locus-tag	class	description
CE463_RS00040	COG2974	May be involved in recombination
CE463_RS00080	COG1525	nuclease
CE463_RS00110	COG1192	Involved in chromosome partitioning
CE463_RS00165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CE463_RS00170	COG1061	Type III restriction enzyme res subunit
CE463_RS00175	COG1002	Type II restriction enzyme, methylase subunits
CE463_RS00190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CE463_RS00330	COG0714	Associated with various cellular activities
CE463_RS00395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CE463_RS00470	COG3409	Peptidoglycan-binding domain 1 protein
CE463_RS00470	COG3267	Type II secretory pathway component ExeA
CE463_RS00530	COG0778	Nitroreductase
CE463_RS00535	COG0583	DNA-binding transcription factor activity
CE463_RS00645	COG1396	sequence-specific DNA binding
CE463_RS00650	COG3550	peptidyl-serine autophosphorylation
CE463_RS00670	COG1660	Displays ATPase and GTPase activities
CE463_RS00725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE463_RS00735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE463_RS00780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CE463_RS00815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE463_RS00850	COG0456	acetyltransferase
CE463_RS00855	COG3039	Transposase
CE463_RS00870	COG1357	PFAM Pentapeptide repeats (8 copies)
CE463_RS00905	COG4644	lycopene metabolic process
CE463_RS00970	COG1695	Transcriptional regulator
CE463_RS01000	COG3173	Aminoglycoside phosphotransferase
CE463_RS01185	COG1192	Involved in chromosome partitioning
CE463_RS01205	COG2361	Protein of unknown function DUF86
CE463_RS01210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE463_RS01360	COG3039	Transposase
CE463_RS01410	COG2003	Belongs to the UPF0758 family
CE463_RS01465	COG1192	Involved in chromosome partitioning
CE463_RS01485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CE463_RS01510	COG2916	Histone family protein nucleoid-structuring protein H-NS
CE463_RS01520	COG1192	Involved in chromosome partitioning
CE463_RS01530	COG3328	transposase activity
CE463_RS01560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CE463_RS01565	COG1317	bacterial-type flagellum organization
CE463_RS01655	COG0457	Tetratricopeptide repeat
CE463_RS01725	COG4790	Type iii secretion
CE463_RS01730	COG4794	Type iii secretion
CE463_RS01735	COG4791	protein targeting
CE463_RS01740	COG4792	protein secretion
CE463_RS01750	COG2826	transposase and inactivated derivatives, IS30 family
CE463_RS01795	COG1484	DNA-dependent DNA replication
CE463_RS01905	COG1192	Involved in chromosome partitioning
CE463_RS01930	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CE463_RS01935	COG2361	Protein of unknown function DUF86
CE463_RS02015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CE463_RS02020	COG0592	DNA-directed DNA polymerase activity
CE463_RS02045	COG2378	regulation of single-species biofilm formation
CE463_RS02050	COG0071	Belongs to the small heat shock protein (HSP20) family
CE463_RS02055	COG0071	Belongs to the small heat shock protein (HSP20) family
CE463_RS02070	COG3977	Valine--pyruvate aminotransferase
CE463_RS02085	COG2814	Major facilitator Superfamily
CE463_RS02090	COG0745	RESPONSE REGULATOR receiver
CE463_RS02095	COG2205	protein histidine kinase activity
CE463_RS02120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CE463_RS02125	COG4191	Histidine kinase
CE463_RS02125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE463_RS02130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE463_RS02135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE463_RS02140	COG1309	transcriptional regulator
CE463_RS02170	COG0561	phosphatase activity
CE463_RS02175	COG2267	carboxylic ester hydrolase activity
CE463_RS02180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CE463_RS02185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CE463_RS02190	COG1758	RNA polymerase activity
CE463_RS02195	COG0194	GDP metabolic process
CE463_RS02205	COG0859	PFAM glycosyl transferase family 9
CE463_RS02210	COG3642	lipopolysaccharide core region biosynthetic process
CE463_RS02250	COG0589	response to stress
CE463_RS02255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CE463_RS02265	COG1528	Iron-storage protein
CE463_RS02270	COG2081	HI0933 family
CE463_RS02295	COG5433	transposase activity
CE463_RS02305	COG5433	transposase activity
CE463_RS02310	COG2205	protein histidine kinase activity
CE463_RS02310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE463_RS02320	COG2205	protein histidine kinase activity
CE463_RS02320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE463_RS02330	COG3275	phosphorelay sensor kinase activity
CE463_RS02335	COG3279	Response regulator of the LytR AlgR family
CE463_RS02340	COG2223	nitrite transmembrane transporter activity
CE463_RS02345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CE463_RS02350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CE463_RS02365	COG0583	DNA-binding transcription factor activity
CE463_RS02370	COG4206	TonB-dependent receptor
CE463_RS02375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CE463_RS02420	COG0583	DNA-binding transcription factor activity
CE463_RS02425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CE463_RS02430	COG0166	Belongs to the GPI family
CE463_RS02440	COG0668	transmembrane transport
CE463_RS02445	COG1309	transcriptional regulator
CE463_RS02450	COG0756	dUTP diphosphatase activity
CE463_RS02455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CE463_RS02460	COG2003	Belongs to the UPF0758 family
CE463_RS02465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CE463_RS02470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CE463_RS02480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CE463_RS02485	COG2990	Protein conserved in bacteria
CE463_RS02490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CE463_RS02495	COG0859	PFAM glycosyl transferase family 9
CE463_RS02500	COG0463	Glycosyl transferase, family 2
CE463_RS02505	COG0859	PFAM glycosyl transferase family 9
CE463_RS02510	COG1519	Transferase
CE463_RS02525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE463_RS02530	COG1609	Transcriptional regulator
CE463_RS02535	COG0604	alcohol dehydrogenase
CE463_RS02560	COG1580	Controls the rotational direction of flagella during chemotaxis
CE463_RS02565	COG3161	chorismate lyase activity
CE463_RS02570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CE463_RS02575	COG2937	Belongs to the GPAT DAPAT family
CE463_RS02580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CE463_RS02595	COG0534	Mate efflux family protein
CE463_RS02600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CE463_RS02605	COG2205	protein histidine kinase activity
CE463_RS02610	COG0745	RESPONSE REGULATOR receiver
CE463_RS02620	COG1045	serine acetyltransferase
CE463_RS02630	COG3074	FtsZ-dependent cytokinesis
CE463_RS02635	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CE463_RS02650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CE463_RS02700	COG1609	Transcriptional regulator
CE463_RS02705	COG0385	Bile acid
CE463_RS02710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CE463_RS02730	COG0583	DNA-binding transcription factor activity
CE463_RS02735	COG1079	Belongs to the binding-protein-dependent transport system permease family
CE463_RS02740	COG4603	Belongs to the binding-protein-dependent transport system permease family
CE463_RS02745	COG3845	ABC transporter
CE463_RS02750	COG1744	ABC transporter substrate-binding protein PnrA-like
CE463_RS02755	COG0210	DNA helicase
CE463_RS02790	COG1280	lysine exporter protein (LysE YggA)
CE463_RS02795	COG2391	methyltransferase activity
CE463_RS02800	COG5433	transposase activity
CE463_RS02810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CE463_RS02825	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CE463_RS02830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CE463_RS02840	COG0018	arginyl-trna synthetase
CE463_RS02850	COG1595	DNA-templated transcription, initiation
CE463_RS02860	COG1968	undecaprenyl-diphosphatase activity
CE463_RS02865	COG0667	Aldo Keto reductase
CE463_RS02870	COG2017	converts alpha-aldose to the beta-anomer
CE463_RS02875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CE463_RS02885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE463_RS02890	COG1609	Transcriptional regulator
CE463_RS02895	COG3250	beta-galactosidase activity
CE463_RS02910	COG4211	Belongs to the binding-protein-dependent transport system permease family
CE463_RS02920	COG3328	transposase activity
CE463_RS02950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CE463_RS02955	COG1288	antiporter activity
CE463_RS02960	COG1438	arginine binding
CE463_RS02965	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CE463_RS02970	COG0540	Belongs to the ATCase OTCase family
CE463_RS02985	COG0688	phosphatidylethanolamine metabolic process
CE463_RS02995	COG3040	lipid binding
CE463_RS03005	COG1979	alcohol dehydrogenase
CE463_RS03010	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CE463_RS03015	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CE463_RS03025	COG2964	Protein conserved in bacteria
CE463_RS03030	COG3681	Belongs to the UPF0597 family
CE463_RS03040	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE463_RS03045	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CE463_RS03050	COG0564	pseudouridine synthase activity
CE463_RS03060	COG0542	response to heat
CE463_RS03065	COG2502	aspartate--ammonia ligase
CE463_RS03070	COG1522	sequence-specific DNA binding
CE463_RS03080	COG5413	integral membrane protein
CE463_RS03085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CE463_RS03085	COG0517	IMP dehydrogenase activity
CE463_RS03085	COG0617	tRNA 3'-terminal CCA addition
CE463_RS03090	COG1028	Short-chain dehydrogenase reductase Sdr
CE463_RS03100	COG2205	protein histidine kinase activity
CE463_RS03110	COG2204	response regulator
CE463_RS03125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CE463_RS03130	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CE463_RS03160	COG0243	molybdopterin cofactor binding
CE463_RS03165	COG3005	denitrification pathway
CE463_RS03170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CE463_RS03175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CE463_RS03180	COG0569	domain protein
CE463_RS03185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CE463_RS03210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CE463_RS03225	COG0250	Participates in transcription elongation, termination and antitermination
CE463_RS03230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CE463_RS03235	COG0081	regulation of translation
CE463_RS03240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CE463_RS03245	COG0222	ribosome binding
CE463_RS03250	COG0085	RNA polymerase activity
CE463_RS03255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CE463_RS03260	COG2964	Protein conserved in bacteria
CE463_RS03275	COG2923	Belongs to the DsrF TusC family
CE463_RS03280	COG2168	tRNA wobble position uridine thiolation
CE463_RS03285	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CE463_RS03290	COG0049	tRNA binding
CE463_RS03295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CE463_RS03300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CE463_RS03305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CE463_RS03365	COG3047	cAMP biosynthetic process
CE463_RS03395	COG3135	benzoate transporter
CE463_RS03400	COG1396	sequence-specific DNA binding
CE463_RS03440	COG2252	PERMEase
CE463_RS03445	COG2376	Dihydroxyacetone kinase
CE463_RS03450	COG1461	Dihydroxyacetone kinase
CE463_RS03455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE463_RS03455	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CE463_RS03455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CE463_RS03465	COG3284	Transcriptional regulator
CE463_RS03470	COG0628	permease
CE463_RS03475	COG0494	nUDIX hydrolase
CE463_RS03500	COG0753	catalase activity
CE463_RS03505	COG1247	-acetyltransferase
CE463_RS03525	COG2203	Gaf domain
CE463_RS03525	COG2199	diguanylate cyclase activity
CE463_RS03535	COG3842	ATPase activity
CE463_RS03545	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE463_RS03570	COG0583	DNA-binding transcription factor activity
CE463_RS03580	COG1741	Belongs to the pirin family
CE463_RS03585	COG2259	Doxx family
CE463_RS03590	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CE463_RS03595	COG1074	ATP-dependent DNA helicase activity
CE463_RS03600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CE463_RS03620	COG0346	lactoylglutathione lyase activity
CE463_RS03630	COG5433	transposase activity
CE463_RS03645	COG0004	ammonium transporteR
CE463_RS03650	COG0347	Belongs to the P(II) protein family
CE463_RS03665	COG0840	transmembrane signaling receptor activity
CE463_RS03675	COG3706	GGDEF domain
CE463_RS03685	COG1278	Cold shock
CE463_RS03690	COG2199	diguanylate cyclase activity
CE463_RS03695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CE463_RS03700	COG2197	response regulator
CE463_RS03755	COG1677	Flagellar hook-basal body complex protein FliE
CE463_RS03765	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CE463_RS03790	COG2747	anti-sigma28 factor FlgM
CE463_RS03800	COG1815	bacterial-type flagellum-dependent cell motility
CE463_RS03810	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CE463_RS03815	COG1749	Flagellar hook protein flgE
CE463_RS03820	COG4786	Flagellar basal body rod
CE463_RS03825	COG4786	Flagellar basal body rod
CE463_RS03830	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CE463_RS03835	COG1706	bacterial-type flagellum-dependent cell motility
CE463_RS03845	COG4786	Flagellar basal body rod
CE463_RS03845	COG1256	bacterial-type flagellum assembly
CE463_RS03865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CE463_RS03875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CE463_RS03880	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CE463_RS03905	COG1191	sigma factor activity
CE463_RS03910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CE463_RS03915	COG1360	Flagellar Motor Protein
CE463_RS03925	COG0741	lytic transglycosylase activity
CE463_RS03925	COG1388	LysM domain
CE463_RS03935	COG2001	Belongs to the MraZ family
CE463_RS03940	COG0275	rRNA processing
CE463_RS03945	COG3116	cell division
CE463_RS03950	COG0768	penicillin binding
CE463_RS03960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CE463_RS03965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CE463_RS03970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CE463_RS03975	COG0772	Belongs to the SEDS family
CE463_RS03980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CE463_RS03985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CE463_RS03990	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CE463_RS03995	COG0849	cell division
CE463_RS04000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CE463_RS04005	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CE463_RS04015	COG0653	protein targeting
CE463_RS04025	COG0494	nUDIX hydrolase
CE463_RS04030	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CE463_RS04035	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CE463_RS04045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CE463_RS04055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CE463_RS04090	COG2186	Transcriptional regulator
CE463_RS04095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CE463_RS04100	COG0508	dehydrogenase complex catalyzes the overall conversion of
CE463_RS04105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CE463_RS04110	COG3447	MASE1 domain protein
CE463_RS04110	COG5001	Diguanylate cyclase
CE463_RS04110	COG5002	protein histidine kinase activity
CE463_RS04120	COG0840	transmembrane signaling receptor activity
CE463_RS04125	COG0840	transmembrane signaling receptor activity
CE463_RS04135	COG1049	propionate catabolic process, 2-methylcitrate cycle
CE463_RS04140	COG2200	EAL domain
CE463_RS04145	COG1028	Short-chain dehydrogenase reductase Sdr
CE463_RS04150	COG0583	DNA-binding transcription factor activity
CE463_RS04160	COG1280	lysine exporter protein (LysE YggA)
CE463_RS04170	COG0523	cobalamin synthesis protein
CE463_RS04190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CE463_RS04195	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CE463_RS04325	COG3314	Sporulation integral membrane protein YlbJ
CE463_RS04335	COG0835	chemotaxis
CE463_RS04335	COG0784	Response regulator, receiver
CE463_RS04340	COG1028	Short-chain dehydrogenase reductase Sdr
CE463_RS04345	COG1444	tRNA N-acetyltransferase activity
CE463_RS04370	COG1803	Methylglyoxal synthase
CE463_RS04385	COG0252	asparaginase activity
CE463_RS04395	COG1609	Transcriptional regulator
CE463_RS04405	COG1940	carbohydrate kinase activity
CE463_RS04410	COG1447	Phosphotransferase system cellobiose-specific component IIA
CE463_RS04415	COG2723	6-phospho-beta-galactosidase activity
CE463_RS04425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CE463_RS04430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CE463_RS04445	COG1263	PTS System
CE463_RS04445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE463_RS04450	COG0366	Alpha amylase catalytic
CE463_RS04455	COG0110	maltose O-acetyltransferase activity
CE463_RS04465	COG1757	Na H antiporter
CE463_RS04500	COG0297	glycogen (starch) synthase activity
CE463_RS04505	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CE463_RS04510	COG2813	Specifically methylates the guanine in position
CE463_RS04515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CE463_RS04530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE463_RS04540	COG2995	paraquat-inducible protein a
CE463_RS04545	COG3008	intermembrane lipid transfer
CE463_RS04545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CE463_RS04550	COG3009	Protein conserved in bacteria
CE463_RS04565	COG3240	lipase activity
CE463_RS04570	COG3111	PFAM Bacterial OB fold (BOF) protein
CE463_RS04580	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CE463_RS04585	COG1194	a g-specific adenine glycosylase
CE463_RS04595	COG3409	Peptidoglycan-binding domain 1 protein
CE463_RS04595	COG3267	Type II secretory pathway component ExeA
CE463_RS04600	COG0617	tRNA 3'-terminal CCA addition
CE463_RS04605	COG0306	phosphate transporter
CE463_RS04610	COG1392	Phosphate transport regulator
CE463_RS04625	COG1560	Kdo2-lipid A biosynthetic process
CE463_RS04630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CE463_RS04630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CE463_RS04635	COG1538	Outer membrane efflux protein
CE463_RS04640	COG0494	nUDIX hydrolase
CE463_RS04645	COG3151	Protein conserved in bacteria
CE463_RS04655	COG3150	esterase
CE463_RS04660	COG1051	belongs to the nudix hydrolase family
CE463_RS04740	COG2259	Doxx family
CE463_RS04745	COG3118	belongs to the thioredoxin family
CE463_RS04765	COG0204	Acyl-transferase
CE463_RS04785	COG2827	Endonuclease containing a URI domain
CE463_RS04800	COG1573	uracil-dna glycosylase
CE463_RS04810	COG0583	DNA-binding transcription factor activity
CE463_RS04815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CE463_RS04820	COG1121	(ABC) transporter
CE463_RS04825	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CE463_RS04845	COG0739	heme binding
CE463_RS04855	COG3068	Protein conserved in bacteria
CE463_RS04875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CE463_RS04895	COG0798	PFAM Bile acid sodium symporter
CE463_RS04900	COG1393	Belongs to the ArsC family
CE463_RS04910	COG2072	flavoprotein involved in K transport
CE463_RS04920	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CE463_RS04930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CE463_RS04935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CE463_RS04945	COG0137	argininosuccinate synthase activity
CE463_RS04950	COG0165	Argininosuccinate lyase
CE463_RS04955	COG0583	DNA-binding transcription factor activity
CE463_RS04965	COG1942	4-Oxalocrotonate Tautomerase
CE463_RS04995	COG0110	maltose O-acetyltransferase activity
CE463_RS05000	COG3174	membrane
CE463_RS05005	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CE463_RS05015	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CE463_RS05025	COG4208	sulfate ABC transporter
CE463_RS05030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CE463_RS05035	COG0583	DNA-binding transcription factor activity
CE463_RS05040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CE463_RS05045	COG0765	amino acid transport
CE463_RS05055	COG1126	abc transporter atp-binding protein
CE463_RS05060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE463_RS05065	COG3397	chitin binding
CE463_RS05105	COG0726	polysaccharide deacetylase
CE463_RS05105	COG1649	PFAM Uncharacterised BCR, COG1649
CE463_RS05110	COG1215	transferase activity, transferring glycosyl groups
CE463_RS05155	COG1328	CTP reductase activity
CE463_RS05160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CE463_RS05180	COG1448	Aminotransferase
CE463_RS05220	COG0513	Belongs to the DEAD box helicase family
CE463_RS05235	COG3568	Endonuclease Exonuclease Phosphatase
CE463_RS05240	COG0840	transmembrane signaling receptor activity
CE463_RS05255	COG3112	Uncharacterised protein family (UPF0231)
CE463_RS05260	COG3835	regulator
CE463_RS05265	COG2610	gluconate transmembrane transporter activity
CE463_RS05270	COG1929	Belongs to the glycerate kinase type-1 family
CE463_RS05290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CE463_RS05305	COG0347	Belongs to the P(II) protein family
CE463_RS05310	COG1840	ABC-type Fe3 transport system, periplasmic component
CE463_RS05320	COG3842	ATPase activity
CE463_RS05325	COG2837	iron assimilation
CE463_RS05330	COG1438	arginine binding
CE463_RS05335	COG1126	abc transporter atp-binding protein
CE463_RS05340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE463_RS05345	COG4215	(ABC) transporter
CE463_RS05350	COG4160	amino acid transport
CE463_RS05355	COG0039	L-malate dehydrogenase activity
CE463_RS05360	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CE463_RS05365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CE463_RS05365	COG1017	nitric oxide dioxygenase activity
CE463_RS05370	COG1959	2 iron, 2 sulfur cluster binding
CE463_RS05375	COG4536	flavin adenine dinucleotide binding
CE463_RS05380	COG4137	Cytochrome C assembly protein
CE463_RS05385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CE463_RS05390	COG0228	four-way junction DNA binding
CE463_RS05395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CE463_RS05400	COG0336	Belongs to the RNA methyltransferase TrmD family
CE463_RS05405	COG0335	large ribosomal subunit rRNA binding
CE463_RS05415	COG3066	DNA modification
CE463_RS05420	COG1051	belongs to the nudix hydrolase family
CE463_RS05430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CE463_RS05435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CE463_RS05440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE463_RS05450	COG0583	DNA-binding transcription factor activity
CE463_RS05455	COG0640	Transcriptional regulator
CE463_RS05460	COG0268	Binds directly to 16S ribosomal RNA
CE463_RS05465	COG0728	peptidoglycan biosynthetic process
CE463_RS05470	COG0196	riboflavin kinase activity
CE463_RS05475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CE463_RS05480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CE463_RS05485	COG1047	Peptidyl-prolyl cis-trans
CE463_RS05490	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CE463_RS05530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CE463_RS05530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CE463_RS05545	COG1854	S-ribosylhomocysteine lyase activity
CE463_RS05550	COG3706	GGDEF domain
CE463_RS05555	COG0557	exoribonuclease II activity
CE463_RS05560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CE463_RS05570	COG2153	protein acetylation
CE463_RS05590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CE463_RS05595	COG1914	H( )-stimulated, divalent metal cation uptake system
CE463_RS05600	COG0360	Binds together with S18 to 16S ribosomal RNA
CE463_RS05605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CE463_RS05610	COG0359	binds to the 23S rRNA
CE463_RS05640	COG1064	alcohol dehydrogenase
CE463_RS05645	COG1238	metal cluster binding
CE463_RS05650	COG0612	Peptidase, M16
CE463_RS05655	COG2918	glutathione biosynthetic process
CE463_RS05665	COG1022	Amp-dependent synthetase and ligase
CE463_RS05675	COG0456	acetyltransferase
CE463_RS05685	COG0714	Associated with various cellular activities
CE463_RS05715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CE463_RS05725	COG1902	pentaerythritol trinitrate reductase activity
CE463_RS05735	COG0442	prolyl-tRNA aminoacylation
CE463_RS05745	COG0632	four-way junction helicase activity
CE463_RS05750	COG2255	four-way junction helicase activity
CE463_RS05755	COG1271	oxidase subunit
CE463_RS05760	COG1294	oxidase, subunit
CE463_RS05765	COG4890	Cyd operon protein YbgT
CE463_RS05770	COG3790	cyd operon protein YbgE
CE463_RS05775	COG0824	Thioesterase
CE463_RS05780	COG0811	peptide transport
CE463_RS05795	COG0823	Involved in the tonB-independent uptake of proteins
CE463_RS05800	COG2885	chlorophyll binding
CE463_RS05805	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CE463_RS05870	COG0840	transmembrane signaling receptor activity
CE463_RS05875	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CE463_RS05880	COG0676	glucose-6-phosphate 1-epimerase activity
CE463_RS05885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CE463_RS05890	COG1640	4-alpha-glucanotransferase
CE463_RS05895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CE463_RS05915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CE463_RS05920	COG4991	sh3 domain protein
CE463_RS05925	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CE463_RS05925	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CE463_RS05925	COG0506	proline dehydrogenase activity
CE463_RS05935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CE463_RS05940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CE463_RS05945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CE463_RS05950	COG0163	prenyltransferase activity
CE463_RS05965	COG1131	(ABC) transporter
CE463_RS05970	COG0842	Transport permease protein
CE463_RS05980	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CE463_RS05985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CE463_RS05990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CE463_RS05995	COG0617	tRNA 3'-terminal CCA addition
CE463_RS06000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE463_RS06005	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CE463_RS06010	COG1489	DNA binding
CE463_RS06020	COG1643	Atp-dependent helicase
CE463_RS06025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CE463_RS06030	COG0346	lactoylglutathione lyase activity
CE463_RS06040	COG2076	Multidrug Resistance protein
CE463_RS06045	COG0583	DNA-binding transcription factor activity
CE463_RS06050	COG3437	response regulator, receiver
CE463_RS06050	COG0784	Response regulator, receiver
CE463_RS06060	COG0671	phosphoesterase, PA-phosphatase related
CE463_RS06075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CE463_RS06080	COG0038	chloride channel
CE463_RS06090	COG0316	Belongs to the HesB IscA family
CE463_RS06120	COG2816	NAD+ diphosphatase activity
CE463_RS06125	COG2205	protein histidine kinase activity
CE463_RS06130	COG0745	RESPONSE REGULATOR receiver
CE463_RS06135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE463_RS06150	COG1505	serine-type exopeptidase activity
CE463_RS06155	COG2982	Protein involved in outer membrane biogenesis
CE463_RS06165	COG1028	Short-chain dehydrogenase reductase Sdr
CE463_RS06200	COG1349	DNA-binding transcription factor activity
CE463_RS06205	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CE463_RS06225	COG2130	NADP-dependent
CE463_RS06230	COG1764	response to oxidative stress
CE463_RS06235	COG1846	Transcriptional regulator
CE463_RS06265	COG0561	phosphatase activity
CE463_RS06280	COG0733	neurotransmitter:sodium symporter activity
CE463_RS06290	COG0733	neurotransmitter:sodium symporter activity
CE463_RS06315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE463_RS06330	COG1794	racemase activity, acting on amino acids and derivatives
CE463_RS06340	COG2731	YhcH YjgK YiaL family protein
CE463_RS06350	COG0668	transmembrane transport
CE463_RS06355	COG1376	ErfK ybiS ycfS ynhG family protein
CE463_RS06360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CE463_RS06395	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CE463_RS06405	COG0488	(ABC) transporter
CE463_RS06410	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CE463_RS06410	COG0517	IMP dehydrogenase activity
CE463_RS06415	COG1585	Membrane protein implicated in regulation of membrane protease activity
CE463_RS06420	COG0330	HflC and HflK could
CE463_RS06425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CE463_RS06425	COG1648	precorrin-2 dehydrogenase activity
CE463_RS06430	COG0175	sulfate reduction
CE463_RS06435	COG2895	sulfate adenylyltransferase (ATP) activity
CE463_RS06440	COG3273	potassium ion transport
CE463_RS06440	COG0471	metal ion transport
CE463_RS06445	COG0529	Catalyzes the synthesis of activated sulfate
CE463_RS06450	COG5433	transposase activity
CE463_RS06460	COG3328	transposase activity
CE463_RS06500	COG1136	(ABC) transporter
CE463_RS06515	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CE463_RS06540	COG1940	carbohydrate kinase activity
CE463_RS06545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CE463_RS06550	COG0126	phosphoglycerate kinase activity
CE463_RS06555	COG0191	fructose-bisphosphate aldolase activity
CE463_RS06560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE463_RS06610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CE463_RS06615	COG1595	DNA-templated transcription, initiation
CE463_RS06620	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CE463_RS06635	COG0481	GTPase activity
CE463_RS06645	COG0571	ribonuclease III activity
CE463_RS06655	COG1381	Involved in DNA repair and RecF pathway recombination
CE463_RS06660	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CE463_RS06665	COG3023	N-Acetylmuramoyl-L-alanine amidase
CE463_RS06670	COG4807	Protein conserved in bacteria
CE463_RS06680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CE463_RS06685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CE463_RS06690	COG3956	TIGRFAM MazG family protein
CE463_RS06695	COG0504	CTP synthase activity
CE463_RS06700	COG0148	phosphopyruvate hydratase activity
CE463_RS06705	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CE463_RS06710	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CE463_RS06720	COG0585	pseudouridine synthase activity
CE463_RS06725	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CE463_RS06730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CE463_RS06735	COG1238	metal cluster binding
CE463_RS06740	COG4942	peptidase
CE463_RS06740	COG1388	LysM domain
CE463_RS06750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CE463_RS06755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CE463_RS06760	COG1610	YqeY-like protein
CE463_RS06765	COG0358	DNA primase activity
CE463_RS06770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CE463_RS06810	COG0151	Belongs to the GarS family
CE463_RS06815	COG0138	bifunctional purine biosynthesis protein purh
CE463_RS06825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CE463_RS06830	COG3036	rescue of stalled ribosome
CE463_RS06835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CE463_RS06840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CE463_RS06850	COG0673	inositol 2-dehydrogenase activity
CE463_RS06860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE463_RS06865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE463_RS06870	COG3227	Zinc metalloprotease (Elastase)
CE463_RS06880	COG0477	Major facilitator Superfamily
CE463_RS06890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CE463_RS06895	COG1027	Aspartate ammonia-lyase
CE463_RS06900	COG3030	protein affecting phage T7 exclusion by the F plasmid
CE463_RS06905	COG0534	Mate efflux family protein
CE463_RS06910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CE463_RS06915	COG0459	protein refolding
CE463_RS06925	COG3300	MHYT domain
CE463_RS06925	COG5001	Diguanylate cyclase
CE463_RS06935	COG0564	pseudouridine synthase activity
CE463_RS06940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CE463_RS06970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CE463_RS06980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CE463_RS06985	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CE463_RS06990	COG1178	ABC-type Fe3 transport system permease component
CE463_RS06995	COG4143	(ABC) transporter
CE463_RS07010	COG0066	3-isopropylmalate dehydratase activity
CE463_RS07015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CE463_RS07020	COG0473	3-isopropylmalate dehydrogenase activity
CE463_RS07025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CE463_RS07035	COG0671	phosphoesterase, PA-phosphatase related
CE463_RS07050	COG0028	Belongs to the TPP enzyme family
CE463_RS07055	COG0440	acetolactate synthase activity
CE463_RS07060	COG0857	belongs to the CobB CobQ family
CE463_RS07060	COG0280	phosphate acetyltransferase
CE463_RS07065	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CE463_RS07075	COG3013	Belongs to the UPF0304 family
CE463_RS07080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CE463_RS07085	COG2716	regulation of RNA biosynthetic process
CE463_RS07095	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CE463_RS07100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CE463_RS07135	COG5002	protein histidine kinase activity
CE463_RS07135	COG0784	Response regulator, receiver
CE463_RS07135	COG2198	Histidine kinase
CE463_RS07160	COG0840	transmembrane signaling receptor activity
CE463_RS07170	COG1464	Belongs to the NlpA lipoprotein family
CE463_RS07175	COG2011	ABC-type metal ion transport system permease component
CE463_RS07180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CE463_RS07200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CE463_RS07200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CE463_RS07205	COG0802	atpase or kinase
CE463_RS07215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CE463_RS07220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CE463_RS07225	COG1923	regulation of RNA biosynthetic process
CE463_RS07230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CE463_RS07235	COG0330	HflC and HflK could
CE463_RS07240	COG0330	HflC and HflK could
CE463_RS07245	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CE463_RS07250	COG0142	geranyltranstransferase activity
CE463_RS07255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CE463_RS07260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CE463_RS07265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CE463_RS07270	COG3314	Sporulation integral membrane protein YlbJ
CE463_RS07275	COG0318	PFAM AMP-dependent synthetase and ligase
CE463_RS07295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CE463_RS07310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CE463_RS07315	COG2967	ApaG domain
CE463_RS07320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CE463_RS07325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CE463_RS07335	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CE463_RS07340	COG3178	'Phosphotransferase
CE463_RS07345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CE463_RS07350	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CE463_RS07355	COG2252	PERMEase
CE463_RS07365	COG0488	(ABC) transporter
CE463_RS07390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE463_RS07400	COG3721	Heme iron utilization protein
CE463_RS07405	COG0748	coenzyme F420 binding
CE463_RS07425	COG4771	TonB-dependent receptor
CE463_RS07430	COG2814	Major facilitator Superfamily
CE463_RS07440	COG3655	Transcriptional regulator
CE463_RS07460	COG2202	Pas domain
CE463_RS07460	COG2205	protein histidine kinase activity
CE463_RS07475	COG3397	chitin binding
CE463_RS07490	COG1765	OsmC-like protein
CE463_RS07505	COG3954	Phosphoribulokinase
CE463_RS07510	COG2076	Multidrug Resistance protein
CE463_RS07515	COG2076	Multidrug Resistance protein
CE463_RS07520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CE463_RS07525	COG0726	polysaccharide deacetylase
CE463_RS07535	COG0463	Glycosyl transferase, family 2
CE463_RS07540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CE463_RS07550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CE463_RS07560	COG3089	Belongs to the UPF0270 family
CE463_RS07565	COG3706	GGDEF domain
CE463_RS07565	COG2203	Gaf domain
CE463_RS07565	COG5001	Diguanylate cyclase
CE463_RS07565	COG4251	negative regulation of phosphorylation
CE463_RS07570	COG0429	hydrolase of the alpha beta-hydrolase fold
CE463_RS07575	COG0835	chemotaxis
CE463_RS07575	COG0784	Response regulator, receiver
CE463_RS07585	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CE463_RS07590	COG1047	Peptidyl-prolyl cis-trans
CE463_RS07605	COG0545	Peptidyl-prolyl cis-trans isomerase
CE463_RS07610	COG2204	response regulator
CE463_RS07630	COG0737	Belongs to the 5'-nucleotidase family
CE463_RS07635	COG2200	EAL domain
CE463_RS07660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CE463_RS07665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CE463_RS07670	COG0826	peptidase U32
CE463_RS07675	COG2203	Gaf domain
CE463_RS07675	COG2200	EAL domain
CE463_RS07675	COG2199	diguanylate cyclase activity
CE463_RS07720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CE463_RS07725	COG2201	protein-glutamate methylesterase activity
CE463_RS07730	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CE463_RS07755	COG2916	Histone family protein nucleoid-structuring protein H-NS
CE463_RS07760	COG3328	transposase activity
CE463_RS07770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE463_RS07775	COG2375	cellular response to nickel ion
CE463_RS07780	COG1538	Outer membrane efflux protein
CE463_RS07785	COG0577	efflux transmembrane transporter activity
CE463_RS07785	COG1136	(ABC) transporter
CE463_RS07790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE463_RS07800	COG1227	inorganic diphosphatase activity
CE463_RS07805	COG0497	DNA recombination
CE463_RS07810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CE463_RS07815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CE463_RS07820	COG0443	Heat shock 70 kDa protein
CE463_RS07825	COG0484	heat shock protein binding
CE463_RS07855	COG1285	pathogenesis
CE463_RS07905	COG0095	Lipoate-protein ligase
CE463_RS07920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE463_RS07945	COG0708	Exodeoxyribonuclease III
CE463_RS08005	COG2814	Major facilitator Superfamily
CE463_RS08010	COG0109	protoheme IX farnesyltransferase activity
CE463_RS08020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CE463_RS08025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CE463_RS08060	COG1609	Transcriptional regulator
CE463_RS08065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE463_RS08065	COG1263	PTS System
CE463_RS08070	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CE463_RS08080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CE463_RS08085	COG5433	transposase activity
CE463_RS08100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE463_RS08115	COG2207	Transcriptional regulator
CE463_RS08120	COG0538	isocitrate dehydrogenase activity
CE463_RS08165	COG0582	viral genome integration into host DNA
CE463_RS08175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CE463_RS08180	COG2867	negative regulation of translational initiation
CE463_RS08185	COG2914	Belongs to the UPF0125 (RnfH) family
CE463_RS08190	COG0702	epimerase
CE463_RS08195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CE463_RS08225	COG4964	Belongs to the GSP D family
CE463_RS08235	COG2894	cell division
CE463_RS08275	COG1454	alcohol dehydrogenase
CE463_RS08290	COG1957	nucleoside hydrolase
CE463_RS08310	COG0840	transmembrane signaling receptor activity
CE463_RS08315	COG1280	lysine exporter protein (LysE YggA)
CE463_RS08325	COG5433	transposase activity
CE463_RS08330	COG4580	involved in the transport of maltose and maltodextrins
CE463_RS08340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE463_RS08340	COG1263	PTS System
CE463_RS08350	COG2171	N-acyltransferase activity
CE463_RS08360	COG0024	Methionine aminopeptidase
CE463_RS08365	COG0052	Belongs to the universal ribosomal protein uS2 family
CE463_RS08370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CE463_RS08375	COG0528	UMP kinase activity
CE463_RS08380	COG0233	cytoplasmic translational termination
CE463_RS08385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CE463_RS08390	COG0575	Belongs to the CDS family
CE463_RS08395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CE463_RS08400	COG0750	zinc metalloprotease
CE463_RS08415	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE463_RS08420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CE463_RS08425	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE463_RS08430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE463_RS08435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CE463_RS08445	COG0825	malonyl-CoA metabolic process
CE463_RS08450	COG3710	Transcriptional regulator
CE463_RS08455	COG0531	amino acid
CE463_RS08460	COG1982	Orn Lys Arg decarboxylase major
CE463_RS08465	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CE463_RS08480	COG0814	amino acid
CE463_RS08485	COG0531	amino acid
CE463_RS08495	COG0488	(ABC) transporter
CE463_RS08505	COG3590	peptidase
CE463_RS08510	COG0037	tRNA processing
CE463_RS08550	COG0366	Alpha amylase catalytic
CE463_RS08560	COG1881	PFAM PEBP family protein
CE463_RS08565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CE463_RS08570	COG0583	DNA-binding transcription factor activity
CE463_RS08580	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CE463_RS08590	COG0583	DNA-binding transcription factor activity
CE463_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
CE463_RS08600	COG0616	signal peptide processing
CE463_RS08605	COG3724	N-succinylarginine dihydrolase activity
CE463_RS08620	COG0840	transmembrane signaling receptor activity
CE463_RS08630	COG2971	BadF BadG BcrA BcrD
CE463_RS08640	COG4608	Belongs to the ABC transporter superfamily
CE463_RS08645	COG0444	Belongs to the ABC transporter superfamily
CE463_RS08650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE463_RS08700	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CE463_RS08705	COG1289	transmembrane transporter activity
CE463_RS08710	COG0303	'Molybdopterin
CE463_RS08715	COG0746	molybdenum cofactor guanylyltransferase activity
CE463_RS08725	COG4662	Binding-protein-dependent transport system inner membrane component
CE463_RS08740	COG3852	Histidine kinase
CE463_RS08750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CE463_RS08765	COG5433	transposase activity
CE463_RS08795	COG5433	transposase activity
CE463_RS08825	COG3383	formate dehydrogenase (NAD+) activity
CE463_RS08830	COG0437	4 iron, 4 sulfur cluster binding
CE463_RS08845	COG0281	malic enzyme
CE463_RS08855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE463_RS08860	COG0840	transmembrane signaling receptor activity
CE463_RS08875	COG0281	malic enzyme
CE463_RS08880	COG3290	protein histidine kinase activity
CE463_RS08895	COG0667	Aldo Keto reductase
CE463_RS08905	COG0697	spore germination
CE463_RS08925	COG2267	carboxylic ester hydrolase activity
CE463_RS08930	COG1942	4-Oxalocrotonate Tautomerase
CE463_RS08940	COG3284	Transcriptional regulator
CE463_RS08945	COG3706	GGDEF domain
CE463_RS08950	COG0346	lactoylglutathione lyase activity
CE463_RS08955	COG0745	RESPONSE REGULATOR receiver
CE463_RS08960	COG5002	protein histidine kinase activity
CE463_RS08980	COG1940	carbohydrate kinase activity
CE463_RS08985	COG3142	Participates in the control of copper homeostasis
CE463_RS08990	COG0545	Peptidyl-prolyl cis-trans isomerase
CE463_RS08995	COG1131	(ABC) transporter
CE463_RS09035	COG0019	diaminopimelate decarboxylase activity
CE463_RS09040	COG1115	amino acid carrier protein
CE463_RS09045	COG0095	Lipoate-protein ligase
CE463_RS09050	COG2233	PERMEase
CE463_RS09065	COG0534	Mate efflux family protein
CE463_RS09070	COG2207	Transcriptional regulator
CE463_RS09075	COG0281	malic enzyme
CE463_RS09110	COG0733	neurotransmitter:sodium symporter activity
CE463_RS09115	COG1752	Esterase of the alpha-beta hydrolase superfamily
CE463_RS09120	COG3706	GGDEF domain
CE463_RS09125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE463_RS09140	COG1032	radical SAM domain protein
CE463_RS09155	COG5433	transposase activity
CE463_RS09170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CE463_RS09175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CE463_RS09180	COG0741	lytic transglycosylase activity
CE463_RS09180	COG1196	nuclear chromosome segregation
CE463_RS09180	COG0739	heme binding
CE463_RS09185	COG0366	Alpha amylase catalytic
CE463_RS09205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CE463_RS09215	COG0788	formyltetrahydrofolate deformylase activity
CE463_RS09220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CE463_RS09230	COG3118	belongs to the thioredoxin family
CE463_RS09235	COG2091	lysine biosynthetic process via aminoadipic acid
CE463_RS09240	COG0791	NLP P60 protein
CE463_RS09245	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CE463_RS09260	COG1376	ErfK ybiS ycfS ynhG family protein
CE463_RS09260	COG1388	LysM domain
CE463_RS09310	COG1960	acyl-CoA dehydrogenase activity
CE463_RS09315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CE463_RS09325	COG0469	pyruvate kinase activity
CE463_RS09330	COG1737	Transcriptional regulator
CE463_RS09355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CE463_RS09375	COG1342	Belongs to the UPF0251 family
CE463_RS09430	COG1684	flagellar biosynthetic protein fliR
CE463_RS09440	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CE463_RS09465	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CE463_RS09475	COG0450	alkyl hydroperoxide reductase
CE463_RS09495	COG0500	methyltransferase
CE463_RS09500	COG4106	trans-aconitate 2-methyltransferase activity
CE463_RS09505	COG1801	Protein of unknown function DUF72
CE463_RS09520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CE463_RS09525	COG0217	transcriptional regulatory protein
CE463_RS09585	COG1940	carbohydrate kinase activity
CE463_RS09585	COG1846	Transcriptional regulator
CE463_RS09590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CE463_RS09595	COG0363	glucosamine-6-phosphate deaminase activity
CE463_RS09615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE463_RS09620	COG0735	belongs to the Fur family
CE463_RS09630	COG0716	FMN binding
CE463_RS09645	COG0596	Alpha beta hydrolase
CE463_RS09650	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CE463_RS09655	COG0033	Phosphoglucomutase
CE463_RS09665	COG1846	Transcriptional regulator
CE463_RS09670	COG2951	lytic endotransglycosylase activity
CE463_RS09675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CE463_RS09680	COG4136	ATPase activity
CE463_RS09685	COG4135	transport system, permease component
CE463_RS09690	COG4134	Bacterial extracellular solute-binding protein
CE463_RS09695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CE463_RS09700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CE463_RS09710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CE463_RS09715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CE463_RS09730	COG0729	surface antigen
CE463_RS09735	COG2911	Protein conserved in bacteria
CE463_RS09750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CE463_RS09775	COG1607	acyl-coa hydrolase
CE463_RS09785	COG3021	interspecies interaction between organisms
CE463_RS09790	COG0741	lytic transglycosylase activity
CE463_RS09790	COG1388	LysM domain
CE463_RS09795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE463_RS09800	COG2226	methyltransferase
CE463_RS09805	COG0328	RNA-DNA hybrid ribonuclease activity
CE463_RS09810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CE463_RS09820	COG3437	response regulator, receiver
CE463_RS09820	COG0784	Response regulator, receiver
CE463_RS09825	COG1960	acyl-CoA dehydrogenase activity
CE463_RS09830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CE463_RS09835	COG0121	glutamine amidotransferase
CE463_RS09865	COG2197	response regulator
CE463_RS09870	COG3850	Histidine kinase
CE463_RS09875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CE463_RS09880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CE463_RS09890	COG0243	molybdopterin cofactor binding
CE463_RS09895	COG0437	4 iron, 4 sulfur cluster binding
CE463_RS09900	COG0348	domain, Protein
CE463_RS09910	COG3005	denitrification pathway
CE463_RS09915	COG0521	Mo-molybdopterin cofactor biosynthetic process
CE463_RS09920	COG0315	cyclic pyranopterin monophosphate synthase activity
CE463_RS09925	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CE463_RS09930	COG0314	molybdopterin synthase activity
CE463_RS09945	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CE463_RS09950	COG0596	Alpha beta hydrolase
CE463_RS09975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CE463_RS09985	COG0302	gtp cyclohydrolase
CE463_RS09990	COG0840	transmembrane signaling receptor activity
CE463_RS09995	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CE463_RS10005	COG0583	DNA-binding transcription factor activity
CE463_RS10010	COG2353	YceI-like domain
CE463_RS10035	COG2195	Cleaves the N-terminal amino acid of tripeptides
CE463_RS10045	COG1166	arginine decarboxylase activity
CE463_RS10060	COG0346	lactoylglutathione lyase activity
CE463_RS10070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CE463_RS10075	COG1187	pseudouridine synthase activity
CE463_RS10080	COG2807	transmembrane transport
CE463_RS10090	COG0583	DNA-binding transcription factor activity
CE463_RS10110	COG2979	Protein of unknown function (DUF533)
CE463_RS10115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE463_RS10125	COG1294	oxidase, subunit
CE463_RS10135	COG1294	oxidase, subunit
CE463_RS10145	COG2814	Major facilitator Superfamily
CE463_RS10150	COG0656	L-ascorbic acid biosynthetic process
CE463_RS10155	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CE463_RS10180	COG0583	DNA-binding transcription factor activity
CE463_RS10185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CE463_RS10190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CE463_RS10195	COG2271	Major facilitator Superfamily
CE463_RS10200	COG1349	DNA-binding transcription factor activity
CE463_RS10210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CE463_RS10215	COG0584	glycerophosphoryl diester phosphodiesterase
CE463_RS10220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE463_RS10225	COG0287	Prephenate dehydrogenase
CE463_RS10225	COG1605	Chorismate mutase
CE463_RS10230	COG0583	DNA-binding transcription factor activity
CE463_RS10235	COG3085	chromosome segregation
CE463_RS10240	COG4574	serine-type endopeptidase inhibitor activity
CE463_RS10260	COG1770	oligopeptidase
CE463_RS10265	COG4771	TonB-dependent receptor
CE463_RS10280	COG3083	sulfuric ester hydrolase activity
CE463_RS10285	COG3082	Protein of unknown function (DUF1414)
CE463_RS10290	COG3081	Nucleoid-associated protein
CE463_RS10295	COG2182	Extracellular solute-binding protein
CE463_RS10300	COG1175	transmembrane transport
CE463_RS10305	COG3833	ABC-type maltose transport systems, permease component
CE463_RS10310	COG3842	ATPase activity
CE463_RS10325	COG0628	permease
CE463_RS10330	COG0425	Belongs to the sulfur carrier protein TusA family
CE463_RS10335	COG4783	chaperone-mediated protein folding
CE463_RS10345	COG1393	Belongs to the ArsC family
CE463_RS10355	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CE463_RS10360	COG2431	L-lysine efflux transmembrane transporter activity
CE463_RS10395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CE463_RS10405	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE463_RS10410	COG2373	Large extracellular alpha-helical protein
CE463_RS10415	COG4953	penicillin-binding protein 1C
CE463_RS10425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CE463_RS10425	COG0301	tRNA thio-modification
CE463_RS10440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CE463_RS10470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CE463_RS10480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CE463_RS10500	COG0483	inositol monophosphate 1-phosphatase activity
CE463_RS10510	COG0625	glutathione transferase activity
CE463_RS10520	COG0601	transmembrane transport
CE463_RS10525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE463_RS10530	COG0444	Belongs to the ABC transporter superfamily
CE463_RS10535	COG2814	Major facilitator Superfamily
CE463_RS10540	COG0583	DNA-binding transcription factor activity
CE463_RS10545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CE463_RS10550	COG0243	molybdopterin cofactor binding
CE463_RS10570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CE463_RS10575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CE463_RS10580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CE463_RS10585	COG0509	glycine decarboxylation via glycine cleavage system
CE463_RS10590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CE463_RS10590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CE463_RS10605	COG3634	alkyl hydroperoxide reductase activity
CE463_RS10615	COG0517	IMP dehydrogenase activity
CE463_RS10620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CE463_RS10625	COG0343	queuine tRNA-ribosyltransferase activity
CE463_RS10630	COG1862	Preprotein translocase
CE463_RS10635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE463_RS10640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE463_RS10645	COG2897	thiosulfate sulfurtransferase activity
CE463_RS10655	COG0826	peptidase U32
CE463_RS10660	COG0826	peptidase U32
CE463_RS10665	COG3154	lipid carrier protein
CE463_RS10680	COG1959	2 iron, 2 sulfur cluster binding
CE463_RS10685	COG1104	cysteine desulfurase activity
CE463_RS10690	COG0822	iron-sulfur transferase activity
CE463_RS10700	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CE463_RS10705	COG0443	Heat shock 70 kDa protein
CE463_RS10710	COG0633	Ferredoxin
CE463_RS10720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CE463_RS10725	COG0105	UTP biosynthetic process
CE463_RS10730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CE463_RS10740	COG1426	Protein conserved in bacteria
CE463_RS10745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CE463_RS10750	COG0124	histidyl-tRNA synthetase
CE463_RS10755	COG2976	Protein conserved in bacteria
CE463_RS10760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CE463_RS10765	COG1160	GTP binding
CE463_RS10770	COG1645	bacterial-type flagellum-dependent swarming motility
CE463_RS10775	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CE463_RS10780	COG0047	phosphoribosylformylglycinamidine synthase activity
CE463_RS10780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CE463_RS10790	COG2354	Protein conserved in bacteria
CE463_RS10805	COG5433	transposase activity
CE463_RS10815	COG5433	transposase activity
CE463_RS10825	COG5433	transposase activity
CE463_RS10830	COG1242	4 iron, 4 sulfur cluster binding
CE463_RS10900	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CE463_RS10905	COG1288	antiporter activity
CE463_RS10910	COG0436	Aminotransferase
CE463_RS10920	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CE463_RS10925	COG2027	D-alanyl-D-alanine carboxypeptidase
CE463_RS10930	COG1061	Type III restriction enzyme res subunit
CE463_RS10935	COG1566	PFAM secretion protein HlyD family protein
CE463_RS10945	COG1966	Carbon starvation protein
CE463_RS10950	COG3279	Response regulator of the LytR AlgR family
CE463_RS10955	COG3275	phosphorelay sensor kinase activity
CE463_RS10960	COG3437	response regulator, receiver
CE463_RS10975	COG1012	belongs to the aldehyde dehydrogenase family
CE463_RS10975	COG1454	alcohol dehydrogenase
CE463_RS10985	COG2095	MarC family integral membrane protein
CE463_RS10995	COG0601	transmembrane transport
CE463_RS11000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE463_RS11005	COG0444	Belongs to the ABC transporter superfamily
CE463_RS11020	COG0861	Integral membrane protein TerC family
CE463_RS11025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CE463_RS11035	COG1301	dicarboxylic acid transport
CE463_RS11050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CE463_RS11065	COG0537	adenosine 5'-monophosphoramidase activity
CE463_RS11100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE463_RS11105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CE463_RS11120	COG5433	transposase activity
CE463_RS11135	COG1007	ATP synthesis coupled electron transport
CE463_RS11140	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE463_RS11150	COG0713	ATP synthesis coupled electron transport
CE463_RS11155	COG0839	Belongs to the complex I subunit 6 family
CE463_RS11160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE463_RS11165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CE463_RS11170	COG1034	ATP synthesis coupled electron transport
CE463_RS11185	COG0649	NAD binding
CE463_RS11185	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE463_RS11190	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE463_RS11195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE463_RS11200	COG1360	Flagellar Motor Protein
CE463_RS11220	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CE463_RS11235	COG4597	amino acid ABC transporter
CE463_RS11240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE463_RS11245	COG0765	amino acid transport
CE463_RS11250	COG1126	abc transporter atp-binding protein
CE463_RS11260	COG0724	RNA recognition motif
CE463_RS11265	COG4989	oxidoreductase activity
CE463_RS11295	COG0583	DNA-binding transcription factor activity
CE463_RS11310	COG5001	Diguanylate cyclase
CE463_RS11310	COG3300	MHYT domain
CE463_RS11330	COG2814	Major facilitator Superfamily
CE463_RS11345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CE463_RS11350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CE463_RS11355	COG0539	negative regulation of cytoplasmic translation
CE463_RS11360	COG0776	regulation of translation
CE463_RS11370	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CE463_RS11375	COG0284	orotidine-5'-phosphate decarboxylase activity
CE463_RS11390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CE463_RS11395	COG0602	queuosine metabolic process
CE463_RS11400	COG3530	Putative quorum-sensing-regulated virulence factor
CE463_RS11405	COG2096	Adenosyltransferase
CE463_RS11410	COG2916	Histone family protein nucleoid-structuring protein H-NS
CE463_RS11425	COG1757	Na H antiporter
CE463_RS11430	COG1435	thymidine kinase activity
CE463_RS11455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CE463_RS11470	COG5433	transposase activity
CE463_RS11475	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CE463_RS11480	COG0437	4 iron, 4 sulfur cluster binding
CE463_RS11485	COG5557	Pfam Polysulphide reductase, NrfD
CE463_RS11490	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CE463_RS11495	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CE463_RS11500	COG1773	rubredoxin
CE463_RS11510	COG0601	transmembrane transport
CE463_RS11515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CE463_RS11530	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CE463_RS11535	COG0375	protein maturation
CE463_RS11540	COG0309	Hydrogenase expression formation protein (HypE)
CE463_RS11550	COG0298	carbon dioxide binding
CE463_RS11555	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CE463_RS11565	COG1921	L-seryl-tRNASec selenium transferase activity
CE463_RS11580	COG3260	NADH ubiquinone oxidoreductase 20
CE463_RS11585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE463_RS11590	COG3261	NADH dehydrogenase
CE463_RS11590	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CE463_RS11595	COG0650	Formate hydrogenlyase subunit 4
CE463_RS11600	COG0651	ATP synthesis coupled electron transport
CE463_RS11605	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CE463_RS11610	COG3158	transport of potassium into the cell
CE463_RS11655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CE463_RS11660	COG0326	Molecular chaperone. Has ATPase activity
CE463_RS11670	COG0563	adenylate kinase activity
CE463_RS11675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CE463_RS11680	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CE463_RS11685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE463_RS11690	COG0840	transmembrane signaling receptor activity
CE463_RS11745	COG1021	2,3-dihydroxybenzoate-AMP ligase
CE463_RS11750	COG3433	isochorismatase activity
CE463_RS11750	COG1535	isochorismatase
CE463_RS11755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CE463_RS11760	COG1028	Short-chain dehydrogenase reductase Sdr
CE463_RS11775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CE463_RS11780	COG2977	Belongs to the P-Pant transferase superfamily
CE463_RS11785	COG1120	ATPase activity
CE463_RS11790	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE463_RS11795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE463_RS11800	COG4771	TonB-dependent receptor
CE463_RS11840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CE463_RS11845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CE463_RS11850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE463_RS11865	COG1570	exodeoxyribonuclease VII activity
CE463_RS11880	COG3038	cytochrome b561
CE463_RS11885	COG5433	transposase activity
CE463_RS11910	COG0516	GMP reductase activity
CE463_RS11910	COG0517	IMP dehydrogenase activity
CE463_RS11915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CE463_RS11915	COG0519	Catalyzes the synthesis of GMP from XMP
CE463_RS11975	COG2062	phosphohistidine phosphatase, SixA
CE463_RS11985	COG0697	spore germination
CE463_RS11990	COG4166	transmembrane transport
CE463_RS11995	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CE463_RS12000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CE463_RS12010	COG4591	ABC-type transport system involved in lipoprotein release permease component
CE463_RS12015	COG1136	(ABC) transporter
CE463_RS12020	COG4591	ABC-type transport system involved in lipoprotein release permease component
CE463_RS12025	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CE463_RS12040	COG0544	peptidyl-prolyl cis-trans isomerase activity
CE463_RS12045	COG0740	serine-type endopeptidase activity
CE463_RS12050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CE463_RS12055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CE463_RS12060	COG0776	regulation of translation
CE463_RS12065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CE463_RS12070	COG0488	(ABC) transporter
CE463_RS12075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CE463_RS12080	COG3162	membrane
CE463_RS12095	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE463_RS12095	COG1024	Enoyl-CoA hydratase
CE463_RS12100	COG1115	amino acid carrier protein
CE463_RS12105	COG0456	acetyltransferase
CE463_RS12115	COG1584	GPR1 FUN34 yaaH family protein
CE463_RS12145	COG1024	Enoyl-CoA hydratase
CE463_RS12150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CE463_RS12155	COG1960	acyl-CoA dehydrogenase activity
CE463_RS12175	COG1960	acyl-CoA dehydrogenase activity
CE463_RS12180	COG1024	Enoyl-CoA hydratase
CE463_RS12185	COG1024	Enoyl-CoA hydratase
CE463_RS12195	COG1028	Short-chain dehydrogenase reductase Sdr
CE463_RS12205	COG0730	response to heat
CE463_RS12240	COG2378	regulation of single-species biofilm formation
CE463_RS12250	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CE463_RS12250	COG0140	phosphoribosyl-ATP diphosphatase activity
CE463_RS12255	COG0107	imidazoleglycerol-phosphate synthase activity
CE463_RS12260	COG2205	protein histidine kinase activity
CE463_RS12260	COG0784	Response regulator, receiver
CE463_RS12260	COG2198	Histidine kinase
CE463_RS12265	COG2199	diguanylate cyclase activity
CE463_RS12270	COG3437	response regulator, receiver
CE463_RS12275	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CE463_RS12280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CE463_RS12285	COG0131	Imidazoleglycerol-phosphate dehydratase
CE463_RS12285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CE463_RS12290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CE463_RS12295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CE463_RS12300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CE463_RS12310	COG1199	ATP-dependent helicase activity
CE463_RS12315	COG1214	PFAM Peptidase M22, glycoprotease
CE463_RS12325	COG2267	carboxylic ester hydrolase activity
CE463_RS12330	COG0318	PFAM AMP-dependent synthetase and ligase
CE463_RS12350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CE463_RS12355	COG2832	Protein of unknown function (DUF454)
CE463_RS12360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CE463_RS12365	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CE463_RS12370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CE463_RS12375	COG3314	Sporulation integral membrane protein YlbJ
CE463_RS12380	COG2197	response regulator
CE463_RS12385	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CE463_RS12385	COG0517	IMP dehydrogenase activity
CE463_RS12385	COG0617	tRNA 3'-terminal CCA addition
CE463_RS12390	COG1643	Atp-dependent helicase
CE463_RS12400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CE463_RS12405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CE463_RS12410	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CE463_RS12415	COG0709	Synthesizes selenophosphate from selenide and ATP
CE463_RS12430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CE463_RS12440	COG1254	Belongs to the acylphosphatase family
CE463_RS12445	COG0625	glutathione transferase activity
CE463_RS12450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE463_RS12450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE463_RS12455	COG0489	protein tyrosine kinase activity
CE463_RS12460	COG0572	uridine kinase
CE463_RS12465	COG0717	Belongs to the dCTP deaminase family
CE463_RS12470	COG0306	phosphate transporter
CE463_RS12475	COG1530	ribonuclease E activity
CE463_RS12485	COG0546	phosphoglycolate phosphatase activity
CE463_RS12495	COG1399	metal-binding, possibly nucleic acid-binding protein
CE463_RS12500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CE463_RS12505	COG0416	fatty acid biosynthetic process
CE463_RS12510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CE463_RS12520	COG1028	Short-chain dehydrogenase reductase Sdr
CE463_RS12525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE463_RS12530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE463_RS12535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CE463_RS12540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CE463_RS12545	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CE463_RS12550	COG0470	DNA polymerase III
CE463_RS12555	COG0084	hydrolase, TatD family'
CE463_RS12570	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CE463_RS12570	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CE463_RS12580	COG2995	paraquat-inducible protein a
CE463_RS12590	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CE463_RS12595	COG0372	Belongs to the citrate synthase family
CE463_RS12640	COG4221	oxidoreductase activity
CE463_RS12670	COG3620	sequence-specific DNA binding
CE463_RS12735	COG5433	transposase activity
CE463_RS12745	COG1067	ATP-dependent peptidase activity
CE463_RS12750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CE463_RS12765	COG0488	(ABC) transporter
CE463_RS12775	COG0116	Belongs to the methyltransferase superfamily
CE463_RS12775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CE463_RS12790	COG0167	dihydroorotate dehydrogenase activity
CE463_RS12800	COG5433	transposase activity
CE463_RS12815	COG0308	aminopeptidase N
CE463_RS12825	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CE463_RS12830	COG1956	GAF domain-containing protein
CE463_RS12840	COG3278	Belongs to the heme-copper respiratory oxidase family
CE463_RS12855	COG2010	Cytochrome c
CE463_RS12865	COG2217	Heavy metal translocating P-type atpase
CE463_RS12880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CE463_RS12885	COG0589	response to stress
CE463_RS12890	COG0037	tRNA processing
CE463_RS12910	COG1869	D-ribose catabolic process
CE463_RS12920	COG1172	Belongs to the binding-protein-dependent transport system permease family
CE463_RS12925	COG1879	ABC-type sugar transport system periplasmic component
CE463_RS12930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE463_RS12935	COG1609	Transcriptional regulator
CE463_RS12940	COG2199	diguanylate cyclase activity
CE463_RS12975	COG0776	regulation of translation
CE463_RS12980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE463_RS12980	COG0072	phenylalanine-tRNA ligase activity
CE463_RS12985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CE463_RS12990	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CE463_RS12995	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CE463_RS13000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CE463_RS13005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CE463_RS13025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CE463_RS13035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CE463_RS13040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CE463_RS13045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CE463_RS13050	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CE463_RS13055	COG3313	Fe-S protein
CE463_RS13060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE463_RS13060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE463_RS13060	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CE463_RS13065	COG1105	Belongs to the carbohydrate kinase PfkB family
CE463_RS13070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE463_RS13070	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE463_RS13075	COG1609	Transcriptional regulator
CE463_RS13080	COG0814	amino acid
CE463_RS13090	COG5654	RES domain protein
CE463_RS13095	COG0513	Belongs to the DEAD box helicase family
CE463_RS13105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CE463_RS13110	COG2890	protein-(glutamine-N5) methyltransferase activity
CE463_RS13115	COG2840	Smr protein MutS2
CE463_RS13120	COG3706	GGDEF domain
CE463_RS13170	COG2824	Alkylphosphonate utilization operon protein PhnA
CE463_RS13175	COG1024	Enoyl-CoA hydratase
CE463_RS13175	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE463_RS13180	COG0183	Belongs to the thiolase family
CE463_RS13185	COG0714	Associated with various cellular activities
CE463_RS13225	COG2067	long-chain fatty acid transport protein
CE463_RS13230	COG2067	long-chain fatty acid transport protein
CE463_RS13235	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CE463_RS13255	COG3123	guanosine phosphorylase activity
CE463_RS13260	COG1760	l-serine dehydratase
CE463_RS13270	COG1760	l-serine dehydratase
CE463_RS13275	COG2951	lytic endotransglycosylase activity
CE463_RS13280	COG3100	YcgL domain-containing protein
CE463_RS13285	COG0850	regulation of cytokinetic process
CE463_RS13290	COG2894	cell division
CE463_RS13295	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CE463_RS13300	COG3099	Belongs to the UPF0263 family
CE463_RS13305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CE463_RS13350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CE463_RS13355	COG0697	spore germination
CE463_RS13360	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CE463_RS13365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE463_RS13375	COG0307	riboflavin synthase, alpha
CE463_RS13385	COG0534	Mate efflux family protein
CE463_RS13420	COG0417	DNA replication proofreading
CE463_RS13450	COG1560	Kdo2-lipid A biosynthetic process
CE463_RS13460	COG0583	DNA-binding transcription factor activity
CE463_RS13465	COG0673	inositol 2-dehydrogenase activity
CE463_RS13470	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CE463_RS13475	COG0583	DNA-binding transcription factor activity
CE463_RS13485	COG2723	6-phospho-beta-galactosidase activity
CE463_RS13490	COG0583	DNA-binding transcription factor activity
CE463_RS13510	COG1288	antiporter activity
CE463_RS13520	COG3134	Outer membrane lipoprotein
CE463_RS13540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE463_RS13560	COG4681	YaeQ
CE463_RS13605	COG0242	peptide deformylase activity
CE463_RS13630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CE463_RS13635	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CE463_RS13640	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CE463_RS13650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CE463_RS13660	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CE463_RS13670	COG0205	6-phosphofructokinase activity
CE463_RS13705	COG1011	Hydrolase
CE463_RS13760	COG3593	DNA synthesis involved in DNA repair
CE463_RS13775	COG0583	DNA-binding transcription factor activity
CE463_RS13780	COG0730	response to heat
CE463_RS13785	COG3148	PFAM DTW domain containing protein
CE463_RS13795	COG1181	Belongs to the D-alanine--D-alanine ligase family
CE463_RS13805	COG0386	Belongs to the glutathione peroxidase family
CE463_RS13810	COG0513	Belongs to the DEAD box helicase family
CE463_RS13825	COG1742	UPF0060 membrane protein
CE463_RS13860	COG2329	Antibiotic biosynthesis monooxygenase
CE463_RS13865	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CE463_RS13885	COG3243	poly(R)-hydroxyalkanoic acid synthase
CE463_RS13895	COG2501	S4 domain
CE463_RS13905	COG1132	(ABC) transporter
CE463_RS13920	COG3118	belongs to the thioredoxin family
CE463_RS13925	COG0471	metal ion transport
CE463_RS13930	COG0058	SHG alpha-glucan phosphorylase activity
CE463_RS13975	COG5433	transposase activity
CE463_RS14000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CE463_RS14010	COG0814	amino acid
CE463_RS14015	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CE463_RS14020	COG0514	ATP-dependent DNA helicase (RecQ)
CE463_RS14025	COG2766	serine protein kinase
CE463_RS14035	COG2719	SpoVR family
CE463_RS14040	COG2186	Transcriptional regulator
CE463_RS14045	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE463_RS14050	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CE463_RS14055	COG0586	Pfam SNARE associated Golgi protein
CE463_RS14065	COG0556	nucleotide-excision repair
CE463_RS14080	COG0569	domain protein
CE463_RS14080	COG2985	domain, Protein
CE463_RS14085	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CE463_RS14090	COG5433	transposase activity
CE463_RS14120	COG4565	transcriptional regulatory protein
CE463_RS14125	COG3290	protein histidine kinase activity
CE463_RS14130	COG1940	carbohydrate kinase activity
CE463_RS14130	COG1846	Transcriptional regulator
CE463_RS14135	COG0840	transmembrane signaling receptor activity
CE463_RS14140	COG3012	SEC-C Motif Domain Protein
CE463_RS14145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CE463_RS14150	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CE463_RS14155	COG0247	lactate metabolic process
CE463_RS14165	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CE463_RS14170	COG0437	4 iron, 4 sulfur cluster binding
CE463_RS14175	COG3301	Polysulphide reductase, NrfD
CE463_RS14190	COG4235	cytochrome complex assembly
CE463_RS14190	COG3088	subunit of a heme lyase
CE463_RS14205	COG3033	Beta-eliminating lyase
CE463_RS14215	COG3046	protein related to deoxyribodipyrimidine photolyase
CE463_RS14245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CE463_RS14250	COG0583	DNA-binding transcription factor activity
CE463_RS14260	COG4774	siderophore transport
CE463_RS14265	COG2207	Transcriptional regulator
CE463_RS14265	COG3708	Transcriptional regulator
CE463_RS14275	COG0583	DNA-binding transcription factor activity
CE463_RS14280	COG2910	NAD(P)H-binding
CE463_RS14300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CE463_RS14305	COG1944	ATP diphosphatase activity
CE463_RS14310	COG2116	formate transmembrane transporter activity
CE463_RS14315	COG1882	Formate acetyltransferase
CE463_RS14320	COG2983	Belongs to the UPF0260 family
CE463_RS14325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CE463_RS14330	COG0045	succinate-CoA ligase (ADP-forming) activity
CE463_RS14335	COG0508	dehydrogenase complex catalyzes the overall conversion of
CE463_RS14340	COG0567	Dehydrogenase, E1 component
CE463_RS14350	COG1053	succinate dehydrogenase
CE463_RS14355	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CE463_RS14380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE463_RS14385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE463_RS14385	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CE463_RS14395	COG3069	C4-dicarboxylate transmembrane transporter activity
CE463_RS14410	COG1451	nucleotide metabolic process
CE463_RS14425	COG0254	rRNA binding
CE463_RS14430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CE463_RS14445	COG1874	Beta-galactosidase
CE463_RS14450	COG3867	Arabinogalactan endo-beta-1,4-galactanase
CE463_RS14455	COG3833	ABC-type maltose transport systems, permease component
CE463_RS14460	COG1175	transmembrane transport
CE463_RS14470	COG1175	transmembrane transport
CE463_RS14480	COG2182	Extracellular solute-binding protein
CE463_RS14520	COG4580	involved in the transport of maltose and maltodextrins
CE463_RS14530	COG1609	Transcriptional regulator
CE463_RS14535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE463_RS14540	COG1085	galactose-1-phosphate uridylyltransferase
CE463_RS14550	COG1085	galactose-1-phosphate uridylyltransferase
CE463_RS14555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CE463_RS14565	COG1172	Belongs to the binding-protein-dependent transport system permease family
CE463_RS14570	COG1129	ABC transporter
CE463_RS14575	COG1879	ABC-type sugar transport system periplasmic component
CE463_RS14580	COG1069	ribulokinase activity
CE463_RS14590	COG2160	L-arabinose isomerase activity
CE463_RS14595	COG0583	DNA-binding transcription factor activity
CE463_RS14600	COG0436	Aminotransferase
CE463_RS14605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CE463_RS14620	COG2925	Exonuclease
CE463_RS14630	COG3345	alpha-galactosidase
CE463_RS14640	COG1380	Effector of murein hydrolase LrgA
CE463_RS14645	COG1346	cytolysis
CE463_RS14650	COG0295	cytidine deaminase activity
CE463_RS14655	COG1022	Amp-dependent synthetase and ligase
CE463_RS14670	COG0861	Integral membrane protein TerC family
CE463_RS14680	COG2199	diguanylate cyclase activity
CE463_RS14695	COG2154	pterin-4-alpha-carbinolamine dehydratase
CE463_RS14705	COG3768	UPF0283 membrane protein
CE463_RS14710	COG3106	COG3106 Predicted ATPase
CE463_RS14725	COG1842	Phage shock protein A
CE463_RS14730	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CE463_RS14740	COG4168	peptide transport system, permease
CE463_RS14745	COG4171	peptide transport system, permease
CE463_RS14750	COG4172	Belongs to the ABC transporter superfamily
CE463_RS14755	COG4172	Belongs to the ABC transporter superfamily
CE463_RS14765	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CE463_RS14770	COG1286	toxin biosynthetic process
CE463_RS14775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CE463_RS14780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CE463_RS14785	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CE463_RS14790	COG1674	ftsk spoiiie
CE463_RS14790	COG0531	amino acid
CE463_RS14800	COG0686	Belongs to the AlaDH PNT family
CE463_RS14810	COG0492	ferredoxin-NADP+ reductase activity
CE463_RS14820	COG3134	Outer membrane lipoprotein
CE463_RS14825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CE463_RS14830	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CE463_RS14835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CE463_RS14840	COG0542	response to heat
CE463_RS14845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CE463_RS14850	COG1278	Cold shock
CE463_RS14855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CE463_RS14885	COG3501	Rhs element vgr protein
CE463_RS14915	COG3829	transcription factor binding
CE463_RS14980	COG0659	secondary active sulfate transmembrane transporter activity
CE463_RS15030	COG0697	spore germination
CE463_RS15035	COG4657	Part of a membrane complex involved in electron transport
CE463_RS15040	COG2878	Part of a membrane complex involved in electron transport
CE463_RS15050	COG4658	electron transport chain
CE463_RS15055	COG4659	FMN binding
CE463_RS15060	COG4660	Part of a membrane complex involved in electron transport
CE463_RS15065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CE463_RS15070	COG0346	lactoylglutathione lyase activity
CE463_RS15085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CE463_RS15090	COG2056	Na+-H+ antiporter family
CE463_RS15095	COG3300	MHYT domain
CE463_RS15095	COG5001	Diguanylate cyclase
CE463_RS15105	COG0513	Belongs to the DEAD box helicase family
CE463_RS15110	COG2050	protein possibly involved in aromatic compounds catabolism
CE463_RS15120	COG0277	FAD linked oxidase domain protein
CE463_RS15120	COG0247	lactate metabolic process
CE463_RS15130	COG1253	flavin adenine dinucleotide binding
CE463_RS15135	COG1902	pentaerythritol trinitrate reductase activity
CE463_RS15145	COG0647	UMP catabolic process
CE463_RS15150	COG4651	solute:proton antiporter activity
CE463_RS15150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE463_RS15160	COG0367	asparagine synthase
CE463_RS15185	COG0625	glutathione transferase activity
CE463_RS15190	COG0625	glutathione transferase activity
CE463_RS15215	COG0564	pseudouridine synthase activity
CE463_RS15230	COG5001	Diguanylate cyclase
CE463_RS15235	COG0840	transmembrane signaling receptor activity
CE463_RS15245	COG0670	Belongs to the BI1 family
CE463_RS15250	COG1289	transmembrane transporter activity
CE463_RS15255	COG2920	part of a sulfur-relay system
CE463_RS15260	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CE463_RS15265	COG0285	dihydrofolate synthase activity
CE463_RS15270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CE463_RS15275	COG0101	tRNA pseudouridine synthase activity
CE463_RS15285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CE463_RS15290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE463_RS15295	COG0671	phosphoesterase, PA-phosphatase related
CE463_RS15305	COG5433	transposase activity
CE463_RS15325	COG5433	transposase activity
CE463_RS15360	COG0574	Belongs to the PEP-utilizing enzyme family
CE463_RS15360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CE463_RS15365	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CE463_RS15375	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CE463_RS15420	COG0672	)-iron permease
CE463_RS15445	COG2814	Major facilitator Superfamily
CE463_RS15460	COG1136	(ABC) transporter
CE463_RS15465	COG0577	efflux transmembrane transporter activity
CE463_RS15480	COG1285	pathogenesis
CE463_RS15530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CE463_RS15535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CE463_RS15535	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CE463_RS15540	COG0527	aspartate kinase activity
CE463_RS15550	COG1368	sulfuric ester hydrolase activity
CE463_RS15555	COG1619	proteins homologs of microcin C7 resistance protein MccF
CE463_RS15565	COG0393	Putative heavy-metal-binding
CE463_RS15570	COG1252	NADH dehydrogenase
CE463_RS15575	COG3150	esterase
CE463_RS15590	COG3150	esterase
CE463_RS15610	COG0789	Transcriptional regulator
CE463_RS15625	COG0493	'glutamate synthase
CE463_RS15630	COG0067	glutamate synthase
CE463_RS15630	COG0069	glutamate synthase activity
CE463_RS15630	COG0070	glutamate synthase
CE463_RS15635	COG5433	transposase activity
CE463_RS15675	COG0513	Belongs to the DEAD box helicase family
CE463_RS15680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE463_RS15710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CE463_RS15715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CE463_RS15720	COG0505	Belongs to the CarA family
CE463_RS15725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CE463_RS15740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CE463_RS15745	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CE463_RS15750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CE463_RS15755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CE463_RS15760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CE463_RS15765	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CE463_RS15775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE463_RS15775	COG2205	protein histidine kinase activity
CE463_RS15820	COG2119	membrane
CE463_RS15850	COG2199	diguanylate cyclase activity
CE463_RS15850	COG2203	Gaf domain
CE463_RS15880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CE463_RS15890	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CE463_RS15895	COG2261	transglycosylase associated protein
CE463_RS15935	COG0322	excinuclease ABC activity
CE463_RS15940	COG2197	response regulator
CE463_RS15945	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CE463_RS15950	COG2835	tetraacyldisaccharide 4'-kinase activity
CE463_RS15955	COG1663	tetraacyldisaccharide 4'-kinase activity
CE463_RS15960	COG1132	(ABC) transporter
CE463_RS15965	COG2333	competence protein COMEC
CE463_RS15965	COG0658	competence protein
CE463_RS15980	COG0433	COG0433 Predicted ATPase
CE463_RS15985	COG1448	Aminotransferase
CE463_RS16000	COG1199	ATP-dependent helicase activity
CE463_RS16015	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CE463_RS16020	COG1785	Belongs to the alkaline phosphatase family
CE463_RS16040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CE463_RS16055	COG2271	Major facilitator Superfamily
CE463_RS16060	COG3706	GGDEF domain
CE463_RS16065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE463_RS16070	COG0765	amino acid transport
CE463_RS16075	COG1126	abc transporter atp-binding protein
CE463_RS16085	COG0531	amino acid
CE463_RS16100	COG1253	flavin adenine dinucleotide binding
CE463_RS16105	COG0704	Plays a role in the regulation of phosphate uptake
CE463_RS16110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CE463_RS16115	COG0581	inorganic phosphate transmembrane transporter activity
CE463_RS16120	COG0573	inorganic phosphate transmembrane transporter activity
CE463_RS16125	COG0590	tRNA wobble adenosine to inosine editing
CE463_RS16135	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CE463_RS16155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CE463_RS16160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CE463_RS16165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CE463_RS16170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CE463_RS16200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CE463_RS16205	COG0248	Ppx GppA phosphatase
CE463_RS16210	COG2239	Acts as a magnesium transporter
CE463_RS16240	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CE463_RS16250	COG4787	bacterial-type flagellum-dependent cell motility
CE463_RS16270	COG1815	bacterial-type flagellum-dependent cell motility
CE463_RS16275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CE463_RS16280	COG0784	Response regulator, receiver
CE463_RS16280	COG0835	chemotaxis
CE463_RS16300	COG0622	Phosphoesterase
CE463_RS16305	COG4166	transmembrane transport
CE463_RS16335	COG0697	spore germination
CE463_RS16375	COG1278	Cold shock
CE463_RS16430	COG3132	Protein of unknown function, DUF480
CE463_RS16445	COG5433	transposase activity
CE463_RS16465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CE463_RS16480	COG5433	transposase activity
CE463_RS16495	COG0471	metal ion transport
CE463_RS16495	COG3273	potassium ion transport
CE463_RS16500	COG5433	transposase activity
CE463_RS16520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CE463_RS16525	COG0438	transferase activity, transferring glycosyl groups
CE463_RS16545	COG1450	Type ii and iii secretion system protein
CE463_RS16580	COG1459	type II secretion system
CE463_RS16585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CE463_RS16605	COG1091	dTDP-4-dehydrorhamnose reductase activity
CE463_RS16630	COG1309	transcriptional regulator
CE463_RS16645	COG1946	Acyl-CoA thioesterase
CE463_RS16655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CE463_RS16665	COG0009	L-threonylcarbamoyladenylate synthase
CE463_RS16675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CE463_RS16680	COG0512	Glutamine amidotransferase of anthranilate synthase
CE463_RS16680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CE463_RS16685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CE463_RS16690	COG0134	indole-3-glycerol-phosphate synthase activity
CE463_RS16690	COG0135	phosphoribosylanthranilate isomerase activity
CE463_RS16695	COG0133	tryptophan synthase activity
CE463_RS16700	COG0159	tryptophan synthase activity
CE463_RS16720	COG5433	transposase activity
CE463_RS16735	COG5433	transposase activity
CE463_RS16755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE463_RS16755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE463_RS16755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE463_RS16765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CE463_RS16785	COG0482	sulfurtransferase activity
CE463_RS16790	COG2915	High frequency lysogenization protein hflD homolog
CE463_RS16795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CE463_RS16800	COG2850	peptidyl-arginine hydroxylation
CE463_RS16830	COG3153	acetyltransferase
CE463_RS16855	COG0259	pyridoxamine-phosphate oxidase activity
CE463_RS16870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CE463_RS16870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CE463_RS16875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CE463_RS16895	COG4235	cytochrome complex assembly
CE463_RS16895	COG3088	subunit of a heme lyase
CE463_RS16900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CE463_RS16905	COG1138	Cytochrome C-type biogenesis protein
CE463_RS16910	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CE463_RS16915	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CE463_RS16920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CE463_RS16925	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CE463_RS16940	COG0835	chemotaxis
CE463_RS16950	COG1192	Involved in chromosome partitioning
CE463_RS16955	COG1360	Flagellar Motor Protein
CE463_RS16960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CE463_RS16965	COG2201	protein-glutamate methylesterase activity
CE463_RS16970	COG2198	Histidine kinase
CE463_RS16970	COG0784	Response regulator, receiver
CE463_RS16970	COG0643	Histidine kinase
CE463_RS16980	COG0583	DNA-binding transcription factor activity
CE463_RS16990	COG0791	NLP P60 protein
CE463_RS17005	COG1309	transcriptional regulator
CE463_RS17045	COG0534	Mate efflux family protein
CE463_RS17055	COG2841	Protein conserved in bacteria
CE463_RS17060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CE463_RS17060	COG1013	pyruvate-flavodoxin oxidoreductase activity
CE463_RS17060	COG0674	pyruvate-flavodoxin oxidoreductase activity
CE463_RS17060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CE463_RS17075	COG3217	Mosc domain protein beta barrel domain protein
CE463_RS17075	COG0633	Ferredoxin
CE463_RS17075	COG0633	Ferredoxin
CE463_RS17075	COG3217	Mosc domain protein beta barrel domain protein
CE463_RS17085	COG0501	Belongs to the peptidase M48B family
CE463_RS17090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CE463_RS17095	COG2226	methyltransferase
CE463_RS17095	COG1073	alpha beta
CE463_RS17100	COG0156	8-amino-7-oxononanoate synthase activity
CE463_RS17105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CE463_RS17125	COG0017	Asparaginyl-tRNA synthetase
CE463_RS17130	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CE463_RS17145	COG0583	DNA-binding transcription factor activity
CE463_RS17150	COG1393	Belongs to the ArsC family
CE463_RS17155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CE463_RS17160	COG1876	peptidase activity
CE463_RS17170	COG3263	regulation of cellular component size
CE463_RS17190	COG5433	transposase activity
CE463_RS17200	COG0564	pseudouridine synthase activity
CE463_RS17205	COG3098	single-species biofilm formation
CE463_RS17230	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CE463_RS17240	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CE463_RS17240	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CE463_RS17255	COG1611	Belongs to the LOG family
CE463_RS17260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CE463_RS17265	COG0473	3-isopropylmalate dehydrogenase activity
CE463_RS17275	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CE463_RS17280	COG2363	Small membrane protein
CE463_RS17290	COG0583	DNA-binding transcription factor activity
CE463_RS17295	COG0840	transmembrane signaling receptor activity
CE463_RS17300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CE463_RS17315	COG1477	protein flavinylation
CE463_RS17320	COG2871	sodium ion transport
CE463_RS17325	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE463_RS17330	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE463_RS17335	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE463_RS17340	COG1805	sodium ion transport
CE463_RS17345	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CE463_RS17350	COG0271	Belongs to the BolA IbaG family
CE463_RS17360	COG2813	Specifically methylates the guanine in position
CE463_RS17370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CE463_RS17380	COG2211	Major facilitator Superfamily
CE463_RS17385	COG3248	Nucleoside-binding outer membrane protein
CE463_RS17390	COG1666	GTP binding
CE463_RS17395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CE463_RS17400	COG0693	protein deglycase activity
CE463_RS17420	COG3459	Glycosyltransferase 36 associated
CE463_RS17435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CE463_RS17435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CE463_RS17440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CE463_RS17450	COG1151	hydroxylamine reductase activity
CE463_RS17455	COG0783	Belongs to the Dps family
CE463_RS17480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CE463_RS17495	COG0300	oxidoreductase activity
CE463_RS17505	COG0415	Belongs to the DNA photolyase family
CE463_RS17510	COG0789	Transcriptional regulator
CE463_RS17515	COG3272	Protein of unknown function (DUF1722)
CE463_RS17545	COG0077	Prephenate dehydratase
CE463_RS17545	COG1605	Chorismate mutase
CE463_RS17570	COG2133	pyrroloquinoline quinone binding
CE463_RS17595	COG0300	oxidoreductase activity
CE463_RS17620	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CE463_RS17635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CE463_RS17645	COG3813	Protein conserved in bacteria
CE463_RS17660	COG1280	lysine exporter protein (LysE YggA)
CE463_RS17670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CE463_RS17675	COG0840	transmembrane signaling receptor activity
CE463_RS17680	COG0745	RESPONSE REGULATOR receiver
CE463_RS17700	COG0835	chemotaxis
CE463_RS17705	COG0840	transmembrane signaling receptor activity
CE463_RS17715	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CE463_RS17735	COG5433	transposase activity
CE463_RS17740	COG1917	Cupin 2, conserved barrel domain protein
CE463_RS17740	COG2169	Transcriptional regulator
CE463_RS17750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CE463_RS17755	COG1396	sequence-specific DNA binding
CE463_RS17755	COG1917	Cupin 2, conserved barrel domain protein
CE463_RS17770	COG0531	amino acid
CE463_RS17775	COG0531	amino acid
CE463_RS17780	COG1283	sodium-dependent phosphate transmembrane transporter activity
CE463_RS17790	COG3384	dioxygenase
CE463_RS17805	COG0813	purine-nucleoside phosphorylase activity
CE463_RS17830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CE463_RS17835	COG0083	homoserine kinase activity
CE463_RS17845	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CE463_RS17850	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CE463_RS17865	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CE463_RS17875	COG0745	RESPONSE REGULATOR receiver
CE463_RS17890	COG4988	ABC transporter
CE463_RS17895	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CE463_RS17915	COG1720	tRNA m6t6A37 methyltransferase activity
CE463_RS17935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CE463_RS17940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE463_RS17950	COG2190	(PTS) system
CE463_RS17965	COG3038	cytochrome b561
CE463_RS17975	COG5433	transposase activity
CE463_RS17985	COG0419	ATPase involved in DNA repair
CE463_RS17990	COG0420	3'-5' exonuclease activity
CE463_RS18000	COG2974	May be involved in recombination
CE463_RS18005	COG0405	Gamma-glutamyltransferase
CE463_RS18010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE463_RS18010	COG4651	solute:proton antiporter activity
CE463_RS18015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CE463_RS18015	COG4651	solute:proton antiporter activity
CE463_RS18030	COG0469	pyruvate kinase activity
CE463_RS18035	COG1196	nuclear chromosome segregation
CE463_RS18035	COG3264	Mechanosensitive ion channel
CE463_RS18040	COG0582	viral genome integration into host DNA
CE463_RS18055	COG1846	Transcriptional regulator
CE463_RS18060	COG1566	PFAM secretion protein HlyD family protein
CE463_RS18085	COG0602	queuosine metabolic process
CE463_RS18095	COG1328	CTP reductase activity
CE463_RS18105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CE463_RS18110	COG3115	cell septum assembly
CE463_RS18115	COG1196	nuclear chromosome segregation
CE463_RS18125	COG2860	membrane
CE463_RS18135	COG3108	Peptidase M15
CE463_RS18140	COG2989	Protein conserved in bacteria
CE463_RS18155	COG0463	Glycosyl transferase, family 2
CE463_RS18175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CE463_RS18180	COG0739	heme binding
CE463_RS18185	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CE463_RS18205	COG5433	transposase activity
CE463_RS18210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CE463_RS18220	COG3091	SprT-like family
CE463_RS18230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CE463_RS18235	COG0189	ligase activity
CE463_RS18255	COG1678	Uncharacterized ACR, COG1678
CE463_RS18260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CE463_RS18280	COG0714	Associated with various cellular activities
CE463_RS18295	COG1115	amino acid carrier protein
CE463_RS18300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CE463_RS18315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CE463_RS18335	COG1301	dicarboxylic acid transport
CE463_RS18345	COG1301	dicarboxylic acid transport
CE463_RS18355	COG2912	Transglutaminase-like superfamily
CE463_RS18365	COG2890	protein-(glutamine-N5) methyltransferase activity
CE463_RS18370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CE463_RS18375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CE463_RS18380	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CE463_RS18385	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CE463_RS18395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CE463_RS18400	COG0737	Belongs to the 5'-nucleotidase family
CE463_RS18405	COG0193	aminoacyl-tRNA hydrolase activity
CE463_RS18410	COG0012	GTP binding
CE463_RS18455	COG0490	domain, Protein
CE463_RS18455	COG0471	metal ion transport
CE463_RS18465	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CE463_RS18500	COG0443	Heat shock 70 kDa protein
CE463_RS18515	COG0366	Alpha amylase catalytic
CE463_RS18530	COG0488	(ABC) transporter
CE463_RS18540	COG0674	pyruvate-flavodoxin oxidoreductase activity
CE463_RS18540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CE463_RS18540	COG1013	pyruvate-flavodoxin oxidoreductase activity
CE463_RS18540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CE463_RS18550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE463_RS18560	COG1012	belongs to the aldehyde dehydrogenase family
CE463_RS18570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CE463_RS18585	COG0180	Tryptophanyl-tRNA synthetase
CE463_RS18590	COG0546	phosphoglycolate phosphatase activity
CE463_RS18595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CE463_RS18600	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CE463_RS18610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CE463_RS18615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CE463_RS18645	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CE463_RS18650	COG0583	DNA-binding transcription factor activity
CE463_RS18655	COG0840	transmembrane signaling receptor activity
CE463_RS18670	COG0583	DNA-binding transcription factor activity
CE463_RS18685	COG0739	heme binding
CE463_RS18715	COG0584	glycerophosphoryl diester phosphodiesterase
CE463_RS18725	COG1053	succinate dehydrogenase
CE463_RS18730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CE463_RS18735	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CE463_RS18740	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CE463_RS18760	COG3214	Protein conserved in bacteria
CE463_RS18800	COG0642	Histidine kinase
CE463_RS18810	COG0516	GMP reductase activity
CE463_RS18820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CE463_RS18830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CE463_RS18850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CE463_RS18865	COG3706	GGDEF domain
CE463_RS18875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CE463_RS18880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CE463_RS18885	COG1702	phosphate starvation-inducible protein PhoH
CE463_RS18890	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CE463_RS18895	COG4535	Mg2 and Co2 transporter CorC
CE463_RS18900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CE463_RS18905	COG2888	peptidyl-tyrosine sulfation
CE463_RS18910	COG0495	leucyl-tRNA aminoacylation
CE463_RS18930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CE463_RS18935	COG0799	negative regulation of ribosome biogenesis
CE463_RS18940	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CE463_RS18945	COG0768	penicillin binding
CE463_RS18950	COG0772	Belongs to the SEDS family
CE463_RS18955	COG2951	lytic endotransglycosylase activity
CE463_RS18960	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CE463_RS18965	COG1686	Belongs to the peptidase S11 family
CE463_RS18970	COG2921	Belongs to the UPF0250 family
CE463_RS18975	COG0321	lipoyl(octanoyl) transferase activity
CE463_RS18985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CE463_RS19000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CE463_RS19005	COG3545	Serine hydrolase
CE463_RS19020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CE463_RS19030	COG1970	mechanosensitive ion channel activity
CE463_RS19040	COG4974	Belongs to the 'phage' integrase family
CE463_RS19055	COG0312	modulator of DNA gyrase
CE463_RS19100	COG5433	transposase activity
CE463_RS19115	COG1422	Protein of unknown function (DUF1090)
CE463_RS19120	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CE463_RS19125	COG3706	GGDEF domain
CE463_RS19130	COG2211	Major facilitator Superfamily
CE463_RS19135	COG1185	polyribonucleotide nucleotidyltransferase activity
CE463_RS19140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CE463_RS19145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CE463_RS19150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CE463_RS19155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CE463_RS19160	COG0195	Participates in both transcription termination and antitermination
CE463_RS19165	COG0779	Required for maturation of 30S ribosomal subunits
CE463_RS19180	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CE463_RS19185	COG0149	triose-phosphate isomerase activity
CE463_RS19190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CE463_RS19195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CE463_RS19205	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CE463_RS19210	COG1534	Rna-binding protein
CE463_RS19235	COG1360	Flagellar Motor Protein
CE463_RS19240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CE463_RS19245	COG1722	exodeoxyribonuclease VII activity
CE463_RS19250	COG0142	geranyltranstransferase activity
CE463_RS19255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CE463_RS19265	COG0601	transmembrane transport
CE463_RS19275	COG4172	Belongs to the ABC transporter superfamily
CE463_RS19280	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CE463_RS19285	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CE463_RS19290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CE463_RS19295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CE463_RS19310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CE463_RS19310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CE463_RS19315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CE463_RS19330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CE463_RS19350	COG3381	protein complex oligomerization
CE463_RS19380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CE463_RS19385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CE463_RS19390	COG0511	ligase activity, forming carbon-carbon bonds
CE463_RS19395	COG0439	Biotin carboxylase
CE463_RS19400	COG3924	membrane
CE463_RS19405	COG4145	pantothenate transmembrane transporter activity
CE463_RS19410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CE463_RS19410	COG2190	(PTS) system
CE463_RS19410	COG1263	PTS System
CE463_RS19415	COG0583	DNA-binding transcription factor activity
CE463_RS19420	COG0604	alcohol dehydrogenase
CE463_RS19425	COG2264	protein methyltransferase activity
CE463_RS19430	COG0531	amino acid
CE463_RS19435	COG4303	Ethanolamine ammonia lyase large subunit
CE463_RS19440	COG4302	ethanolamine ammonia-lyase activity
CE463_RS19460	COG0778	Nitroreductase
CE463_RS19465	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE463_RS19465	COG1902	pentaerythritol trinitrate reductase activity
CE463_RS19470	COG0616	signal peptide processing
CE463_RS19490	COG3139	Protein of unknown function (DUF1315)
CE463_RS19495	COG0252	asparaginase activity
CE463_RS19500	COG0786	glutamate:sodium symporter activity
CE463_RS19515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CE463_RS19520	COG0384	phenazine biosynthesis protein PhzF
CE463_RS19525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CE463_RS19530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CE463_RS19535	COG0175	sulfate reduction
CE463_RS19540	COG2113	Glycine betaine
CE463_RS19545	COG4176	ABC-type proline glycine betaine transport system permease component
CE463_RS19550	COG4175	Glycine betaine
CE463_RS19560	COG3610	response to peptide
CE463_RS19565	COG2966	Psort location CytoplasmicMembrane, score
CE463_RS19580	COG0521	Mo-molybdopterin cofactor biosynthetic process
CE463_RS19590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE463_RS19595	COG1028	Short-chain dehydrogenase reductase Sdr
CE463_RS19605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CE463_RS19630	COG2986	histidine ammonia-lyase
CE463_RS19645	COG0318	PFAM AMP-dependent synthetase and ligase
CE463_RS19655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE463_RS19660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CE463_RS19705	COG1858	cytochrome C peroxidase
CE463_RS19710	COG5433	transposase activity
CE463_RS19720	COG2313	pseudouridylate synthase activity
CE463_RS19725	COG1522	sequence-specific DNA binding
CE463_RS19725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE463_RS19755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CE463_RS19760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CE463_RS19770	COG1073	alpha beta
CE463_RS19775	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CE463_RS19790	COG2195	Cleaves the N-terminal amino acid of tripeptides
CE463_RS19800	COG4608	Belongs to the ABC transporter superfamily
CE463_RS19805	COG0444	Belongs to the ABC transporter superfamily
CE463_RS19810	COG0747	negative chemotaxis
CE463_RS19815	COG4239	(ABC) transporter, permease
CE463_RS19820	COG4174	ABC transporter (Permease)
CE463_RS19830	COG0601	transmembrane transport
CE463_RS19835	COG5433	transposase activity
CE463_RS19840	COG4206	TonB-dependent receptor
CE463_RS19850	COG0811	peptide transport
CE463_RS19855	COG0811	peptide transport
CE463_RS19860	COG0848	biopolymer transport protein
CE463_RS19915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CE463_RS19930	COG1278	Cold shock
CE463_RS19970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CE463_RS19980	COG0688	phosphatidylethanolamine metabolic process
CE463_RS19985	COG4628	conserved protein (DUF2132)
CE463_RS20005	COG3300	MHYT domain
CE463_RS20005	COG5001	Diguanylate cyclase
CE463_RS20010	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CE463_RS20040	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CE463_RS20045	COG1012	belongs to the aldehyde dehydrogenase family
CE463_RS20060	COG1132	(ABC) transporter
CE463_RS20070	COG2897	thiosulfate sulfurtransferase activity
CE463_RS20075	COG2066	Belongs to the glutaminase family
CE463_RS20080	COG3171	Protein conserved in bacteria
CE463_RS20085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CE463_RS20090	COG4935	Belongs to the peptidase S8 family
CE463_RS20090	COG2234	aminopeptidase activity
CE463_RS20095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CE463_RS20100	COG2200	EAL domain
CE463_RS20105	COG1090	epimerase
CE463_RS20110	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CE463_RS20115	COG4181	ATPase activity
CE463_RS20120	COG2755	lipolytic protein G-D-S-L family
CE463_RS20125	COG0835	chemotaxis
CE463_RS20125	COG0784	Response regulator, receiver
CE463_RS20135	COG2985	domain, Protein
CE463_RS20135	COG0569	domain protein
CE463_RS20140	COG1272	protein, Hemolysin III
CE463_RS20145	COG0076	glutamate decarboxylase activity
CE463_RS20150	COG2917	probably involved in intracellular septation
CE463_RS20155	COG2350	Protein conserved in bacteria
CE463_RS20165	COG1555	photosystem II stabilization
CE463_RS20170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CE463_RS20175	COG3104	oligopeptide transport
CE463_RS20180	COG0745	RESPONSE REGULATOR receiver
CE463_RS20210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CE463_RS20225	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CE463_RS20230	COG1280	lysine exporter protein (LysE YggA)
CE463_RS20290	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CE463_RS20310	COG0513	Belongs to the DEAD box helicase family
CE463_RS20345	COG3385	transposase activity
CE463_RS20450	COG0582	viral genome integration into host DNA
CE463_RS20465	COG0795	lipopolysaccharide-transporting ATPase activity
CE463_RS20470	COG0795	lipopolysaccharide-transporting ATPase activity
CE463_RS20475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CE463_RS20480	COG2927	DNA polymerase III (CHI subunit)
CE463_RS20490	COG1253	flavin adenine dinucleotide binding
CE463_RS20495	COG0586	Pfam SNARE associated Golgi protein
CE463_RS20500	COG1686	Belongs to the peptidase S11 family
CE463_RS20525	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CE463_RS20530	COG0527	aspartate kinase activity
CE463_RS20535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CE463_RS20545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CE463_RS20550	COG1546	Belongs to the CinA family
CE463_RS20555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CE463_RS20595	COG1346	cytolysis
CE463_RS20610	COG0460	homoserine dehydrogenase
CE463_RS20610	COG0527	aspartate kinase activity
CE463_RS20615	COG0626	cystathionine gamma-synthase activity
CE463_RS20630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CE463_RS20635	COG0814	amino acid
CE463_RS20640	COG1218	3'(2'),5'-bisphosphate nucleotidase
CE463_RS20645	COG0494	nUDIX hydrolase
CE463_RS20650	COG1011	Hydrolase
CE463_RS20655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CE463_RS20670	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CE463_RS20680	COG3156	type II secretion system protein K
CE463_RS20685	COG4795	General secretion pathway protein
CE463_RS20690	COG2165	general secretion pathway protein
CE463_RS20700	COG2165	general secretion pathway protein
CE463_RS20705	COG1459	type II secretion system
CE463_RS20710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CE463_RS20730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CE463_RS20735	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CE463_RS20755	COG0456	acetyltransferase
CE463_RS20760	COG3133	Outer membrane lipoprotein
CE463_RS20775	COG2771	luxR family
CE463_RS20790	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CE463_RS20805	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE463_RS20805	COG2213	PTS system mannitol-specific
CE463_RS20810	COG0246	Mannitol dehydrogenase
CE463_RS20815	COG3722	fumarate hydratase activity
CE463_RS20820	COG3263	regulation of cellular component size
CE463_RS20825	COG0484	heat shock protein binding
CE463_RS20845	COG1671	Belongs to the UPF0178 family
CE463_RS20860	COG1988	membrane-bound metal-dependent
CE463_RS20865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CE463_RS20875	COG0513	Belongs to the DEAD box helicase family
CE463_RS20900	COG1575	Belongs to the MenA family. Type 1 subfamily
CE463_RS20905	COG1169	isochorismate synthase
CE463_RS20910	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CE463_RS20915	COG0596	Alpha beta hydrolase
CE463_RS20920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CE463_RS20930	COG0318	PFAM AMP-dependent synthetase and ligase
CE463_RS20940	COG5433	transposase activity
CE463_RS20960	COG3188	usher protein
CE463_RS20970	COG3188	usher protein
CE463_RS21005	COG5433	transposase activity
CE463_RS21025	COG2949	membrane
CE463_RS21030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CE463_RS21040	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CE463_RS21045	COG5380	lipid catabolic process
CE463_RS21060	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CE463_RS21075	COG2873	o-acetylhomoserine
CE463_RS21105	COG4221	oxidoreductase activity
CE463_RS21125	COG1285	pathogenesis
CE463_RS21145	COG1368	sulfuric ester hydrolase activity
CE463_RS21150	COG1522	sequence-specific DNA binding
CE463_RS21160	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CE463_RS21165	COG1418	mRNA catabolic process
CE463_RS21170	COG1546	Belongs to the CinA family
CE463_RS21170	COG1058	Belongs to the CinA family
CE463_RS21180	COG0842	Transport permease protein
CE463_RS21180	COG1129	ABC transporter
CE463_RS21205	COG0561	phosphatase activity
CE463_RS21210	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CE463_RS21220	COG0668	transmembrane transport
CE463_RS21230	COG1011	Hydrolase
CE463_RS21245	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CE463_RS21250	COG0019	diaminopimelate decarboxylase activity
CE463_RS21255	COG1965	Belongs to the frataxin family
CE463_RS21260	COG0400	carboxylic ester hydrolase activity
CE463_RS21265	COG3072	Adenylate cyclase
CE463_RS21270	COG0181	hydroxymethylbilane synthase activity
CE463_RS21280	COG2959	enzyme of heme biosynthesis
CE463_RS21295	COG1494	fructose-1,6-bisphosphatase
CE463_RS21345	COG3932	Exopolysaccharide synthesis, ExoD
CE463_RS21350	COG0814	amino acid
CE463_RS21355	COG5433	transposase activity
CE463_RS21390	COG2022	thiamine diphosphate biosynthetic process
CE463_RS21400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CE463_RS21405	COG0352	thiamine-phosphate diphosphorylase activity
CE463_RS21410	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CE463_RS21460	COG3385	transposase activity
CE463_RS21510	COG3328	transposase activity
CE463_RS21525	COG2957	Belongs to the agmatine deiminase family
CE463_RS21535	COG4221	oxidoreductase activity
CE463_RS21550	COG1024	Enoyl-CoA hydratase
CE463_RS21560	COG0110	maltose O-acetyltransferase activity
CE463_RS21570	COG4166	transmembrane transport
CE463_RS21585	COG1872	DUF167
CE463_RS21590	COG0762	integral membrane protein
CE463_RS21595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CE463_RS21600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CE463_RS21615	COG3022	response to hydroperoxide
CE463_RS21620	COG0513	Belongs to the DEAD box helicase family
CE463_RS21625	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CE463_RS21645	COG0735	belongs to the Fur family
CE463_RS21650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CE463_RS21665	COG0776	regulation of translation
CE463_RS21670	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CE463_RS21695	COG0560	Phosphoserine phosphatase
CE463_RS21705	COG0813	purine-nucleoside phosphorylase activity
CE463_RS21710	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CE463_RS21715	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CE463_RS21720	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CE463_RS21735	COG0084	hydrolase, TatD family'
CE463_RS21740	COG2165	general secretion pathway protein
CE463_RS21755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CE463_RS21760	COG0004	ammonium transporteR
CE463_RS21795	COG0745	RESPONSE REGULATOR receiver
CE463_RS21800	COG0642	Histidine kinase
CE463_RS21805	COG0189	ligase activity
CE463_RS21835	COG1639	'signal transduction protein
CE463_RS21845	COG3700	Belongs to the class B bacterial acid phosphatase family
CE463_RS21855	COG1366	Belongs to the anti-sigma-factor antagonist family
CE463_RS21860	COG2172	sigma factor antagonist activity
CE463_RS21865	COG2205	protein histidine kinase activity
CE463_RS21865	COG5002	protein histidine kinase activity
CE463_RS21865	COG0784	Response regulator, receiver
CE463_RS21870	COG3437	response regulator, receiver
CE463_RS21880	COG0477	Major facilitator Superfamily
CE463_RS21895	COG0312	modulator of DNA gyrase
CE463_RS21900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CE463_RS21910	COG3164	Protein of unknown function
CE463_RS21915	COG1530	ribonuclease E activity
CE463_RS21920	COG0424	maF-like protein
CE463_RS21925	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CE463_RS21930	COG1792	Involved in formation and maintenance of cell shape
CE463_RS21935	COG1077	Cell shape determining protein MreB Mrl
CE463_RS21995	COG2199	diguanylate cyclase activity
CE463_RS21995	COG2200	EAL domain
CE463_RS22000	COG2264	protein methyltransferase activity
CE463_RS22005	COG0387	Pfam Sodium calcium exchanger
CE463_RS22010	COG2986	histidine ammonia-lyase
CE463_RS22015	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CE463_RS22020	COG0010	Belongs to the arginase family
CE463_RS22025	COG1228	amidohydrolase
CE463_RS22030	COG2188	Transcriptional regulator
CE463_RS22035	COG0288	reversible hydration of carbon dioxide
CE463_RS22045	COG2177	Part of the ABC transporter FtsEX involved in
CE463_RS22050	COG2884	Cell division ATP-binding protein ftsE
CE463_RS22055	COG0552	protein localization to endoplasmic reticulum
CE463_RS22060	COG0742	ribosomal rna small subunit methyltransferase
CE463_RS22085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CE463_RS22090	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CE463_RS22100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CE463_RS22110	COG2095	MarC family integral membrane protein
CE463_RS22120	COG1301	dicarboxylic acid transport
CE463_RS22145	COG3714	YhhN family
CE463_RS22165	COG1770	oligopeptidase
CE463_RS22180	COG2249	NAD(P)H dehydrogenase (quinone) activity
CE463_RS22225	COG1987	bacterial-type flagellum assembly
CE463_RS22250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CE463_RS22255	COG3107	peptidoglycan biosynthetic process
CE463_RS22260	COG0792	nuclease activity
CE463_RS22265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CE463_RS22270	COG2823	Periplasmic or secreted lipoprotein
CE463_RS22275	COG2969	positive regulation of protein catabolic process
CE463_RS22280	COG0625	glutathione transferase activity
CE463_RS22285	COG2857	Cytochrome c1
CE463_RS22290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CE463_RS22295	COG0723	plastoquinol--plastocyanin reductase activity
CE463_RS22300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CE463_RS22305	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CE463_RS22310	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CE463_RS22320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CE463_RS22325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CE463_RS22360	COG3964	amidohydrolase
CE463_RS22380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE463_RS22385	COG1660	Displays ATPase and GTPase activities
CE463_RS22390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CE463_RS22400	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CE463_RS22405	COG1137	ATPase activity
CE463_RS22410	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CE463_RS22415	COG3117	lipopolysaccharide transmembrane transporter activity
CE463_RS22420	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CE463_RS22425	COG0517	IMP dehydrogenase activity
CE463_RS22425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CE463_RS22430	COG1127	ABC transporter
CE463_RS22435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CE463_RS22440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CE463_RS22445	COG2854	intermembrane phospholipid transfer
CE463_RS22455	COG5007	Belongs to the BolA IbaG family
CE463_RS22460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CE463_RS22465	COG0312	modulator of DNA gyrase
CE463_RS22470	COG3028	Belongs to the UPF0307 family
CE463_RS22480	COG2926	Belongs to the UPF0265 family
CE463_RS22520	COG0203	ribosomal protein L17
CE463_RS22525	COG0202	RNA polymerase activity
CE463_RS22530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CE463_RS22535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CE463_RS22540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CE463_RS22545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CE463_RS22550	COG0201	protein transport
CE463_RS22555	COG0200	Binds to the 23S rRNA
CE463_RS22560	COG1841	ribosomal large subunit assembly
CE463_RS22565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CE463_RS22570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CE463_RS22575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CE463_RS22580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CE463_RS22585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CE463_RS22590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CE463_RS22595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CE463_RS22600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CE463_RS22605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CE463_RS22610	COG0255	Belongs to the universal ribosomal protein uL29 family
CE463_RS22615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CE463_RS22620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CE463_RS22625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CE463_RS22630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CE463_RS22635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CE463_RS22640	COG0089	rRNA binding
CE463_RS22645	COG0088	Forms part of the polypeptide exit tunnel
CE463_RS22650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CE463_RS22655	COG0051	transcription antitermination factor activity, RNA binding
CE463_RS22675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CE463_RS22680	COG2183	response to ionizing radiation
CE463_RS22700	COG0596	Alpha beta hydrolase
CE463_RS22705	COG1040	competence protein
CE463_RS22710	COG0316	Belongs to the HesB IscA family
CE463_RS22710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CE463_RS22715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CE463_RS22720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CE463_RS22725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CE463_RS22730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CE463_RS22735	COG4942	peptidase
CE463_RS22745	COG1609	Transcriptional regulator
CE463_RS22750	COG0800	Aldolase
CE463_RS22755	COG0129	dihydroxy-acid dehydratase activity
CE463_RS22760	COG3265	gluconokinase activity
CE463_RS22765	COG2610	gluconate transmembrane transporter activity
CE463_RS22770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CE463_RS22775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CE463_RS22785	COG0456	acetyltransferase
CE463_RS22795	COG1490	D-aminoacyl-tRNA deacylase activity
CE463_RS22800	COG1295	ribonuclease BN
CE463_RS22805	COG1217	gtp-binding protein TYPA
CE463_RS22810	COG0174	glutamine synthetase
CE463_RS22820	COG3852	Histidine kinase
CE463_RS22825	COG2204	response regulator
CE463_RS22830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CE463_RS22835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CE463_RS22845	COG3078	GTPase activator activity
CE463_RS22855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CE463_RS22865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CE463_RS22870	COG0408	coproporphyrinogen oxidase activity
CE463_RS22875	COG0009	L-threonylcarbamoyladenylate synthase
CE463_RS22885	COG0551	DNA topoisomerase type I activity
CE463_RS22890	COG2922	Belongs to the Smg family
CE463_RS22895	COG0758	DNA mediated transformation
CE463_RS22900	COG1652	LysM domain
CE463_RS22905	COG0242	peptide deformylase activity
CE463_RS22910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CE463_RS22915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CE463_RS22915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CE463_RS22920	COG0569	domain protein
CE463_RS22925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CE463_RS22950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CE463_RS22955	COG0686	Belongs to the AlaDH PNT family
CE463_RS22960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CE463_RS22960	COG0519	Catalyzes the synthesis of GMP from XMP
CE463_RS22970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CE463_RS22980	COG1012	belongs to the aldehyde dehydrogenase family
CE463_RS22990	COG2962	Rard protein
CE463_RS23000	COG1280	lysine exporter protein (LysE YggA)
CE463_RS23025	COG2116	formate transmembrane transporter activity
CE463_RS23030	COG1648	precorrin-2 dehydrogenase activity
CE463_RS23030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CE463_RS23035	COG2239	Acts as a magnesium transporter
CE463_RS23045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CE463_RS23050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CE463_RS23060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CE463_RS23070	COG0514	ATP-dependent DNA helicase (RecQ)
CE463_RS23075	COG2050	protein possibly involved in aromatic compounds catabolism
CE463_RS23095	COG2258	MOSC domain
CE463_RS23100	COG1177	transmembrane transport
CE463_RS23105	COG1176	ABC-type spermidine putrescine transport system, permease component I
CE463_RS23110	COG3842	ATPase activity
CE463_RS23130	COG0174	glutamine synthetase
CE463_RS23150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CE463_RS23155	COG0443	Heat shock 70 kDa protein
CE463_RS23170	COG0366	Alpha amylase catalytic
CE463_RS23175	COG1086	Polysaccharide biosynthesis protein
CE463_RS23180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CE463_RS23190	COG0463	Glycosyl transferase, family 2
CE463_RS23205	COG0318	PFAM AMP-dependent synthetase and ligase
CE463_RS23225	COG1083	cytidylyl-transferase
CE463_RS23235	COG2089	acid synthase
CE463_RS23260	COG5433	transposase activity
CE463_RS23270	COG4310	Domain of unknown function (DUF2172)
CE463_RS23305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CE463_RS23310	COG0745	RESPONSE REGULATOR receiver
CE463_RS23315	COG2205	protein histidine kinase activity
CE463_RS23325	COG0281	malic enzyme
CE463_RS23330	COG0702	epimerase
CE463_RS23335	COG0254	rRNA binding
CE463_RS23340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CE463_RS23350	COG1309	transcriptional regulator
CE463_RS23370	COG0129	dihydroxy-acid dehydratase activity
CE463_RS23380	COG3978	acetolactate synthase activity
CE463_RS23390	COG0606	chelatase, subunit chli
CE463_RS23400	COG1683	Conserved Protein
CE463_RS23410	COG1335	isochorismatase
CE463_RS23420	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CE463_RS23425	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CE463_RS23430	COG3639	organic phosphonate transmembrane transporter activity
CE463_RS23435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CE463_RS23440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CE463_RS23450	COG3084	Protein conserved in bacteria
CE463_RS23455	COG5001	Diguanylate cyclase
CE463_RS23455	COG3706	GGDEF domain
CE463_RS23455	COG4251	negative regulation of phosphorylation
CE463_RS23455	COG2203	Gaf domain
CE463_RS23470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CE463_RS23480	COG1561	YicC-like family, N-terminal region
CE463_RS23515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CE463_RS23530	COG1063	alcohol dehydrogenase
CE463_RS23545	COG0210	DNA helicase
CE463_RS23550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CE463_RS23555	COG2166	iron-sulfur cluster assembly
CE463_RS23560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CE463_RS23590	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CE463_RS23595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CE463_RS23600	COG1739	Uncharacterized protein family UPF0029
CE463_RS23610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CE463_RS23615	COG1024	Enoyl-CoA hydratase
CE463_RS23615	COG1250	3-hydroxyacyl-CoA dehydrogenase
CE463_RS23620	COG0183	Belongs to the thiolase family
CE463_RS23645	COG0425	Belongs to the sulfur carrier protein TusA family
CE463_RS23650	COG0251	oxidation-reduction process
CE463_RS23655	COG2885	chlorophyll binding
CE463_RS23660	COG2818	Glycosylase
CE463_RS23665	COG0752	glycyl-tRNA synthetase alpha subunit
CE463_RS23670	COG0751	glycine-tRNA ligase activity
CE463_RS23690	COG2188	Transcriptional regulator
CE463_RS23695	COG3604	Transcriptional regulator
CE463_RS23705	COG0446	pyridine nucleotide-disulphide oxidoreductase
CE463_RS23715	COG0348	domain, Protein
CE463_RS23720	COG0814	amino acid
CE463_RS23735	COG2202	Pas domain
CE463_RS23735	COG2199	diguanylate cyclase activity
CE463_RS23735	COG2200	EAL domain
CE463_RS23745	COG3385	transposase activity
CE463_RS23765	COG3328	transposase activity
CE463_RS23795	COG1609	Transcriptional regulator
CE463_RS23835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CE463_RS23860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CE463_RS23875	COG3118	belongs to the thioredoxin family
CE463_RS23880	COG0513	Belongs to the DEAD box helicase family
CE463_RS23885	COG0248	Ppx GppA phosphatase
CE463_RS23895	COG0742	ribosomal rna small subunit methyltransferase
CE463_RS23900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CE463_RS23920	COG0084	hydrolase, TatD family'
CE463_RS23925	COG0805	protein transport
CE463_RS23930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CE463_RS23940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CE463_RS23945	COG3165	ubiquinone biosynthetic process from chorismate
CE463_RS23955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CE463_RS23960	COG0402	S-adenosylhomocysteine deaminase activity
CE463_RS24000	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CE463_RS24005	COG0848	biopolymer transport protein
CE463_RS24010	COG0811	peptide transport
CE463_RS24015	COG0811	peptide transport
CE463_RS24025	COG2771	luxR family
CE463_RS24030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CE463_RS24035	COG1349	DNA-binding transcription factor activity
CE463_RS24040	COG0745	RESPONSE REGULATOR receiver
CE463_RS24055	COG4452	Inner membrane protein CreD
CE463_RS24060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CE463_RS24065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CE463_RS24070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CE463_RS24075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CE463_RS24080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CE463_RS24085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CE463_RS24090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CE463_RS24100	COG0356	it plays a direct role in the translocation of protons across the membrane
CE463_RS24105	COG3312	ion transport
CE463_RS24110	COG1475	DNA binding
CE463_RS24115	COG1192	Involved in chromosome partitioning
CE463_RS24120	COG0357	Ribosomal RNA small subunit methyltransferase G
CE463_RS24125	COG0445	tRNA wobble uridine modification
CE463_RS24130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CE463_RS24135	COG4774	siderophore transport
CE463_RS24140	COG4615	Cyclic peptide transporter
CE463_RS24145	COG1120	ATPase activity
CE463_RS24150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CE463_RS24160	COG4774	siderophore transport
CE463_RS24165	COG4607	ABC-type enterochelin transport system periplasmic component
CE463_RS24170	COG4604	ABC transporter, ATP-binding protein
CE463_RS24175	COG4605	iron ion homeostasis
CE463_RS24180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CE463_RS24185	COG1132	(ABC) transporter
CE463_RS24190	COG1132	(ABC) transporter
CE463_RS24190	COG2375	cellular response to nickel ion
CE463_RS24200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CE463_RS24210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CE463_RS24225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CE463_RS24230	COG0706	membrane insertase activity
CE463_RS24235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CE463_RS24240	COG0594	ribonuclease P activity
CE463_RS24245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CE463_RS24250	COG1126	abc transporter atp-binding protein