locus-tag	class	description
E4188_RS00015	ENOG4107QPH	glycogen) synthase
E4188_RS00020	ENOG4105CG5	Glycosyl transferase (Group 1
E4188_RS00055	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
E4188_RS00060	ENOG4105ESV	Glycosyl transferase, family 4
E4188_RS00070	ENOG4105ESV	Glycosyl transferase, family 4
E4188_RS00115	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
E4188_RS00125	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
E4188_RS00130	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
E4188_RS00140	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
E4188_RS00155	ENOG4106KNT	transcriptional regulator
E4188_RS00160	ENOG4105CA9	Pyruvate kinase
E4188_RS00170	ENOG4105BZS	acriflavin resistance protein
E4188_RS00175	ENOG4107QPN	acyl-Coa dehydrogenase
E4188_RS00185	ENOG4107SSZ	Phosphatase
E4188_RS00215	ENOG410600T	transposase
E4188_RS00225	ENOG4105F2I	Transposase
E4188_RS00250	ENOG4105VUH	addiction module killer protein
E4188_RS00270	ENOG4105F5W	AtP-binding protein
E4188_RS00275	ENOG4105D70	Integrase catalytic subunit
E4188_RS00290	ENOG4105F2I	Transposase
E4188_RS00305	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E4188_RS00310	ENOG4105BZS	acriflavin resistance protein
E4188_RS00315	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
E4188_RS00320	ENOG4108IG5	Transcriptional regulator
E4188_RS00335	ENOG4105C29	acyl-CoA thioesterase
E4188_RS00340	ENOG4105FE9	pseudouridine synthase
E4188_RS00345	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
E4188_RS00355	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
E4188_RS00360	ENOG4105DB7	PHP domain protein
E4188_RS00365	ENOG4105CRQ	synthase (Component I)
E4188_RS00370	ENOG4108EFP	Anthranilate synthase component II
E4188_RS00375	ENOG4108I0Q	anthranilate phosphoribosyltransferase
E4188_RS00380	ENOG4105DK0	Indole-3-glycerol phosphate synthase
E4188_RS00385	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
E4188_RS00390	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
E4188_RS00395	ENOG4105I03	Flagellin
E4188_RS00400	ENOG410600T	transposase
E4188_RS00405	ENOG4105I03	Flagellin
E4188_RS00415	ENOG4105CAF	HipA N-terminal domain protein
E4188_RS00435	ENOG4105JQN	Transcriptional regulator
E4188_RS00450	ENOG4105KCV	RNA signal recognition particle 4.5S RNA
E4188_RS00455	ENOG4107RDB	Major Facilitator
E4188_RS00465	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
E4188_RS00470	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
E4188_RS00475	ENOG4105CCU	oxidase (Subunit III)
E4188_RS00480	ENOG4105BZ9	Cytochrome C oxidase, subunit I
E4188_RS00485	ENOG4105E2S	oxidase) subunit II
E4188_RS00490	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
E4188_RS00495	ENOG4105CC0	LysR family Transcriptional regulator
E4188_RS00535	ENOG4105VN1	Heat shock protein
E4188_RS00560	ENOG4105CGK	Exodeoxyribonuclease III
E4188_RS00570	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
E4188_RS00575	ENOG4108IJF	Heavy metal efflux pump, CzcA
E4188_RS00590	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
E4188_RS00595	ENOG4105BZU	Histidine kinase
E4188_RS00640	ENOG4105WBN	Transcriptional regulator (LacI family
E4188_RS00655	ENOG4105D7K	pfkb domain protein
E4188_RS00665	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E4188_RS00670	ENOG4105CFG	Acts as a chaperone (By similarity)
E4188_RS00675	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4188_RS00680	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
E4188_RS00690	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
E4188_RS00695	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
E4188_RS00705	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
E4188_RS00710	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
E4188_RS00715	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E4188_RS00720	ENOG4105Q26	Siderophore-interacting protein
E4188_RS00735	ENOG4105W8I	Transcriptional regulator
E4188_RS00745	ENOG4105BZC	d-serine deaminase
E4188_RS00755	ENOG4108HMX	isocitrate dehydrogenase (NADP)
E4188_RS00760	ENOG4106R3P	AraC family transcriptional regulator
E4188_RS00765	ENOG4105EIP	mannose-6-phosphate isomerase
E4188_RS00770	ENOG4105P66	Membrane
E4188_RS00785	ENOG4107VGF	ig domain protein group 2 domain protein
E4188_RS00800	ENOG4107NQ8	LysR family Transcriptional regulator
E4188_RS00805	ENOG4105D70	Integrase catalytic subunit
E4188_RS00810	ENOG4105F5W	AtP-binding protein
E4188_RS00835	ENOG4105DM4	PTS System
E4188_RS00840	ENOG4105CXY	transporter
E4188_RS00845	ENOG4108YRF	PTS System
E4188_RS00855	ENOG4108R99	pseudouridine synthase
E4188_RS00865	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
E4188_RS00870	ENOG41075W9	High frequency lysogenization protein HflD homolog
E4188_RS00875	ENOG4107QTF	adenylosuccinate lyase
E4188_RS00880	ENOG4105EZE	Cupin 4 family protein
E4188_RS00885	ENOG4105CA9	Pyruvate kinase
E4188_RS00890	ENOG4105EGS	Mechanosensitive ion channel
E4188_RS00900	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
E4188_RS00915	ENOG4105C2W	permease
E4188_RS00920	ENOG4107R1I	NAD-dependent malic enzyme
E4188_RS00925	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
E4188_RS00930	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
E4188_RS00935	ENOG4108ESY	Metal dependent phosphohydrolase
E4188_RS00945	ENOG4107SDU	Methyl-accepting chemotaxis
E4188_RS00965	ENOG4105E18	UPF0276 protein
E4188_RS00995	ENOG4108VSZ	Inherit from COG: ketosteroid isomerase-like protein
E4188_RS01000	ENOG4105D98	threonine synthase
E4188_RS01005	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
E4188_RS01015	ENOG4106FVC	RNA methyltransferase
E4188_RS01020	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
E4188_RS01025	ENOG4107R11	Transcriptional regulator
E4188_RS01030	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
E4188_RS01060	ENOG4105M2J	Glutaredoxin
E4188_RS01065	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
E4188_RS01070	ENOG410903C	(LipO)protein
E4188_RS01080	ENOG4105KWW	Biogenesis protein
E4188_RS01085	ENOG4107QX9	Thiol disulfide interChange protein
E4188_RS01090	ENOG4105DA4	cytochrome c-type biogenesis protein
E4188_RS01095	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
E4188_RS01100	ENOG4105X3C	heme exporter protein
E4188_RS01105	ENOG41060IM	Heme exporter protein
E4188_RS01110	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
E4188_RS01125	ENOG4108V3W	Chemotaxis protein, CheW
E4188_RS01130	ENOG4105CVR	type I restriction-modification system
E4188_RS01155	ENOG4107QJE	Chromosome Partitioning Protein
E4188_RS01160	ENOG4108SEK	ompa motb domain protein
E4188_RS01165	ENOG4105E14	MotA TolQ exbB proton channel
E4188_RS01170	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
E4188_RS01180	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
E4188_RS01185	ENOG4108VYJ	response regulator receiver protein
E4188_RS01190	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4188_RS01200	ENOG4105FZW	flagellar biosynthesis regulator FlhF
E4188_RS01205	ENOG4105D7B	Flagellar biosynthesis protein flha
E4188_RS01210	ENOG4105D00	flagellar biosynthetic protein flhB
E4188_RS01220	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
E4188_RS01225	ENOG4105VS8	Flagellar biosynthetic protein fliq
E4188_RS01230	ENOG4105CN7	Flagellar biosynthetic protein FliP
E4188_RS01235	ENOG4105CN7	Flagellar biosynthetic protein FliP
E4188_RS01240	ENOG4105VTB	flagellar biosynthesis protein fliO
E4188_RS01245	ENOG4105DD5	Flagellar motor switch protein
E4188_RS01250	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
E4188_RS01270	ENOG4108JIR	Flagellum-specific ATP synthase
E4188_RS01280	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
E4188_RS01285	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
E4188_RS01300	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
E4188_RS01315	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E4188_RS01325	ENOG4108JQ7	(ABC) transporter
E4188_RS01335	ENOG4105RD7	BadF BadG BcrA BcrD
E4188_RS01340	ENOG4105E2D	ec 3.2.1.52
E4188_RS01345	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
E4188_RS01360	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
E4188_RS01365	ENOG4105EY2	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity)
E4188_RS01370	ENOG4105ERU	peptidase
E4188_RS01375	ENOG4105UBK	short-chain dehydrogenase reductase
E4188_RS01380	ENOG4105C5Q	Transcriptional regulator
E4188_RS01390	ENOG4105C87	Aminotransferase class I and II
E4188_RS01405	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
E4188_RS01410	ENOG4108V1U	phospholipid-binding protein
E4188_RS01420	ENOG4107WCA	isomerase
E4188_RS01425	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E4188_RS01430	ENOG4105DR5	peptidase
E4188_RS01435	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
E4188_RS01445	ENOG410600T	transposase
E4188_RS01480	ENOG4105CV1	Transketolase (EC 2.2.1.1)
E4188_RS01485	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
E4188_RS01490	ENOG4105GPY	SprT protein
E4188_RS01500	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
E4188_RS01505	ENOG4105D7Z	glutathione synthase
E4188_RS01525	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
E4188_RS01530	ENOG4105G2Y	Transcriptional regulator
E4188_RS01555	ENOG4105BZG	amino acid carrier protein
E4188_RS01560	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
E4188_RS01575	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
E4188_RS01580	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
E4188_RS01590	ENOG4105EQR	Transposase IS116 IS110 IS902
E4188_RS01605	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
E4188_RS01610	ENOG41063JG	Transcriptional regulator
E4188_RS01620	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
E4188_RS01625	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
E4188_RS01630	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
E4188_RS01635	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
E4188_RS01640	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
E4188_RS01650	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
E4188_RS01655	ENOG4105CGH	5'-nucleotidase
E4188_RS01660	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
E4188_RS01665	ENOG4105C3G	gtp-binding protein
E4188_RS01710	ENOG4107QWE	)-transporter
E4188_RS01715	ENOG4105N5Z	UPF0267 protein
E4188_RS01735	ENOG4107VXZ	Hydrolase
E4188_RS01745	ENOG4105C26	Dehydrogenase
E4188_RS01750	ENOG4105F4X	arginine
E4188_RS01755	ENOG4105C8Y	Acetylornithine aminotransferase
E4188_RS01770	ENOG4105C31	Tryptophanyl-tRNA synthetase
E4188_RS01775	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
E4188_RS01780	ENOG4105DJV	ribulose-phosphate 3-epimerase
E4188_RS01785	ENOG4105DFE	Dna adenine methylase
E4188_RS01795	ENOG4105D49	3-dehydroquinate synthase
E4188_RS01800	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
E4188_RS01805	ENOG4105E4G	Type IV pilus
E4188_RS01835	ENOG4108JQC	penicillin-binding protein 1A
E4188_RS01840	ENOG4105C5Q	Transcriptional regulator
E4188_RS01855	ENOG4105EJC	lysr family transcriptional regulator
E4188_RS01870	ENOG4108VEV	chaperone
E4188_RS01880	ENOG4108VEV	chaperone
E4188_RS01885	ENOG4105DR5	peptidase
E4188_RS01895	ENOG4105EGS	Mechanosensitive ion channel
E4188_RS01900	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
E4188_RS01905	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS01915	ENOG4105E33	succinate dehydrogenase
E4188_RS01920	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
E4188_RS01925	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
E4188_RS01930	ENOG4105T0Z	Conserved Protein
E4188_RS01935	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
E4188_RS01945	ENOG4108IQE	Amp-dependent synthetase and ligase
E4188_RS01955	ENOG4108IXY	short-chain dehydrogenase reductase
E4188_RS01965	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
E4188_RS01970	ENOG4105DHQ	Histidine kinase
E4188_RS01980	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E4188_RS01990	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
E4188_RS01995	ENOG4108R5S	membrane
E4188_RS02005	ENOG4105C5I	Dehydrogenase
E4188_RS02015	ENOG4108KHX	Diguanylate cyclase
E4188_RS02025	ENOG4105BZU	Histidine kinase
E4188_RS02030	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
E4188_RS02040	ENOG4105F04	LysR family Transcriptional regulator
E4188_RS02045	ENOG4105VEQ	Cold shock protein
E4188_RS02050	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
E4188_RS02055	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
E4188_RS02060	ENOG4105C9A	Phoh family
E4188_RS02065	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
E4188_RS02070	ENOG4108JU5	Magnesium and cobalt efflux protein
E4188_RS02075	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
E4188_RS02080	ENOG4107PAI	alpha helical protein
E4188_RS02085	ENOG4105C8T	Leucyl-tRNA synthetase
E4188_RS02100	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
E4188_RS02105	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
E4188_RS02110	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
E4188_RS02115	ENOG4105CJN	penicillin-binding protein
E4188_RS02120	ENOG4105CNI	cell division protein FtsW
E4188_RS02125	ENOG4105CVE	Lytic murein transglycosylase
E4188_RS02130	ENOG4105K6T	rare lipoprotein A
E4188_RS02135	ENOG4105DZ1	carboxypeptidase
E4188_RS02140	ENOG4108Z43	UPF0250 protein
E4188_RS02145	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
E4188_RS02150	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
E4188_RS02160	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4188_RS02170	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
E4188_RS02185	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
E4188_RS02195	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4188_RS02200	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
E4188_RS02210	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
E4188_RS02225	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
E4188_RS02230	ENOG4105CFP	Peptidase U32
E4188_RS02235	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
E4188_RS02250	ENOG41090EX	DsrE family
E4188_RS02255	ENOG4105E5W	Transporter
E4188_RS02260	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
E4188_RS02265	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
E4188_RS02270	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
E4188_RS02275	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
E4188_RS02280	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
E4188_RS02285	ENOG4105CHV	Transcription elongation factor NusA
E4188_RS02290	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
E4188_RS02305	ENOG4105NTZ	Preprotein translocase subunit SecG
E4188_RS02310	ENOG4105CP7	Triose-phosphate isomerase
E4188_RS02315	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
E4188_RS02320	ENOG4105EEI	dihydropteroate synthase
E4188_RS02325	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
E4188_RS02330	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
E4188_RS02335	ENOG4105HBR	Rna-binding protein
E4188_RS02345	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
E4188_RS02350	ENOG4107XSU	flagellar motor protein motb
E4188_RS02355	ENOG4105E14	MotA TolQ exbB proton channel
E4188_RS02360	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E4188_RS02365	ENOG4105CTB	Polyprenyl synthetase
E4188_RS02370	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
E4188_RS02375	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E4188_RS02380	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E4188_RS02390	ENOG4108JQ6	ABC transporter
E4188_RS02395	ENOG4108ZAI	phosphatidylglycerophosphatase a
E4188_RS02400	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
E4188_RS02405	ENOG4107YIM	Involved in the transcription termination process (By similarity)
E4188_RS02410	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
E4188_RS02425	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
E4188_RS02430	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
E4188_RS02445	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
E4188_RS02455	ENOG4105BZU	Histidine kinase
E4188_RS02460	ENOG4108SV3	Tmao reductase system periplasmic protein tort
E4188_RS02470	ENOG4106WF9	DNA-binding transcriptional regulator TorR
E4188_RS02475	ENOG4105CUW	cytochrome C-TYPE protein
E4188_RS02480	ENOG4108EM1	reductase
E4188_RS02485	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
E4188_RS02505	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
E4188_RS02510	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
E4188_RS02515	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
E4188_RS02520	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
E4188_RS02525	ENOG4105RG0	Membrane
E4188_RS02530	ENOG4108IA2	Sodium pantothenate symporter
E4188_RS02535	ENOG4105CI1	PTS System
E4188_RS02540	ENOG4105HEI	LysR family (Transcriptional regulator
E4188_RS02545	ENOG4105CIS	alcohol dehydrogenase
E4188_RS02550	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
E4188_RS02560	ENOG41069NU	Nitroreductase
E4188_RS02565	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E4188_RS02570	ENOG4105D07	Signal peptide peptidase, SppA
E4188_RS02590	ENOG4105VUT	cytoplasmic protein
E4188_RS02595	ENOG4105HDK	L-asparaginase
E4188_RS02600	ENOG4105D6U	Sodium Glutamate Symporter
E4188_RS02610	ENOG4105BZU	Histidine kinase
E4188_RS02615	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS02625	ENOG4105CRK	lysyL-tRNA synthetase
E4188_RS02630	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
E4188_RS02635	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
E4188_RS02640	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
E4188_RS02645	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
E4188_RS02650	ENOG4105GIJ	Glycine betaine
E4188_RS02655	ENOG4108HQS	Glycine betaine
E4188_RS02660	ENOG4108IJ7	Glycine betaine
E4188_RS02670	ENOG4107XM3	UPF0442 protein
E4188_RS02675	ENOG4105DWK	Membrane
E4188_RS02685	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
E4188_RS02695	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E4188_RS02700	ENOG4105C2D	reductase
E4188_RS02765	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E4188_RS02810	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
E4188_RS02815	ENOG4105DD7	kinase (PfkB family
E4188_RS02820	ENOG4107QZF	nitrite reductase NADPH large subunit
E4188_RS02825	ENOG4107QZF	nitrite reductase NADPH large subunit
E4188_RS02830	ENOG4105D7T	ABC transporter
E4188_RS02835	ENOG4105DG7	nitrate ABC transporter
E4188_RS02880	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
E4188_RS02890	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
E4188_RS02895	ENOG4105V1F	Fermentation respiration switch protein
E4188_RS02900	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
E4188_RS02905	ENOG4105CIN	aminoacyl-histidine dipeptidase
E4188_RS02910	ENOG4108JQ7	(ABC) transporter
E4188_RS02925	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
E4188_RS02930	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
E4188_RS02955	ENOG4109015	Biopolymer transport protein exbD tolR
E4188_RS03000	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E4188_RS03005	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
E4188_RS03010	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS03020	ENOG4105VEQ	Cold shock protein
E4188_RS03060	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
E4188_RS03070	ENOG4105DJ4	phosphatidylserine decarboxylase
E4188_RS03075	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
E4188_RS03095	ENOG4108K01	transcriptional regulator
E4188_RS03105	ENOG4105BZU	Histidine kinase
E4188_RS03110	ENOG4105KQT	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity)
E4188_RS03125	ENOG4105CMR	udp-glucose 4-epimerase
E4188_RS03130	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
E4188_RS03135	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
E4188_RS03140	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
E4188_RS03145	ENOG4105W3H	MtN3 and saliva related transmembrane protein
E4188_RS03150	ENOG4105ETE	Transcriptional regulator (LacI family
E4188_RS03170	ENOG4105F2I	Transposase
E4188_RS03175	ENOG4108NUU	Transcriptional regulator
E4188_RS03200	ENOG4105BZ1	(ABC) transporter
E4188_RS03205	ENOG4105SUV	lipoprotein YgdR
E4188_RS03210	ENOG4107RM6	sulfurtransferase
E4188_RS03215	ENOG4105CSV	Glutaminase
E4188_RS03220	ENOG41090ED	Protein with unknown function (DUF469)
E4188_RS03225	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
E4188_RS03230	ENOG4105IIU	Aminopeptidase
E4188_RS03235	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
E4188_RS03240	ENOG4105BZU	Histidine kinase
E4188_RS03245	ENOG4105ECP	epimerase
E4188_RS03250	ENOG4105CV6	ABC transporter, permease
E4188_RS03255	ENOG4108I0Y	(ABC) transporter
E4188_RS03260	ENOG4108UJV	acyl-CoA thioesterase i
E4188_RS03270	ENOG4105FCK	Membrane
E4188_RS03275	ENOG41080XP	Cbs domain
E4188_RS03280	ENOG4105C5H	ABC transporter
E4188_RS03290	ENOG4105D6S	protein involved in catabolism of external DNA
E4188_RS03320	ENOG4105F2I	Transposase
E4188_RS03340	ENOG4105CK7	Sodium proline symporter
E4188_RS03345	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
E4188_RS03350	ENOG4105CUY	Mechanosensitive ion channel
E4188_RS03360	ENOG4105XEP	YhcH YjgK YiaL family protein
E4188_RS03370	ENOG4105D9U	N-acetyltransferase
E4188_RS03390	ENOG4105EV4	Multidrug resistance protein mdtH
E4188_RS03400	ENOG4105D0C	transport protein
E4188_RS03405	ENOG4108UT2	hemolysin iii
E4188_RS03410	ENOG4105DY8	decarboxylase
E4188_RS03415	ENOG4107835	probably involved in intracellular septation (By similarity)
E4188_RS03420	ENOG4105K9H	YciI-like protein
E4188_RS03425	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
E4188_RS03430	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
E4188_RS03435	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
E4188_RS03440	ENOG4105DUX	Transporter
E4188_RS03445	ENOG4105I93	response regulator
E4188_RS03475	ENOG4107V40	secretion protein, HlyD family
E4188_RS03505	ENOG4105CVR	type I restriction-modification system
E4188_RS03515	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
E4188_RS03550	ENOG4105F5W	AtP-binding protein
E4188_RS03555	ENOG4105D70	Integrase catalytic subunit
E4188_RS03575	ENOG4105BZU	Histidine kinase
E4188_RS03580	ENOG4105BZU	Histidine kinase
E4188_RS03600	ENOG4105EQR	Transposase IS116 IS110 IS902
E4188_RS03615	ENOG410600T	transposase
E4188_RS03630	ENOG4105BZU	Histidine kinase
E4188_RS03640	ENOG4105MAW	Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles
E4188_RS03690	ENOG4105W5Q	DNA repair protein (RadC
E4188_RS03740	ENOG410679B	prophage CP4-57 regulatory protein alpA
E4188_RS03755	ENOG4108YX2	DNA-binding protein
E4188_RS03775	ENOG4108NIW	Leucine export protein LeuE
E4188_RS03800	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
E4188_RS03810	ENOG4105CMQ	Chloride channel
E4188_RS03815	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
E4188_RS03830	ENOG41076MN	Phosphoesterase, PA-phosphatase related
E4188_RS03840	ENOG4105EGI	Transcriptional regulator
E4188_RS03845	ENOG41090TI	Catalyzes the excretion of spermidine (By similarity)
E4188_RS03850	ENOG4108ZBZ	Catalyzes the excretion of spermidine (By similarity)
E4188_RS03860	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
E4188_RS03865	ENOG4105BZ4	penicillin-binding protein
E4188_RS03870	ENOG4105CQ7	ATP-dependent helicase
E4188_RS03875	ENOG4108784	2'-5' rna ligase
E4188_RS03880	ENOG4105PW4	Sugar fermentation stimulation protein homolog
E4188_RS03890	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
E4188_RS03895	ENOG4105DJ0	Poly(A) Polymerase
E4188_RS03900	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4188_RS03905	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
E4188_RS03910	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
E4188_RS03920	ENOG4105E3A	(ABC) transporter
E4188_RS03925	ENOG4105DA5	(ABC) transporter
E4188_RS03930	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
E4188_RS03935	ENOG410630P	Transcriptional regulator
E4188_RS03940	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
E4188_RS03945	ENOG4105DFU	Cell wall formation (By similarity)
E4188_RS03950	ENOG4105F0N	pyrophosphate phospho-hydrolase
E4188_RS03965	ENOG4108UUE	Transcriptional regulator
E4188_RS03980	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E4188_RS04010	ENOG4105F2I	Transposase
E4188_RS04020	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
E4188_RS04030	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
E4188_RS04035	ENOG4105C11	sulfate adenylyltransferase), subunit 2
E4188_RS04040	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
E4188_RS04045	ENOG4107QX8	SPFH domain, Band 7 family protein
E4188_RS04050	ENOG4105G5H	Membrane
E4188_RS04060	ENOG4105D9R	oxidoreductase
E4188_RS04070	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
E4188_RS04075	ENOG4105CSA	Coproporphyrinogen iii oxidase
E4188_RS04095	ENOG4105DC1	bifunctional purine biosynthesis protein purh
E4188_RS04100	ENOG4105C12	Phosphoribosylglycinamide synthetase
E4188_RS04125	ENOG4105D70	Integrase catalytic subunit
E4188_RS04130	ENOG4105F5W	AtP-binding protein
E4188_RS04140	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4188_RS04145	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
E4188_RS04150	ENOG4105KTH	gatB Yqey
E4188_RS04155	ENOG4105VCC	30S ribosomal protein S21
E4188_RS04160	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E4188_RS04170	ENOG4108K5P	(LipO)protein
E4188_RS04175	ENOG4108UM1	dedA family
E4188_RS04180	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
E4188_RS04185	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
E4188_RS04190	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
E4188_RS04195	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
E4188_RS04200	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
E4188_RS04205	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
E4188_RS04210	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
E4188_RS04215	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
E4188_RS04220	ENOG4105DXN	mazG family
E4188_RS04225	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E4188_RS04230	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E4188_RS04235	ENOG4105BZU	Histidine kinase
E4188_RS04240	ENOG4108W15	Protein of unknown function (DUF1456)
E4188_RS04245	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
E4188_RS04250	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
E4188_RS04255	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
E4188_RS04270	ENOG4105C3F	Signal peptidase i
E4188_RS04275	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
E4188_RS04295	ENOG4105EMN	RNA polymerase sigma factor
E4188_RS04300	ENOG4108IYU	L-aspartate oxidase
E4188_RS04335	ENOG4105VF7	tolerance protein
E4188_RS04340	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
E4188_RS04350	ENOG4105CJP	fad dependent oxidoreductase
E4188_RS04355	ENOG4105D2N	Aldolase
E4188_RS04360	ENOG4105BZA	Phosphoglycerate kinase
E4188_RS04365	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
E4188_RS04370	ENOG4105DKQ	ROK family
E4188_RS04375	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
E4188_RS04380	ENOG4105E09	nadh pyrophosphatase
E4188_RS04385	ENOG4106MWK	domain protein
E4188_RS04390	ENOG4105EYW	Ion transport protein
E4188_RS04395	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS04405	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
E4188_RS04415	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
E4188_RS04420	ENOG4108GAE	asmA family
E4188_RS04430	ENOG4107PU6	Membrane
E4188_RS04435	ENOG4108UW5	maltose o-acetyltransferase
E4188_RS04450	ENOG4105F2I	Transposase
E4188_RS04460	ENOG4105CH7	arginosuccinase
E4188_RS04465	ENOG4105CDH	Citrulline--aspartate ligase
E4188_RS04475	ENOG4105CAS	nag kinase
E4188_RS04480	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
E4188_RS04490	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
E4188_RS04495	ENOG4105BZU	Histidine kinase
E4188_RS04500	ENOG4108Z66	YbaK ebsC protein
E4188_RS04530	ENOG4105CMU	LysR family (Transcriptional regulator
E4188_RS04540	ENOG41067MG	lrgb family
E4188_RS04545	ENOG4105CFH	Aspartokinase
E4188_RS04550	ENOG4105C28	cystathionine
E4188_RS04555	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
E4188_RS04565	ENOG4108Z7R	Chaperone CsaA
E4188_RS04570	ENOG4105C44	Serine transporter
E4188_RS04575	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
E4188_RS04580	ENOG4107RK2	ADP-ribose diphosphatase NudE
E4188_RS04585	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
E4188_RS04590	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
E4188_RS04595	ENOG4108UDW	Transcriptional regulator, luxr family
E4188_RS04640	ENOG4108VAU	general secretion pathway protein G
E4188_RS04645	ENOG4105D7Q	type ii secretion system
E4188_RS04650	ENOG4107QHF	type ii secretion system protein e
E4188_RS04655	ENOG4105GVR	general secretion pathway protein D
E4188_RS04665	ENOG4105VEJ	Heat shock protein
E4188_RS04670	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
E4188_RS04675	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
E4188_RS04695	ENOG4108XTF	Outer Membrane Lipoprotein
E4188_RS04705	ENOG4107IX6	phosphate transport regulator
E4188_RS04710	ENOG4105CJ3	phosphate transporter
E4188_RS04715	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
E4188_RS04730	ENOG4105CEN	a g-specific adenine glycosylase
E4188_RS04735	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
E4188_RS04740	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
E4188_RS04760	ENOG4108Q2G	(LipO)protein
E4188_RS04765	ENOG4105DY2	Paraquat-inducible protein b
E4188_RS04775	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
E4188_RS04780	ENOG4107VXZ	Hydrolase
E4188_RS04790	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
E4188_RS04795	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
E4188_RS04800	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
E4188_RS04805	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
E4188_RS04845	ENOG4105DFD	Na H antiporter
E4188_RS04850	ENOG4108M0I	Transcriptional regulator
E4188_RS04855	ENOG4107TYH	extracellular solute-binding protein family 1
E4188_RS04860	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E4188_RS04865	ENOG4105D81	ABC transporter, permease
E4188_RS04870	ENOG4105NRK	Binding-protein-dependent transport systems, inner membrane component
E4188_RS04875	ENOG4105C26	Dehydrogenase
E4188_RS04880	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
E4188_RS04885	ENOG4107VFP	cytochrome oxidase assembly
E4188_RS04905	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
E4188_RS04910	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
E4188_RS04915	ENOG4105BZ9	Cytochrome C oxidase, subunit I
E4188_RS04925	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
E4188_RS04940	ENOG4108UQY	Iron-storage protein
E4188_RS04945	ENOG4108Z5K	methylglyoxal synthase
E4188_RS04960	ENOG4105HDK	L-asparaginase
E4188_RS04970	ENOG4105DDV	Transcriptional regulator (LacI family
E4188_RS04980	ENOG4105DKQ	ROK family
E4188_RS04985	ENOG4105VCP	PTS System
E4188_RS04990	ENOG4105CS2	ec 3.2.1.21
E4188_RS04995	ENOG4105CK1	PTS System
E4188_RS05000	ENOG4105VZJ	PTS System
E4188_RS05005	ENOG4105CK1	PTS System
E4188_RS05015	ENOG4105D4X	repressor
E4188_RS05020	ENOG4105C5Y	PTS System
E4188_RS05025	ENOG4105CG3	alpha amylase, catalytic region
E4188_RS05030	ENOG4108UW5	maltose o-acetyltransferase
E4188_RS05040	ENOG4107AQZ	Membrane
E4188_RS05065	ENOG4105UYK	outer membrane protein a
E4188_RS05090	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
E4188_RS05095	ENOG4107ZVW	dihydroneopterin aldolase
E4188_RS05100	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4188_RS05110	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
E4188_RS05115	ENOG4105CKI	cobalamin synthesis protein
E4188_RS05125	ENOG4105E82	cytochrome subunit of dehydrogenase
E4188_RS05130	ENOG4108MGI	Transcriptional regulator
E4188_RS05135	ENOG4105BZU	Histidine kinase
E4188_RS05140	ENOG4107QIJ	Aconitate hydratase 2
E4188_RS05145	ENOG4105D78	K07001 NTE family protein
E4188_RS05150	ENOG41069D7	Methyl-accepting chemotaxis
E4188_RS05165	ENOG4107QN2	dihydrolipoyl dehydrogenase
E4188_RS05170	ENOG4107QSN	dihydrolipoamide acetyltransferase
E4188_RS05175	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
E4188_RS05180	ENOG41073TP	transcriptional regulator
E4188_RS05195	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
E4188_RS05215	ENOG4107QHF	type ii secretion system protein e
E4188_RS05220	ENOG4105D7Q	type ii secretion system
E4188_RS05225	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
E4188_RS05235	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
E4188_RS05240	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
E4188_RS05250	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
E4188_RS05260	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E4188_RS05265	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
E4188_RS05270	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
E4188_RS05275	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
E4188_RS05280	ENOG4105DFU	Cell wall formation (By similarity)
E4188_RS05285	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
E4188_RS05290	ENOG4105CNI	cell division protein FtsW
E4188_RS05295	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
E4188_RS05300	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
E4188_RS05305	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
E4188_RS05310	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
E4188_RS05315	ENOG4105CJN	penicillin-binding protein
E4188_RS05320	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
E4188_RS05325	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
E4188_RS05330	ENOG4108V6E	Cell division protein mraZ
E4188_RS05340	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
E4188_RS05345	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
E4188_RS05350	ENOG41082RQ	UPF0102 protein
E4188_RS05355	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
E4188_RS05360	ENOG4105W4M	Transport-associated protein
E4188_RS05365	ENOG4105KB2	stringent starvation protein b
E4188_RS05370	ENOG4107MKT	Stringent starvation protein a
E4188_RS05375	ENOG4105EIX	cytochrome c1
E4188_RS05380	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
E4188_RS05385	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
E4188_RS05390	ENOG4108UJD	30S ribosomal protein S9
E4188_RS05395	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
E4188_RS05400	ENOG4105D6Z	AFG1 family ATPase
E4188_RS05410	ENOG4105C0H	protease
E4188_RS05415	ENOG4105C0H	protease
E4188_RS05425	ENOG41080Z8	PHOSPHOCARRIER protein
E4188_RS05430	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
E4188_RS05435	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
E4188_RS05440	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
E4188_RS05445	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4188_RS05450	ENOG4108IUZ	ABC transporter
E4188_RS05455	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
E4188_RS05460	ENOG4108P1K	Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity)
E4188_RS05470	ENOG4105C2X	Arabinose 5-phosphate isomerase
E4188_RS05475	ENOG4105DHJ	ABC, transporter
E4188_RS05480	ENOG4105CY3	ABC transporter, permease
E4188_RS05485	ENOG4107PE3	Mammalian cell entry related domain protein
E4188_RS05490	ENOG4105E3I	toluene tolerance
E4188_RS05500	ENOG4105VFK	BolA family
E4188_RS05505	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
E4188_RS05510	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
E4188_RS05515	ENOG4105N42	UPF0307 protein
E4188_RS05525	ENOG41090HJ	UPF0265 protein
E4188_RS05555	ENOG4108JCI	Transcriptional regulator
E4188_RS05560	ENOG4105DKK	Benzoate
E4188_RS05570	ENOG4108YXU	transcriptional regulator AsnC family
E4188_RS05580	ENOG4105CVG	Homoserine O-transsuccinylase
E4188_RS05590	ENOG4108I62	cina-like protein
E4188_RS05595	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
E4188_RS05605	ENOG410667J	hydrolase
E4188_RS05610	ENOG4108Z86	Glutamine amidotransferase
E4188_RS05620	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
E4188_RS05625	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4188_RS05635	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
E4188_RS05640	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
E4188_RS05650	ENOG4105XQ6	frataxin-like protein
E4188_RS05655	ENOG4106CJB	Phospholipase Carboxylesterase
E4188_RS05660	ENOG4107T0K	Adenylate cyclase
E4188_RS05665	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
E4188_RS05670	ENOG41076E6	Uroporphyrinogen-III Synthase
E4188_RS05675	ENOG4105ECF	c-methyltransferase
E4188_RS05680	ENOG410601J	HemY protein
E4188_RS05685	ENOG4105KRS	Proteinase inhibitor
E4188_RS05690	ENOG4105CBT	Fructose-1,6-bisphosphatase
E4188_RS05695	ENOG4105FCK	Membrane
E4188_RS05700	ENOG4108Z7F	N-acetyltransferase
E4188_RS05720	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
E4188_RS05725	ENOG4105KVH	Transcriptional regulator
E4188_RS05730	ENOG4105N0V	mono-oxygenase ydhR
E4188_RS05745	ENOG4108TPP	exopolysaccharide synthesis
E4188_RS05750	ENOG4105BZU	Histidine kinase
E4188_RS05755	ENOG4108WEF	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity)
E4188_RS05760	ENOG4105EQK	-acetyltransferase
E4188_RS05770	ENOG4108UK5	Transposase
E4188_RS05775	ENOG4105D41	biosynthesis protein thiH
E4188_RS05780	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
E4188_RS05790	ENOG4105D06	uba thif-type nad fad binding protein
E4188_RS05795	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
E4188_RS05800	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
E4188_RS05805	ENOG4108MR7	Arylsulfotransferase
E4188_RS05820	ENOG4105ETX	regulatoR
E4188_RS05830	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
E4188_RS05835	ENOG4105C3R	Methionine synthase
E4188_RS05840	ENOG4105EEQ	Na H antiporter
E4188_RS05860	ENOG4105CGZ	zinc metallopeptidase
E4188_RS05870	ENOG4105CSH	Transporter
E4188_RS05885	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
E4188_RS05895	ENOG4105QD6	exported protein
E4188_RS05900	ENOG4105C03	ribonuclease
E4188_RS05905	ENOG4108Z03	MAF-like protein
E4188_RS05910	ENOG4105VQ7	Rod shape-determining protein MreD
E4188_RS05915	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
E4188_RS05945	ENOG4105X0D	Fimbrial protein
E4188_RS05950	ENOG4108VAU	general secretion pathway protein G
E4188_RS05965	ENOG4105D7Q	type ii secretion system
E4188_RS05970	ENOG4107QHF	type ii secretion system protein e
E4188_RS05990	ENOG410600T	transposase
E4188_RS06025	ENOG4107XTP	(EAL) domain protein
E4188_RS06030	ENOG4105EWV	Sodium calcium exchanger membrane region
E4188_RS06040	ENOG4105C84	Histidine ammonia-lyase
E4188_RS06045	ENOG4105CGP	Urocanate hydratase
E4188_RS06050	ENOG41088SP	formiminoglutamate hydrolase
E4188_RS06055	ENOG4105CI2	imidazolone-5-propionate hydrolase
E4188_RS06060	ENOG4105CZE	histidine utilization repressor
E4188_RS06065	ENOG41077A9	carbonic anhydrase
E4188_RS06070	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
E4188_RS06075	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
E4188_RS06080	ENOG4105CAK	Cell division ATP-binding protein ftsE
E4188_RS06085	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
E4188_RS06090	ENOG4106H78	methyltransferase
E4188_RS06100	ENOG4108Y73	Membrane
E4188_RS06105	ENOG4105EJ2	Transcriptional regulator
E4188_RS06115	ENOG4107RZC	phospholipase d
E4188_RS06125	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
E4188_RS06145	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
E4188_RS06150	ENOG4105VVZ	metal-binding protein
E4188_RS06165	ENOG4105JQN	Transcriptional regulator
E4188_RS06180	ENOG4107FS9	Membrane
E4188_RS06200	ENOG4105CUG	Oligopeptidase b
E4188_RS06215	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
E4188_RS06240	ENOG410600T	transposase
E4188_RS06250	ENOG4105EQR	Transposase IS116 IS110 IS902
E4188_RS06285	ENOG4108ZT0	50S ribosomal protein l17
E4188_RS06290	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E4188_RS06295	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
E4188_RS06300	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
E4188_RS06305	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4188_RS06310	ENOG41067V7	50S ribosomal protein L36
E4188_RS06315	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
E4188_RS06320	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
E4188_RS06325	ENOG4105VPB	50S ribosomal protein L30
E4188_RS06330	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
E4188_RS06335	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
E4188_RS06340	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
E4188_RS06345	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
E4188_RS06350	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
E4188_RS06355	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4188_RS06360	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
E4188_RS06365	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
E4188_RS06370	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
E4188_RS06375	ENOG41083MP	50s ribosomal protein l29
E4188_RS06380	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
E4188_RS06385	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
E4188_RS06390	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
E4188_RS06395	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
E4188_RS06400	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4188_RS06405	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
E4188_RS06410	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
E4188_RS06415	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
E4188_RS06420	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
E4188_RS06430	ENOG4105E0F	Histidine kinase
E4188_RS06465	ENOG4105EKQ	RNA-directed DNA polymerase
E4188_RS06500	ENOG410600T	transposase
E4188_RS06520	ENOG4107U7B	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E4188_RS06525	ENOG4107RFB	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E4188_RS06530	ENOG4105E0X	reductase
E4188_RS06555	ENOG4105D70	Integrase catalytic subunit
E4188_RS06560	ENOG4105F5W	AtP-binding protein
E4188_RS06570	ENOG4105BZU	Histidine kinase
E4188_RS06575	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E4188_RS06585	ENOG4105E0X	reductase
E4188_RS06595	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E4188_RS06635	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
E4188_RS06640	ENOG4105KT5	UmuD protein
E4188_RS06650	ENOG4105CVR	type I restriction-modification system
E4188_RS06660	ENOG410600T	transposase
E4188_RS06680	ENOG4108RRZ	Transcription elongation factor GreB
E4188_RS06705	ENOG4105BZM	domain protein
E4188_RS06720	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
E4188_RS06725	ENOG4105MJ2	Competence protein
E4188_RS06730	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
E4188_RS06735	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
E4188_RS06740	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
E4188_RS06745	ENOG4107YZP	Rhodanese domain protein
E4188_RS06750	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
E4188_RS06755	ENOG41063SB	peptidase
E4188_RS06765	ENOG4105DIQ	Transcriptional regulator
E4188_RS06770	ENOG4108UHU	Aldolase
E4188_RS06775	ENOG4105C01	Dihydroxy-acid dehydratase
E4188_RS06780	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
E4188_RS06785	ENOG4105C6Z	Gluconate
E4188_RS06790	ENOG4105JIM	Phosphatidylserine synthase
E4188_RS06800	ENOG4105CB5	ATP-dependent DNA helicase recG
E4188_RS06810	ENOG4105SUU	thioesterase domain
E4188_RS06820	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
E4188_RS06825	ENOG4107S2Z	UPF0761 membrane protein
E4188_RS06830	ENOG4105CI3	gtp-binding protein typa
E4188_RS06835	ENOG4105C5F	glutamine synthetase
E4188_RS06845	ENOG4105CUX	Signal transduction histidine kinase
E4188_RS06850	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E4188_RS06855	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
E4188_RS06860	ENOG4105D4P	Coproporphyrinogen iii oxidase
E4188_RS06865	ENOG4105XCT	Protein of unknown function (DUF2489)
E4188_RS06870	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
E4188_RS06875	ENOG4106RE7	Cytochrome
E4188_RS06880	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
E4188_RS06885	ENOG4105E2X	shikimate dehydrogenase
E4188_RS06890	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
E4188_RS06895	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
E4188_RS06900	ENOG4108WI1	Dna topoisomerase
E4188_RS06905	ENOG4108RPN	Protein smg homolog
E4188_RS06910	ENOG4105C79	DNA protecting protein DprA
E4188_RS06920	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
E4188_RS06925	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
E4188_RS06930	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E4188_RS06935	ENOG4105C1A	potassium transporter peripheral membrane
E4188_RS06940	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
E4188_RS06945	ENOG4105CGY	Dna recombination protein
E4188_RS06965	ENOG4108TFM	Kinase, PfkB family
E4188_RS06970	ENOG4107R11	Transcriptional regulator
E4188_RS06975	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E4188_RS06980	ENOG4105C26	Dehydrogenase
E4188_RS06990	ENOG4108JCI	Transcriptional regulator
E4188_RS06995	ENOG4105C26	Dehydrogenase
E4188_RS07005	ENOG4105FR1	rard protein
E4188_RS07010	ENOG4105ECQ	AraC Family Transcriptional Regulator
E4188_RS07015	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
E4188_RS07020	ENOG4105CUC	YeeE YedE family protein
E4188_RS07025	ENOG4108YH8	Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity)
E4188_RS07045	ENOG41061EV	selenium-binding protein YdfZ
E4188_RS07055	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E4188_RS07075	ENOG410600T	transposase
E4188_RS07090	ENOG4105C4R	Atp-dependent dna helicase
E4188_RS07105	ENOG4105DIH	basic membrane
E4188_RS07110	ENOG4108JQ9	ABC transporter
E4188_RS07115	ENOG4105UIB	(ABC) transporter
E4188_RS07135	ENOG4105CC0	LysR family Transcriptional regulator
E4188_RS07160	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
E4188_RS07165	ENOG4105DHU	Bile acid
E4188_RS07170	ENOG4105E5D	amino acid
E4188_RS07175	ENOG4108Y51	tRNA-binding protein
E4188_RS07180	ENOG4105E5D	amino acid
E4188_RS07185	ENOG4105FK9	beta-D-galactosidase beta subunit
E4188_RS07190	ENOG4105CNT	hydrolase family 2
E4188_RS07195	ENOG4105CQ4	Transcriptional regulator
E4188_RS07235	ENOG4108Z0R	Transferase
E4188_RS07240	ENOG4105C2M	dna polymerase I
E4188_RS07245	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
E4188_RS07250	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
E4188_RS07260	ENOG4105D7W	serine acetyltransferase
E4188_RS07270	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
E4188_RS07275	ENOG4105E0F	Histidine kinase
E4188_RS07280	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
E4188_RS07285	ENOG4107R73	Mate efflux family protein
E4188_RS07300	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
E4188_RS07305	ENOG4105E55	glycerol-3-phosphate acyltransferase
E4188_RS07310	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
E4188_RS07315	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
E4188_RS07320	ENOG4105X6C	Flagellar basal body-associated protein FliL
E4188_RS07335	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
E4188_RS07355	ENOG4105PF3	O-Antigen polymerase
E4188_RS07360	ENOG4105E2K	Glycosyl transferase (Group 1
E4188_RS07365	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
E4188_RS07370	ENOG41062JF	Transcriptional regulator
E4188_RS07375	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E4188_RS07380	ENOG4105CPQ	Dehydrogenase
E4188_RS07390	ENOG4105BZU	Histidine kinase
E4188_RS07395	ENOG4105C4R	Atp-dependent dna helicase
E4188_RS07400	ENOG4105C9B	Cysteine desulfurase
E4188_RS07405	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
E4188_RS07410	ENOG4105CUZ	uba thif-type nad fad binding protein
E4188_RS07445	ENOG4108RR8	protoporphyrinogen oxidase
E4188_RS07450	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
E4188_RS07455	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
E4188_RS07460	ENOG4105D9Y	Splits dipeptides with a prolyl residue in the C- terminal position (By similarity)
E4188_RS07465	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
E4188_RS07470	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
E4188_RS07475	ENOG4105CHU	acetyl-coa acetyltransferase
E4188_RS07485	ENOG4105E0F	Histidine kinase
E4188_RS07490	ENOG4105T29	extracellular solute-binding protein
E4188_RS07500	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
E4188_RS07505	ENOG4105M4H	endoribonuclease L-psp
E4188_RS07510	ENOG4108ZG0	Ompa motb domain protein
E4188_RS07535	ENOG4108R3E	Dna-3-methyladenine glycosylase i
E4188_RS07540	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
E4188_RS07545	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
E4188_RS07580	ENOG4105CIC	tryptophan-specific transport protein
E4188_RS07585	ENOG4105CIC	tryptophan-specific transport protein
E4188_RS07600	ENOG4105HEE	Binding Domain protein
E4188_RS07610	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
E4188_RS07615	ENOG4105CNW	domain protein
E4188_RS07620	ENOG4108JUA	Transcriptional regulator
E4188_RS07625	ENOG4105ETE	Transcriptional regulator (LacI family
E4188_RS07630	ENOG4105CP9	extracellular ligand-binding receptor
E4188_RS07635	ENOG4105C32	Amino acid ABC transporter (Permease)
E4188_RS07640	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
E4188_RS07645	ENOG4105C0Z	ABC transporter
E4188_RS07650	ENOG4108IV0	ABC, transporter
E4188_RS07665	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
E4188_RS07680	ENOG4105W0Z	cytoplasmic protein
E4188_RS07685	ENOG4107QK7	reductase
E4188_RS07690	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
E4188_RS07700	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
E4188_RS07710	ENOG4105C1J	atp-dependent rna helicase
E4188_RS07715	ENOG4105C9X	ppx gppa phosphatase
E4188_RS07730	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
E4188_RS07735	ENOG4105BZU	Histidine kinase
E4188_RS07740	ENOG4105DGW	oligopeptidase A
E4188_RS07745	ENOG4105D52	delta-aminolevulinic acid dehydratase
E4188_RS07750	ENOG4105F8V	Hydrolase, tatD family
E4188_RS07755	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
E4188_RS07760	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
E4188_RS07765	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
E4188_RS07770	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
E4188_RS07775	ENOG4105JC1	sterol-binding domain protein
E4188_RS07780	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
E4188_RS07785	ENOG4105WMR	Protein CrcB homolog
E4188_RS07790	ENOG4105DZC	cytosine deaminase
E4188_RS07795	ENOG4105DQW	permease for cytosine purines, uracil, thiamine, allantoin
E4188_RS07830	ENOG410822N	TonB family
E4188_RS07835	ENOG4109015	Biopolymer transport protein exbD tolR
E4188_RS07855	ENOG4105VJY	transcriptional regulator
E4188_RS07865	ENOG4108I5C	dEAD DEAH box helicase
E4188_RS07880	ENOG4105F2I	Transposase
E4188_RS07920	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
E4188_RS07925	ENOG410804X	Transcriptional regulator
E4188_RS07930	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
E4188_RS07935	ENOG4105EB3	Histidine kinase
E4188_RS07950	ENOG4105CT7	inner membrane cred family protein
E4188_RS07955	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
E4188_RS07960	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
E4188_RS07965	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
E4188_RS07970	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
E4188_RS07975	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
E4188_RS07980	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E4188_RS07985	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E4188_RS07990	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
E4188_RS07995	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
E4188_RS08005	ENOG4105FA0	parb-like partition protein
E4188_RS08010	ENOG4107QJE	Chromosome Partitioning Protein
E4188_RS08015	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
E4188_RS08020	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
E4188_RS08025	ENOG4105QTB	Flavodoxin
E4188_RS08030	ENOG4105E0K	tonB-dependent siderophore receptor
E4188_RS08035	ENOG4105IBP	Cyclic peptide transporter
E4188_RS08040	ENOG4105E0A	ABC, transporter
E4188_RS08045	ENOG4105J76	Periplasmic binding protein
E4188_RS08050	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
E4188_RS08060	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
E4188_RS08065	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
E4188_RS08070	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
E4188_RS08075	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
E4188_RS08080	ENOG4105VG0	50S ribosomal protein l34
E4188_RS08085	ENOG4105CDA	abc transporter atp-binding protein
E4188_RS08090	ENOG4105E5Q	amino acid AbC transporter
E4188_RS08095	ENOG4105EAB	amino acid AbC transporter
E4188_RS08100	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
E4188_RS08105	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
E4188_RS08110	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
E4188_RS08115	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4188_RS08125	ENOG4105D29	Helix-turn-helix type 11 domain protein
E4188_RS08135	ENOG4105IGJ	Zn-dependent Hydrolase of the beta-lactamase fold protein
E4188_RS08140	ENOG4108ZNX	Heat shock protein
E4188_RS08145	ENOG4108ZNX	Heat shock protein
E4188_RS08150	ENOG4105JKW	Valine--pyruvate aminotransferase
E4188_RS08165	ENOG4105C2C	drug resistance transporter, Bcr CflA
E4188_RS08170	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
E4188_RS08175	ENOG4105C08	Histidine kinase
E4188_RS08180	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
E4188_RS08185	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
E4188_RS08190	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
E4188_RS08195	ENOG4105KVH	Transcriptional regulator
E4188_RS08200	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
E4188_RS08205	ENOG4105CB2	alcohol dehydrogenase
E4188_RS08210	ENOG4108RKS	Short-chain dehydrogenase reductase Sdr
E4188_RS08215	ENOG4105DC8	reductase
E4188_RS08220	ENOG4105BZU	Histidine kinase
E4188_RS08225	ENOG4105BZS	acriflavin resistance protein
E4188_RS08230	ENOG410624X	efflux transporter, rnd family, mfp subunit
E4188_RS08235	ENOG4105Y7M	Transcriptional regulator, TetR family
E4188_RS08265	ENOG4105DQF	Hydrolase
E4188_RS08270	ENOG4108EUD	Lysophospholipase
E4188_RS08275	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
E4188_RS08280	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
E4188_RS08285	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
E4188_RS08295	ENOG4105DKP	glycosyl transferase, family 9
E4188_RS08300	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
E4188_RS08310	ENOG4105EMK	carboxylate amino acid amine transporter
E4188_RS08340	ENOG4108M6U	Universal stress protein A
E4188_RS08345	ENOG4105RKW	reductase (By
E4188_RS08350	ENOG4105BZU	Histidine kinase
E4188_RS08355	ENOG41090A1	ferritin
E4188_RS08360	ENOG4105CBX	hi0933 family
E4188_RS08365	ENOG4105EU0	Major facilitator Superfamily
E4188_RS08375	ENOG4108HRK	Histidine kinase
E4188_RS08380	ENOG4105DY9	regulatoR
E4188_RS08385	ENOG4105FCD	Major Facilitator
E4188_RS08390	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
E4188_RS08395	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
E4188_RS08400	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
E4188_RS08405	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
E4188_RS08435	ENOG4105CD5	CoA-binding domain protein
E4188_RS08445	ENOG4105EMY	transcriptional regulator
E4188_RS08450	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
E4188_RS08455	ENOG4107QP8	phosphohexose isomerase
E4188_RS08465	ENOG4105D64	Mechanosensitive ion channel
E4188_RS08470	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
E4188_RS08480	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
E4188_RS08485	ENOG4105F2I	Transposase
E4188_RS08515	ENOG4105DFG	type I secretion outer membrane protein
E4188_RS08520	ENOG4105F5W	AtP-binding protein
E4188_RS08525	ENOG4105D70	Integrase catalytic subunit
E4188_RS08545	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E4188_RS08570	ENOG4105EQR	Transposase IS116 IS110 IS902
E4188_RS08595	ENOG4105E3B	Multicopper oxidase
E4188_RS08605	ENOG4105F2I	Transposase
E4188_RS08620	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
E4188_RS08625	ENOG4105W5Q	DNA repair protein (RadC
E4188_RS08630	ENOG4105KDC	50s ribosomal protein l28
E4188_RS08635	ENOG4105W0E	50S ribosomal protein L33
E4188_RS08645	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
E4188_RS08650	ENOG4108MJ5	VirK protein
E4188_RS08655	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
E4188_RS08660	ENOG4105M5K	heptosyltransferase
E4188_RS08665	ENOG4106WTF	Glycosyl transferase, family 2
E4188_RS08670	ENOG4105XA0	heptosyltransferase ii
E4188_RS08675	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
E4188_RS08685	ENOG4105DSJ	YicC domain protein
E4188_RS08690	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
E4188_RS08695	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
E4188_RS08715	ENOG4105PC1	Conserved Protein
E4188_RS08725	ENOG4105E27	serine threonine protein kinase
E4188_RS08730	ENOG4108Z33	Thiol disulfide Interchange Protein
E4188_RS08735	ENOG4105S7S	phosphonate abc transporter
E4188_RS08740	ENOG4108VA1	ABC transporter
E4188_RS08745	ENOG4105EHI	Phosphonate ABC transporter, periplasmic
E4188_RS08750	ENOG4107RH7	Nicotinate phosphoribosyltransferase
E4188_RS08755	ENOG4108RWI	nicotinamidase
E4188_RS08765	ENOG4105EWC	Purine nucleoside phosphorylase
E4188_RS08770	ENOG4106HNH	Acyl-transferase
E4188_RS08775	ENOG4106HNH	Acyl-transferase
E4188_RS08780	ENOG4105C0P	Mg chelatase subunit ChlI
E4188_RS08790	ENOG4105P3Y	Acetolactate synthase 2 regulatory subunit
E4188_RS08795	ENOG4105CM2	brancheD-chain amino acid aminotransferase
E4188_RS08800	ENOG4105C01	Dihydroxy-acid dehydratase
E4188_RS08805	ENOG4105C7B	Threonine dehydratase
E4188_RS08820	ENOG4105UYK	outer membrane protein a
E4188_RS08825	ENOG4105C25	Primosomal protein n'
E4188_RS08830	ENOG4105VFB	Binds the 23S rRNA (By similarity)
E4188_RS08835	ENOG4105CGD	Nad-dependent epimerase dehydratase
E4188_RS08840	ENOG4105C6K	Malic enzyme
E4188_RS08850	ENOG4105JJR	Histidine kinase
E4188_RS08855	ENOG4107EXC	regulatoR
E4188_RS08860	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
E4188_RS08875	ENOG4107R28	alpha amylase, catalytic region
E4188_RS08890	ENOG4105R8A	Heat shock protein
E4188_RS08895	ENOG4105C5I	Dehydrogenase
E4188_RS08900	ENOG4108RH0	Crea protein
E4188_RS08915	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4188_RS08920	ENOG4105CFQ	glutamine synthetase
E4188_RS08925	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
E4188_RS08935	ENOG4108HM4	ABC transporter
E4188_RS08940	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E4188_RS08945	ENOG4105F38	ABC transporter, permease
E4188_RS08950	ENOG4105D38	putrescine abc transporter
E4188_RS08955	ENOG4108RPX	mosc domain containing protein
E4188_RS08975	ENOG4108VUY	thioesterase Superfamily protein
E4188_RS08980	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E4188_RS08985	ENOG4105N7H	Cytochrome
E4188_RS08990	ENOG4105CNG	UPF0061 protein
E4188_RS09000	ENOG4105EX9	Membrane
E4188_RS09005	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
E4188_RS09010	ENOG4105CJW	magnesium transporter
E4188_RS09015	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
E4188_RS09020	ENOG4107V9H	nitrite transporter
E4188_RS09030	ENOG4105WZK	nitrite reductase NADPH small subunit
E4188_RS09035	ENOG4107QZF	nitrite reductase NADPH large subunit
E4188_RS09040	ENOG4107QWP	ABC-2 type transporter
E4188_RS09045	ENOG4107QWP	ABC-2 type transporter
E4188_RS09050	ENOG4105CJ1	ABC, transporter
E4188_RS09055	ENOG4105D0S	secretion protein (HlyD
E4188_RS09075	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
E4188_RS09080	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
E4188_RS09090	ENOG4105C75	arginyL-tRNA synthetase
E4188_RS09100	ENOG4105K6V	RNA polymerase
E4188_RS09105	ENOG4108NIX	Factor ChrR
E4188_RS09110	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
E4188_RS09115	ENOG4105CPC	Aldo Keto reductase
E4188_RS09120	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
E4188_RS09125	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
E4188_RS09130	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
E4188_RS09135	ENOG4105CMR	udp-glucose 4-epimerase
E4188_RS09140	ENOG41060NJ	transcriptional regulator
E4188_RS09145	ENOG4105CNT	hydrolase family 2
E4188_RS09160	ENOG4108HWV	)-transporter
E4188_RS09165	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS09185	ENOG4105C5B	carbamate kinase
E4188_RS09190	ENOG4105DBV	ornithine carbamoyltransferase
E4188_RS09195	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
E4188_RS09200	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
E4188_RS09205	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
E4188_RS09210	ENOG4105CXT	aspartate transcarbamylase
E4188_RS09235	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS09240	ENOG4105QNF	Outer membrane lipoprotein
E4188_RS09245	ENOG4105CF7	AraC family transcriptional regulator
E4188_RS09250	ENOG4108I6A	alcohol dehydrogenase
E4188_RS09255	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
E4188_RS09260	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
E4188_RS09265	ENOG4105CEM	UPF0597 protein
E4188_RS09270	ENOG4107R6U	sodium dicarboxylate symporter
E4188_RS09275	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
E4188_RS09280	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4188_RS09285	ENOG4105C34	Pseudouridine synthase
E4188_RS09290	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
E4188_RS09295	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E4188_RS09300	ENOG4105CU9	asparagine synthetase A
E4188_RS09305	ENOG4108VVK	transcriptional Regulator, AsnC
E4188_RS09320	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E4188_RS09325	ENOG410642E	Short chain dehydrogenase
E4188_RS09340	ENOG4107WP9	Histidine kinase
E4188_RS09350	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E4188_RS09355	ENOG4108UQ5	membrane protein YcdZ
E4188_RS09365	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
E4188_RS09380	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
E4188_RS09385	ENOG4105IFJ	Histidine kinase
E4188_RS09395	ENOG4107QY8	reductase
E4188_RS09400	ENOG4105CUW	cytochrome C-TYPE protein
E4188_RS09405	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
E4188_RS09415	ENOG4107ZYR	domain protein
E4188_RS09420	ENOG4105D4A	Cell wall formation (By similarity)
E4188_RS09425	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
E4188_RS09430	ENOG4105CS9	pantothenic acid kinase
E4188_RS09445	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E4188_RS09455	ENOG4105PM1	preprotein translocase subunit SecE
E4188_RS09460	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
E4188_RS09465	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
E4188_RS09470	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
E4188_RS09475	ENOG4108VZM	50s ribosomal protein L10
E4188_RS09480	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
E4188_RS09485	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E4188_RS09490	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
E4188_RS09495	ENOG4105WWK	YheO domain protein
E4188_RS09500	ENOG4105KME	endoribonuclease L-psp
E4188_RS09515	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
E4188_RS09520	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
E4188_RS09525	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
E4188_RS09530	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
E4188_RS09535	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
E4188_RS09540	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
E4188_RS09575	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
E4188_RS09580	ENOG4105C7N	Xanthine uracil vitamin C permease
E4188_RS09585	ENOG4105CMT	Dihydroxyacetone kinase
E4188_RS09590	ENOG4108UTZ	Dihydroxyacetone kinase
E4188_RS09605	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
E4188_RS09615	ENOG4105IPI	Membrane
E4188_RS09640	ENOG4105CH6	catalase
E4188_RS09645	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
E4188_RS09665	ENOG4105BZU	Histidine kinase
E4188_RS09675	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E4188_RS09710	ENOG4105CWB	LysR family transcriptional Regulator
E4188_RS09720	ENOG4105C2I	pirin domain protein
E4188_RS09725	ENOG4108VBZ	doxx family
E4188_RS09730	ENOG4105DSY	exodeoxyribonuclease V, gamma
E4188_RS09735	ENOG4107QKA	exodeoxyribonuclease V beta
E4188_RS09740	ENOG4107QYX	exodeoxyribonuclease v alpha
E4188_RS09760	ENOG4105KHA	Glyoxalase Bleomycin resistance protein (Dioxygenase
E4188_RS09775	ENOG4108YZA	Nitrogen regulatory protein pii
E4188_RS09780	ENOG4105BZU	Histidine kinase
E4188_RS09790	ENOG4108NVR	Methyl-accepting chemotaxis
E4188_RS09805	ENOG4105E0F	Histidine kinase
E4188_RS09810	ENOG4105VEQ	Cold shock protein
E4188_RS09835	ENOG4108IMY	Transcriptional regulator
E4188_RS09865	ENOG4105C7H	Helicase, RecD TraA family
E4188_RS09900	ENOG4108UUM	single-stranded DNA-binding protein
E4188_RS09905	ENOG41086KC	Transcriptional regulator
E4188_RS09910	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
E4188_RS09915	ENOG4105EIF	outer membrane protein W
E4188_RS09935	ENOG4105SYT	Methylenetetrahydrofolate reductase
E4188_RS09965	ENOG4105EMU	Dehydrogenase
E4188_RS09980	ENOG4108I6A	alcohol dehydrogenase
E4188_RS09990	ENOG4108IQK	o-acetylhomoserine
E4188_RS10020	ENOG4107IFA	Lipase (EC 3.1.1.3)
E4188_RS10035	ENOG4108UB4	uncharacterized protein ygjQ
E4188_RS10040	ENOG4107MM9	BNR Asp-box repeat-containing protein
E4188_RS10045	ENOG4105CEY	Amp-dependent synthetase and ligase
E4188_RS10050	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
E4188_RS10055	ENOG4108IPT	Naphthoate synthase
E4188_RS10060	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
E4188_RS10065	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
E4188_RS10070	ENOG4105E4F	Isochorismate synthase
E4188_RS10075	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
E4188_RS10100	ENOG4105C1J	atp-dependent rna helicase
E4188_RS10105	ENOG4105D9N	nucleoside
E4188_RS10135	ENOG4105CVR	type I restriction-modification system
E4188_RS10140	ENOG4108UPT	UPF0178 protein
E4188_RS10165	ENOG4105E61	Mannitol repressor protein
E4188_RS10170	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
E4188_RS10175	ENOG4105CTS	PTS system mannitol-specific
E4188_RS10180	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
E4188_RS10185	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
E4188_RS10190	ENOG4105NNS	Autoinducer synthesis protein
E4188_RS10195	ENOG4105VJY	transcriptional regulator
E4188_RS10200	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
E4188_RS10205	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
E4188_RS10210	ENOG4105D1S	lipid A biosynthesis
E4188_RS10215	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
E4188_RS10220	ENOG4105DFG	type I secretion outer membrane protein
E4188_RS10225	ENOG41087AY	ADP-Ribose pyrophosphatase
E4188_RS10230	ENOG4108SX3	cytoplasmic protein
E4188_RS10235	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
E4188_RS10240	ENOG4105IPS	esterase
E4188_RS10255	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4188_RS10260	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4188_RS10325	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
E4188_RS10335	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4188_RS10355	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
E4188_RS10360	ENOG41087YS	Phage shock protein A
E4188_RS10375	ENOG41082IR	Excinuclease ABC C subunit domain protein
E4188_RS10380	ENOG4105FR1	rard protein
E4188_RS10385	ENOG4108RG0	uracil-dna glycosylase
E4188_RS10395	ENOG4105ETT	transcriptional Regulator, LysR family
E4188_RS10400	ENOG4105FAV	ABC, transporter
E4188_RS10405	ENOG4105FDK	ABC transporter
E4188_RS10410	ENOG4105NXV	High-affinity zinc uptake system protein
E4188_RS10430	ENOG4105DR5	peptidase
E4188_RS10440	ENOG4105R2J	Conserved Protein
E4188_RS10460	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
E4188_RS10470	ENOG4107TH8	cina domain protein
E4188_RS10475	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
E4188_RS10485	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
E4188_RS10490	ENOG4105CFH	Aspartokinase
E4188_RS10495	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
E4188_RS10530	ENOG41061WM	D-Alanyl-D-Alanine
E4188_RS10535	ENOG4106W5V	Membrane
E4188_RS10555	ENOG4105MYG	DNA polymerase iii, chi subunit
E4188_RS10560	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E4188_RS10565	ENOG4108M8S	permease YjgP YjgQ family protein
E4188_RS10570	ENOG4108K5H	permease YjgP YjgQ family protein
E4188_RS10590	ENOG4105BZU	Histidine kinase
E4188_RS10595	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
E4188_RS10615	ENOG4105EYA	deoxyribonuclease
E4188_RS10620	ENOG4105D9N	nucleoside
E4188_RS10630	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
E4188_RS10635	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
E4188_RS10640	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
E4188_RS10655	ENOG4108NST	exported protein
E4188_RS10665	ENOG4105EAC	phosphoserine phosphatase
E4188_RS10680	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
E4188_RS10690	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
E4188_RS10695	ENOG4105K70	DNA-binding protein
E4188_RS10710	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
E4188_RS10715	ENOG4105MYN	Zinc uptake regulation protein
E4188_RS10730	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
E4188_RS10735	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
E4188_RS10740	ENOG4105C1J	atp-dependent rna helicase
E4188_RS10745	ENOG4105D1Q	UPF0246 protein
E4188_RS10755	ENOG4105CZX	twitching motility protein
E4188_RS10760	ENOG4105DFA	alanine racemase domain protein
E4188_RS10765	ENOG4105II7	pyrroline-5-carboxylate reductase
E4188_RS10770	ENOG4108VIA	integral membrane protein
E4188_RS10775	ENOG4105VZ9	UPF0235 protein
E4188_RS10795	ENOG4105XTV	UPF0231 protein
E4188_RS10800	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
E4188_RS10805	ENOG4107QQ0	gntp family
E4188_RS10810	ENOG4105BZW	Glycerate kinase
E4188_RS10825	ENOG4105HEI	LysR family (Transcriptional regulator
E4188_RS10830	ENOG4105D9N	nucleoside
E4188_RS10840	ENOG4108YZN	class I peptide chain release factor
E4188_RS10845	ENOG4108YZA	Nitrogen regulatory protein pii
E4188_RS10850	ENOG4107QKW	extracellular solute-binding protein family 1
E4188_RS10860	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
E4188_RS10865	ENOG4105EZR	dyp-type peroxidase family protein
E4188_RS10870	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
E4188_RS10875	ENOG4105E5Z	arginine transporter ATP-binding subunit
E4188_RS10880	ENOG4106PMH	Extracellular solute-binding protein family 3
E4188_RS10885	ENOG4105GBT	ABC transporter
E4188_RS10890	ENOG4105DMR	ABC, transporter
E4188_RS10895	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
E4188_RS10910	ENOG4108EGH	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
E4188_RS10920	ENOG4108JU6	CBS domain protein
E4188_RS10925	ENOG4106KVJ	cytochrome C assembly protein
E4188_RS10930	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4188_RS10935	ENOG4105K5M	30s ribosomal protein S16
E4188_RS10940	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
E4188_RS10945	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
E4188_RS10950	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
E4188_RS10965	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
E4188_RS10970	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
E4188_RS10975	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
E4188_RS10985	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4188_RS11010	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
E4188_RS11015	ENOG4105F2I	Transposase
E4188_RS11025	ENOG4105DIJ	Phosphoethanolamine transferase
E4188_RS11030	ENOG4105DIJ	Phosphoethanolamine transferase
E4188_RS11035	ENOG41080IJ	Diacylglycerol kinase
E4188_RS11055	ENOG4108YX2	DNA-binding protein
E4188_RS11065	ENOG410600T	transposase
E4188_RS11085	ENOG4105D70	Integrase catalytic subunit
E4188_RS11090	ENOG4105F5W	AtP-binding protein
E4188_RS11100	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
E4188_RS11110	ENOG41063Z6	transcriptional regulator, lysR family
E4188_RS11115	ENOG41080HT	Transcriptional regulator, arsr family
E4188_RS11120	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
E4188_RS11125	ENOG4105CJR	Integral membrane protein (MviN
E4188_RS11130	ENOG4105DTN	riboflavin biosynthesis protein ribF
E4188_RS11135	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
E4188_RS11140	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
E4188_RS11145	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
E4188_RS11150	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
E4188_RS11180	ENOG4105C4K	Nad synthetase
E4188_RS11185	ENOG4108YZA	Nitrogen regulatory protein pii
E4188_RS11195	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
E4188_RS11200	ENOG4106TD9	Diguanylate cyclase
E4188_RS11205	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
E4188_RS11220	ENOG4107YB6	acetyltransferase, (GNAT) family
E4188_RS11235	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
E4188_RS11240	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
E4188_RS11245	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
E4188_RS11250	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
E4188_RS11255	ENOG4105DP0	ferredoxin-NADP reductase
E4188_RS11280	ENOG4105DQ4	alcohol dehydrogenase
E4188_RS11285	ENOG4105W39	Membrane
E4188_RS11295	ENOG4105D9M	gamma-glutamylcysteine synthetase
E4188_RS11300	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
E4188_RS11305	ENOG4108IJ0	Aspartate ammonia-lyase
E4188_RS11310	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
E4188_RS11320	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
E4188_RS11325	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
E4188_RS11335	ENOG4105BZU	Histidine kinase
E4188_RS11345	ENOG4105D3G	Pseudouridine synthase
E4188_RS11350	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
E4188_RS11380	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
E4188_RS11390	ENOG4108I5D	sulfate abc transporter
E4188_RS11395	ENOG4105ECW	sulfate abc transporter
E4188_RS11400	ENOG4108IJ6	ABC transporter
E4188_RS11405	ENOG4107R11	Transcriptional regulator
E4188_RS11415	ENOG4108M1A	Chitin-binding protein
E4188_RS11420	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS11445	ENOG4105G0K	glycine radical enzyme YjjI family
E4188_RS11450	ENOG41076CZ	activating enzyme
E4188_RS11465	ENOG4105CGF	Aromatic amino acid aminotransferase
E4188_RS11485	ENOG4107QZ7	Cellulose synthase catalytic subunit
E4188_RS11490	ENOG4107EEX	Cellulose synthase regulator protein
E4188_RS11495	ENOG4105K2Z	endo-1,4-d-glucanase (EC 3.2.1.4)
E4188_RS11500	ENOG4105EJG	cellulose synthase
E4188_RS11530	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
E4188_RS11535	ENOG4105C1J	atp-dependent rna helicase
E4188_RS11550	ENOG4108QYW	Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity)
E4188_RS11555	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
E4188_RS11565	ENOG4107QSI	ABC, transporter
E4188_RS11575	ENOG4106WH9	Protein of unknown function (DUF2753)
E4188_RS11580	ENOG4105E39	Enoyl-CoA hydratase
E4188_RS11595	ENOG4108RZ4	Short-chain dehydrogenase reductase Sdr
E4188_RS11600	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
E4188_RS11605	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
E4188_RS11610	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
E4188_RS11620	ENOG4105C4M	(Ubiquinol oxidase) subunit I
E4188_RS11625	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
E4188_RS11635	ENOG4105KJB	cyd operon protein YbgE
E4188_RS11640	ENOG4107YD3	Thioesterase
E4188_RS11645	ENOG4105E02	MotA TolQ exbB proton channel
E4188_RS11650	ENOG4105M8F	Biopolymer transport protein exbD tolR
E4188_RS11660	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
E4188_RS11665	ENOG4105KCK	Peptidoglycan-associated lipoprotein
E4188_RS11670	ENOG4105UFD	tol-pal system protein YbgF
E4188_RS11745	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
E4188_RS11750	ENOG4105DSB	aldose 1-epimerase
E4188_RS11755	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
E4188_RS11760	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
E4188_RS11765	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
E4188_RS11775	ENOG4105E0X	reductase
E4188_RS11790	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
E4188_RS11795	ENOG4105K56	Transcriptional regulator
E4188_RS11810	ENOG4105EW9	transcriptional regulator AsnC family
E4188_RS11825	ENOG410667J	hydrolase
E4188_RS11840	ENOG4105C8J	)-transporter
E4188_RS11845	ENOG4105C8J	)-transporter
E4188_RS11860	ENOG4107SQD	Transcriptional regulator, GntR family
E4188_RS11885	ENOG4108IQE	Amp-dependent synthetase and ligase
E4188_RS11895	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
E4188_RS11910	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
E4188_RS11915	ENOG4105BZU	Histidine kinase
E4188_RS11925	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
E4188_RS11930	ENOG4108MJ3	acetyltransferase
E4188_RS11935	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E4188_RS11955	ENOG4105DWY	Agmatine deiminase
E4188_RS11960	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
E4188_RS11970	ENOG4105F2I	Transposase
E4188_RS11990	ENOG4105C1J	atp-dependent rna helicase
E4188_RS11995	ENOG4105FSR	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
E4188_RS12005	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
E4188_RS12030	ENOG4107QWG	2-Nitropropane dioxygenase
E4188_RS12065	ENOG4105F5W	AtP-binding protein
E4188_RS12070	ENOG4105D70	Integrase catalytic subunit
E4188_RS12085	ENOG4108IAB	Phoh family
E4188_RS12095	ENOG4106SMU	thiamine transporter membrane protein
E4188_RS12100	ENOG4105DP9	ABC transporter
E4188_RS12115	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E4188_RS12120	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
E4188_RS12125	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
E4188_RS12130	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
E4188_RS12140	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
E4188_RS12145	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
E4188_RS12155	ENOG4105C7K	acetolactate synthase
E4188_RS12160	ENOG4108ZP8	Acetolactate synthase small subunit
E4188_RS12165	ENOG4105C6K	Malic enzyme
E4188_RS12170	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
E4188_RS12180	ENOG4105XWI	UPF0304 protein
E4188_RS12185	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4188_RS12190	ENOG4105RH4	Glycine cleavage system transcriptional repressor
E4188_RS12195	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
E4188_RS12200	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E4188_RS12205	ENOG4107QWK	SAICAR synthetase
E4188_RS12215	ENOG4105EXG	Transcriptional regulator
E4188_RS12240	ENOG4105BZU	Histidine kinase
E4188_RS12245	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
E4188_RS12275	ENOG4105BZU	Histidine kinase
E4188_RS12280	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS12285	ENOG4105MDZ	Transcriptional activator rfaH
E4188_RS12290	ENOG4105D01	(LipO)protein
E4188_RS12295	ENOG4108UMI	ABC transporter, permease
E4188_RS12300	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
E4188_RS12320	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
E4188_RS12325	ENOG4105K8N	protein family UPF0079, ATPase
E4188_RS12330	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
E4188_RS12335	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
E4188_RS12340	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
E4188_RS12345	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
E4188_RS12350	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
E4188_RS12355	ENOG4107QJR	hflk protein
E4188_RS12360	ENOG4105EPW	hflc protein
E4188_RS12370	ENOG4105EAH	synthase
E4188_RS12375	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
E4188_RS12380	ENOG4105K46	50S ribosomal protein l27
E4188_RS12385	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4188_RS12390	ENOG4105DWD	nucleoside recognition domain protein
E4188_RS12395	ENOG4108ESY	Metal dependent phosphohydrolase
E4188_RS12400	ENOG4105DEN	Luciferase family
E4188_RS12410	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
E4188_RS12420	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
E4188_RS12425	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
E4188_RS12435	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
E4188_RS12440	ENOG4105EHM	Aminoglycoside phosphotransferase
E4188_RS12445	ENOG4108S0S	Nucleotidyl transferase
E4188_RS12450	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
E4188_RS12460	ENOG4105C7N	Xanthine uracil vitamin C permease
E4188_RS12470	ENOG4105C5H	ABC transporter
E4188_RS12475	ENOG4105E4C	Lytic transglycosylase catalytic
E4188_RS12480	ENOG4105CKK	Glycosyl transferase, family 2
E4188_RS12490	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
E4188_RS12500	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
E4188_RS12515	ENOG4105EHG	Permease protein
E4188_RS12525	ENOG41090JE	Utilization Protein
E4188_RS12530	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
E4188_RS12555	ENOG4105D8G	Major Facilitator superfamily
E4188_RS12560	ENOG4105BZU	Histidine kinase
E4188_RS12575	ENOG4108MA4	Peptidase M66
E4188_RS12585	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
E4188_RS12590	ENOG4108UKZ	OsmC family
E4188_RS12605	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
E4188_RS12610	ENOG4105YP7	UPF0270 protein
E4188_RS12620	ENOG4105DNZ	Alpha Beta Hydrolase
E4188_RS12635	ENOG4105VKU	nucleicacid-binding protein
E4188_RS12640	ENOG4108YZY	peptidylprolyl cis-trans isomerase
E4188_RS12655	ENOG4108V1T	peptidylprolyl cis-trans isomerase
E4188_RS12660	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
E4188_RS12680	ENOG4105CGH	5'-nucleotidase
E4188_RS12690	ENOG4105CDU	Replicative dna helicase
E4188_RS12695	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
E4188_RS12700	ENOG4105C26	Dehydrogenase
E4188_RS12715	ENOG4105EQ6	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity)
E4188_RS12720	ENOG4108ZXC	Two component transcriptional regulator, luxr family
E4188_RS12725	ENOG4105BZU	Histidine kinase
E4188_RS12730	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
E4188_RS12735	ENOG4106WHD	Tetrathionate reductase
E4188_RS12740	ENOG4105DB1	molybdopterin oxidoreductase
E4188_RS12750	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
E4188_RS12775	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E4188_RS12785	ENOG4105N14	lysine exporter protein LysE YggA
E4188_RS12795	ENOG4105CFP	Peptidase U32
E4188_RS12805	ENOG4105XDF	Protein of unknown function (DUF1272)
E4188_RS12825	ENOG4105CTD	carboxy-peptidase
E4188_RS12850	ENOG4105E1F	short-chain dehydrogenase reductase
E4188_RS12860	ENOG4108W2P	Methyl-accepting chemotaxis
E4188_RS12870	ENOG4105C6Z	Gluconate
E4188_RS12875	ENOG4105EXW	epimerase dehydratase
E4188_RS12880	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
E4188_RS12885	ENOG4105FB2	class II Aldolase
E4188_RS12890	ENOG4105G63	Type III effector Hrp-dependent
E4188_RS12900	ENOG4105MVE	transcriptional regulator
E4188_RS12910	ENOG4105D8V	Glucose sorbosone dehydrogenase
E4188_RS12925	ENOG4105ETE	Transcriptional regulator (LacI family
E4188_RS12945	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
E4188_RS12960	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
E4188_RS12975	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
E4188_RS12980	ENOG410600T	transposase
E4188_RS12985	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
E4188_RS13010	ENOG4105CQC	Prephenate dehydratase
E4188_RS13035	ENOG4107SEY	Conserved Protein
E4188_RS13040	ENOG4108XDN	Transcriptional regulator
E4188_RS13045	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
E4188_RS13055	ENOG4107FW0	short-chain dehydrogenase reductase
E4188_RS13070	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
E4188_RS13095	ENOG4108RMU	ferritin dps family protein
E4188_RS13100	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
E4188_RS13105	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
E4188_RS13110	ENOG4105CMR	udp-glucose 4-epimerase
E4188_RS13145	ENOG4105D6J	arsenicaL-resistance protein
E4188_RS13150	ENOG4105K89	arsenate reductase
E4188_RS13175	ENOG4105CHH	sulfate transporter
E4188_RS13180	ENOG4105VJY	transcriptional regulator
E4188_RS13185	ENOG4108WC9	type VI secretion system effector, hcp1 family
E4188_RS13190	ENOG4105CS6	Rhs element vgr protein
E4188_RS13205	ENOG4105F2I	Transposase
E4188_RS13220	ENOG4107S0N	DJ-1 family
E4188_RS13225	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
E4188_RS13230	ENOG4108VPT	UPF0234 protein
E4188_RS13235	ENOG4105DRB	nucleoside-specific channel-forming protein
E4188_RS13240	ENOG4105EYM	Major Facilitator superfamily
E4188_RS13250	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
E4188_RS13260	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
E4188_RS13265	ENOG4105M85	Bola protein
E4188_RS13270	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4188_RS13275	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4188_RS13280	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4188_RS13285	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4188_RS13290	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
E4188_RS13295	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
E4188_RS13300	ENOG4105CJ2	(LipO)protein
E4188_RS13315	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
E4188_RS13320	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS13325	ENOG4105ETT	transcriptional Regulator, LysR family
E4188_RS13335	ENOG4105M08	Membrane
E4188_RS13340	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
E4188_RS13350	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
E4188_RS13355	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
E4188_RS13360	ENOG4105EWT	decarboxylase family
E4188_RS13365	ENOG4105BZU	Histidine kinase
E4188_RS13375	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
E4188_RS13380	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
E4188_RS13385	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
E4188_RS13410	ENOG4105WP7	tRNA pseudouridine synthase C
E4188_RS13415	ENOG4105DR9	pseudouridine synthase
E4188_RS13420	ENOG4105QDK	Flavodoxin
E4188_RS13425	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
E4188_RS13430	ENOG4107W52	maltose operon periplasmic protein
E4188_RS13435	ENOG4105CI1	PTS System
E4188_RS13440	ENOG4108T8E	UPF0325 protein
E4188_RS13445	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
E4188_RS13450	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
E4188_RS13455	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
E4188_RS13460	ENOG4105CE9	30S ribosomal protein S2
E4188_RS13465	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
E4188_RS13470	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
E4188_RS13475	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
E4188_RS13485	ENOG4105KNE	Phosphatidate cytidylyltransferase
E4188_RS13490	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
E4188_RS13495	ENOG4105DZP	Membrane-associated zinc metalloprotease
E4188_RS13505	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
E4188_RS13510	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E4188_RS13515	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
E4188_RS13520	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E4188_RS13525	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
E4188_RS13530	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E4188_RS13535	ENOG4105C0B	DNA polymerase III (alpha subunit)
E4188_RS13540	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
E4188_RS13550	ENOG410642W	LysR family Transcriptional regulator
E4188_RS13555	ENOG4105C44	Serine transporter
E4188_RS13560	ENOG4105DVH	amino acid
E4188_RS13565	ENOG4105KNA	-acetyltransferase
E4188_RS13570	ENOG4105C5H	ABC transporter
E4188_RS13580	ENOG4105C9K	Endothelin-converting enzyme 1
E4188_RS13590	ENOG4105BZU	Histidine kinase
E4188_RS13625	ENOG4107T9C	Alpha amylase catalytic region
E4188_RS13655	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
E4188_RS13660	ENOG4105EAQ	(twin-arginine translocation) pathway signal
E4188_RS13670	ENOG4105EN6	Membrane
E4188_RS13675	ENOG4105EXN	Sulfate transport protein CysZ
E4188_RS13680	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
E4188_RS13685	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
E4188_RS13690	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
E4188_RS13700	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
E4188_RS13705	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
E4188_RS13730	ENOG4105J12	Multidrug resistance protein mdtN
E4188_RS13740	ENOG4105D2K	citrate carrier protein
E4188_RS13745	ENOG4107R1I	NAD-dependent malic enzyme
E4188_RS13750	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
E4188_RS13755	ENOG4106YYS	transcriptional regulatory protein
E4188_RS13760	ENOG410631K	Membrane
E4188_RS13770	ENOG4105C26	Dehydrogenase
E4188_RS13775	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
E4188_RS13780	ENOG4105BZU	Histidine kinase
E4188_RS13785	ENOG4105F2I	Transposase
E4188_RS13790	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
E4188_RS13795	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
E4188_RS13800	ENOG4105BZU	Histidine kinase
E4188_RS13805	ENOG4105DJH	phosphate
E4188_RS13810	ENOG4105ERG	peptidase m48, ste24p
E4188_RS13820	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
E4188_RS13825	ENOG4106N3A	copper homeostasis protein cutc
E4188_RS13830	ENOG4108V1T	peptidylprolyl cis-trans isomerase
E4188_RS13835	ENOG4105CJ1	ABC, transporter
E4188_RS13855	ENOG4105EZ7	amino acid ABC transporter
E4188_RS13860	ENOG4105DRP	amino acid AbC transporter
E4188_RS13865	ENOG4105CDA	abc transporter atp-binding protein
E4188_RS13875	ENOG4105PTV	Nudix Hydrolase
E4188_RS13895	ENOG4105BZG	amino acid carrier protein
E4188_RS13900	ENOG4108KMH	lipoate-protein ligase a
E4188_RS13905	ENOG4105C2W	permease
E4188_RS13915	ENOG4105RKX	Protein of unknown function (DUF2498)
E4188_RS13920	ENOG4105UQX	Mate efflux family protein
E4188_RS13925	ENOG4105ECQ	AraC Family Transcriptional Regulator
E4188_RS13930	ENOG4107R1I	NAD-dependent malic enzyme
E4188_RS13935	ENOG4105UYK	outer membrane protein a
E4188_RS13945	ENOG4105UYK	outer membrane protein a
E4188_RS13960	ENOG4105C8J	)-transporter
E4188_RS13965	ENOG4105D78	K07001 NTE family protein
E4188_RS13970	ENOG4105BZU	Histidine kinase
E4188_RS13985	ENOG4105CCT	upf0313 protein
E4188_RS13995	ENOG410600T	transposase
E4188_RS14025	ENOG4105CVR	type I restriction-modification system
E4188_RS14040	ENOG4105EP9	oxidoreductase
E4188_RS14045	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
E4188_RS14050	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
E4188_RS14055	ENOG4105E4C	Lytic transglycosylase catalytic
E4188_RS14080	ENOG4105CIY	formyltetrahydrofolate deformylase
E4188_RS14085	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
E4188_RS14095	ENOG4107QR8	Thioredoxin
E4188_RS14100	ENOG4107YAK	holo-(acyl carrier protein) synthase 2
E4188_RS14105	ENOG4107TT5	NLP P60 protein
E4188_RS14110	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
E4188_RS14125	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
E4188_RS14160	ENOG4105CIG	ABC transporter
E4188_RS14165	ENOG4108T0W	nitrous oxide maturation protein NosY
E4188_RS14175	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
E4188_RS14200	ENOG4107RTG	Major Facilitator superfamily
E4188_RS14210	ENOG4105ENX	hydrolase
E4188_RS14215	ENOG4105EQ2	LysR family Transcriptional regulator
E4188_RS14245	ENOG4105XIQ	Protein of unknown function (DUF2517)
E4188_RS14250	ENOG4105BZU	Histidine kinase
E4188_RS14255	ENOG4105D70	Integrase catalytic subunit
E4188_RS14260	ENOG4105F5W	AtP-binding protein
E4188_RS14270	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
E4188_RS14275	ENOG4108V1T	peptidylprolyl cis-trans isomerase
E4188_RS14290	ENOG4105CUB	amino acid
E4188_RS14295	ENOG4105CUB	amino acid
E4188_RS14305	ENOG4108JPW	Aminotransferase
E4188_RS14310	ENOG4105C26	Dehydrogenase
E4188_RS14315	ENOG4107VRI	Transcriptional regulator
E4188_RS14320	ENOG4105CJP	fad dependent oxidoreductase
E4188_RS14340	ENOG4105DH7	May be involved in recombination (By similarity)
E4188_RS14345	ENOG4105K5X	acetyltransferase
E4188_RS14350	ENOG4107RH8	nuclease SbcCD subunit D
E4188_RS14355	ENOG4105EYH	Exonuclease
E4188_RS14360	ENOG4108VKM	cytochrome b561
E4188_RS14365	ENOG4105C5Y	PTS System
E4188_RS14370	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
E4188_RS14375	ENOG4105KZ7	phosphocarrier protein hpr
E4188_RS14380	ENOG4105C6T	cysteine synthase
E4188_RS14400	ENOG4108R96	Methyltransferase, YaeB family
E4188_RS14420	ENOG4108JJ8	(ABC) transporter
E4188_RS14425	ENOG4108JJ9	ABC, transporter
E4188_RS14440	ENOG41065U4	response regulator
E4188_RS14450	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
E4188_RS14485	ENOG4108YYD	acetyltransferase
E4188_RS14505	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
E4188_RS14510	ENOG4108Z1B	Cyclase dehydrase
E4188_RS14515	ENOG4105VDB	UPF0125 protein
E4188_RS14535	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E4188_RS14545	ENOG4107SXA	Phosphorylase
E4188_RS14550	ENOG4105D3G	Pseudouridine synthase
E4188_RS14555	ENOG4105DU0	nucleoside hydrolase
E4188_RS14570	ENOG4105RX8	Protein of unknown function (DUF1523)
E4188_RS14580	ENOG410829K	Lysine exporter protein (Lyse ygga)
E4188_RS14595	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
E4188_RS14610	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
E4188_RS14615	ENOG4105KUZ	arsenate reductase
E4188_RS14630	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
E4188_RS14640	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E4188_RS14655	ENOG4105C5S	asparaginyl-tRNA synthetase
E4188_RS14670	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
E4188_RS14675	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
E4188_RS14680	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
E4188_RS14685	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
E4188_RS14690	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
E4188_RS14695	ENOG4105D0M	Protease HtpX homolog
E4188_RS14700	ENOG4105QVC	MOSC domain-containing protein
E4188_RS14700	ENOG4105QVC	MOSC domain-containing protein
E4188_RS14710	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
E4188_RS14720	ENOG4105Z2P	Protein of unknown function (DUF465)
E4188_RS14730	ENOG4105UQX	Mate efflux family protein
E4188_RS14750	ENOG4105C6T	cysteine synthase
E4188_RS14765	ENOG4108RZE	Tetr family transcriptional regulator
E4188_RS14770	ENOG4107RGH	Aldehyde dehydrogenase
E4188_RS14780	ENOG4107TT5	NLP P60 protein
E4188_RS14785	ENOG4105C5Q	Transcriptional regulator
E4188_RS14805	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
E4188_RS14810	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
E4188_RS14815	ENOG41081XQ	Conserved Protein
E4188_RS14820	ENOG4105C9M	aspartyl-trna synthetase
E4188_RS14825	ENOG4105CDY	transcriptional regulatory protein
E4188_RS14830	ENOG4105DIJ	Phosphoethanolamine transferase
E4188_RS14835	ENOG4105E2R	ROK family
E4188_RS14840	ENOG4105CE4	GlcNAc 6-P deacetylase
E4188_RS14845	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
E4188_RS14850	ENOG4105CI1	PTS System
E4188_RS14855	ENOG4105E2D	ec 3.2.1.52
E4188_RS14860	ENOG4105CX6	glutaminyL-tRNA synthetase
E4188_RS14865	ENOG41090R7	Ferric uptake
E4188_RS14875	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
E4188_RS14880	ENOG4105NNH	LexA regulated protein
E4188_RS14890	ENOG4105EV9	Alpha Beta Hydrolase
E4188_RS14895	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
E4188_RS14900	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
E4188_RS14910	ENOG41090MY	MarR family Transcriptional regulator
E4188_RS14915	ENOG4105CVE	Lytic murein transglycosylase
E4188_RS14920	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
E4188_RS14925	ENOG4108VGW	abc transporter atp-binding protein
E4188_RS14935	ENOG4105VNH	ABC transporter solute-binding protein
E4188_RS14945	ENOG4107ZN8	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
E4188_RS14955	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
E4188_RS14965	ENOG4105CFU	surface antigen
E4188_RS14990	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
E4188_RS14995	ENOG4105BZU	Histidine kinase
E4188_RS15000	ENOG4107SC1	transglycosylase
E4188_RS15005	ENOG41060NJ	transcriptional regulator
E4188_RS15015	ENOG4105NAU	thioesterase Superfamily protein
E4188_RS15030	ENOG4105E9H	Lytic Murein transglycosylase
E4188_RS15035	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
E4188_RS15040	ENOG4105D1A	Methyltransferase
E4188_RS15045	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
E4188_RS15050	ENOG4107RZZ	dna polymerase iii epsilon subunit
E4188_RS15060	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
E4188_RS15065	ENOG4107QPN	acyl-Coa dehydrogenase
E4188_RS15070	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
E4188_RS15075	ENOG4105E7A	Glutamine amidotransferase
E4188_RS15085	ENOG4105CHW	UPF0052 protein
E4188_RS15095	ENOG4105BZU	Histidine kinase
E4188_RS15110	ENOG4105WH1	Two component transcriptional regulator luxr family
E4188_RS15115	ENOG4105BZU	Histidine kinase
E4188_RS15120	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E4188_RS15135	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
E4188_RS15140	ENOG4108BGM	Quinol dehydrogenase periplasmic component
E4188_RS15145	ENOG4105GXZ	Ferredoxin-type protein NapH
E4188_RS15155	ENOG4105CUW	cytochrome C-TYPE protein
E4188_RS15160	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
E4188_RS15165	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
E4188_RS15170	ENOG4105M00	molybdopterin converting factor, subunit 1
E4188_RS15175	ENOG4108ZAF	Molybdopterin
E4188_RS15180	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
E4188_RS15185	ENOG4105E0C	molybdate abc transporter
E4188_RS15190	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
E4188_RS15195	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
E4188_RS15200	ENOG4105D06	uba thif-type nad fad binding protein
E4188_RS15205	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
E4188_RS15210	ENOG4105EUJ	GTP cyclohydrolase i
E4188_RS15215	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS15220	ENOG4105CKU	formyltetrahydrofolate synthetase
E4188_RS15230	ENOG4105CC0	LysR family Transcriptional regulator
E4188_RS15235	ENOG4108YYC	ycei family
E4188_RS15260	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
E4188_RS15270	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
E4188_RS15285	ENOG4105BZU	Histidine kinase
E4188_RS15325	ENOG410600T	transposase
E4188_RS15330	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
E4188_RS15340	ENOG4105D82	Glutamate dehydrogenase
E4188_RS15345	ENOG4105FE9	pseudouridine synthase
E4188_RS15350	ENOG4105DJ2	Major Facilitator Superfamily
E4188_RS15360	ENOG4105JQN	Transcriptional regulator
E4188_RS15370	ENOG4106428	Protein of unknown function (DUF2496)
E4188_RS15390	ENOG4108Q2J	Inner membrane protein YebE
E4188_RS15405	ENOG4105DU6	RNA polymerase
E4188_RS15420	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
E4188_RS15425	ENOG4105C4M	(Ubiquinol oxidase) subunit I
E4188_RS15430	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
E4188_RS15440	ENOG4105F27	Major Facilitator
E4188_RS15445	ENOG4105CV8	reductase
E4188_RS15465	ENOG4105HEI	LysR family (Transcriptional regulator
E4188_RS15470	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
E4188_RS15475	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
E4188_RS15480	ENOG4105CXY	transporter
E4188_RS15485	ENOG4105E98	transcriptional regulator DeoR family
E4188_RS15490	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
E4188_RS15495	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
E4188_RS15500	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
E4188_RS15515	ENOG4108WFC	UPF0438 protein yifE
E4188_RS15520	ENOG4108QSZ	General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity)
E4188_RS15540	ENOG4105CUG	Oligopeptidase b
E4188_RS15545	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
E4188_RS15550	ENOG4105E68	Sulfatase
E4188_RS15555	ENOG4105PAN	UPF0352 protein
E4188_RS15560	ENOG4106V8H	Nucleoid-associated protein
E4188_RS15565	ENOG4107FKK	extracellular solute-binding protein family 1
E4188_RS15570	ENOG4105D56	permease protein
E4188_RS15580	ENOG4108IJ9	(ABC) transporter
E4188_RS15585	ENOG4105CSR	polyphosphate kinase 2
E4188_RS15610	ENOG4105ERG	peptidase m48, ste24p
E4188_RS15620	ENOG4105K89	arsenate reductase
E4188_RS15630	ENOG4105CI2	imidazolone-5-propionate hydrolase
E4188_RS15635	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
E4188_RS15645	ENOG4105DYB	Isoaspartyl dipeptidase
E4188_RS15650	ENOG4105DWU	Membrane
E4188_RS15655	ENOG4108JEH	abc transporter atp-binding protein
E4188_RS15660	ENOG4106PMH	Extracellular solute-binding protein family 3
E4188_RS15665	ENOG4105DSP	amino acid AbC transporter
E4188_RS15670	ENOG4106YG3	ABC transporter
E4188_RS15680	ENOG4105F1A	Pyruvate formate-lyase
E4188_RS15685	ENOG4105BZU	Histidine kinase
E4188_RS15690	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
E4188_RS15710	ENOG4105R9B	Major Facilitator
E4188_RS15730	ENOG4105J12	Multidrug resistance protein mdtN
E4188_RS15750	ENOG4105DN3	alpha-2-macroglobulin domain protein
E4188_RS15755	ENOG4108JQB	penicillin-binding protein 1C
E4188_RS15770	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
E4188_RS15780	ENOG4105EN6	Membrane
E4188_RS15785	ENOG4105I03	Flagellin
E4188_RS15790	ENOG41063QE	flagellar protein FlaG
E4188_RS15800	ENOG4105MQ3	flagellar protein FliS
E4188_RS15825	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
E4188_RS15835	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
E4188_RS15850	ENOG4108UYE	Lactoylglutathione lyase
E4188_RS15855	ENOG4105CSM	endonuclease III
E4188_RS15865	ENOG4108UQQ	Electron transport complex
E4188_RS15870	ENOG4105D6A	Electron transport complex
E4188_RS15880	ENOG4108R3D	Electron transport complex
E4188_RS15885	ENOG4105DGN	Electron transport complex
E4188_RS15890	ENOG4108PCN	EamA-like transporter family
E4188_RS15900	ENOG4107SDU	Methyl-accepting chemotaxis
E4188_RS15910	ENOG4105RKW	reductase (By
E4188_RS15915	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
E4188_RS15920	ENOG4105CHM	Aminotransferase
E4188_RS15930	ENOG41090BQ	Glutaredoxin
E4188_RS15935	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
E4188_RS15940	ENOG4105CFI	type iii restriction protein res subunit
E4188_RS15945	ENOG4105EFX	secretion protein, HlyD family
E4188_RS15950	ENOG4105KK7	inner membrane protein YiaW
E4188_RS15955	ENOG4105EGS	Mechanosensitive ion channel
E4188_RS15965	ENOG4108NEV	two component transcriptional regulator, LytTR family
E4188_RS15970	ENOG4108HRK	Histidine kinase
E4188_RS15975	ENOG4105CPI	Metal Dependent Phosphohydrolase
E4188_RS15980	ENOG4105C0A	alcohol dehydrogenase
E4188_RS15985	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
E4188_RS15990	ENOG4107QSI	ABC, transporter
E4188_RS15995	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E4188_RS16000	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E4188_RS16005	ENOG4105C3U	ABC transporter
E4188_RS16010	ENOG4108JQ7	(ABC) transporter
E4188_RS16015	ENOG4105DU1	integral membrane protein, terc
E4188_RS16020	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
E4188_RS16030	ENOG4107QJT	sodium dicarboxylate symporter
E4188_RS16045	ENOG4105CD3	dihydroorotase
E4188_RS16055	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS16060	ENOG4105K59	histidine triad (HIT) protein
E4188_RS16095	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E4188_RS16100	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E4188_RS16110	ENOG4105CKW	Inner membrane protein yedI
E4188_RS16115	ENOG4105DPN	Oligoendopeptidase f
E4188_RS16120	ENOG4105DPN	Oligoendopeptidase f
E4188_RS16125	ENOG4105D0Y	UPF0227 protein
E4188_RS16130	ENOG4105CEP	NADH dehydrogenase
E4188_RS16140	ENOG4105EQR	Transposase IS116 IS110 IS902
E4188_RS16145	ENOG4105K8R	UPF0145 protein
E4188_RS16150	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
E4188_RS16155	ENOG4107T7U	Sulfatase
E4188_RS16165	ENOG4105CFH	Aspartokinase
E4188_RS16175	ENOG4107QZM	n-acetylglutamate synthase
E4188_RS16180	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
E4188_RS16195	ENOG4105MSB	protein, conserved in bacteria
E4188_RS16205	ENOG4105CR8	Transcriptional regulator
E4188_RS16210	ENOG4105DAA	L-lactate
E4188_RS16215	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
E4188_RS16220	ENOG4107QR9	Iron-sulfur cluster binding protein
E4188_RS16225	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
E4188_RS16260	ENOG4105F2I	Transposase
E4188_RS16280	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E4188_RS16300	ENOG4105C2C	drug resistance transporter, Bcr CflA
E4188_RS16320	ENOG4105CVN	desaturase
E4188_RS16380	ENOG4105CHH	sulfate transporter
E4188_RS16395	ENOG410600T	transposase
E4188_RS16405	ENOG4105F2I	Transposase
E4188_RS16425	ENOG4105CHR	reductase
E4188_RS16430	ENOG4105K63	Thioredoxin
E4188_RS16435	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E4188_RS16440	ENOG4107ZXU	DSBA oxidoreductase
E4188_RS16450	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4188_RS16455	ENOG4105F2I	Transposase
E4188_RS16465	ENOG4105F2I	Transposase
E4188_RS16470	ENOG4105E3S	small subunit
E4188_RS16475	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
E4188_RS16480	ENOG4105CJ5	hydrogenase 2 b cytochrome subunit
E4188_RS16485	ENOG4105DPX	Hydrogenase, large subunit
E4188_RS16490	ENOG4108USZ	hydrogenase
E4188_RS16495	ENOG4108WGS	hydrogenase 2-specific chaperone
E4188_RS16505	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E4188_RS16510	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E4188_RS16515	ENOG4105C3U	ABC transporter
E4188_RS16520	ENOG4105EFJ	Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity)
E4188_RS16525	ENOG4107RSS	Hydrogenase accessory protein HypB
E4188_RS16530	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
E4188_RS16535	ENOG4105C45	hydrogenase expression formation protein (HypE)
E4188_RS16540	ENOG4105CQS	hydrogenase expression formation protein HypD
E4188_RS16545	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
E4188_RS16555	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
E4188_RS16560	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
E4188_RS16565	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
E4188_RS16570	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
E4188_RS16580	ENOG4107RE1	Inosine-guanosine kinase
E4188_RS16585	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS16600	ENOG4105BZU	Histidine kinase
E4188_RS16605	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
E4188_RS16615	ENOG4105F3T	(LipO)protein
E4188_RS16625	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
E4188_RS16630	ENOG4105WQI	isochorismatase
E4188_RS16635	ENOG4105CEY	Amp-dependent synthetase and ligase
E4188_RS16640	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
E4188_RS16650	ENOG4105CEY	Amp-dependent synthetase and ligase
E4188_RS16660	ENOG4108TSE	Transferase
E4188_RS16665	ENOG4105E0A	ABC, transporter
E4188_RS16670	ENOG4105TVJ	transport system, permease
E4188_RS16675	ENOG4105DQ5	transport system permease protein
E4188_RS16680	ENOG4105D05	Receptor
E4188_RS16695	ENOG4105QZU	Inner membrane protein YfeZ
E4188_RS16705	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
E4188_RS16710	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
E4188_RS16715	ENOG4105BZJ	Electron transfer flavoprotein
E4188_RS16720	ENOG4105C10	Electron transfer flavoprotein
E4188_RS16725	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
E4188_RS16730	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
E4188_RS16735	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
E4188_RS16740	ENOG4105EE5	Membrane protein terC
E4188_RS16750	ENOG4105MH2	YfcL protein
E4188_RS16755	ENOG4108IQE	Amp-dependent synthetase and ligase
E4188_RS16760	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
E4188_RS16765	ENOG41067MG	lrgb family
E4188_RS16770	ENOG4105VAW	lrga family
E4188_RS16775	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
E4188_RS16785	ENOG4105CJB	Exodeoxyribonuclease I
E4188_RS16790	ENOG4105DFP	Integrase
E4188_RS16870	ENOG4106050	phage regulatory protein, rha family
E4188_RS16885	ENOG4105KSK	(crossover) junction endodeoxyribonuclease
E4188_RS16930	ENOG4105CAR	Terminase, large subunit
E4188_RS17035	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
E4188_RS17040	ENOG4105FF5	Membrane
E4188_RS17060	ENOG4105CHM	Aminotransferase
E4188_RS17065	ENOG4105ETT	transcriptional Regulator, LysR family
E4188_RS17070	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
E4188_RS17080	ENOG4105EF1	ribulokinase
E4188_RS17085	ENOG4105DMK	Periplasmic binding protein LacI transcriptional regulator
E4188_RS17095	ENOG4105CNN	ABC, transporter
E4188_RS17105	ENOG4105YK5	50S ribosomal protein L36
E4188_RS17110	ENOG4105NRA	50s ribosomal protein l31 type b
E4188_RS17115	ENOG4105CAX	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity)
E4188_RS17120	ENOG4105XEP	YhcH YjgK YiaL family protein
E4188_RS17125	ENOG4108UHU	Aldolase
E4188_RS17130	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
E4188_RS17140	ENOG4105P66	Membrane
E4188_RS17145	ENOG4105CHR	reductase
E4188_RS17165	ENOG4108VKG	metal-dependent hydrolase
E4188_RS17180	ENOG4105CEE	C4-dicarboxylate transporter
E4188_RS17190	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
E4188_RS17195	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E4188_RS17210	ENOG4105BZN	citrate synthase
E4188_RS17215	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
E4188_RS17220	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
E4188_RS17225	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
E4188_RS17230	ENOG4105E33	succinate dehydrogenase
E4188_RS17235	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
E4188_RS17240	ENOG4105C7S	Dehydrogenase
E4188_RS17245	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
E4188_RS17250	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
E4188_RS17270	ENOG4105C6N	Formate acetyltransferase
E4188_RS17275	ENOG4105TMB	Formate nitrite transporter
E4188_RS17280	ENOG4105DDY	UPF0142 protein ycaO
E4188_RS17300	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
E4188_RS17305	ENOG4105VEQ	Cold shock protein
E4188_RS17310	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
E4188_RS17315	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
E4188_RS17320	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
E4188_RS17325	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
E4188_RS17330	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
E4188_RS17335	ENOG4107MBR	17 kDa surface antigen
E4188_RS17340	ENOG4106TD9	Diguanylate cyclase
E4188_RS17345	ENOG4105C3M	thioredoxin reductase
E4188_RS17350	ENOG4105DCF	alanine dehydrogenase
E4188_RS17355	ENOG4105EW9	transcriptional regulator AsnC family
E4188_RS17360	ENOG4105CNU	cell division protein FtsK
E4188_RS17365	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
E4188_RS17370	ENOG4105D1H	recombination factor protein RarA
E4188_RS17375	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
E4188_RS17380	ENOG4105E96	Colicin v production protein
E4188_RS17385	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
E4188_RS17390	ENOG4105CS2	ec 3.2.1.21
E4188_RS17395	ENOG4105C5Y	PTS System
E4188_RS17400	ENOG4105DDV	Transcriptional regulator (LacI family
E4188_RS17405	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
E4188_RS17410	ENOG4108JQ2	peptide transport system atp-binding protein
E4188_RS17420	ENOG4108EU3	peptide transport system, permease
E4188_RS17425	ENOG4108I5W	peptide transport system, permease protein
E4188_RS17430	ENOG4108J59	Extracellular solute-binding protein, family 5
E4188_RS17435	ENOG4105E51	psp operon transcriptional activator
E4188_RS17440	ENOG41087YS	Phage shock protein A
E4188_RS17445	ENOG4105YYT	phage shock protein B
E4188_RS17455	ENOG4105CM6	amino acid regulated cytosolic protein
E4188_RS17460	ENOG4106K28	UPF0283 membrane protein
E4188_RS17465	ENOG4105MIR	Phenylalanine 4-monooxygenase
E4188_RS17470	ENOG41090A4	Pterin carbinolamine dehydratase
E4188_RS17480	ENOG4108WS1	
E4188_RS17485	ENOG4108KHX	Diguanylate cyclase
E4188_RS17490	ENOG41090EK	ompa motb domain protein
E4188_RS17495	ENOG4105D4P	Coproporphyrinogen iii oxidase
E4188_RS17500	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
E4188_RS17510	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
E4188_RS17520	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
E4188_RS17525	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
E4188_RS17545	ENOG4105FQ6	thiopurine methyltransferase
E4188_RS17550	ENOG4107QXK	peptidase
E4188_RS17555	ENOG4108BY2	phosphohistidine phosphatase
E4188_RS17565	ENOG4108IPJ	Membrane
E4188_RS17570	ENOG4108J59	Extracellular solute-binding protein, family 5
E4188_RS17575	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4188_RS17580	ENOG4108JA2	transcriptioN-repair coupling factor
E4188_RS17590	ENOG4105D60	lipoprotein releasing system transmembrane protein
E4188_RS17595	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
E4188_RS17600	ENOG4105D60	lipoprotein releasing system transmembrane protein
E4188_RS17605	ENOG4105DK2	UPF0207 protein
E4188_RS17615	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
E4188_RS17620	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
E4188_RS17625	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
E4188_RS17630	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
E4188_RS17635	ENOG4105K70	DNA-binding protein
E4188_RS17640	ENOG4105EIN	peptidylprolyl cis-trans isomerase
E4188_RS17645	ENOG4105C5H	ABC transporter
E4188_RS17650	ENOG4107QN1	sodium solute
E4188_RS17655	ENOG41062QD	Membrane
E4188_RS17660	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
E4188_RS17670	ENOG41060WC	Enoyl-CoA hydratase
E4188_RS17675	ENOG4105BZG	amino acid carrier protein
E4188_RS17690	ENOG4106HK8	GPR1 FUN34 yaaH family protein
E4188_RS17705	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
E4188_RS17715	ENOG4105E39	Enoyl-CoA hydratase
E4188_RS17725	ENOG4105C1G	acyl-Coa dehydrogenase
E4188_RS17730	ENOG4105C26	Dehydrogenase
E4188_RS17735	ENOG4105C1G	acyl-Coa dehydrogenase
E4188_RS17740	ENOG4105E39	Enoyl-CoA hydratase
E4188_RS17745	ENOG4105E39	Enoyl-CoA hydratase
E4188_RS17750	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
E4188_RS17755	ENOG4105CHR	reductase
E4188_RS17760	ENOG4105D5Q	Arginine ornithine antiporter
E4188_RS17765	ENOG4105HF0	Membrane
E4188_RS17785	ENOG4105F2I	Transposase
E4188_RS17800	ENOG4105F2I	Transposase
E4188_RS17815	ENOG410600T	transposase
E4188_RS17835	ENOG41062B0	ABC transporter, permease
E4188_RS17840	ENOG4107R9N	ABC transporter
E4188_RS17845	ENOG4105C2J	ABC transporter
E4188_RS17850	ENOG4107R5U	Periplasmic binding protein LacI transcriptional regulator
E4188_RS17855	ENOG410642W	LysR family Transcriptional regulator
E4188_RS17870	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
E4188_RS17875	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
E4188_RS17885	ENOG4105BZU	Histidine kinase
E4188_RS17890	ENOG4105DND	Transcriptional regulator
E4188_RS17895	ENOG4105CS2	ec 3.2.1.21
E4188_RS17905	ENOG4105CBN	LysR family transcriptional regulator
E4188_RS17925	ENOG410600T	transposase
E4188_RS17930	ENOG4105BZU	Histidine kinase
E4188_RS17960	ENOG4105KK4	UPF0060 membrane protein
E4188_RS17970	ENOG4105K5X	acetyltransferase
E4188_RS17975	ENOG4105C1J	atp-dependent rna helicase
E4188_RS17990	ENOG4105CPF	Cell wall formation (By similarity)
E4188_RS18000	ENOG4106IUH	DTW domain containing protein
E4188_RS18005	ENOG4105EJ9	Membrane
E4188_RS18010	ENOG4105VP0	transcriptional regulator, lysR family
E4188_RS18020	ENOG4105ECQ	AraC Family Transcriptional Regulator
E4188_RS18025	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
E4188_RS18075	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E4188_RS18080	ENOG4105PAD	Hydrolase
E4188_RS18085	ENOG4105CH2	amidohydrolase
E4188_RS18090	ENOG4105CTQ	phosphohexokinase
E4188_RS18100	ENOG4107S90	membrAne
E4188_RS18105	ENOG4106371	Methyltransferase
E4188_RS18110	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
E4188_RS18115	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
E4188_RS18120	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
E4188_RS18155	ENOG4105JAB	phenazine biosynthesis protein, phzf family
E4188_RS18165	ENOG410829K	Lysine exporter protein (Lyse ygga)
E4188_RS18185	ENOG4105CVR	type I restriction-modification system
E4188_RS18190	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
E4188_RS18220	ENOG4107TB6	phosphoglycerate mutase
E4188_RS18230	ENOG4108DG9	Smr protein MutS2
E4188_RS18235	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
E4188_RS18240	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
E4188_RS18250	ENOG4105C1J	atp-dependent rna helicase
E4188_RS18255	ENOG4105WJG	Glutathione
E4188_RS18260	ENOG4105E0U	tyrosine-specific transport protein
E4188_RS18265	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
E4188_RS18270	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
E4188_RS18275	ENOG4105DE4	1-phosphofructokinase
E4188_RS18280	ENOG4105DM4	PTS System
E4188_RS18285	ENOG4105XZD	Fe-S protein
E4188_RS18290	ENOG4105CA3	membrane-bound lytic murein transglycosylase
E4188_RS18295	ENOG4105XPH	Ferredoxin
E4188_RS18300	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E4188_RS18305	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
E4188_RS18310	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
E4188_RS18315	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
E4188_RS18320	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
E4188_RS18345	ENOG4105C22	threonyL-tRNA synthetase
E4188_RS18350	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
E4188_RS18360	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
E4188_RS18380	ENOG4105CVR	type I restriction-modification system
E4188_RS18385	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
E4188_RS18390	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
E4188_RS18395	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
E4188_RS18400	ENOG4105BZU	Histidine kinase
E4188_RS18415	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
E4188_RS18425	ENOG4105BZU	Histidine kinase
E4188_RS18430	ENOG4105ETE	Transcriptional regulator (LacI family
E4188_RS18435	ENOG4108RVA	ribokinase
E4188_RS18440	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
E4188_RS18445	ENOG4105CNN	ABC, transporter
E4188_RS18450	ENOG4105C2J	ABC transporter
E4188_RS18455	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
E4188_RS18460	ENOG4108RXX	maleylacetoacetate isomerase
E4188_RS18475	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
E4188_RS18480	ENOG4105Q9Y	Universal stress protein
E4188_RS18485	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
E4188_RS18510	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
E4188_RS18525	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
E4188_RS18535	ENOG4108ZGC	gaf domain protein
E4188_RS18540	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
E4188_RS18545	ENOG4105CN1	protease
E4188_RS18550	ENOG4105CD8	aminopeptidase N
E4188_RS18560	ENOG4105C7I	Dehydrogenase
E4188_RS18565	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
E4188_RS18570	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
E4188_RS18575	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
E4188_RS18585	ENOG4105C5H	ABC transporter
E4188_RS18595	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
E4188_RS18600	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
E4188_RS18605	ENOG4105DAN	ATP-dependent protease
E4188_RS18670	ENOG4105X2V	dna damage-inducible protein
E4188_RS18680	ENOG4105H2K	paraquat-inducible protein a
E4188_RS18685	ENOG4105DY2	Paraquat-inducible protein b
E4188_RS18690	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
E4188_RS18705	ENOG4105F8V	Hydrolase, tatD family
E4188_RS18710	ENOG4107QRG	dna polymerase iii
E4188_RS18715	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
E4188_RS18720	ENOG4105HHA	aminodeoxychorismate lyase
E4188_RS18725	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
E4188_RS18730	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
E4188_RS18735	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
E4188_RS18740	ENOG4105CHR	reductase
E4188_RS18745	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
E4188_RS18750	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
E4188_RS18755	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
E4188_RS18760	ENOG4105VGS	50s ribosomal protein l32
E4188_RS18765	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
E4188_RS18775	ENOG4108UHJ	MAF-like protein
E4188_RS18780	ENOG4108YZS	Had-superfamily hydrolase, subfamily ia, variant 1
E4188_RS18785	ENOG4105EI2	Pseudouridine synthase
E4188_RS18790	ENOG4105C03	ribonuclease
E4188_RS18795	ENOG4105CJ3	phosphate transporter
E4188_RS18800	ENOG4105DHP	deoxycytidine triphosphate deaminase
E4188_RS18805	ENOG4105DBI	uridine monophosphokinase
E4188_RS18810	ENOG4105D1F	ATP-binding protein
E4188_RS18815	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
E4188_RS18825	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
E4188_RS18830	ENOG4108N3W	hemolysin secretion protein
E4188_RS18835	ENOG4105DR4	Methyltransferase
E4188_RS18845	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
E4188_RS18850	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
E4188_RS18855	ENOG4105C5X	domain protein
E4188_RS18860	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
E4188_RS18870	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
E4188_RS18880	ENOG4105CQ7	ATP-dependent helicase
E4188_RS18890	ENOG4105WH1	Two component transcriptional regulator luxr family
E4188_RS18895	ENOG4105DWD	nucleoside recognition domain protein
E4188_RS18900	ENOG4105JQN	Transcriptional regulator
E4188_RS18905	ENOG4105EUB	pirin domain protein
E4188_RS18910	ENOG4105CHJ	isochorismatase hydrolase
E4188_RS18915	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
E4188_RS18920	ENOG4107QMP	dna polymerase iii subunits gamma and tau
E4188_RS18925	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
E4188_RS18930	ENOG4105WD1	Membrane
E4188_RS18935	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
E4188_RS18945	ENOG4105DXC	membrane
E4188_RS18955	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
E4188_RS18960	ENOG4105CEY	Amp-dependent synthetase and ligase
E4188_RS18965	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
E4188_RS18975	ENOG41072GX	Peptidase M22 Glycoprotease
E4188_RS18980	ENOG4105DVT	helicase
E4188_RS18990	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
E4188_RS18995	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
E4188_RS19000	ENOG4105CIH	Imidazole acetol-phosphate transaminase
E4188_RS19010	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
E4188_RS19015	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
E4188_RS19020	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
E4188_RS19030	ENOG4105BZU	Histidine kinase
E4188_RS19035	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
E4188_RS19040	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
E4188_RS19050	ENOG4105D29	Helix-turn-helix type 11 domain protein
E4188_RS19055	ENOG4105CEY	Amp-dependent synthetase and ligase
E4188_RS19060	ENOG4107MBR	17 kDa surface antigen
E4188_RS19075	ENOG4105EHG	Permease protein
E4188_RS19100	ENOG4108VWS	Yaeq family
E4188_RS19110	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
E4188_RS19115	ENOG4105CHU	acetyl-coa acetyltransferase
E4188_RS19120	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
E4188_RS19150	ENOG4105EMN	RNA polymerase sigma factor
E4188_RS19160	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
E4188_RS19165	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
E4188_RS19170	ENOG4105D58	Diguanylate phosphodiesterase
E4188_RS19175	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
E4188_RS19180	ENOG4105CHU	acetyl-coa acetyltransferase
E4188_RS19190	ENOG4105CK2	sodium dicarboxylate symporter
E4188_RS19195	ENOG4105NBK	UPF0345 protein
E4188_RS19200	ENOG4105EJQ	L-serine dehydratase
E4188_RS19205	ENOG4105EJQ	L-serine dehydratase
E4188_RS19210	ENOG4105CVE	Lytic murein transglycosylase
E4188_RS19215	ENOG4105VNG	YcgL domain-containing protein
E4188_RS19220	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
E4188_RS19225	ENOG4107QMS	site-determining protein
E4188_RS19230	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
E4188_RS19235	ENOG4108W5H	UPF0263 protein
E4188_RS19240	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
E4188_RS19245	ENOG4105XW2	UPF0263 protein
E4188_RS19280	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
E4188_RS19285	ENOG4108SXK	Transporter Drug Metabolite Exporter family
E4188_RS19290	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
E4188_RS19295	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
E4188_RS19305	ENOG4108R6K	riboflavin synthase, subunit alpha
E4188_RS19310	ENOG4105W1I	UPF0253 protein
E4188_RS19315	ENOG4107QI1	Mate efflux family protein
E4188_RS19345	ENOG4105CQ2	DNA polymerase
E4188_RS19355	ENOG4105EUB	pirin domain protein
E4188_RS19365	ENOG4105D1S	lipid A biosynthesis
E4188_RS19370	ENOG4105D1S	lipid A biosynthesis
E4188_RS19380	ENOG4105DUM	transcriptional regulator, lysR family
E4188_RS19390	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
E4188_RS19395	ENOG41061CK	Antibiotic biosynthesis monooxygenase
E4188_RS19400	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
E4188_RS19420	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
E4188_RS19430	ENOG4105WQ3	Rna-binding protein
E4188_RS19445	ENOG4105BZ1	(ABC) transporter
E4188_RS19450	ENOG4105BZ1	(ABC) transporter
E4188_RS19455	ENOG4105BZU	Histidine kinase
E4188_RS19460	ENOG4105K63	Thioredoxin
E4188_RS19465	ENOG4105C8P	)-transporter
E4188_RS19475	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
E4188_RS19495	ENOG4105CRQ	synthase (Component I)
E4188_RS19505	ENOG4105C44	Serine transporter
E4188_RS19510	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
E4188_RS19515	ENOG4105C9U	ATP-dependent DNA helicase RecQ
E4188_RS19520	ENOG4105CYN	Serine protein kinase
E4188_RS19525	ENOG4106AKX	UPF0229 protein
E4188_RS19530	ENOG4105ED1	spovr family
E4188_RS19535	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
E4188_RS19540	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
E4188_RS19545	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
E4188_RS19555	ENOG4105DQR	SNARE associated Golgi
E4188_RS19565	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
E4188_RS19575	ENOG4105D0C	transport protein
E4188_RS19580	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
E4188_RS19600	ENOG4108MRH	transcriptional regulatory protein
E4188_RS19605	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
E4188_RS19610	ENOG4105E2R	ROK family
E4188_RS19615	ENOG4105C8Q	Methyl-accepting chemotaxis
E4188_RS19620	ENOG4105K5B	UPF0225 protein
E4188_RS19625	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
E4188_RS19630	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
E4188_RS19635	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
E4188_RS19645	ENOG410600T	transposase
E4188_RS19660	ENOG4105JJ8	Cytochrome c nitrite reductase, pentaheme subunit
E4188_RS19665	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
E4188_RS19670	ENOG4105DVI	reductase, NrfD
E4188_RS19675	ENOG4105DA4	cytochrome c-type biogenesis protein
E4188_RS19680	ENOG4107QX9	Thiol disulfide interChange protein
E4188_RS19685	ENOG4108DMF	Cytochrome C biogenesis protein
E4188_RS19695	ENOG41061WM	D-Alanyl-D-Alanine
E4188_RS19705	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
E4188_RS19710	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
E4188_RS19725	ENOG4105W87	Cbs domain
E4188_RS19735	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
E4188_RS19740	ENOG4105DZ2	Transcriptional regulator
E4188_RS19750	ENOG4105E0K	tonB-dependent siderophore receptor
E4188_RS19755	ENOG4105UEI	Transcriptional Regulator AraC Family
E4188_RS19765	ENOG4105CR8	Transcriptional regulator
E4188_RS19770	ENOG4108RYK	Nad-dependent epimerase dehydratase
E4188_RS19785	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
E4188_RS19810	ENOG4105F2I	Transposase
E4188_RS19935	ENOG4105CAF	HipA N-terminal domain protein
E4188_RS19945	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
E4188_RS19960	ENOG4108RMJ	sensory transduction regulator
E4188_RS19970	ENOG4107104	thymidine kinase
E4188_RS19975	ENOG4107S6Z	Na H antiporter
E4188_RS19985	ENOG4108WBT	adenosyltransferase
E4188_RS19990	ENOG4105VRT	cytoplasmic protein
E4188_RS19995	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
E4188_RS20000	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
E4188_RS20015	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
E4188_RS20020	ENOG4105CFV	Tetratricopeptide repeat protein
E4188_RS20030	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
E4188_RS20035	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
E4188_RS20040	ENOG4105CAT	Cytidine monophosphate kinase
E4188_RS20045	ENOG4108JEN	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
E4188_RS20050	ENOG4105DUM	transcriptional regulator, lysR family
E4188_RS20055	ENOG4108SC4	)-transporter
E4188_RS20075	ENOG4105CFC	Transporter
E4188_RS20080	ENOG4105BZU	Histidine kinase
E4188_RS20090	ENOG4105CBN	LysR family transcriptional regulator
E4188_RS20095	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
E4188_RS20120	ENOG4107RGM	aldo keto reductase
E4188_RS20125	ENOG4105VFU	Rna-binding protein
E4188_RS20135	ENOG4105HPZ	Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity)
E4188_RS20145	ENOG4105HA9	of methanol dehydrogenase type
E4188_RS20165	ENOG4105E14	MotA TolQ exbB proton channel
E4188_RS20170	ENOG4105ER2	Ompa motb domain protein
E4188_RS20175	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4188_RS20180	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E4188_RS20185	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E4188_RS20190	ENOG4105GKE	subunit e
E4188_RS20195	ENOG4107QIZ	NADH dehydrogenase
E4188_RS20200	ENOG4108IEH	NADH dehydrogenase subunit g
E4188_RS20205	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
E4188_RS20210	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E4188_RS20215	ENOG4107UFS	subunit j
E4188_RS20220	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E4188_RS20225	ENOG4105D65	subunit l
E4188_RS20230	ENOG4105C8S	subunit m
E4188_RS20235	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
E4188_RS20240	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
E4188_RS20245	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
E4188_RS20255	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
E4188_RS20260	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
E4188_RS20265	ENOG4105N21	Membrane
E4188_RS20270	ENOG4105CUT	histidyl-tRNA synthetase
E4188_RS20275	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
E4188_RS20280	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
E4188_RS20290	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
E4188_RS20295	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
E4188_RS20300	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
E4188_RS20310	ENOG4108ZIT	Ferredoxin, 2FE-2S
E4188_RS20315	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
E4188_RS20320	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
E4188_RS20325	ENOG4108Z4V	iron-sulfur cluster assembly
E4188_RS20330	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
E4188_RS20335	ENOG4105C3J	Cysteine desulfurase
E4188_RS20340	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
E4188_RS20375	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
E4188_RS20380	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E4188_RS20385	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
E4188_RS20390	ENOG4105VIE	preprotein translocase, subunit YajC
E4188_RS20395	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
E4188_RS20400	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
E4188_RS20405	ENOG4105W87	Cbs domain
E4188_RS20410	ENOG4105D3R	alkyl hydroperoxide reductase
E4188_RS20445	ENOG4105F2I	Transposase
E4188_RS20455	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4188_RS20460	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
E4188_RS20465	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
E4188_RS20470	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
E4188_RS20475	ENOG4105D0A	hydroxylase
E4188_RS20485	ENOG4105CVR	type I restriction-modification system
E4188_RS20505	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
E4188_RS20515	ENOG4105E5M	Multidrug resistance protein D
E4188_RS20520	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
E4188_RS20525	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
E4188_RS20530	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
E4188_RS20540	ENOG4105CYM	Glutathione S-transferase
E4188_RS20555	ENOG4105ECY	inositol monophosphatase
E4188_RS20560	ENOG4105EIY	sodium-type flagellar protein motY
E4188_RS20570	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
E4188_RS20575	ENOG4105D3Y	Na H antiporter
E4188_RS20585	ENOG4105CC0	LysR family Transcriptional regulator
E4188_RS20600	ENOG4105C1J	atp-dependent rna helicase
E4188_RS20605	ENOG4105KA0	thioesterase Superfamily protein
E4188_RS20615	ENOG4105CQB	FAD linked oxidase domain protein
E4188_RS20625	ENOG4105EE5	Membrane protein terC
E4188_RS20630	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
E4188_RS20635	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
E4188_RS20640	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
E4188_RS20650	ENOG4105CAQ	asparagine synthetase
E4188_RS20660	ENOG4108RXX	maleylacetoacetate isomerase
E4188_RS20670	ENOG4105F1J	Homogentisate 1,2-dioxygenase
E4188_RS20675	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
E4188_RS20685	ENOG4108W1A	pseudouridine synthase
E4188_RS20690	ENOG4105BZU	Histidine kinase
E4188_RS20700	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
E4188_RS20705	ENOG4105CEY	Amp-dependent synthetase and ligase
E4188_RS20725	ENOG4107SP2	The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity
E4188_RS20730	ENOG4105D25	secreted protein
E4188_RS20750	ENOG4105HMI	Membrane
E4188_RS20765	ENOG4108J8C	transporter major facilitator family protein
E4188_RS20775	ENOG4105E2B	Taurine dioxygenase
E4188_RS20780	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
E4188_RS20785	ENOG4105CR4	methylisocitrate lyase
E4188_RS20790	ENOG4105BZN	citrate synthase
E4188_RS20795	ENOG4108I0Z	Aconitate hydratase
E4188_RS20800	ENOG4105C7F	AcnD-accessory protein PrpF
E4188_RS20810	ENOG4108MN8	Membrane
E4188_RS20815	ENOG4105EM2	membrane
E4188_RS20820	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
E4188_RS20825	ENOG4108S3P	Sporulation domain protein
E4188_RS20830	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
E4188_RS20835	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
E4188_RS20840	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
E4188_RS20850	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
E4188_RS20855	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
E4188_RS20860	ENOG4105YVM	Phosphoesterase, PA-phosphatase related
E4188_RS20865	ENOG4105D01	(LipO)protein
E4188_RS20885	ENOG4105DKW	ABC transporter
E4188_RS20890	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
E4188_RS20895	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
E4188_RS20905	ENOG4105C85	amino acid
E4188_RS20940	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
E4188_RS20950	ENOG4105N5T	Radical SAM Protein
E4188_RS20955	ENOG4105CBC	glutamate synthase
E4188_RS20960	ENOG4105BZ8	glutamate synthase
E4188_RS20970	ENOG4105CDA	abc transporter atp-binding protein
E4188_RS20975	ENOG4105DRP	amino acid AbC transporter
E4188_RS20980	ENOG4105EAB	amino acid AbC transporter
E4188_RS21005	ENOG4105C1J	atp-dependent rna helicase
E4188_RS21025	ENOG4107QS8	(LipO)protein
E4188_RS21035	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
E4188_RS21040	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
E4188_RS21045	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
E4188_RS21050	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
E4188_RS21060	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
E4188_RS21065	ENOG4105E66	phosphoriboisomerase A
E4188_RS21070	ENOG4108JQ1	Dehydrogenase
E4188_RS21075	ENOG41080IJ	Diacylglycerol kinase
E4188_RS21080	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
E4188_RS21085	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
E4188_RS21090	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
E4188_RS21105	ENOG4105CZX	twitching motility protein
E4188_RS21110	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
E4188_RS21130	ENOG4108ZJT	translation initiation factor, Sui1
E4188_RS21200	ENOG4105F2I	Transposase
E4188_RS21205	ENOG4105C8N	cysteinyl-tRNA synthetase
E4188_RS21210	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
E4188_RS21220	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
E4188_RS21225	ENOG4105Y3U	Transglycosylase-associated protein
E4188_RS21230	ENOG4108TGY	Glutathione S-transferase
E4188_RS21250	ENOG4107R3N	Filamentation induced by cAMP protein fic
E4188_RS21315	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
E4188_RS21320	ENOG4105WH1	Two component transcriptional regulator luxr family
E4188_RS21325	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
E4188_RS21330	ENOG4105W49	UPF0434 protein
E4188_RS21335	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
E4188_RS21340	ENOG4105BZ1	(ABC) transporter
E4188_RS21345	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
E4188_RS21360	ENOG4105D7A	ATP-binding protein
E4188_RS21365	ENOG4105CGF	Aromatic amino acid aminotransferase
E4188_RS21395	ENOG4105CVR	type I restriction-modification system
E4188_RS21400	ENOG4105DVT	helicase
E4188_RS21410	ENOG4105DGU	Histone deacetylase
E4188_RS21415	ENOG4108ISG	Major Facilitator
E4188_RS21420	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
E4188_RS21425	ENOG4105G6Z	alkaline phosphatase
E4188_RS21445	ENOG4105NXH	GreA GreB family elongation factor
E4188_RS21450	ENOG4108KX4	response regulator
E4188_RS21455	ENOG4105BZU	Histidine kinase
E4188_RS21460	ENOG4105CXY	transporter
E4188_RS21470	ENOG4105D7V	transposase
E4188_RS21485	ENOG4106TNF	Periplasmic binding protein
E4188_RS21490	ENOG4105E5Q	amino acid AbC transporter
E4188_RS21495	ENOG4105CDA	abc transporter atp-binding protein
E4188_RS21505	ENOG4105D5Q	Arginine ornithine antiporter
E4188_RS21520	ENOG4105C37	(CBS) domain
E4188_RS21525	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
E4188_RS21530	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
E4188_RS21535	ENOG4105E2Z	phosphate ABC transporter (Permease
E4188_RS21540	ENOG4105C8U	phosphate abc transporter
E4188_RS21545	ENOG4108Z6B	deaminase
E4188_RS21560	ENOG4107QP3	malate synthase g
E4188_RS21565	ENOG4108I9X	Isocitrate lyase
E4188_RS21575	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
E4188_RS21585	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
E4188_RS21590	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
E4188_RS21595	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
E4188_RS21600	ENOG4107QNR	UPF0135 protein
E4188_RS21610	ENOG4105BZU	Histidine kinase
E4188_RS21625	ENOG4105RH4	Glycine cleavage system transcriptional repressor
E4188_RS21630	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
E4188_RS21635	ENOG4105C9X	ppx gppa phosphatase
E4188_RS21655	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
E4188_RS21660	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
E4188_RS21665	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
E4188_RS21670	ENOG4105CGA	flagellar basal-body rod protein FlgG
E4188_RS21675	ENOG4108KPB	Flagellar basal-body rod protein FlgF
E4188_RS21680	ENOG4105CGA	flagellar basal-body rod protein FlgG
E4188_RS21690	ENOG4108ZC9	flagellar basal-body rod protein flgc
E4188_RS21695	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
E4188_RS21700	ENOG4105BZU	Histidine kinase
E4188_RS21705	ENOG4107R88	Chemotaxis protein (CheV)
E4188_RS21710	ENOG4107ESN	Flagella basal body P-ring formation protein flgA
E4188_RS21725	ENOG4108RE9	Phosphodiesterase
E4188_RS21730	ENOG4107QSI	ABC, transporter
E4188_RS21740	ENOG4105I08	Pseudouridine synthase
E4188_RS21750	ENOG4105D7V	transposase
E4188_RS21760	ENOG4105CPI	Metal Dependent Phosphohydrolase
E4188_RS21770	ENOG4108594	Permease of the drug metabolite transporter
E4188_RS21800	ENOG4105VEQ	Cold shock protein
E4188_RS21805	ENOG4107QSN	dihydrolipoamide acetyltransferase
E4188_RS21810	ENOG4105CPP	Dehydrogenase, E1 component
E4188_RS21815	ENOG4107RUY	(E1 component), alpha subunit
E4188_RS21830	ENOG4105KR1	Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity)
E4188_RS21840	ENOG4108YXG	UPF0502 protein
E4188_RS21855	ENOG4105E3R	(LipO)protein
E4188_RS21860	ENOG4108Q9C	Periplasmic Protein
E4188_RS21875	ENOG4107ZF2	Phosphatase
E4188_RS21880	ENOG4105DAY	polysaccharide export protein
E4188_RS21905	ENOG4107QPH	glycogen) synthase
E4188_RS21910	ENOG4105CG5	Glycosyl transferase (Group 1
E4188_RS21945	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
E4188_RS22020	ENOG4105C4R	Atp-dependent dna helicase
E4188_RS22245	ENOG4108UUM	single-stranded DNA-binding protein
E4188_RS22260	ENOG41076J9	exonuclease VIII
E4188_RS22290	ENOG4105T95	Thiol disulfide interChange protein
E4188_RS22490	ENOG4105CVR	type I restriction-modification system
E4188_RS22605	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
E4188_RS22680	ENOG4105C3F	Signal peptidase i
E4188_RS22750	ENOG4105EDV	vault protein
E4188_RS22810	ENOG4107QJE	Chromosome Partitioning Protein
E4188_RS22895	ENOG4105DZR	Type I site-specific deoxyribonuclease
E4188_RS22905	ENOG4105DFS	Conserved Protein
E4188_RS22910	ENOG4105CVR	type I restriction-modification system
E4188_RS22920	ENOG4105BZU	Histidine kinase
E4188_RS23035	ENOG4105E5H	Transposase
E4188_RS23040	ENOG4108YXQ	IS66 Orf2 family protein
E4188_RS23075	ENOG4108C33	Resolvase
E4188_RS23105	ENOG4105CPI	Metal Dependent Phosphohydrolase
E4188_RS23175	ENOG4105BZU	Histidine kinase
E4188_RS23205	ENOG4108C33	Resolvase
E4188_RS23210	ENOG4108BUD	transposase
E4188_RS23280	ENOG4105RJZ	Transcriptional regulator
E4188_RS23285	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
E4188_RS23290	ENOG4105BZS	acriflavin resistance protein
E4188_RS23295	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
E4188_RS23405	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
E4188_RS23650	ENOG4107QHF	type ii secretion system protein e
E4188_RS23690	ENOG4108YX2	DNA-binding protein
E4188_RS23730	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)