouridylate synthase activity
E4187_RS16530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4187_RS16535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4187_RS16535	COG2146	nitrite reductase [NAD(P)H] activity
E4187_RS16540	COG2146	nitrite reductase [NAD(P)H] activity
E4187_RS16540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4187_RS16545	COG1116	anion transmembrane transporter activity
E4187_RS16550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4187_RS16555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4187_RS16555	COG1116	anion transmembrane transporter activity
E4187_RS16570	COG0243	molybdopterin cofactor binding
E4187_RS16595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4187_RS16615	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4187_RS16620	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4187_RS16625	COG4608	Belongs to the ABC transporter superfamily
E4187_RS16635	COG0747	negative chemotaxis
E4187_RS16640	COG4239	(ABC) transporter, permease
E4187_RS16645	COG4174	ABC transporter (Permease)
E4187_RS16650	COG4206	TonB-dependent receptor
E4187_RS16660	COG0811	peptide transport
E4187_RS16665	COG0811	peptide transport
E4187_RS16670	COG0848	biopolymer transport protein
E4187_RS16715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4187_RS16720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4187_RS16725	COG0840	transmembrane signaling receptor activity
E4187_RS16735	COG1278	Cold shock
E4187_RS16775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4187_RS16785	COG0688	phosphatidylethanolamine metabolic process
E4187_RS16790	COG4628	conserved protein (DUF2132)
E4187_RS16805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4187_RS16810	COG2207	Transcriptional regulator
E4187_RS16820	COG5001	Diguanylate cyclase
E4187_RS16820	COG3300	MHYT domain
E4187_RS16825	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4187_RS16840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4187_RS16850	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4187_RS16855	COG2017	converts alpha-aldose to the beta-anomer
E4187_RS16865	COG1609	Transcriptional regulator
E4187_RS16885	COG3039	Transposase
E4187_RS16890	COG0583	DNA-binding transcription factor activity
E4187_RS16915	COG1132	(ABC) transporter
E4187_RS16925	COG2897	thiosulfate sulfurtransferase activity
E4187_RS16930	COG2066	Belongs to the glutaminase family
E4187_RS16935	COG3171	Protein conserved in bacteria
E4187_RS16940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4187_RS16945	COG4935	Belongs to the peptidase S8 family
E4187_RS16945	COG2234	aminopeptidase activity
E4187_RS16950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4187_RS16955	COG2200	EAL domain
E4187_RS16960	COG1090	epimerase
E4187_RS16965	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4187_RS16970	COG4181	ATPase activity
E4187_RS16975	COG2755	lipolytic protein G-D-S-L family
E4187_RS16980	COG0784	Response regulator, receiver
E4187_RS16980	COG0835	chemotaxis
E4187_RS16985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4187_RS16990	COG0517	IMP dehydrogenase activity
E4187_RS16995	COG0488	(ABC) transporter
E4187_RS17005	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4187_RS17035	COG3039	Transposase
E4187_RS17055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4187_RS17060	COG1376	ErfK ybiS ycfS ynhG family protein
E4187_RS17065	COG0668	transmembrane transport
E4187_RS17075	COG2731	YhcH YjgK YiaL family protein
E4187_RS17085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4187_RS17090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4187_RS17100	COG0583	DNA-binding transcription factor activity
E4187_RS17105	COG0477	Major facilitator Superfamily
E4187_RS17115	COG2985	domain, Protein
E4187_RS17115	COG0569	domain protein
E4187_RS17120	COG1272	protein, Hemolysin III
E4187_RS17125	COG0076	glutamate decarboxylase activity
E4187_RS17130	COG2917	probably involved in intracellular septation
E4187_RS17135	COG2350	Protein conserved in bacteria
E4187_RS17145	COG1555	photosystem II stabilization
E4187_RS17150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4187_RS17155	COG3104	oligopeptide transport
E4187_RS17160	COG0745	RESPONSE REGULATOR receiver
E4187_RS17190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4187_RS17200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4187_RS17205	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4187_RS17240	COG1484	DNA-dependent DNA replication
E4187_RS17245	COG4584	PFAM Integrase catalytic
E4187_RS17260	COG3293	Transposase
E4187_RS17305	COG5433	transposase activity
E4187_RS17380	COG2003	Belongs to the UPF0758 family
E4187_RS17430	COG3311	Transcriptional regulator
E4187_RS17490	COG0316	Belongs to the HesB IscA family
E4187_RS17500	COG0038	chloride channel
E4187_RS17505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4187_RS17520	COG0671	phosphoesterase, PA-phosphatase related
E4187_RS17530	COG0583	DNA-binding transcription factor activity
E4187_RS17535	COG2076	Multidrug Resistance protein
E4187_RS17550	COG0346	lactoylglutathione lyase activity
E4187_RS17555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4187_RS17560	COG1643	Atp-dependent helicase
E4187_RS17565	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4187_RS17570	COG1489	DNA binding
E4187_RS17575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4187_RS17580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4187_RS17585	COG0617	tRNA 3'-terminal CCA addition
E4187_RS17595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4187_RS17600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4187_RS17610	COG0842	Transport permease protein
E4187_RS17615	COG1131	(ABC) transporter
E4187_RS17630	COG0163	prenyltransferase activity
E4187_RS17635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4187_RS17640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4187_RS17655	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4187_RS17670	COG1136	(ABC) transporter
E4187_RS17700	COG3039	Transposase
E4187_RS17710	COG0529	Catalyzes the synthesis of activated sulfate
E4187_RS17715	COG3273	potassium ion transport
E4187_RS17715	COG0471	metal ion transport
E4187_RS17720	COG2895	sulfate adenylyltransferase (ATP) activity
E4187_RS17725	COG0175	sulfate reduction
E4187_RS17730	COG1648	precorrin-2 dehydrogenase activity
E4187_RS17730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4187_RS17735	COG0330	HflC and HflK could
E4187_RS17740	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4187_RS17750	COG0673	inositol 2-dehydrogenase activity
E4187_RS17760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4187_RS17765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4187_RS17770	COG3036	rescue of stalled ribosome
E4187_RS17785	COG0138	bifunctional purine biosynthesis protein purh
E4187_RS17790	COG0151	Belongs to the GarS family
E4187_RS17815	COG4584	PFAM Integrase catalytic
E4187_RS17820	COG1484	DNA-dependent DNA replication
E4187_RS17830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4187_RS17835	COG0358	DNA primase activity
E4187_RS17840	COG1610	YqeY-like protein
E4187_RS17845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4187_RS17850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4187_RS17860	COG4942	peptidase
E4187_RS17860	COG1388	LysM domain
E4187_RS17865	COG1238	metal cluster binding
E4187_RS17870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4187_RS17875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E4187_RS17880	COG0585	pseudouridine synthase activity
E4187_RS17890	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4187_RS17895	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4187_RS17900	COG0148	phosphopyruvate hydratase activity
E4187_RS17905	COG0504	CTP synthase activity
E4187_RS17910	COG3956	TIGRFAM MazG family protein
E4187_RS17915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4187_RS17920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4187_RS17930	COG4807	Protein conserved in bacteria
E4187_RS17935	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4187_RS17940	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4187_RS17945	COG1381	Involved in DNA repair and RecF pathway recombination
E4187_RS17955	COG0571	ribonuclease III activity
E4187_RS17960	COG0681	Belongs to the peptidase S26 family
E4187_RS17965	COG0481	GTPase activity
E4187_RS17985	COG1595	DNA-templated transcription, initiation
E4187_RS17990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4187_RS18040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4187_RS18045	COG0191	fructose-bisphosphate aldolase activity
E4187_RS18050	COG0126	phosphoglycerate kinase activity
E4187_RS18055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4187_RS18060	COG1940	carbohydrate kinase activity
E4187_RS18065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4187_RS18075	COG4991	sh3 domain protein
E4187_RS18080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4187_RS18095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4187_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
E4187_RS18110	COG2982	Protein involved in outer membrane biogenesis
E4187_RS18115	COG1505	serine-type exopeptidase activity
E4187_RS18120	COG3174	membrane
E4187_RS18125	COG0110	maltose O-acetyltransferase activity
E4187_RS18140	COG3039	Transposase
E4187_RS18150	COG0165	Argininosuccinate lyase
E4187_RS18155	COG0137	argininosuccinate synthase activity
E4187_RS18165	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4187_RS18170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4187_RS18180	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4187_RS18185	COG5001	Diguanylate cyclase
E4187_RS18185	COG3447	MASE1 domain protein
E4187_RS18185	COG5002	protein histidine kinase activity
E4187_RS18220	COG0583	DNA-binding transcription factor activity
E4187_RS18225	COG1380	Effector of murein hydrolase LrgA
E4187_RS18230	COG1346	cytolysis
E4187_RS18235	COG0460	homoserine dehydrogenase
E4187_RS18235	COG0527	aspartate kinase activity
E4187_RS18240	COG0626	cystathionine gamma-synthase activity
E4187_RS18255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4187_RS18260	COG0814	amino acid
E4187_RS18265	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4187_RS18270	COG0494	nUDIX hydrolase
E4187_RS18275	COG1011	Hydrolase
E4187_RS18280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4187_RS18295	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E4187_RS18305	COG3156	type II secretion system protein K
E4187_RS18315	COG4795	General secretion pathway protein
E4187_RS18320	COG2165	general secretion pathway protein
E4187_RS18330	COG2165	general secretion pathway protein
E4187_RS18335	COG1459	type II secretion system
E4187_RS18340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4187_RS18350	COG3031	protein transport across the cell outer membrane
E4187_RS18360	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4187_RS18365	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E4187_RS18385	COG3133	Outer membrane lipoprotein
E4187_RS18395	COG1392	Phosphate transport regulator
E4187_RS18400	COG0306	phosphate transporter
E4187_RS18405	COG0617	tRNA 3'-terminal CCA addition
E4187_RS18410	COG3267	Type II secretory pathway component ExeA
E4187_RS18410	COG3409	Peptidoglycan-binding domain 1 protein
E4187_RS18420	COG1194	a g-specific adenine glycosylase
E4187_RS18425	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E4187_RS18440	COG3240	lipase activity
E4187_RS18450	COG3009	Protein conserved in bacteria
E4187_RS18455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4187_RS18455	COG3008	intermembrane lipid transfer
E4187_RS18460	COG2995	paraquat-inducible protein a
E4187_RS18470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4187_RS18475	COG2203	Gaf domain
E4187_RS18475	COG4251	negative regulation of phosphorylation
E4187_RS18475	COG5001	Diguanylate cyclase
E4187_RS18475	COG3706	GGDEF domain
E4187_RS18480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4187_RS18485	COG2813	Specifically methylates the guanine in position
E4187_RS18490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4187_RS18495	COG0297	glycogen (starch) synthase activity
E4187_RS18535	COG1757	Na H antiporter
E4187_RS18540	COG0583	DNA-binding transcription factor activity
E4187_RS18545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4187_RS18550	COG3842	ATPase activity
E4187_RS18555	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4187_RS18560	COG1177	transmembrane transport
E4187_RS18565	COG1012	belongs to the aldehyde dehydrogenase family
E4187_RS18570	COG0109	protoheme IX farnesyltransferase activity
E4187_RS18575	COG1612	heme a metabolic process
E4187_RS18600	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4187_RS18605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4187_RS18610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4187_RS18615	COG1444	tRNA N-acetyltransferase activity
E4187_RS18635	COG1803	Methylglyoxal synthase
E4187_RS18650	COG0252	asparaginase activity
E4187_RS18660	COG1609	Transcriptional regulator
E4187_RS18670	COG1940	carbohydrate kinase activity
E4187_RS18675	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4187_RS18680	COG2723	6-phospho-beta-galactosidase activity
E4187_RS18685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4187_RS18685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4187_RS18690	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4187_RS18695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4187_RS18710	COG1263	PTS System
E4187_RS18710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4187_RS18715	COG0366	Alpha amylase catalytic
E4187_RS18720	COG0110	maltose O-acetyltransferase activity
E4187_RS18725	COG1522	sequence-specific DNA binding
E4187_RS18730	COG5006	permease, DMT superfamily
E4187_RS18780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E4187_RS18785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4187_RS18800	COG0477	Major facilitator Superfamily
E4187_RS18805	COG0523	cobalamin synthesis protein
E4187_RS18815	COG1280	lysine exporter protein (LysE YggA)
E4187_RS18825	COG2200	EAL domain
E4187_RS18830	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4187_RS18835	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4187_RS18840	COG0840	transmembrane signaling receptor activity
E4187_RS18855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4187_RS18860	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4187_RS18865	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4187_RS18870	COG2186	Transcriptional regulator
E4187_RS18905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4187_RS18910	COG1459	type II secretion system
E4187_RS18915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E4187_RS18925	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E4187_RS18930	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4187_RS18940	COG0653	protein targeting
E4187_RS18950	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4187_RS18955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4187_RS18960	COG0849	cell division
E4187_RS18965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4187_RS18970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4187_RS18975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4187_RS18980	COG0772	Belongs to the SEDS family
E4187_RS18985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4187_RS18990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4187_RS18995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4187_RS19000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4187_RS19005	COG0768	penicillin binding
E4187_RS19010	COG3116	cell division
E4187_RS19015	COG0275	rRNA processing
E4187_RS19020	COG2001	Belongs to the MraZ family
E4187_RS19030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4187_RS19035	COG3107	peptidoglycan biosynthetic process
E4187_RS19040	COG0792	nuclease activity
E4187_RS19045	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4187_RS19050	COG2823	Periplasmic or secreted lipoprotein
E4187_RS19055	COG2969	positive regulation of protein catabolic process
E4187_RS19060	COG0625	glutathione transferase activity
E4187_RS19065	COG2857	Cytochrome c1
E4187_RS19070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4187_RS19075	COG0723	plastoquinol--plastocyanin reductase activity
E4187_RS19080	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4187_RS19085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4187_RS19090	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4187_RS19100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4187_RS19105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4187_RS19115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4187_RS19120	COG1660	Displays ATPase and GTPase activities
E4187_RS19125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4187_RS19140	COG1137	ATPase activity
E4187_RS19145	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4187_RS19150	COG3117	lipopolysaccharide transmembrane transporter activity
E4187_RS19155	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4187_RS19160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4187_RS19160	COG0517	IMP dehydrogenase activity
E4187_RS19165	COG1127	ABC transporter
E4187_RS19170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4187_RS19175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4187_RS19180	COG2854	intermembrane phospholipid transfer
E4187_RS19190	COG5007	Belongs to the BolA IbaG family
E4187_RS19195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4187_RS19200	COG0312	modulator of DNA gyrase
E4187_RS19205	COG3028	Belongs to the UPF0307 family
E4187_RS19215	COG2926	Belongs to the UPF0265 family
E4187_RS19245	COG1396	sequence-specific DNA binding
E4187_RS19250	COG3135	benzoate transporter
E4187_RS19260	COG1522	sequence-specific DNA binding
E4187_RS19270	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E4187_RS19280	COG1546	Belongs to the CinA family
E4187_RS19280	COG1058	Belongs to the CinA family
E4187_RS19285	COG1988	membrane-bound metal-dependent
E4187_RS19295	COG0561	phosphatase activity
E4187_RS19300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4187_RS19310	COG1011	Hydrolase
E4187_RS19325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4187_RS19330	COG0019	diaminopimelate decarboxylase activity
E4187_RS19340	COG1965	Belongs to the frataxin family
E4187_RS19345	COG0400	carboxylic ester hydrolase activity
E4187_RS19350	COG3072	Adenylate cyclase
E4187_RS19355	COG0181	hydroxymethylbilane synthase activity
E4187_RS19365	COG2959	enzyme of heme biosynthesis
E4187_RS19370	COG3071	HemY protein
E4187_RS19380	COG1494	fructose-1,6-bisphosphatase
E4187_RS19390	COG1247	-acetyltransferase
E4187_RS19410	COG0456	acetyltransferase
E4187_RS19415	COG1733	regulation of RNA biosynthetic process
E4187_RS19435	COG3932	Exopolysaccharide synthesis, ExoD
E4187_RS19440	COG3706	GGDEF domain
E4187_RS19450	COG0110	maltose O-acetyltransferase activity
E4187_RS19460	COG1943	Transposase
E4187_RS19465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4187_RS19470	COG2022	thiamine diphosphate biosynthetic process
E4187_RS19480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4187_RS19485	COG0352	thiamine-phosphate diphosphorylase activity
E4187_RS19490	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E4187_RS19510	COG0745	RESPONSE REGULATOR receiver
E4187_RS19515	COG0642	Histidine kinase
E4187_RS19520	COG0189	ligase activity
E4187_RS19550	COG2321	neutral zinc metallopeptidase
E4187_RS19560	COG0477	Major facilitator Superfamily
E4187_RS19575	COG0312	modulator of DNA gyrase
E4187_RS19580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4187_RS19585	COG3164	Protein of unknown function
E4187_RS19590	COG1530	ribonuclease E activity
E4187_RS19595	COG0424	maF-like protein
E4187_RS19600	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4187_RS19605	COG1792	Involved in formation and maintenance of cell shape
E4187_RS19610	COG1077	Cell shape determining protein MreB Mrl
E4187_RS19655	COG1459	type II secretion system
E4187_RS19660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4187_RS19680	COG5433	transposase activity
E4187_RS19715	COG2200	EAL domain
E4187_RS19720	COG0387	Pfam Sodium calcium exchanger
E4187_RS19730	COG2986	histidine ammonia-lyase
E4187_RS19735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4187_RS19740	COG0010	Belongs to the arginase family
E4187_RS19745	COG1228	amidohydrolase
E4187_RS19750	COG2188	Transcriptional regulator
E4187_RS19755	COG0288	reversible hydration of carbon dioxide
E4187_RS19765	COG2177	Part of the ABC transporter FtsEX involved in
E4187_RS19770	COG2884	Cell division ATP-binding protein ftsE
E4187_RS19775	COG0552	protein localization to endoplasmic reticulum
E4187_RS19780	COG0742	ribosomal rna small subunit methyltransferase
E4187_RS19805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4187_RS19815	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4187_RS19825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4187_RS19835	COG2095	MarC family integral membrane protein
E4187_RS19845	COG1301	dicarboxylic acid transport
E4187_RS19870	COG3714	YhhN family
E4187_RS19890	COG1770	oligopeptidase
E4187_RS19905	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4187_RS19930	COG5433	transposase activity
E4187_RS19975	COG0203	ribosomal protein L17
E4187_RS19980	COG0202	RNA polymerase activity
E4187_RS19985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4187_RS19990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4187_RS19995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4187_RS20000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4187_RS20005	COG0201	protein transport
E4187_RS20010	COG0200	Binds to the 23S rRNA
E4187_RS20015	COG1841	ribosomal large subunit assembly
E4187_RS20020	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4187_RS20025	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4187_RS20030	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4187_RS20035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4187_RS20040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4187_RS20045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4187_RS20050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4187_RS20055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4187_RS20060	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4187_RS20065	COG0255	Belongs to the universal ribosomal protein uL29 family
E4187_RS20070	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4187_RS20075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4187_RS20080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4187_RS20085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4187_RS20090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4187_RS20095	COG0089	rRNA binding
E4187_RS20100	COG0088	Forms part of the polypeptide exit tunnel
E4187_RS20105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4187_RS20110	COG0051	transcription antitermination factor activity, RNA binding
E4187_RS20120	COG2205	protein histidine kinase activity
E4187_RS20125	COG0745	RESPONSE REGULATOR receiver
E4187_RS20155	COG3344	reverse transcriptase
E4187_RS20160	COG3385	transposase activity
E4187_RS20190	COG5433	transposase activity
E4187_RS20210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4187_RS20215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4187_RS20220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4187_RS20245	COG4584	PFAM Integrase catalytic
E4187_RS20250	COG1484	DNA-dependent DNA replication
E4187_RS20260	COG3706	GGDEF domain
E4187_RS20265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4187_RS20275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4187_RS20280	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4187_RS20285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4187_RS20330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4187_RS20340	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4187_RS20350	COG5433	transposase activity
E4187_RS20370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4187_RS20395	COG2183	response to ionizing radiation
E4187_RS20410	COG0596	Alpha beta hydrolase
E4187_RS20415	COG1040	competence protein
E4187_RS20420	COG0316	Belongs to the HesB IscA family
E4187_RS20420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4187_RS20425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4187_RS20430	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4187_RS20435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4187_RS20440	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4187_RS20445	COG4942	peptidase
E4187_RS20455	COG1609	Transcriptional regulator
E4187_RS20460	COG0800	Aldolase
E4187_RS20465	COG0129	dihydroxy-acid dehydratase activity
E4187_RS20470	COG3265	gluconokinase activity
E4187_RS20475	COG2610	gluconate transmembrane transporter activity
E4187_RS20480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4187_RS20490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4187_RS20500	COG0456	acetyltransferase
E4187_RS20510	COG1490	D-aminoacyl-tRNA deacylase activity
E4187_RS20515	COG1295	ribonuclease BN
E4187_RS20525	COG0174	glutamine synthetase
E4187_RS20535	COG3852	Histidine kinase
E4187_RS20545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4187_RS20550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4187_RS20560	COG3078	GTPase activator activity
E4187_RS20570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4187_RS20575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4187_RS20580	COG0408	coproporphyrinogen oxidase activity
E4187_RS20585	COG0009	L-threonylcarbamoyladenylate synthase
E4187_RS20590	COG0551	DNA topoisomerase type I activity
E4187_RS20595	COG2922	Belongs to the Smg family
E4187_RS20600	COG0758	DNA mediated transformation
E4187_RS20610	COG0242	peptide deformylase activity
E4187_RS20615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4187_RS20620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4187_RS20620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4187_RS20625	COG0569	domain protein
E4187_RS20630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4187_RS20635	COG1322	Protein conserved in bacteria
E4187_RS20655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4187_RS20665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4187_RS20665	COG0519	Catalyzes the synthesis of GMP from XMP
E4187_RS20680	COG1396	sequence-specific DNA binding
E4187_RS20685	COG1012	belongs to the aldehyde dehydrogenase family
E4187_RS20695	COG2962	Rard protein
E4187_RS20705	COG1280	lysine exporter protein (LysE YggA)
E4187_RS20710	COG2391	methyltransferase activity
E4187_RS20745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4187_RS20765	COG5433	transposase activity
E4187_RS20780	COG0210	DNA helicase
E4187_RS20825	COG0583	DNA-binding transcription factor activity
E4187_RS20850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4187_RS20855	COG0385	Bile acid
E4187_RS20860	COG0531	amino acid
E4187_RS20865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4187_RS20870	COG0531	amino acid
E4187_RS20875	COG2731	YhcH YjgK YiaL family protein
E4187_RS20880	COG3250	beta-galactosidase activity
E4187_RS20885	COG1609	Transcriptional regulator
E4187_RS20925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4187_RS20930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4187_RS20930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4187_RS20935	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4187_RS20940	COG3074	FtsZ-dependent cytokinesis
E4187_RS20950	COG1045	serine acetyltransferase
E4187_RS20960	COG0745	RESPONSE REGULATOR receiver
E4187_RS20965	COG2205	protein histidine kinase activity
E4187_RS20970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4187_RS20975	COG0534	Mate efflux family protein
E4187_RS20990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4187_RS20995	COG2937	Belongs to the GPAT DAPAT family
E4187_RS21000	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4187_RS21005	COG3161	chorismate lyase activity
E4187_RS21010	COG1580	Controls the rotational direction of flagella during chemotaxis
E4187_RS21025	COG0604	alcohol dehydrogenase
E4187_RS21045	COG3307	-O-antigen
E4187_RS21050	COG0438	transferase activity, transferring glycosyl groups
E4187_RS21055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4187_RS21070	COG1063	alcohol dehydrogenase
E4187_RS21085	COG0210	DNA helicase
E4187_RS21090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4187_RS21095	COG2166	iron-sulfur cluster assembly
E4187_RS21100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4187_RS21135	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4187_RS21140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4187_RS21145	COG1739	Uncharacterized protein family UPF0029
E4187_RS21150	COG0006	proline dipeptidase activity
E4187_RS21155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4187_RS21160	COG1024	Enoyl-CoA hydratase
E4187_RS21160	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4187_RS21165	COG0183	Belongs to the thiolase family
E4187_RS21170	COG0745	RESPONSE REGULATOR receiver
E4187_RS21180	COG1653	transport
E4187_RS21190	COG0425	Belongs to the sulfur carrier protein TusA family
E4187_RS21195	COG0251	oxidation-reduction process
E4187_RS21200	COG2885	chlorophyll binding
E4187_RS21225	COG2818	Glycosylase
E4187_RS21230	COG0752	glycyl-tRNA synthetase alpha subunit
E4187_RS21235	COG0751	glycine-tRNA ligase activity
E4187_RS21270	COG0814	amino acid
E4187_RS21275	COG0814	amino acid
E4187_RS21280	COG3033	Beta-eliminating lyase
E4187_RS21290	COG0348	domain, Protein
E4187_RS21300	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4187_RS21305	COG0426	domain, Protein
E4187_RS21305	COG1773	rubredoxin
E4187_RS21310	COG3604	Transcriptional regulator
E4187_RS21315	COG1609	Transcriptional regulator
E4187_RS21355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4187_RS21370	COG2960	long-chain fatty acid transporting porin activity
E4187_RS21380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4187_RS21395	COG3118	belongs to the thioredoxin family
E4187_RS21400	COG0513	Belongs to the DEAD box helicase family
E4187_RS21405	COG0248	Ppx GppA phosphatase
E4187_RS21420	COG0742	ribosomal rna small subunit methyltransferase
E4187_RS21440	COG0084	hydrolase, TatD family'
E4187_RS21445	COG0805	protein transport
E4187_RS21450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4187_RS21455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4187_RS21460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4187_RS21465	COG3165	ubiquinone biosynthetic process from chorismate
E4187_RS21470	COG2226	methyltransferase
E4187_RS21475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4187_RS21480	COG0402	S-adenosylhomocysteine deaminase activity
E4187_RS21485	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4187_RS21520	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4187_RS21525	COG0848	biopolymer transport protein
E4187_RS21530	COG0811	peptide transport
E4187_RS21535	COG0811	peptide transport
E4187_RS21545	COG2771	luxR family
E4187_RS21555	COG1111	helicase
E4187_RS21555	COG1205	dead DEAH box helicase
E4187_RS21570	COG3039	Transposase
E4187_RS21600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4187_RS21605	COG1349	DNA-binding transcription factor activity
E4187_RS21610	COG0745	RESPONSE REGULATOR receiver
E4187_RS21615	COG2205	protein histidine kinase activity
E4187_RS21630	COG4452	Inner membrane protein CreD
E4187_RS21635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4187_RS21640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4187_RS21645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4187_RS21650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4187_RS21655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4187_RS21660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4187_RS21665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4187_RS21675	COG0356	it plays a direct role in the translocation of protons across the membrane
E4187_RS21685	COG1475	DNA binding
E4187_RS21690	COG1192	Involved in chromosome partitioning
E4187_RS21695	COG0357	Ribosomal RNA small subunit methyltransferase G
E4187_RS21700	COG0445	tRNA wobble uridine modification
E4187_RS21705	COG0716	FMN binding
E4187_RS21710	COG4774	siderophore transport
E4187_RS21715	COG4615	Cyclic peptide transporter
E4187_RS21720	COG1120	ATPase activity
E4187_RS21725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4187_RS21730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4187_RS21740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4187_RS21745	COG0706	membrane insertase activity
E4187_RS21750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4187_RS21755	COG0594	ribonuclease P activity
E4187_RS21760	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4187_RS22060	COG2974	May be involved in recombination
E4187_RS22075	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4187_RS22100	COG1192	Involved in chromosome partitioning
E4187_RS22160	COG4676	Protein conserved in bacteria
E4187_RS22230	COG0681	Belongs to the peptidase S26 family
E4187_RS22305	COG1988	membrane-bound metal-dependent
E4187_RS22605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4187_RS22635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease