locus-tag	class	description
E4188_RS00015	COG0297	glycogen (starch) synthase activity
E4188_RS00020	COG0438	transferase activity, transferring glycosyl groups
E4188_RS00070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4188_RS00125	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4188_RS00140	COG0745	RESPONSE REGULATOR receiver
E4188_RS00155	COG1737	Transcriptional regulator
E4188_RS00160	COG0469	pyruvate kinase activity
E4188_RS00170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4188_RS00175	COG1960	acyl-CoA dehydrogenase activity
E4188_RS00185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4188_RS00215	COG5433	transposase activity
E4188_RS00225	COG3039	Transposase
E4188_RS00250	COG3657	addiction module killer protein
E4188_RS00270	COG1484	DNA-dependent DNA replication
E4188_RS00275	COG4584	PFAM Integrase catalytic
E4188_RS00290	COG3039	Transposase
E4188_RS00310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4188_RS00315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_RS00320	COG1309	transcriptional regulator
E4188_RS00335	COG1946	Acyl-CoA thioesterase
E4188_RS00345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4188_RS00355	COG0009	L-threonylcarbamoyladenylate synthase
E4188_RS00365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4188_RS00370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4188_RS00370	COG0512	Glutamine amidotransferase of anthranilate synthase
E4188_RS00375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4188_RS00380	COG0135	phosphoribosylanthranilate isomerase activity
E4188_RS00380	COG0134	indole-3-glycerol-phosphate synthase activity
E4188_RS00385	COG0133	tryptophan synthase activity
E4188_RS00390	COG0159	tryptophan synthase activity
E4188_RS00400	COG5433	transposase activity
E4188_RS00405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4188_RS00415	COG3550	peptidyl-serine autophosphorylation
E4188_RS00450	COG5507	3-demethylubiquinone-9 3-methyltransferase
E4188_RS00455	COG2814	Major facilitator Superfamily
E4188_RS00465	COG0109	protoheme IX farnesyltransferase activity
E4188_RS00470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4188_RS00475	COG1845	cytochrome c oxidase, subunit III
E4188_RS00480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4188_RS00485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4188_RS00490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4188_RS00495	COG0583	DNA-binding transcription factor activity
E4188_RS00535	COG0071	Belongs to the small heat shock protein (HSP20) family
E4188_RS00560	COG0708	Exodeoxyribonuclease III
E4188_RS00570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_RS00575	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4188_RS00590	COG0095	Lipoate-protein ligase
E4188_RS00635	COG1285	pathogenesis
E4188_RS00665	COG0484	heat shock protein binding
E4188_RS00670	COG0443	Heat shock 70 kDa protein
E4188_RS00675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4188_RS00680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4188_RS00690	COG0497	DNA recombination
E4188_RS00695	COG1227	inorganic diphosphatase activity
E4188_RS00705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_RS00710	COG1136	(ABC) transporter
E4188_RS00710	COG0577	efflux transmembrane transporter activity
E4188_RS00720	COG2375	cellular response to nickel ion
E4188_RS00725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4188_RS00730	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4188_RS00735	COG0583	DNA-binding transcription factor activity
E4188_RS00740	COG2610	gluconate transmembrane transporter activity
E4188_RS00745	COG3048	D-serine ammonia-lyase activity
E4188_RS00755	COG0538	isocitrate dehydrogenase activity
E4188_RS00760	COG2207	Transcriptional regulator
E4188_RS00765	COG1482	cell wall glycoprotein biosynthetic process
E4188_RS00785	COG5492	domain, Protein
E4188_RS00785	COG4932	domain protein
E4188_RS00800	COG0583	DNA-binding transcription factor activity
E4188_RS00805	COG4584	PFAM Integrase catalytic
E4188_RS00810	COG1484	DNA-dependent DNA replication
E4188_RS00835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4188_RS00835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4188_RS00835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_RS00845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4188_RS00865	COG0482	sulfurtransferase activity
E4188_RS00870	COG2915	High frequency lysogenization protein hflD homolog
E4188_RS00875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4188_RS00880	COG2850	peptidyl-arginine hydroxylation
E4188_RS00885	COG0469	pyruvate kinase activity
E4188_RS00890	COG3264	Mechanosensitive ion channel
E4188_RS00890	COG1196	nuclear chromosome segregation
E4188_RS00900	COG2706	6-phosphogluconolactonase activity
E4188_RS00920	COG0281	malic enzyme
E4188_RS00925	COG0746	molybdenum cofactor guanylyltransferase activity
E4188_RS00930	COG1763	Mo-molybdopterin cofactor biosynthetic process
E4188_RS00935	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4188_RS00995	COG4319	ketosteroid isomerase
E4188_RS01000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4188_RS01005	COG0083	homoserine kinase activity
E4188_RS01015	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4188_RS01020	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E4188_RS01030	COG0259	pyridoxamine-phosphate oxidase activity
E4188_RS01055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4188_RS01055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4188_RS01060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4188_RS01080	COG3088	subunit of a heme lyase
E4188_RS01080	COG4235	cytochrome complex assembly
E4188_RS01085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4188_RS01090	COG1138	Cytochrome C-type biogenesis protein
E4188_RS01095	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E4188_RS01100	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4188_RS01105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4188_RS01110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4188_RS01125	COG0835	chemotaxis
E4188_RS01130	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_RS01155	COG1192	Involved in chromosome partitioning
E4188_RS01160	COG1360	Flagellar Motor Protein
E4188_RS01165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4188_RS01170	COG2201	protein-glutamate methylesterase activity
E4188_RS01175	COG0643	Histidine kinase
E4188_RS01175	COG2198	Histidine kinase
E4188_RS01175	COG0784	Response regulator, receiver
E4188_RS01180	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4188_RS01205	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4188_RS01220	COG1684	flagellar biosynthetic protein fliR
E4188_RS01280	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4188_RS01300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4188_RS01315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4188_RS01320	COG0444	Belongs to the ABC transporter superfamily
E4188_RS01325	COG4608	Belongs to the ABC transporter superfamily
E4188_RS01335	COG2971	BadF BadG BcrA BcrD
E4188_RS01345	COG0840	transmembrane signaling receptor activity
E4188_RS01365	COG3724	N-succinylarginine dihydrolase activity
E4188_RS01370	COG0616	signal peptide processing
E4188_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_RS01380	COG0583	DNA-binding transcription factor activity
E4188_RS01390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4188_RS01400	COG0583	DNA-binding transcription factor activity
E4188_RS01410	COG1881	PFAM PEBP family protein
E4188_RS01420	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4188_RS01420	COG3408	Glycogen debranching enzyme
E4188_RS01425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4188_RS01430	COG0739	heme binding
E4188_RS01435	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4188_RS01445	COG5433	transposase activity
E4188_RS01480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4188_RS01490	COG3091	SprT-like family
E4188_RS01500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4188_RS01505	COG0189	ligase activity
E4188_RS01525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4188_RS01555	COG1115	amino acid carrier protein
E4188_RS01560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4188_RS01575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4188_RS01610	COG2912	Transglutaminase-like superfamily
E4188_RS01620	COG2890	protein-(glutamine-N5) methyltransferase activity
E4188_RS01625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4188_RS01630	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4188_RS01635	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4188_RS01640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4188_RS01650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4188_RS01655	COG0737	Belongs to the 5'-nucleotidase family
E4188_RS01660	COG0193	aminoacyl-tRNA hydrolase activity
E4188_RS01665	COG0012	GTP binding
E4188_RS01710	COG0490	domain, Protein
E4188_RS01710	COG0471	metal ion transport
E4188_RS01735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4188_RS01745	COG1012	belongs to the aldehyde dehydrogenase family
E4188_RS01755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4188_RS01770	COG0180	Tryptophanyl-tRNA synthetase
E4188_RS01780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4188_RS01785	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E4188_RS01795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4188_RS01800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4188_RS01835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E4188_RS01840	COG0583	DNA-binding transcription factor activity
E4188_RS01855	COG0583	DNA-binding transcription factor activity
E4188_RS01870	COG3121	Chaperone
E4188_RS01880	COG3121	Chaperone
E4188_RS01885	COG0739	heme binding
E4188_RS01895	COG1511	domain protein
E4188_RS01895	COG3264	Mechanosensitive ion channel
E4188_RS01900	COG0584	glycerophosphoryl diester phosphodiesterase
E4188_RS01910	COG1053	succinate dehydrogenase
E4188_RS01915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4188_RS01920	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E4188_RS01930	COG3214	Protein conserved in bacteria
E4188_RS01935	COG4106	trans-aconitate 2-methyltransferase activity
E4188_RS01945	COG1022	Amp-dependent synthetase and ligase
E4188_RS01955	COG0300	oxidoreductase activity
E4188_RS01965	COG0745	RESPONSE REGULATOR receiver
E4188_RS01970	COG0642	Histidine kinase
E4188_RS01980	COG0516	GMP reductase activity
E4188_RS01990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4188_RS01995	COG3647	Membrane
E4188_RS02005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4188_RS02015	COG2199	diguanylate cyclase activity
E4188_RS02030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4188_RS02040	COG0583	DNA-binding transcription factor activity
E4188_RS02045	COG1278	Cold shock
E4188_RS02050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4188_RS02055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4188_RS02060	COG1702	phosphate starvation-inducible protein PhoH
E4188_RS02065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4188_RS02070	COG4535	Mg2 and Co2 transporter CorC
E4188_RS02075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4188_RS02080	COG2888	peptidyl-tyrosine sulfation
E4188_RS02085	COG0495	leucyl-tRNA aminoacylation
E4188_RS02100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4188_RS02105	COG0799	negative regulation of ribosome biogenesis
E4188_RS02110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4188_RS02115	COG0768	penicillin binding
E4188_RS02120	COG0772	Belongs to the SEDS family
E4188_RS02125	COG2951	lytic endotransglycosylase activity
E4188_RS02130	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4188_RS02135	COG1686	Belongs to the peptidase S11 family
E4188_RS02140	COG2921	Belongs to the UPF0250 family
E4188_RS02145	COG0321	lipoyl(octanoyl) transferase activity
E4188_RS02150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4188_RS02160	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4188_RS02170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4188_RS02185	COG1970	mechanosensitive ion channel activity
E4188_RS02195	COG4974	Belongs to the 'phage' integrase family
E4188_RS02215	COG0312	modulator of DNA gyrase
E4188_RS02235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4188_RS02250	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4188_RS02255	COG2211	Major facilitator Superfamily
E4188_RS02260	COG1185	polyribonucleotide nucleotidyltransferase activity
E4188_RS02265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4188_RS02270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4188_RS02275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4188_RS02280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4188_RS02285	COG0195	Participates in both transcription termination and antitermination
E4188_RS02290	COG0779	Required for maturation of 30S ribosomal subunits
E4188_RS02305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4188_RS02310	COG0149	triose-phosphate isomerase activity
E4188_RS02315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4188_RS02320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4188_RS02330	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4188_RS02335	COG1534	Rna-binding protein
E4188_RS02350	COG1360	Flagellar Motor Protein
E4188_RS02355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4188_RS02360	COG1722	exodeoxyribonuclease VII activity
E4188_RS02365	COG0142	geranyltranstransferase activity
E4188_RS02370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4188_RS02390	COG4172	Belongs to the ABC transporter superfamily
E4188_RS02395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4188_RS02400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4188_RS02405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4188_RS02410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E4188_RS02425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4188_RS02425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4188_RS02430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4188_RS02445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4188_RS02455	COG2205	protein histidine kinase activity
E4188_RS02455	COG2198	Histidine kinase
E4188_RS02455	COG0784	Response regulator, receiver
E4188_RS02460	COG1879	ABC-type sugar transport system periplasmic component
E4188_RS02470	COG0745	RESPONSE REGULATOR receiver
E4188_RS02475	COG3005	denitrification pathway
E4188_RS02485	COG3381	protein complex oligomerization
E4188_RS02505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4188_RS02510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4188_RS02515	COG0511	ligase activity, forming carbon-carbon bonds
E4188_RS02520	COG0439	Biotin carboxylase
E4188_RS02525	COG3924	membrane
E4188_RS02530	COG4145	pantothenate transmembrane transporter activity
E4188_RS02535	COG2190	(PTS) system
E4188_RS02535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4188_RS02535	COG1263	PTS System
E4188_RS02540	COG0583	DNA-binding transcription factor activity
E4188_RS02545	COG0604	alcohol dehydrogenase
E4188_RS02550	COG2264	protein methyltransferase activity
E4188_RS02560	COG0778	Nitroreductase
E4188_RS02565	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4188_RS02565	COG1902	pentaerythritol trinitrate reductase activity
E4188_RS02570	COG0616	signal peptide processing
E4188_RS02590	COG3139	Protein of unknown function (DUF1315)
E4188_RS02595	COG0252	asparaginase activity
E4188_RS02600	COG0786	glutamate:sodium symporter activity
E4188_RS02610	COG5001	Diguanylate cyclase
E4188_RS02625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4188_RS02630	COG0384	phenazine biosynthesis protein PhzF
E4188_RS02635	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E4188_RS02640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4188_RS02645	COG0175	sulfate reduction
E4188_RS02650	COG2113	Glycine betaine
E4188_RS02655	COG4176	ABC-type proline glycine betaine transport system permease component
E4188_RS02660	COG4175	Glycine betaine
E4188_RS02670	COG3610	response to peptide
E4188_RS02675	COG2966	Psort location CytoplasmicMembrane, score
E4188_RS02685	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4188_RS02695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4188_RS02700	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_RS02710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4188_RS02760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4188_RS02765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4188_RS02810	COG2313	pseudouridylate synthase activity
E4188_RS02815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4188_RS02820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4188_RS02820	COG2146	nitrite reductase [NAD(P)H] activity
E4188_RS02825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4188_RS02825	COG2146	nitrite reductase [NAD(P)H] activity
E4188_RS02830	COG1116	anion transmembrane transporter activity
E4188_RS02835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4188_RS02840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4188_RS02840	COG1116	anion transmembrane transporter activity
E4188_RS02855	COG0243	molybdopterin cofactor binding
E4188_RS02880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4188_RS02900	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4188_RS02905	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4188_RS02910	COG4608	Belongs to the ABC transporter superfamily
E4188_RS02925	COG4239	(ABC) transporter, permease
E4188_RS02930	COG4174	ABC transporter (Permease)
E4188_RS02935	COG4206	TonB-dependent receptor
E4188_RS02945	COG0811	peptide transport
E4188_RS02950	COG0811	peptide transport
E4188_RS02955	COG0848	biopolymer transport protein
E4188_RS03000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4188_RS03005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4188_RS03010	COG0840	transmembrane signaling receptor activity
E4188_RS03020	COG1278	Cold shock
E4188_RS03060	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4188_RS03070	COG0688	phosphatidylethanolamine metabolic process
E4188_RS03075	COG4628	conserved protein (DUF2132)
E4188_RS03090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4188_RS03095	COG2207	Transcriptional regulator
E4188_RS03105	COG3300	MHYT domain
E4188_RS03105	COG5001	Diguanylate cyclase
E4188_RS03110	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E4188_RS03125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4188_RS03135	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4188_RS03140	COG2017	converts alpha-aldose to the beta-anomer
E4188_RS03150	COG1609	Transcriptional regulator
E4188_RS03170	COG3039	Transposase
E4188_RS03175	COG0583	DNA-binding transcription factor activity
E4188_RS03200	COG1132	(ABC) transporter
E4188_RS03210	COG2897	thiosulfate sulfurtransferase activity
E4188_RS03215	COG2066	Belongs to the glutaminase family
E4188_RS03220	COG3171	Protein conserved in bacteria
E4188_RS03225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4188_RS03230	COG2234	aminopeptidase activity
E4188_RS03230	COG4935	Belongs to the peptidase S8 family
E4188_RS03235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4188_RS03240	COG2200	EAL domain
E4188_RS03245	COG1090	epimerase
E4188_RS03250	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4188_RS03255	COG4181	ATPase activity
E4188_RS03260	COG2755	lipolytic protein G-D-S-L family
E4188_RS03265	COG0835	chemotaxis
E4188_RS03265	COG0784	Response regulator, receiver
E4188_RS03270	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4188_RS03275	COG0517	IMP dehydrogenase activity
E4188_RS03280	COG0488	(ABC) transporter
E4188_RS03290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4188_RS03320	COG3039	Transposase
E4188_RS03340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4188_RS03345	COG1376	ErfK ybiS ycfS ynhG family protein
E4188_RS03350	COG0668	transmembrane transport
E4188_RS03360	COG2731	YhcH YjgK YiaL family protein
E4188_RS03370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4188_RS03375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4188_RS03385	COG0583	DNA-binding transcription factor activity
E4188_RS03390	COG0477	Major facilitator Superfamily
E4188_RS03400	COG2985	domain, Protein
E4188_RS03400	COG0569	domain protein
E4188_RS03405	COG1272	protein, Hemolysin III
E4188_RS03410	COG0076	glutamate decarboxylase activity
E4188_RS03415	COG2917	probably involved in intracellular septation
E4188_RS03420	COG2350	Protein conserved in bacteria
E4188_RS03430	COG1555	photosystem II stabilization
E4188_RS03435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4188_RS03440	COG3104	oligopeptide transport
E4188_RS03445	COG0745	RESPONSE REGULATOR receiver
E4188_RS03475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_RS03505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_RS03515	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4188_RS03550	COG1484	DNA-dependent DNA replication
E4188_RS03555	COG4584	PFAM Integrase catalytic
E4188_RS03570	COG3293	Transposase
E4188_RS03615	COG5433	transposase activity
E4188_RS03690	COG2003	Belongs to the UPF0758 family
E4188_RS03740	COG3311	Transcriptional regulator
E4188_RS03800	COG0316	Belongs to the HesB IscA family
E4188_RS03810	COG0038	chloride channel
E4188_RS03815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4188_RS03830	COG0671	phosphoesterase, PA-phosphatase related
E4188_RS03840	COG0583	DNA-binding transcription factor activity
E4188_RS03845	COG2076	Multidrug Resistance protein
E4188_RS03860	COG0346	lactoylglutathione lyase activity
E4188_RS03865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4188_RS03870	COG1643	Atp-dependent helicase
E4188_RS03875	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E4188_RS03880	COG1489	DNA binding
E4188_RS03885	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4188_RS03890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4188_RS03895	COG0617	tRNA 3'-terminal CCA addition
E4188_RS03905	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E4188_RS03910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E4188_RS03920	COG0842	Transport permease protein
E4188_RS03925	COG1131	(ABC) transporter
E4188_RS03940	COG0163	prenyltransferase activity
E4188_RS03945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4188_RS03950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4188_RS03965	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E4188_RS03980	COG1136	(ABC) transporter
E4188_RS04010	COG3039	Transposase
E4188_RS04020	COG0529	Catalyzes the synthesis of activated sulfate
E4188_RS04025	COG0471	metal ion transport
E4188_RS04025	COG3273	potassium ion transport
E4188_RS04030	COG2895	sulfate adenylyltransferase (ATP) activity
E4188_RS04035	COG0175	sulfate reduction
E4188_RS04040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4188_RS04040	COG1648	precorrin-2 dehydrogenase activity
E4188_RS04045	COG0330	HflC and HflK could
E4188_RS04050	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4188_RS04060	COG0673	inositol 2-dehydrogenase activity
E4188_RS04070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4188_RS04075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4188_RS04080	COG3036	rescue of stalled ribosome
E4188_RS04095	COG0138	bifunctional purine biosynthesis protein purh
E4188_RS04100	COG0151	Belongs to the GarS family
E4188_RS04125	COG4584	PFAM Integrase catalytic
E4188_RS04130	COG1484	DNA-dependent DNA replication
E4188_RS04140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4188_RS04145	COG0358	DNA primase activity
E4188_RS04150	COG1610	YqeY-like protein
E4188_RS04155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4188_RS04160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4188_RS04170	COG1388	LysM domain
E4188_RS04170	COG4942	peptidase
E4188_RS04175	COG1238	metal cluster binding
E4188_RS04180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4188_RS04185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E4188_RS04190	COG0585	pseudouridine synthase activity
E4188_RS04200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4188_RS04205	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4188_RS04210	COG0148	phosphopyruvate hydratase activity
E4188_RS04215	COG0504	CTP synthase activity
E4188_RS04220	COG3956	TIGRFAM MazG family protein
E4188_RS04225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4188_RS04230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4188_RS04240	COG4807	Protein conserved in bacteria
E4188_RS04245	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4188_RS04250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4188_RS04255	COG1381	Involved in DNA repair and RecF pathway recombination
E4188_RS04265	COG0571	ribonuclease III activity
E4188_RS04270	COG0681	Belongs to the peptidase S26 family
E4188_RS04275	COG0481	GTPase activity
E4188_RS04295	COG1595	DNA-templated transcription, initiation
E4188_RS04300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4188_RS04350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4188_RS04355	COG0191	fructose-bisphosphate aldolase activity
E4188_RS04360	COG0126	phosphoglycerate kinase activity
E4188_RS04365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4188_RS04370	COG1940	carbohydrate kinase activity
E4188_RS04375	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4188_RS04385	COG4991	sh3 domain protein
E4188_RS04390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4188_RS04405	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4188_RS04415	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_RS04420	COG2982	Protein involved in outer membrane biogenesis
E4188_RS04425	COG1505	serine-type exopeptidase activity
E4188_RS04430	COG3174	membrane
E4188_RS04435	COG0110	maltose O-acetyltransferase activity
E4188_RS04450	COG3039	Transposase
E4188_RS04460	COG0165	Argininosuccinate lyase
E4188_RS04465	COG0137	argininosuccinate synthase activity
E4188_RS04475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4188_RS04480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4188_RS04490	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E4188_RS04495	COG3447	MASE1 domain protein
E4188_RS04495	COG5001	Diguanylate cyclase
E4188_RS04495	COG5002	protein histidine kinase activity
E4188_RS04530	COG0583	DNA-binding transcription factor activity
E4188_RS04535	COG1380	Effector of murein hydrolase LrgA
E4188_RS04540	COG1346	cytolysis
E4188_RS04545	COG0527	aspartate kinase activity
E4188_RS04545	COG0460	homoserine dehydrogenase
E4188_RS04550	COG0626	cystathionine gamma-synthase activity
E4188_RS04565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4188_RS04570	COG0814	amino acid
E4188_RS04575	COG1218	3'(2'),5'-bisphosphate nucleotidase
E4188_RS04580	COG0494	nUDIX hydrolase
E4188_RS04585	COG1011	Hydrolase
E4188_RS04590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4188_RS04605	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E4188_RS04615	COG3156	type II secretion system protein K
E4188_RS04625	COG4795	General secretion pathway protein
E4188_RS04630	COG2165	general secretion pathway protein
E4188_RS04640	COG2165	general secretion pathway protein
E4188_RS04645	COG1459	type II secretion system
E4188_RS04650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4188_RS04660	COG3031	protein transport across the cell outer membrane
E4188_RS04670	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4188_RS04675	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E4188_RS04695	COG3133	Outer membrane lipoprotein
E4188_RS04705	COG1392	Phosphate transport regulator
E4188_RS04710	COG0306	phosphate transporter
E4188_RS04715	COG0617	tRNA 3'-terminal CCA addition
E4188_RS04720	COG3409	Peptidoglycan-binding domain 1 protein
E4188_RS04720	COG3267	Type II secretory pathway component ExeA
E4188_RS04730	COG1194	a g-specific adenine glycosylase
E4188_RS04735	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E4188_RS04750	COG3240	lipase activity
E4188_RS04760	COG3009	Protein conserved in bacteria
E4188_RS04765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4188_RS04765	COG3008	intermembrane lipid transfer
E4188_RS04780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4188_RS04785	COG4251	negative regulation of phosphorylation
E4188_RS04785	COG3706	GGDEF domain
E4188_RS04785	COG2203	Gaf domain
E4188_RS04785	COG5001	Diguanylate cyclase
E4188_RS04790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4188_RS04795	COG2813	Specifically methylates the guanine in position
E4188_RS04800	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4188_RS04805	COG0297	glycogen (starch) synthase activity
E4188_RS04845	COG1757	Na H antiporter
E4188_RS04850	COG0583	DNA-binding transcription factor activity
E4188_RS04855	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4188_RS04860	COG3842	ATPase activity
E4188_RS04865	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4188_RS04870	COG1177	transmembrane transport
E4188_RS04875	COG1012	belongs to the aldehyde dehydrogenase family
E4188_RS04880	COG0109	protoheme IX farnesyltransferase activity
E4188_RS04885	COG1612	heme a metabolic process
E4188_RS04910	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4188_RS04915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4188_RS04920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4188_RS04925	COG1444	tRNA N-acetyltransferase activity
E4188_RS04945	COG1803	Methylglyoxal synthase
E4188_RS04960	COG0252	asparaginase activity
E4188_RS04970	COG1609	Transcriptional regulator
E4188_RS04980	COG1940	carbohydrate kinase activity
E4188_RS04985	COG1447	Phosphotransferase system cellobiose-specific component IIA
E4188_RS04990	COG2723	6-phospho-beta-galactosidase activity
E4188_RS04995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4188_RS04995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4188_RS05000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4188_RS05005	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4188_RS05020	COG1263	PTS System
E4188_RS05020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4188_RS05025	COG0366	Alpha amylase catalytic
E4188_RS05030	COG0110	maltose O-acetyltransferase activity
E4188_RS05035	COG1522	sequence-specific DNA binding
E4188_RS05040	COG5006	permease, DMT superfamily
E4188_RS05090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E4188_RS05095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E4188_RS05110	COG0477	Major facilitator Superfamily
E4188_RS05115	COG0523	cobalamin synthesis protein
E4188_RS05125	COG1280	lysine exporter protein (LysE YggA)
E4188_RS05135	COG2200	EAL domain
E4188_RS05140	COG1049	propionate catabolic process, 2-methylcitrate cycle
E4188_RS05145	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4188_RS05150	COG0840	transmembrane signaling receptor activity
E4188_RS05165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4188_RS05170	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4188_RS05175	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4188_RS05180	COG2186	Transcriptional regulator
E4188_RS05215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4188_RS05220	COG1459	type II secretion system
E4188_RS05225	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E4188_RS05235	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E4188_RS05240	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4188_RS05250	COG0653	protein targeting
E4188_RS05260	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4188_RS05265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4188_RS05270	COG0849	cell division
E4188_RS05275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4188_RS05280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4188_RS05285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4188_RS05290	COG0772	Belongs to the SEDS family
E4188_RS05295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4188_RS05300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4188_RS05305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4188_RS05310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4188_RS05315	COG0768	penicillin binding
E4188_RS05320	COG3116	cell division
E4188_RS05325	COG0275	rRNA processing
E4188_RS05330	COG2001	Belongs to the MraZ family
E4188_RS05340	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4188_RS05345	COG3107	peptidoglycan biosynthetic process
E4188_RS05350	COG0792	nuclease activity
E4188_RS05355	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4188_RS05360	COG2823	Periplasmic or secreted lipoprotein
E4188_RS05365	COG2969	positive regulation of protein catabolic process
E4188_RS05370	COG0625	glutathione transferase activity
E4188_RS05375	COG2857	Cytochrome c1
E4188_RS05380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4188_RS05385	COG0723	plastoquinol--plastocyanin reductase activity
E4188_RS05390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4188_RS05395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4188_RS05400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4188_RS05410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4188_RS05415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4188_RS05425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_RS05430	COG1660	Displays ATPase and GTPase activities
E4188_RS05435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_RS05450	COG1137	ATPase activity
E4188_RS05455	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4188_RS05460	COG3117	lipopolysaccharide transmembrane transporter activity
E4188_RS05465	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4188_RS05470	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4188_RS05470	COG0517	IMP dehydrogenase activity
E4188_RS05475	COG1127	ABC transporter
E4188_RS05480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4188_RS05485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4188_RS05490	COG2854	intermembrane phospholipid transfer
E4188_RS05500	COG5007	Belongs to the BolA IbaG family
E4188_RS05505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4188_RS05510	COG0312	modulator of DNA gyrase
E4188_RS05515	COG3028	Belongs to the UPF0307 family
E4188_RS05525	COG2926	Belongs to the UPF0265 family
E4188_RS05555	COG1396	sequence-specific DNA binding
E4188_RS05560	COG3135	benzoate transporter
E4188_RS05570	COG1522	sequence-specific DNA binding
E4188_RS05580	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E4188_RS05590	COG1546	Belongs to the CinA family
E4188_RS05590	COG1058	Belongs to the CinA family
E4188_RS05595	COG1988	membrane-bound metal-dependent
E4188_RS05605	COG0561	phosphatase activity
E4188_RS05610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4188_RS05620	COG1011	Hydrolase
E4188_RS05635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E4188_RS05640	COG0019	diaminopimelate decarboxylase activity
E4188_RS05650	COG1965	Belongs to the frataxin family
E4188_RS05655	COG0400	carboxylic ester hydrolase activity
E4188_RS05660	COG3072	Adenylate cyclase
E4188_RS05665	COG0181	hydroxymethylbilane synthase activity
E4188_RS05675	COG2959	enzyme of heme biosynthesis
E4188_RS05680	COG3071	HemY protein
E4188_RS05690	COG1494	fructose-1,6-bisphosphatase
E4188_RS05700	COG1247	-acetyltransferase
E4188_RS05720	COG0456	acetyltransferase
E4188_RS05725	COG1733	regulation of RNA biosynthetic process
E4188_RS05745	COG3932	Exopolysaccharide synthesis, ExoD
E4188_RS05750	COG3706	GGDEF domain
E4188_RS05760	COG0110	maltose O-acetyltransferase activity
E4188_RS05770	COG1943	Transposase
E4188_RS05775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4188_RS05780	COG2022	thiamine diphosphate biosynthetic process
E4188_RS05790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4188_RS05795	COG0352	thiamine-phosphate diphosphorylase activity
E4188_RS05800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E4188_RS05820	COG0745	RESPONSE REGULATOR receiver
E4188_RS05825	COG0642	Histidine kinase
E4188_RS05830	COG0189	ligase activity
E4188_RS05860	COG2321	neutral zinc metallopeptidase
E4188_RS05870	COG0477	Major facilitator Superfamily
E4188_RS05885	COG0312	modulator of DNA gyrase
E4188_RS05890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4188_RS05895	COG3164	Protein of unknown function
E4188_RS05900	COG1530	ribonuclease E activity
E4188_RS05905	COG0424	maF-like protein
E4188_RS05910	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4188_RS05915	COG1792	Involved in formation and maintenance of cell shape
E4188_RS05920	COG1077	Cell shape determining protein MreB Mrl
E4188_RS05965	COG1459	type II secretion system
E4188_RS05970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4188_RS05990	COG5433	transposase activity
E4188_RS06025	COG2200	EAL domain
E4188_RS06030	COG0387	Pfam Sodium calcium exchanger
E4188_RS06040	COG2986	histidine ammonia-lyase
E4188_RS06045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4188_RS06050	COG0010	Belongs to the arginase family
E4188_RS06055	COG1228	amidohydrolase
E4188_RS06060	COG2188	Transcriptional regulator
E4188_RS06065	COG0288	reversible hydration of carbon dioxide
E4188_RS06075	COG2177	Part of the ABC transporter FtsEX involved in
E4188_RS06080	COG2884	Cell division ATP-binding protein ftsE
E4188_RS06085	COG0552	protein localization to endoplasmic reticulum
E4188_RS06090	COG0742	ribosomal rna small subunit methyltransferase
E4188_RS06115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4188_RS06125	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4188_RS06135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4188_RS06145	COG2095	MarC family integral membrane protein
E4188_RS06155	COG1301	dicarboxylic acid transport
E4188_RS06180	COG3714	YhhN family
E4188_RS06200	COG1770	oligopeptidase
E4188_RS06215	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4188_RS06240	COG5433	transposase activity
E4188_RS06285	COG0203	ribosomal protein L17
E4188_RS06290	COG0202	RNA polymerase activity
E4188_RS06295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4188_RS06300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4188_RS06305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4188_RS06310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4188_RS06315	COG0201	protein transport
E4188_RS06320	COG0200	Binds to the 23S rRNA
E4188_RS06325	COG1841	ribosomal large subunit assembly
E4188_RS06330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4188_RS06335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4188_RS06340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4188_RS06345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4188_RS06350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4188_RS06355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4188_RS06360	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4188_RS06365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4188_RS06370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4188_RS06375	COG0255	Belongs to the universal ribosomal protein uL29 family
E4188_RS06380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4188_RS06385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4188_RS06390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4188_RS06395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4188_RS06400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4188_RS06405	COG0089	rRNA binding
E4188_RS06410	COG0088	Forms part of the polypeptide exit tunnel
E4188_RS06415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4188_RS06420	COG0051	transcription antitermination factor activity, RNA binding
E4188_RS06430	COG2205	protein histidine kinase activity
E4188_RS06435	COG0745	RESPONSE REGULATOR receiver
E4188_RS06465	COG3344	reverse transcriptase
E4188_RS06470	COG3385	transposase activity
E4188_RS06500	COG5433	transposase activity
E4188_RS06520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_RS06525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_RS06530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_RS06555	COG4584	PFAM Integrase catalytic
E4188_RS06560	COG1484	DNA-dependent DNA replication
E4188_RS06570	COG3706	GGDEF domain
E4188_RS06575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_RS06585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_RS06590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4188_RS06595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_RS06640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4188_RS06650	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_RS06660	COG5433	transposase activity
E4188_RS06680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4188_RS06705	COG2183	response to ionizing radiation
E4188_RS06720	COG0596	Alpha beta hydrolase
E4188_RS06725	COG1040	competence protein
E4188_RS06730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4188_RS06730	COG0316	Belongs to the HesB IscA family
E4188_RS06735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4188_RS06740	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E4188_RS06745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4188_RS06750	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4188_RS06755	COG4942	peptidase
E4188_RS06765	COG1609	Transcriptional regulator
E4188_RS06770	COG0800	Aldolase
E4188_RS06775	COG0129	dihydroxy-acid dehydratase activity
E4188_RS06780	COG3265	gluconokinase activity
E4188_RS06785	COG2610	gluconate transmembrane transporter activity
E4188_RS06790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4188_RS06800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4188_RS06810	COG0456	acetyltransferase
E4188_RS06820	COG1490	D-aminoacyl-tRNA deacylase activity
E4188_RS06825	COG1295	ribonuclease BN
E4188_RS06835	COG0174	glutamine synthetase
E4188_RS06845	COG3852	Histidine kinase
E4188_RS06855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4188_RS06860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4188_RS06870	COG3078	GTPase activator activity
E4188_RS06880	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4188_RS06885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4188_RS06890	COG0408	coproporphyrinogen oxidase activity
E4188_RS06895	COG0009	L-threonylcarbamoyladenylate synthase
E4188_RS06900	COG0551	DNA topoisomerase type I activity
E4188_RS06905	COG2922	Belongs to the Smg family
E4188_RS06910	COG0758	DNA mediated transformation
E4188_RS06920	COG0242	peptide deformylase activity
E4188_RS06925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4188_RS06930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4188_RS06930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4188_RS06935	COG0569	domain protein
E4188_RS06940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4188_RS06945	COG1322	Protein conserved in bacteria
E4188_RS06965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4188_RS06975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4188_RS06975	COG0519	Catalyzes the synthesis of GMP from XMP
E4188_RS06990	COG1396	sequence-specific DNA binding
E4188_RS06995	COG1012	belongs to the aldehyde dehydrogenase family
E4188_RS07005	COG2962	Rard protein
E4188_RS07015	COG1280	lysine exporter protein (LysE YggA)
E4188_RS07020	COG2391	methyltransferase activity
E4188_RS07055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4188_RS07075	COG5433	transposase activity
E4188_RS07090	COG0210	DNA helicase
E4188_RS07135	COG0583	DNA-binding transcription factor activity
E4188_RS07160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4188_RS07165	COG0385	Bile acid
E4188_RS07170	COG0531	amino acid
E4188_RS07175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4188_RS07180	COG0531	amino acid
E4188_RS07185	COG2731	YhcH YjgK YiaL family protein
E4188_RS07190	COG3250	beta-galactosidase activity
E4188_RS07195	COG1609	Transcriptional regulator
E4188_RS07235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4188_RS07240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4188_RS07240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4188_RS07245	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E4188_RS07250	COG3074	FtsZ-dependent cytokinesis
E4188_RS07260	COG1045	serine acetyltransferase
E4188_RS07270	COG0745	RESPONSE REGULATOR receiver
E4188_RS07275	COG2205	protein histidine kinase activity
E4188_RS07280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4188_RS07285	COG0534	Mate efflux family protein
E4188_RS07300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4188_RS07305	COG2937	Belongs to the GPAT DAPAT family
E4188_RS07310	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4188_RS07315	COG3161	chorismate lyase activity
E4188_RS07320	COG1580	Controls the rotational direction of flagella during chemotaxis
E4188_RS07335	COG0604	alcohol dehydrogenase
E4188_RS07355	COG3307	-O-antigen
E4188_RS07360	COG0438	transferase activity, transferring glycosyl groups
E4188_RS07365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4188_RS07380	COG1063	alcohol dehydrogenase
E4188_RS07395	COG0210	DNA helicase
E4188_RS07400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4188_RS07405	COG2166	iron-sulfur cluster assembly
E4188_RS07410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4188_RS07445	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E4188_RS07450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4188_RS07455	COG1739	Uncharacterized protein family UPF0029
E4188_RS07460	COG0006	proline dipeptidase activity
E4188_RS07465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4188_RS07470	COG1024	Enoyl-CoA hydratase
E4188_RS07470	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4188_RS07475	COG0183	Belongs to the thiolase family
E4188_RS07480	COG0745	RESPONSE REGULATOR receiver
E4188_RS07490	COG1653	transport
E4188_RS07500	COG0425	Belongs to the sulfur carrier protein TusA family
E4188_RS07505	COG0251	oxidation-reduction process
E4188_RS07510	COG2885	chlorophyll binding
E4188_RS07535	COG2818	Glycosylase
E4188_RS07540	COG0752	glycyl-tRNA synthetase alpha subunit
E4188_RS07545	COG0751	glycine-tRNA ligase activity
E4188_RS07580	COG0814	amino acid
E4188_RS07585	COG0814	amino acid
E4188_RS07590	COG3033	Beta-eliminating lyase
E4188_RS07600	COG0348	domain, Protein
E4188_RS07610	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4188_RS07615	COG0426	domain, Protein
E4188_RS07615	COG1773	rubredoxin
E4188_RS07620	COG3604	Transcriptional regulator
E4188_RS07625	COG1609	Transcriptional regulator
E4188_RS07665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4188_RS07680	COG2960	long-chain fatty acid transporting porin activity
E4188_RS07690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4188_RS07705	COG3118	belongs to the thioredoxin family
E4188_RS07710	COG0513	Belongs to the DEAD box helicase family
E4188_RS07715	COG0248	Ppx GppA phosphatase
E4188_RS07730	COG0742	ribosomal rna small subunit methyltransferase
E4188_RS07750	COG0084	hydrolase, TatD family'
E4188_RS07755	COG0805	protein transport
E4188_RS07760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4188_RS07765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4188_RS07770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4188_RS07775	COG3165	ubiquinone biosynthetic process from chorismate
E4188_RS07780	COG2226	methyltransferase
E4188_RS07785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E4188_RS07790	COG0402	S-adenosylhomocysteine deaminase activity
E4188_RS07795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4188_RS07830	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4188_RS07835	COG0848	biopolymer transport protein
E4188_RS07840	COG0811	peptide transport
E4188_RS07845	COG0811	peptide transport
E4188_RS07855	COG2771	luxR family
E4188_RS07865	COG1205	dead DEAH box helicase
E4188_RS07865	COG1111	helicase
E4188_RS07880	COG3039	Transposase
E4188_RS07920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4188_RS07925	COG1349	DNA-binding transcription factor activity
E4188_RS07930	COG0745	RESPONSE REGULATOR receiver
E4188_RS07935	COG2205	protein histidine kinase activity
E4188_RS07950	COG4452	Inner membrane protein CreD
E4188_RS07955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4188_RS07960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4188_RS07965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4188_RS07970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4188_RS07975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4188_RS07980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4188_RS07985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4188_RS07995	COG0356	it plays a direct role in the translocation of protons across the membrane
E4188_RS08005	COG1475	DNA binding
E4188_RS08010	COG1192	Involved in chromosome partitioning
E4188_RS08015	COG0357	Ribosomal RNA small subunit methyltransferase G
E4188_RS08020	COG0445	tRNA wobble uridine modification
E4188_RS08025	COG0716	FMN binding
E4188_RS08030	COG4774	siderophore transport
E4188_RS08035	COG4615	Cyclic peptide transporter
E4188_RS08040	COG1120	ATPase activity
E4188_RS08045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4188_RS08050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4188_RS08060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4188_RS08065	COG0706	membrane insertase activity
E4188_RS08070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4188_RS08075	COG0594	ribonuclease P activity
E4188_RS08080	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4188_RS08100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4188_RS08105	COG0592	DNA-directed DNA polymerase activity
E4188_RS08115	COG0187	DNA topoisomerase II activity
E4188_RS08125	COG2378	regulation of single-species biofilm formation
E4188_RS08135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4188_RS08140	COG0071	Belongs to the small heat shock protein (HSP20) family
E4188_RS08145	COG0071	Belongs to the small heat shock protein (HSP20) family
E4188_RS08150	COG3977	Valine--pyruvate aminotransferase
E4188_RS08165	COG2814	Major facilitator Superfamily
E4188_RS08170	COG0745	RESPONSE REGULATOR receiver
E4188_RS08175	COG2205	protein histidine kinase activity
E4188_RS08195	COG1733	regulation of RNA biosynthetic process
E4188_RS08200	COG2267	carboxylic ester hydrolase activity
E4188_RS08205	COG0604	alcohol dehydrogenase
E4188_RS08210	COG0300	oxidoreductase activity
E4188_RS08215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4188_RS08220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_RS08220	COG4191	Histidine kinase
E4188_RS08225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4188_RS08230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_RS08235	COG1309	transcriptional regulator
E4188_RS08265	COG0561	phosphatase activity
E4188_RS08270	COG2267	carboxylic ester hydrolase activity
E4188_RS08275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4188_RS08280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4188_RS08285	COG1758	RNA polymerase activity
E4188_RS08295	COG0859	PFAM glycosyl transferase family 9
E4188_RS08300	COG3642	lipopolysaccharide core region biosynthetic process
E4188_RS08340	COG0589	response to stress
E4188_RS08345	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4188_RS08350	COG3706	GGDEF domain
E4188_RS08355	COG1528	Iron-storage protein
E4188_RS08360	COG2081	HI0933 family
E4188_RS08365	COG2223	nitrite transmembrane transporter activity
E4188_RS08375	COG3275	phosphorelay sensor kinase activity
E4188_RS08380	COG3279	Response regulator of the LytR AlgR family
E4188_RS08385	COG2223	nitrite transmembrane transporter activity
E4188_RS08390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4188_RS08400	COG4206	TonB-dependent receptor
E4188_RS08405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4188_RS08435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4188_RS08435	COG1042	CoA-binding domain protein
E4188_RS08435	COG0045	succinate-CoA ligase (ADP-forming) activity
E4188_RS08445	COG0583	DNA-binding transcription factor activity
E4188_RS08450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4188_RS08455	COG0166	Belongs to the GPI family
E4188_RS08465	COG0668	transmembrane transport
E4188_RS08470	COG1309	transcriptional regulator
E4188_RS08480	COG0756	dUTP diphosphatase activity
E4188_RS08485	COG3039	Transposase
E4188_RS08510	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4188_RS08515	COG1538	Outer membrane efflux protein
E4188_RS08520	COG1484	DNA-dependent DNA replication
E4188_RS08525	COG4584	PFAM Integrase catalytic
E4188_RS08545	COG0745	RESPONSE REGULATOR receiver
E4188_RS08595	COG2132	Multicopper oxidase
E4188_RS08605	COG3039	Transposase
E4188_RS08620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4188_RS08625	COG2003	Belongs to the UPF0758 family
E4188_RS08630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4188_RS08635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4188_RS08645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4188_RS08650	COG2990	Protein conserved in bacteria
E4188_RS08655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4188_RS08660	COG0859	PFAM glycosyl transferase family 9
E4188_RS08665	COG0463	Glycosyl transferase, family 2
E4188_RS08670	COG0859	PFAM glycosyl transferase family 9
E4188_RS08675	COG1519	Transferase
E4188_RS08685	COG1561	YicC-like family, N-terminal region
E4188_RS08690	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4188_RS08695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4188_RS08705	COG0789	Transcriptional regulator
E4188_RS08710	COG3706	GGDEF domain
E4188_RS08710	COG5001	Diguanylate cyclase
E4188_RS08710	COG4251	negative regulation of phosphorylation
E4188_RS08710	COG2203	Gaf domain
E4188_RS08715	COG3084	Protein conserved in bacteria
E4188_RS08725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4188_RS08730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4188_RS08735	COG3639	organic phosphonate transmembrane transporter activity
E4188_RS08740	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4188_RS08745	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4188_RS08755	COG1335	isochorismatase
E4188_RS08765	COG1683	Conserved Protein
E4188_RS08770	COG0204	Acyl-transferase
E4188_RS08775	COG0204	Acyl-transferase
E4188_RS08780	COG0606	chelatase, subunit chli
E4188_RS08790	COG3978	acetolactate synthase activity
E4188_RS08800	COG0129	dihydroxy-acid dehydratase activity
E4188_RS08825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4188_RS08830	COG0254	rRNA binding
E4188_RS08835	COG0702	epimerase
E4188_RS08840	COG0281	malic enzyme
E4188_RS08850	COG2205	protein histidine kinase activity
E4188_RS08855	COG0745	RESPONSE REGULATOR receiver
E4188_RS08860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4188_RS08875	COG0366	Alpha amylase catalytic
E4188_RS08890	COG0443	Heat shock 70 kDa protein
E4188_RS08895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4188_RS08900	COG3045	CreA protein
E4188_RS08920	COG0174	glutamine synthetase
E4188_RS08940	COG3842	ATPase activity
E4188_RS08945	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4188_RS08950	COG1177	transmembrane transport
E4188_RS08955	COG2258	MOSC domain
E4188_RS08975	COG2050	protein possibly involved in aromatic compounds catabolism
E4188_RS08980	COG0514	ATP-dependent DNA helicase (RecQ)
E4188_RS08990	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4188_RS09000	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4188_RS09005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4188_RS09010	COG2239	Acts as a magnesium transporter
E4188_RS09015	COG1648	precorrin-2 dehydrogenase activity
E4188_RS09015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4188_RS09020	COG2116	formate transmembrane transporter activity
E4188_RS09035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4188_RS09040	COG0842	Transport permease protein
E4188_RS09045	COG0842	Transport permease protein
E4188_RS09050	COG1131	(ABC) transporter
E4188_RS09055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_RS09075	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4188_RS09080	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4188_RS09090	COG0018	arginyl-trna synthetase
E4188_RS09100	COG1595	DNA-templated transcription, initiation
E4188_RS09105	COG3806	Anti-sigma factor
E4188_RS09110	COG1968	undecaprenyl-diphosphatase activity
E4188_RS09115	COG0667	Aldo Keto reductase
E4188_RS09120	COG2017	converts alpha-aldose to the beta-anomer
E4188_RS09125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4188_RS09135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4188_RS09140	COG1609	Transcriptional regulator
E4188_RS09145	COG3250	beta-galactosidase activity
E4188_RS09160	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4188_RS09190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4188_RS09195	COG1288	antiporter activity
E4188_RS09200	COG1438	arginine binding
E4188_RS09205	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4188_RS09210	COG0540	Belongs to the ATCase OTCase family
E4188_RS09240	COG3040	lipid binding
E4188_RS09245	COG2207	Transcriptional regulator
E4188_RS09250	COG1979	alcohol dehydrogenase
E4188_RS09255	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4188_RS09260	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4188_RS09265	COG3681	Belongs to the UPF0597 family
E4188_RS09275	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4188_RS09280	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4188_RS09285	COG0564	pseudouridine synthase activity
E4188_RS09295	COG0542	response to heat
E4188_RS09300	COG2502	aspartate--ammonia ligase
E4188_RS09305	COG1522	sequence-specific DNA binding
E4188_RS09315	COG5413	integral membrane protein
E4188_RS09320	COG0517	IMP dehydrogenase activity
E4188_RS09320	COG0516	GMP reductase activity
E4188_RS09340	COG2205	protein histidine kinase activity
E4188_RS09350	COG2204	response regulator
E4188_RS09365	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4188_RS09380	COG0745	RESPONSE REGULATOR receiver
E4188_RS09385	COG2205	protein histidine kinase activity
E4188_RS09395	COG0243	molybdopterin cofactor binding
E4188_RS09400	COG3005	denitrification pathway
E4188_RS09405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4188_RS09410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4188_RS09415	COG0569	domain protein
E4188_RS09420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4188_RS09445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4188_RS09460	COG0250	Participates in transcription elongation, termination and antitermination
E4188_RS09465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4188_RS09470	COG0081	regulation of translation
E4188_RS09475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4188_RS09480	COG0222	ribosome binding
E4188_RS09485	COG0085	RNA polymerase activity
E4188_RS09490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4188_RS09495	COG2964	Protein conserved in bacteria
E4188_RS09515	COG2168	tRNA wobble position uridine thiolation
E4188_RS09520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4188_RS09525	COG0049	tRNA binding
E4188_RS09530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4188_RS09535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4188_RS09540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4188_RS09575	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E4188_RS09580	COG2252	PERMEase
E4188_RS09585	COG2376	Dihydroxyacetone kinase
E4188_RS09590	COG1461	Dihydroxyacetone kinase
E4188_RS09605	COG3284	Transcriptional regulator
E4188_RS09615	COG0628	permease
E4188_RS09640	COG0753	catalase activity
E4188_RS09645	COG0456	acetyltransferase
E4188_RS09645	COG0454	-acetyltransferase
E4188_RS09665	COG2203	Gaf domain
E4188_RS09665	COG2199	diguanylate cyclase activity
E4188_RS09675	COG3842	ATPase activity
E4188_RS09685	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4188_RS09710	COG0583	DNA-binding transcription factor activity
E4188_RS09720	COG1741	Belongs to the pirin family
E4188_RS09725	COG2259	Doxx family
E4188_RS09730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4188_RS09735	COG1074	ATP-dependent DNA helicase activity
E4188_RS09740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4188_RS09760	COG0346	lactoylglutathione lyase activity
E4188_RS09770	COG0004	ammonium transporteR
E4188_RS09775	COG0347	Belongs to the P(II) protein family
E4188_RS09780	COG3706	GGDEF domain
E4188_RS09800	COG0745	RESPONSE REGULATOR receiver
E4188_RS09805	COG2205	protein histidine kinase activity
E4188_RS09810	COG1278	Cold shock
E4188_RS09835	COG1396	sequence-specific DNA binding
E4188_RS09865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4188_RS09905	COG2197	response regulator
E4188_RS09910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4188_RS09915	COG3047	cAMP biosynthetic process
E4188_RS09965	COG4221	oxidoreductase activity
E4188_RS09980	COG1979	alcohol dehydrogenase
E4188_RS09990	COG2873	o-acetylhomoserine
E4188_RS10020	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4188_RS10030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4188_RS10035	COG2949	membrane
E4188_RS10040	COG3291	Pkd domain containing protein
E4188_RS10045	COG0318	PFAM AMP-dependent synthetase and ligase
E4188_RS10050	COG1441	menaquinone biosynthetic process
E4188_RS10055	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E4188_RS10060	COG0596	Alpha beta hydrolase
E4188_RS10065	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E4188_RS10070	COG1169	isochorismate synthase
E4188_RS10075	COG1575	Belongs to the MenA family. Type 1 subfamily
E4188_RS10100	COG0513	Belongs to the DEAD box helicase family
E4188_RS10105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4188_RS10135	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_RS10140	COG1671	Belongs to the UPF0178 family
E4188_RS10165	COG3722	fumarate hydratase activity
E4188_RS10170	COG0246	Mannitol dehydrogenase
E4188_RS10175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_RS10175	COG2213	PTS system mannitol-specific
E4188_RS10180	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E4188_RS10195	COG2771	luxR family
E4188_RS10210	COG1560	Kdo2-lipid A biosynthetic process
E4188_RS10215	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4188_RS10215	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4188_RS10220	COG1538	Outer membrane efflux protein
E4188_RS10225	COG0494	nUDIX hydrolase
E4188_RS10230	COG3151	Protein conserved in bacteria
E4188_RS10240	COG3150	esterase
E4188_RS10245	COG1051	belongs to the nudix hydrolase family
E4188_RS10335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4188_RS10355	COG0204	Acyl-transferase
E4188_RS10360	COG1842	Phage shock protein A
E4188_RS10375	COG2827	Endonuclease containing a URI domain
E4188_RS10380	COG2962	Rard protein
E4188_RS10385	COG1573	uracil-dna glycosylase
E4188_RS10395	COG0583	DNA-binding transcription factor activity
E4188_RS10400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4188_RS10405	COG1121	(ABC) transporter
E4188_RS10410	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E4188_RS10430	COG0739	heme binding
E4188_RS10440	COG3068	Protein conserved in bacteria
E4188_RS10460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4188_RS10470	COG1546	Belongs to the CinA family
E4188_RS10475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4188_RS10485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4188_RS10490	COG0527	aspartate kinase activity
E4188_RS10495	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4188_RS10530	COG1686	Belongs to the peptidase S11 family
E4188_RS10535	COG0586	Pfam SNARE associated Golgi protein
E4188_RS10540	COG1253	flavin adenine dinucleotide binding
E4188_RS10555	COG2927	DNA polymerase III (CHI subunit)
E4188_RS10560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4188_RS10565	COG0795	lipopolysaccharide-transporting ATPase activity
E4188_RS10570	COG0795	lipopolysaccharide-transporting ATPase activity
E4188_RS10590	COG0004	ammonium transporteR
E4188_RS10595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4188_RS10615	COG0084	hydrolase, TatD family'
E4188_RS10620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4188_RS10630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4188_RS10635	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4188_RS10640	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4188_RS10655	COG3064	Membrane
E4188_RS10665	COG0560	Phosphoserine phosphatase
E4188_RS10680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4188_RS10690	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E4188_RS10695	COG0776	regulation of translation
E4188_RS10710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4188_RS10715	COG0735	belongs to the Fur family
E4188_RS10735	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4188_RS10740	COG0513	Belongs to the DEAD box helicase family
E4188_RS10745	COG3022	response to hydroperoxide
E4188_RS10760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4188_RS10765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4188_RS10770	COG0762	integral membrane protein
E4188_RS10775	COG1872	DUF167
E4188_RS10795	COG3112	Uncharacterised protein family (UPF0231)
E4188_RS10800	COG3835	regulator
E4188_RS10805	COG2610	gluconate transmembrane transporter activity
E4188_RS10810	COG1929	Belongs to the glycerate kinase type-1 family
E4188_RS10825	COG0583	DNA-binding transcription factor activity
E4188_RS10830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4188_RS10845	COG0347	Belongs to the P(II) protein family
E4188_RS10850	COG1840	ABC-type Fe3 transport system, periplasmic component
E4188_RS10860	COG3842	ATPase activity
E4188_RS10865	COG2837	iron assimilation
E4188_RS10870	COG1438	arginine binding
E4188_RS10875	COG1126	abc transporter atp-binding protein
E4188_RS10880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_RS10885	COG4215	(ABC) transporter
E4188_RS10890	COG4160	amino acid transport
E4188_RS10895	COG0039	L-malate dehydrogenase activity
E4188_RS10910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4188_RS10910	COG1017	nitric oxide dioxygenase activity
E4188_RS10920	COG4536	flavin adenine dinucleotide binding
E4188_RS10925	COG4137	Cytochrome C assembly protein
E4188_RS10930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4188_RS10935	COG0228	four-way junction DNA binding
E4188_RS10940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4188_RS10945	COG0336	Belongs to the RNA methyltransferase TrmD family
E4188_RS10950	COG0335	large ribosomal subunit rRNA binding
E4188_RS10965	COG1051	belongs to the nudix hydrolase family
E4188_RS10975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4188_RS10985	COG4974	Belongs to the 'phage' integrase family
E4188_RS11010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4188_RS11015	COG3039	Transposase
E4188_RS11025	COG2194	sulfuric ester hydrolase activity
E4188_RS11035	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4188_RS11040	COG5642	Protein of unknown function (DUF2384)
E4188_RS11065	COG5433	transposase activity
E4188_RS11085	COG4584	PFAM Integrase catalytic
E4188_RS11090	COG1484	DNA-dependent DNA replication
E4188_RS11100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4188_RS11110	COG0583	DNA-binding transcription factor activity
E4188_RS11115	COG0640	Transcriptional regulator
E4188_RS11120	COG0268	Binds directly to 16S ribosomal RNA
E4188_RS11125	COG0728	peptidoglycan biosynthetic process
E4188_RS11130	COG0196	riboflavin kinase activity
E4188_RS11135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4188_RS11140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4188_RS11145	COG1047	Peptidyl-prolyl cis-trans
E4188_RS11150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4188_RS11180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4188_RS11180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4188_RS11195	COG1854	S-ribosylhomocysteine lyase activity
E4188_RS11200	COG3706	GGDEF domain
E4188_RS11205	COG0557	exoribonuclease II activity
E4188_RS11210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4188_RS11220	COG2153	protein acetylation
E4188_RS11235	COG1914	H( )-stimulated, divalent metal cation uptake system
E4188_RS11240	COG0360	Binds together with S18 to 16S ribosomal RNA
E4188_RS11245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4188_RS11250	COG0359	binds to the 23S rRNA
E4188_RS11280	COG1064	alcohol dehydrogenase
E4188_RS11285	COG1238	metal cluster binding
E4188_RS11290	COG0612	Peptidase, M16
E4188_RS11295	COG2918	glutathione biosynthetic process
E4188_RS11300	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4188_RS11305	COG1027	Aspartate ammonia-lyase
E4188_RS11310	COG3030	protein affecting phage T7 exclusion by the F plasmid
E4188_RS11315	COG0534	Mate efflux family protein
E4188_RS11320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4188_RS11325	COG0459	protein refolding
E4188_RS11345	COG0564	pseudouridine synthase activity
E4188_RS11350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4188_RS11380	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4188_RS11390	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4188_RS11395	COG4208	sulfate ABC transporter
E4188_RS11400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4188_RS11405	COG0583	DNA-binding transcription factor activity
E4188_RS11415	COG3397	chitin binding
E4188_RS11420	COG0840	transmembrane signaling receptor activity
E4188_RS11445	COG1328	CTP reductase activity
E4188_RS11450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4188_RS11465	COG1448	Aminotransferase
E4188_RS11490	COG1215	transferase activity, transferring glycosyl groups
E4188_RS11500	COG3118	belongs to the thioredoxin family
E4188_RS11500	COG0457	Tetratricopeptide repeat
E4188_RS11535	COG0513	Belongs to the DEAD box helicase family
E4188_RS11555	COG0840	transmembrane signaling receptor activity
E4188_RS11565	COG4166	transmembrane transport
E4188_RS11580	COG1024	Enoyl-CoA hydratase
E4188_RS11595	COG4221	oxidoreductase activity
E4188_RS11600	COG0442	prolyl-tRNA aminoacylation
E4188_RS11605	COG0632	four-way junction helicase activity
E4188_RS11610	COG2255	four-way junction helicase activity
E4188_RS11620	COG1271	oxidase subunit
E4188_RS11625	COG1294	oxidase, subunit
E4188_RS11630	COG4890	Cyd operon protein YbgT
E4188_RS11635	COG3790	cyd operon protein YbgE
E4188_RS11640	COG0824	Thioesterase
E4188_RS11645	COG0811	peptide transport
E4188_RS11660	COG0823	Involved in the tonB-independent uptake of proteins
E4188_RS11665	COG2885	chlorophyll binding
E4188_RS11670	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4188_RS11745	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4188_RS11755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4188_RS11760	COG1640	4-alpha-glucanotransferase
E4188_RS11765	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4188_RS11790	COG2130	NADP-dependent
E4188_RS11795	COG1846	Transcriptional regulator
E4188_RS11825	COG0561	phosphatase activity
E4188_RS11840	COG0733	neurotransmitter:sodium symporter activity
E4188_RS11845	COG0733	neurotransmitter:sodium symporter activity
E4188_RS11860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4188_RS11875	COG1794	racemase activity, acting on amino acids and derivatives
E4188_RS11885	COG1022	Amp-dependent synthetase and ligase
E4188_RS11895	COG0456	acetyltransferase
E4188_RS11910	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4188_RS11915	COG5001	Diguanylate cyclase
E4188_RS11915	COG3300	MHYT domain
E4188_RS11925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4188_RS11935	COG1902	pentaerythritol trinitrate reductase activity
E4188_RS11955	COG2957	Belongs to the agmatine deiminase family
E4188_RS11960	COG0154	amidase activity
E4188_RS11970	COG3039	Transposase
E4188_RS11990	COG0513	Belongs to the DEAD box helicase family
E4188_RS11995	COG3706	GGDEF domain
E4188_RS12005	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E4188_RS12065	COG1484	DNA-dependent DNA replication
E4188_RS12070	COG4584	PFAM Integrase catalytic
E4188_RS12085	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4188_RS12090	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E4188_RS12095	COG1178	ABC-type Fe3 transport system permease component
E4188_RS12100	COG4143	(ABC) transporter
E4188_RS12115	COG0066	3-isopropylmalate dehydratase activity
E4188_RS12120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E4188_RS12125	COG0473	3-isopropylmalate dehydrogenase activity
E4188_RS12130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4188_RS12140	COG0671	phosphoesterase, PA-phosphatase related
E4188_RS12145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4188_RS12155	COG0028	Belongs to the TPP enzyme family
E4188_RS12160	COG0440	acetolactate synthase activity
E4188_RS12165	COG0280	phosphate acetyltransferase
E4188_RS12165	COG0857	belongs to the CobB CobQ family
E4188_RS12170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4188_RS12180	COG3013	Belongs to the UPF0304 family
E4188_RS12185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4188_RS12190	COG2716	regulation of RNA biosynthetic process
E4188_RS12195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4188_RS12200	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4188_RS12205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4188_RS12240	COG5002	protein histidine kinase activity
E4188_RS12240	COG0784	Response regulator, receiver
E4188_RS12240	COG2198	Histidine kinase
E4188_RS12245	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4188_RS12280	COG0840	transmembrane signaling receptor activity
E4188_RS12290	COG1464	Belongs to the NlpA lipoprotein family
E4188_RS12295	COG2011	ABC-type metal ion transport system permease component
E4188_RS12300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4188_RS12320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4188_RS12320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4188_RS12325	COG0802	atpase or kinase
E4188_RS12335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4188_RS12340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4188_RS12345	COG1923	regulation of RNA biosynthetic process
E4188_RS12350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4188_RS12355	COG0330	HflC and HflK could
E4188_RS12360	COG0330	HflC and HflK could
E4188_RS12365	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E4188_RS12370	COG0142	geranyltranstransferase activity
E4188_RS12375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4188_RS12380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4188_RS12385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4188_RS12395	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E4188_RS12400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4188_RS12410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4188_RS12415	COG2967	ApaG domain
E4188_RS12420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4188_RS12425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4188_RS12435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E4188_RS12440	COG3178	'Phosphotransferase
E4188_RS12445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4188_RS12450	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4188_RS12460	COG2252	PERMEase
E4188_RS12470	COG0488	(ABC) transporter
E4188_RS12475	COG0741	lytic transglycosylase activity
E4188_RS12480	COG0463	Glycosyl transferase, family 2
E4188_RS12490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4188_RS12515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4188_RS12525	COG3721	Heme iron utilization protein
E4188_RS12530	COG0748	coenzyme F420 binding
E4188_RS12555	COG2814	Major facilitator Superfamily
E4188_RS12560	COG2205	protein histidine kinase activity
E4188_RS12590	COG1765	OsmC-like protein
E4188_RS12605	COG3954	Phosphoribulokinase
E4188_RS12610	COG3089	Belongs to the UPF0270 family
E4188_RS12620	COG0429	hydrolase of the alpha beta-hydrolase fold
E4188_RS12625	COG0835	chemotaxis
E4188_RS12625	COG0784	Response regulator, receiver
E4188_RS12635	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4188_RS12640	COG1047	Peptidyl-prolyl cis-trans
E4188_RS12655	COG0545	Peptidyl-prolyl cis-trans isomerase
E4188_RS12680	COG0737	Belongs to the 5'-nucleotidase family
E4188_RS12695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4188_RS12700	COG0506	proline dehydrogenase activity
E4188_RS12700	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4188_RS12700	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4188_RS12710	COG0114	fumarate hydratase activity
E4188_RS12750	COG2203	Gaf domain
E4188_RS12750	COG2200	EAL domain
E4188_RS12750	COG2199	diguanylate cyclase activity
E4188_RS12785	COG1280	lysine exporter protein (LysE YggA)
E4188_RS12795	COG0826	peptidase U32
E4188_RS12805	COG3813	Protein conserved in bacteria
E4188_RS12825	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4188_RS12850	COG0300	oxidoreductase activity
E4188_RS12870	COG2610	gluconate transmembrane transporter activity
E4188_RS12875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4188_RS12880	COG3622	Belongs to the hyi family
E4188_RS12885	COG0235	Class ii aldolase
E4188_RS12890	COG3395	kinase activity
E4188_RS12895	COG2084	Dehydrogenase
E4188_RS12900	COG1349	DNA-binding transcription factor activity
E4188_RS12910	COG2133	pyrroloquinoline quinone binding
E4188_RS12925	COG1609	Transcriptional regulator
E4188_RS12945	COG1175	transmembrane transport
E4188_RS12960	COG3940	Belongs to the glycosyl hydrolase 43 family
E4188_RS12975	COG4580	involved in the transport of maltose and maltodextrins
E4188_RS12980	COG5433	transposase activity
E4188_RS12985	COG4580	involved in the transport of maltose and maltodextrins
E4188_RS13010	COG0077	Prephenate dehydratase
E4188_RS13010	COG1605	Chorismate mutase
E4188_RS13035	COG3272	Protein of unknown function (DUF1722)
E4188_RS13040	COG0789	Transcriptional regulator
E4188_RS13045	COG0415	Belongs to the DNA photolyase family
E4188_RS13055	COG0300	oxidoreductase activity
E4188_RS13070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4188_RS13095	COG0783	Belongs to the Dps family
E4188_RS13100	COG1151	hydroxylamine reductase activity
E4188_RS13105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4188_RS13110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4188_RS13135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4188_RS13145	COG0798	PFAM Bile acid sodium symporter
E4188_RS13150	COG1393	Belongs to the ArsC family
E4188_RS13175	COG0659	secondary active sulfate transmembrane transporter activity
E4188_RS13180	COG2771	luxR family
E4188_RS13190	COG3501	Rhs element vgr protein
E4188_RS13205	COG3039	Transposase
E4188_RS13230	COG1666	GTP binding
E4188_RS13235	COG3248	Nucleoside-binding outer membrane protein
E4188_RS13240	COG2211	Major facilitator Superfamily
E4188_RS13250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4188_RS13260	COG2813	Specifically methylates the guanine in position
E4188_RS13265	COG0271	Belongs to the BolA IbaG family
E4188_RS13270	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4188_RS13275	COG1805	sodium ion transport
E4188_RS13280	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4188_RS13285	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4188_RS13290	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E4188_RS13295	COG2871	sodium ion transport
E4188_RS13300	COG1477	protein flavinylation
E4188_RS13315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4188_RS13320	COG0840	transmembrane signaling receptor activity
E4188_RS13325	COG0583	DNA-binding transcription factor activity
E4188_RS13335	COG2363	Small membrane protein
E4188_RS13340	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E4188_RS13350	COG0473	3-isopropylmalate dehydrogenase activity
E4188_RS13355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4188_RS13360	COG1611	Belongs to the LOG family
E4188_RS13365	COG3706	GGDEF domain
E4188_RS13375	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4188_RS13375	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E4188_RS13385	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E4188_RS13410	COG3098	single-species biofilm formation
E4188_RS13415	COG0564	pseudouridine synthase activity
E4188_RS13425	COG4580	involved in the transport of maltose and maltodextrins
E4188_RS13435	COG1263	PTS System
E4188_RS13435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4188_RS13445	COG2171	N-acyltransferase activity
E4188_RS13450	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E4188_RS13455	COG0024	Methionine aminopeptidase
E4188_RS13460	COG0052	Belongs to the universal ribosomal protein uS2 family
E4188_RS13465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4188_RS13470	COG0528	UMP kinase activity
E4188_RS13475	COG0233	cytoplasmic translational termination
E4188_RS13480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4188_RS13485	COG0575	Belongs to the CDS family
E4188_RS13490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4188_RS13495	COG0750	zinc metalloprotease
E4188_RS13510	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4188_RS13515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4188_RS13520	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4188_RS13525	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4188_RS13530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4188_RS13540	COG0825	malonyl-CoA metabolic process
E4188_RS13550	COG0583	DNA-binding transcription factor activity
E4188_RS13555	COG0814	amino acid
E4188_RS13560	COG0531	amino acid
E4188_RS13580	COG3590	peptidase
E4188_RS13590	COG3706	GGDEF domain
E4188_RS13625	COG0366	Alpha amylase catalytic
E4188_RS13640	COG0463	Glycosyl transferase, family 2
E4188_RS13655	COG2989	Protein conserved in bacteria
E4188_RS13660	COG3108	Peptidase M15
E4188_RS13670	COG2860	membrane
E4188_RS13680	COG1196	nuclear chromosome segregation
E4188_RS13685	COG3115	cell septum assembly
E4188_RS13690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4188_RS13700	COG1328	CTP reductase activity
E4188_RS13705	COG0602	queuosine metabolic process
E4188_RS13730	COG1566	PFAM secretion protein HlyD family protein
E4188_RS13745	COG0281	malic enzyme
E4188_RS13750	COG3290	protein histidine kinase activity
E4188_RS13760	COG0697	spore germination
E4188_RS13770	COG1012	belongs to the aldehyde dehydrogenase family
E4188_RS13775	COG3284	Transcriptional regulator
E4188_RS13780	COG3706	GGDEF domain
E4188_RS13785	COG3039	Transposase
E4188_RS13790	COG0346	lactoylglutathione lyase activity
E4188_RS13795	COG0745	RESPONSE REGULATOR receiver
E4188_RS13800	COG5002	protein histidine kinase activity
E4188_RS13810	COG4783	chaperone-mediated protein folding
E4188_RS13820	COG1940	carbohydrate kinase activity
E4188_RS13825	COG3142	Participates in the control of copper homeostasis
E4188_RS13830	COG0545	Peptidyl-prolyl cis-trans isomerase
E4188_RS13835	COG1131	(ABC) transporter
E4188_RS13850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_RS13855	COG4597	amino acid ABC transporter
E4188_RS13860	COG0765	amino acid transport
E4188_RS13865	COG1126	abc transporter atp-binding protein
E4188_RS13875	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E4188_RS13880	COG0678	peroxiredoxin activity
E4188_RS13890	COG0019	diaminopimelate decarboxylase activity
E4188_RS13895	COG1115	amino acid carrier protein
E4188_RS13900	COG0095	Lipoate-protein ligase
E4188_RS13905	COG2233	PERMEase
E4188_RS13920	COG0534	Mate efflux family protein
E4188_RS13930	COG0281	malic enzyme
E4188_RS13960	COG0733	neurotransmitter:sodium symporter activity
E4188_RS13965	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4188_RS13970	COG3706	GGDEF domain
E4188_RS13985	COG1032	radical SAM domain protein
E4188_RS13995	COG5433	transposase activity
E4188_RS14025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_RS14040	COG0673	inositol 2-dehydrogenase activity
E4188_RS14045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4188_RS14050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4188_RS14055	COG0739	heme binding
E4188_RS14055	COG1196	nuclear chromosome segregation
E4188_RS14055	COG0741	lytic transglycosylase activity
E4188_RS14080	COG0788	formyltetrahydrofolate deformylase activity
E4188_RS14085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4188_RS14095	COG3118	belongs to the thioredoxin family
E4188_RS14105	COG0791	NLP P60 protein
E4188_RS14110	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E4188_RS14125	COG1376	ErfK ybiS ycfS ynhG family protein
E4188_RS14125	COG1388	LysM domain
E4188_RS14145	COG3901	Regulator of nitric oxide reductase transcription
E4188_RS14145	COG0348	domain, Protein
E4188_RS14150	COG4263	nitrous-oxide reductase activity
E4188_RS14165	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4188_RS14175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E4188_RS14250	COG2205	protein histidine kinase activity
E4188_RS14250	COG0784	Response regulator, receiver
E4188_RS14250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_RS14250	COG2198	Histidine kinase
E4188_RS14255	COG4584	PFAM Integrase catalytic
E4188_RS14260	COG1484	DNA-dependent DNA replication
E4188_RS14270	COG3384	dioxygenase
E4188_RS14280	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4188_RS14290	COG0531	amino acid
E4188_RS14295	COG0531	amino acid
E4188_RS14315	COG1396	sequence-specific DNA binding
E4188_RS14315	COG1917	Cupin 2, conserved barrel domain protein
E4188_RS14320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4188_RS14340	COG2974	May be involved in recombination
E4188_RS14345	COG0456	acetyltransferase
E4188_RS14350	COG0420	3'-5' exonuclease activity
E4188_RS14360	COG3038	cytochrome b561
E4188_RS14365	COG2190	(PTS) system
E4188_RS14375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_RS14380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4188_RS14385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4188_RS14400	COG1720	tRNA m6t6A37 methyltransferase activity
E4188_RS14420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4188_RS14425	COG4988	ABC transporter
E4188_RS14440	COG0745	RESPONSE REGULATOR receiver
E4188_RS14450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4188_RS14485	COG3153	acetyltransferase
E4188_RS14505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4188_RS14510	COG2867	negative regulation of translational initiation
E4188_RS14535	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4188_RS14550	COG0564	pseudouridine synthase activity
E4188_RS14580	COG1280	lysine exporter protein (LysE YggA)
E4188_RS14595	COG3263	regulation of cellular component size
E4188_RS14605	COG1876	peptidase activity
E4188_RS14610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4188_RS14615	COG1393	Belongs to the ArsC family
E4188_RS14630	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E4188_RS14640	COG1902	pentaerythritol trinitrate reductase activity
E4188_RS14650	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_RS14650	COG0604	alcohol dehydrogenase
E4188_RS14650	COG3321	synthase
E4188_RS14655	COG0017	Asparaginyl-tRNA synthetase
E4188_RS14675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E4188_RS14680	COG0156	8-amino-7-oxononanoate synthase activity
E4188_RS14685	COG2226	methyltransferase
E4188_RS14685	COG1073	alpha beta
E4188_RS14690	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4188_RS14695	COG0501	Belongs to the peptidase M48B family
E4188_RS14700	COG0633	Ferredoxin
E4188_RS14700	COG3217	Mosc domain protein beta barrel domain protein
E4188_RS14700	COG0633	Ferredoxin
E4188_RS14700	COG3217	Mosc domain protein beta barrel domain protein
E4188_RS14710	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4188_RS14710	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4188_RS14710	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4188_RS14710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4188_RS14720	COG2841	Protein conserved in bacteria
E4188_RS14730	COG0534	Mate efflux family protein
E4188_RS14765	COG1309	transcriptional regulator
E4188_RS14780	COG0791	NLP P60 protein
E4188_RS14785	COG0583	DNA-binding transcription factor activity
E4188_RS14805	COG0500	methyltransferase
E4188_RS14810	COG4106	trans-aconitate 2-methyltransferase activity
E4188_RS14815	COG1801	Protein of unknown function DUF72
E4188_RS14820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4188_RS14825	COG0217	transcriptional regulatory protein
E4188_RS14835	COG1846	Transcriptional regulator
E4188_RS14835	COG1940	carbohydrate kinase activity
E4188_RS14840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4188_RS14845	COG0363	glucosamine-6-phosphate deaminase activity
E4188_RS14850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4188_RS14850	COG1263	PTS System
E4188_RS14850	COG2190	(PTS) system
E4188_RS14860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4188_RS14865	COG0735	belongs to the Fur family
E4188_RS14875	COG0716	FMN binding
E4188_RS14890	COG0596	Alpha beta hydrolase
E4188_RS14895	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E4188_RS14900	COG0033	Phosphoglucomutase
E4188_RS14910	COG1846	Transcriptional regulator
E4188_RS14915	COG2951	lytic endotransglycosylase activity
E4188_RS14920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4188_RS14925	COG4136	ATPase activity
E4188_RS14935	COG4134	Bacterial extracellular solute-binding protein
E4188_RS14945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4188_RS14955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4188_RS14965	COG0729	surface antigen
E4188_RS14990	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4188_RS15000	COG0741	lytic transglycosylase activity
E4188_RS15015	COG1607	acyl-coa hydrolase
E4188_RS15030	COG1388	LysM domain
E4188_RS15030	COG0741	lytic transglycosylase activity
E4188_RS15035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4188_RS15040	COG2226	methyltransferase
E4188_RS15045	COG0328	RNA-DNA hybrid ribonuclease activity
E4188_RS15050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4188_RS15060	COG3437	response regulator, receiver
E4188_RS15060	COG0784	Response regulator, receiver
E4188_RS15065	COG1960	acyl-CoA dehydrogenase activity
E4188_RS15070	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4188_RS15075	COG0121	glutamine amidotransferase
E4188_RS15085	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4188_RS15110	COG2197	response regulator
E4188_RS15115	COG3850	Histidine kinase
E4188_RS15120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4188_RS15125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4188_RS15135	COG0243	molybdopterin cofactor binding
E4188_RS15140	COG0437	4 iron, 4 sulfur cluster binding
E4188_RS15145	COG0348	domain, Protein
E4188_RS15155	COG3005	denitrification pathway
E4188_RS15160	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4188_RS15165	COG0315	cyclic pyranopterin monophosphate synthase activity
E4188_RS15170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4188_RS15175	COG0314	molybdopterin synthase activity
E4188_RS15190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4188_RS15195	COG0596	Alpha beta hydrolase
E4188_RS15200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4188_RS15210	COG0302	gtp cyclohydrolase
E4188_RS15215	COG0840	transmembrane signaling receptor activity
E4188_RS15220	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4188_RS15230	COG0583	DNA-binding transcription factor activity
E4188_RS15235	COG2353	YceI-like domain
E4188_RS15245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4188_RS15260	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4188_RS15270	COG1166	arginine decarboxylase activity
E4188_RS15325	COG5433	transposase activity
E4188_RS15340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4188_RS15345	COG1187	pseudouridine synthase activity
E4188_RS15350	COG2807	transmembrane transport
E4188_RS15390	COG2979	Protein of unknown function (DUF533)
E4188_RS15405	COG1595	DNA-templated transcription, initiation
E4188_RS15420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4188_RS15430	COG1294	oxidase, subunit
E4188_RS15440	COG2814	Major facilitator Superfamily
E4188_RS15445	COG0656	L-ascorbic acid biosynthetic process
E4188_RS15465	COG0583	DNA-binding transcription factor activity
E4188_RS15470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4188_RS15475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4188_RS15480	COG2271	Major facilitator Superfamily
E4188_RS15485	COG1349	DNA-binding transcription factor activity
E4188_RS15495	COG0584	glycerophosphoryl diester phosphodiesterase
E4188_RS15500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4188_RS15505	COG0287	Prephenate dehydrogenase
E4188_RS15505	COG1605	Chorismate mutase
E4188_RS15515	COG3085	chromosome segregation
E4188_RS15520	COG4574	serine-type endopeptidase inhibitor activity
E4188_RS15540	COG1770	oligopeptidase
E4188_RS15545	COG4206	TonB-dependent receptor
E4188_RS15550	COG3083	sulfuric ester hydrolase activity
E4188_RS15555	COG3082	Protein of unknown function (DUF1414)
E4188_RS15560	COG3081	Nucleoid-associated protein
E4188_RS15565	COG2182	Extracellular solute-binding protein
E4188_RS15570	COG1175	transmembrane transport
E4188_RS15575	COG3833	ABC-type maltose transport systems, permease component
E4188_RS15580	COG3842	ATPase activity
E4188_RS15610	COG4783	chaperone-mediated protein folding
E4188_RS15620	COG1393	Belongs to the ArsC family
E4188_RS15630	COG1228	amidohydrolase
E4188_RS15645	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4188_RS15650	COG2431	L-lysine efflux transmembrane transporter activity
E4188_RS15660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_RS15680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4188_RS15690	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4188_RS15710	COG2271	Major facilitator Superfamily
E4188_RS15750	COG2373	Large extracellular alpha-helical protein
E4188_RS15755	COG4953	penicillin-binding protein 1C
E4188_RS15770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4188_RS15770	COG0301	tRNA thio-modification
E4188_RS15790	COG1334	flagellar protein FlaG
E4188_RS15825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4188_RS15835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4188_RS15850	COG0346	lactoylglutathione lyase activity
E4188_RS15855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4188_RS15860	COG4660	Part of a membrane complex involved in electron transport
E4188_RS15865	COG4659	FMN binding
E4188_RS15870	COG4658	electron transport chain
E4188_RS15875	COG4656	Part of a membrane complex involved in electron transport
E4188_RS15880	COG2878	Part of a membrane complex involved in electron transport
E4188_RS15885	COG4657	Part of a membrane complex involved in electron transport
E4188_RS15890	COG0697	spore germination
E4188_RS15910	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4188_RS15915	COG1288	antiporter activity
E4188_RS15920	COG0436	Aminotransferase
E4188_RS15930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4188_RS15935	COG2027	D-alanyl-D-alanine carboxypeptidase
E4188_RS15940	COG1061	Type III restriction enzyme res subunit
E4188_RS15945	COG1566	PFAM secretion protein HlyD family protein
E4188_RS15955	COG3264	Mechanosensitive ion channel
E4188_RS15955	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4188_RS15960	COG1966	Carbon starvation protein
E4188_RS15965	COG3279	Response regulator of the LytR AlgR family
E4188_RS15970	COG3275	phosphorelay sensor kinase activity
E4188_RS15980	COG1012	belongs to the aldehyde dehydrogenase family
E4188_RS15980	COG1454	alcohol dehydrogenase
E4188_RS15985	COG2095	MarC family integral membrane protein
E4188_RS15995	COG0601	transmembrane transport
E4188_RS16000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4188_RS16005	COG0444	Belongs to the ABC transporter superfamily
E4188_RS16015	COG0861	Integral membrane protein TerC family
E4188_RS16020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4188_RS16030	COG1301	dicarboxylic acid transport
E4188_RS16045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4188_RS16060	COG0537	adenosine 5'-monophosphoramidase activity
E4188_RS16095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4188_RS16100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4188_RS16110	COG2354	Protein conserved in bacteria
E4188_RS16125	COG3150	esterase
E4188_RS16130	COG1252	NADH dehydrogenase
E4188_RS16145	COG0393	Putative heavy-metal-binding
E4188_RS16150	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4188_RS16155	COG1368	sulfuric ester hydrolase activity
E4188_RS16165	COG0527	aspartate kinase activity
E4188_RS16175	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4188_RS16175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4188_RS16180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4188_RS16195	COG2315	Protein conserved in bacteria
E4188_RS16205	COG0583	DNA-binding transcription factor activity
E4188_RS16210	COG1620	l-lactate permease
E4188_RS16215	COG0247	lactate metabolic process
E4188_RS16220	COG1139	Iron-sulfur cluster binding protein
E4188_RS16260	COG3039	Transposase
E4188_RS16280	COG1136	(ABC) transporter
E4188_RS16300	COG2814	Major facilitator Superfamily
E4188_RS16320	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E4188_RS16320	COG0493	'glutamate synthase
E4188_RS16325	COG0672	)-iron permease
E4188_RS16360	COG2308	Evidence 4 Homologs of previously reported genes of
E4188_RS16380	COG0659	secondary active sulfate transmembrane transporter activity
E4188_RS16395	COG5433	transposase activity
E4188_RS16405	COG3039	Transposase
E4188_RS16420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4188_RS16425	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_RS16430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4188_RS16435	COG1902	pentaerythritol trinitrate reductase activity
E4188_RS16440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4188_RS16450	COG4974	Belongs to the 'phage' integrase family
E4188_RS16455	COG3039	Transposase
E4188_RS16465	COG3039	Transposase
E4188_RS16470	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E4188_RS16475	COG0437	4 iron, 4 sulfur cluster binding
E4188_RS16480	COG5557	Pfam Polysulphide reductase, NrfD
E4188_RS16485	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E4188_RS16490	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E4188_RS16495	COG1773	rubredoxin
E4188_RS16505	COG0601	transmembrane transport
E4188_RS16510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4188_RS16515	COG0444	Belongs to the ABC transporter superfamily
E4188_RS16520	COG1124	(ABC) transporter
E4188_RS16525	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4188_RS16530	COG0375	protein maturation
E4188_RS16535	COG0309	Hydrogenase expression formation protein (HypE)
E4188_RS16545	COG0298	carbon dioxide binding
E4188_RS16550	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E4188_RS16555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4188_RS16560	COG0326	Molecular chaperone. Has ATPase activity
E4188_RS16565	COG0563	adenylate kinase activity
E4188_RS16570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E4188_RS16580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4188_RS16585	COG0840	transmembrane signaling receptor activity
E4188_RS16600	COG3300	MHYT domain
E4188_RS16600	COG5001	Diguanylate cyclase
E4188_RS16605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4188_RS16625	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4188_RS16630	COG3433	isochorismatase activity
E4188_RS16630	COG1535	isochorismatase
E4188_RS16635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4188_RS16640	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_RS16650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4188_RS16655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4188_RS16665	COG1120	ATPase activity
E4188_RS16670	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4188_RS16675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4188_RS16680	COG4771	TonB-dependent receptor
E4188_RS16705	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4188_RS16705	COG0644	oxidoreductase
E4188_RS16725	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4188_RS16730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4188_RS16735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4188_RS16740	COG0861	Integral membrane protein TerC family
E4188_RS16755	COG1022	Amp-dependent synthetase and ligase
E4188_RS16760	COG0295	cytidine deaminase activity
E4188_RS16765	COG1346	cytolysis
E4188_RS16770	COG1380	Effector of murein hydrolase LrgA
E4188_RS16775	COG3345	alpha-galactosidase
E4188_RS16785	COG2925	Exonuclease
E4188_RS16790	COG0582	viral genome integration into host DNA
E4188_RS16855	COG1846	Transcriptional regulator
E4188_RS16870	COG3646	Phage regulatory protein
E4188_RS16885	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E4188_RS16930	COG4626	Terminase
E4188_RS16930	COG1802	Transcriptional regulator
E4188_RS17035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4188_RS17040	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E4188_RS17040	COG0392	lysyltransferase activity
E4188_RS17055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4188_RS17060	COG0436	Aminotransferase
E4188_RS17065	COG0583	DNA-binding transcription factor activity
E4188_RS17070	COG2160	L-arabinose isomerase activity
E4188_RS17080	COG1069	ribulokinase activity
E4188_RS17085	COG1879	ABC-type sugar transport system periplasmic component
E4188_RS17095	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4188_RS17105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4188_RS17110	COG0254	rRNA binding
E4188_RS17120	COG2731	YhcH YjgK YiaL family protein
E4188_RS17125	COG0800	Aldolase
E4188_RS17130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4188_RS17145	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_RS17165	COG1451	nucleotide metabolic process
E4188_RS17180	COG3069	C4-dicarboxylate transmembrane transporter activity
E4188_RS17190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4188_RS17190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4188_RS17195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4188_RS17220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4188_RS17225	COG1053	succinate dehydrogenase
E4188_RS17235	COG0567	Dehydrogenase, E1 component
E4188_RS17240	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4188_RS17245	COG0045	succinate-CoA ligase (ADP-forming) activity
E4188_RS17250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4188_RS17265	COG2983	Belongs to the UPF0260 family
E4188_RS17270	COG1882	Formate acetyltransferase
E4188_RS17275	COG2116	formate transmembrane transporter activity
E4188_RS17280	COG1944	ATP diphosphatase activity
E4188_RS17300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4188_RS17305	COG1278	Cold shock
E4188_RS17310	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4188_RS17315	COG0542	response to heat
E4188_RS17320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4188_RS17325	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E4188_RS17330	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4188_RS17335	COG3134	Outer membrane lipoprotein
E4188_RS17340	COG3706	GGDEF domain
E4188_RS17345	COG0492	ferredoxin-NADP+ reductase activity
E4188_RS17350	COG0686	Belongs to the AlaDH PNT family
E4188_RS17360	COG1674	ftsk spoiiie
E4188_RS17360	COG0531	amino acid
E4188_RS17365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4188_RS17370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4188_RS17375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4188_RS17380	COG1286	toxin biosynthetic process
E4188_RS17385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4188_RS17390	COG2723	6-phospho-beta-galactosidase activity
E4188_RS17395	COG1263	PTS System
E4188_RS17395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4188_RS17400	COG1609	Transcriptional regulator
E4188_RS17410	COG4172	Belongs to the ABC transporter superfamily
E4188_RS17420	COG4171	peptide transport system, permease
E4188_RS17425	COG4168	peptide transport system, permease
E4188_RS17435	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4188_RS17440	COG1842	Phage shock protein A
E4188_RS17455	COG3106	COG3106 Predicted ATPase
E4188_RS17460	COG3768	UPF0283 membrane protein
E4188_RS17470	COG2154	pterin-4-alpha-carbinolamine dehydratase
E4188_RS17485	COG2199	diguanylate cyclase activity
E4188_RS17490	COG2885	chlorophyll binding
E4188_RS17500	COG1570	exodeoxyribonuclease VII activity
E4188_RS17510	COG0366	Alpha amylase catalytic
E4188_RS17510	COG1874	Beta-galactosidase
E4188_RS17520	COG0516	GMP reductase activity
E4188_RS17520	COG0517	IMP dehydrogenase activity
E4188_RS17525	COG0519	Catalyzes the synthesis of GMP from XMP
E4188_RS17525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4188_RS17555	COG2062	phosphohistidine phosphatase, SixA
E4188_RS17565	COG0697	spore germination
E4188_RS17570	COG4166	transmembrane transport
E4188_RS17575	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E4188_RS17580	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4188_RS17590	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4188_RS17595	COG1136	(ABC) transporter
E4188_RS17600	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4188_RS17615	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4188_RS17620	COG0740	serine-type endopeptidase activity
E4188_RS17625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4188_RS17630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4188_RS17635	COG0776	regulation of translation
E4188_RS17640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4188_RS17645	COG0488	(ABC) transporter
E4188_RS17650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4188_RS17655	COG3162	membrane
E4188_RS17660	COG2176	DNA-directed DNA polymerase activity
E4188_RS17670	COG1024	Enoyl-CoA hydratase
E4188_RS17675	COG1115	amino acid carrier protein
E4188_RS17690	COG1584	GPR1 FUN34 yaaH family protein
E4188_RS17715	COG1024	Enoyl-CoA hydratase
E4188_RS17725	COG1960	acyl-CoA dehydrogenase activity
E4188_RS17735	COG1960	acyl-CoA dehydrogenase activity
E4188_RS17740	COG1024	Enoyl-CoA hydratase
E4188_RS17745	COG1024	Enoyl-CoA hydratase
E4188_RS17755	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_RS17765	COG0730	response to heat
E4188_RS17785	COG3039	Transposase
E4188_RS17800	COG3039	Transposase
E4188_RS17815	COG5433	transposase activity
E4188_RS17835	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4188_RS17840	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4188_RS17845	COG1129	ABC transporter
E4188_RS17850	COG1879	ABC-type sugar transport system periplasmic component
E4188_RS17855	COG0583	DNA-binding transcription factor activity
E4188_RS17870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4188_RS17875	COG0243	molybdopterin cofactor binding
E4188_RS17885	COG3706	GGDEF domain
E4188_RS17890	COG0583	DNA-binding transcription factor activity
E4188_RS17895	COG2723	6-phospho-beta-galactosidase activity
E4188_RS17900	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_RS17905	COG0583	DNA-binding transcription factor activity
E4188_RS17925	COG5433	transposase activity
E4188_RS17930	COG3706	GGDEF domain
E4188_RS17960	COG1742	UPF0060 membrane protein
E4188_RS17975	COG0513	Belongs to the DEAD box helicase family
E4188_RS17980	COG0386	Belongs to the glutathione peroxidase family
E4188_RS17990	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4188_RS18005	COG0730	response to heat
E4188_RS18010	COG0583	DNA-binding transcription factor activity
E4188_RS18025	COG3593	DNA synthesis involved in DNA repair
E4188_RS18075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4188_RS18080	COG1011	Hydrolase
E4188_RS18085	COG1473	amidohydrolase
E4188_RS18090	COG0205	6-phosphofructokinase activity
E4188_RS18100	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E4188_RS18105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4188_RS18115	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E4188_RS18120	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E4188_RS18185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_RS18190	COG2824	Alkylphosphonate utilization operon protein PhnA
E4188_RS18220	COG0406	alpha-ribazole phosphatase activity
E4188_RS18230	COG2840	Smr protein MutS2
E4188_RS18235	COG2890	protein-(glutamine-N5) methyltransferase activity
E4188_RS18240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4188_RS18250	COG0513	Belongs to the DEAD box helicase family
E4188_RS18255	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E4188_RS18260	COG0814	amino acid
E4188_RS18265	COG1609	Transcriptional regulator
E4188_RS18270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_RS18270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4188_RS18275	COG1105	Belongs to the carbohydrate kinase PfkB family
E4188_RS18280	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4188_RS18280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4188_RS18280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4188_RS18285	COG3313	Fe-S protein
E4188_RS18290	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4188_RS18295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4188_RS18305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4188_RS18315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4188_RS18345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4188_RS18350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4188_RS18355	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4188_RS18360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4188_RS18380	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_RS18385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4188_RS18390	COG0072	phenylalanine-tRNA ligase activity
E4188_RS18390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4188_RS18395	COG0776	regulation of translation
E4188_RS18400	COG2205	protein histidine kinase activity
E4188_RS18400	COG0784	Response regulator, receiver
E4188_RS18425	COG5001	Diguanylate cyclase
E4188_RS18425	COG3300	MHYT domain
E4188_RS18430	COG1609	Transcriptional regulator
E4188_RS18435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4188_RS18440	COG1879	ABC-type sugar transport system periplasmic component
E4188_RS18445	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4188_RS18450	COG1129	ABC transporter
E4188_RS18455	COG1869	D-ribose catabolic process
E4188_RS18475	COG0037	tRNA processing
E4188_RS18480	COG0589	response to stress
E4188_RS18485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4188_RS18510	COG2010	Cytochrome c
E4188_RS18525	COG3278	Belongs to the heme-copper respiratory oxidase family
E4188_RS18535	COG1956	GAF domain-containing protein
E4188_RS18540	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E4188_RS18550	COG0308	aminopeptidase N
E4188_RS18560	COG2902	Dehydrogenase
E4188_RS18565	COG0167	dihydroorotate dehydrogenase activity
E4188_RS18575	COG0116	Belongs to the methyltransferase superfamily
E4188_RS18575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4188_RS18585	COG0488	(ABC) transporter
E4188_RS18600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4188_RS18605	COG1067	ATP-dependent peptidase activity
E4188_RS18670	COG3141	response to X-ray
E4188_RS18680	COG2995	paraquat-inducible protein a
E4188_RS18685	COG3008	intermembrane lipid transfer
E4188_RS18690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4188_RS18690	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E4188_RS18705	COG0084	hydrolase, TatD family'
E4188_RS18710	COG0470	DNA polymerase III
E4188_RS18715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4188_RS18720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4188_RS18725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4188_RS18735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4188_RS18740	COG1028	Short-chain dehydrogenase reductase Sdr
E4188_RS18750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4188_RS18755	COG0416	fatty acid biosynthetic process
E4188_RS18760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4188_RS18765	COG1399	metal-binding, possibly nucleic acid-binding protein
E4188_RS18775	COG0424	maF-like protein
E4188_RS18780	COG0546	phosphoglycolate phosphatase activity
E4188_RS18790	COG1530	ribonuclease E activity
E4188_RS18795	COG0306	phosphate transporter
E4188_RS18800	COG0717	Belongs to the dCTP deaminase family
E4188_RS18805	COG0572	uridine kinase
E4188_RS18810	COG0489	protein tyrosine kinase activity
E4188_RS18815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4188_RS18815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4188_RS18825	COG1254	Belongs to the acylphosphatase family
E4188_RS18830	COG0840	transmembrane signaling receptor activity
E4188_RS18835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4188_RS18845	COG0709	Synthesizes selenophosphate from selenide and ATP
E4188_RS18850	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4188_RS18855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4188_RS18860	COG3437	response regulator, receiver
E4188_RS18870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4188_RS18880	COG1643	Atp-dependent helicase
E4188_RS18885	COG0617	tRNA 3'-terminal CCA addition
E4188_RS18885	COG0517	IMP dehydrogenase activity
E4188_RS18885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4188_RS18890	COG2197	response regulator
E4188_RS18910	COG1335	isochorismatase
E4188_RS18915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4188_RS18925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4188_RS18930	COG2832	Protein of unknown function (DUF454)
E4188_RS18935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4188_RS18945	COG0697	spore germination
E4188_RS18955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E4188_RS18960	COG0318	PFAM AMP-dependent synthetase and ligase
E4188_RS18965	COG0596	Alpha beta hydrolase
E4188_RS18975	COG1214	PFAM Peptidase M22, glycoprotease
E4188_RS18980	COG1199	ATP-dependent helicase activity
E4188_RS18990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4188_RS18995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4188_RS19000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4188_RS19005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4188_RS19005	COG0131	Imidazoleglycerol-phosphate dehydratase
E4188_RS19010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4188_RS19015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E4188_RS19020	COG3437	response regulator, receiver
E4188_RS19030	COG2205	protein histidine kinase activity
E4188_RS19030	COG0784	Response regulator, receiver
E4188_RS19030	COG2198	Histidine kinase
E4188_RS19035	COG0107	imidazoleglycerol-phosphate synthase activity
E4188_RS19040	COG0140	phosphoribosyl-ATP diphosphatase activity
E4188_RS19040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4188_RS19050	COG2378	regulation of single-species biofilm formation
E4188_RS19055	COG0318	PFAM AMP-dependent synthetase and ligase
E4188_RS19060	COG3134	Outer membrane lipoprotein
E4188_RS19075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4188_RS19100	COG4681	YaeQ
E4188_RS19110	COG1024	Enoyl-CoA hydratase
E4188_RS19110	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4188_RS19115	COG0183	Belongs to the thiolase family
E4188_RS19120	COG0714	Associated with various cellular activities
E4188_RS19140	COG2304	oxidoreductase activity
E4188_RS19150	COG1595	DNA-templated transcription, initiation
E4188_RS19160	COG2067	long-chain fatty acid transport protein
E4188_RS19165	COG2067	long-chain fatty acid transport protein
E4188_RS19170	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E4188_RS19175	COG2067	long-chain fatty acid transport protein
E4188_RS19190	COG1301	dicarboxylic acid transport
E4188_RS19195	COG3123	guanosine phosphorylase activity
E4188_RS19200	COG1760	l-serine dehydratase
E4188_RS19205	COG1760	l-serine dehydratase
E4188_RS19210	COG2951	lytic endotransglycosylase activity
E4188_RS19215	COG3100	YcgL domain-containing protein
E4188_RS19220	COG0850	regulation of cytokinetic process
E4188_RS19225	COG2894	cell division
E4188_RS19230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E4188_RS19235	COG3099	Belongs to the UPF0263 family
E4188_RS19240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4188_RS19280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4188_RS19285	COG0697	spore germination
E4188_RS19290	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E4188_RS19295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4188_RS19305	COG0307	riboflavin synthase, alpha
E4188_RS19345	COG0417	DNA replication proofreading
E4188_RS19365	COG1560	Kdo2-lipid A biosynthetic process
E4188_RS19370	COG1560	Kdo2-lipid A biosynthetic process
E4188_RS19380	COG0583	DNA-binding transcription factor activity
E4188_RS19385	COG0673	inositol 2-dehydrogenase activity
E4188_RS19390	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E4188_RS19395	COG2329	Antibiotic biosynthesis monooxygenase
E4188_RS19400	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E4188_RS19430	COG2501	S4 domain
E4188_RS19445	COG1132	(ABC) transporter
E4188_RS19450	COG1132	(ABC) transporter
E4188_RS19460	COG3118	belongs to the thioredoxin family
E4188_RS19465	COG0471	metal ion transport
E4188_RS19475	COG0058	SHG alpha-glucan phosphorylase activity
E4188_RS19505	COG0814	amino acid
E4188_RS19510	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4188_RS19515	COG0514	ATP-dependent DNA helicase (RecQ)
E4188_RS19520	COG2766	serine protein kinase
E4188_RS19525	COG2718	Belongs to the UPF0229 family
E4188_RS19530	COG2719	SpoVR family
E4188_RS19540	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4188_RS19545	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E4188_RS19555	COG0586	Pfam SNARE associated Golgi protein
E4188_RS19565	COG0556	nucleotide-excision repair
E4188_RS19575	COG0569	domain protein
E4188_RS19575	COG2985	domain, Protein
E4188_RS19580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4188_RS19600	COG4565	transcriptional regulatory protein
E4188_RS19605	COG3290	protein histidine kinase activity
E4188_RS19610	COG1940	carbohydrate kinase activity
E4188_RS19610	COG1846	Transcriptional regulator
E4188_RS19620	COG3012	SEC-C Motif Domain Protein
E4188_RS19625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4188_RS19630	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E4188_RS19635	COG0247	lactate metabolic process
E4188_RS19645	COG5433	transposase activity
E4188_RS19660	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E4188_RS19665	COG0437	4 iron, 4 sulfur cluster binding
E4188_RS19670	COG3301	Polysulphide reductase, NrfD
E4188_RS19675	COG1138	Cytochrome C-type biogenesis protein
E4188_RS19680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4188_RS19685	COG4235	cytochrome complex assembly
E4188_RS19685	COG3088	subunit of a heme lyase
E4188_RS19705	COG3046	protein related to deoxyribodipyrimidine photolyase
E4188_RS19710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4188_RS19725	COG0517	IMP dehydrogenase activity
E4188_RS19735	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4188_RS19740	COG0583	DNA-binding transcription factor activity
E4188_RS19750	COG4774	siderophore transport
E4188_RS19755	COG2207	Transcriptional regulator
E4188_RS19755	COG3708	Transcriptional regulator
E4188_RS19765	COG0583	DNA-binding transcription factor activity
E4188_RS19770	COG2910	NAD(P)H-binding
E4188_RS19785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4188_RS19810	COG3039	Transposase
E4188_RS19920	COG3328	transposase activity
E4188_RS19935	COG3550	peptidyl-serine autophosphorylation
E4188_RS19945	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E4188_RS19970	COG1435	thymidine kinase activity
E4188_RS19975	COG1757	Na H antiporter
E4188_RS19980	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4188_RS19985	COG2096	Adenosyltransferase
E4188_RS19990	COG3530	Putative quorum-sensing-regulated virulence factor
E4188_RS19995	COG0602	queuosine metabolic process
E4188_RS20000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4188_RS20020	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4188_RS20030	COG0776	regulation of translation
E4188_RS20035	COG0539	negative regulation of cytoplasmic translation
E4188_RS20040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4188_RS20045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4188_RS20055	COG2814	Major facilitator Superfamily
E4188_RS20075	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4188_RS20080	COG3300	MHYT domain
E4188_RS20080	COG5001	Diguanylate cyclase
E4188_RS20090	COG0583	DNA-binding transcription factor activity
E4188_RS20095	COG3437	response regulator, receiver
E4188_RS20120	COG4989	oxidoreductase activity
E4188_RS20125	COG0724	RNA recognition motif
E4188_RS20145	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4188_RS20165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4188_RS20170	COG1360	Flagellar Motor Protein
E4188_RS20175	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4188_RS20180	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4188_RS20185	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4188_RS20185	COG0649	NAD binding
E4188_RS20200	COG1034	ATP synthesis coupled electron transport
E4188_RS20205	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E4188_RS20210	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4188_RS20215	COG0839	Belongs to the complex I subunit 6 family
E4188_RS20220	COG0713	ATP synthesis coupled electron transport
E4188_RS20230	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4188_RS20235	COG1007	ATP synthesis coupled electron transport
E4188_RS20240	COG0047	phosphoribosylformylglycinamidine synthase activity
E4188_RS20240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4188_RS20245	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4188_RS20255	COG1160	GTP binding
E4188_RS20260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4188_RS20265	COG2976	Protein conserved in bacteria
E4188_RS20270	COG0124	histidyl-tRNA synthetase
E4188_RS20290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4188_RS20295	COG0105	UTP biosynthetic process
E4188_RS20300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4188_RS20310	COG0633	Ferredoxin
E4188_RS20315	COG0443	Heat shock 70 kDa protein
E4188_RS20320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E4188_RS20330	COG0822	iron-sulfur transferase activity
E4188_RS20335	COG1104	cysteine desulfurase activity
E4188_RS20355	COG3154	lipid carrier protein
E4188_RS20360	COG0826	peptidase U32
E4188_RS20365	COG0826	peptidase U32
E4188_RS20380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4188_RS20385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4188_RS20390	COG1862	Preprotein translocase
E4188_RS20395	COG0343	queuine tRNA-ribosyltransferase activity
E4188_RS20400	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4188_RS20405	COG0517	IMP dehydrogenase activity
E4188_RS20415	COG3634	alkyl hydroperoxide reductase activity
E4188_RS20445	COG3039	Transposase
E4188_RS20455	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4188_RS20455	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4188_RS20460	COG0509	glycine decarboxylation via glycine cleavage system
E4188_RS20465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4188_RS20470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4188_RS20475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4188_RS20485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_RS20515	COG2814	Major facilitator Superfamily
E4188_RS20520	COG0577	efflux transmembrane transporter activity
E4188_RS20520	COG1136	(ABC) transporter
E4188_RS20525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4188_RS20530	COG0601	transmembrane transport
E4188_RS20540	COG0625	glutathione transferase activity
E4188_RS20555	COG0483	inositol monophosphate 1-phosphatase activity
E4188_RS20570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4188_RS20575	COG2056	Na+-H+ antiporter family
E4188_RS20580	COG2814	Major facilitator Superfamily
E4188_RS20585	COG0583	DNA-binding transcription factor activity
E4188_RS20590	COG5001	Diguanylate cyclase
E4188_RS20600	COG0513	Belongs to the DEAD box helicase family
E4188_RS20605	COG2050	protein possibly involved in aromatic compounds catabolism
E4188_RS20615	COG0277	FAD linked oxidase domain protein
E4188_RS20615	COG0247	lactate metabolic process
E4188_RS20625	COG1253	flavin adenine dinucleotide binding
E4188_RS20630	COG1902	pentaerythritol trinitrate reductase activity
E4188_RS20635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4188_RS20640	COG0647	UMP catabolic process
E4188_RS20650	COG0367	asparagine synthase
E4188_RS20660	COG0625	glutathione transferase activity
E4188_RS20670	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E4188_RS20685	COG0564	pseudouridine synthase activity
E4188_RS20690	COG3706	GGDEF domain
E4188_RS20700	COG0840	transmembrane signaling receptor activity
E4188_RS20705	COG0318	PFAM AMP-dependent synthetase and ligase
E4188_RS20725	COG4447	cellulose binding
E4188_RS20750	COG2855	membrane
E4188_RS20765	COG2814	Major facilitator Superfamily
E4188_RS20770	COG3246	L-lysine catabolic process to acetate
E4188_RS20775	COG2175	clavaminate synthase activity
E4188_RS20785	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E4188_RS20810	COG0670	Belongs to the BI1 family
E4188_RS20815	COG1289	transmembrane transporter activity
E4188_RS20820	COG2920	part of a sulfur-relay system
E4188_RS20825	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E4188_RS20830	COG0285	dihydrofolate synthase activity
E4188_RS20835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4188_RS20840	COG0101	tRNA pseudouridine synthase activity
E4188_RS20850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E4188_RS20855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4188_RS20860	COG0671	phosphoesterase, PA-phosphatase related
E4188_RS20865	COG1464	Belongs to the NlpA lipoprotein family
E4188_RS20885	COG1119	ATPase activity
E4188_RS20890	COG0574	Belongs to the PEP-utilizing enzyme family
E4188_RS20890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4188_RS20895	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4188_RS20905	COG1113	amino acid transport
E4188_RS20950	COG1242	4 iron, 4 sulfur cluster binding
E4188_RS20955	COG0067	glutamate synthase
E4188_RS20955	COG0069	glutamate synthase activity
E4188_RS20955	COG0070	glutamate synthase
E4188_RS20960	COG0493	'glutamate synthase
E4188_RS20970	COG1126	abc transporter atp-binding protein
E4188_RS20975	COG0765	amino acid transport
E4188_RS20980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_RS20995	COG4104	PAAR repeat-containing protein
E4188_RS21005	COG0513	Belongs to the DEAD box helicase family
E4188_RS21035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4188_RS21040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4188_RS21045	COG0505	Belongs to the CarA family
E4188_RS21050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E4188_RS21060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4188_RS21065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4188_RS21070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4188_RS21075	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4188_RS21080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4188_RS21085	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
E4188_RS21135	COG2119	membrane
E4188_RS21200	COG3039	Transposase
E4188_RS21210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4188_RS21220	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4188_RS21225	COG2261	transglycosylase associated protein
E4188_RS21230	COG0625	glutathione transferase activity
E4188_RS21315	COG0322	excinuclease ABC activity
E4188_RS21320	COG2197	response regulator
E4188_RS21325	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4188_RS21330	COG2835	tetraacyldisaccharide 4'-kinase activity
E4188_RS21335	COG1663	tetraacyldisaccharide 4'-kinase activity
E4188_RS21340	COG1132	(ABC) transporter
E4188_RS21345	COG0658	competence protein
E4188_RS21345	COG2333	competence protein COMEC
E4188_RS21360	COG0433	COG0433 Predicted ATPase
E4188_RS21365	COG1448	Aminotransferase
E4188_RS21395	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_RS21400	COG1199	ATP-dependent helicase activity
E4188_RS21410	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4188_RS21415	COG0477	Major facilitator Superfamily
E4188_RS21420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4188_RS21425	COG1785	Belongs to the alkaline phosphatase family
E4188_RS21445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4188_RS21450	COG2197	response regulator
E4188_RS21460	COG2271	Major facilitator Superfamily
E4188_RS21470	COG0675	Transposase, IS605 OrfB family
E4188_RS21485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4188_RS21490	COG0765	amino acid transport
E4188_RS21495	COG1126	abc transporter atp-binding protein
E4188_RS21505	COG0531	amino acid
E4188_RS21520	COG1253	flavin adenine dinucleotide binding
E4188_RS21535	COG0581	inorganic phosphate transmembrane transporter activity
E4188_RS21540	COG0573	inorganic phosphate transmembrane transporter activity
E4188_RS21560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4188_RS21585	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4188_RS21590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4188_RS21595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4188_RS21610	COG3852	Histidine kinase
E4188_RS21625	COG2716	regulation of RNA biosynthetic process
E4188_RS21630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4188_RS21655	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4188_RS21655	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4188_RS21660	COG1706	bacterial-type flagellum-dependent cell motility
E4188_RS21665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4188_RS21680	COG4786	Flagellar basal body rod
E4188_RS21695	COG1815	bacterial-type flagellum-dependent cell motility
E4188_RS21700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4188_RS21705	COG0835	chemotaxis
E4188_RS21705	COG0784	Response regulator, receiver
E4188_RS21710	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E4188_RS21725	COG0622	Phosphoesterase
E4188_RS21730	COG4166	transmembrane transport
E4188_RS21740	COG1187	pseudouridine synthase activity
E4188_RS21750	COG0675	Transposase, IS605 OrfB family
E4188_RS21770	COG0697	spore germination
E4188_RS21800	COG1278	Cold shock
E4188_RS21840	COG3132	Protein of unknown function, DUF480
E4188_RS21855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4188_RS21875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4188_RS21905	COG0297	glycogen (starch) synthase activity
E4188_RS21910	COG0438	transferase activity, transferring glycosyl groups
E4188_RS22260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4188_RS22290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4188_RS22490	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_RS22605	COG1988	membrane-bound metal-dependent
E4188_RS22680	COG0681	Belongs to the peptidase S26 family
E4188_RS22750	COG4676	Protein conserved in bacteria
E4188_RS22810	COG1192	Involved in chromosome partitioning
E4188_RS22835	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4188_RS22895	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4188_RS22905	COG4804	nuclease activity
E4188_RS22910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4188_RS22920	COG2200	EAL domain
E4188_RS22920	COG2771	luxR family
E4188_RS23035	COG4372	Transposase
E4188_RS23040	COG3436	PFAM IS66 Orf2 family protein
E4188_RS23075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4188_RS23120	COG4372	Transposase
E4188_RS23135	COG3173	Aminoglycoside phosphotransferase
E4188_RS23180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4188_RS23185	COG4644	lycopene metabolic process
E4188_RS23205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4188_RS23285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4188_RS23290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4188_RS23710	COG4372	Transposase
E4188_RS23730	COG0592	DNA-directed DNA polymerase activity