locus-tag	class	description
B224_RS00015	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B224_RS00025	COG1522	sequence-specific DNA binding
B224_RS00035	COG3135	benzoate transporter
B224_RS00040	COG1396	sequence-specific DNA binding
B224_RS00075	COG2926	Belongs to the UPF0265 family
B224_RS00085	COG3028	Belongs to the UPF0307 family
B224_RS00090	COG0312	modulator of DNA gyrase
B224_RS00095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B224_RS00100	COG5007	Belongs to the BolA IbaG family
B224_RS00110	COG2854	intermembrane phospholipid transfer
B224_RS00115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B224_RS00120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B224_RS00125	COG1127	ABC transporter
B224_RS00130	COG0517	IMP dehydrogenase activity
B224_RS00130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B224_RS00135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B224_RS00140	COG3117	lipopolysaccharide transmembrane transporter activity
B224_RS00145	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B224_RS00150	COG1137	ATPase activity
B224_RS00165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_RS00170	COG1660	Displays ATPase and GTPase activities
B224_RS00175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_RS00195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B224_RS00200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B224_RS00210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B224_RS00215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B224_RS00220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B224_RS00225	COG0723	plastoquinol--plastocyanin reductase activity
B224_RS00230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B224_RS00235	COG2857	Cytochrome c1
B224_RS00240	COG0625	glutathione transferase activity
B224_RS00245	COG2969	positive regulation of protein catabolic process
B224_RS00250	COG2823	Periplasmic or secreted lipoprotein
B224_RS00255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B224_RS00260	COG0792	nuclease activity
B224_RS00265	COG3107	peptidoglycan biosynthetic process
B224_RS00270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B224_RS00295	COG5433	transposase activity
B224_RS00320	COG3385	transposase activity
B224_RS00330	COG2001	Belongs to the MraZ family
B224_RS00335	COG0275	rRNA processing
B224_RS00340	COG3116	cell division
B224_RS00345	COG0768	penicillin binding
B224_RS00350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B224_RS00355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B224_RS00360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B224_RS00365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B224_RS00370	COG0772	Belongs to the SEDS family
B224_RS00375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B224_RS00380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B224_RS00385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B224_RS00390	COG0849	cell division
B224_RS00395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B224_RS00400	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B224_RS00410	COG0653	protein targeting
B224_RS00420	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B224_RS00425	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
B224_RS00435	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B224_RS00440	COG1459	type II secretion system
B224_RS00445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B224_RS00455	COG5433	transposase activity
B224_RS00480	COG2186	Transcriptional regulator
B224_RS00485	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B224_RS00490	COG0508	dehydrogenase complex catalyzes the overall conversion of
B224_RS00495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B224_RS00500	COG3706	GGDEF domain
B224_RS00515	COG0840	transmembrane signaling receptor activity
B224_RS00520	COG1752	Esterase of the alpha-beta hydrolase superfamily
B224_RS00525	COG1049	propionate catabolic process, 2-methylcitrate cycle
B224_RS00530	COG2200	EAL domain
B224_RS00540	COG1280	lysine exporter protein (LysE YggA)
B224_RS00550	COG0523	cobalamin synthesis protein
B224_RS00555	COG0477	Major facilitator Superfamily
B224_RS00570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B224_RS00575	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B224_RS00610	COG3385	transposase activity
B224_RS00635	COG5006	permease, DMT superfamily
B224_RS00640	COG1522	sequence-specific DNA binding
B224_RS00645	COG5433	transposase activity
B224_RS00650	COG0110	maltose O-acetyltransferase activity
B224_RS00655	COG0366	Alpha amylase catalytic
B224_RS00660	COG1263	PTS System
B224_RS00660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B224_RS00665	COG1609	Transcriptional regulator
B224_RS00675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B224_RS00680	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B224_RS00685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B224_RS00685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B224_RS00690	COG2723	6-phospho-beta-galactosidase activity
B224_RS00695	COG1447	Phosphotransferase system cellobiose-specific component IIA
B224_RS00700	COG1940	carbohydrate kinase activity
B224_RS00710	COG1609	Transcriptional regulator
B224_RS00720	COG0252	asparaginase activity
B224_RS00725	COG5433	transposase activity
B224_RS00740	COG1803	Methylglyoxal synthase
B224_RS00760	COG1444	tRNA N-acetyltransferase activity
B224_RS00765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B224_RS00770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B224_RS00775	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B224_RS00800	COG1612	heme a metabolic process
B224_RS00805	COG0109	protoheme IX farnesyltransferase activity
B224_RS00810	COG1012	belongs to the aldehyde dehydrogenase family
B224_RS00815	COG1177	transmembrane transport
B224_RS00820	COG1176	ABC-type spermidine putrescine transport system, permease component I
B224_RS00825	COG3842	ATPase activity
B224_RS00830	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B224_RS00835	COG0583	DNA-binding transcription factor activity
B224_RS00840	COG1757	Na H antiporter
B224_RS00880	COG0297	glycogen (starch) synthase activity
B224_RS00885	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B224_RS00890	COG2813	Specifically methylates the guanine in position
B224_RS00895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B224_RS00900	COG2203	Gaf domain
B224_RS00900	COG4251	negative regulation of phosphorylation
B224_RS00900	COG5001	Diguanylate cyclase
B224_RS00900	COG3706	GGDEF domain
B224_RS00905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B224_RS00915	COG2995	paraquat-inducible protein a
B224_RS00920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B224_RS00920	COG3008	intermembrane lipid transfer
B224_RS00925	COG3009	Protein conserved in bacteria
B224_RS00935	COG3240	lipase activity
B224_RS00950	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B224_RS00955	COG1194	a g-specific adenine glycosylase
B224_RS00965	COG3267	Type II secretory pathway component ExeA
B224_RS00965	COG3409	Peptidoglycan-binding domain 1 protein
B224_RS00970	COG0617	tRNA 3'-terminal CCA addition
B224_RS00975	COG0306	phosphate transporter
B224_RS00980	COG1392	Phosphate transport regulator
B224_RS00990	COG3133	Outer membrane lipoprotein
B224_RS01010	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B224_RS01015	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B224_RS01025	COG3031	protein transport across the cell outer membrane
B224_RS01035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B224_RS01040	COG1459	type II secretion system
B224_RS01045	COG2165	general secretion pathway protein
B224_RS01055	COG2165	general secretion pathway protein
B224_RS01060	COG4795	General secretion pathway protein
B224_RS01065	COG3156	type II secretion system protein K
B224_RS01075	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
B224_RS01090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B224_RS01100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B224_RS01110	COG1011	Hydrolase
B224_RS01115	COG0494	nUDIX hydrolase
B224_RS01120	COG1218	3'(2'),5'-bisphosphate nucleotidase
B224_RS01125	COG0814	amino acid
B224_RS01130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B224_RS01145	COG0626	cystathionine gamma-synthase activity
B224_RS01150	COG0460	homoserine dehydrogenase
B224_RS01150	COG0527	aspartate kinase activity
B224_RS01155	COG1346	cytolysis
B224_RS01160	COG1380	Effector of murein hydrolase LrgA
B224_RS01165	COG0583	DNA-binding transcription factor activity
B224_RS01205	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B224_RS01215	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B224_RS01220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B224_RS01230	COG0137	argininosuccinate synthase activity
B224_RS01235	COG0165	Argininosuccinate lyase
B224_RS01240	COG3039	Transposase
B224_RS01275	COG0110	maltose O-acetyltransferase activity
B224_RS01280	COG3174	membrane
B224_RS01285	COG1505	serine-type exopeptidase activity
B224_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
B224_RS01300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B224_RS01315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B224_RS01320	COG4991	sh3 domain protein
B224_RS01330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B224_RS01335	COG1940	carbohydrate kinase activity
B224_RS01340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B224_RS01345	COG0126	phosphoglycerate kinase activity
B224_RS01350	COG0191	fructose-bisphosphate aldolase activity
B224_RS01355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B224_RS01405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B224_RS01410	COG1595	DNA-templated transcription, initiation
B224_RS01430	COG0481	GTPase activity
B224_RS01435	COG0681	Belongs to the peptidase S26 family
B224_RS01440	COG0571	ribonuclease III activity
B224_RS01450	COG1381	Involved in DNA repair and RecF pathway recombination
B224_RS01455	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B224_RS01460	COG3023	N-Acetylmuramoyl-L-alanine amidase
B224_RS01465	COG4807	Protein conserved in bacteria
B224_RS01475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B224_RS01480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B224_RS01485	COG3956	TIGRFAM MazG family protein
B224_RS01490	COG0504	CTP synthase activity
B224_RS01495	COG0148	phosphopyruvate hydratase activity
B224_RS01500	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B224_RS01505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B224_RS01515	COG0585	pseudouridine synthase activity
B224_RS01520	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B224_RS01525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B224_RS01530	COG1238	metal cluster binding
B224_RS01535	COG1388	LysM domain
B224_RS01535	COG4942	peptidase
B224_RS01540	COG3039	Transposase
B224_RS01555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B224_RS01565	COG1610	YqeY-like protein
B224_RS01570	COG0358	DNA primase activity
B224_RS01575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B224_RS01600	COG0151	Belongs to the GarS family
B224_RS01605	COG0138	bifunctional purine biosynthesis protein purh
B224_RS01625	COG3036	rescue of stalled ribosome
B224_RS01630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B224_RS01635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B224_RS01645	COG0673	inositol 2-dehydrogenase activity
B224_RS01655	COG1585	Membrane protein implicated in regulation of membrane protease activity
B224_RS01660	COG0330	HflC and HflK could
B224_RS01665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B224_RS01665	COG1648	precorrin-2 dehydrogenase activity
B224_RS01670	COG0175	sulfate reduction
B224_RS01675	COG2895	sulfate adenylyltransferase (ATP) activity
B224_RS01680	COG3273	potassium ion transport
B224_RS01680	COG0471	metal ion transport
B224_RS01685	COG0529	Catalyzes the synthesis of activated sulfate
B224_RS01690	COG3039	Transposase
B224_RS01695	COG3385	transposase activity
B224_RS01705	COG0840	transmembrane signaling receptor activity
B224_RS01740	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
B224_RS01755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B224_RS01760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B224_RS01765	COG0163	prenyltransferase activity
B224_RS01780	COG1131	(ABC) transporter
B224_RS01785	COG0842	Transport permease protein
B224_RS01795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B224_RS01800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B224_RS01810	COG0617	tRNA 3'-terminal CCA addition
B224_RS01815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B224_RS01820	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B224_RS01830	COG1489	DNA binding
B224_RS01835	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B224_RS01840	COG1643	Atp-dependent helicase
B224_RS01845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B224_RS01850	COG0346	lactoylglutathione lyase activity
B224_RS01860	COG2076	Multidrug Resistance protein
B224_RS01865	COG0583	DNA-binding transcription factor activity
B224_RS01875	COG0671	phosphoesterase, PA-phosphatase related
B224_RS01890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B224_RS01895	COG0038	chloride channel
B224_RS01905	COG0316	Belongs to the HesB IscA family
B224_RS01940	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B224_RS01945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B224_RS01955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_RS01985	COG0745	RESPONSE REGULATOR receiver
B224_RS01990	COG3104	oligopeptide transport
B224_RS01995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B224_RS02000	COG1555	photosystem II stabilization
B224_RS02010	COG2350	Protein conserved in bacteria
B224_RS02015	COG2917	probably involved in intracellular septation
B224_RS02020	COG0076	glutamate decarboxylase activity
B224_RS02025	COG1272	protein, Hemolysin III
B224_RS02030	COG2985	domain, Protein
B224_RS02030	COG0569	domain protein
B224_RS02055	COG3039	Transposase
B224_RS02065	COG5433	transposase activity
B224_RS02070	COG5433	transposase activity
B224_RS02075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B224_RS02080	COG1376	ErfK ybiS ycfS ynhG family protein
B224_RS02085	COG0668	transmembrane transport
B224_RS02095	COG2731	YhcH YjgK YiaL family protein
B224_RS02105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B224_RS02110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B224_RS02125	COG5433	transposase activity
B224_RS02130	COG0583	DNA-binding transcription factor activity
B224_RS02135	COG0477	Major facilitator Superfamily
B224_RS02160	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B224_RS02170	COG0488	(ABC) transporter
B224_RS02175	COG0517	IMP dehydrogenase activity
B224_RS02185	COG3039	Transposase
B224_RS02190	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B224_RS02205	COG2755	lipolytic protein G-D-S-L family
B224_RS02210	COG4181	ATPase activity
B224_RS02215	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B224_RS02220	COG1090	epimerase
B224_RS02225	COG2200	EAL domain
B224_RS02230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B224_RS02235	COG4935	Belongs to the peptidase S8 family
B224_RS02235	COG2234	aminopeptidase activity
B224_RS02240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B224_RS02245	COG3171	Protein conserved in bacteria
B224_RS02250	COG2066	Belongs to the glutaminase family
B224_RS02255	COG2897	thiosulfate sulfurtransferase activity
B224_RS02265	COG1132	(ABC) transporter
B224_RS02285	COG3039	Transposase
B224_RS02295	COG1609	Transcriptional regulator
B224_RS02305	COG2017	converts alpha-aldose to the beta-anomer
B224_RS02310	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B224_RS02320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B224_RS02335	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
B224_RS02345	COG3706	GGDEF domain
B224_RS02345	COG4251	negative regulation of phosphorylation
B224_RS02345	COG2203	Gaf domain
B224_RS02345	COG5001	Diguanylate cyclase
B224_RS02355	COG3706	GGDEF domain
B224_RS02370	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B224_RS02385	COG4628	conserved protein (DUF2132)
B224_RS02390	COG0688	phosphatidylethanolamine metabolic process
B224_RS02400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B224_RS02435	COG1278	Cold shock
B224_RS02445	COG0840	transmembrane signaling receptor activity
B224_RS02450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B224_RS02495	COG0848	biopolymer transport protein
B224_RS02500	COG0811	peptide transport
B224_RS02505	COG0811	peptide transport
B224_RS02515	COG4206	TonB-dependent receptor
B224_RS02520	COG5433	transposase activity
B224_RS02525	COG4174	ABC transporter (Permease)
B224_RS02530	COG4239	(ABC) transporter, permease
B224_RS02535	COG0747	negative chemotaxis
B224_RS02540	COG0444	Belongs to the ABC transporter superfamily
B224_RS02545	COG4608	Belongs to the ABC transporter superfamily
B224_RS02550	COG2195	Cleaves the N-terminal amino acid of tripeptides
B224_RS02555	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B224_RS02560	COG1073	alpha beta
B224_RS02575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B224_RS02600	COG0243	molybdopterin cofactor binding
B224_RS02615	COG1116	anion transmembrane transporter activity
B224_RS02615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B224_RS02620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B224_RS02625	COG1116	anion transmembrane transporter activity
B224_RS02630	COG2146	nitrite reductase [NAD(P)H] activity
B224_RS02630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B224_RS02635	COG2146	nitrite reductase [NAD(P)H] activity
B224_RS02635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B224_RS02640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B224_RS02645	COG2313	pseudouridylate synthase activity
B224_RS02655	COG5433	transposase activity
B224_RS02660	COG1028	Short-chain dehydrogenase reductase Sdr
B224_RS02665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B224_RS02675	COG0521	Mo-molybdopterin cofactor biosynthetic process
B224_RS02695	COG2966	Psort location CytoplasmicMembrane, score
B224_RS02700	COG3610	response to peptide
B224_RS02710	COG4175	Glycine betaine
B224_RS02715	COG4176	ABC-type proline glycine betaine transport system permease component
B224_RS02720	COG2113	Glycine betaine
B224_RS02725	COG0175	sulfate reduction
B224_RS02730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B224_RS02735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B224_RS02740	COG0384	phenazine biosynthesis protein PhzF
B224_RS02745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B224_RS02750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B224_RS02760	COG5001	Diguanylate cyclase
B224_RS02770	COG0786	glutamate:sodium symporter activity
B224_RS02775	COG0252	asparaginase activity
B224_RS02780	COG3139	Protein of unknown function (DUF1315)
B224_RS02800	COG0616	signal peptide processing
B224_RS02805	COG0446	pyridine nucleotide-disulphide oxidoreductase
B224_RS02805	COG1902	pentaerythritol trinitrate reductase activity
B224_RS02810	COG0778	Nitroreductase
B224_RS02820	COG2264	protein methyltransferase activity
B224_RS02830	COG0583	DNA-binding transcription factor activity
B224_RS02835	COG2190	(PTS) system
B224_RS02835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B224_RS02835	COG1263	PTS System
B224_RS02840	COG4145	pantothenate transmembrane transporter activity
B224_RS02845	COG3924	membrane
B224_RS02850	COG0439	Biotin carboxylase
B224_RS02855	COG0511	ligase activity, forming carbon-carbon bonds
B224_RS02860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B224_RS02865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B224_RS02880	COG3381	protein complex oligomerization
B224_RS02890	COG3005	denitrification pathway
B224_RS02895	COG0745	RESPONSE REGULATOR receiver
B224_RS02905	COG1879	ABC-type sugar transport system periplasmic component
B224_RS02910	COG0784	Response regulator, receiver
B224_RS02910	COG2198	Histidine kinase
B224_RS02910	COG2205	protein histidine kinase activity
B224_RS02920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B224_RS02935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B224_RS02940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B224_RS02940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B224_RS02955	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B224_RS02960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B224_RS02965	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B224_RS02970	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B224_RS02975	COG4172	Belongs to the ABC transporter superfamily
B224_RS02985	COG0601	transmembrane transport
B224_RS02990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B224_RS02995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B224_RS03000	COG0142	geranyltranstransferase activity
B224_RS03005	COG1722	exodeoxyribonuclease VII activity
B224_RS03010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B224_RS03015	COG1360	Flagellar Motor Protein
B224_RS03030	COG1534	Rna-binding protein
B224_RS03035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B224_RS03045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B224_RS03050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B224_RS03055	COG0149	triose-phosphate isomerase activity
B224_RS03060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B224_RS03075	COG0779	Required for maturation of 30S ribosomal subunits
B224_RS03080	COG0195	Participates in both transcription termination and antitermination
B224_RS03085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B224_RS03090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B224_RS03095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B224_RS03100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B224_RS03105	COG1185	polyribonucleotide nucleotidyltransferase activity
B224_RS03115	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B224_RS03125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B224_RS03130	COG0826	peptidase U32
B224_RS03145	COG0312	modulator of DNA gyrase
B224_RS03160	COG4974	Belongs to the 'phage' integrase family
B224_RS03180	COG0180	Tryptophanyl-tRNA synthetase
B224_RS03190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B224_RS03195	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B224_RS03205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B224_RS03210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B224_RS03240	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B224_RS03245	COG0583	DNA-binding transcription factor activity
B224_RS03260	COG0583	DNA-binding transcription factor activity
B224_RS03275	COG3121	Chaperone
B224_RS03280	COG3188	usher protein
B224_RS03285	COG3121	Chaperone
B224_RS03295	COG0739	heme binding
B224_RS03305	COG3264	Mechanosensitive ion channel
B224_RS03305	COG1511	domain protein
B224_RS03310	COG0584	glycerophosphoryl diester phosphodiesterase
B224_RS03320	COG1053	succinate dehydrogenase
B224_RS03325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B224_RS03330	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
B224_RS03340	COG3214	Protein conserved in bacteria
B224_RS03345	COG4106	trans-aconitate 2-methyltransferase activity
B224_RS03365	COG0300	oxidoreductase activity
B224_RS03380	COG0642	Histidine kinase
B224_RS03395	COG0516	GMP reductase activity
B224_RS03405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B224_RS03410	COG3647	Membrane
B224_RS03420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B224_RS03430	COG3706	GGDEF domain
B224_RS03445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B224_RS03455	COG0583	DNA-binding transcription factor activity
B224_RS03460	COG1278	Cold shock
B224_RS03465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B224_RS03470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B224_RS03475	COG1702	phosphate starvation-inducible protein PhoH
B224_RS03480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B224_RS03485	COG4535	Mg2 and Co2 transporter CorC
B224_RS03490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B224_RS03495	COG2888	peptidyl-tyrosine sulfation
B224_RS03500	COG0495	leucyl-tRNA aminoacylation
B224_RS03515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B224_RS03520	COG0799	negative regulation of ribosome biogenesis
B224_RS03525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B224_RS03530	COG0768	penicillin binding
B224_RS03535	COG0772	Belongs to the SEDS family
B224_RS03540	COG2951	lytic endotransglycosylase activity
B224_RS03545	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B224_RS03550	COG1686	Belongs to the peptidase S11 family
B224_RS03555	COG2921	Belongs to the UPF0250 family
B224_RS03560	COG0321	lipoyl(octanoyl) transferase activity
B224_RS03565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B224_RS03575	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B224_RS03585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B224_RS03600	COG1970	mechanosensitive ion channel activity
B224_RS03620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B224_RS03630	COG1012	belongs to the aldehyde dehydrogenase family
B224_RS03640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B224_RS03655	COG0657	acetylesterase activity
B224_RS03660	COG3097	Belongs to the UPF0267 family
B224_RS03665	COG0490	domain, Protein
B224_RS03665	COG0471	metal ion transport
B224_RS03710	COG0012	GTP binding
B224_RS03715	COG0193	aminoacyl-tRNA hydrolase activity
B224_RS03720	COG0737	Belongs to the 5'-nucleotidase family
B224_RS03725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B224_RS03735	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B224_RS03740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B224_RS03745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B224_RS03750	COG2890	protein-(glutamine-N5) methyltransferase activity
B224_RS03760	COG2912	Transglutaminase-like superfamily
B224_RS03770	COG1301	dicarboxylic acid transport
B224_RS03780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B224_RS03800	COG5433	transposase activity
B224_RS03805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B224_RS03810	COG1115	amino acid carrier protein
B224_RS03830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B224_RS03840	COG0189	ligase activity
B224_RS03845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B224_RS03855	COG3091	SprT-like family
B224_RS03865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B224_RS03875	COG2801	Transposase and inactivated derivatives
B224_RS03890	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B224_RS03895	COG0739	heme binding
B224_RS03900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B224_RS03910	COG3408	Glycogen debranching enzyme
B224_RS03910	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B224_RS03920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B224_RS03925	COG0583	DNA-binding transcription factor activity
B224_RS03935	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B224_RS03945	COG0583	DNA-binding transcription factor activity
B224_RS03950	COG1028	Short-chain dehydrogenase reductase Sdr
B224_RS03955	COG0616	signal peptide processing
B224_RS03960	COG3724	N-succinylarginine dihydrolase activity
B224_RS03975	COG0840	transmembrane signaling receptor activity
B224_RS03985	COG2971	BadF BadG BcrA BcrD
B224_RS03995	COG4608	Belongs to the ABC transporter superfamily
B224_RS04000	COG0444	Belongs to the ABC transporter superfamily
B224_RS04005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B224_RS04020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B224_RS04025	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B224_RS04025	COG3064	Membrane
B224_RS04025	COG1073	alpha beta
B224_RS04035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B224_RS04050	COG3385	transposase activity
B224_RS04065	COG3385	transposase activity
B224_RS04075	COG3385	transposase activity
B224_RS04110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B224_RS04125	COG1136	(ABC) transporter
B224_RS04140	COG1309	transcriptional regulator
B224_RS04170	COG3039	Transposase
B224_RS04190	COG3385	transposase activity
B224_RS04200	COG2198	Histidine kinase
B224_RS04200	COG0643	Histidine kinase
B224_RS04200	COG0784	Response regulator, receiver
B224_RS04205	COG2201	protein-glutamate methylesterase activity
B224_RS04215	COG1360	Flagellar Motor Protein
B224_RS04220	COG1192	Involved in chromosome partitioning
B224_RS04230	COG0835	chemotaxis
B224_RS04245	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B224_RS04250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B224_RS04255	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B224_RS04260	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B224_RS04265	COG1138	Cytochrome C-type biogenesis protein
B224_RS04270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B224_RS04275	COG3088	subunit of a heme lyase
B224_RS04275	COG4235	cytochrome complex assembly
B224_RS04300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B224_RS04305	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B224_RS04305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B224_RS04320	COG0259	pyridoxamine-phosphate oxidase activity
B224_RS04370	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B224_RS04375	COG1763	Mo-molybdopterin cofactor biosynthetic process
B224_RS04380	COG0746	molybdenum cofactor guanylyltransferase activity
B224_RS04385	COG0281	malic enzyme
B224_RS04425	COG5433	transposase activity
B224_RS04430	COG5433	transposase activity
B224_RS04440	COG1129	ABC transporter
B224_RS04450	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_RS04455	COG1472	Belongs to the glycosyl hydrolase 3 family
B224_RS04470	COG3264	Mechanosensitive ion channel
B224_RS04470	COG1196	nuclear chromosome segregation
B224_RS04475	COG0469	pyruvate kinase activity
B224_RS04480	COG2850	peptidyl-arginine hydroxylation
B224_RS04485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B224_RS04490	COG2915	High frequency lysogenization protein hflD homolog
B224_RS04495	COG0482	sulfurtransferase activity
B224_RS04515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_RS04525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_RS04525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_RS04525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_RS04550	COG4932	domain protein
B224_RS04550	COG5492	domain, Protein
B224_RS04555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_RS04565	COG1482	cell wall glycoprotein biosynthetic process
B224_RS04570	COG2207	Transcriptional regulator
B224_RS04575	COG0538	isocitrate dehydrogenase activity
B224_RS04580	COG3385	transposase activity
B224_RS04585	COG3048	D-serine ammonia-lyase activity
B224_RS04590	COG2610	gluconate transmembrane transporter activity
B224_RS04595	COG0583	DNA-binding transcription factor activity
B224_RS04600	COG2916	Histone family protein nucleoid-structuring protein H-NS
B224_RS04605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B224_RS04610	COG2375	cellular response to nickel ion
B224_RS04620	COG0577	efflux transmembrane transporter activity
B224_RS04620	COG1136	(ABC) transporter
B224_RS04625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_RS04635	COG1227	inorganic diphosphatase activity
B224_RS04640	COG0497	DNA recombination
B224_RS04645	COG3706	GGDEF domain
B224_RS04650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B224_RS04655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B224_RS04660	COG0443	Heat shock 70 kDa protein
B224_RS04665	COG0484	heat shock protein binding
B224_RS04695	COG1285	pathogenesis
B224_RS04740	COG0095	Lipoate-protein ligase
B224_RS04755	COG0675	Transposase, IS605 OrfB family
B224_RS04770	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B224_RS04775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_RS04790	COG0708	Exodeoxyribonuclease III
B224_RS04815	COG0071	Belongs to the small heat shock protein (HSP20) family
B224_RS04850	COG0583	DNA-binding transcription factor activity
B224_RS04855	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B224_RS04865	COG5433	transposase activity
B224_RS04870	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B224_RS04875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B224_RS04880	COG1845	cytochrome c oxidase, subunit III
B224_RS04885	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B224_RS04890	COG0109	protoheme IX farnesyltransferase activity
B224_RS04895	COG2814	Major facilitator Superfamily
B224_RS04900	COG5507	3-demethylubiquinone-9 3-methyltransferase
B224_RS04935	COG3550	peptidyl-serine autophosphorylation
B224_RS04940	COG1396	sequence-specific DNA binding
B224_RS04945	COG5433	transposase activity
B224_RS04990	COG3385	transposase activity
B224_RS05005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B224_RS05015	COG0446	pyridine nucleotide-disulphide oxidoreductase
B224_RS05020	COG3039	Transposase
B224_RS05025	COG2271	Major facilitator Superfamily
B224_RS05065	COG2373	Large extracellular alpha-helical protein
B224_RS05070	COG4953	penicillin-binding protein 1C
B224_RS05080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B224_RS05080	COG0301	tRNA thio-modification
B224_RS05110	COG5433	transposase activity
B224_RS05120	COG3039	Transposase
B224_RS05135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B224_RS05145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B224_RS05160	COG0346	lactoylglutathione lyase activity
B224_RS05165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B224_RS05170	COG4660	Part of a membrane complex involved in electron transport
B224_RS05175	COG4659	FMN binding
B224_RS05180	COG4658	electron transport chain
B224_RS05185	COG4656	Part of a membrane complex involved in electron transport
B224_RS05190	COG2878	Part of a membrane complex involved in electron transport
B224_RS05195	COG4657	Part of a membrane complex involved in electron transport
B224_RS05200	COG0697	spore germination
B224_RS05220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B224_RS05225	COG1288	antiporter activity
B224_RS05230	COG0436	Aminotransferase
B224_RS05240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B224_RS05245	COG2027	D-alanyl-D-alanine carboxypeptidase
B224_RS05250	COG1061	Type III restriction enzyme res subunit
B224_RS05255	COG1566	PFAM secretion protein HlyD family protein
B224_RS05265	COG3264	Mechanosensitive ion channel
B224_RS05265	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B224_RS05270	COG1966	Carbon starvation protein
B224_RS05275	COG3279	Response regulator of the LytR AlgR family
B224_RS05280	COG3275	phosphorelay sensor kinase activity
B224_RS05290	COG1012	belongs to the aldehyde dehydrogenase family
B224_RS05290	COG1454	alcohol dehydrogenase
B224_RS05295	COG2095	MarC family integral membrane protein
B224_RS05305	COG0601	transmembrane transport
B224_RS05310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B224_RS05315	COG0444	Belongs to the ABC transporter superfamily
B224_RS05325	COG0861	Integral membrane protein TerC family
B224_RS05330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B224_RS05335	COG3385	transposase activity
B224_RS05345	COG1301	dicarboxylic acid transport
B224_RS05360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B224_RS05375	COG0537	adenosine 5'-monophosphoramidase activity
B224_RS05420	COG0675	Transposase, IS605 OrfB family
B224_RS05425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B224_RS05430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B224_RS05440	COG2354	Protein conserved in bacteria
B224_RS05455	COG3150	esterase
B224_RS05460	COG1252	NADH dehydrogenase
B224_RS05470	COG0393	Putative heavy-metal-binding
B224_RS05475	COG1619	proteins homologs of microcin C7 resistance protein MccF
B224_RS05485	COG1619	proteins homologs of microcin C7 resistance protein MccF
B224_RS05490	COG1368	sulfuric ester hydrolase activity
B224_RS05500	COG0527	aspartate kinase activity
B224_RS05505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B224_RS05505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B224_RS05510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B224_RS05525	COG2315	Protein conserved in bacteria
B224_RS05535	COG0583	DNA-binding transcription factor activity
B224_RS05540	COG1620	l-lactate permease
B224_RS05545	COG0247	lactate metabolic process
B224_RS05550	COG1139	Iron-sulfur cluster binding protein
B224_RS05565	COG3039	Transposase
B224_RS05575	COG0577	efflux transmembrane transporter activity
B224_RS05580	COG1136	(ABC) transporter
B224_RS05600	COG2814	Major facilitator Superfamily
B224_RS05625	COG0672	)-iron permease
B224_RS05660	COG2308	Evidence 4 Homologs of previously reported genes of
B224_RS05700	COG0582	viral genome integration into host DNA
B224_RS05755	COG0659	secondary active sulfate transmembrane transporter activity
B224_RS05770	COG3039	Transposase
B224_RS05775	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B224_RS05780	COG0326	Molecular chaperone. Has ATPase activity
B224_RS05790	COG0563	adenylate kinase activity
B224_RS05795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B224_RS05815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B224_RS05825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B224_RS05845	COG5001	Diguanylate cyclase
B224_RS05845	COG3300	MHYT domain
B224_RS05850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B224_RS05870	COG1021	2,3-dihydroxybenzoate-AMP ligase
B224_RS05875	COG1535	isochorismatase
B224_RS05875	COG3433	isochorismatase activity
B224_RS05885	COG3385	transposase activity
B224_RS05890	COG3433	isochorismatase activity
B224_RS05890	COG1535	isochorismatase
B224_RS05895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B224_RS05900	COG1028	Short-chain dehydrogenase reductase Sdr
B224_RS05910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B224_RS05915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B224_RS05925	COG1120	ATPase activity
B224_RS05930	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B224_RS05935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B224_RS05940	COG4771	TonB-dependent receptor
B224_RS05980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B224_RS05985	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B224_RS05990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B224_RS05995	COG0861	Integral membrane protein TerC family
B224_RS06010	COG1022	Amp-dependent synthetase and ligase
B224_RS06015	COG0295	cytidine deaminase activity
B224_RS06020	COG1346	cytolysis
B224_RS06025	COG1380	Effector of murein hydrolase LrgA
B224_RS06030	COG3345	alpha-galactosidase
B224_RS06040	COG2925	Exonuclease
B224_RS06045	COG0582	viral genome integration into host DNA
B224_RS06090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B224_RS06125	COG3646	Phage regulatory protein
B224_RS06165	COG4220	transposase activity
B224_RS06185	COG0740	serine-type endopeptidase activity
B224_RS06275	COG0392	lysyltransferase activity
B224_RS06275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B224_RS06290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B224_RS06295	COG0436	Aminotransferase
B224_RS06300	COG0583	DNA-binding transcription factor activity
B224_RS06305	COG2160	L-arabinose isomerase activity
B224_RS06315	COG1069	ribulokinase activity
B224_RS06320	COG1879	ABC-type sugar transport system periplasmic component
B224_RS06325	COG1129	ABC transporter
B224_RS06330	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_RS06340	COG3366	ferrous iron transmembrane transporter activity
B224_RS06345	COG0700	Nucleoside recognition
B224_RS06350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B224_RS06365	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_RS06375	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B224_RS06380	COG0254	rRNA binding
B224_RS06395	COG1451	nucleotide metabolic process
B224_RS06410	COG3069	C4-dicarboxylate transmembrane transporter activity
B224_RS06425	COG4584	PFAM Integrase catalytic
B224_RS06430	COG1484	DNA-dependent DNA replication
B224_RS06440	COG3385	transposase activity
B224_RS06450	COG3385	transposase activity
B224_RS06470	COG5433	transposase activity
B224_RS06485	COG3039	Transposase
B224_RS06490	COG5433	transposase activity
B224_RS06495	COG3385	transposase activity
B224_RS06500	COG5433	transposase activity
B224_RS06525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B224_RS06535	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
B224_RS06545	COG0724	RNA recognition motif
B224_RS06550	COG4989	oxidoreductase activity
B224_RS06575	COG3437	response regulator, receiver
B224_RS06580	COG0583	DNA-binding transcription factor activity
B224_RS06590	COG3300	MHYT domain
B224_RS06590	COG5001	Diguanylate cyclase
B224_RS06595	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B224_RS06600	COG0778	Nitroreductase
B224_RS06625	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B224_RS06630	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B224_RS06635	COG0539	negative regulation of cytoplasmic translation
B224_RS06640	COG0776	regulation of translation
B224_RS06650	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B224_RS06670	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B224_RS06675	COG0602	queuosine metabolic process
B224_RS06680	COG3530	Putative quorum-sensing-regulated virulence factor
B224_RS06685	COG2096	Adenosyltransferase
B224_RS06690	COG2916	Histone family protein nucleoid-structuring protein H-NS
B224_RS06695	COG5433	transposase activity
B224_RS06700	COG2916	Histone family protein nucleoid-structuring protein H-NS
B224_RS06705	COG1757	Na H antiporter
B224_RS06710	COG1435	thymidine kinase activity
B224_RS06775	COG2226	methyltransferase
B224_RS06800	COG3550	peptidyl-serine autophosphorylation
B224_RS06830	COG5433	transposase activity
B224_RS06905	COG5433	transposase activity
B224_RS06915	COG3039	Transposase
B224_RS06925	COG5433	transposase activity
B224_RS06945	COG0629	single-stranded DNA binding
B224_RS06950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B224_RS06955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B224_RS06970	COG1484	DNA-dependent DNA replication
B224_RS07055	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B224_RS07060	COG0626	cystathionine gamma-synthase activity
B224_RS07070	COG2910	NAD(P)H-binding
B224_RS07075	COG0583	DNA-binding transcription factor activity
B224_RS07085	COG2207	Transcriptional regulator
B224_RS07085	COG3708	Transcriptional regulator
B224_RS07090	COG4774	siderophore transport
B224_RS07110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B224_RS07115	COG0617	tRNA 3'-terminal CCA addition
B224_RS07115	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B224_RS07115	COG3620	sequence-specific DNA binding
B224_RS07130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B224_RS07135	COG3046	protein related to deoxyribodipyrimidine photolyase
B224_RS07145	COG4235	cytochrome complex assembly
B224_RS07145	COG3088	subunit of a heme lyase
B224_RS07150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B224_RS07155	COG1138	Cytochrome C-type biogenesis protein
B224_RS07160	COG3301	Polysulphide reductase, NrfD
B224_RS07165	COG0437	4 iron, 4 sulfur cluster binding
B224_RS07170	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
B224_RS07185	COG0247	lactate metabolic process
B224_RS07190	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
B224_RS07195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B224_RS07200	COG3012	SEC-C Motif Domain Protein
B224_RS07210	COG1846	Transcriptional regulator
B224_RS07210	COG1940	carbohydrate kinase activity
B224_RS07215	COG3290	protein histidine kinase activity
B224_RS07220	COG4565	transcriptional regulatory protein
B224_RS07240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B224_RS07245	COG0569	domain protein
B224_RS07245	COG2985	domain, Protein
B224_RS07260	COG0556	nucleotide-excision repair
B224_RS07270	COG0586	Pfam SNARE associated Golgi protein
B224_RS07275	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B224_RS07280	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B224_RS07290	COG2719	SpoVR family
B224_RS07295	COG2718	Belongs to the UPF0229 family
B224_RS07300	COG2766	serine protein kinase
B224_RS07305	COG0514	ATP-dependent DNA helicase (RecQ)
B224_RS07310	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B224_RS07315	COG0814	amino acid
B224_RS07320	COG5433	transposase activity
B224_RS07350	COG0058	SHG alpha-glucan phosphorylase activity
B224_RS07360	COG0471	metal ion transport
B224_RS07365	COG3118	belongs to the thioredoxin family
B224_RS07375	COG1132	(ABC) transporter
B224_RS07380	COG1132	(ABC) transporter
B224_RS07395	COG5433	transposase activity
B224_RS07410	COG2501	S4 domain
B224_RS07440	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B224_RS07445	COG2329	Antibiotic biosynthesis monooxygenase
B224_RS07450	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B224_RS07455	COG0673	inositol 2-dehydrogenase activity
B224_RS07460	COG0583	DNA-binding transcription factor activity
B224_RS07470	COG1560	Kdo2-lipid A biosynthetic process
B224_RS07475	COG1560	Kdo2-lipid A biosynthetic process
B224_RS07500	COG0417	DNA replication proofreading
B224_RS07540	COG0307	riboflavin synthase, alpha
B224_RS07550	COG0675	Transposase, IS605 OrfB family
B224_RS07560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B224_RS07565	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B224_RS07570	COG0697	spore germination
B224_RS07575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B224_RS07615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B224_RS07620	COG3099	Belongs to the UPF0263 family
B224_RS07625	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B224_RS07630	COG2894	cell division
B224_RS07635	COG0850	regulation of cytokinetic process
B224_RS07640	COG3100	YcgL domain-containing protein
B224_RS07645	COG2951	lytic endotransglycosylase activity
B224_RS07655	COG1760	l-serine dehydratase
B224_RS07660	COG1760	l-serine dehydratase
B224_RS07665	COG3123	guanosine phosphorylase activity
B224_RS07670	COG1301	dicarboxylic acid transport
B224_RS07685	COG2067	long-chain fatty acid transport protein
B224_RS07690	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B224_RS07695	COG2067	long-chain fatty acid transport protein
B224_RS07700	COG2067	long-chain fatty acid transport protein
B224_RS07720	COG2304	oxidoreductase activity
B224_RS07740	COG0714	Associated with various cellular activities
B224_RS07745	COG0183	Belongs to the thiolase family
B224_RS07750	COG1024	Enoyl-CoA hydratase
B224_RS07750	COG1250	3-hydroxyacyl-CoA dehydrogenase
B224_RS07755	COG4681	YaeQ
B224_RS07770	COG4372	Transposase
B224_RS07795	COG3328	transposase activity
B224_RS07820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B224_RS07835	COG3134	Outer membrane lipoprotein
B224_RS07840	COG0318	PFAM AMP-dependent synthetase and ligase
B224_RS07845	COG2378	regulation of single-species biofilm formation
B224_RS07855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B224_RS07855	COG0140	phosphoribosyl-ATP diphosphatase activity
B224_RS07860	COG0107	imidazoleglycerol-phosphate synthase activity
B224_RS07865	COG2205	protein histidine kinase activity
B224_RS07865	COG2198	Histidine kinase
B224_RS07865	COG0784	Response regulator, receiver
B224_RS07875	COG3437	response regulator, receiver
B224_RS07880	COG5433	transposase activity
B224_RS07890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B224_RS07895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B224_RS07900	COG0131	Imidazoleglycerol-phosphate dehydratase
B224_RS07900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B224_RS07905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B224_RS07910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B224_RS07915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B224_RS07925	COG1199	ATP-dependent helicase activity
B224_RS07930	COG1214	PFAM Peptidase M22, glycoprotease
B224_RS07950	COG0596	Alpha beta hydrolase
B224_RS07955	COG0318	PFAM AMP-dependent synthetase and ligase
B224_RS07960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B224_RS07970	COG0697	spore germination
B224_RS07980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B224_RS07985	COG2832	Protein of unknown function (DUF454)
B224_RS07990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B224_RS08000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B224_RS08005	COG1335	isochorismatase
B224_RS08020	COG3314	Sporulation integral membrane protein YlbJ
B224_RS08035	COG2197	response regulator
B224_RS08040	COG0617	tRNA 3'-terminal CCA addition
B224_RS08040	COG0517	IMP dehydrogenase activity
B224_RS08040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B224_RS08045	COG1643	Atp-dependent helicase
B224_RS08055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B224_RS08080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B224_RS08085	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B224_RS08090	COG0709	Synthesizes selenophosphate from selenide and ATP
B224_RS08100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B224_RS08105	COG0840	transmembrane signaling receptor activity
B224_RS08110	COG1254	Belongs to the acylphosphatase family
B224_RS08120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B224_RS08120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B224_RS08125	COG0489	protein tyrosine kinase activity
B224_RS08130	COG0572	uridine kinase
B224_RS08135	COG0717	Belongs to the dCTP deaminase family
B224_RS08140	COG0306	phosphate transporter
B224_RS08145	COG4584	PFAM Integrase catalytic
B224_RS08170	COG1530	ribonuclease E activity
B224_RS08180	COG0546	phosphoglycolate phosphatase activity
B224_RS08185	COG0424	maF-like protein
B224_RS08195	COG1399	metal-binding, possibly nucleic acid-binding protein
B224_RS08200	COG0416	fatty acid biosynthetic process
B224_RS08205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B224_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
B224_RS08220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B224_RS08230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B224_RS08235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B224_RS08240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B224_RS08245	COG0470	DNA polymerase III
B224_RS08250	COG0084	hydrolase, TatD family'
B224_RS08265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B224_RS08265	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B224_RS08270	COG3008	intermembrane lipid transfer
B224_RS08275	COG2995	paraquat-inducible protein a
B224_RS08285	COG3141	response to X-ray
B224_RS08295	COG1067	ATP-dependent peptidase activity
B224_RS08300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B224_RS08310	COG0488	(ABC) transporter
B224_RS08320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B224_RS08320	COG0116	Belongs to the methyltransferase superfamily
B224_RS08330	COG0167	dihydroorotate dehydrogenase activity
B224_RS08335	COG2902	Dehydrogenase
B224_RS08345	COG0308	aminopeptidase N
B224_RS08355	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
B224_RS08360	COG1956	GAF domain-containing protein
B224_RS08370	COG3278	Belongs to the heme-copper respiratory oxidase family
B224_RS08385	COG2010	Cytochrome c
B224_RS08410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B224_RS08415	COG0589	response to stress
B224_RS08420	COG0037	tRNA processing
B224_RS08435	COG0625	glutathione transferase activity
B224_RS08440	COG1869	D-ribose catabolic process
B224_RS08445	COG1129	ABC transporter
B224_RS08450	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_RS08455	COG1879	ABC-type sugar transport system periplasmic component
B224_RS08460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B224_RS08465	COG1609	Transcriptional regulator
B224_RS08470	COG3300	MHYT domain
B224_RS08470	COG5001	Diguanylate cyclase
B224_RS08495	COG2205	protein histidine kinase activity
B224_RS08495	COG0784	Response regulator, receiver
B224_RS08500	COG0776	regulation of translation
B224_RS08505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B224_RS08505	COG0072	phenylalanine-tRNA ligase activity
B224_RS08510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B224_RS08515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B224_RS08520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B224_RS08525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B224_RS08530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B224_RS08555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B224_RS08565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B224_RS08575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B224_RS08580	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B224_RS08585	COG3313	Fe-S protein
B224_RS08590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_RS08590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B224_RS08590	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B224_RS08595	COG1105	Belongs to the carbohydrate kinase PfkB family
B224_RS08600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_RS08600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_RS08605	COG1609	Transcriptional regulator
B224_RS08610	COG0814	amino acid
B224_RS08615	COG3788	relative of glutathione S-transferase, MAPEG superfamily
B224_RS08625	COG0513	Belongs to the DEAD box helicase family
B224_RS08635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B224_RS08640	COG2890	protein-(glutamine-N5) methyltransferase activity
B224_RS08645	COG2840	Smr protein MutS2
B224_RS08655	COG0406	alpha-ribazole phosphatase activity
B224_RS08685	COG2824	Alkylphosphonate utilization operon protein PhnA
B224_RS08735	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B224_RS08740	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
B224_RS08750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B224_RS08755	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B224_RS08765	COG0205	6-phosphofructokinase activity
B224_RS08770	COG1473	amidohydrolase
B224_RS08775	COG1011	Hydrolase
B224_RS08780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B224_RS08835	COG3593	DNA synthesis involved in DNA repair
B224_RS08850	COG0583	DNA-binding transcription factor activity
B224_RS08855	COG0730	response to heat
B224_RS08860	COG3148	PFAM DTW domain containing protein
B224_RS08870	COG1181	Belongs to the D-alanine--D-alanine ligase family
B224_RS08880	COG0386	Belongs to the glutathione peroxidase family
B224_RS08885	COG0513	Belongs to the DEAD box helicase family
B224_RS08900	COG1742	UPF0060 membrane protein
B224_RS08930	COG3039	Transposase
B224_RS08945	COG0583	DNA-binding transcription factor activity
B224_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
B224_RS08955	COG2723	6-phospho-beta-galactosidase activity
B224_RS08960	COG0583	DNA-binding transcription factor activity
B224_RS08965	COG3706	GGDEF domain
B224_RS08975	COG0243	molybdopterin cofactor binding
B224_RS08980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B224_RS08995	COG0583	DNA-binding transcription factor activity
B224_RS09000	COG1879	ABC-type sugar transport system periplasmic component
B224_RS09010	COG1879	ABC-type sugar transport system periplasmic component
B224_RS09015	COG1129	ABC transporter
B224_RS09020	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_RS09025	COG1172	Belongs to the binding-protein-dependent transport system permease family
B224_RS09055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B224_RS09065	COG2003	Belongs to the UPF0758 family
B224_RS09095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B224_RS09110	COG0730	response to heat
B224_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
B224_RS09130	COG1024	Enoyl-CoA hydratase
B224_RS09135	COG1024	Enoyl-CoA hydratase
B224_RS09140	COG1960	acyl-CoA dehydrogenase activity
B224_RS09150	COG1960	acyl-CoA dehydrogenase activity
B224_RS09155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B224_RS09160	COG1024	Enoyl-CoA hydratase
B224_RS09185	COG1584	GPR1 FUN34 yaaH family protein
B224_RS09200	COG1115	amino acid carrier protein
B224_RS09205	COG1024	Enoyl-CoA hydratase
B224_RS09220	COG3162	membrane
B224_RS09225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B224_RS09230	COG0488	(ABC) transporter
B224_RS09235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B224_RS09240	COG0776	regulation of translation
B224_RS09245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B224_RS09250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B224_RS09255	COG0740	serine-type endopeptidase activity
B224_RS09260	COG0544	peptidyl-prolyl cis-trans isomerase activity
B224_RS09270	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
B224_RS09275	COG4591	ABC-type transport system involved in lipoprotein release permease component
B224_RS09280	COG1136	(ABC) transporter
B224_RS09285	COG4591	ABC-type transport system involved in lipoprotein release permease component
B224_RS09295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B224_RS09300	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B224_RS09305	COG4166	transmembrane transport
B224_RS09310	COG0697	spore germination
B224_RS09320	COG2062	phosphohistidine phosphatase, SixA
B224_RS09350	COG0519	Catalyzes the synthesis of GMP from XMP
B224_RS09350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B224_RS09355	COG0517	IMP dehydrogenase activity
B224_RS09355	COG0516	GMP reductase activity
B224_RS09375	COG1874	Beta-galactosidase
B224_RS09375	COG0366	Alpha amylase catalytic
B224_RS09385	COG1570	exodeoxyribonuclease VII activity
B224_RS09395	COG2885	chlorophyll binding
B224_RS09400	COG2199	diguanylate cyclase activity
B224_RS09415	COG2154	pterin-4-alpha-carbinolamine dehydratase
B224_RS09425	COG3768	UPF0283 membrane protein
B224_RS09430	COG3106	COG3106 Predicted ATPase
B224_RS09445	COG1842	Phage shock protein A
B224_RS09450	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B224_RS09460	COG4168	peptide transport system, permease
B224_RS09465	COG4171	peptide transport system, permease
B224_RS09475	COG4172	Belongs to the ABC transporter superfamily
B224_RS09485	COG1609	Transcriptional regulator
B224_RS09490	COG1263	PTS System
B224_RS09490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B224_RS09495	COG2723	6-phospho-beta-galactosidase activity
B224_RS09500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B224_RS09505	COG1286	toxin biosynthetic process
B224_RS09510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B224_RS09515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B224_RS09520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B224_RS09525	COG1674	ftsk spoiiie
B224_RS09525	COG0531	amino acid
B224_RS09535	COG0686	Belongs to the AlaDH PNT family
B224_RS09540	COG0492	ferredoxin-NADP+ reductase activity
B224_RS09545	COG3706	GGDEF domain
B224_RS09550	COG3134	Outer membrane lipoprotein
B224_RS09555	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B224_RS09560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B224_RS09565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B224_RS09570	COG0542	response to heat
B224_RS09575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B224_RS09580	COG1278	Cold shock
B224_RS09585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B224_RS09605	COG1944	ATP diphosphatase activity
B224_RS09610	COG2116	formate transmembrane transporter activity
B224_RS09615	COG1882	Formate acetyltransferase
B224_RS09620	COG2983	Belongs to the UPF0260 family
B224_RS09630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B224_RS09635	COG0045	succinate-CoA ligase (ADP-forming) activity
B224_RS09640	COG0508	dehydrogenase complex catalyzes the overall conversion of
B224_RS09645	COG0567	Dehydrogenase, E1 component
B224_RS09655	COG1053	succinate dehydrogenase
B224_RS09660	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B224_RS09685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B224_RS09690	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B224_RS09690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B224_RS09710	COG5433	transposase activity
B224_RS09720	COG3385	transposase activity
B224_RS09730	COG1484	DNA-dependent DNA replication
B224_RS09735	COG4584	PFAM Integrase catalytic
B224_RS09750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B224_RS09755	COG1360	Flagellar Motor Protein
B224_RS09765	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B224_RS09770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B224_RS09775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B224_RS09775	COG0649	NAD binding
B224_RS09790	COG1034	ATP synthesis coupled electron transport
B224_RS09795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B224_RS09800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B224_RS09805	COG0839	Belongs to the complex I subunit 6 family
B224_RS09810	COG0713	ATP synthesis coupled electron transport
B224_RS09820	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B224_RS09825	COG1007	ATP synthesis coupled electron transport
B224_RS09830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B224_RS09830	COG0047	phosphoribosylformylglycinamidine synthase activity
B224_RS09835	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B224_RS09845	COG1160	GTP binding
B224_RS09850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B224_RS09855	COG2976	Protein conserved in bacteria
B224_RS09860	COG0124	histidyl-tRNA synthetase
B224_RS09880	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B224_RS09885	COG0105	UTP biosynthetic process
B224_RS09890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B224_RS09900	COG0633	Ferredoxin
B224_RS09905	COG0443	Heat shock 70 kDa protein
B224_RS09910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B224_RS09920	COG0822	iron-sulfur transferase activity
B224_RS09925	COG1104	cysteine desulfurase activity
B224_RS09945	COG3154	lipid carrier protein
B224_RS09950	COG0826	peptidase U32
B224_RS09955	COG0826	peptidase U32
B224_RS09970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B224_RS09975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B224_RS09980	COG1862	Preprotein translocase
B224_RS09985	COG0343	queuine tRNA-ribosyltransferase activity
B224_RS09990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B224_RS09995	COG0517	IMP dehydrogenase activity
B224_RS10005	COG3634	alkyl hydroperoxide reductase activity
B224_RS10080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B224_RS10080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B224_RS10085	COG0509	glycine decarboxylation via glycine cleavage system
B224_RS10090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B224_RS10095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B224_RS10100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B224_RS10120	COG2814	Major facilitator Superfamily
B224_RS10130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B224_RS10135	COG0601	transmembrane transport
B224_RS10145	COG0625	glutathione transferase activity
B224_RS10160	COG0483	inositol monophosphate 1-phosphatase activity
B224_RS10185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B224_RS10190	COG2056	Na+-H+ antiporter family
B224_RS10195	COG2814	Major facilitator Superfamily
B224_RS10200	COG0583	DNA-binding transcription factor activity
B224_RS10205	COG0513	Belongs to the DEAD box helicase family
B224_RS10210	COG2050	protein possibly involved in aromatic compounds catabolism
B224_RS10220	COG0277	FAD linked oxidase domain protein
B224_RS10220	COG0247	lactate metabolic process
B224_RS10230	COG1253	flavin adenine dinucleotide binding
B224_RS10235	COG1902	pentaerythritol trinitrate reductase activity
B224_RS10240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B224_RS10245	COG0647	UMP catabolic process
B224_RS10255	COG0367	asparagine synthase
B224_RS10265	COG0625	glutathione transferase activity
B224_RS10295	COG0564	pseudouridine synthase activity
B224_RS10300	COG3706	GGDEF domain
B224_RS10310	COG0840	transmembrane signaling receptor activity
B224_RS10315	COG0318	PFAM AMP-dependent synthetase and ligase
B224_RS10335	COG4447	cellulose binding
B224_RS10360	COG2855	membrane
B224_RS10370	COG2814	Major facilitator Superfamily
B224_RS10375	COG3246	L-lysine catabolic process to acetate
B224_RS10380	COG2175	clavaminate synthase activity
B224_RS10390	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B224_RS10415	COG0670	Belongs to the BI1 family
B224_RS10420	COG1289	transmembrane transporter activity
B224_RS10425	COG2920	part of a sulfur-relay system
B224_RS10430	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
B224_RS10435	COG0285	dihydrofolate synthase activity
B224_RS10440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B224_RS10445	COG0101	tRNA pseudouridine synthase activity
B224_RS10455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B224_RS10460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B224_RS10465	COG0671	phosphoesterase, PA-phosphatase related
B224_RS10470	COG1464	Belongs to the NlpA lipoprotein family
B224_RS10475	COG3039	Transposase
B224_RS10490	COG1119	ATPase activity
B224_RS10495	COG1484	DNA-dependent DNA replication
B224_RS10500	COG4584	PFAM Integrase catalytic
B224_RS10505	COG2801	Transposase and inactivated derivatives
B224_RS10515	COG1119	ATPase activity
B224_RS10520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B224_RS10520	COG0574	Belongs to the PEP-utilizing enzyme family
B224_RS10525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B224_RS10530	COG1113	amino acid transport
B224_RS10575	COG1242	4 iron, 4 sulfur cluster binding
B224_RS10585	COG0067	glutamate synthase
B224_RS10585	COG0069	glutamate synthase activity
B224_RS10585	COG0070	glutamate synthase
B224_RS10590	COG0493	'glutamate synthase
B224_RS10600	COG0789	Transcriptional regulator
B224_RS10615	COG4104	PAAR repeat-containing protein
B224_RS10625	COG0513	Belongs to the DEAD box helicase family
B224_RS10655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B224_RS10660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B224_RS10665	COG0505	Belongs to the CarA family
B224_RS10670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B224_RS10680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B224_RS10685	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B224_RS10690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B224_RS10695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B224_RS10700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B224_RS10705	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
B224_RS10755	COG2119	membrane
B224_RS10790	COG2203	Gaf domain
B224_RS10790	COG2199	diguanylate cyclase activity
B224_RS10795	COG5433	transposase activity
B224_RS10800	COG3039	Transposase
B224_RS10810	COG5433	transposase activity
B224_RS10825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B224_RS10835	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B224_RS10840	COG2261	transglycosylase associated protein
B224_RS10845	COG0625	glutathione transferase activity
B224_RS10875	COG5433	transposase activity
B224_RS10920	COG0322	excinuclease ABC activity
B224_RS10925	COG2197	response regulator
B224_RS10930	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B224_RS10935	COG2835	tetraacyldisaccharide 4'-kinase activity
B224_RS10940	COG1663	tetraacyldisaccharide 4'-kinase activity
B224_RS10945	COG1132	(ABC) transporter
B224_RS10950	COG2333	competence protein COMEC
B224_RS10950	COG0658	competence protein
B224_RS10990	COG2731	YhcH YjgK YiaL family protein
B224_RS11000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B224_RS11005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B224_RS11045	COG0443	Heat shock 70 kDa protein
B224_RS11050	COG2003	Belongs to the UPF0758 family
B224_RS11060	COG2801	Transposase and inactivated derivatives
B224_RS11065	COG4584	PFAM Integrase catalytic
B224_RS11080	COG1484	DNA-dependent DNA replication
B224_RS11105	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B224_RS11155	COG0675	Transposase, IS605 OrfB family
B224_RS11215	COG3385	transposase activity
B224_RS11230	COG2026	Addiction module toxin, RelE StbE family
B224_RS11240	COG0658	competence protein
B224_RS11240	COG2333	competence protein COMEC
B224_RS11270	COG0433	COG0433 Predicted ATPase
B224_RS11280	COG1448	Aminotransferase
B224_RS11295	COG1199	ATP-dependent helicase activity
B224_RS11305	COG0123	including yeast histone deacetylase and acetoin utilization protein
B224_RS11310	COG0477	Major facilitator Superfamily
B224_RS11315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B224_RS11320	COG1785	Belongs to the alkaline phosphatase family
B224_RS11340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B224_RS11345	COG2197	response regulator
B224_RS11355	COG2271	Major facilitator Superfamily
B224_RS11365	COG0675	Transposase, IS605 OrfB family
B224_RS11380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_RS11385	COG0765	amino acid transport
B224_RS11390	COG1126	abc transporter atp-binding protein
B224_RS11400	COG3385	transposase activity
B224_RS11405	COG0531	amino acid
B224_RS11420	COG1253	flavin adenine dinucleotide binding
B224_RS11425	COG0704	Plays a role in the regulation of phosphate uptake
B224_RS11430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B224_RS11435	COG0581	inorganic phosphate transmembrane transporter activity
B224_RS11440	COG0573	inorganic phosphate transmembrane transporter activity
B224_RS11465	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B224_RS11490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B224_RS11495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B224_RS11500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B224_RS11530	COG2716	regulation of RNA biosynthetic process
B224_RS11535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B224_RS11545	COG0675	Transposase, IS605 OrfB family
B224_RS11580	COG1705	Flagellar rod assembly protein muramidase FlgJ
B224_RS11580	COG3951	Flagellar rod assembly protein muramidase FlgJ
B224_RS11585	COG1706	bacterial-type flagellum-dependent cell motility
B224_RS11590	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B224_RS11620	COG1815	bacterial-type flagellum-dependent cell motility
B224_RS11625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B224_RS11630	COG0784	Response regulator, receiver
B224_RS11630	COG0835	chemotaxis
B224_RS11635	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
B224_RS11650	COG0622	Phosphoesterase
B224_RS11655	COG4166	transmembrane transport
B224_RS11665	COG1187	pseudouridine synthase activity
B224_RS11675	COG0675	Transposase, IS605 OrfB family
B224_RS11695	COG0697	spore germination
B224_RS11725	COG1278	Cold shock
B224_RS11765	COG3132	Protein of unknown function, DUF480
B224_RS11780	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B224_RS11800	COG2801	Transposase and inactivated derivatives
B224_RS11815	COG3206	protein involved in exopolysaccharide biosynthesis
B224_RS11815	COG0489	protein tyrosine kinase activity
B224_RS11820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B224_RS11830	COG3039	Transposase
B224_RS11845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B224_RS11850	COG3385	transposase activity
B224_RS11870	COG1091	dTDP-4-dehydrorhamnose reductase activity
B224_RS11895	COG1737	Transcriptional regulator
B224_RS11900	COG0469	pyruvate kinase activity
B224_RS11910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B224_RS11915	COG1960	acyl-CoA dehydrogenase activity
B224_RS11925	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B224_RS11940	COG3039	Transposase
B224_RS11950	COG5433	transposase activity
B224_RS11960	COG3657	addiction module killer protein
B224_RS11980	COG1484	DNA-dependent DNA replication
B224_RS11985	COG4584	PFAM Integrase catalytic
B224_RS12010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B224_RS12015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_RS12020	COG1309	transcriptional regulator
B224_RS12035	COG1946	Acyl-CoA thioesterase
B224_RS12045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B224_RS12055	COG0009	L-threonylcarbamoyladenylate synthase
B224_RS12065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B224_RS12070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B224_RS12070	COG0512	Glutamine amidotransferase of anthranilate synthase
B224_RS12075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B224_RS12080	COG0134	indole-3-glycerol-phosphate synthase activity
B224_RS12080	COG0135	phosphoribosylanthranilate isomerase activity
B224_RS12085	COG0133	tryptophan synthase activity
B224_RS12090	COG0159	tryptophan synthase activity
B224_RS12125	COG0438	transferase activity, transferring glycosyl groups
B224_RS12125	COG1216	Glycosyl transferase, family 2
B224_RS12135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B224_RS12145	COG1091	dTDP-4-dehydrorhamnose reductase activity
B224_RS12170	COG4160	amino acid transport
B224_RS12180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_RS12190	COG2431	L-lysine efflux transmembrane transporter activity
B224_RS12195	COG3385	transposase activity
B224_RS12200	COG0675	Transposase, IS605 OrfB family
B224_RS12215	COG1393	Belongs to the ArsC family
B224_RS12225	COG4783	chaperone-mediated protein folding
B224_RS12245	COG0675	Transposase, IS605 OrfB family
B224_RS12270	COG3842	ATPase activity
B224_RS12275	COG3833	ABC-type maltose transport systems, permease component
B224_RS12280	COG1175	transmembrane transport
B224_RS12285	COG2182	Extracellular solute-binding protein
B224_RS12290	COG3081	Nucleoid-associated protein
B224_RS12295	COG3082	Protein of unknown function (DUF1414)
B224_RS12300	COG3083	sulfuric ester hydrolase activity
B224_RS12305	COG4206	TonB-dependent receptor
B224_RS12310	COG1770	oligopeptidase
B224_RS12330	COG4574	serine-type endopeptidase inhibitor activity
B224_RS12335	COG3085	chromosome segregation
B224_RS12345	COG0287	Prephenate dehydrogenase
B224_RS12345	COG1605	Chorismate mutase
B224_RS12350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B224_RS12355	COG0584	glycerophosphoryl diester phosphodiesterase
B224_RS12365	COG1349	DNA-binding transcription factor activity
B224_RS12370	COG2271	Major facilitator Superfamily
B224_RS12380	COG5433	transposase activity
B224_RS12390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B224_RS12395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B224_RS12400	COG0583	DNA-binding transcription factor activity
B224_RS12425	COG0656	L-ascorbic acid biosynthetic process
B224_RS12430	COG2814	Major facilitator Superfamily
B224_RS12440	COG1294	oxidase, subunit
B224_RS12450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B224_RS12465	COG1595	DNA-templated transcription, initiation
B224_RS12485	COG2979	Protein of unknown function (DUF533)
B224_RS12520	COG1187	pseudouridine synthase activity
B224_RS12525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B224_RS12545	COG1061	Type III restriction enzyme res subunit
B224_RS12570	COG1166	arginine decarboxylase activity
B224_RS12580	COG2195	Cleaves the N-terminal amino acid of tripeptides
B224_RS12595	COG0675	Transposase, IS605 OrfB family
B224_RS12600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B224_RS12615	COG0583	DNA-binding transcription factor activity
B224_RS12625	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B224_RS12630	COG0840	transmembrane signaling receptor activity
B224_RS12635	COG0302	gtp cyclohydrolase
B224_RS12645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B224_RS12650	COG0596	Alpha beta hydrolase
B224_RS12655	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B224_RS12670	COG0314	molybdopterin synthase activity
B224_RS12675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B224_RS12680	COG0315	cyclic pyranopterin monophosphate synthase activity
B224_RS12685	COG0521	Mo-molybdopterin cofactor biosynthetic process
B224_RS12690	COG3005	denitrification pathway
B224_RS12700	COG0348	domain, Protein
B224_RS12705	COG0437	4 iron, 4 sulfur cluster binding
B224_RS12710	COG0243	molybdopterin cofactor binding
B224_RS12720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B224_RS12725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B224_RS12730	COG3850	Histidine kinase
B224_RS12735	COG2197	response regulator
B224_RS12760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B224_RS12770	COG0121	glutamine amidotransferase
B224_RS12775	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B224_RS12780	COG1960	acyl-CoA dehydrogenase activity
B224_RS12785	COG3437	response regulator, receiver
B224_RS12785	COG0784	Response regulator, receiver
B224_RS12795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B224_RS12800	COG0328	RNA-DNA hybrid ribonuclease activity
B224_RS12805	COG2226	methyltransferase
B224_RS12810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B224_RS12815	COG0741	lytic transglycosylase activity
B224_RS12815	COG1388	LysM domain
B224_RS12830	COG1607	acyl-coa hydrolase
B224_RS12845	COG0741	lytic transglycosylase activity
B224_RS12855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B224_RS12880	COG0729	surface antigen
B224_RS12890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B224_RS12900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B224_RS12910	COG4134	Bacterial extracellular solute-binding protein
B224_RS12920	COG4136	ATPase activity
B224_RS12925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B224_RS12930	COG2951	lytic endotransglycosylase activity
B224_RS12935	COG1846	Transcriptional regulator
B224_RS12945	COG0033	Phosphoglucomutase
B224_RS12950	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
B224_RS12955	COG0596	Alpha beta hydrolase
B224_RS12970	COG0716	FMN binding
B224_RS12980	COG0735	belongs to the Fur family
B224_RS12985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B224_RS12995	COG2190	(PTS) system
B224_RS12995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B224_RS12995	COG1263	PTS System
B224_RS13000	COG0363	glucosamine-6-phosphate deaminase activity
B224_RS13005	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B224_RS13010	COG1846	Transcriptional regulator
B224_RS13010	COG1940	carbohydrate kinase activity
B224_RS13020	COG0217	transcriptional regulatory protein
B224_RS13025	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B224_RS13030	COG1801	Protein of unknown function DUF72
B224_RS13035	COG4106	trans-aconitate 2-methyltransferase activity
B224_RS13040	COG0500	methyltransferase
B224_RS13060	COG0583	DNA-binding transcription factor activity
B224_RS13065	COG0791	NLP P60 protein
B224_RS13080	COG1309	transcriptional regulator
B224_RS13115	COG0534	Mate efflux family protein
B224_RS13125	COG2841	Protein conserved in bacteria
B224_RS13130	COG0674	pyruvate-flavodoxin oxidoreductase activity
B224_RS13130	COG1013	pyruvate-flavodoxin oxidoreductase activity
B224_RS13130	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B224_RS13130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B224_RS13140	COG0633	Ferredoxin
B224_RS13140	COG3217	Mosc domain protein beta barrel domain protein
B224_RS13140	COG3217	Mosc domain protein beta barrel domain protein
B224_RS13140	COG0633	Ferredoxin
B224_RS13145	COG0501	Belongs to the peptidase M48B family
B224_RS13150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B224_RS13155	COG1073	alpha beta
B224_RS13155	COG2226	methyltransferase
B224_RS13160	COG0156	8-amino-7-oxononanoate synthase activity
B224_RS13165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B224_RS13185	COG0017	Asparaginyl-tRNA synthetase
B224_RS13190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B224_RS13210	COG1393	Belongs to the ArsC family
B224_RS13215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B224_RS13220	COG1876	peptidase activity
B224_RS13225	COG3263	regulation of cellular component size
B224_RS13240	COG1280	lysine exporter protein (LysE YggA)
B224_RS13270	COG0564	pseudouridine synthase activity
B224_RS13285	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B224_RS13290	COG0702	epimerase
B224_RS13295	COG2914	Belongs to the UPF0125 (RnfH) family
B224_RS13300	COG2867	negative regulation of translational initiation
B224_RS13305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B224_RS13310	COG0582	viral genome integration into host DNA
B224_RS13340	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B224_RS13370	COG3153	acetyltransferase
B224_RS13410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B224_RS13420	COG0745	RESPONSE REGULATOR receiver
B224_RS13435	COG4988	ABC transporter
B224_RS13440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B224_RS13460	COG1720	tRNA m6t6A37 methyltransferase activity
B224_RS13475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B224_RS13480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B224_RS13485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_RS13495	COG2190	(PTS) system
B224_RS13500	COG3038	cytochrome b561
B224_RS13515	COG0420	3'-5' exonuclease activity
B224_RS13520	COG0456	acetyltransferase
B224_RS13525	COG2974	May be involved in recombination
B224_RS13535	COG0405	Gamma-glutamyltransferase
B224_RS13545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B224_RS13550	COG1396	sequence-specific DNA binding
B224_RS13550	COG1917	Cupin 2, conserved barrel domain protein
B224_RS13565	COG0531	amino acid
B224_RS13575	COG0531	amino acid
B224_RS13585	COG1283	sodium-dependent phosphate transmembrane transporter activity
B224_RS13595	COG3384	dioxygenase
B224_RS13600	COG2205	protein histidine kinase activity
B224_RS13600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_RS13630	COG0784	Response regulator, receiver
B224_RS13630	COG2205	protein histidine kinase activity
B224_RS13675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B224_RS13685	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B224_RS13700	COG4263	nitrous-oxide reductase activity
B224_RS13705	COG0348	domain, Protein
B224_RS13705	COG3901	Regulator of nitric oxide reductase transcription
B224_RS13710	COG5433	transposase activity
B224_RS13715	COG3901	Regulator of nitric oxide reductase transcription
B224_RS13715	COG0348	domain, Protein
B224_RS13730	COG1376	ErfK ybiS ycfS ynhG family protein
B224_RS13730	COG1388	LysM domain
B224_RS13745	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
B224_RS13750	COG0791	NLP P60 protein
B224_RS13760	COG3118	belongs to the thioredoxin family
B224_RS13770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B224_RS13775	COG0788	formyltetrahydrofolate deformylase activity
B224_RS13800	COG0739	heme binding
B224_RS13800	COG1196	nuclear chromosome segregation
B224_RS13800	COG0741	lytic transglycosylase activity
B224_RS13810	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B224_RS13815	COG0673	inositol 2-dehydrogenase activity
B224_RS13840	COG1032	radical SAM domain protein
B224_RS13845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B224_RS13855	COG3706	GGDEF domain
B224_RS13860	COG1752	Esterase of the alpha-beta hydrolase superfamily
B224_RS13865	COG0733	neurotransmitter:sodium symporter activity
B224_RS13900	COG0281	malic enzyme
B224_RS13910	COG0534	Mate efflux family protein
B224_RS13925	COG2233	PERMEase
B224_RS13930	COG0095	Lipoate-protein ligase
B224_RS13935	COG1115	amino acid carrier protein
B224_RS13945	COG0019	diaminopimelate decarboxylase activity
B224_RS13955	COG0678	peroxiredoxin activity
B224_RS13960	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B224_RS13970	COG1126	abc transporter atp-binding protein
B224_RS13975	COG0765	amino acid transport
B224_RS13985	COG0765	amino acid transport
B224_RS13990	COG4597	amino acid ABC transporter
B224_RS13995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_RS14010	COG1131	(ABC) transporter
B224_RS14015	COG0545	Peptidyl-prolyl cis-trans isomerase
B224_RS14020	COG3142	Participates in the control of copper homeostasis
B224_RS14045	COG5002	protein histidine kinase activity
B224_RS14050	COG0745	RESPONSE REGULATOR receiver
B224_RS14055	COG0346	lactoylglutathione lyase activity
B224_RS14060	COG3706	GGDEF domain
B224_RS14065	COG3284	Transcriptional regulator
B224_RS14080	COG0697	spore germination
B224_RS14090	COG3290	protein histidine kinase activity
B224_RS14095	COG0281	malic enzyme
B224_RS14110	COG1566	PFAM secretion protein HlyD family protein
B224_RS14140	COG0602	queuosine metabolic process
B224_RS14145	COG1328	CTP reductase activity
B224_RS14155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B224_RS14160	COG3115	cell septum assembly
B224_RS14165	COG1196	nuclear chromosome segregation
B224_RS14175	COG2860	membrane
B224_RS14185	COG3108	Peptidase M15
B224_RS14190	COG2989	Protein conserved in bacteria
B224_RS14205	COG0463	Glycosyl transferase, family 2
B224_RS14220	COG0366	Alpha amylase catalytic
B224_RS14255	COG3706	GGDEF domain
B224_RS14260	COG0037	tRNA processing
B224_RS14265	COG3590	peptidase
B224_RS14275	COG0488	(ABC) transporter
B224_RS14290	COG0531	amino acid
B224_RS14295	COG0814	amino acid
B224_RS14300	COG0583	DNA-binding transcription factor activity
B224_RS14310	COG3385	transposase activity
B224_RS14315	COG0825	malonyl-CoA metabolic process
B224_RS14325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B224_RS14330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B224_RS14335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B224_RS14340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B224_RS14345	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B224_RS14360	COG0750	zinc metalloprotease
B224_RS14365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B224_RS14370	COG0575	Belongs to the CDS family
B224_RS14375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B224_RS14380	COG0233	cytoplasmic translational termination
B224_RS14385	COG0528	UMP kinase activity
B224_RS14390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B224_RS14395	COG0052	Belongs to the universal ribosomal protein uS2 family
B224_RS14400	COG0024	Methionine aminopeptidase
B224_RS14405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B224_RS14410	COG2171	N-acyltransferase activity
B224_RS14420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B224_RS14420	COG1263	PTS System
B224_RS14440	COG0564	pseudouridine synthase activity
B224_RS14445	COG3098	single-species biofilm formation
B224_RS14470	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
B224_RS14480	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B224_RS14480	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B224_RS14495	COG1611	Belongs to the LOG family
B224_RS14500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B224_RS14505	COG0473	3-isopropylmalate dehydrogenase activity
B224_RS14515	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B224_RS14520	COG2363	Small membrane protein
B224_RS14530	COG0583	DNA-binding transcription factor activity
B224_RS14535	COG0840	transmembrane signaling receptor activity
B224_RS14540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B224_RS14555	COG1477	protein flavinylation
B224_RS14560	COG2871	sodium ion transport
B224_RS14565	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B224_RS14570	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B224_RS14575	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B224_RS14580	COG1805	sodium ion transport
B224_RS14585	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B224_RS14590	COG0271	Belongs to the BolA IbaG family
B224_RS14595	COG2813	Specifically methylates the guanine in position
B224_RS14605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B224_RS14615	COG2211	Major facilitator Superfamily
B224_RS14620	COG3248	Nucleoside-binding outer membrane protein
B224_RS14625	COG1666	GTP binding
B224_RS14645	COG3039	Transposase
B224_RS14685	COG2771	luxR family
B224_RS14690	COG0659	secondary active sulfate transmembrane transporter activity
B224_RS14720	COG1393	Belongs to the ArsC family
B224_RS14725	COG0798	PFAM Bile acid sodium symporter
B224_RS14735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B224_RS14760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B224_RS14765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B224_RS14770	COG1151	hydroxylamine reductase activity
B224_RS14775	COG0783	Belongs to the Dps family
B224_RS14800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B224_RS14815	COG0300	oxidoreductase activity
B224_RS14830	COG0789	Transcriptional regulator
B224_RS14835	COG3272	Protein of unknown function (DUF1722)
B224_RS14860	COG1605	Chorismate mutase
B224_RS14860	COG0077	Prephenate dehydratase
B224_RS14885	COG4580	involved in the transport of maltose and maltodextrins
B224_RS14890	COG5433	transposase activity
B224_RS14905	COG5433	transposase activity
B224_RS14910	COG3385	transposase activity
B224_RS14915	COG3940	Belongs to the glycosyl hydrolase 43 family
B224_RS14930	COG1175	transmembrane transport
B224_RS14960	COG2133	pyrroloquinoline quinone binding
B224_RS14965	COG1349	DNA-binding transcription factor activity
B224_RS14970	COG2084	Dehydrogenase
B224_RS14975	COG3395	kinase activity
B224_RS14980	COG0235	Class ii aldolase
B224_RS14985	COG3622	Belongs to the hyi family
B224_RS14990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B224_RS14995	COG2610	gluconate transmembrane transporter activity
B224_RS15015	COG0300	oxidoreductase activity
B224_RS15035	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B224_RS15055	COG3813	Protein conserved in bacteria
B224_RS15065	COG0826	peptidase U32
B224_RS15070	COG1280	lysine exporter protein (LysE YggA)
B224_RS15080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B224_RS15105	COG2200	EAL domain
B224_RS15105	COG2203	Gaf domain
B224_RS15105	COG2199	diguanylate cyclase activity
B224_RS15145	COG0114	fumarate hydratase activity
B224_RS15155	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B224_RS15155	COG0506	proline dehydrogenase activity
B224_RS15155	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B224_RS15165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B224_RS15180	COG0737	Belongs to the 5'-nucleotidase family
B224_RS15205	COG0545	Peptidyl-prolyl cis-trans isomerase
B224_RS15220	COG1047	Peptidyl-prolyl cis-trans
B224_RS15225	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B224_RS15235	COG0784	Response regulator, receiver
B224_RS15235	COG0835	chemotaxis
B224_RS15240	COG0429	hydrolase of the alpha beta-hydrolase fold
B224_RS15250	COG3089	Belongs to the UPF0270 family
B224_RS15255	COG3954	Phosphoribulokinase
B224_RS15270	COG1765	OsmC-like protein
B224_RS15300	COG2205	protein histidine kinase activity
B224_RS15305	COG2814	Major facilitator Superfamily
B224_RS15340	COG0748	coenzyme F420 binding
B224_RS15345	COG3721	Heme iron utilization protein
B224_RS15355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B224_RS15385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B224_RS15395	COG0463	Glycosyl transferase, family 2
B224_RS15400	COG0741	lytic transglycosylase activity
B224_RS15405	COG0488	(ABC) transporter
B224_RS15415	COG2252	PERMEase
B224_RS15425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B224_RS15430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B224_RS15435	COG3178	'Phosphotransferase
B224_RS15440	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B224_RS15450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B224_RS15455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B224_RS15460	COG2967	ApaG domain
B224_RS15465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B224_RS15475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B224_RS15480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B224_RS15485	COG3314	Sporulation integral membrane protein YlbJ
B224_RS15490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B224_RS15495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B224_RS15505	COG0142	geranyltranstransferase activity
B224_RS15510	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
B224_RS15515	COG0330	HflC and HflK could
B224_RS15520	COG0330	HflC and HflK could
B224_RS15525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B224_RS15530	COG1923	regulation of RNA biosynthetic process
B224_RS15535	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B224_RS15540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B224_RS15550	COG0802	atpase or kinase
B224_RS15555	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B224_RS15555	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B224_RS15575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B224_RS15580	COG2011	ABC-type metal ion transport system permease component
B224_RS15585	COG1464	Belongs to the NlpA lipoprotein family
B224_RS15600	COG0840	transmembrane signaling receptor activity
B224_RS15645	COG5001	Diguanylate cyclase
B224_RS15645	COG3300	MHYT domain
B224_RS15655	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B224_RS15660	COG0784	Response regulator, receiver
B224_RS15660	COG5002	protein histidine kinase activity
B224_RS15660	COG2198	Histidine kinase
B224_RS15695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B224_RS15700	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B224_RS15705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B224_RS15710	COG2716	regulation of RNA biosynthetic process
B224_RS15715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B224_RS15720	COG3013	Belongs to the UPF0304 family
B224_RS15730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B224_RS15735	COG0857	belongs to the CobB CobQ family
B224_RS15735	COG0280	phosphate acetyltransferase
B224_RS15740	COG0440	acetolactate synthase activity
B224_RS15745	COG0028	Belongs to the TPP enzyme family
B224_RS15750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B224_RS15755	COG0671	phosphoesterase, PA-phosphatase related
B224_RS15765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B224_RS15770	COG0473	3-isopropylmalate dehydrogenase activity
B224_RS15775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B224_RS15780	COG0066	3-isopropylmalate dehydratase activity
B224_RS15795	COG4143	(ABC) transporter
B224_RS15800	COG1178	ABC-type Fe3 transport system permease component
B224_RS15805	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B224_RS15810	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B224_RS15850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B224_RS15855	COG0564	pseudouridine synthase activity
B224_RS15875	COG0459	protein refolding
B224_RS15880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B224_RS15885	COG0534	Mate efflux family protein
B224_RS15890	COG3030	protein affecting phage T7 exclusion by the F plasmid
B224_RS15895	COG1027	Aspartate ammonia-lyase
B224_RS15900	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B224_RS15905	COG2918	glutathione biosynthetic process
B224_RS15910	COG0612	Peptidase, M16
B224_RS15915	COG1238	metal cluster binding
B224_RS15920	COG1064	alcohol dehydrogenase
B224_RS15945	COG0359	binds to the 23S rRNA
B224_RS15950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B224_RS15955	COG0360	Binds together with S18 to 16S ribosomal RNA
B224_RS15960	COG1914	H( )-stimulated, divalent metal cation uptake system
B224_RS15975	COG2153	protein acetylation
B224_RS15985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B224_RS15990	COG0557	exoribonuclease II activity
B224_RS15995	COG3706	GGDEF domain
B224_RS16000	COG1854	S-ribosylhomocysteine lyase activity
B224_RS16015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B224_RS16015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B224_RS16025	COG5433	transposase activity
B224_RS16035	COG1484	DNA-dependent DNA replication
B224_RS16040	COG4584	PFAM Integrase catalytic
B224_RS16050	COG3385	transposase activity
B224_RS16070	COG5433	transposase activity
B224_RS16090	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B224_RS16095	COG1047	Peptidyl-prolyl cis-trans
B224_RS16100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B224_RS16105	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B224_RS16110	COG0196	riboflavin kinase activity
B224_RS16115	COG0728	peptidoglycan biosynthetic process
B224_RS16120	COG0268	Binds directly to 16S ribosomal RNA
B224_RS16125	COG0640	Transcriptional regulator
B224_RS16130	COG0583	DNA-binding transcription factor activity
B224_RS16140	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B224_RS16145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B224_RS16150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B224_RS16160	COG1051	belongs to the nudix hydrolase family
B224_RS16175	COG0335	large ribosomal subunit rRNA binding
B224_RS16180	COG0336	Belongs to the RNA methyltransferase TrmD family
B224_RS16185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B224_RS16190	COG0228	four-way junction DNA binding
B224_RS16195	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B224_RS16200	COG4137	Cytochrome C assembly protein
B224_RS16205	COG4536	flavin adenine dinucleotide binding
B224_RS16215	COG1017	nitric oxide dioxygenase activity
B224_RS16215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B224_RS16220	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
B224_RS16225	COG0039	L-malate dehydrogenase activity
B224_RS16230	COG4160	amino acid transport
B224_RS16235	COG4215	(ABC) transporter
B224_RS16240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_RS16245	COG1126	abc transporter atp-binding protein
B224_RS16250	COG1438	arginine binding
B224_RS16255	COG2837	iron assimilation
B224_RS16270	COG1840	ABC-type Fe3 transport system, periplasmic component
B224_RS16275	COG0347	Belongs to the P(II) protein family
B224_RS16290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B224_RS16295	COG0583	DNA-binding transcription factor activity
B224_RS16310	COG1929	Belongs to the glycerate kinase type-1 family
B224_RS16315	COG2610	gluconate transmembrane transporter activity
B224_RS16320	COG3835	regulator
B224_RS16325	COG3112	Uncharacterised protein family (UPF0231)
B224_RS16345	COG1872	DUF167
B224_RS16350	COG0762	integral membrane protein
B224_RS16355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B224_RS16360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B224_RS16375	COG3022	response to hydroperoxide
B224_RS16380	COG0513	Belongs to the DEAD box helicase family
B224_RS16385	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B224_RS16405	COG0735	belongs to the Fur family
B224_RS16410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B224_RS16420	COG0776	regulation of translation
B224_RS16425	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
B224_RS16435	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B224_RS16450	COG0560	Phosphoserine phosphatase
B224_RS16460	COG3064	Membrane
B224_RS16475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B224_RS16480	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B224_RS16485	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B224_RS16495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B224_RS16500	COG0084	hydrolase, TatD family'
B224_RS16515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B224_RS16520	COG0004	ammonium transporteR
B224_RS16530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_RS16540	COG0438	transferase activity, transferring glycosyl groups
B224_RS16555	COG1401	restriction endodeoxyribonuclease activity
B224_RS16570	COG3385	transposase activity
B224_RS16610	COG0582	viral genome integration into host DNA
B224_RS16625	COG0795	lipopolysaccharide-transporting ATPase activity
B224_RS16630	COG0795	lipopolysaccharide-transporting ATPase activity
B224_RS16635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B224_RS16640	COG2927	DNA polymerase III (CHI subunit)
B224_RS16650	COG1253	flavin adenine dinucleotide binding
B224_RS16655	COG0586	Pfam SNARE associated Golgi protein
B224_RS16660	COG1686	Belongs to the peptidase S11 family
B224_RS16695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B224_RS16700	COG0527	aspartate kinase activity
B224_RS16705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B224_RS16720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B224_RS16725	COG1546	Belongs to the CinA family
B224_RS16735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B224_RS16755	COG3068	Protein conserved in bacteria
B224_RS16765	COG0739	heme binding
B224_RS16795	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B224_RS16800	COG1121	(ABC) transporter
B224_RS16805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B224_RS16810	COG0583	DNA-binding transcription factor activity
B224_RS16820	COG1573	uracil-dna glycosylase
B224_RS16830	COG2827	Endonuclease containing a URI domain
B224_RS16845	COG1842	Phage shock protein A
B224_RS16850	COG0204	Acyl-transferase
B224_RS16870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B224_RS16950	COG3039	Transposase
B224_RS16970	COG1051	belongs to the nudix hydrolase family
B224_RS16975	COG3150	esterase
B224_RS16985	COG3151	Protein conserved in bacteria
B224_RS16990	COG0494	nUDIX hydrolase
B224_RS16995	COG1538	Outer membrane efflux protein
B224_RS17000	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B224_RS17000	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B224_RS17005	COG1560	Kdo2-lipid A biosynthetic process
B224_RS17040	COG2771	luxR family
B224_RS17055	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
B224_RS17065	COG4584	PFAM Integrase catalytic
B224_RS17070	COG1484	DNA-dependent DNA replication
B224_RS17075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B224_RS17075	COG2213	PTS system mannitol-specific
B224_RS17080	COG0246	Mannitol dehydrogenase
B224_RS17085	COG3722	fumarate hydratase activity
B224_RS17110	COG1671	Belongs to the UPF0178 family
B224_RS17125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B224_RS17130	COG5433	transposase activity
B224_RS17135	COG0513	Belongs to the DEAD box helicase family
B224_RS17165	COG1575	Belongs to the MenA family. Type 1 subfamily
B224_RS17170	COG1169	isochorismate synthase
B224_RS17175	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B224_RS17180	COG0596	Alpha beta hydrolase
B224_RS17185	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B224_RS17190	COG1441	menaquinone biosynthetic process
B224_RS17195	COG0318	PFAM AMP-dependent synthetase and ligase
B224_RS17200	COG3291	Pkd domain containing protein
B224_RS17205	COG2949	membrane
B224_RS17210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B224_RS17220	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B224_RS17245	COG2873	o-acetylhomoserine
B224_RS17260	COG1979	alcohol dehydrogenase
B224_RS17275	COG4221	oxidoreductase activity
B224_RS17305	COG1368	sulfuric ester hydrolase activity
B224_RS17330	COG3047	cAMP biosynthetic process
B224_RS17340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B224_RS17345	COG2197	response regulator
B224_RS17370	COG1278	Cold shock
B224_RS17400	COG3706	GGDEF domain
B224_RS17405	COG0347	Belongs to the P(II) protein family
B224_RS17410	COG0004	ammonium transporteR
B224_RS17420	COG0346	lactoylglutathione lyase activity
B224_RS17425	COG5433	transposase activity
B224_RS17435	COG3039	Transposase
B224_RS17440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B224_RS17445	COG1074	ATP-dependent DNA helicase activity
B224_RS17450	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B224_RS17455	COG2259	Doxx family
B224_RS17460	COG1741	Belongs to the pirin family
B224_RS17470	COG0583	DNA-binding transcription factor activity
B224_RS17495	COG1176	ABC-type spermidine putrescine transport system, permease component I
B224_RS17505	COG3842	ATPase activity
B224_RS17515	COG2203	Gaf domain
B224_RS17515	COG2199	diguanylate cyclase activity
B224_RS17530	COG2207	Transcriptional regulator
B224_RS17535	COG0456	acetyltransferase
B224_RS17535	COG0454	-acetyltransferase
B224_RS17540	COG0753	catalase activity
B224_RS17565	COG0628	permease
B224_RS17575	COG3284	Transcriptional regulator
B224_RS17590	COG1461	Dihydroxyacetone kinase
B224_RS17595	COG2376	Dihydroxyacetone kinase
B224_RS17600	COG2252	PERMEase
B224_RS17610	COG4584	PFAM Integrase catalytic
B224_RS17615	COG1484	DNA-dependent DNA replication
B224_RS17655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B224_RS17660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B224_RS17665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B224_RS17670	COG0049	tRNA binding
B224_RS17680	COG2168	tRNA wobble position uridine thiolation
B224_RS17700	COG2964	Protein conserved in bacteria
B224_RS17705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B224_RS17710	COG0085	RNA polymerase activity
B224_RS17715	COG0222	ribosome binding
B224_RS17720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B224_RS17725	COG0081	regulation of translation
B224_RS17730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B224_RS17735	COG0250	Participates in transcription elongation, termination and antitermination
B224_RS17750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B224_RS17775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B224_RS17780	COG0569	domain protein
B224_RS17785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B224_RS17790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B224_RS17795	COG3005	denitrification pathway
B224_RS17800	COG0243	molybdopterin cofactor binding
B224_RS17830	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B224_RS17845	COG2204	response regulator
B224_RS17855	COG2205	protein histidine kinase activity
B224_RS17870	COG0516	GMP reductase activity
B224_RS17870	COG0517	IMP dehydrogenase activity
B224_RS17875	COG5413	integral membrane protein
B224_RS17895	COG1522	sequence-specific DNA binding
B224_RS17900	COG2502	aspartate--ammonia ligase
B224_RS17905	COG0542	response to heat
B224_RS17915	COG0564	pseudouridine synthase activity
B224_RS17920	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B224_RS17925	COG0446	pyridine nucleotide-disulphide oxidoreductase
B224_RS17935	COG3681	Belongs to the UPF0597 family
B224_RS17940	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B224_RS17945	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B224_RS17950	COG1979	alcohol dehydrogenase
B224_RS17955	COG2207	Transcriptional regulator
B224_RS17960	COG3040	lipid binding
B224_RS17975	COG0688	phosphatidylethanolamine metabolic process
B224_RS17990	COG0540	Belongs to the ATCase OTCase family
B224_RS17995	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B224_RS18000	COG1438	arginine binding
B224_RS18005	COG1288	antiporter activity
B224_RS18010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B224_RS18030	COG3385	transposase activity
B224_RS18045	COG4211	Belongs to the binding-protein-dependent transport system permease family
B224_RS18060	COG3250	beta-galactosidase activity
B224_RS18065	COG1609	Transcriptional regulator
B224_RS18070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B224_RS18080	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B224_RS18085	COG2017	converts alpha-aldose to the beta-anomer
B224_RS18090	COG0667	Aldo Keto reductase
B224_RS18095	COG1968	undecaprenyl-diphosphatase activity
B224_RS18100	COG3806	Anti-sigma factor
B224_RS18105	COG1595	DNA-templated transcription, initiation
B224_RS18115	COG0018	arginyl-trna synthetase
B224_RS18125	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B224_RS18130	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B224_RS18150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_RS18155	COG1131	(ABC) transporter
B224_RS18160	COG0842	Transport permease protein
B224_RS18165	COG0842	Transport permease protein
B224_RS18170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B224_RS18180	COG2116	formate transmembrane transporter activity
B224_RS18185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B224_RS18185	COG1648	precorrin-2 dehydrogenase activity
B224_RS18190	COG2239	Acts as a magnesium transporter
B224_RS18195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B224_RS18200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B224_RS18210	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B224_RS18220	COG0514	ATP-dependent DNA helicase (RecQ)
B224_RS18225	COG2050	protein possibly involved in aromatic compounds catabolism
B224_RS18245	COG2258	MOSC domain
B224_RS18250	COG1177	transmembrane transport
B224_RS18255	COG1176	ABC-type spermidine putrescine transport system, permease component I
B224_RS18260	COG3842	ATPase activity
B224_RS18280	COG0174	glutamine synthetase
B224_RS18305	COG3045	CreA protein
B224_RS18310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B224_RS18315	COG0443	Heat shock 70 kDa protein
B224_RS18330	COG0366	Alpha amylase catalytic
B224_RS18345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B224_RS18350	COG0745	RESPONSE REGULATOR receiver
B224_RS18355	COG2205	protein histidine kinase activity
B224_RS18365	COG0281	malic enzyme
B224_RS18370	COG0702	epimerase
B224_RS18375	COG0254	rRNA binding
B224_RS18380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B224_RS18390	COG3039	Transposase
B224_RS18395	COG5433	transposase activity
B224_RS18410	COG0129	dihydroxy-acid dehydratase activity
B224_RS18420	COG3978	acetolactate synthase activity
B224_RS18430	COG0606	chelatase, subunit chli
B224_RS18435	COG0204	Acyl-transferase
B224_RS18440	COG0204	Acyl-transferase
B224_RS18445	COG1683	Conserved Protein
B224_RS18455	COG1335	isochorismatase
B224_RS18465	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B224_RS18470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B224_RS18475	COG3639	organic phosphonate transmembrane transporter activity
B224_RS18480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B224_RS18485	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B224_RS18495	COG3084	Protein conserved in bacteria
B224_RS18500	COG2203	Gaf domain
B224_RS18500	COG3706	GGDEF domain
B224_RS18500	COG4251	negative regulation of phosphorylation
B224_RS18500	COG5001	Diguanylate cyclase
B224_RS18505	COG0789	Transcriptional regulator
B224_RS18515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B224_RS18520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B224_RS18525	COG1561	YicC-like family, N-terminal region
B224_RS18535	COG1519	Transferase
B224_RS18540	COG0859	PFAM glycosyl transferase family 9
B224_RS18545	COG0463	Glycosyl transferase, family 2
B224_RS18550	COG0859	PFAM glycosyl transferase family 9
B224_RS18555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B224_RS18560	COG2990	Protein conserved in bacteria
B224_RS18565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B224_RS18575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B224_RS18580	COG2003	Belongs to the UPF0758 family
B224_RS18585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B224_RS18590	COG0756	dUTP diphosphatase activity
B224_RS18595	COG1309	transcriptional regulator
B224_RS18600	COG0668	transmembrane transport
B224_RS18610	COG0166	Belongs to the GPI family
B224_RS18615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B224_RS18620	COG0583	DNA-binding transcription factor activity
B224_RS18630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B224_RS18630	COG1042	CoA-binding domain protein
B224_RS18630	COG0045	succinate-CoA ligase (ADP-forming) activity
B224_RS18665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B224_RS18675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B224_RS18680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B224_RS18685	COG2223	nitrite transmembrane transporter activity
B224_RS18690	COG3279	Response regulator of the LytR AlgR family
B224_RS18695	COG3275	phosphorelay sensor kinase activity
B224_RS18705	COG2223	nitrite transmembrane transporter activity
B224_RS18710	COG2081	HI0933 family
B224_RS18715	COG1528	Iron-storage protein
B224_RS18720	COG3706	GGDEF domain
B224_RS18725	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B224_RS18730	COG0589	response to stress
B224_RS18765	COG3642	lipopolysaccharide core region biosynthetic process
B224_RS18770	COG0859	PFAM glycosyl transferase family 9
B224_RS18780	COG1758	RNA polymerase activity
B224_RS18785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B224_RS18790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B224_RS18795	COG2267	carboxylic ester hydrolase activity
B224_RS18800	COG0561	phosphatase activity
B224_RS18830	COG1309	transcriptional regulator
B224_RS18835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B224_RS18840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B224_RS18845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B224_RS18845	COG4191	Histidine kinase
B224_RS18850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B224_RS18860	COG0604	alcohol dehydrogenase
B224_RS18870	COG1733	regulation of RNA biosynthetic process
B224_RS18890	COG2205	protein histidine kinase activity
B224_RS18895	COG0745	RESPONSE REGULATOR receiver
B224_RS18900	COG2814	Major facilitator Superfamily
B224_RS18915	COG3977	Valine--pyruvate aminotransferase
B224_RS18920	COG0071	Belongs to the small heat shock protein (HSP20) family
B224_RS18925	COG0071	Belongs to the small heat shock protein (HSP20) family
B224_RS18930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B224_RS18940	COG2378	regulation of single-species biofilm formation
B224_RS18950	COG0187	DNA topoisomerase II activity
B224_RS18960	COG0592	DNA-directed DNA polymerase activity
B224_RS18965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B224_RS18980	COG1126	abc transporter atp-binding protein
B224_RS18985	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B224_RS18990	COG0594	ribonuclease P activity
B224_RS18995	COG0706	membrane insertase activity
B224_RS19000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B224_RS19005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B224_RS19010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B224_RS19015	COG1120	ATPase activity
B224_RS19020	COG4615	Cyclic peptide transporter
B224_RS19025	COG4774	siderophore transport
B224_RS19030	COG0716	FMN binding
B224_RS19035	COG0445	tRNA wobble uridine modification
B224_RS19040	COG0357	Ribosomal RNA small subunit methyltransferase G
B224_RS19045	COG1192	Involved in chromosome partitioning
B224_RS19050	COG1475	DNA binding
B224_RS19060	COG0356	it plays a direct role in the translocation of protons across the membrane
B224_RS19070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B224_RS19075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B224_RS19080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B224_RS19085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B224_RS19090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B224_RS19095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B224_RS19100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B224_RS19105	COG4452	Inner membrane protein CreD
B224_RS19115	COG2205	protein histidine kinase activity
B224_RS19120	COG0745	RESPONSE REGULATOR receiver
B224_RS19125	COG1349	DNA-binding transcription factor activity
B224_RS19130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B224_RS19135	COG2771	luxR family
B224_RS19145	COG0811	peptide transport
B224_RS19150	COG0811	peptide transport
B224_RS19155	COG0848	biopolymer transport protein
B224_RS19160	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
B224_RS19200	COG1609	Transcriptional regulator
B224_RS19205	COG3250	beta-galactosidase activity
B224_RS19210	COG2731	YhcH YjgK YiaL family protein
B224_RS19215	COG0531	amino acid
B224_RS19220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B224_RS19225	COG0531	amino acid
B224_RS19230	COG0385	Bile acid
B224_RS19235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B224_RS19255	COG0583	DNA-binding transcription factor activity
B224_RS19270	COG1079	Belongs to the binding-protein-dependent transport system permease family
B224_RS19275	COG4603	Belongs to the binding-protein-dependent transport system permease family
B224_RS19280	COG3845	ABC transporter
B224_RS19285	COG1744	ABC transporter substrate-binding protein PnrA-like
B224_RS19290	COG0210	DNA helicase
B224_RS19315	COG2391	methyltransferase activity
B224_RS19320	COG1280	lysine exporter protein (LysE YggA)
B224_RS19330	COG2962	Rard protein
B224_RS19345	COG1012	belongs to the aldehyde dehydrogenase family
B224_RS19350	COG1396	sequence-specific DNA binding
B224_RS19355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B224_RS19365	COG0519	Catalyzes the synthesis of GMP from XMP
B224_RS19365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B224_RS19375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B224_RS19395	COG1322	Protein conserved in bacteria
B224_RS19400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B224_RS19405	COG0569	domain protein
B224_RS19410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B224_RS19410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B224_RS19415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B224_RS19420	COG0242	peptide deformylase activity
B224_RS19430	COG0758	DNA mediated transformation
B224_RS19435	COG2922	Belongs to the Smg family
B224_RS19440	COG0551	DNA topoisomerase type I activity
B224_RS19445	COG0009	L-threonylcarbamoyladenylate synthase
B224_RS19450	COG0408	coproporphyrinogen oxidase activity
B224_RS19455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B224_RS19460	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B224_RS19470	COG3078	GTPase activator activity
B224_RS19480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B224_RS19485	COG5433	transposase activity
B224_RS19490	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B224_RS19500	COG3852	Histidine kinase
B224_RS19510	COG0174	glutamine synthetase
B224_RS19515	COG1217	gtp-binding protein TYPA
B224_RS19520	COG1295	ribonuclease BN
B224_RS19525	COG1295	ribonuclease BN
B224_RS19530	COG1490	D-aminoacyl-tRNA deacylase activity
B224_RS19540	COG0456	acetyltransferase
B224_RS19550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B224_RS19555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B224_RS19560	COG2610	gluconate transmembrane transporter activity
B224_RS19565	COG3265	gluconokinase activity
B224_RS19570	COG0129	dihydroxy-acid dehydratase activity
B224_RS19575	COG0800	Aldolase
B224_RS19580	COG1609	Transcriptional regulator
B224_RS19590	COG4942	peptidase
B224_RS19595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B224_RS19600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B224_RS19605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B224_RS19610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B224_RS19615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B224_RS19615	COG0316	Belongs to the HesB IscA family
B224_RS19620	COG1040	competence protein
B224_RS19625	COG0596	Alpha beta hydrolase
B224_RS19640	COG2183	response to ionizing radiation
B224_RS19645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B224_RS19655	COG2205	protein histidine kinase activity
B224_RS19665	COG0051	transcription antitermination factor activity, RNA binding
B224_RS19670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B224_RS19675	COG0088	Forms part of the polypeptide exit tunnel
B224_RS19680	COG0089	rRNA binding
B224_RS19685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B224_RS19690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B224_RS19695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B224_RS19700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B224_RS19705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B224_RS19710	COG0255	Belongs to the universal ribosomal protein uL29 family
B224_RS19715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B224_RS19720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B224_RS19725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B224_RS19730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B224_RS19735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B224_RS19740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B224_RS19745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B224_RS19750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B224_RS19755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B224_RS19760	COG0200	Binds to the 23S rRNA
B224_RS19765	COG0201	protein transport
B224_RS19770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B224_RS19775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B224_RS19780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B224_RS19785	COG0202	RNA polymerase activity
B224_RS19790	COG0203	ribosomal protein L17
B224_RS19795	COG1484	DNA-dependent DNA replication
B224_RS19800	COG4584	PFAM Integrase catalytic
B224_RS19830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B224_RS19835	COG0402	S-adenosylhomocysteine deaminase activity
B224_RS19840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B224_RS19845	COG2226	methyltransferase
B224_RS19850	COG3165	ubiquinone biosynthetic process from chorismate
B224_RS19855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B224_RS19860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B224_RS19865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B224_RS19870	COG0805	protein transport
B224_RS19875	COG0084	hydrolase, TatD family'
B224_RS19895	COG0742	ribosomal rna small subunit methyltransferase
B224_RS19910	COG0248	Ppx GppA phosphatase
B224_RS19915	COG0513	Belongs to the DEAD box helicase family
B224_RS19920	COG3118	belongs to the thioredoxin family
B224_RS19935	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B224_RS19950	COG2960	long-chain fatty acid transporting porin activity
B224_RS19965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B224_RS20005	COG1609	Transcriptional regulator
B224_RS20010	COG3604	Transcriptional regulator
B224_RS20015	COG1773	rubredoxin
B224_RS20015	COG0426	domain, Protein
B224_RS20020	COG0446	pyridine nucleotide-disulphide oxidoreductase
B224_RS20030	COG0348	domain, Protein
B224_RS20035	COG3033	Beta-eliminating lyase
B224_RS20040	COG5433	transposase activity
B224_RS20045	COG0814	amino acid
B224_RS20050	COG0814	amino acid
B224_RS20060	COG0751	glycine-tRNA ligase activity
B224_RS20065	COG0752	glycyl-tRNA synthetase alpha subunit
B224_RS20095	COG2885	chlorophyll binding
B224_RS20100	COG0251	oxidation-reduction process
B224_RS20105	COG0425	Belongs to the sulfur carrier protein TusA family
B224_RS20115	COG1653	transport
B224_RS20130	COG0183	Belongs to the thiolase family
B224_RS20135	COG1250	3-hydroxyacyl-CoA dehydrogenase
B224_RS20135	COG1024	Enoyl-CoA hydratase
B224_RS20140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B224_RS20145	COG0006	proline dipeptidase activity
B224_RS20150	COG1739	Uncharacterized protein family UPF0029
B224_RS20155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B224_RS20160	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
B224_RS20190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B224_RS20195	COG2166	iron-sulfur cluster assembly
B224_RS20200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B224_RS20205	COG0210	DNA helicase
B224_RS20220	COG1063	alcohol dehydrogenase
B224_RS20235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B224_RS20240	COG0438	transferase activity, transferring glycosyl groups
B224_RS20245	COG3307	-O-antigen
B224_RS20255	COG5433	transposase activity
B224_RS20265	COG0604	alcohol dehydrogenase
B224_RS20275	COG1580	Controls the rotational direction of flagella during chemotaxis
B224_RS20280	COG3161	chorismate lyase activity
B224_RS20285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B224_RS20290	COG2937	Belongs to the GPAT DAPAT family
B224_RS20295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B224_RS20310	COG0534	Mate efflux family protein
B224_RS20315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B224_RS20320	COG2205	protein histidine kinase activity
B224_RS20325	COG0745	RESPONSE REGULATOR receiver
B224_RS20335	COG1045	serine acetyltransferase
B224_RS20345	COG3074	FtsZ-dependent cytokinesis
B224_RS20350	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
B224_RS20355	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B224_RS20355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B224_RS20360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B224_RS20405	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
B224_RS20415	COG3706	GGDEF domain
B224_RS20420	COG0513	Belongs to the DEAD box helicase family
B224_RS20475	COG0154	amidase activity
B224_RS20480	COG2957	Belongs to the agmatine deiminase family
B224_RS20500	COG1902	pentaerythritol trinitrate reductase activity
B224_RS20510	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B224_RS20520	COG3300	MHYT domain
B224_RS20520	COG5001	Diguanylate cyclase
B224_RS20525	COG2425	protein containing a von Willebrand factor type A (vWA) domain
B224_RS20540	COG0456	acetyltransferase
B224_RS20550	COG1022	Amp-dependent synthetase and ligase
B224_RS20560	COG1794	racemase activity, acting on amino acids and derivatives
B224_RS20575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B224_RS20590	COG0733	neurotransmitter:sodium symporter activity
B224_RS20595	COG0733	neurotransmitter:sodium symporter activity
B224_RS20610	COG0561	phosphatase activity
B224_RS20640	COG1846	Transcriptional regulator
B224_RS20645	COG2130	NADP-dependent
B224_RS20670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B224_RS20675	COG1640	4-alpha-glucanotransferase
B224_RS20680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B224_RS20690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B224_RS20765	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B224_RS20770	COG2885	chlorophyll binding
B224_RS20775	COG0823	Involved in the tonB-independent uptake of proteins
B224_RS20790	COG0811	peptide transport
B224_RS20795	COG0824	Thioesterase
B224_RS20800	COG3790	cyd operon protein YbgE
B224_RS20810	COG1294	oxidase, subunit
B224_RS20815	COG1271	oxidase subunit
B224_RS20820	COG2255	four-way junction helicase activity
B224_RS20825	COG0632	four-way junction helicase activity
B224_RS20830	COG0442	prolyl-tRNA aminoacylation
B224_RS20835	COG4221	oxidoreductase activity
B224_RS20850	COG1024	Enoyl-CoA hydratase
B224_RS20865	COG4166	transmembrane transport
B224_RS20875	COG0840	transmembrane signaling receptor activity
B224_RS20895	COG0513	Belongs to the DEAD box helicase family
B224_RS20915	COG3385	transposase activity
B224_RS20935	COG0457	Tetratricopeptide repeat
B224_RS20935	COG3118	belongs to the thioredoxin family
B224_RS20945	COG1215	transferase activity, transferring glycosyl groups
B224_RS20975	COG1448	Aminotransferase
B224_RS20990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B224_RS20995	COG1328	CTP reductase activity
B224_RS21025	COG0840	transmembrane signaling receptor activity
B224_RS21030	COG3397	chitin binding
B224_RS21040	COG0583	DNA-binding transcription factor activity
B224_RS21045	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B224_RS21050	COG4208	sulfate ABC transporter
B224_RS21055	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B224_RS21105	COG1396	sequence-specific DNA binding
B224_RS21110	COG3135	benzoate transporter
B224_RS21120	COG1522	sequence-specific DNA binding
B224_RS21130	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B224_RS21140	COG1058	Belongs to the CinA family
B224_RS21140	COG1546	Belongs to the CinA family
B224_RS21145	COG1988	membrane-bound metal-dependent
B224_RS21155	COG0561	phosphatase activity
B224_RS21160	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B224_RS21175	COG1011	Hydrolase
B224_RS21190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B224_RS21195	COG0019	diaminopimelate decarboxylase activity
B224_RS21205	COG1965	Belongs to the frataxin family
B224_RS21210	COG0400	carboxylic ester hydrolase activity
B224_RS21215	COG3072	Adenylate cyclase
B224_RS21220	COG0181	hydroxymethylbilane synthase activity
B224_RS21230	COG2959	enzyme of heme biosynthesis
B224_RS21235	COG3071	HemY protein
B224_RS21250	COG1494	fructose-1,6-bisphosphatase
B224_RS21260	COG1247	-acetyltransferase
B224_RS21280	COG1733	regulation of RNA biosynthetic process
B224_RS21295	COG3932	Exopolysaccharide synthesis, ExoD
B224_RS21325	COG3039	Transposase
B224_RS21330	COG3039	Transposase
B224_RS21335	COG3385	transposase activity
B224_RS21340	COG3385	transposase activity
B224_RS21345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B224_RS21350	COG2022	thiamine diphosphate biosynthetic process
B224_RS21360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B224_RS21365	COG0352	thiamine-phosphate diphosphorylase activity
B224_RS21370	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B224_RS21380	COG3385	transposase activity
B224_RS21390	COG5433	transposase activity
B224_RS21415	COG0745	RESPONSE REGULATOR receiver
B224_RS21425	COG0189	ligase activity
B224_RS21455	COG3039	Transposase
B224_RS21470	COG5433	transposase activity
B224_RS21480	COG3039	Transposase
B224_RS21485	COG1484	DNA-dependent DNA replication
B224_RS21505	COG2321	neutral zinc metallopeptidase
B224_RS21510	COG3385	transposase activity
B224_RS21515	COG2321	neutral zinc metallopeptidase
B224_RS21525	COG0477	Major facilitator Superfamily
B224_RS21545	COG0312	modulator of DNA gyrase
B224_RS21550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B224_RS21555	COG3164	Protein of unknown function
B224_RS21560	COG1530	ribonuclease E activity
B224_RS21565	COG0424	maF-like protein
B224_RS21570	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B224_RS21575	COG1792	Involved in formation and maintenance of cell shape
B224_RS21580	COG1077	Cell shape determining protein MreB Mrl
B224_RS21590	COG5433	transposase activity
B224_RS21625	COG2200	EAL domain
B224_RS21625	COG2199	diguanylate cyclase activity
B224_RS21630	COG3039	Transposase
B224_RS21635	COG2200	EAL domain
B224_RS21640	COG0387	Pfam Sodium calcium exchanger
B224_RS21645	COG2986	histidine ammonia-lyase
B224_RS21650	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B224_RS21655	COG0010	Belongs to the arginase family
B224_RS21660	COG1228	amidohydrolase
B224_RS21670	COG2188	Transcriptional regulator
B224_RS21675	COG0288	reversible hydration of carbon dioxide
B224_RS21685	COG2177	Part of the ABC transporter FtsEX involved in
B224_RS21690	COG2884	Cell division ATP-binding protein ftsE
B224_RS21695	COG0552	protein localization to endoplasmic reticulum
B224_RS21835	COG2916	Histone family protein nucleoid-structuring protein H-NS
B224_RS21885	COG5433	transposase activity