locus-tag	class	description
HED66_RS00005	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HED66_RS00010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HED66_RS00015	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HED66_RS00020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HED66_RS00025	COG1185	polyribonucleotide nucleotidyltransferase activity
HED66_RS00030	COG2211	Major facilitator Superfamily
HED66_RS00035	COG3706	GGDEF domain
HED66_RS00040	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HED66_RS00045	COG1422	Protein of unknown function (DUF1090)
HED66_RS00050	COG0114	fumarate hydratase activity
HED66_RS00120	COG0312	modulator of DNA gyrase
HED66_RS00135	COG4974	Belongs to the 'phage' integrase family
HED66_RS00140	COG3706	GGDEF domain
HED66_RS00145	COG1970	mechanosensitive ion channel activity
HED66_RS00155	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HED66_RS00170	COG3545	Serine hydrolase
HED66_RS00175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HED66_RS00180	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HED66_RS00185	COG0321	lipoyl(octanoyl) transferase activity
HED66_RS00190	COG2921	Belongs to the UPF0250 family
HED66_RS00195	COG1686	Belongs to the peptidase S11 family
HED66_RS00200	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HED66_RS00205	COG2951	lytic endotransglycosylase activity
HED66_RS00210	COG0772	Belongs to the SEDS family
HED66_RS00215	COG0768	penicillin binding
HED66_RS00220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HED66_RS00225	COG0799	negative regulation of ribosome biogenesis
HED66_RS00230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HED66_RS00250	COG0495	leucyl-tRNA aminoacylation
HED66_RS00255	COG2888	peptidyl-tyrosine sulfation
HED66_RS00260	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HED66_RS00265	COG4535	Mg2 and Co2 transporter CorC
HED66_RS00270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HED66_RS00275	COG1702	phosphate starvation-inducible protein PhoH
HED66_RS00280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HED66_RS00285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HED66_RS00295	COG3706	GGDEF domain
HED66_RS00310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HED66_RS00330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HED66_RS00340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HED66_RS00350	COG0516	GMP reductase activity
HED66_RS00360	COG0642	Histidine kinase
HED66_RS00365	COG0745	RESPONSE REGULATOR receiver
HED66_RS00385	COG1022	Amp-dependent synthetase and ligase
HED66_RS00400	COG3214	Protein conserved in bacteria
HED66_RS00410	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HED66_RS00415	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HED66_RS00420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HED66_RS00425	COG1053	succinate dehydrogenase
HED66_RS00435	COG0584	glycerophosphoryl diester phosphodiesterase
HED66_RS00440	COG1511	domain protein
HED66_RS00440	COG3264	Mechanosensitive ion channel
HED66_RS00450	COG0739	heme binding
HED66_RS00465	COG0583	DNA-binding transcription factor activity
HED66_RS00480	COG0840	transmembrane signaling receptor activity
HED66_RS00485	COG0583	DNA-binding transcription factor activity
HED66_RS00490	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HED66_RS00520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HED66_RS00525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HED66_RS00535	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HED66_RS00540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HED66_RS00545	COG0546	phosphoglycolate phosphatase activity
HED66_RS00550	COG0180	Tryptophanyl-tRNA synthetase
HED66_RS00565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HED66_RS00575	COG1012	belongs to the aldehyde dehydrogenase family
HED66_RS00600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HED66_RS00610	COG0674	pyruvate-flavodoxin oxidoreductase activity
HED66_RS00610	COG1013	pyruvate-flavodoxin oxidoreductase activity
HED66_RS00610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HED66_RS00610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED66_RS00620	COG0488	(ABC) transporter
HED66_RS00635	COG0366	Alpha amylase catalytic
HED66_RS00655	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HED66_RS00665	COG0490	domain, Protein
HED66_RS00665	COG0471	metal ion transport
HED66_RS00710	COG0012	GTP binding
HED66_RS00715	COG0193	aminoacyl-tRNA hydrolase activity
HED66_RS00720	COG0737	Belongs to the 5'-nucleotidase family
HED66_RS00725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HED66_RS00735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HED66_RS00740	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HED66_RS00745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HED66_RS00750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HED66_RS00755	COG2890	protein-(glutamine-N5) methyltransferase activity
HED66_RS00765	COG2912	Transglutaminase-like superfamily
HED66_RS00785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HED66_RS00800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HED66_RS00805	COG1115	amino acid carrier protein
HED66_RS00820	COG0714	Associated with various cellular activities
HED66_RS00840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HED66_RS00845	COG1678	Uncharacterized ACR, COG1678
HED66_RS00855	COG0189	ligase activity
HED66_RS00860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HED66_RS00870	COG3091	SprT-like family
HED66_RS00880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HED66_RS00895	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HED66_RS00900	COG0739	heme binding
HED66_RS00905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HED66_RS00920	COG0463	Glycosyl transferase, family 2
HED66_RS00935	COG2989	Protein conserved in bacteria
HED66_RS00940	COG3108	Peptidase M15
HED66_RS00950	COG2860	membrane
HED66_RS00960	COG1196	nuclear chromosome segregation
HED66_RS00965	COG3115	cell septum assembly
HED66_RS00970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HED66_RS00980	COG1328	CTP reductase activity
HED66_RS00985	COG0602	queuosine metabolic process
HED66_RS01010	COG1566	PFAM secretion protein HlyD family protein
HED66_RS01015	COG1846	Transcriptional regulator
HED66_RS01030	COG0281	malic enzyme
HED66_RS01035	COG3290	protein histidine kinase activity
HED66_RS01050	COG0667	Aldo Keto reductase
HED66_RS01060	COG0697	spore germination
HED66_RS01070	COG1012	belongs to the aldehyde dehydrogenase family
HED66_RS01075	COG3284	Transcriptional regulator
HED66_RS01080	COG3706	GGDEF domain
HED66_RS01085	COG0346	lactoylglutathione lyase activity
HED66_RS01090	COG0745	RESPONSE REGULATOR receiver
HED66_RS01095	COG5002	protein histidine kinase activity
HED66_RS01115	COG1940	carbohydrate kinase activity
HED66_RS01120	COG3142	Participates in the control of copper homeostasis
HED66_RS01125	COG0545	Peptidyl-prolyl cis-trans isomerase
HED66_RS01130	COG1131	(ABC) transporter
HED66_RS01170	COG0019	diaminopimelate decarboxylase activity
HED66_RS01175	COG1115	amino acid carrier protein
HED66_RS01180	COG0095	Lipoate-protein ligase
HED66_RS01185	COG2233	PERMEase
HED66_RS01200	COG0534	Mate efflux family protein
HED66_RS01205	COG2207	Transcriptional regulator
HED66_RS01210	COG0281	malic enzyme
HED66_RS01240	COG0733	neurotransmitter:sodium symporter activity
HED66_RS01245	COG1752	Esterase of the alpha-beta hydrolase superfamily
HED66_RS01250	COG3706	GGDEF domain
HED66_RS01255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HED66_RS01260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HED66_RS01270	COG1032	radical SAM domain protein
HED66_RS01275	COG2801	Transposase and inactivated derivatives
HED66_RS01335	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HED66_RS01340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HED66_RS01345	COG0739	heme binding
HED66_RS01345	COG0741	lytic transglycosylase activity
HED66_RS01345	COG1196	nuclear chromosome segregation
HED66_RS01350	COG0366	Alpha amylase catalytic
HED66_RS01370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HED66_RS01380	COG0788	formyltetrahydrofolate deformylase activity
HED66_RS01385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HED66_RS01395	COG3118	belongs to the thioredoxin family
HED66_RS01400	COG2091	lysine biosynthetic process via aminoadipic acid
HED66_RS01405	COG0791	NLP P60 protein
HED66_RS01410	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HED66_RS01425	COG1376	ErfK ybiS ycfS ynhG family protein
HED66_RS01425	COG1388	LysM domain
HED66_RS01485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HED66_RS01495	COG1960	acyl-CoA dehydrogenase activity
HED66_RS01500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HED66_RS01510	COG0469	pyruvate kinase activity
HED66_RS01515	COG1737	Transcriptional regulator
HED66_RS01525	COG3290	protein histidine kinase activity
HED66_RS01530	COG0745	RESPONSE REGULATOR receiver
HED66_RS01535	COG2274	protein secretion by the type I secretion system
HED66_RS01545	COG2274	protein secretion by the type I secretion system
HED66_RS01555	COG2994	toxin metabolic process
HED66_RS01560	COG1073	alpha beta
HED66_RS01560	COG3064	Membrane
HED66_RS01560	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HED66_RS01575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HED66_RS01595	COG1342	Belongs to the UPF0251 family
HED66_RS01600	COG0640	Transcriptional regulator
HED66_RS01610	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HED66_RS01620	COG1677	Flagellar hook-basal body complex protein FliE
HED66_RS01630	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HED66_RS01685	COG1684	flagellar biosynthetic protein fliR
HED66_RS01695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HED66_RS01720	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HED66_RS01725	COG0643	Histidine kinase
HED66_RS01725	COG2198	Histidine kinase
HED66_RS01725	COG0784	Response regulator, receiver
HED66_RS01730	COG2201	protein-glutamate methylesterase activity
HED66_RS01735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HED66_RS01740	COG1360	Flagellar Motor Protein
HED66_RS01745	COG1192	Involved in chromosome partitioning
HED66_RS01755	COG0835	chemotaxis
HED66_RS01775	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HED66_RS01780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HED66_RS01785	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HED66_RS01790	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HED66_RS01795	COG1138	Cytochrome C-type biogenesis protein
HED66_RS01800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HED66_RS01810	COG3088	subunit of a heme lyase
HED66_RS01810	COG4235	cytochrome complex assembly
HED66_RS01825	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HED66_RS01830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HED66_RS01830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HED66_RS01845	COG0259	pyridoxamine-phosphate oxidase activity
HED66_RS01850	COG0625	glutathione transferase activity
HED66_RS01860	COG3153	acetyltransferase
HED66_RS01870	COG2850	peptidyl-arginine hydroxylation
HED66_RS01875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HED66_RS01880	COG2915	High frequency lysogenization protein hflD homolog
HED66_RS01885	COG0482	sulfurtransferase activity
HED66_RS01895	COG1187	pseudouridine synthase activity
HED66_RS01905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HED66_RS01915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HED66_RS01915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HED66_RS01915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HED66_RS01960	COG0783	Belongs to the Dps family
HED66_RS01970	COG1988	membrane-bound metal-dependent
HED66_RS01975	COG0326	Molecular chaperone. Has ATPase activity
HED66_RS01980	COG0159	tryptophan synthase activity
HED66_RS01985	COG0133	tryptophan synthase activity
HED66_RS01990	COG0135	phosphoribosylanthranilate isomerase activity
HED66_RS01990	COG0134	indole-3-glycerol-phosphate synthase activity
HED66_RS01995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HED66_RS02000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HED66_RS02000	COG0512	Glutamine amidotransferase of anthranilate synthase
HED66_RS02005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HED66_RS02015	COG0009	L-threonylcarbamoyladenylate synthase
HED66_RS02025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HED66_RS02035	COG1946	Acyl-CoA thioesterase
HED66_RS02050	COG1309	transcriptional regulator
HED66_RS02055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HED66_RS02060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HED66_RS02080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HED66_RS02085	COG2030	dehydratase
HED66_RS02100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HED66_RS02105	COG2089	acid synthase
HED66_RS02150	COG1215	transferase activity, transferring glycosyl groups
HED66_RS02155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HED66_RS02160	COG1091	dTDP-4-dehydrorhamnose reductase activity
HED66_RS02175	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HED66_RS02185	COG3132	Protein of unknown function, DUF480
HED66_RS02225	COG1278	Cold shock
HED66_RS02250	COG4166	transmembrane transport
HED66_RS02255	COG0697	spore germination
HED66_RS02280	COG4166	transmembrane transport
HED66_RS02285	COG0622	Phosphoesterase
HED66_RS02305	COG0835	chemotaxis
HED66_RS02305	COG0784	Response regulator, receiver
HED66_RS02310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HED66_RS02315	COG1815	bacterial-type flagellum-dependent cell motility
HED66_RS02335	COG4787	bacterial-type flagellum-dependent cell motility
HED66_RS02345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HED66_RS02350	COG1706	bacterial-type flagellum-dependent cell motility
HED66_RS02355	COG3951	Flagellar rod assembly protein muramidase FlgJ
HED66_RS02355	COG1705	Flagellar rod assembly protein muramidase FlgJ
HED66_RS02370	COG2239	Acts as a magnesium transporter
HED66_RS02375	COG0248	Ppx GppA phosphatase
HED66_RS02380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HED66_RS02400	COG3852	Histidine kinase
HED66_RS02410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HED66_RS02415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HED66_RS02420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HED66_RS02425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HED66_RS02445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HED66_RS02455	COG0590	tRNA wobble adenosine to inosine editing
HED66_RS02460	COG0573	inorganic phosphate transmembrane transporter activity
HED66_RS02465	COG0581	inorganic phosphate transmembrane transporter activity
HED66_RS02475	COG0704	Plays a role in the regulation of phosphate uptake
HED66_RS02480	COG1253	flavin adenine dinucleotide binding
HED66_RS02495	COG0531	amino acid
HED66_RS02505	COG1126	abc transporter atp-binding protein
HED66_RS02510	COG0765	amino acid transport
HED66_RS02515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED66_RS02520	COG3706	GGDEF domain
HED66_RS02525	COG2271	Major facilitator Superfamily
HED66_RS02530	COG3851	Histidine kinase
HED66_RS02540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HED66_RS02560	COG1785	Belongs to the alkaline phosphatase family
HED66_RS02565	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HED66_RS02570	COG0123	including yeast histone deacetylase and acetoin utilization protein
HED66_RS02580	COG1199	ATP-dependent helicase activity
HED66_RS02595	COG1448	Aminotransferase
HED66_RS02600	COG0433	COG0433 Predicted ATPase
HED66_RS02615	COG0658	competence protein
HED66_RS02615	COG2333	competence protein COMEC
HED66_RS02620	COG1132	(ABC) transporter
HED66_RS02625	COG1663	tetraacyldisaccharide 4'-kinase activity
HED66_RS02630	COG2835	tetraacyldisaccharide 4'-kinase activity
HED66_RS02635	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HED66_RS02640	COG2197	response regulator
HED66_RS02645	COG0322	excinuclease ABC activity
HED66_RS02825	COG4695	Portal protein
HED66_RS02925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HED66_RS02945	COG4974	Belongs to the 'phage' integrase family
HED66_RS02985	COG2261	transglycosylase associated protein
HED66_RS02990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HED66_RS03000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HED66_RS03025	COG2203	Gaf domain
HED66_RS03025	COG2199	diguanylate cyclase activity
HED66_RS03055	COG2119	membrane
HED66_RS03100	COG2205	protein histidine kinase activity
HED66_RS03100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED66_RS03110	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HED66_RS03115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HED66_RS03120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HED66_RS03125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HED66_RS03130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HED66_RS03135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HED66_RS03150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HED66_RS03155	COG0505	Belongs to the CarA family
HED66_RS03160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HED66_RS03165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HED66_RS03190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HED66_RS03195	COG0513	Belongs to the DEAD box helicase family
HED66_RS03205	COG4104	PAAR repeat-containing protein
HED66_RS03220	COG0789	Transcriptional regulator
HED66_RS03235	COG0493	'glutamate synthase
HED66_RS03240	COG0069	glutamate synthase activity
HED66_RS03240	COG0067	glutamate synthase
HED66_RS03240	COG0070	glutamate synthase
HED66_RS03245	COG1242	4 iron, 4 sulfur cluster binding
HED66_RS03320	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HED66_RS03325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HED66_RS03325	COG0574	Belongs to the PEP-utilizing enzyme family
HED66_RS03365	COG1464	Belongs to the NlpA lipoprotein family
HED66_RS03370	COG0671	phosphoesterase, PA-phosphatase related
HED66_RS03375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HED66_RS03380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HED66_RS03390	COG0101	tRNA pseudouridine synthase activity
HED66_RS03395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HED66_RS03400	COG0285	dihydrofolate synthase activity
HED66_RS03405	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HED66_RS03410	COG2920	part of a sulfur-relay system
HED66_RS03415	COG1289	transmembrane transporter activity
HED66_RS03420	COG0670	Belongs to the BI1 family
HED66_RS03435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HED66_RS03440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HED66_RS03445	COG0745	RESPONSE REGULATOR receiver
HED66_RS03450	COG5002	protein histidine kinase activity
HED66_RS03455	COG0840	transmembrane signaling receptor activity
HED66_RS03460	COG5001	Diguanylate cyclase
HED66_RS03465	COG0564	pseudouridine synthase activity
HED66_RS03480	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HED66_RS03490	COG0625	glutathione transferase activity
HED66_RS03500	COG0367	asparagine synthase
HED66_RS03510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HED66_RS03510	COG4651	solute:proton antiporter activity
HED66_RS03515	COG0647	UMP catabolic process
HED66_RS03525	COG1902	pentaerythritol trinitrate reductase activity
HED66_RS03530	COG1253	flavin adenine dinucleotide binding
HED66_RS03540	COG0247	lactate metabolic process
HED66_RS03540	COG0277	FAD linked oxidase domain protein
HED66_RS03550	COG2050	protein possibly involved in aromatic compounds catabolism
HED66_RS03555	COG0513	Belongs to the DEAD box helicase family
HED66_RS03570	COG2056	Na+-H+ antiporter family
HED66_RS03575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HED66_RS03590	COG0346	lactoylglutathione lyase activity
HED66_RS03595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HED66_RS03600	COG4660	Part of a membrane complex involved in electron transport
HED66_RS03605	COG4659	FMN binding
HED66_RS03610	COG4658	electron transport chain
HED66_RS03620	COG2878	Part of a membrane complex involved in electron transport
HED66_RS03625	COG4657	Part of a membrane complex involved in electron transport
HED66_RS03630	COG0697	spore germination
HED66_RS03645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HED66_RS03650	COG1288	antiporter activity
HED66_RS03655	COG0436	Aminotransferase
HED66_RS03665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HED66_RS03670	COG2027	D-alanyl-D-alanine carboxypeptidase
HED66_RS03675	COG1061	Type III restriction enzyme res subunit
HED66_RS03680	COG1566	PFAM secretion protein HlyD family protein
HED66_RS03690	COG1966	Carbon starvation protein
HED66_RS03695	COG3279	Response regulator of the LytR AlgR family
HED66_RS03700	COG3275	phosphorelay sensor kinase activity
HED66_RS03705	COG2199	diguanylate cyclase activity
HED66_RS03705	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HED66_RS03710	COG1012	belongs to the aldehyde dehydrogenase family
HED66_RS03710	COG1454	alcohol dehydrogenase
HED66_RS03720	COG2095	MarC family integral membrane protein
HED66_RS03730	COG0601	transmembrane transport
HED66_RS03735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED66_RS03740	COG0444	Belongs to the ABC transporter superfamily
HED66_RS03750	COG0861	Integral membrane protein TerC family
HED66_RS03755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HED66_RS03765	COG1301	dicarboxylic acid transport
HED66_RS03780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HED66_RS03795	COG0537	adenosine 5'-monophosphoramidase activity
HED66_RS03830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HED66_RS03835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HED66_RS03855	COG1007	ATP synthesis coupled electron transport
HED66_RS03860	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED66_RS03870	COG0713	ATP synthesis coupled electron transport
HED66_RS03875	COG0839	Belongs to the complex I subunit 6 family
HED66_RS03880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED66_RS03885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HED66_RS03890	COG1034	ATP synthesis coupled electron transport
HED66_RS03905	COG0649	NAD binding
HED66_RS03905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED66_RS03910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED66_RS03915	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED66_RS03930	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HED66_RS03945	COG4597	amino acid ABC transporter
HED66_RS03950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED66_RS03955	COG0765	amino acid transport
HED66_RS03960	COG1126	abc transporter atp-binding protein
HED66_RS03970	COG0724	RNA recognition motif
HED66_RS03975	COG4989	oxidoreductase activity
HED66_RS04000	COG3437	response regulator, receiver
HED66_RS04005	COG0583	DNA-binding transcription factor activity
HED66_RS04015	COG3300	MHYT domain
HED66_RS04015	COG5001	Diguanylate cyclase
HED66_RS04035	COG2814	Major facilitator Superfamily
HED66_RS04040	COG0583	DNA-binding transcription factor activity
HED66_RS04050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HED66_RS04055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HED66_RS04060	COG0539	negative regulation of cytoplasmic translation
HED66_RS04065	COG0776	regulation of translation
HED66_RS04075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HED66_RS04080	COG0284	orotidine-5'-phosphate decarboxylase activity
HED66_RS04095	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HED66_RS04100	COG0602	queuosine metabolic process
HED66_RS04105	COG3530	Putative quorum-sensing-regulated virulence factor
HED66_RS04110	COG2096	Adenosyltransferase
HED66_RS04115	COG2916	Histone family protein nucleoid-structuring protein H-NS
HED66_RS04120	COG1757	Na H antiporter
HED66_RS04125	COG1435	thymidine kinase activity
HED66_RS04145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HED66_RS04150	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HED66_RS04155	COG0437	4 iron, 4 sulfur cluster binding
HED66_RS04160	COG5557	Pfam Polysulphide reductase, NrfD
HED66_RS04165	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HED66_RS04170	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HED66_RS04175	COG1773	rubredoxin
HED66_RS04185	COG0601	transmembrane transport
HED66_RS04190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED66_RS04200	COG1124	(ABC) transporter
HED66_RS04205	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HED66_RS04210	COG0375	protein maturation
HED66_RS04215	COG0309	Hydrogenase expression formation protein (HypE)
HED66_RS04225	COG0298	carbon dioxide binding
HED66_RS04230	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HED66_RS04240	COG1921	L-seryl-tRNASec selenium transferase activity
HED66_RS04250	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HED66_RS04260	COG3260	NADH ubiquinone oxidoreductase 20
HED66_RS04265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HED66_RS04270	COG3261	NADH dehydrogenase
HED66_RS04270	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HED66_RS04275	COG0650	Formate hydrogenlyase subunit 4
HED66_RS04280	COG0651	ATP synthesis coupled electron transport
HED66_RS04285	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HED66_RS04290	COG3158	transport of potassium into the cell
HED66_RS04305	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HED66_RS04330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HED66_RS04335	COG0326	Molecular chaperone. Has ATPase activity
HED66_RS04345	COG0563	adenylate kinase activity
HED66_RS04350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HED66_RS04355	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HED66_RS04360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HED66_RS04365	COG0840	transmembrane signaling receptor activity
HED66_RS04380	COG3300	MHYT domain
HED66_RS04380	COG5001	Diguanylate cyclase
HED66_RS04385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HED66_RS04405	COG1021	2,3-dihydroxybenzoate-AMP ligase
HED66_RS04410	COG3433	isochorismatase activity
HED66_RS04410	COG1535	isochorismatase
HED66_RS04415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED66_RS04420	COG1028	Short-chain dehydrogenase reductase Sdr
HED66_RS04430	COG1028	Short-chain dehydrogenase reductase Sdr
HED66_RS04430	COG3321	synthase
HED66_RS04430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED66_RS04430	COG0318	PFAM AMP-dependent synthetase and ligase
HED66_RS04430	COG0300	oxidoreductase activity
HED66_RS04445	COG2977	Belongs to the P-Pant transferase superfamily
HED66_RS04450	COG1120	ATPase activity
HED66_RS04455	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED66_RS04460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED66_RS04465	COG4771	TonB-dependent receptor
HED66_RS04505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HED66_RS04510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HED66_RS04515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HED66_RS04530	COG1570	exodeoxyribonuclease VII activity
HED66_RS04535	COG3038	cytochrome b561
HED66_RS04555	COG0516	GMP reductase activity
HED66_RS04555	COG0517	IMP dehydrogenase activity
HED66_RS04560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HED66_RS04560	COG0519	Catalyzes the synthesis of GMP from XMP
HED66_RS04610	COG2062	phosphohistidine phosphatase, SixA
HED66_RS04620	COG0697	spore germination
HED66_RS04625	COG4166	transmembrane transport
HED66_RS04630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HED66_RS04635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HED66_RS04645	COG4591	ABC-type transport system involved in lipoprotein release permease component
HED66_RS04650	COG1136	(ABC) transporter
HED66_RS04655	COG4591	ABC-type transport system involved in lipoprotein release permease component
HED66_RS04660	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HED66_RS04670	COG0544	peptidyl-prolyl cis-trans isomerase activity
HED66_RS04675	COG0740	serine-type endopeptidase activity
HED66_RS04680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HED66_RS04685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HED66_RS04690	COG0776	regulation of translation
HED66_RS04695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HED66_RS04700	COG0488	(ABC) transporter
HED66_RS04710	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HED66_RS04715	COG0517	IMP dehydrogenase activity
HED66_RS04725	COG1250	3-hydroxyacyl-CoA dehydrogenase
HED66_RS04725	COG1024	Enoyl-CoA hydratase
HED66_RS04730	COG1115	amino acid carrier protein
HED66_RS04735	COG0456	acetyltransferase
HED66_RS04740	COG3228	Belongs to the MtfA family
HED66_RS04745	COG1584	GPR1 FUN34 yaaH family protein
HED66_RS04775	COG1024	Enoyl-CoA hydratase
HED66_RS04780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HED66_RS04785	COG1960	acyl-CoA dehydrogenase activity
HED66_RS04795	COG1960	acyl-CoA dehydrogenase activity
HED66_RS04800	COG1024	Enoyl-CoA hydratase
HED66_RS04805	COG1024	Enoyl-CoA hydratase
HED66_RS04815	COG1028	Short-chain dehydrogenase reductase Sdr
HED66_RS04825	COG0730	response to heat
HED66_RS04880	COG2823	Periplasmic or secreted lipoprotein
HED66_RS04885	COG4251	negative regulation of phosphorylation
HED66_RS04885	COG2203	Gaf domain
HED66_RS04885	COG3706	GGDEF domain
HED66_RS04885	COG5001	Diguanylate cyclase
HED66_RS04890	COG1172	Belongs to the binding-protein-dependent transport system permease family
HED66_RS04895	COG1172	Belongs to the binding-protein-dependent transport system permease family
HED66_RS04900	COG1129	ABC transporter
HED66_RS04905	COG1879	ABC-type sugar transport system periplasmic component
HED66_RS04910	COG0583	DNA-binding transcription factor activity
HED66_RS04915	COG2723	6-phospho-beta-galactosidase activity
HED66_RS04925	COG0583	DNA-binding transcription factor activity
HED66_RS04930	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HED66_RS04935	COG0673	inositol 2-dehydrogenase activity
HED66_RS04940	COG0583	DNA-binding transcription factor activity
HED66_RS04950	COG1560	Kdo2-lipid A biosynthetic process
HED66_RS04955	COG1560	Kdo2-lipid A biosynthetic process
HED66_RS04970	COG2203	Gaf domain
HED66_RS04970	COG2199	diguanylate cyclase activity
HED66_RS04980	COG0417	DNA replication proofreading
HED66_RS05025	COG0307	riboflavin synthase, alpha
HED66_RS05040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HED66_RS05045	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HED66_RS05050	COG0697	spore germination
HED66_RS05055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HED66_RS05100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HED66_RS05105	COG3099	Belongs to the UPF0263 family
HED66_RS05110	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HED66_RS05115	COG2894	cell division
HED66_RS05120	COG0850	regulation of cytokinetic process
HED66_RS05125	COG3100	YcgL domain-containing protein
HED66_RS05130	COG2951	lytic endotransglycosylase activity
HED66_RS05135	COG1760	l-serine dehydratase
HED66_RS05140	COG1760	l-serine dehydratase
HED66_RS05145	COG3123	guanosine phosphorylase activity
HED66_RS05165	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HED66_RS05170	COG2067	long-chain fatty acid transport protein
HED66_RS05175	COG2067	long-chain fatty acid transport protein
HED66_RS05215	COG0714	Associated with various cellular activities
HED66_RS05220	COG0183	Belongs to the thiolase family
HED66_RS05225	COG1024	Enoyl-CoA hydratase
HED66_RS05225	COG1250	3-hydroxyacyl-CoA dehydrogenase
HED66_RS05230	COG2824	Alkylphosphonate utilization operon protein PhnA
HED66_RS05260	COG3706	GGDEF domain
HED66_RS05265	COG2840	Smr protein MutS2
HED66_RS05270	COG2890	protein-(glutamine-N5) methyltransferase activity
HED66_RS05275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HED66_RS05285	COG0513	Belongs to the DEAD box helicase family
HED66_RS05290	COG5654	RES domain protein
HED66_RS05300	COG0814	amino acid
HED66_RS05305	COG1609	Transcriptional regulator
HED66_RS05310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HED66_RS05310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HED66_RS05315	COG1105	Belongs to the carbohydrate kinase PfkB family
HED66_RS05320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HED66_RS05320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HED66_RS05320	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HED66_RS05325	COG3313	Fe-S protein
HED66_RS05330	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HED66_RS05335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HED66_RS05340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HED66_RS05345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HED66_RS05355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HED66_RS05380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HED66_RS05385	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HED66_RS05390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HED66_RS05395	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HED66_RS05400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HED66_RS05405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HED66_RS05405	COG0072	phenylalanine-tRNA ligase activity
HED66_RS05410	COG0776	regulation of translation
HED66_RS05440	COG2199	diguanylate cyclase activity
HED66_RS05445	COG1609	Transcriptional regulator
HED66_RS05450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HED66_RS05455	COG1879	ABC-type sugar transport system periplasmic component
HED66_RS05460	COG1172	Belongs to the binding-protein-dependent transport system permease family
HED66_RS05465	COG1129	ABC transporter
HED66_RS05470	COG1869	D-ribose catabolic process
HED66_RS05475	COG0625	glutathione transferase activity
HED66_RS05490	COG0037	tRNA processing
HED66_RS05495	COG0589	response to stress
HED66_RS05500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HED66_RS05515	COG2217	Heavy metal translocating P-type atpase
HED66_RS05525	COG2010	Cytochrome c
HED66_RS05540	COG3278	Belongs to the heme-copper respiratory oxidase family
HED66_RS05550	COG1956	GAF domain-containing protein
HED66_RS05555	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HED66_RS05565	COG0308	aminopeptidase N
HED66_RS05575	COG2902	Dehydrogenase
HED66_RS05580	COG0167	dihydroorotate dehydrogenase activity
HED66_RS05590	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HED66_RS05590	COG0116	Belongs to the methyltransferase superfamily
HED66_RS05615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HED66_RS05620	COG1067	ATP-dependent peptidase activity
HED66_RS05630	COG3141	response to X-ray
HED66_RS05640	COG4221	oxidoreductase activity
HED66_RS05685	COG0372	Belongs to the citrate synthase family
HED66_RS05690	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HED66_RS05700	COG2995	paraquat-inducible protein a
HED66_RS05705	COG3008	intermembrane lipid transfer
HED66_RS05710	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HED66_RS05710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HED66_RS05725	COG0084	hydrolase, TatD family'
HED66_RS05730	COG0470	DNA polymerase III
HED66_RS05735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HED66_RS05740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HED66_RS05745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HED66_RS05750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HED66_RS05755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HED66_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
HED66_RS05770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HED66_RS05775	COG0416	fatty acid biosynthetic process
HED66_RS05780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HED66_RS05785	COG1399	metal-binding, possibly nucleic acid-binding protein
HED66_RS05790	COG0424	maF-like protein
HED66_RS05795	COG0546	phosphoglycolate phosphatase activity
HED66_RS05805	COG1530	ribonuclease E activity
HED66_RS05810	COG0306	phosphate transporter
HED66_RS05815	COG0717	Belongs to the dCTP deaminase family
HED66_RS05820	COG0572	uridine kinase
HED66_RS05825	COG0489	protein tyrosine kinase activity
HED66_RS05830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HED66_RS05830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HED66_RS05835	COG0625	glutathione transferase activity
HED66_RS05840	COG1254	Belongs to the acylphosphatase family
HED66_RS05845	COG0840	transmembrane signaling receptor activity
HED66_RS05850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HED66_RS05865	COG0709	Synthesizes selenophosphate from selenide and ATP
HED66_RS05870	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HED66_RS05875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HED66_RS05890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HED66_RS05900	COG1643	Atp-dependent helicase
HED66_RS05905	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HED66_RS05905	COG0617	tRNA 3'-terminal CCA addition
HED66_RS05905	COG0517	IMP dehydrogenase activity
HED66_RS05920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HED66_RS05925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HED66_RS05930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HED66_RS05935	COG2832	Protein of unknown function (DUF454)
HED66_RS05940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HED66_RS05960	COG0318	PFAM AMP-dependent synthetase and ligase
HED66_RS05965	COG2267	carboxylic ester hydrolase activity
HED66_RS05975	COG1214	PFAM Peptidase M22, glycoprotease
HED66_RS05980	COG1199	ATP-dependent helicase activity
HED66_RS05990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HED66_RS05995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HED66_RS06000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HED66_RS06005	COG0131	Imidazoleglycerol-phosphate dehydratase
HED66_RS06005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HED66_RS06010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HED66_RS06015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HED66_RS06020	COG3437	response regulator, receiver
HED66_RS06030	COG2198	Histidine kinase
HED66_RS06030	COG2205	protein histidine kinase activity
HED66_RS06030	COG0784	Response regulator, receiver
HED66_RS06035	COG0107	imidazoleglycerol-phosphate synthase activity
HED66_RS06040	COG0140	phosphoribosyl-ATP diphosphatase activity
HED66_RS06040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HED66_RS06050	COG2378	regulation of single-species biofilm formation
HED66_RS06055	COG0318	PFAM AMP-dependent synthetase and ligase
HED66_RS06060	COG1288	antiporter activity
HED66_RS06070	COG3134	Outer membrane lipoprotein
HED66_RS06085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED66_RS06105	COG4681	YaeQ
HED66_RS06140	COG0242	peptide deformylase activity
HED66_RS06165	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HED66_RS06170	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HED66_RS06180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HED66_RS06185	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HED66_RS06195	COG0205	6-phosphofructokinase activity
HED66_RS06200	COG1473	amidohydrolase
HED66_RS06205	COG1011	Hydrolase
HED66_RS06210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HED66_RS06270	COG3593	DNA synthesis involved in DNA repair
HED66_RS06285	COG0583	DNA-binding transcription factor activity
HED66_RS06290	COG0730	response to heat
HED66_RS06305	COG1181	Belongs to the D-alanine--D-alanine ligase family
HED66_RS06315	COG0386	Belongs to the glutathione peroxidase family
HED66_RS06320	COG0513	Belongs to the DEAD box helicase family
HED66_RS06335	COG1742	UPF0060 membrane protein
HED66_RS06370	COG2329	Antibiotic biosynthesis monooxygenase
HED66_RS06375	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HED66_RS06395	COG3243	poly(R)-hydroxyalkanoic acid synthase
HED66_RS06405	COG2501	S4 domain
HED66_RS06415	COG1132	(ABC) transporter
HED66_RS06420	COG1132	(ABC) transporter
HED66_RS06430	COG3118	belongs to the thioredoxin family
HED66_RS06435	COG0471	metal ion transport
HED66_RS06440	COG0058	SHG alpha-glucan phosphorylase activity
HED66_RS06475	COG0814	amino acid
HED66_RS06480	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HED66_RS06485	COG0514	ATP-dependent DNA helicase (RecQ)
HED66_RS06490	COG2766	serine protein kinase
HED66_RS06500	COG2719	SpoVR family
HED66_RS06505	COG2186	Transcriptional regulator
HED66_RS06510	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HED66_RS06520	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HED66_RS06525	COG0586	Pfam SNARE associated Golgi protein
HED66_RS06535	COG0556	nucleotide-excision repair
HED66_RS06545	COG2985	domain, Protein
HED66_RS06545	COG0569	domain protein
HED66_RS06550	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HED66_RS06570	COG4565	transcriptional regulatory protein
HED66_RS06575	COG3290	protein histidine kinase activity
HED66_RS06580	COG1846	Transcriptional regulator
HED66_RS06580	COG1940	carbohydrate kinase activity
HED66_RS06585	COG0840	transmembrane signaling receptor activity
HED66_RS06590	COG3012	SEC-C Motif Domain Protein
HED66_RS06595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HED66_RS06600	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HED66_RS06605	COG0247	lactate metabolic process
HED66_RS06615	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HED66_RS06620	COG0437	4 iron, 4 sulfur cluster binding
HED66_RS06625	COG3301	Polysulphide reductase, NrfD
HED66_RS06640	COG4235	cytochrome complex assembly
HED66_RS06640	COG3088	subunit of a heme lyase
HED66_RS06655	COG3033	Beta-eliminating lyase
HED66_RS06665	COG3046	protein related to deoxyribodipyrimidine photolyase
HED66_RS06670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HED66_RS06695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HED66_RS06700	COG0583	DNA-binding transcription factor activity
HED66_RS06710	COG4774	siderophore transport
HED66_RS06715	COG2207	Transcriptional regulator
HED66_RS06715	COG3708	Transcriptional regulator
HED66_RS06725	COG0583	DNA-binding transcription factor activity
HED66_RS06730	COG2910	NAD(P)H-binding
HED66_RS06745	COG0612	Peptidase, M16
HED66_RS06750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HED66_RS06755	COG1944	ATP diphosphatase activity
HED66_RS06760	COG2116	formate transmembrane transporter activity
HED66_RS06765	COG1882	Formate acetyltransferase
HED66_RS06770	COG2983	Belongs to the UPF0260 family
HED66_RS06785	COG0045	succinate-CoA ligase (ADP-forming) activity
HED66_RS06790	COG0508	dehydrogenase complex catalyzes the overall conversion of
HED66_RS06795	COG0567	Dehydrogenase, E1 component
HED66_RS06805	COG1053	succinate dehydrogenase
HED66_RS06810	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HED66_RS06835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HED66_RS06840	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HED66_RS06840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HED66_RS06850	COG3069	C4-dicarboxylate transmembrane transporter activity
HED66_RS06865	COG1451	nucleotide metabolic process
HED66_RS06880	COG0254	rRNA binding
HED66_RS06885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HED66_RS06895	COG1172	Belongs to the binding-protein-dependent transport system permease family
HED66_RS06900	COG1129	ABC transporter
HED66_RS06905	COG1879	ABC-type sugar transport system periplasmic component
HED66_RS06910	COG1069	ribulokinase activity
HED66_RS06920	COG2160	L-arabinose isomerase activity
HED66_RS06925	COG0583	DNA-binding transcription factor activity
HED66_RS06930	COG0436	Aminotransferase
HED66_RS06935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HED66_RS06950	COG0438	transferase activity, transferring glycosyl groups
HED66_RS06955	COG0438	transferase activity, transferring glycosyl groups
HED66_RS06975	COG0438	transferase activity, transferring glycosyl groups
HED66_RS07020	COG0438	transferase activity, transferring glycosyl groups
HED66_RS07025	COG1215	transferase activity, transferring glycosyl groups
HED66_RS07030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HED66_RS07070	COG2205	protein histidine kinase activity
HED66_RS07070	COG4999	Histidine kinase
HED66_RS07070	COG3437	response regulator, receiver
HED66_RS07070	COG3850	Histidine kinase
HED66_RS07090	COG0582	viral genome integration into host DNA
HED66_RS07095	COG2925	Exonuclease
HED66_RS07105	COG3345	alpha-galactosidase
HED66_RS07110	COG1380	Effector of murein hydrolase LrgA
HED66_RS07115	COG1346	cytolysis
HED66_RS07120	COG0295	cytidine deaminase activity
HED66_RS07125	COG1022	Amp-dependent synthetase and ligase
HED66_RS07145	COG2199	diguanylate cyclase activity
HED66_RS07160	COG2154	pterin-4-alpha-carbinolamine dehydratase
HED66_RS07170	COG3768	UPF0283 membrane protein
HED66_RS07175	COG3106	COG3106 Predicted ATPase
HED66_RS07190	COG1842	Phage shock protein A
HED66_RS07195	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HED66_RS07205	COG4168	peptide transport system, permease
HED66_RS07210	COG4171	peptide transport system, permease
HED66_RS07215	COG4172	Belongs to the ABC transporter superfamily
HED66_RS07220	COG4172	Belongs to the ABC transporter superfamily
HED66_RS07230	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HED66_RS07235	COG1286	toxin biosynthetic process
HED66_RS07240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HED66_RS07245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HED66_RS07250	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HED66_RS07255	COG0531	amino acid
HED66_RS07255	COG1674	ftsk spoiiie
HED66_RS07265	COG0686	Belongs to the AlaDH PNT family
HED66_RS07270	COG0492	ferredoxin-NADP+ reductase activity
HED66_RS07275	COG3706	GGDEF domain
HED66_RS07280	COG3134	Outer membrane lipoprotein
HED66_RS07285	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HED66_RS07290	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HED66_RS07295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HED66_RS07300	COG0542	response to heat
HED66_RS07305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HED66_RS07310	COG1278	Cold shock
HED66_RS07315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HED66_RS07345	COG3501	Rhs element vgr protein
HED66_RS07360	COG0659	secondary active sulfate transmembrane transporter activity
HED66_RS07395	COG0672	)-iron permease
HED66_RS07420	COG2814	Major facilitator Superfamily
HED66_RS07435	COG1136	(ABC) transporter
HED66_RS07455	COG1285	pathogenesis
HED66_RS07485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HED66_RS07490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HED66_RS07490	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HED66_RS07495	COG0527	aspartate kinase activity
HED66_RS07505	COG1368	sulfuric ester hydrolase activity
HED66_RS07510	COG1619	proteins homologs of microcin C7 resistance protein MccF
HED66_RS07520	COG0393	Putative heavy-metal-binding
HED66_RS07525	COG1252	NADH dehydrogenase
HED66_RS07530	COG3150	esterase
HED66_RS07545	COG2354	Protein conserved in bacteria
HED66_RS07555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HED66_RS07555	COG0047	phosphoribosylformylglycinamidine synthase activity
HED66_RS07560	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HED66_RS07565	COG1645	bacterial-type flagellum-dependent swarming motility
HED66_RS07570	COG1160	GTP binding
HED66_RS07575	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HED66_RS07580	COG2976	Protein conserved in bacteria
HED66_RS07585	COG0124	histidyl-tRNA synthetase
HED66_RS07595	COG1426	Protein conserved in bacteria
HED66_RS07605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HED66_RS07610	COG0105	UTP biosynthetic process
HED66_RS07615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HED66_RS07625	COG0633	Ferredoxin
HED66_RS07630	COG0443	Heat shock 70 kDa protein
HED66_RS07635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HED66_RS07645	COG0822	iron-sulfur transferase activity
HED66_RS07650	COG1104	cysteine desulfurase activity
HED66_RS07670	COG3154	lipid carrier protein
HED66_RS07675	COG0826	peptidase U32
HED66_RS07680	COG0826	peptidase U32
HED66_RS07695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HED66_RS07700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HED66_RS07705	COG1862	Preprotein translocase
HED66_RS07710	COG0343	queuine tRNA-ribosyltransferase activity
HED66_RS07715	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HED66_RS07720	COG0517	IMP dehydrogenase activity
HED66_RS07730	COG3634	alkyl hydroperoxide reductase activity
HED66_RS07750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HED66_RS07750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HED66_RS07755	COG0509	glycine decarboxylation via glycine cleavage system
HED66_RS07760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HED66_RS07765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HED66_RS07770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HED66_RS07790	COG0243	molybdopterin cofactor binding
HED66_RS07795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HED66_RS07800	COG0583	DNA-binding transcription factor activity
HED66_RS07805	COG2814	Major facilitator Superfamily
HED66_RS07810	COG0444	Belongs to the ABC transporter superfamily
HED66_RS07815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED66_RS07820	COG0601	transmembrane transport
HED66_RS07830	COG0625	glutathione transferase activity
HED66_RS07840	COG0483	inositol monophosphate 1-phosphatase activity
HED66_RS07860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HED66_RS07870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HED66_RS07905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HED66_RS07920	COG0301	tRNA thio-modification
HED66_RS07920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HED66_RS07930	COG4953	penicillin-binding protein 1C
HED66_RS07935	COG2373	Large extracellular alpha-helical protein
HED66_RS07940	COG0446	pyridine nucleotide-disulphide oxidoreductase
HED66_RS07950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HED66_RS08010	COG0438	transferase activity, transferring glycosyl groups
HED66_RS08010	COG1216	Glycosyl transferase, family 2
HED66_RS08020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HED66_RS08030	COG1091	dTDP-4-dehydrorhamnose reductase activity
HED66_RS08080	COG2431	L-lysine efflux transmembrane transporter activity
HED66_RS08095	COG1393	Belongs to the ArsC family
HED66_RS08105	COG4783	chaperone-mediated protein folding
HED66_RS08110	COG0425	Belongs to the sulfur carrier protein TusA family
HED66_RS08130	COG3842	ATPase activity
HED66_RS08135	COG3833	ABC-type maltose transport systems, permease component
HED66_RS08140	COG1175	transmembrane transport
HED66_RS08145	COG2182	Extracellular solute-binding protein
HED66_RS08150	COG3081	Nucleoid-associated protein
HED66_RS08155	COG3082	Protein of unknown function (DUF1414)
HED66_RS08160	COG3083	sulfuric ester hydrolase activity
HED66_RS08165	COG4771	TonB-dependent receptor
HED66_RS08170	COG1770	oligopeptidase
HED66_RS08190	COG4574	serine-type endopeptidase inhibitor activity
HED66_RS08195	COG3085	chromosome segregation
HED66_RS08200	COG0583	DNA-binding transcription factor activity
HED66_RS08205	COG1605	Chorismate mutase
HED66_RS08205	COG0287	Prephenate dehydrogenase
HED66_RS08210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HED66_RS08215	COG0584	glycerophosphoryl diester phosphodiesterase
HED66_RS08220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HED66_RS08225	COG1349	DNA-binding transcription factor activity
HED66_RS08230	COG2271	Major facilitator Superfamily
HED66_RS08235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HED66_RS08240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HED66_RS08245	COG0583	DNA-binding transcription factor activity
HED66_RS08265	COG0656	L-ascorbic acid biosynthetic process
HED66_RS08270	COG2814	Major facilitator Superfamily
HED66_RS08280	COG1294	oxidase, subunit
HED66_RS08290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HED66_RS08300	COG2979	Protein of unknown function (DUF533)
HED66_RS08320	COG0583	DNA-binding transcription factor activity
HED66_RS08330	COG2807	transmembrane transport
HED66_RS08340	COG1187	pseudouridine synthase activity
HED66_RS08345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HED66_RS08355	COG0346	lactoylglutathione lyase activity
HED66_RS08365	COG1403	HNH endonuclease
HED66_RS08385	COG1166	arginine decarboxylase activity
HED66_RS08390	COG2195	Cleaves the N-terminal amino acid of tripeptides
HED66_RS08415	COG2353	YceI-like domain
HED66_RS08420	COG0583	DNA-binding transcription factor activity
HED66_RS08430	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HED66_RS08435	COG0840	transmembrane signaling receptor activity
HED66_RS08440	COG0302	gtp cyclohydrolase
HED66_RS08445	COG0303	'Molybdopterin
HED66_RS08450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HED66_RS08455	COG0596	Alpha beta hydrolase
HED66_RS08460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HED66_RS08475	COG0314	molybdopterin synthase activity
HED66_RS08480	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HED66_RS08485	COG0315	cyclic pyranopterin monophosphate synthase activity
HED66_RS08490	COG0521	Mo-molybdopterin cofactor biosynthetic process
HED66_RS08495	COG3005	denitrification pathway
HED66_RS08505	COG0348	domain, Protein
HED66_RS08510	COG0437	4 iron, 4 sulfur cluster binding
HED66_RS08515	COG0243	molybdopterin cofactor binding
HED66_RS08530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HED66_RS08535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HED66_RS08540	COG3850	Histidine kinase
HED66_RS08545	COG2197	response regulator
HED66_RS08575	COG0121	glutamine amidotransferase
HED66_RS08580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HED66_RS08585	COG1960	acyl-CoA dehydrogenase activity
HED66_RS08590	COG0784	Response regulator, receiver
HED66_RS08590	COG3437	response regulator, receiver
HED66_RS08610	COG0328	RNA-DNA hybrid ribonuclease activity
HED66_RS08615	COG2226	methyltransferase
HED66_RS08620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HED66_RS08625	COG0741	lytic transglycosylase activity
HED66_RS08625	COG1388	LysM domain
HED66_RS08630	COG3021	interspecies interaction between organisms
HED66_RS08640	COG1607	acyl-coa hydrolase
HED66_RS08665	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HED66_RS08685	COG2911	Protein conserved in bacteria
HED66_RS08690	COG0729	surface antigen
HED66_RS08700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HED66_RS08715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HED66_RS08720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HED66_RS08725	COG4134	Bacterial extracellular solute-binding protein
HED66_RS08730	COG4135	transport system, permease component
HED66_RS08735	COG4136	ATPase activity
HED66_RS08740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HED66_RS08745	COG2951	lytic endotransglycosylase activity
HED66_RS08750	COG1846	Transcriptional regulator
HED66_RS08760	COG0033	Phosphoglucomutase
HED66_RS08765	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HED66_RS08770	COG0596	Alpha beta hydrolase
HED66_RS08785	COG0716	FMN binding
HED66_RS08795	COG0735	belongs to the Fur family
HED66_RS08800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HED66_RS08810	COG1263	PTS System
HED66_RS08810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HED66_RS08810	COG2190	(PTS) system
HED66_RS08815	COG0363	glucosamine-6-phosphate deaminase activity
HED66_RS08820	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HED66_RS08825	COG1846	Transcriptional regulator
HED66_RS08825	COG1940	carbohydrate kinase activity
HED66_RS08835	COG0217	transcriptional regulatory protein
HED66_RS08840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HED66_RS08850	COG1801	Protein of unknown function DUF72
HED66_RS08855	COG4106	trans-aconitate 2-methyltransferase activity
HED66_RS08860	COG0500	methyltransferase
HED66_RS08880	COG0450	alkyl hydroperoxide reductase
HED66_RS08885	COG0583	DNA-binding transcription factor activity
HED66_RS08895	COG0791	NLP P60 protein
HED66_RS08910	COG1309	transcriptional regulator
HED66_RS08950	COG0534	Mate efflux family protein
HED66_RS08960	COG2841	Protein conserved in bacteria
HED66_RS08980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HED66_RS08980	COG1013	pyruvate-flavodoxin oxidoreductase activity
HED66_RS08980	COG0674	pyruvate-flavodoxin oxidoreductase activity
HED66_RS08980	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HED66_RS08990	COG0633	Ferredoxin
HED66_RS08990	COG0633	Ferredoxin
HED66_RS08990	COG3217	Mosc domain protein beta barrel domain protein
HED66_RS08990	COG3217	Mosc domain protein beta barrel domain protein
HED66_RS09000	COG0501	Belongs to the peptidase M48B family
HED66_RS09005	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HED66_RS09010	COG2226	methyltransferase
HED66_RS09010	COG1073	alpha beta
HED66_RS09015	COG0156	8-amino-7-oxononanoate synthase activity
HED66_RS09020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HED66_RS09040	COG0017	Asparaginyl-tRNA synthetase
HED66_RS09045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HED66_RS09060	COG0583	DNA-binding transcription factor activity
HED66_RS09075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HED66_RS09090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HED66_RS09095	COG1393	Belongs to the ArsC family
HED66_RS09100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HED66_RS09105	COG1876	peptidase activity
HED66_RS09115	COG3263	regulation of cellular component size
HED66_RS09135	COG1280	lysine exporter protein (LysE YggA)
HED66_RS09140	COG0840	transmembrane signaling receptor activity
HED66_RS09160	COG1957	nucleoside hydrolase
HED66_RS09175	COG1454	alcohol dehydrogenase
HED66_RS09225	COG4964	Belongs to the GSP D family
HED66_RS09255	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HED66_RS09260	COG0702	epimerase
HED66_RS09270	COG2867	negative regulation of translational initiation
HED66_RS09275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HED66_RS09285	COG4974	Belongs to the 'phage' integrase family
HED66_RS09330	COG0583	DNA-binding transcription factor activity
HED66_RS09335	COG2610	gluconate transmembrane transporter activity
HED66_RS09340	COG3048	D-serine ammonia-lyase activity
HED66_RS09350	COG0538	isocitrate dehydrogenase activity
HED66_RS09355	COG2207	Transcriptional regulator
HED66_RS09370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HED66_RS09390	COG2814	Major facilitator Superfamily
HED66_RS09395	COG0109	protoheme IX farnesyltransferase activity
HED66_RS09405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HED66_RS09410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HED66_RS09465	COG0708	Exodeoxyribonuclease III
HED66_RS09475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HED66_RS09480	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HED66_RS09490	COG0095	Lipoate-protein ligase
HED66_RS09535	COG1285	pathogenesis
HED66_RS09565	COG0484	heat shock protein binding
HED66_RS09570	COG0443	Heat shock 70 kDa protein
HED66_RS09575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HED66_RS09580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HED66_RS09585	COG0497	DNA recombination
HED66_RS09590	COG1227	inorganic diphosphatase activity
HED66_RS09600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HED66_RS09605	COG0577	efflux transmembrane transporter activity
HED66_RS09605	COG1136	(ABC) transporter
HED66_RS09610	COG1538	Outer membrane efflux protein
HED66_RS09615	COG2375	cellular response to nickel ion
HED66_RS09620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HED66_RS09630	COG2916	Histone family protein nucleoid-structuring protein H-NS
HED66_RS09655	COG2169	Transcriptional regulator
HED66_RS09655	COG1917	Cupin 2, conserved barrel domain protein
HED66_RS09665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HED66_RS09670	COG1917	Cupin 2, conserved barrel domain protein
HED66_RS09670	COG1396	sequence-specific DNA binding
HED66_RS09685	COG0531	amino acid
HED66_RS09690	COG0531	amino acid
HED66_RS09705	COG3384	dioxygenase
HED66_RS09710	COG2205	protein histidine kinase activity
HED66_RS09710	COG5002	protein histidine kinase activity
HED66_RS09710	COG0784	Response regulator, receiver
HED66_RS09715	COG5001	Diguanylate cyclase
HED66_RS09715	COG4251	negative regulation of phosphorylation
HED66_RS09715	COG3706	GGDEF domain
HED66_RS09715	COG2203	Gaf domain
HED66_RS09730	COG0813	purine-nucleoside phosphorylase activity
HED66_RS09770	COG4319	ketosteroid isomerase
HED66_RS09775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HED66_RS09780	COG0083	homoserine kinase activity
HED66_RS09790	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HED66_RS09795	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HED66_RS09810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HED66_RS09820	COG0745	RESPONSE REGULATOR receiver
HED66_RS09835	COG4988	ABC transporter
HED66_RS09840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HED66_RS09860	COG1720	tRNA m6t6A37 methyltransferase activity
HED66_RS09865	COG2770	Histidine kinase
HED66_RS09865	COG3437	response regulator, receiver
HED66_RS09885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HED66_RS09890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HED66_RS09900	COG2190	(PTS) system
HED66_RS09905	COG3706	GGDEF domain
HED66_RS09915	COG3038	cytochrome b561
HED66_RS09920	COG0419	ATPase involved in DNA repair
HED66_RS09925	COG0420	3'-5' exonuclease activity
HED66_RS09935	COG2974	May be involved in recombination
HED66_RS09940	COG0405	Gamma-glutamyltransferase
HED66_RS09945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HED66_RS09945	COG4651	solute:proton antiporter activity
HED66_RS09960	COG0469	pyruvate kinase activity
HED66_RS09965	COG1196	nuclear chromosome segregation
HED66_RS09965	COG3264	Mechanosensitive ion channel
HED66_RS09985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED66_RS10005	COG0281	malic enzyme
HED66_RS10020	COG0437	4 iron, 4 sulfur cluster binding
HED66_RS10025	COG3383	formate dehydrogenase (NAD+) activity
HED66_RS10065	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HED66_RS10075	COG3852	Histidine kinase
HED66_RS10080	COG2204	response regulator
HED66_RS10090	COG4662	Binding-protein-dependent transport system inner membrane component
HED66_RS10100	COG0746	molybdenum cofactor guanylyltransferase activity
HED66_RS10105	COG0303	'Molybdopterin
HED66_RS10110	COG1289	transmembrane transporter activity
HED66_RS10115	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HED66_RS10140	COG3220	belongs to the UPF0276 family
HED66_RS10170	COG2205	protein histidine kinase activity
HED66_RS10170	COG0784	Response regulator, receiver
HED66_RS10185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HED66_RS10190	COG0444	Belongs to the ABC transporter superfamily
HED66_RS10195	COG4608	Belongs to the ABC transporter superfamily
HED66_RS10205	COG2971	BadF BadG BcrA BcrD
HED66_RS10215	COG0840	transmembrane signaling receptor activity
HED66_RS10235	COG3724	N-succinylarginine dihydrolase activity
HED66_RS10240	COG0616	signal peptide processing
HED66_RS10245	COG1028	Short-chain dehydrogenase reductase Sdr
HED66_RS10250	COG0583	DNA-binding transcription factor activity
HED66_RS10260	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HED66_RS10270	COG0583	DNA-binding transcription factor activity
HED66_RS10280	COG1881	PFAM PEBP family protein
HED66_RS10290	COG0366	Alpha amylase catalytic
HED66_RS10340	COG2199	diguanylate cyclase activity
HED66_RS10340	COG2203	Gaf domain
HED66_RS10345	COG0037	tRNA processing
HED66_RS10350	COG3590	peptidase
HED66_RS10360	COG0488	(ABC) transporter
HED66_RS10370	COG0531	amino acid
HED66_RS10375	COG0814	amino acid
HED66_RS10390	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HED66_RS10395	COG1982	Orn Lys Arg decarboxylase major
HED66_RS10400	COG0531	amino acid
HED66_RS10405	COG3710	Transcriptional regulator
HED66_RS10410	COG0825	malonyl-CoA metabolic process
HED66_RS10420	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HED66_RS10425	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HED66_RS10430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HED66_RS10435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HED66_RS10440	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HED66_RS10455	COG0750	zinc metalloprotease
HED66_RS10460	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HED66_RS10465	COG0575	Belongs to the CDS family
HED66_RS10470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HED66_RS10475	COG0233	cytoplasmic translational termination
HED66_RS10480	COG0528	UMP kinase activity
HED66_RS10485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HED66_RS10490	COG0052	Belongs to the universal ribosomal protein uS2 family
HED66_RS10495	COG0024	Methionine aminopeptidase
HED66_RS10500	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HED66_RS10505	COG2171	N-acyltransferase activity
HED66_RS10515	COG1263	PTS System
HED66_RS10515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HED66_RS10525	COG4580	involved in the transport of maltose and maltodextrins
HED66_RS10535	COG0564	pseudouridine synthase activity
HED66_RS10540	COG3098	single-species biofilm formation
HED66_RS10565	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HED66_RS10575	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HED66_RS10575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HED66_RS10585	COG3706	GGDEF domain
HED66_RS10590	COG1611	Belongs to the LOG family
HED66_RS10595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HED66_RS10600	COG0473	3-isopropylmalate dehydrogenase activity
HED66_RS10610	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HED66_RS10615	COG2363	Small membrane protein
HED66_RS10625	COG0583	DNA-binding transcription factor activity
HED66_RS10630	COG0840	transmembrane signaling receptor activity
HED66_RS10635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HED66_RS10650	COG1477	protein flavinylation
HED66_RS10655	COG2871	sodium ion transport
HED66_RS10660	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HED66_RS10665	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HED66_RS10670	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HED66_RS10675	COG1805	sodium ion transport
HED66_RS10680	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HED66_RS10690	COG0271	Belongs to the BolA IbaG family
HED66_RS10695	COG2813	Specifically methylates the guanine in position
HED66_RS10705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HED66_RS10715	COG2211	Major facilitator Superfamily
HED66_RS10720	COG3248	Nucleoside-binding outer membrane protein
HED66_RS10725	COG1666	GTP binding
HED66_RS10730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HED66_RS10755	COG3459	Glycosyltransferase 36 associated
HED66_RS10775	COG3501	Rhs element vgr protein
HED66_RS10790	COG2771	luxR family
HED66_RS10800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HED66_RS10800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HED66_RS10805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HED66_RS10815	COG1151	hydroxylamine reductase activity
HED66_RS10820	COG0783	Belongs to the Dps family
HED66_RS10845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HED66_RS10860	COG0300	oxidoreductase activity
HED66_RS10870	COG0415	Belongs to the DNA photolyase family
HED66_RS10875	COG0789	Transcriptional regulator
HED66_RS10880	COG3272	Protein of unknown function (DUF1722)
HED66_RS10910	COG0077	Prephenate dehydratase
HED66_RS10910	COG1605	Chorismate mutase
HED66_RS10935	COG2133	pyrroloquinoline quinone binding
HED66_RS10960	COG0300	oxidoreductase activity
HED66_RS10985	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HED66_RS11000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HED66_RS11010	COG3813	Protein conserved in bacteria
HED66_RS11020	COG0826	peptidase U32
HED66_RS11025	COG1280	lysine exporter protein (LysE YggA)
HED66_RS11040	COG0840	transmembrane signaling receptor activity
HED66_RS11055	COG2198	Histidine kinase
HED66_RS11055	COG0643	Histidine kinase
HED66_RS11065	COG0835	chemotaxis
HED66_RS11070	COG0840	transmembrane signaling receptor activity
HED66_RS11080	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HED66_RS11085	COG2201	protein-glutamate methylesterase activity
HED66_RS11090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HED66_RS11130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HED66_RS11135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HED66_RS11150	COG2200	EAL domain
HED66_RS11155	COG0737	Belongs to the 5'-nucleotidase family
HED66_RS11175	COG2204	response regulator
HED66_RS11180	COG0545	Peptidyl-prolyl cis-trans isomerase
HED66_RS11195	COG1047	Peptidyl-prolyl cis-trans
HED66_RS11200	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HED66_RS11210	COG0784	Response regulator, receiver
HED66_RS11210	COG0835	chemotaxis
HED66_RS11215	COG0429	hydrolase of the alpha beta-hydrolase fold
HED66_RS11220	COG5001	Diguanylate cyclase
HED66_RS11220	COG2203	Gaf domain
HED66_RS11220	COG4251	negative regulation of phosphorylation
HED66_RS11220	COG3706	GGDEF domain
HED66_RS11225	COG3089	Belongs to the UPF0270 family
HED66_RS11235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HED66_RS11240	COG0463	Glycosyl transferase, family 2
HED66_RS11245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HED66_RS11245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HED66_RS11250	COG0726	polysaccharide deacetylase
HED66_RS11255	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HED66_RS11260	COG2076	Multidrug Resistance protein
HED66_RS11265	COG2076	Multidrug Resistance protein
HED66_RS11270	COG3954	Phosphoribulokinase
HED66_RS11285	COG1765	OsmC-like protein
HED66_RS11295	COG2226	methyltransferase
HED66_RS11300	COG3397	chitin binding
HED66_RS11315	COG2205	protein histidine kinase activity
HED66_RS11315	COG2202	Pas domain
HED66_RS11325	COG3655	Transcriptional regulator
HED66_RS11335	COG2814	Major facilitator Superfamily
HED66_RS11340	COG4771	TonB-dependent receptor
HED66_RS11360	COG0748	coenzyme F420 binding
HED66_RS11365	COG3721	Heme iron utilization protein
HED66_RS11375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED66_RS11395	COG0741	lytic transglycosylase activity
HED66_RS11400	COG0488	(ABC) transporter
HED66_RS11410	COG2252	PERMEase
HED66_RS11415	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HED66_RS11420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HED66_RS11425	COG3178	'Phosphotransferase
HED66_RS11430	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HED66_RS11440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HED66_RS11445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HED66_RS11450	COG2967	ApaG domain
HED66_RS11455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HED66_RS11475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HED66_RS11495	COG0318	PFAM AMP-dependent synthetase and ligase
HED66_RS11505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HED66_RS11510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HED66_RS11515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HED66_RS11520	COG0142	geranyltranstransferase activity
HED66_RS11525	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HED66_RS11530	COG0330	HflC and HflK could
HED66_RS11535	COG0330	HflC and HflK could
HED66_RS11540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HED66_RS11545	COG1923	regulation of RNA biosynthetic process
HED66_RS11550	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HED66_RS11555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HED66_RS11565	COG0802	atpase or kinase
HED66_RS11570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HED66_RS11570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HED66_RS11590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HED66_RS11595	COG2011	ABC-type metal ion transport system permease component
HED66_RS11600	COG1464	Belongs to the NlpA lipoprotein family
HED66_RS11610	COG0840	transmembrane signaling receptor activity
HED66_RS11635	COG2198	Histidine kinase
HED66_RS11635	COG0784	Response regulator, receiver
HED66_RS11635	COG5002	protein histidine kinase activity
HED66_RS11670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HED66_RS11675	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HED66_RS11685	COG2716	regulation of RNA biosynthetic process
HED66_RS11690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HED66_RS11695	COG3013	Belongs to the UPF0304 family
HED66_RS11705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HED66_RS11710	COG0280	phosphate acetyltransferase
HED66_RS11710	COG0857	belongs to the CobB CobQ family
HED66_RS11715	COG0440	acetolactate synthase activity
HED66_RS11720	COG0028	Belongs to the TPP enzyme family
HED66_RS11735	COG0671	phosphoesterase, PA-phosphatase related
HED66_RS11745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HED66_RS11750	COG0473	3-isopropylmalate dehydrogenase activity
HED66_RS11755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HED66_RS11760	COG0066	3-isopropylmalate dehydratase activity
HED66_RS11775	COG4143	(ABC) transporter
HED66_RS11780	COG1178	ABC-type Fe3 transport system permease component
HED66_RS11785	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HED66_RS11790	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HED66_RS11800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HED66_RS11830	COG0316	Belongs to the HesB IscA family
HED66_RS11840	COG0038	chloride channel
HED66_RS11845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HED66_RS11860	COG0671	phosphoesterase, PA-phosphatase related
HED66_RS11870	COG0784	Response regulator, receiver
HED66_RS11870	COG3437	response regulator, receiver
HED66_RS11875	COG0583	DNA-binding transcription factor activity
HED66_RS11880	COG2076	Multidrug Resistance protein
HED66_RS11890	COG0346	lactoylglutathione lyase activity
HED66_RS11895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HED66_RS11900	COG1643	Atp-dependent helicase
HED66_RS11910	COG1489	DNA binding
HED66_RS11915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HED66_RS11920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HED66_RS11925	COG0617	tRNA 3'-terminal CCA addition
HED66_RS11930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HED66_RS11935	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HED66_RS11940	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HED66_RS11950	COG0842	Transport permease protein
HED66_RS11955	COG1131	(ABC) transporter
HED66_RS11970	COG0163	prenyltransferase activity
HED66_RS11975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HED66_RS11980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HED66_RS11985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HED66_RS11995	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HED66_RS11995	COG0506	proline dehydrogenase activity
HED66_RS11995	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HED66_RS12000	COG4991	sh3 domain protein
HED66_RS12005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HED66_RS12025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HED66_RS12030	COG1640	4-alpha-glucanotransferase
HED66_RS12035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HED66_RS12045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HED66_RS12050	COG0840	transmembrane signaling receptor activity
HED66_RS12125	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HED66_RS12130	COG2885	chlorophyll binding
HED66_RS12135	COG0823	Involved in the tonB-independent uptake of proteins
HED66_RS12150	COG0811	peptide transport
HED66_RS12155	COG0824	Thioesterase
HED66_RS12160	COG3790	cyd operon protein YbgE
HED66_RS12165	COG4890	Cyd operon protein YbgT
HED66_RS12170	COG1294	oxidase, subunit
HED66_RS12175	COG1271	oxidase subunit
HED66_RS12180	COG2255	four-way junction helicase activity
HED66_RS12185	COG0632	four-way junction helicase activity
HED66_RS12190	COG0840	transmembrane signaling receptor activity
HED66_RS12195	COG0442	prolyl-tRNA aminoacylation
HED66_RS12205	COG1902	pentaerythritol trinitrate reductase activity
HED66_RS12210	COG0456	acetyltransferase
HED66_RS12215	COG0456	acetyltransferase
HED66_RS12225	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HED66_RS12235	COG3300	MHYT domain
HED66_RS12235	COG5001	Diguanylate cyclase
HED66_RS12255	COG0714	Associated with various cellular activities
HED66_RS12265	COG0456	acetyltransferase
HED66_RS12275	COG1022	Amp-dependent synthetase and ligase
HED66_RS12285	COG2918	glutathione biosynthetic process
HED66_RS12290	COG0612	Peptidase, M16
HED66_RS12295	COG1238	metal cluster binding
HED66_RS12300	COG1064	alcohol dehydrogenase
HED66_RS12330	COG0359	binds to the 23S rRNA
HED66_RS12335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HED66_RS12340	COG0360	Binds together with S18 to 16S ribosomal RNA
HED66_RS12345	COG1914	H( )-stimulated, divalent metal cation uptake system
HED66_RS12350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HED66_RS12355	COG0583	DNA-binding transcription factor activity
HED66_RS12365	COG2814	Major facilitator Superfamily
HED66_RS12390	COG2153	protein acetylation
HED66_RS12400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HED66_RS12405	COG0557	exoribonuclease II activity
HED66_RS12410	COG3706	GGDEF domain
HED66_RS12415	COG1854	S-ribosylhomocysteine lyase activity
HED66_RS12430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HED66_RS12430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HED66_RS12490	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HED66_RS12495	COG1047	Peptidyl-prolyl cis-trans
HED66_RS12500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HED66_RS12505	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HED66_RS12510	COG0196	riboflavin kinase activity
HED66_RS12515	COG0728	peptidoglycan biosynthetic process
HED66_RS12520	COG0268	Binds directly to 16S ribosomal RNA
HED66_RS12525	COG0640	Transcriptional regulator
HED66_RS12530	COG0583	DNA-binding transcription factor activity
HED66_RS12540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HED66_RS12545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HED66_RS12550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HED66_RS12560	COG1051	belongs to the nudix hydrolase family
HED66_RS12565	COG3066	DNA modification
HED66_RS12575	COG0335	large ribosomal subunit rRNA binding
HED66_RS12580	COG0336	Belongs to the RNA methyltransferase TrmD family
HED66_RS12585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HED66_RS12590	COG0228	four-way junction DNA binding
HED66_RS12595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HED66_RS12600	COG4137	Cytochrome C assembly protein
HED66_RS12605	COG4536	flavin adenine dinucleotide binding
HED66_RS12610	COG1959	2 iron, 2 sulfur cluster binding
HED66_RS12615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HED66_RS12615	COG1017	nitric oxide dioxygenase activity
HED66_RS12620	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HED66_RS12625	COG0039	L-malate dehydrogenase activity
HED66_RS12630	COG4160	amino acid transport
HED66_RS12635	COG4215	(ABC) transporter
HED66_RS12640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED66_RS12645	COG1126	abc transporter atp-binding protein
HED66_RS12650	COG1438	arginine binding
HED66_RS12655	COG2837	iron assimilation
HED66_RS12660	COG3842	ATPase activity
HED66_RS12670	COG1840	ABC-type Fe3 transport system, periplasmic component
HED66_RS12675	COG0347	Belongs to the P(II) protein family
HED66_RS12690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HED66_RS12710	COG1929	Belongs to the glycerate kinase type-1 family
HED66_RS12715	COG2610	gluconate transmembrane transporter activity
HED66_RS12720	COG3835	regulator
HED66_RS12725	COG3112	Uncharacterised protein family (UPF0231)
HED66_RS12740	COG3568	Endonuclease Exonuclease Phosphatase
HED66_RS12755	COG0513	Belongs to the DEAD box helicase family
HED66_RS12795	COG1448	Aminotransferase
HED66_RS12810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HED66_RS12815	COG1328	CTP reductase activity
HED66_RS12835	COG0793	Belongs to the peptidase S41A family
HED66_RS12835	COG4946	Tricorn protease homolog
HED66_RS12850	COG1215	transferase activity, transferring glycosyl groups
HED66_RS12855	COG1649	PFAM Uncharacterised BCR, COG1649
HED66_RS12855	COG0726	polysaccharide deacetylase
HED66_RS12875	COG0840	transmembrane signaling receptor activity
HED66_RS12880	COG3397	chitin binding
HED66_RS12885	COG0583	DNA-binding transcription factor activity
HED66_RS12890	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HED66_RS12895	COG4208	sulfate ABC transporter
HED66_RS12900	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HED66_RS12910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HED66_RS12915	COG3174	membrane
HED66_RS12920	COG0110	maltose O-acetyltransferase activity
HED66_RS12950	COG1942	4-Oxalocrotonate Tautomerase
HED66_RS12960	COG0583	DNA-binding transcription factor activity
HED66_RS12965	COG0165	Argininosuccinate lyase
HED66_RS12970	COG0137	argininosuccinate synthase activity
HED66_RS12980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HED66_RS12985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HED66_RS12995	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HED66_RS13005	COG2072	flavoprotein involved in K transport
HED66_RS13010	COG1393	Belongs to the ArsC family
HED66_RS13015	COG0798	PFAM Bile acid sodium symporter
HED66_RS13030	COG0640	Transcriptional regulator
HED66_RS13035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HED66_RS13055	COG3068	Protein conserved in bacteria
HED66_RS13065	COG0739	heme binding
HED66_RS13085	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HED66_RS13090	COG1121	(ABC) transporter
HED66_RS13095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HED66_RS13100	COG0583	DNA-binding transcription factor activity
HED66_RS13110	COG1573	uracil-dna glycosylase
HED66_RS13115	COG2962	Rard protein
HED66_RS13125	COG2827	Endonuclease containing a URI domain
HED66_RS13140	COG1842	Phage shock protein A
HED66_RS13145	COG0204	Acyl-transferase
HED66_RS13165	COG3118	belongs to the thioredoxin family
HED66_RS13230	COG1051	belongs to the nudix hydrolase family
HED66_RS13235	COG3150	esterase
HED66_RS13245	COG3151	Protein conserved in bacteria
HED66_RS13250	COG0494	nUDIX hydrolase
HED66_RS13255	COG1538	Outer membrane efflux protein
HED66_RS13260	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HED66_RS13260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HED66_RS13265	COG1560	Kdo2-lipid A biosynthetic process
HED66_RS13280	COG1392	Phosphate transport regulator
HED66_RS13285	COG0306	phosphate transporter
HED66_RS13290	COG0617	tRNA 3'-terminal CCA addition
HED66_RS13295	COG3409	Peptidoglycan-binding domain 1 protein
HED66_RS13295	COG3267	Type II secretory pathway component ExeA
HED66_RS13305	COG1194	a g-specific adenine glycosylase
HED66_RS13310	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HED66_RS13320	COG3111	PFAM Bacterial OB fold (BOF) protein
HED66_RS13325	COG3240	lipase activity
HED66_RS13340	COG3009	Protein conserved in bacteria
HED66_RS13345	COG3008	intermembrane lipid transfer
HED66_RS13345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HED66_RS13350	COG2995	paraquat-inducible protein a
HED66_RS13360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HED66_RS13370	COG3706	GGDEF domain
HED66_RS13370	COG5001	Diguanylate cyclase
HED66_RS13370	COG2203	Gaf domain
HED66_RS13370	COG4251	negative regulation of phosphorylation
HED66_RS13375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HED66_RS13380	COG2813	Specifically methylates the guanine in position
HED66_RS13385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HED66_RS13390	COG0297	glycogen (starch) synthase activity
HED66_RS13430	COG1757	Na H antiporter
HED66_RS13450	COG0110	maltose O-acetyltransferase activity
HED66_RS13455	COG0366	Alpha amylase catalytic
HED66_RS13460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HED66_RS13460	COG1263	PTS System
HED66_RS13475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HED66_RS13480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HED66_RS13485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HED66_RS13485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HED66_RS13490	COG2723	6-phospho-beta-galactosidase activity
HED66_RS13495	COG1447	Phosphotransferase system cellobiose-specific component IIA
HED66_RS13500	COG1940	carbohydrate kinase activity
HED66_RS13510	COG1609	Transcriptional regulator
HED66_RS13520	COG0252	asparaginase activity
HED66_RS13535	COG1803	Methylglyoxal synthase
HED66_RS13560	COG1444	tRNA N-acetyltransferase activity
HED66_RS13570	COG0835	chemotaxis
HED66_RS13570	COG0784	Response regulator, receiver
HED66_RS13620	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HED66_RS13625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HED66_RS13640	COG0477	Major facilitator Superfamily
HED66_RS13645	COG0523	cobalamin synthesis protein
HED66_RS13655	COG1280	lysine exporter protein (LysE YggA)
HED66_RS13665	COG0583	DNA-binding transcription factor activity
HED66_RS13670	COG1028	Short-chain dehydrogenase reductase Sdr
HED66_RS13675	COG2200	EAL domain
HED66_RS13680	COG1049	propionate catabolic process, 2-methylcitrate cycle
HED66_RS13690	COG0840	transmembrane signaling receptor activity
HED66_RS13695	COG0840	transmembrane signaling receptor activity
HED66_RS13705	COG3447	MASE1 domain protein
HED66_RS13705	COG5002	protein histidine kinase activity
HED66_RS13705	COG5001	Diguanylate cyclase
HED66_RS13710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HED66_RS13715	COG0508	dehydrogenase complex catalyzes the overall conversion of
HED66_RS13720	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HED66_RS13725	COG2186	Transcriptional regulator
HED66_RS13750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HED66_RS13755	COG1459	type II secretion system
HED66_RS13760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HED66_RS13770	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HED66_RS13775	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HED66_RS13780	COG0494	nUDIX hydrolase
HED66_RS13785	COG0653	protein targeting
HED66_RS13795	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HED66_RS13800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HED66_RS13805	COG0849	cell division
HED66_RS13810	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HED66_RS13815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HED66_RS13820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HED66_RS13825	COG0772	Belongs to the SEDS family
HED66_RS13830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HED66_RS13835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HED66_RS13840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HED66_RS13850	COG0768	penicillin binding
HED66_RS13855	COG3116	cell division
HED66_RS13860	COG0275	rRNA processing
HED66_RS13865	COG2001	Belongs to the MraZ family
HED66_RS13875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HED66_RS13880	COG3107	peptidoglycan biosynthetic process
HED66_RS13885	COG0792	nuclease activity
HED66_RS13890	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HED66_RS13895	COG2823	Periplasmic or secreted lipoprotein
HED66_RS13900	COG2969	positive regulation of protein catabolic process
HED66_RS13905	COG0625	glutathione transferase activity
HED66_RS13910	COG2857	Cytochrome c1
HED66_RS13915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HED66_RS13920	COG0723	plastoquinol--plastocyanin reductase activity
HED66_RS13925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HED66_RS13930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HED66_RS13935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HED66_RS13945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HED66_RS13950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HED66_RS13980	COG3964	amidohydrolase
HED66_RS14000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HED66_RS14005	COG1660	Displays ATPase and GTPase activities
HED66_RS14010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HED66_RS14020	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HED66_RS14025	COG1137	ATPase activity
HED66_RS14030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HED66_RS14035	COG3117	lipopolysaccharide transmembrane transporter activity
HED66_RS14040	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HED66_RS14045	COG0517	IMP dehydrogenase activity
HED66_RS14045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HED66_RS14050	COG1127	ABC transporter
HED66_RS14055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HED66_RS14060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HED66_RS14065	COG2854	intermembrane phospholipid transfer
HED66_RS14075	COG5007	Belongs to the BolA IbaG family
HED66_RS14080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HED66_RS14085	COG0312	modulator of DNA gyrase
HED66_RS14090	COG3028	Belongs to the UPF0307 family
HED66_RS14100	COG2926	Belongs to the UPF0265 family
HED66_RS14130	COG1396	sequence-specific DNA binding
HED66_RS14135	COG3135	benzoate transporter
HED66_RS14165	COG3047	cAMP biosynthetic process
HED66_RS14175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HED66_RS14180	COG2197	response regulator
HED66_RS14205	COG1278	Cold shock
HED66_RS14210	COG4771	TonB-dependent receptor
HED66_RS14215	COG3706	GGDEF domain
HED66_RS14220	COG2205	protein histidine kinase activity
HED66_RS14225	COG0745	RESPONSE REGULATOR receiver
HED66_RS14245	COG0840	transmembrane signaling receptor activity
HED66_RS14260	COG0347	Belongs to the P(II) protein family
HED66_RS14265	COG0004	ammonium transporteR
HED66_RS14280	COG0346	lactoylglutathione lyase activity
HED66_RS14300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HED66_RS14305	COG1074	ATP-dependent DNA helicase activity
HED66_RS14310	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HED66_RS14315	COG2259	Doxx family
HED66_RS14320	COG1741	Belongs to the pirin family
HED66_RS14330	COG0583	DNA-binding transcription factor activity
HED66_RS14355	COG1176	ABC-type spermidine putrescine transport system, permease component I
HED66_RS14365	COG3842	ATPase activity
HED66_RS14375	COG2199	diguanylate cyclase activity
HED66_RS14375	COG2203	Gaf domain
HED66_RS14395	COG1247	-acetyltransferase
HED66_RS14400	COG0753	catalase activity
HED66_RS14425	COG0494	nUDIX hydrolase
HED66_RS14430	COG0628	permease
HED66_RS14445	COG3284	Transcriptional regulator
HED66_RS14460	COG1461	Dihydroxyacetone kinase
HED66_RS14465	COG2376	Dihydroxyacetone kinase
HED66_RS14470	COG2252	PERMEase
HED66_RS14505	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HED66_RS14510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HED66_RS14515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HED66_RS14520	COG0049	tRNA binding
HED66_RS14525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HED66_RS14530	COG2168	tRNA wobble position uridine thiolation
HED66_RS14535	COG2923	Belongs to the DsrF TusC family
HED66_RS14545	COG0251	oxidation-reduction process
HED66_RS14550	COG2964	Protein conserved in bacteria
HED66_RS14555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HED66_RS14560	COG0085	RNA polymerase activity
HED66_RS14565	COG0222	ribosome binding
HED66_RS14570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HED66_RS14575	COG0081	regulation of translation
HED66_RS14580	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HED66_RS14585	COG0250	Participates in transcription elongation, termination and antitermination
HED66_RS14600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HED66_RS14625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HED66_RS14630	COG0569	domain protein
HED66_RS14635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HED66_RS14640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HED66_RS14645	COG3005	denitrification pathway
HED66_RS14650	COG0243	molybdopterin cofactor binding
HED66_RS14660	COG2205	protein histidine kinase activity
HED66_RS14665	COG0745	RESPONSE REGULATOR receiver
HED66_RS14680	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HED66_RS14685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HED66_RS14695	COG2204	response regulator
HED66_RS14705	COG2205	protein histidine kinase activity
HED66_RS14720	COG1028	Short-chain dehydrogenase reductase Sdr
HED66_RS14725	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HED66_RS14725	COG0517	IMP dehydrogenase activity
HED66_RS14725	COG0617	tRNA 3'-terminal CCA addition
HED66_RS14730	COG5413	integral membrane protein
HED66_RS14740	COG1522	sequence-specific DNA binding
HED66_RS14745	COG2502	aspartate--ammonia ligase
HED66_RS14750	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HED66_RS14755	COG0542	response to heat
HED66_RS14765	COG0564	pseudouridine synthase activity
HED66_RS14770	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HED66_RS14775	COG0446	pyridine nucleotide-disulphide oxidoreductase
HED66_RS14785	COG3681	Belongs to the UPF0597 family
HED66_RS14790	COG2964	Protein conserved in bacteria
HED66_RS14800	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HED66_RS14805	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HED66_RS14810	COG1979	alcohol dehydrogenase
HED66_RS14815	COG2207	Transcriptional regulator
HED66_RS14820	COG3040	lipid binding
HED66_RS14830	COG0688	phosphatidylethanolamine metabolic process
HED66_RS14845	COG0540	Belongs to the ATCase OTCase family
HED66_RS14850	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HED66_RS14855	COG1438	arginine binding
HED66_RS14860	COG1288	antiporter activity
HED66_RS14865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HED66_RS14895	COG0840	transmembrane signaling receptor activity
HED66_RS14900	COG4211	Belongs to the binding-protein-dependent transport system permease family
HED66_RS14915	COG3250	beta-galactosidase activity
HED66_RS14920	COG1609	Transcriptional regulator
HED66_RS14925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HED66_RS14935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HED66_RS14940	COG2017	converts alpha-aldose to the beta-anomer
HED66_RS14945	COG0667	Aldo Keto reductase
HED66_RS14950	COG1968	undecaprenyl-diphosphatase activity
HED66_RS14960	COG1595	DNA-templated transcription, initiation
HED66_RS14980	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HED66_RS14985	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HED66_RS15000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HED66_RS15010	COG2116	formate transmembrane transporter activity
HED66_RS15015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HED66_RS15015	COG1648	precorrin-2 dehydrogenase activity
HED66_RS15020	COG2239	Acts as a magnesium transporter
HED66_RS15030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HED66_RS15035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HED66_RS15045	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HED66_RS15055	COG0514	ATP-dependent DNA helicase (RecQ)
HED66_RS15060	COG2050	protein possibly involved in aromatic compounds catabolism
HED66_RS15075	COG2258	MOSC domain
HED66_RS15080	COG1177	transmembrane transport
HED66_RS15085	COG1176	ABC-type spermidine putrescine transport system, permease component I
HED66_RS15090	COG3842	ATPase activity
HED66_RS15110	COG0174	glutamine synthetase
HED66_RS15125	COG3045	CreA protein
HED66_RS15130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HED66_RS15135	COG0443	Heat shock 70 kDa protein
HED66_RS15150	COG0366	Alpha amylase catalytic
HED66_RS15155	COG1086	Polysaccharide biosynthesis protein
HED66_RS15160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HED66_RS15170	COG0463	Glycosyl transferase, family 2
HED66_RS15175	COG1215	transferase activity, transferring glycosyl groups
HED66_RS15185	COG1215	transferase activity, transferring glycosyl groups
HED66_RS15200	COG0318	PFAM AMP-dependent synthetase and ligase
HED66_RS15205	COG1028	Short-chain dehydrogenase reductase Sdr
HED66_RS15220	COG1083	cytidylyl-transferase
HED66_RS15230	COG2089	acid synthase
HED66_RS15250	COG4310	Domain of unknown function (DUF2172)
HED66_RS15280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HED66_RS15285	COG0745	RESPONSE REGULATOR receiver
HED66_RS15290	COG2205	protein histidine kinase activity
HED66_RS15300	COG0281	malic enzyme
HED66_RS15305	COG0702	epimerase
HED66_RS15310	COG0254	rRNA binding
HED66_RS15315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HED66_RS15325	COG1309	transcriptional regulator
HED66_RS15345	COG0129	dihydroxy-acid dehydratase activity
HED66_RS15355	COG3978	acetolactate synthase activity
HED66_RS15405	COG0204	Acyl-transferase
HED66_RS15420	COG1335	isochorismatase
HED66_RS15430	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HED66_RS15435	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HED66_RS15440	COG3639	organic phosphonate transmembrane transporter activity
HED66_RS15445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HED66_RS15450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HED66_RS15460	COG3084	Protein conserved in bacteria
HED66_RS15465	COG5001	Diguanylate cyclase
HED66_RS15465	COG3706	GGDEF domain
HED66_RS15465	COG4251	negative regulation of phosphorylation
HED66_RS15465	COG2203	Gaf domain
HED66_RS15480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HED66_RS15490	COG1561	YicC-like family, N-terminal region
HED66_RS15520	COG0438	transferase activity, transferring glycosyl groups
HED66_RS15525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HED66_RS15540	COG1063	alcohol dehydrogenase
HED66_RS15555	COG0210	DNA helicase
HED66_RS15560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HED66_RS15565	COG2166	iron-sulfur cluster assembly
HED66_RS15570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HED66_RS15600	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HED66_RS15605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HED66_RS15610	COG1739	Uncharacterized protein family UPF0029
HED66_RS15615	COG0006	proline dipeptidase activity
HED66_RS15620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HED66_RS15625	COG1024	Enoyl-CoA hydratase
HED66_RS15625	COG1250	3-hydroxyacyl-CoA dehydrogenase
HED66_RS15630	COG0183	Belongs to the thiolase family
HED66_RS15635	COG0745	RESPONSE REGULATOR receiver
HED66_RS15640	COG2205	protein histidine kinase activity
HED66_RS15655	COG0425	Belongs to the sulfur carrier protein TusA family
HED66_RS15660	COG0251	oxidation-reduction process
HED66_RS15665	COG2885	chlorophyll binding
HED66_RS15670	COG2818	Glycosylase
HED66_RS15675	COG0752	glycyl-tRNA synthetase alpha subunit
HED66_RS15680	COG0751	glycine-tRNA ligase activity
HED66_RS15690	COG0529	Catalyzes the synthesis of activated sulfate
HED66_RS15700	COG2199	diguanylate cyclase activity
HED66_RS15700	COG2200	EAL domain
HED66_RS15700	COG2202	Pas domain
HED66_RS15715	COG0640	Transcriptional regulator
HED66_RS15725	COG0814	amino acid
HED66_RS15730	COG0348	domain, Protein
HED66_RS15740	COG0446	pyridine nucleotide-disulphide oxidoreductase
HED66_RS15745	COG0426	domain, Protein
HED66_RS15745	COG1773	rubredoxin
HED66_RS15750	COG3604	Transcriptional regulator
HED66_RS15755	COG2188	Transcriptional regulator
HED66_RS15770	COG1609	Transcriptional regulator
HED66_RS15810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HED66_RS15835	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HED66_RS15850	COG3118	belongs to the thioredoxin family
HED66_RS15855	COG0513	Belongs to the DEAD box helicase family
HED66_RS15860	COG0248	Ppx GppA phosphatase
HED66_RS15870	COG0742	ribosomal rna small subunit methyltransferase
HED66_RS15890	COG0084	hydrolase, TatD family'
HED66_RS15895	COG0805	protein transport
HED66_RS15900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HED66_RS15910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HED66_RS15915	COG3165	ubiquinone biosynthetic process from chorismate
HED66_RS15925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HED66_RS15930	COG0402	S-adenosylhomocysteine deaminase activity
HED66_RS15965	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HED66_RS15970	COG0848	biopolymer transport protein
HED66_RS15975	COG0811	peptide transport
HED66_RS15980	COG0811	peptide transport
HED66_RS15990	COG2771	luxR family
HED66_RS15995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HED66_RS16000	COG1349	DNA-binding transcription factor activity
HED66_RS16005	COG0745	RESPONSE REGULATOR receiver
HED66_RS16010	COG2205	protein histidine kinase activity
HED66_RS16020	COG4452	Inner membrane protein CreD
HED66_RS16025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HED66_RS16030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HED66_RS16035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HED66_RS16040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HED66_RS16045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HED66_RS16050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HED66_RS16055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HED66_RS16065	COG0356	it plays a direct role in the translocation of protons across the membrane
HED66_RS16070	COG3312	ion transport
HED66_RS16075	COG1475	DNA binding
HED66_RS16080	COG1192	Involved in chromosome partitioning
HED66_RS16085	COG0357	Ribosomal RNA small subunit methyltransferase G
HED66_RS16090	COG0445	tRNA wobble uridine modification
HED66_RS16095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HED66_RS16100	COG4774	siderophore transport
HED66_RS16105	COG4615	Cyclic peptide transporter
HED66_RS16110	COG1120	ATPase activity
HED66_RS16120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HED66_RS16130	COG4774	siderophore transport
HED66_RS16135	COG4607	ABC-type enterochelin transport system periplasmic component
HED66_RS16140	COG4604	ABC transporter, ATP-binding protein
HED66_RS16145	COG4605	iron ion homeostasis
HED66_RS16150	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HED66_RS16170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED66_RS16180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HED66_RS16185	COG1535	isochorismatase
HED66_RS16185	COG3433	isochorismatase activity
HED66_RS16195	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HED66_RS16200	COG0706	membrane insertase activity
HED66_RS16205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HED66_RS16210	COG0594	ribonuclease P activity
HED66_RS16215	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HED66_RS16235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HED66_RS16240	COG0592	DNA-directed DNA polymerase activity
HED66_RS16260	COG2378	regulation of single-species biofilm formation
HED66_RS16265	COG0071	Belongs to the small heat shock protein (HSP20) family
HED66_RS16270	COG0071	Belongs to the small heat shock protein (HSP20) family
HED66_RS16275	COG3977	Valine--pyruvate aminotransferase
HED66_RS16290	COG2814	Major facilitator Superfamily
HED66_RS16295	COG0745	RESPONSE REGULATOR receiver
HED66_RS16300	COG2205	protein histidine kinase activity
HED66_RS16325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HED66_RS16335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HED66_RS16340	COG4191	Histidine kinase
HED66_RS16340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HED66_RS16345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HED66_RS16350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HED66_RS16355	COG1309	transcriptional regulator
HED66_RS16385	COG0561	phosphatase activity
HED66_RS16390	COG2267	carboxylic ester hydrolase activity
HED66_RS16395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HED66_RS16400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HED66_RS16405	COG1758	RNA polymerase activity
HED66_RS16410	COG0194	GDP metabolic process
HED66_RS16420	COG0859	PFAM glycosyl transferase family 9
HED66_RS16425	COG3642	lipopolysaccharide core region biosynthetic process
HED66_RS16465	COG0589	response to stress
HED66_RS16475	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HED66_RS16480	COG3706	GGDEF domain
HED66_RS16485	COG1528	Iron-storage protein
HED66_RS16490	COG2081	HI0933 family
HED66_RS16500	COG3275	phosphorelay sensor kinase activity
HED66_RS16505	COG3279	Response regulator of the LytR AlgR family
HED66_RS16510	COG2223	nitrite transmembrane transporter activity
HED66_RS16515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HED66_RS16520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HED66_RS16535	COG0583	DNA-binding transcription factor activity
HED66_RS16540	COG4206	TonB-dependent receptor
HED66_RS16545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HED66_RS16590	COG0583	DNA-binding transcription factor activity
HED66_RS16595	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HED66_RS16600	COG0166	Belongs to the GPI family
HED66_RS16610	COG0668	transmembrane transport
HED66_RS16615	COG1309	transcriptional regulator
HED66_RS16620	COG0756	dUTP diphosphatase activity
HED66_RS16625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HED66_RS16630	COG2003	Belongs to the UPF0758 family
HED66_RS16635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HED66_RS16640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HED66_RS16650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HED66_RS16655	COG2990	Protein conserved in bacteria
HED66_RS16660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HED66_RS16665	COG0859	PFAM glycosyl transferase family 9
HED66_RS16670	COG0463	Glycosyl transferase, family 2
HED66_RS16675	COG0859	PFAM glycosyl transferase family 9
HED66_RS16680	COG1519	Transferase
HED66_RS16695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HED66_RS16700	COG1609	Transcriptional regulator
HED66_RS16705	COG0604	alcohol dehydrogenase
HED66_RS16720	COG1580	Controls the rotational direction of flagella during chemotaxis
HED66_RS16725	COG3161	chorismate lyase activity
HED66_RS16730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HED66_RS16735	COG2937	Belongs to the GPAT DAPAT family
HED66_RS16740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HED66_RS16755	COG0534	Mate efflux family protein
HED66_RS16760	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HED66_RS16765	COG2205	protein histidine kinase activity
HED66_RS16770	COG0745	RESPONSE REGULATOR receiver
HED66_RS16780	COG1045	serine acetyltransferase
HED66_RS16790	COG3074	FtsZ-dependent cytokinesis
HED66_RS16795	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HED66_RS16805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HED66_RS16845	COG1609	Transcriptional regulator
HED66_RS16850	COG0385	Bile acid
HED66_RS16855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HED66_RS16875	COG0583	DNA-binding transcription factor activity
HED66_RS16905	COG0210	DNA helicase
HED66_RS16945	COG3161	chorismate lyase activity
HED66_RS16960	COG2823	Periplasmic or secreted lipoprotein
HED66_RS16970	COG1388	LysM domain
HED66_RS16970	COG4641	Protein conserved in bacteria
HED66_RS16985	COG2391	methyltransferase activity
HED66_RS16995	COG1280	lysine exporter protein (LysE YggA)
HED66_RS17005	COG2962	Rard protein
HED66_RS17015	COG1012	belongs to the aldehyde dehydrogenase family
HED66_RS17035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HED66_RS17035	COG0519	Catalyzes the synthesis of GMP from XMP
HED66_RS17040	COG0686	Belongs to the AlaDH PNT family
HED66_RS17045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HED66_RS17070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HED66_RS17075	COG0569	domain protein
HED66_RS17080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HED66_RS17080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HED66_RS17085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HED66_RS17090	COG0242	peptide deformylase activity
HED66_RS17095	COG1652	LysM domain
HED66_RS17100	COG0758	DNA mediated transformation
HED66_RS17105	COG2922	Belongs to the Smg family
HED66_RS17110	COG0551	DNA topoisomerase type I activity
HED66_RS17120	COG0009	L-threonylcarbamoyladenylate synthase
HED66_RS17125	COG0408	coproporphyrinogen oxidase activity
HED66_RS17130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HED66_RS17140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HED66_RS17150	COG3078	GTPase activator activity
HED66_RS17160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HED66_RS17165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HED66_RS17170	COG2204	response regulator
HED66_RS17175	COG3852	Histidine kinase
HED66_RS17185	COG0174	glutamine synthetase
HED66_RS17195	COG1295	ribonuclease BN
HED66_RS17200	COG1490	D-aminoacyl-tRNA deacylase activity
HED66_RS17210	COG0456	acetyltransferase
HED66_RS17220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HED66_RS17225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HED66_RS17230	COG2610	gluconate transmembrane transporter activity
HED66_RS17235	COG3265	gluconokinase activity
HED66_RS17240	COG0129	dihydroxy-acid dehydratase activity
HED66_RS17245	COG0800	Aldolase
HED66_RS17260	COG1609	Transcriptional regulator
HED66_RS17275	COG4942	peptidase
HED66_RS17280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HED66_RS17285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HED66_RS17290	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HED66_RS17295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HED66_RS17300	COG0316	Belongs to the HesB IscA family
HED66_RS17300	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HED66_RS17305	COG1040	competence protein
HED66_RS17310	COG0596	Alpha beta hydrolase
HED66_RS17330	COG2183	response to ionizing radiation
HED66_RS17335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HED66_RS17340	COG0745	RESPONSE REGULATOR receiver
HED66_RS17355	COG0051	transcription antitermination factor activity, RNA binding
HED66_RS17360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HED66_RS17365	COG0088	Forms part of the polypeptide exit tunnel
HED66_RS17370	COG0089	rRNA binding
HED66_RS17375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HED66_RS17380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HED66_RS17385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HED66_RS17390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HED66_RS17395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HED66_RS17400	COG0255	Belongs to the universal ribosomal protein uL29 family
HED66_RS17405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HED66_RS17410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HED66_RS17415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HED66_RS17420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HED66_RS17425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HED66_RS17430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HED66_RS17435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HED66_RS17440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HED66_RS17445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HED66_RS17450	COG1841	ribosomal large subunit assembly
HED66_RS17455	COG0200	Binds to the 23S rRNA
HED66_RS17460	COG0201	protein transport
HED66_RS17465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HED66_RS17470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HED66_RS17475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HED66_RS17480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HED66_RS17485	COG0202	RNA polymerase activity
HED66_RS17490	COG0203	ribosomal protein L17
HED66_RS17545	COG2249	NAD(P)H dehydrogenase (quinone) activity
HED66_RS17560	COG1770	oligopeptidase
HED66_RS17580	COG3714	YhhN family
HED66_RS17605	COG1301	dicarboxylic acid transport
HED66_RS17615	COG2095	MarC family integral membrane protein
HED66_RS17625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HED66_RS17635	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HED66_RS17645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HED66_RS17670	COG0742	ribosomal rna small subunit methyltransferase
HED66_RS17675	COG0552	protein localization to endoplasmic reticulum
HED66_RS17680	COG2884	Cell division ATP-binding protein ftsE
HED66_RS17685	COG2177	Part of the ABC transporter FtsEX involved in
HED66_RS17695	COG0288	reversible hydration of carbon dioxide
HED66_RS17700	COG2188	Transcriptional regulator
HED66_RS17705	COG1228	amidohydrolase
HED66_RS17710	COG0010	Belongs to the arginase family
HED66_RS17715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HED66_RS17720	COG2986	histidine ammonia-lyase
HED66_RS17725	COG0387	Pfam Sodium calcium exchanger
HED66_RS17730	COG2264	protein methyltransferase activity
HED66_RS17735	COG2200	EAL domain
HED66_RS17735	COG2199	diguanylate cyclase activity
HED66_RS17780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HED66_RS17785	COG1459	type II secretion system
HED66_RS17830	COG1077	Cell shape determining protein MreB Mrl
HED66_RS17835	COG1792	Involved in formation and maintenance of cell shape
HED66_RS17840	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HED66_RS17845	COG0424	maF-like protein
HED66_RS17850	COG1530	ribonuclease E activity
HED66_RS17855	COG3164	Protein of unknown function
HED66_RS17865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HED66_RS17870	COG0312	modulator of DNA gyrase
HED66_RS17885	COG0477	Major facilitator Superfamily
HED66_RS17895	COG3437	response regulator, receiver
HED66_RS17900	COG0784	Response regulator, receiver
HED66_RS17900	COG2205	protein histidine kinase activity
HED66_RS17900	COG5002	protein histidine kinase activity
HED66_RS17905	COG2172	sigma factor antagonist activity
HED66_RS17910	COG1366	Belongs to the anti-sigma-factor antagonist family
HED66_RS17920	COG3700	Belongs to the class B bacterial acid phosphatase family
HED66_RS17930	COG1639	'signal transduction protein
HED66_RS17955	COG0189	ligase activity
HED66_RS17960	COG0642	Histidine kinase
HED66_RS17965	COG0745	RESPONSE REGULATOR receiver
HED66_RS17985	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HED66_RS17990	COG0352	thiamine-phosphate diphosphorylase activity
HED66_RS17995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HED66_RS18005	COG2022	thiamine diphosphate biosynthetic process
HED66_RS18025	COG0110	maltose O-acetyltransferase activity
HED66_RS18030	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HED66_RS18045	COG0814	amino acid
HED66_RS18050	COG3932	Exopolysaccharide synthesis, ExoD
HED66_RS18105	COG1494	fructose-1,6-bisphosphatase
HED66_RS18120	COG2959	enzyme of heme biosynthesis
HED66_RS18130	COG0181	hydroxymethylbilane synthase activity
HED66_RS18135	COG3072	Adenylate cyclase
HED66_RS18140	COG0400	carboxylic ester hydrolase activity
HED66_RS18145	COG1965	Belongs to the frataxin family
HED66_RS18155	COG0019	diaminopimelate decarboxylase activity
HED66_RS18160	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HED66_RS18175	COG1011	Hydrolase
HED66_RS18185	COG0668	transmembrane transport
HED66_RS18195	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HED66_RS18200	COG0561	phosphatase activity
HED66_RS18215	COG1129	ABC transporter
HED66_RS18215	COG0842	Transport permease protein
HED66_RS18225	COG1546	Belongs to the CinA family
HED66_RS18225	COG1058	Belongs to the CinA family
HED66_RS18230	COG1418	mRNA catabolic process
HED66_RS18235	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HED66_RS18245	COG1522	sequence-specific DNA binding
HED66_RS18250	COG1368	sulfuric ester hydrolase activity
HED66_RS18270	COG1285	pathogenesis
HED66_RS18290	COG4221	oxidoreductase activity
HED66_RS18310	COG1979	alcohol dehydrogenase
HED66_RS18320	COG2873	o-acetylhomoserine
HED66_RS18335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HED66_RS18350	COG5380	lipid catabolic process
HED66_RS18355	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HED66_RS18365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HED66_RS18370	COG2949	membrane
HED66_RS18375	COG3291	Pkd domain containing protein
HED66_RS18395	COG3188	usher protein
HED66_RS18400	COG3121	Chaperone
HED66_RS18405	COG3539	Fimbrial protein
HED66_RS18420	COG0318	PFAM AMP-dependent synthetase and ligase
HED66_RS18430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HED66_RS18435	COG0596	Alpha beta hydrolase
HED66_RS18440	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HED66_RS18445	COG1169	isochorismate synthase
HED66_RS18450	COG1575	Belongs to the MenA family. Type 1 subfamily
HED66_RS18475	COG0513	Belongs to the DEAD box helicase family
HED66_RS18480	COG1988	membrane-bound metal-dependent
HED66_RS18495	COG1671	Belongs to the UPF0178 family
HED66_RS18515	COG0484	heat shock protein binding
HED66_RS18525	COG3722	fumarate hydratase activity
HED66_RS18530	COG0246	Mannitol dehydrogenase
HED66_RS18535	COG2213	PTS system mannitol-specific
HED66_RS18535	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HED66_RS18550	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HED66_RS18565	COG2771	luxR family
HED66_RS18580	COG3133	Outer membrane lipoprotein
HED66_RS18605	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HED66_RS18610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HED66_RS18630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HED66_RS18635	COG1459	type II secretion system
HED66_RS18640	COG2165	general secretion pathway protein
HED66_RS18650	COG2165	general secretion pathway protein
HED66_RS18655	COG4795	General secretion pathway protein
HED66_RS18660	COG3156	type II secretion system protein K
HED66_RS18670	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HED66_RS18685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HED66_RS18690	COG1011	Hydrolase
HED66_RS18695	COG0494	nUDIX hydrolase
HED66_RS18700	COG1218	3'(2'),5'-bisphosphate nucleotidase
HED66_RS18705	COG0814	amino acid
HED66_RS18710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HED66_RS18725	COG0626	cystathionine gamma-synthase activity
HED66_RS18730	COG0460	homoserine dehydrogenase
HED66_RS18730	COG0527	aspartate kinase activity
HED66_RS18745	COG1346	cytolysis
HED66_RS18750	COG1380	Effector of murein hydrolase LrgA
HED66_RS18755	COG0583	DNA-binding transcription factor activity
HED66_RS18790	COG0589	response to stress
HED66_RS18795	COG0659	secondary active sulfate transmembrane transporter activity
HED66_RS18800	COG1546	Belongs to the CinA family
HED66_RS18805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HED66_RS18815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HED66_RS18820	COG0527	aspartate kinase activity
HED66_RS18825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HED66_RS18860	COG1686	Belongs to the peptidase S11 family
HED66_RS18865	COG0586	Pfam SNARE associated Golgi protein
HED66_RS18870	COG1253	flavin adenine dinucleotide binding
HED66_RS18880	COG2927	DNA polymerase III (CHI subunit)
HED66_RS18885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HED66_RS18890	COG0795	lipopolysaccharide-transporting ATPase activity
HED66_RS18895	COG0795	lipopolysaccharide-transporting ATPase activity
HED66_RS18910	COG0004	ammonium transporteR
HED66_RS18915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HED66_RS18935	COG0084	hydrolase, TatD family'
HED66_RS18940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HED66_RS18950	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HED66_RS18955	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HED66_RS18960	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HED66_RS18965	COG0813	purine-nucleoside phosphorylase activity
HED66_RS18975	COG0560	Phosphoserine phosphatase
HED66_RS19000	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HED66_RS19005	COG0776	regulation of translation
HED66_RS19020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HED66_RS19025	COG0735	belongs to the Fur family
HED66_RS19045	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HED66_RS19050	COG0513	Belongs to the DEAD box helicase family
HED66_RS19055	COG3022	response to hydroperoxide
HED66_RS19070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HED66_RS19075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HED66_RS19080	COG0762	integral membrane protein
HED66_RS19085	COG1872	DUF167
HED66_RS19100	COG4166	transmembrane transport
HED66_RS19110	COG0110	maltose O-acetyltransferase activity
HED66_RS19120	COG1024	Enoyl-CoA hydratase
HED66_RS19135	COG4221	oxidoreductase activity
HED66_RS19145	COG2957	Belongs to the agmatine deiminase family
HED66_RS19175	COG0513	Belongs to the DEAD box helicase family
HED66_RS19195	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HED66_RS19260	COG2816	NAD+ diphosphatase activity
HED66_RS19265	COG2205	protein histidine kinase activity
HED66_RS19270	COG0745	RESPONSE REGULATOR receiver
HED66_RS19275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HED66_RS19280	COG1136	(ABC) transporter
HED66_RS19280	COG0577	efflux transmembrane transporter activity
HED66_RS19285	COG1505	serine-type exopeptidase activity
HED66_RS19290	COG2982	Protein involved in outer membrane biogenesis
HED66_RS19300	COG1028	Short-chain dehydrogenase reductase Sdr
HED66_RS19315	COG3730	PTS system glucitol sorbitol-specific
HED66_RS19330	COG1028	Short-chain dehydrogenase reductase Sdr
HED66_RS19340	COG1349	DNA-binding transcription factor activity
HED66_RS19345	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HED66_RS19365	COG2130	NADP-dependent
HED66_RS19370	COG1764	response to oxidative stress
HED66_RS19375	COG1846	Transcriptional regulator
HED66_RS19405	COG0561	phosphatase activity
HED66_RS19420	COG0733	neurotransmitter:sodium symporter activity
HED66_RS19430	COG0733	neurotransmitter:sodium symporter activity
HED66_RS19455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HED66_RS19470	COG1794	racemase activity, acting on amino acids and derivatives
HED66_RS19480	COG2731	YhcH YjgK YiaL family protein
HED66_RS19490	COG0668	transmembrane transport
HED66_RS19495	COG1376	ErfK ybiS ycfS ynhG family protein
HED66_RS19500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HED66_RS19515	COG0789	Transcriptional regulator
HED66_RS19550	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HED66_RS19560	COG0488	(ABC) transporter
HED66_RS19565	COG0517	IMP dehydrogenase activity
HED66_RS19565	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HED66_RS19570	COG1585	Membrane protein implicated in regulation of membrane protease activity
HED66_RS19575	COG0330	HflC and HflK could
HED66_RS19580	COG1648	precorrin-2 dehydrogenase activity
HED66_RS19580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HED66_RS19585	COG0175	sulfate reduction
HED66_RS19590	COG2895	sulfate adenylyltransferase (ATP) activity
HED66_RS19595	COG0471	metal ion transport
HED66_RS19595	COG3273	potassium ion transport
HED66_RS19600	COG0529	Catalyzes the synthesis of activated sulfate
HED66_RS19615	COG0840	transmembrane signaling receptor activity
HED66_RS19635	COG1136	(ABC) transporter
HED66_RS19650	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HED66_RS19665	COG1940	carbohydrate kinase activity
HED66_RS19670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HED66_RS19675	COG0126	phosphoglycerate kinase activity
HED66_RS19680	COG0191	fructose-bisphosphate aldolase activity
HED66_RS19685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HED66_RS19735	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HED66_RS19740	COG1595	DNA-templated transcription, initiation
HED66_RS19745	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HED66_RS19760	COG0481	GTPase activity
HED66_RS19770	COG0571	ribonuclease III activity
HED66_RS19780	COG1381	Involved in DNA repair and RecF pathway recombination
HED66_RS19785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HED66_RS19800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HED66_RS19805	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HED66_RS19810	COG3716	PTS system mannose fructose sorbose family IID component
HED66_RS19820	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HED66_RS19825	COG2222	sugar isomerase
HED66_RS19835	COG1349	DNA-binding transcription factor activity
HED66_RS19840	COG3023	N-Acetylmuramoyl-L-alanine amidase
HED66_RS19845	COG4807	Protein conserved in bacteria
HED66_RS19855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HED66_RS19860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HED66_RS19865	COG3956	TIGRFAM MazG family protein
HED66_RS19870	COG0504	CTP synthase activity
HED66_RS19875	COG0148	phosphopyruvate hydratase activity
HED66_RS19880	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HED66_RS19885	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HED66_RS19895	COG0585	pseudouridine synthase activity
HED66_RS19900	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HED66_RS19905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HED66_RS19910	COG1238	metal cluster binding
HED66_RS19915	COG4942	peptidase
HED66_RS19915	COG1388	LysM domain
HED66_RS19925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HED66_RS19930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HED66_RS19935	COG1610	YqeY-like protein
HED66_RS19940	COG0358	DNA primase activity
HED66_RS19945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HED66_RS19975	COG0151	Belongs to the GarS family
HED66_RS19980	COG0138	bifunctional purine biosynthesis protein purh
HED66_RS19990	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HED66_RS19995	COG3036	rescue of stalled ribosome
HED66_RS20000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HED66_RS20005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HED66_RS20015	COG0673	inositol 2-dehydrogenase activity
HED66_RS20030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HED66_RS20035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HED66_RS20040	COG3227	Zinc metalloprotease (Elastase)
HED66_RS20050	COG0477	Major facilitator Superfamily
HED66_RS20055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HED66_RS20060	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HED66_RS20065	COG1027	Aspartate ammonia-lyase
HED66_RS20070	COG3030	protein affecting phage T7 exclusion by the F plasmid
HED66_RS20075	COG0534	Mate efflux family protein
HED66_RS20080	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HED66_RS20085	COG0459	protein refolding
HED66_RS20095	COG5001	Diguanylate cyclase
HED66_RS20095	COG3300	MHYT domain
HED66_RS20105	COG0564	pseudouridine synthase activity
HED66_RS20110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HED66_RS20135	COG1280	lysine exporter protein (LysE YggA)
HED66_RS20140	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HED66_RS20155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HED66_RS20185	COG0471	metal ion transport
HED66_RS20200	COG0745	RESPONSE REGULATOR receiver
HED66_RS20205	COG3104	oligopeptide transport
HED66_RS20210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HED66_RS20215	COG1555	photosystem II stabilization
HED66_RS20225	COG2350	Protein conserved in bacteria
HED66_RS20230	COG2917	probably involved in intracellular septation
HED66_RS20235	COG0076	glutamate decarboxylase activity
HED66_RS20240	COG1272	protein, Hemolysin III
HED66_RS20245	COG2985	domain, Protein
HED66_RS20245	COG0569	domain protein
HED66_RS20320	COG0835	chemotaxis
HED66_RS20320	COG0784	Response regulator, receiver
HED66_RS20325	COG2755	lipolytic protein G-D-S-L family
HED66_RS20330	COG4181	ATPase activity
HED66_RS20335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HED66_RS20340	COG1090	epimerase
HED66_RS20345	COG2200	EAL domain
HED66_RS20350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HED66_RS20355	COG2234	aminopeptidase activity
HED66_RS20355	COG4935	Belongs to the peptidase S8 family
HED66_RS20360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HED66_RS20365	COG3171	Protein conserved in bacteria
HED66_RS20370	COG2066	Belongs to the glutaminase family
HED66_RS20375	COG2897	thiosulfate sulfurtransferase activity
HED66_RS20385	COG1132	(ABC) transporter
HED66_RS20395	COG1309	transcriptional regulator
HED66_RS20400	COG1012	belongs to the aldehyde dehydrogenase family
HED66_RS20405	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HED66_RS20430	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HED66_RS20455	COG4628	conserved protein (DUF2132)
HED66_RS20460	COG0688	phosphatidylethanolamine metabolic process
HED66_RS20470	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HED66_RS20510	COG1278	Cold shock
HED66_RS20520	COG0840	transmembrane signaling receptor activity
HED66_RS20525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HED66_RS20575	COG0848	biopolymer transport protein
HED66_RS20580	COG0811	peptide transport
HED66_RS20585	COG0811	peptide transport
HED66_RS20595	COG4206	TonB-dependent receptor
HED66_RS20600	COG4174	ABC transporter (Permease)
HED66_RS20605	COG4239	(ABC) transporter, permease
HED66_RS20610	COG0747	negative chemotaxis
HED66_RS20615	COG0444	Belongs to the ABC transporter superfamily
HED66_RS20620	COG4608	Belongs to the ABC transporter superfamily
HED66_RS20625	COG2195	Cleaves the N-terminal amino acid of tripeptides
HED66_RS20635	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HED66_RS20650	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HED66_RS20655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HED66_RS20680	COG0243	molybdopterin cofactor binding
HED66_RS20695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HED66_RS20695	COG1116	anion transmembrane transporter activity
HED66_RS20700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HED66_RS20705	COG1116	anion transmembrane transporter activity
HED66_RS20710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HED66_RS20710	COG2146	nitrite reductase [NAD(P)H] activity
HED66_RS20715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HED66_RS20715	COG2146	nitrite reductase [NAD(P)H] activity
HED66_RS20720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HED66_RS20725	COG2313	pseudouridylate synthase activity
HED66_RS20735	COG1858	cytochrome C peroxidase
HED66_RS20770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HED66_RS20775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HED66_RS20785	COG0318	PFAM AMP-dependent synthetase and ligase
HED66_RS20790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HED66_RS20800	COG2986	histidine ammonia-lyase
HED66_RS20825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HED66_RS20835	COG1028	Short-chain dehydrogenase reductase Sdr
HED66_RS20840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HED66_RS20850	COG0521	Mo-molybdopterin cofactor biosynthetic process
HED66_RS20860	COG2966	Psort location CytoplasmicMembrane, score
HED66_RS20865	COG3610	response to peptide
HED66_RS20880	COG4176	ABC-type proline glycine betaine transport system permease component
HED66_RS20885	COG2113	Glycine betaine
HED66_RS20890	COG0175	sulfate reduction
HED66_RS20895	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HED66_RS20900	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HED66_RS20905	COG0384	phenazine biosynthesis protein PhzF
HED66_RS20910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HED66_RS20925	COG0786	glutamate:sodium symporter activity
HED66_RS20930	COG0252	asparaginase activity
HED66_RS20935	COG3139	Protein of unknown function (DUF1315)
HED66_RS20955	COG0616	signal peptide processing
HED66_RS20960	COG1902	pentaerythritol trinitrate reductase activity
HED66_RS20960	COG0446	pyridine nucleotide-disulphide oxidoreductase
HED66_RS20965	COG0778	Nitroreductase
HED66_RS20980	COG4302	ethanolamine ammonia-lyase activity
HED66_RS20985	COG4303	Ethanolamine ammonia lyase large subunit
HED66_RS20990	COG0531	amino acid
HED66_RS20995	COG2264	protein methyltransferase activity
HED66_RS21000	COG0604	alcohol dehydrogenase
HED66_RS21005	COG0583	DNA-binding transcription factor activity
HED66_RS21010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HED66_RS21010	COG1263	PTS System
HED66_RS21010	COG2190	(PTS) system
HED66_RS21015	COG4145	pantothenate transmembrane transporter activity
HED66_RS21020	COG3924	membrane
HED66_RS21025	COG0439	Biotin carboxylase
HED66_RS21030	COG0511	ligase activity, forming carbon-carbon bonds
HED66_RS21035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HED66_RS21040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HED66_RS21070	COG3381	protein complex oligomerization
HED66_RS21080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HED66_RS21095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HED66_RS21100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HED66_RS21100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HED66_RS21115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HED66_RS21120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HED66_RS21125	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HED66_RS21130	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HED66_RS21135	COG4172	Belongs to the ABC transporter superfamily
HED66_RS21140	COG0747	negative chemotaxis
HED66_RS21155	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HED66_RS21160	COG0142	geranyltranstransferase activity
HED66_RS21165	COG1722	exodeoxyribonuclease VII activity
HED66_RS21170	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HED66_RS21175	COG1360	Flagellar Motor Protein
HED66_RS21190	COG1534	Rna-binding protein
HED66_RS21195	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HED66_RS21205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HED66_RS21210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HED66_RS21215	COG0149	triose-phosphate isomerase activity
HED66_RS21220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HED66_RS21235	COG0779	Required for maturation of 30S ribosomal subunits
HED66_RS21240	COG0195	Participates in both transcription termination and antitermination