locus-tag	class	description
E5E96_RS00015	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E5E96_RS00035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_RS00040	COG1309	transcriptional regulator
E5E96_RS00060	COG1946	Acyl-CoA thioesterase
E5E96_RS00070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5E96_RS00080	COG0009	L-threonylcarbamoyladenylate synthase
E5E96_RS00090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5E96_RS00095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5E96_RS00095	COG0512	Glutamine amidotransferase of anthranilate synthase
E5E96_RS00100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5E96_RS00105	COG0134	indole-3-glycerol-phosphate synthase activity
E5E96_RS00105	COG0135	phosphoribosylanthranilate isomerase activity
E5E96_RS00110	COG0133	tryptophan synthase activity
E5E96_RS00115	COG0159	tryptophan synthase activity
E5E96_RS00140	COG1988	membrane-bound metal-dependent
E5E96_RS00160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E96_RS00175	COG3152	Membrane
E5E96_RS00190	COG2814	Major facilitator Superfamily
E5E96_RS00195	COG0109	protoheme IX farnesyltransferase activity
E5E96_RS00200	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E5E96_RS00205	COG1845	cytochrome c oxidase, subunit III
E5E96_RS00210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5E96_RS00215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5E96_RS00275	COG0708	Exodeoxyribonuclease III
E5E96_RS00295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_RS00300	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E96_RS00320	COG0095	Lipoate-protein ligase
E5E96_RS00350	COG0640	Transcriptional regulator
E5E96_RS00365	COG1285	pathogenesis
E5E96_RS00370	COG0484	heat shock protein binding
E5E96_RS00375	COG0443	Heat shock 70 kDa protein
E5E96_RS00380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5E96_RS00385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5E96_RS00395	COG1227	inorganic diphosphatase activity
E5E96_RS00405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_RS00410	COG0577	efflux transmembrane transporter activity
E5E96_RS00410	COG1136	(ABC) transporter
E5E96_RS00420	COG2375	cellular response to nickel ion
E5E96_RS00425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E96_RS00450	COG3152	Membrane
E5E96_RS00465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E96_RS00470	COG1917	Cupin 2, conserved barrel domain protein
E5E96_RS00470	COG1396	sequence-specific DNA binding
E5E96_RS00485	COG0531	amino acid
E5E96_RS00495	COG0531	amino acid
E5E96_RS00505	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5E96_RS00515	COG3384	dioxygenase
E5E96_RS00520	COG2205	protein histidine kinase activity
E5E96_RS00520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_RS00535	COG0813	purine-nucleoside phosphorylase activity
E5E96_RS00580	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5E96_RS00585	COG0083	homoserine kinase activity
E5E96_RS00595	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E5E96_RS00600	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E5E96_RS00615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5E96_RS00625	COG0745	RESPONSE REGULATOR receiver
E5E96_RS00640	COG4988	ABC transporter
E5E96_RS00645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E5E96_RS00665	COG1720	tRNA m6t6A37 methyltransferase activity
E5E96_RS00680	COG0542	response to heat
E5E96_RS00685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5E96_RS00690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_RS00700	COG2190	(PTS) system
E5E96_RS00715	COG3038	cytochrome b561
E5E96_RS00730	COG0419	ATPase involved in DNA repair
E5E96_RS00735	COG0420	3'-5' exonuclease activity
E5E96_RS00745	COG2974	May be involved in recombination
E5E96_RS00755	COG4651	solute:proton antiporter activity
E5E96_RS00755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5E96_RS00770	COG0469	pyruvate kinase activity
E5E96_RS00775	COG3264	Mechanosensitive ion channel
E5E96_RS00775	COG1196	nuclear chromosome segregation
E5E96_RS00785	COG2706	6-phosphogluconolactonase activity
E5E96_RS00795	COG0281	malic enzyme
E5E96_RS00810	COG0437	4 iron, 4 sulfur cluster binding
E5E96_RS00815	COG3383	formate dehydrogenase (NAD+) activity
E5E96_RS00815	COG3383	formate dehydrogenase (NAD+) activity
E5E96_RS00845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5E96_RS00855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5E96_RS00860	COG1910	domain protein
E5E96_RS00865	COG3852	Histidine kinase
E5E96_RS00870	COG2204	response regulator
E5E96_RS00880	COG4662	Binding-protein-dependent transport system inner membrane component
E5E96_RS00890	COG0746	molybdenum cofactor guanylyltransferase activity
E5E96_RS00895	COG0303	'Molybdopterin
E5E96_RS00900	COG1289	transmembrane transporter activity
E5E96_RS00930	COG3220	belongs to the UPF0276 family
E5E96_RS00960	COG2205	protein histidine kinase activity
E5E96_RS00960	COG0784	Response regulator, receiver
E5E96_RS00965	COG4166	transmembrane transport
E5E96_RS00970	COG0601	transmembrane transport
E5E96_RS00975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5E96_RS00980	COG0444	Belongs to the ABC transporter superfamily
E5E96_RS00985	COG4608	Belongs to the ABC transporter superfamily
E5E96_RS00995	COG2971	BadF BadG BcrA BcrD
E5E96_RS01005	COG0840	transmembrane signaling receptor activity
E5E96_RS01025	COG3724	N-succinylarginine dihydrolase activity
E5E96_RS01030	COG0616	signal peptide processing
E5E96_RS01035	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_RS01040	COG0583	DNA-binding transcription factor activity
E5E96_RS01050	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5E96_RS01060	COG0583	DNA-binding transcription factor activity
E5E96_RS01070	COG1881	PFAM PEBP family protein
E5E96_RS01080	COG3408	Glycogen debranching enzyme
E5E96_RS01080	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E5E96_RS01085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5E96_RS01090	COG0739	heme binding
E5E96_RS01095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E5E96_RS01115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5E96_RS01125	COG3091	SprT-like family
E5E96_RS01135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5E96_RS01140	COG0189	ligase activity
E5E96_RS01150	COG1678	Uncharacterized ACR, COG1678
E5E96_RS01155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5E96_RS01160	COG3104	oligopeptide transport
E5E96_RS01170	COG0714	Associated with various cellular activities
E5E96_RS01185	COG1115	amino acid carrier protein
E5E96_RS01190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5E96_RS01205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5E96_RS01215	COG1301	dicarboxylic acid transport
E5E96_RS01225	COG2912	Transglutaminase-like superfamily
E5E96_RS01235	COG2890	protein-(glutamine-N5) methyltransferase activity
E5E96_RS01240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5E96_RS01245	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5E96_RS01250	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E5E96_RS01255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E5E96_RS01265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5E96_RS01270	COG0737	Belongs to the 5'-nucleotidase family
E5E96_RS01275	COG0193	aminoacyl-tRNA hydrolase activity
E5E96_RS01280	COG0012	GTP binding
E5E96_RS01325	COG0490	domain, Protein
E5E96_RS01325	COG0471	metal ion transport
E5E96_RS01355	COG2214	Heat shock protein DnaJ domain protein
E5E96_RS01370	COG0366	Alpha amylase catalytic
E5E96_RS01380	COG1013	pyruvate-flavodoxin oxidoreductase activity
E5E96_RS01380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_RS01380	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5E96_RS01380	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5E96_RS01390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E96_RS01400	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_RS01410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5E96_RS01425	COG0180	Tryptophanyl-tRNA synthetase
E5E96_RS01435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5E96_RS01445	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E5E96_RS01455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E5E96_RS01460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5E96_RS01495	COG0583	DNA-binding transcription factor activity
E5E96_RS01515	COG0583	DNA-binding transcription factor activity
E5E96_RS01530	COG0739	heme binding
E5E96_RS01545	COG0584	glycerophosphoryl diester phosphodiesterase
E5E96_RS01555	COG1053	succinate dehydrogenase
E5E96_RS01560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5E96_RS01565	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
E5E96_RS01590	COG3214	Protein conserved in bacteria
E5E96_RS01625	COG0745	RESPONSE REGULATOR receiver
E5E96_RS01630	COG0642	Histidine kinase
E5E96_RS01650	COG0516	GMP reductase activity
E5E96_RS01660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5E96_RS01665	COG3647	Membrane
E5E96_RS01675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5E96_RS01685	COG3706	GGDEF domain
E5E96_RS01695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E96_RS01705	COG0583	DNA-binding transcription factor activity
E5E96_RS01710	COG3706	GGDEF domain
E5E96_RS01720	COG1335	isochorismatase
E5E96_RS01725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5E96_RS01730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5E96_RS01735	COG1702	phosphate starvation-inducible protein PhoH
E5E96_RS01740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5E96_RS01745	COG4535	Mg2 and Co2 transporter CorC
E5E96_RS01750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E5E96_RS01755	COG2888	peptidyl-tyrosine sulfation
E5E96_RS01760	COG0495	leucyl-tRNA aminoacylation
E5E96_RS01775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5E96_RS01780	COG0799	negative regulation of ribosome biogenesis
E5E96_RS01785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5E96_RS01790	COG0768	penicillin binding
E5E96_RS01795	COG0772	Belongs to the SEDS family
E5E96_RS01800	COG0772	Belongs to the SEDS family
E5E96_RS01805	COG2951	lytic endotransglycosylase activity
E5E96_RS01810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E5E96_RS01815	COG1686	Belongs to the peptidase S11 family
E5E96_RS01820	COG2921	Belongs to the UPF0250 family
E5E96_RS01825	COG0321	lipoyl(octanoyl) transferase activity
E5E96_RS01830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5E96_RS01840	COG3545	Serine hydrolase
E5E96_RS01845	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E96_RS01860	COG0789	Transcriptional regulator
E5E96_RS01870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5E96_RS01875	COG1970	mechanosensitive ion channel activity
E5E96_RS01880	COG3706	GGDEF domain
E5E96_RS01885	COG4974	Belongs to the 'phage' integrase family
E5E96_RS01895	COG0312	modulator of DNA gyrase
E5E96_RS01900	COG0312	modulator of DNA gyrase
E5E96_RS01965	COG3275	phosphorelay sensor kinase activity
E5E96_RS01970	COG3279	Response regulator of the LytR AlgR family
E5E96_RS01975	COG1966	Carbon starvation protein
E5E96_RS01985	COG0114	fumarate hydratase activity
E5E96_RS01995	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E5E96_RS02005	COG2211	Major facilitator Superfamily
E5E96_RS02010	COG1185	polyribonucleotide nucleotidyltransferase activity
E5E96_RS02015	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5E96_RS02020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5E96_RS02025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5E96_RS02030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5E96_RS02035	COG0195	Participates in both transcription termination and antitermination
E5E96_RS02040	COG0779	Required for maturation of 30S ribosomal subunits
E5E96_RS02055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5E96_RS02060	COG0149	triose-phosphate isomerase activity
E5E96_RS02065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5E96_RS02070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5E96_RS02080	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E5E96_RS02085	COG1534	Rna-binding protein
E5E96_RS02100	COG1360	Flagellar Motor Protein
E5E96_RS02105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5E96_RS02110	COG1722	exodeoxyribonuclease VII activity
E5E96_RS02115	COG0142	geranyltranstransferase activity
E5E96_RS02120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5E96_RS02140	COG4172	Belongs to the ABC transporter superfamily
E5E96_RS02145	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5E96_RS02150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E5E96_RS02155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5E96_RS02160	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5E96_RS02180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5E96_RS02180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5E96_RS02185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5E96_RS02195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5E96_RS02210	COG3381	protein complex oligomerization
E5E96_RS02230	COG3300	MHYT domain
E5E96_RS02230	COG5001	Diguanylate cyclase
E5E96_RS02240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5E96_RS02245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E5E96_RS02250	COG0511	ligase activity, forming carbon-carbon bonds
E5E96_RS02255	COG0439	Biotin carboxylase
E5E96_RS02265	COG4145	pantothenate transmembrane transporter activity
E5E96_RS02270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_RS02270	COG2190	(PTS) system
E5E96_RS02270	COG1263	PTS System
E5E96_RS02275	COG0583	DNA-binding transcription factor activity
E5E96_RS02280	COG0604	alcohol dehydrogenase
E5E96_RS02285	COG2264	protein methyltransferase activity
E5E96_RS02300	COG0778	Nitroreductase
E5E96_RS02310	COG0616	signal peptide processing
E5E96_RS02330	COG3139	Protein of unknown function (DUF1315)
E5E96_RS02335	COG0252	asparaginase activity
E5E96_RS02340	COG0786	glutamate:sodium symporter activity
E5E96_RS02355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E5E96_RS02360	COG0384	phenazine biosynthesis protein PhzF
E5E96_RS02365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5E96_RS02370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5E96_RS02375	COG0175	sulfate reduction
E5E96_RS02380	COG2113	Glycine betaine
E5E96_RS02385	COG4176	ABC-type proline glycine betaine transport system permease component
E5E96_RS02390	COG4175	Glycine betaine
E5E96_RS02400	COG3610	response to peptide
E5E96_RS02405	COG2966	Psort location CytoplasmicMembrane, score
E5E96_RS02415	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5E96_RS02425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5E96_RS02430	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_RS02440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5E96_RS02475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5E96_RS02490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5E96_RS02495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5E96_RS02530	COG1858	cytochrome C peroxidase
E5E96_RS02540	COG2313	pseudouridylate synthase activity
E5E96_RS02545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E96_RS02575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5E96_RS02595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E5E96_RS02600	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5E96_RS02605	COG4608	Belongs to the ABC transporter superfamily
E5E96_RS02610	COG0444	Belongs to the ABC transporter superfamily
E5E96_RS02620	COG4239	(ABC) transporter, permease
E5E96_RS02625	COG4174	ABC transporter (Permease)
E5E96_RS02640	COG0811	peptide transport
E5E96_RS02645	COG0811	peptide transport
E5E96_RS02650	COG0848	biopolymer transport protein
E5E96_RS02700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5E96_RS02705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5E96_RS02710	COG0840	transmembrane signaling receptor activity
E5E96_RS02720	COG1278	Cold shock
E5E96_RS02760	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5E96_RS02765	COG1162	GTPase activity
E5E96_RS02770	COG0688	phosphatidylethanolamine metabolic process
E5E96_RS02775	COG4628	conserved protein (DUF2132)
E5E96_RS02790	COG3059	membrane
E5E96_RS02795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5E96_RS02810	COG3300	MHYT domain
E5E96_RS02810	COG5001	Diguanylate cyclase
E5E96_RS02815	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E5E96_RS02845	COG1132	(ABC) transporter
E5E96_RS02855	COG1404	Belongs to the peptidase S8 family
E5E96_RS02860	COG2897	thiosulfate sulfurtransferase activity
E5E96_RS02865	COG2066	Belongs to the glutaminase family
E5E96_RS02870	COG3171	Protein conserved in bacteria
E5E96_RS02875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5E96_RS02880	COG4935	Belongs to the peptidase S8 family
E5E96_RS02880	COG2234	aminopeptidase activity
E5E96_RS02885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5E96_RS02890	COG2200	EAL domain
E5E96_RS02895	COG1090	epimerase
E5E96_RS02900	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E5E96_RS02905	COG4181	ATPase activity
E5E96_RS02910	COG2755	lipolytic protein G-D-S-L family
E5E96_RS02915	COG0784	Response regulator, receiver
E5E96_RS02915	COG0835	chemotaxis
E5E96_RS02925	COG0569	domain protein
E5E96_RS02925	COG2985	domain, Protein
E5E96_RS02930	COG1272	protein, Hemolysin III
E5E96_RS02935	COG0076	glutamate decarboxylase activity
E5E96_RS02940	COG2917	probably involved in intracellular septation
E5E96_RS02945	COG2350	Protein conserved in bacteria
E5E96_RS02955	COG1555	photosystem II stabilization
E5E96_RS02960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5E96_RS02965	COG3104	oligopeptide transport
E5E96_RS02970	COG0745	RESPONSE REGULATOR receiver
E5E96_RS03005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_RS03020	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E5E96_RS03025	COG1280	lysine exporter protein (LysE YggA)
E5E96_RS03050	COG0316	Belongs to the HesB IscA family
E5E96_RS03060	COG0038	chloride channel
E5E96_RS03065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5E96_RS03080	COG0671	phosphoesterase, PA-phosphatase related
E5E96_RS03090	COG0784	Response regulator, receiver
E5E96_RS03090	COG3437	response regulator, receiver
E5E96_RS03100	COG2076	Multidrug Resistance protein
E5E96_RS03110	COG0346	lactoylglutathione lyase activity
E5E96_RS03115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5E96_RS03120	COG1643	Atp-dependent helicase
E5E96_RS03130	COG1489	DNA binding
E5E96_RS03135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E5E96_RS03140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5E96_RS03155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E5E96_RS03160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E5E96_RS03180	COG1924	4 iron, 4 sulfur cluster binding
E5E96_RS03185	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E5E96_RS03190	COG0842	Transport permease protein
E5E96_RS03195	COG1131	(ABC) transporter
E5E96_RS03210	COG0163	prenyltransferase activity
E5E96_RS03215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5E96_RS03220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5E96_RS03235	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E5E96_RS03250	COG1136	(ABC) transporter
E5E96_RS03270	COG0840	transmembrane signaling receptor activity
E5E96_RS03295	COG0529	Catalyzes the synthesis of activated sulfate
E5E96_RS03300	COG3273	potassium ion transport
E5E96_RS03300	COG0471	metal ion transport
E5E96_RS03305	COG2895	sulfate adenylyltransferase (ATP) activity
E5E96_RS03310	COG0175	sulfate reduction
E5E96_RS03315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5E96_RS03315	COG1648	precorrin-2 dehydrogenase activity
E5E96_RS03320	COG0330	HflC and HflK could
E5E96_RS03325	COG1585	Membrane protein implicated in regulation of membrane protease activity
E5E96_RS03330	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5E96_RS03330	COG0517	IMP dehydrogenase activity
E5E96_RS03335	COG0488	(ABC) transporter
E5E96_RS03345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5E96_RS03350	COG0583	DNA-binding transcription factor activity
E5E96_RS03385	COG0789	Transcriptional regulator
E5E96_RS03390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5E96_RS03400	COG0668	transmembrane transport
E5E96_RS03410	COG2731	YhcH YjgK YiaL family protein
E5E96_RS03425	COG1794	racemase activity, acting on amino acids and derivatives
E5E96_RS03440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5E96_RS03465	COG0733	neurotransmitter:sodium symporter activity
E5E96_RS03475	COG0733	neurotransmitter:sodium symporter activity
E5E96_RS03490	COG0561	phosphatase activity
E5E96_RS03520	COG1846	Transcriptional regulator
E5E96_RS03525	COG1764	response to oxidative stress
E5E96_RS03530	COG2130	NADP-dependent
E5E96_RS03535	COG1051	belongs to the nudix hydrolase family
E5E96_RS03555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5E96_RS03560	COG1640	4-alpha-glucanotransferase
E5E96_RS03565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5E96_RS03570	COG0676	glucose-6-phosphate 1-epimerase activity
E5E96_RS03575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5E96_RS03580	COG0840	transmembrane signaling receptor activity
E5E96_RS03655	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E5E96_RS03660	COG2885	chlorophyll binding
E5E96_RS03665	COG0823	Involved in the tonB-independent uptake of proteins
E5E96_RS03680	COG0811	peptide transport
E5E96_RS03685	COG0824	Thioesterase
E5E96_RS03690	COG3790	cyd operon protein YbgE
E5E96_RS03695	COG4890	Cyd operon protein YbgT
E5E96_RS03700	COG1294	oxidase, subunit
E5E96_RS03705	COG1271	oxidase subunit
E5E96_RS03710	COG2255	four-way junction helicase activity
E5E96_RS03715	COG0632	four-way junction helicase activity
E5E96_RS03720	COG0840	transmembrane signaling receptor activity
E5E96_RS03725	COG0442	prolyl-tRNA aminoacylation
E5E96_RS03730	COG4221	oxidoreductase activity
E5E96_RS03745	COG1024	Enoyl-CoA hydratase
E5E96_RS03765	COG4166	transmembrane transport
E5E96_RS03780	COG1872	DUF167
E5E96_RS03785	COG0762	integral membrane protein
E5E96_RS03790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E5E96_RS03795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E5E96_RS03810	COG3022	response to hydroperoxide
E5E96_RS03815	COG0513	Belongs to the DEAD box helicase family
E5E96_RS03820	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E5E96_RS03845	COG0735	belongs to the Fur family
E5E96_RS03850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5E96_RS03865	COG0776	regulation of translation
E5E96_RS03875	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E5E96_RS03900	COG0560	Phosphoserine phosphatase
E5E96_RS03910	COG3447	MASE1 domain protein
E5E96_RS03910	COG5001	Diguanylate cyclase
E5E96_RS03910	COG5002	protein histidine kinase activity
E5E96_RS03915	COG0813	purine-nucleoside phosphorylase activity
E5E96_RS03920	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E5E96_RS03925	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E5E96_RS03930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E5E96_RS03940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E96_RS03945	COG0084	hydrolase, TatD family'
E5E96_RS03960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5E96_RS03965	COG0004	ammonium transporteR
E5E96_RS03980	COG0795	lipopolysaccharide-transporting ATPase activity
E5E96_RS03985	COG0795	lipopolysaccharide-transporting ATPase activity
E5E96_RS03990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5E96_RS03995	COG2927	DNA polymerase III (CHI subunit)
E5E96_RS04000	COG0525	valine-tRNA ligase activity
E5E96_RS04005	COG1253	flavin adenine dinucleotide binding
E5E96_RS04010	COG0586	Pfam SNARE associated Golgi protein
E5E96_RS04015	COG1686	Belongs to the peptidase S11 family
E5E96_RS04050	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E5E96_RS04055	COG0527	aspartate kinase activity
E5E96_RS04060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5E96_RS04070	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5E96_RS04075	COG1546	Belongs to the CinA family
E5E96_RS04080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5E96_RS04100	COG3068	Protein conserved in bacteria
E5E96_RS04110	COG0739	heme binding
E5E96_RS04130	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E5E96_RS04135	COG1121	(ABC) transporter
E5E96_RS04140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5E96_RS04145	COG0583	DNA-binding transcription factor activity
E5E96_RS04150	COG0697	spore germination
E5E96_RS04155	COG1573	uracil-dna glycosylase
E5E96_RS04160	COG2962	Rard protein
E5E96_RS04170	COG2827	Endonuclease containing a URI domain
E5E96_RS04185	COG1842	Phage shock protein A
E5E96_RS04190	COG0204	Acyl-transferase
E5E96_RS04210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5E96_RS04255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5E96_RS04270	COG1289	transmembrane transporter activity
E5E96_RS04275	COG1566	PFAM secretion protein HlyD family protein
E5E96_RS04290	COG1051	belongs to the nudix hydrolase family
E5E96_RS04295	COG3150	esterase
E5E96_RS04305	COG3151	Protein conserved in bacteria
E5E96_RS04310	COG0494	nUDIX hydrolase
E5E96_RS04315	COG1538	Outer membrane efflux protein
E5E96_RS04320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E5E96_RS04320	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E5E96_RS04325	COG1560	Kdo2-lipid A biosynthetic process
E5E96_RS04340	COG1392	Phosphate transport regulator
E5E96_RS04345	COG0306	phosphate transporter
E5E96_RS04350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5E96_RS04380	COG0583	DNA-binding transcription factor activity
E5E96_RS04385	COG1380	Effector of murein hydrolase LrgA
E5E96_RS04390	COG1346	cytolysis
E5E96_RS04405	COG0617	tRNA 3'-terminal CCA addition
E5E96_RS04410	COG3267	Type II secretory pathway component ExeA
E5E96_RS04410	COG3409	Peptidoglycan-binding domain 1 protein
E5E96_RS04420	COG1194	a g-specific adenine glycosylase
E5E96_RS04425	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E5E96_RS04435	COG3111	PFAM Bacterial OB fold (BOF) protein
E5E96_RS04440	COG3240	lipase activity
E5E96_RS04450	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E5E96_RS04450	COG2885	chlorophyll binding
E5E96_RS04455	COG3009	Protein conserved in bacteria
E5E96_RS04460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5E96_RS04460	COG3008	intermembrane lipid transfer
E5E96_RS04465	COG2995	paraquat-inducible protein a
E5E96_RS04475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E96_RS04485	COG2203	Gaf domain
E5E96_RS04485	COG3706	GGDEF domain
E5E96_RS04485	COG4251	negative regulation of phosphorylation
E5E96_RS04485	COG5001	Diguanylate cyclase
E5E96_RS04490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5E96_RS04495	COG2813	Specifically methylates the guanine in position
E5E96_RS04500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5E96_RS04505	COG0297	glycogen (starch) synthase activity
E5E96_RS04545	COG1757	Na H antiporter
E5E96_RS04550	COG0583	DNA-binding transcription factor activity
E5E96_RS04555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E5E96_RS04560	COG3842	ATPase activity
E5E96_RS04565	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5E96_RS04570	COG1177	transmembrane transport
E5E96_RS04575	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_RS04585	COG5006	permease, DMT superfamily
E5E96_RS04590	COG1522	sequence-specific DNA binding
E5E96_RS04595	COG0110	maltose O-acetyltransferase activity
E5E96_RS04600	COG0366	Alpha amylase catalytic
E5E96_RS04605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_RS04605	COG1263	PTS System
E5E96_RS04640	COG1803	Methylglyoxal synthase
E5E96_RS04665	COG1444	tRNA N-acetyltransferase activity
E5E96_RS04670	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_RS04675	COG0784	Response regulator, receiver
E5E96_RS04675	COG0835	chemotaxis
E5E96_RS04720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E5E96_RS04725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E5E96_RS04740	COG0477	Major facilitator Superfamily
E5E96_RS04745	COG0523	cobalamin synthesis protein
E5E96_RS04755	COG1280	lysine exporter protein (LysE YggA)
E5E96_RS04765	COG2200	EAL domain
E5E96_RS04770	COG1049	propionate catabolic process, 2-methylcitrate cycle
E5E96_RS04775	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5E96_RS04780	COG0840	transmembrane signaling receptor activity
E5E96_RS04785	COG0840	transmembrane signaling receptor activity
E5E96_RS04795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5E96_RS04800	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5E96_RS04805	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E5E96_RS04810	COG2186	Transcriptional regulator
E5E96_RS04835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5E96_RS04840	COG1459	type II secretion system
E5E96_RS04855	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E5E96_RS04860	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5E96_RS04865	COG0494	nUDIX hydrolase
E5E96_RS04875	COG0653	protein targeting
E5E96_RS04885	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E5E96_RS04890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5E96_RS04895	COG0849	cell division
E5E96_RS04900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5E96_RS04905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5E96_RS04910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5E96_RS04915	COG0772	Belongs to the SEDS family
E5E96_RS04920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5E96_RS04925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E5E96_RS04930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5E96_RS04940	COG0768	penicillin binding
E5E96_RS04945	COG3116	cell division
E5E96_RS04950	COG0275	rRNA processing
E5E96_RS04955	COG2001	Belongs to the MraZ family
E5E96_RS04965	COG1388	LysM domain
E5E96_RS04965	COG0741	lytic transglycosylase activity
E5E96_RS04970	COG1360	Flagellar Motor Protein
E5E96_RS04975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5E96_RS04980	COG1191	sigma factor activity
E5E96_RS05005	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E5E96_RS05010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5E96_RS05015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5E96_RS05030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5E96_RS05035	COG1256	bacterial-type flagellum assembly
E5E96_RS05035	COG4786	Flagellar basal body rod
E5E96_RS05045	COG1706	bacterial-type flagellum-dependent cell motility
E5E96_RS05050	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E5E96_RS05055	COG4786	Flagellar basal body rod
E5E96_RS05065	COG1749	Flagellar hook protein flgE
E5E96_RS05080	COG1815	bacterial-type flagellum-dependent cell motility
E5E96_RS05115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5E96_RS05125	COG1677	Flagellar hook-basal body complex protein FliE
E5E96_RS05150	COG1987	bacterial-type flagellum assembly
E5E96_RS05175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5E96_RS05180	COG3107	peptidoglycan biosynthetic process
E5E96_RS05185	COG0792	nuclease activity
E5E96_RS05190	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E5E96_RS05195	COG2823	Periplasmic or secreted lipoprotein
E5E96_RS05200	COG2969	positive regulation of protein catabolic process
E5E96_RS05205	COG0625	glutathione transferase activity
E5E96_RS05210	COG2857	Cytochrome c1
E5E96_RS05215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E5E96_RS05220	COG0723	plastoquinol--plastocyanin reductase activity
E5E96_RS05225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5E96_RS05230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E5E96_RS05235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5E96_RS05245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5E96_RS05250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5E96_RS05280	COG3964	amidohydrolase
E5E96_RS05295	COG3711	transcriptional antiterminator
E5E96_RS05295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_RS05300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_RS05305	COG1660	Displays ATPase and GTPase activities
E5E96_RS05310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_RS05320	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E5E96_RS05325	COG1137	ATPase activity
E5E96_RS05330	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E5E96_RS05335	COG3117	lipopolysaccharide transmembrane transporter activity
E5E96_RS05340	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5E96_RS05345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5E96_RS05345	COG0517	IMP dehydrogenase activity
E5E96_RS05350	COG1127	ABC transporter
E5E96_RS05355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5E96_RS05360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5E96_RS05365	COG2854	intermembrane phospholipid transfer
E5E96_RS05375	COG5007	Belongs to the BolA IbaG family
E5E96_RS05380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5E96_RS05385	COG0312	modulator of DNA gyrase
E5E96_RS05390	COG3028	Belongs to the UPF0307 family
E5E96_RS05400	COG2926	Belongs to the UPF0265 family
E5E96_RS05430	COG1396	sequence-specific DNA binding
E5E96_RS05435	COG3135	benzoate transporter
E5E96_RS05460	COG0840	transmembrane signaling receptor activity
E5E96_RS05470	COG3706	GGDEF domain
E5E96_RS05475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5E96_RS05480	COG2197	response regulator
E5E96_RS05485	COG0629	single-stranded DNA binding
E5E96_RS05525	COG5642	Protein of unknown function (DUF2384)
E5E96_RS05530	COG5499	transcription regulator containing HTH domain
E5E96_RS05555	COG1278	Cold shock
E5E96_RS05560	COG4771	TonB-dependent receptor
E5E96_RS05565	COG5001	Diguanylate cyclase
E5E96_RS05565	COG2203	Gaf domain
E5E96_RS05565	COG4251	negative regulation of phosphorylation
E5E96_RS05565	COG3706	GGDEF domain
E5E96_RS05575	COG0745	RESPONSE REGULATOR receiver
E5E96_RS05610	COG0346	lactoylglutathione lyase activity
E5E96_RS05625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5E96_RS05630	COG1074	ATP-dependent DNA helicase activity
E5E96_RS05635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E5E96_RS05640	COG2259	Doxx family
E5E96_RS05645	COG1741	Belongs to the pirin family
E5E96_RS05655	COG0583	DNA-binding transcription factor activity
E5E96_RS05680	COG1175	transmembrane transport
E5E96_RS05690	COG3842	ATPase activity
E5E96_RS05700	COG2199	diguanylate cyclase activity
E5E96_RS05700	COG2203	Gaf domain
E5E96_RS05720	COG1247	-acetyltransferase
E5E96_RS05725	COG0753	catalase activity
E5E96_RS05750	COG0494	nUDIX hydrolase
E5E96_RS05755	COG0628	permease
E5E96_RS05760	COG4221	oxidoreductase activity
E5E96_RS05765	COG2957	Belongs to the agmatine deiminase family
E5E96_RS05775	COG3284	Transcriptional regulator
E5E96_RS05790	COG1461	Dihydroxyacetone kinase
E5E96_RS05795	COG2376	Dihydroxyacetone kinase
E5E96_RS05800	COG2252	PERMEase
E5E96_RS05840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E5E96_RS05845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5E96_RS05850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5E96_RS05855	COG0049	tRNA binding
E5E96_RS05860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5E96_RS05865	COG2168	tRNA wobble position uridine thiolation
E5E96_RS05870	COG2923	Belongs to the DsrF TusC family
E5E96_RS05880	COG0251	oxidation-reduction process
E5E96_RS05885	COG2964	Protein conserved in bacteria
E5E96_RS05890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5E96_RS05895	COG0085	RNA polymerase activity
E5E96_RS05900	COG0222	ribosome binding
E5E96_RS05905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5E96_RS05910	COG0081	regulation of translation
E5E96_RS05915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5E96_RS05920	COG0250	Participates in transcription elongation, termination and antitermination
E5E96_RS05935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5E96_RS05960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5E96_RS05965	COG0569	domain protein
E5E96_RS05970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5E96_RS05990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5E96_RS05995	COG3005	denitrification pathway
E5E96_RS06000	COG0243	molybdopterin cofactor binding
E5E96_RS06010	COG2205	protein histidine kinase activity
E5E96_RS06030	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E5E96_RS06045	COG2204	response regulator
E5E96_RS06055	COG2205	protein histidine kinase activity
E5E96_RS06080	COG5413	integral membrane protein
E5E96_RS06090	COG1522	sequence-specific DNA binding
E5E96_RS06095	COG2502	aspartate--ammonia ligase
E5E96_RS06100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E5E96_RS06105	COG0542	response to heat
E5E96_RS06115	COG0564	pseudouridine synthase activity
E5E96_RS06120	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5E96_RS06125	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5E96_RS06135	COG3681	Belongs to the UPF0597 family
E5E96_RS06145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E5E96_RS06150	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E5E96_RS06155	COG1979	alcohol dehydrogenase
E5E96_RS06160	COG2207	Transcriptional regulator
E5E96_RS06165	COG3040	lipid binding
E5E96_RS06175	COG0688	phosphatidylethanolamine metabolic process
E5E96_RS06195	COG0540	Belongs to the ATCase OTCase family
E5E96_RS06200	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E5E96_RS06205	COG1438	arginine binding
E5E96_RS06210	COG1288	antiporter activity
E5E96_RS06215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5E96_RS06245	COG0840	transmembrane signaling receptor activity
E5E96_RS06265	COG3250	beta-galactosidase activity
E5E96_RS06270	COG1609	Transcriptional regulator
E5E96_RS06275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5E96_RS06285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E5E96_RS06290	COG2017	converts alpha-aldose to the beta-anomer
E5E96_RS06295	COG0667	Aldo Keto reductase
E5E96_RS06300	COG1968	undecaprenyl-diphosphatase activity
E5E96_RS06305	COG3806	Anti-sigma factor
E5E96_RS06310	COG1595	DNA-templated transcription, initiation
E5E96_RS06330	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E5E96_RS06335	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E5E96_RS06340	COG0477	Major facilitator Superfamily
E5E96_RS06350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5E96_RS06360	COG2116	formate transmembrane transporter activity
E5E96_RS06365	COG1648	precorrin-2 dehydrogenase activity
E5E96_RS06365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5E96_RS06370	COG2239	Acts as a magnesium transporter
E5E96_RS06380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5E96_RS06385	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E5E96_RS06395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5E96_RS06405	COG0514	ATP-dependent DNA helicase (RecQ)
E5E96_RS06410	COG2050	protein possibly involved in aromatic compounds catabolism
E5E96_RS06425	COG2258	MOSC domain
E5E96_RS06430	COG1177	transmembrane transport
E5E96_RS06435	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5E96_RS06440	COG3842	ATPase activity
E5E96_RS06460	COG0174	glutamine synthetase
E5E96_RS06480	COG3045	CreA protein
E5E96_RS06485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5E96_RS06490	COG0443	Heat shock 70 kDa protein
E5E96_RS06505	COG0366	Alpha amylase catalytic
E5E96_RS06510	COG1086	Polysaccharide biosynthesis protein
E5E96_RS06515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5E96_RS06520	COG4750	Nucleotidyl transferase
E5E96_RS06525	COG0512	Glutamine amidotransferase of anthranilate synthase
E5E96_RS06525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5E96_RS06540	COG0529	Catalyzes the synthesis of activated sulfate
E5E96_RS06560	COG0438	transferase activity, transferring glycosyl groups
E5E96_RS06575	COG1215	transferase activity, transferring glycosyl groups
E5E96_RS06590	COG0318	PFAM AMP-dependent synthetase and ligase
E5E96_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_RS06610	COG1083	cytidylyl-transferase
E5E96_RS06620	COG2089	acid synthase
E5E96_RS06640	COG4310	Domain of unknown function (DUF2172)
E5E96_RS06675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5E96_RS06680	COG0745	RESPONSE REGULATOR receiver
E5E96_RS06685	COG2205	protein histidine kinase activity
E5E96_RS06695	COG0281	malic enzyme
E5E96_RS06700	COG0702	epimerase
E5E96_RS06705	COG0254	rRNA binding
E5E96_RS06710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5E96_RS06730	COG0129	dihydroxy-acid dehydratase activity
E5E96_RS06740	COG3978	acetolactate synthase activity
E5E96_RS06750	COG0606	chelatase, subunit chli
E5E96_RS06755	COG0204	Acyl-transferase
E5E96_RS06760	COG0204	Acyl-transferase
E5E96_RS06765	COG1683	Conserved Protein
E5E96_RS06775	COG1335	isochorismatase
E5E96_RS06785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5E96_RS06790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5E96_RS06800	COG3084	Protein conserved in bacteria
E5E96_RS06805	COG4251	negative regulation of phosphorylation
E5E96_RS06805	COG5001	Diguanylate cyclase
E5E96_RS06805	COG2203	Gaf domain
E5E96_RS06805	COG3706	GGDEF domain
E5E96_RS06810	COG0789	Transcriptional regulator
E5E96_RS06820	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5E96_RS06825	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5E96_RS06830	COG1561	YicC-like family, N-terminal region
E5E96_RS06850	COG3306	glycosyltransferase involved in LPS biosynthesis
E5E96_RS06865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5E96_RS06875	COG0156	8-amino-7-oxononanoate synthase activity
E5E96_RS06880	COG1063	alcohol dehydrogenase
E5E96_RS06885	COG3245	cytochrome
E5E96_RS06895	COG0210	DNA helicase
E5E96_RS06900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5E96_RS06905	COG2166	iron-sulfur cluster assembly
E5E96_RS06910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5E96_RS06950	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5E96_RS06960	COG0583	DNA-binding transcription factor activity
E5E96_RS06975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5E96_RS06980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5E96_RS06985	COG2223	nitrite transmembrane transporter activity
E5E96_RS06990	COG3279	Response regulator of the LytR AlgR family
E5E96_RS06995	COG3275	phosphorelay sensor kinase activity
E5E96_RS07005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_RS07005	COG2205	protein histidine kinase activity
E5E96_RS07025	COG3188	usher protein
E5E96_RS07045	COG2223	nitrite transmembrane transporter activity
E5E96_RS07050	COG2081	HI0933 family
E5E96_RS07055	COG1528	Iron-storage protein
E5E96_RS07060	COG3706	GGDEF domain
E5E96_RS07065	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5E96_RS07070	COG0589	response to stress
E5E96_RS07110	COG3642	lipopolysaccharide core region biosynthetic process
E5E96_RS07115	COG0859	PFAM glycosyl transferase family 9
E5E96_RS07125	COG1758	RNA polymerase activity
E5E96_RS07130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5E96_RS07135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5E96_RS07140	COG2267	carboxylic ester hydrolase activity
E5E96_RS07145	COG0561	phosphatase activity
E5E96_RS07175	COG1309	transcriptional regulator
E5E96_RS07180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_RS07185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E96_RS07190	COG4191	Histidine kinase
E5E96_RS07190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_RS07195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5E96_RS07230	COG2205	protein histidine kinase activity
E5E96_RS07235	COG0745	RESPONSE REGULATOR receiver
E5E96_RS07240	COG2814	Major facilitator Superfamily
E5E96_RS07255	COG3977	Valine--pyruvate aminotransferase
E5E96_RS07260	COG0071	Belongs to the small heat shock protein (HSP20) family
E5E96_RS07265	COG0071	Belongs to the small heat shock protein (HSP20) family
E5E96_RS07270	COG2378	regulation of single-species biofilm formation
E5E96_RS07285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5E96_RS07290	COG0592	DNA-directed DNA polymerase activity
E5E96_RS07295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5E96_RS07320	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5E96_RS07325	COG0594	ribonuclease P activity
E5E96_RS07330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5E96_RS07335	COG0706	membrane insertase activity
E5E96_RS07340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5E96_RS07360	COG4615	Cyclic peptide transporter
E5E96_RS07365	COG4774	siderophore transport
E5E96_RS07370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5E96_RS07375	COG0445	tRNA wobble uridine modification
E5E96_RS07380	COG0357	Ribosomal RNA small subunit methyltransferase G
E5E96_RS07385	COG1192	Involved in chromosome partitioning
E5E96_RS07390	COG1475	DNA binding
E5E96_RS07400	COG0356	it plays a direct role in the translocation of protons across the membrane
E5E96_RS07410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E5E96_RS07415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5E96_RS07420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5E96_RS07425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5E96_RS07430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5E96_RS07435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5E96_RS07440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5E96_RS07445	COG4452	Inner membrane protein CreD
E5E96_RS07460	COG0745	RESPONSE REGULATOR receiver
E5E96_RS07465	COG1349	DNA-binding transcription factor activity
E5E96_RS07475	COG2771	luxR family
E5E96_RS07485	COG0811	peptide transport
E5E96_RS07490	COG0811	peptide transport
E5E96_RS07495	COG0848	biopolymer transport protein
E5E96_RS07500	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E5E96_RS07540	COG0402	S-adenosylhomocysteine deaminase activity
E5E96_RS07545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5E96_RS07555	COG3165	ubiquinone biosynthetic process from chorismate
E5E96_RS07560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5E96_RS07570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5E96_RS07575	COG0805	protein transport
E5E96_RS07580	COG0084	hydrolase, TatD family'
E5E96_RS07600	COG0742	ribosomal rna small subunit methyltransferase
E5E96_RS07615	COG0248	Ppx GppA phosphatase
E5E96_RS07620	COG0513	Belongs to the DEAD box helicase family
E5E96_RS07625	COG3118	belongs to the thioredoxin family
E5E96_RS07640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E5E96_RS07665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5E96_RS07705	COG1609	Transcriptional regulator
E5E96_RS07710	COG3604	Transcriptional regulator
E5E96_RS07715	COG1773	rubredoxin
E5E96_RS07715	COG0426	domain, Protein
E5E96_RS07720	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5E96_RS07730	COG0348	domain, Protein
E5E96_RS07735	COG0814	amino acid
E5E96_RS07770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5E96_RS07780	COG0751	glycine-tRNA ligase activity
E5E96_RS07785	COG0752	glycyl-tRNA synthetase alpha subunit
E5E96_RS07790	COG2818	Glycosylase
E5E96_RS07800	COG2885	chlorophyll binding
E5E96_RS07805	COG0251	oxidation-reduction process
E5E96_RS07810	COG0425	Belongs to the sulfur carrier protein TusA family
E5E96_RS07825	COG2205	protein histidine kinase activity
E5E96_RS07830	COG0745	RESPONSE REGULATOR receiver
E5E96_RS07835	COG0183	Belongs to the thiolase family
E5E96_RS07840	COG1024	Enoyl-CoA hydratase
E5E96_RS07840	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5E96_RS07845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5E96_RS07850	COG0006	proline dipeptidase activity
E5E96_RS07855	COG1739	Uncharacterized protein family UPF0029
E5E96_RS07860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5E96_RS07865	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E5E96_RS07890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5E96_RS07890	COG1042	CoA-binding domain protein
E5E96_RS07890	COG0045	succinate-CoA ligase (ADP-forming) activity
E5E96_RS07905	COG0583	DNA-binding transcription factor activity
E5E96_RS07910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5E96_RS07915	COG0166	Belongs to the GPI family
E5E96_RS07925	COG0668	transmembrane transport
E5E96_RS07930	COG1309	transcriptional regulator
E5E96_RS07935	COG0756	dUTP diphosphatase activity
E5E96_RS07940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5E96_RS07945	COG2003	Belongs to the UPF0758 family
E5E96_RS07950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5E96_RS07955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5E96_RS07965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E5E96_RS07970	COG2990	Protein conserved in bacteria
E5E96_RS07975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5E96_RS07980	COG0859	PFAM glycosyl transferase family 9
E5E96_RS07985	COG0463	Glycosyl transferase, family 2
E5E96_RS07990	COG0859	PFAM glycosyl transferase family 9
E5E96_RS07995	COG1519	Transferase
E5E96_RS08015	COG1609	Transcriptional regulator
E5E96_RS08020	COG0604	alcohol dehydrogenase
E5E96_RS08035	COG1580	Controls the rotational direction of flagella during chemotaxis
E5E96_RS08040	COG3161	chorismate lyase activity
E5E96_RS08045	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5E96_RS08050	COG2937	Belongs to the GPAT DAPAT family
E5E96_RS08055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5E96_RS08070	COG0534	Mate efflux family protein
E5E96_RS08075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5E96_RS08080	COG2205	protein histidine kinase activity
E5E96_RS08085	COG0745	RESPONSE REGULATOR receiver
E5E96_RS08095	COG1045	serine acetyltransferase
E5E96_RS08105	COG3074	FtsZ-dependent cytokinesis
E5E96_RS08110	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E5E96_RS08115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5E96_RS08115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5E96_RS08120	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E5E96_RS08155	COG1609	Transcriptional regulator
E5E96_RS08160	COG3250	beta-galactosidase activity
E5E96_RS08165	COG2731	YhcH YjgK YiaL family protein
E5E96_RS08170	COG0531	amino acid
E5E96_RS08175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E96_RS08180	COG0531	amino acid
E5E96_RS08185	COG0385	Bile acid
E5E96_RS08190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5E96_RS08210	COG0583	DNA-binding transcription factor activity
E5E96_RS08235	COG0210	DNA helicase
E5E96_RS08250	COG1943	Transposase
E5E96_RS08305	COG1280	lysine exporter protein (LysE YggA)
E5E96_RS08310	COG2391	methyltransferase activity
E5E96_RS08315	COG0840	transmembrane signaling receptor activity
E5E96_RS08325	COG1280	lysine exporter protein (LysE YggA)
E5E96_RS08335	COG2962	Rard protein
E5E96_RS08345	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_RS08350	COG1396	sequence-specific DNA binding
E5E96_RS08365	COG0519	Catalyzes the synthesis of GMP from XMP
E5E96_RS08365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5E96_RS08370	COG0686	Belongs to the AlaDH PNT family
E5E96_RS08375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E96_RS08395	COG1322	Protein conserved in bacteria
E5E96_RS08400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5E96_RS08405	COG0569	domain protein
E5E96_RS08410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5E96_RS08410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5E96_RS08415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5E96_RS08420	COG0242	peptide deformylase activity
E5E96_RS08430	COG0758	DNA mediated transformation
E5E96_RS08435	COG2922	Belongs to the Smg family
E5E96_RS08440	COG0551	DNA topoisomerase type I activity
E5E96_RS08450	COG0009	L-threonylcarbamoyladenylate synthase
E5E96_RS08455	COG0408	coproporphyrinogen oxidase activity
E5E96_RS08460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E5E96_RS08470	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5E96_RS08480	COG3078	GTPase activator activity
E5E96_RS08490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5E96_RS08495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5E96_RS08500	COG2204	response regulator
E5E96_RS08505	COG3852	Histidine kinase
E5E96_RS08515	COG0174	glutamine synthetase
E5E96_RS08525	COG1295	ribonuclease BN
E5E96_RS08530	COG1490	D-aminoacyl-tRNA deacylase activity
E5E96_RS08540	COG0456	acetyltransferase
E5E96_RS08550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5E96_RS08555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5E96_RS08560	COG2610	gluconate transmembrane transporter activity
E5E96_RS08565	COG3265	gluconokinase activity
E5E96_RS08575	COG0800	Aldolase
E5E96_RS08580	COG1609	Transcriptional regulator
E5E96_RS08590	COG4942	peptidase
E5E96_RS08595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5E96_RS08600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5E96_RS08605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E5E96_RS08610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5E96_RS08615	COG0316	Belongs to the HesB IscA family
E5E96_RS08615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E5E96_RS08625	COG0596	Alpha beta hydrolase
E5E96_RS08645	COG2183	response to ionizing radiation
E5E96_RS08650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5E96_RS08655	COG0745	RESPONSE REGULATOR receiver
E5E96_RS08670	COG0051	transcription antitermination factor activity, RNA binding
E5E96_RS08675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5E96_RS08680	COG0088	Forms part of the polypeptide exit tunnel
E5E96_RS08685	COG0089	rRNA binding
E5E96_RS08690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5E96_RS08695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E5E96_RS08700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5E96_RS08705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E5E96_RS08710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5E96_RS08715	COG0255	Belongs to the universal ribosomal protein uL29 family
E5E96_RS08720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5E96_RS08725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E5E96_RS08730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E5E96_RS08735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E5E96_RS08740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5E96_RS08745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5E96_RS08750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5E96_RS08755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5E96_RS08760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5E96_RS08765	COG1841	ribosomal large subunit assembly
E5E96_RS08770	COG0200	Binds to the 23S rRNA
E5E96_RS08775	COG0201	protein transport
E5E96_RS08780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5E96_RS08785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5E96_RS08790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5E96_RS08795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5E96_RS08800	COG0202	RNA polymerase activity
E5E96_RS08805	COG0203	ribosomal protein L17
E5E96_RS08860	COG2249	NAD(P)H dehydrogenase (quinone) activity
E5E96_RS08865	COG0583	DNA-binding transcription factor activity
E5E96_RS08870	COG4221	oxidoreductase activity
E5E96_RS08885	COG1770	oligopeptidase
E5E96_RS08905	COG3714	YhhN family
E5E96_RS08930	COG1301	dicarboxylic acid transport
E5E96_RS08940	COG2095	MarC family integral membrane protein
E5E96_RS08950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E5E96_RS08960	COG0741	lytic transglycosylase activity
E5E96_RS08970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5E96_RS08995	COG0742	ribosomal rna small subunit methyltransferase
E5E96_RS09000	COG0552	protein localization to endoplasmic reticulum
E5E96_RS09005	COG2884	Cell division ATP-binding protein ftsE
E5E96_RS09010	COG2177	Part of the ABC transporter FtsEX involved in
E5E96_RS09020	COG0288	reversible hydration of carbon dioxide
E5E96_RS09025	COG2188	Transcriptional regulator
E5E96_RS09030	COG1228	amidohydrolase
E5E96_RS09035	COG0010	Belongs to the arginase family
E5E96_RS09040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5E96_RS09045	COG2986	histidine ammonia-lyase
E5E96_RS09050	COG0387	Pfam Sodium calcium exchanger
E5E96_RS09055	COG2200	EAL domain
E5E96_RS09060	COG2200	EAL domain
E5E96_RS09060	COG2199	diguanylate cyclase activity
E5E96_RS09105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5E96_RS09110	COG1459	type II secretion system
E5E96_RS09155	COG1077	Cell shape determining protein MreB Mrl
E5E96_RS09160	COG1792	Involved in formation and maintenance of cell shape
E5E96_RS09165	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E5E96_RS09170	COG0424	maF-like protein
E5E96_RS09180	COG3164	Protein of unknown function
E5E96_RS09190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5E96_RS09195	COG0312	modulator of DNA gyrase
E5E96_RS09220	COG1263	PTS System
E5E96_RS09220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_RS09225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E5E96_RS09240	COG0477	Major facilitator Superfamily
E5E96_RS09250	COG3437	response regulator, receiver
E5E96_RS09255	COG0784	Response regulator, receiver
E5E96_RS09255	COG2205	protein histidine kinase activity
E5E96_RS09255	COG5002	protein histidine kinase activity
E5E96_RS09260	COG2172	sigma factor antagonist activity
E5E96_RS09265	COG1366	Belongs to the anti-sigma-factor antagonist family
E5E96_RS09285	COG3700	Belongs to the class B bacterial acid phosphatase family
E5E96_RS09290	COG2321	neutral zinc metallopeptidase
E5E96_RS09300	COG1639	'signal transduction protein
E5E96_RS09320	COG1410	methionine synthase
E5E96_RS09320	COG0646	methionine synthase
E5E96_RS09325	COG0189	ligase activity
E5E96_RS09335	COG0642	Histidine kinase
E5E96_RS09340	COG0745	RESPONSE REGULATOR receiver
E5E96_RS09360	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E5E96_RS09365	COG0352	thiamine-phosphate diphosphorylase activity
E5E96_RS09370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5E96_RS09380	COG2022	thiamine diphosphate biosynthetic process
E5E96_RS09385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5E96_RS09405	COG0110	maltose O-acetyltransferase activity
E5E96_RS09410	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E5E96_RS09430	COG3706	GGDEF domain
E5E96_RS09435	COG0814	amino acid
E5E96_RS09440	COG3932	Exopolysaccharide synthesis, ExoD
E5E96_RS09460	COG1733	regulation of RNA biosynthetic process
E5E96_RS09500	COG1494	fructose-1,6-bisphosphatase
E5E96_RS09515	COG2959	enzyme of heme biosynthesis
E5E96_RS09525	COG0181	hydroxymethylbilane synthase activity
E5E96_RS09530	COG3072	Adenylate cyclase
E5E96_RS09535	COG0400	carboxylic ester hydrolase activity
E5E96_RS09540	COG1965	Belongs to the frataxin family
E5E96_RS09550	COG0019	diaminopimelate decarboxylase activity
E5E96_RS09555	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5E96_RS09570	COG1011	Hydrolase
E5E96_RS09590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E5E96_RS09595	COG0561	phosphatase activity
E5E96_RS09610	COG0842	Transport permease protein
E5E96_RS09610	COG1129	ABC transporter
E5E96_RS09620	COG1546	Belongs to the CinA family
E5E96_RS09620	COG1058	Belongs to the CinA family
E5E96_RS09625	COG1418	mRNA catabolic process
E5E96_RS09630	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E5E96_RS09640	COG1522	sequence-specific DNA binding
E5E96_RS09645	COG1368	sulfuric ester hydrolase activity
E5E96_RS09665	COG1285	pathogenesis
E5E96_RS09685	COG4221	oxidoreductase activity
E5E96_RS09715	COG2873	o-acetylhomoserine
E5E96_RS09725	COG4533	DNA binding
E5E96_RS09740	COG5380	lipid catabolic process
E5E96_RS09745	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E5E96_RS09755	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5E96_RS09760	COG2949	membrane
E5E96_RS09765	COG3291	Pkd domain containing protein
E5E96_RS09775	COG3539	Fimbrial protein
E5E96_RS09785	COG3188	usher protein
E5E96_RS09790	COG3121	Chaperone
E5E96_RS09795	COG3539	Fimbrial protein
E5E96_RS09810	COG0318	PFAM AMP-dependent synthetase and ligase
E5E96_RS09820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5E96_RS09825	COG0596	Alpha beta hydrolase
E5E96_RS09835	COG1169	isochorismate synthase
E5E96_RS09840	COG1575	Belongs to the MenA family. Type 1 subfamily
E5E96_RS09865	COG0513	Belongs to the DEAD box helicase family
E5E96_RS09870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E96_RS09875	COG1988	membrane-bound metal-dependent
E5E96_RS09890	COG1671	Belongs to the UPF0178 family
E5E96_RS09915	COG3263	regulation of cellular component size
E5E96_RS09920	COG3722	fumarate hydratase activity
E5E96_RS09925	COG0246	Mannitol dehydrogenase
E5E96_RS09930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_RS09930	COG2213	PTS system mannitol-specific
E5E96_RS09940	COG1309	transcriptional regulator
E5E96_RS09945	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E5E96_RS09955	COG3916	Acyl-homoserine-lactone synthase
E5E96_RS09960	COG2771	luxR family
E5E96_RS09975	COG3133	Outer membrane lipoprotein
E5E96_RS10005	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5E96_RS10015	COG3031	protein transport across the cell outer membrane
E5E96_RS10025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5E96_RS10030	COG1459	type II secretion system
E5E96_RS10035	COG2165	general secretion pathway protein
E5E96_RS10050	COG2165	general secretion pathway protein
E5E96_RS10055	COG4795	General secretion pathway protein
E5E96_RS10065	COG3156	type II secretion system protein K
E5E96_RS10075	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E5E96_RS10090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5E96_RS10095	COG1011	Hydrolase
E5E96_RS10100	COG0494	nUDIX hydrolase
E5E96_RS10105	COG1218	3'(2'),5'-bisphosphate nucleotidase
E5E96_RS10110	COG0814	amino acid
E5E96_RS10115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E96_RS10120	COG3708	Transcriptional regulator
E5E96_RS10120	COG2207	Transcriptional regulator
E5E96_RS10130	COG0626	cystathionine gamma-synthase activity
E5E96_RS10135	COG0460	homoserine dehydrogenase
E5E96_RS10135	COG0527	aspartate kinase activity
E5E96_RS10145	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E5E96_RS10155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5E96_RS10160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5E96_RS10170	COG0137	argininosuccinate synthase activity
E5E96_RS10175	COG0165	Argininosuccinate lyase
E5E96_RS10195	COG0110	maltose O-acetyltransferase activity
E5E96_RS10200	COG3174	membrane
E5E96_RS10205	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5E96_RS10215	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E5E96_RS10220	COG4208	sulfate ABC transporter
E5E96_RS10225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E5E96_RS10230	COG0583	DNA-binding transcription factor activity
E5E96_RS10235	COG3397	chitin binding
E5E96_RS10240	COG0840	transmembrane signaling receptor activity
E5E96_RS10270	COG0793	Belongs to the peptidase S41A family
E5E96_RS10270	COG4946	Tricorn protease homolog
E5E96_RS10290	COG1328	CTP reductase activity
E5E96_RS10295	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E96_RS10310	COG1448	Aminotransferase
E5E96_RS10350	COG0513	Belongs to the DEAD box helicase family
E5E96_RS10370	COG0840	transmembrane signaling receptor activity
E5E96_RS10385	COG3112	Uncharacterised protein family (UPF0231)
E5E96_RS10390	COG3835	regulator
E5E96_RS10395	COG2610	gluconate transmembrane transporter activity
E5E96_RS10400	COG1929	Belongs to the glycerate kinase type-1 family
E5E96_RS10415	COG0583	DNA-binding transcription factor activity
E5E96_RS10420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E96_RS10435	COG0347	Belongs to the P(II) protein family
E5E96_RS10440	COG1840	ABC-type Fe3 transport system, periplasmic component
E5E96_RS10450	COG3842	ATPase activity
E5E96_RS10460	COG1438	arginine binding
E5E96_RS10470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_RS10475	COG4215	(ABC) transporter
E5E96_RS10480	COG4160	amino acid transport
E5E96_RS10485	COG0039	L-malate dehydrogenase activity
E5E96_RS10490	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E5E96_RS10495	COG1017	nitric oxide dioxygenase activity
E5E96_RS10495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5E96_RS10505	COG4536	flavin adenine dinucleotide binding
E5E96_RS10510	COG4137	Cytochrome C assembly protein
E5E96_RS10515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5E96_RS10520	COG0228	four-way junction DNA binding
E5E96_RS10525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5E96_RS10530	COG0336	Belongs to the RNA methyltransferase TrmD family
E5E96_RS10535	COG0335	large ribosomal subunit rRNA binding
E5E96_RS10545	COG3066	DNA modification
E5E96_RS10550	COG1051	belongs to the nudix hydrolase family
E5E96_RS10560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E5E96_RS10565	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5E96_RS10570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5E96_RS10580	COG0583	DNA-binding transcription factor activity
E5E96_RS10585	COG0640	Transcriptional regulator
E5E96_RS10590	COG0268	Binds directly to 16S ribosomal RNA
E5E96_RS10595	COG0728	peptidoglycan biosynthetic process
E5E96_RS10605	COG0196	riboflavin kinase activity
E5E96_RS10610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5E96_RS10615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5E96_RS10620	COG1047	Peptidyl-prolyl cis-trans
E5E96_RS10625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5E96_RS10685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5E96_RS10685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5E96_RS10700	COG1854	S-ribosylhomocysteine lyase activity
E5E96_RS10705	COG3706	GGDEF domain
E5E96_RS10710	COG0557	exoribonuclease II activity
E5E96_RS10715	COG1204	response to ionizing radiation
E5E96_RS10725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5E96_RS10735	COG2153	protein acetylation
E5E96_RS10750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5E96_RS10755	COG1914	H( )-stimulated, divalent metal cation uptake system
E5E96_RS10760	COG0360	Binds together with S18 to 16S ribosomal RNA
E5E96_RS10765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5E96_RS10770	COG0359	binds to the 23S rRNA
E5E96_RS10775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5E96_RS10800	COG1238	metal cluster binding
E5E96_RS10805	COG0612	Peptidase, M16
E5E96_RS10810	COG2918	glutathione biosynthetic process
E5E96_RS10820	COG1022	Amp-dependent synthetase and ligase
E5E96_RS10830	COG0456	acetyltransferase
E5E96_RS10840	COG0714	Associated with various cellular activities
E5E96_RS10850	COG5001	Diguanylate cyclase
E5E96_RS10850	COG3300	MHYT domain
E5E96_RS10885	COG1902	pentaerythritol trinitrate reductase activity
E5E96_RS10890	COG1309	transcriptional regulator
E5E96_RS10900	COG2957	Belongs to the agmatine deiminase family
E5E96_RS10940	COG0513	Belongs to the DEAD box helicase family
E5E96_RS10980	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E5E96_RS10985	COG1858	cytochrome C peroxidase
E5E96_RS11010	COG2070	2-Nitropropane dioxygenase
E5E96_RS11040	COG2816	NAD+ diphosphatase activity
E5E96_RS11045	COG2205	protein histidine kinase activity
E5E96_RS11050	COG0745	RESPONSE REGULATOR receiver
E5E96_RS11055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5E96_RS11060	COG0577	efflux transmembrane transporter activity
E5E96_RS11060	COG1136	(ABC) transporter
E5E96_RS11065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_RS11070	COG1126	abc transporter atp-binding protein
E5E96_RS11075	COG0765	amino acid transport
E5E96_RS11080	COG0765	amino acid transport
E5E96_RS11085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5E96_RS11090	COG1505	serine-type exopeptidase activity
E5E96_RS11105	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_RS11110	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5E96_RS11125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5E96_RS11130	COG4991	sh3 domain protein
E5E96_RS11140	COG2816	NAD+ diphosphatase activity
E5E96_RS11145	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5E96_RS11150	COG1940	carbohydrate kinase activity
E5E96_RS11155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5E96_RS11160	COG0126	phosphoglycerate kinase activity
E5E96_RS11170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E96_RS11180	COG4232	protein-disulfide reductase activity
E5E96_RS11210	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E5E96_RS11220	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E5E96_RS11225	COG1595	DNA-templated transcription, initiation
E5E96_RS11230	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E5E96_RS11245	COG0481	GTPase activity
E5E96_RS11250	COG0681	Belongs to the peptidase S26 family
E5E96_RS11255	COG0571	ribonuclease III activity
E5E96_RS11265	COG1381	Involved in DNA repair and RecF pathway recombination
E5E96_RS11270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5E96_RS11285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5E96_RS11290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_RS11295	COG3716	PTS system mannose fructose sorbose family IID component
E5E96_RS11305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_RS11310	COG2222	sugar isomerase
E5E96_RS11320	COG1349	DNA-binding transcription factor activity
E5E96_RS11325	COG3023	N-Acetylmuramoyl-L-alanine amidase
E5E96_RS11330	COG4807	Protein conserved in bacteria
E5E96_RS11340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5E96_RS11345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5E96_RS11350	COG3956	TIGRFAM MazG family protein
E5E96_RS11355	COG0504	CTP synthase activity
E5E96_RS11360	COG0148	phosphopyruvate hydratase activity
E5E96_RS11365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E5E96_RS11370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5E96_RS11380	COG0585	pseudouridine synthase activity
E5E96_RS11385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5E96_RS11390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5E96_RS11395	COG1238	metal cluster binding
E5E96_RS11410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E5E96_RS11415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5E96_RS11420	COG1610	YqeY-like protein
E5E96_RS11425	COG0358	DNA primase activity
E5E96_RS11430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5E96_RS11455	COG0151	Belongs to the GarS family
E5E96_RS11460	COG0138	bifunctional purine biosynthesis protein purh
E5E96_RS11470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E5E96_RS11475	COG3036	rescue of stalled ribosome
E5E96_RS11480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5E96_RS11485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5E96_RS11495	COG0673	inositol 2-dehydrogenase activity
E5E96_RS11505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5E96_RS11510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5E96_RS11525	COG0477	Major facilitator Superfamily
E5E96_RS11535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E5E96_RS11540	COG1027	Aspartate ammonia-lyase
E5E96_RS11545	COG3030	protein affecting phage T7 exclusion by the F plasmid
E5E96_RS11550	COG0534	Mate efflux family protein
E5E96_RS11555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5E96_RS11560	COG0459	protein refolding
E5E96_RS11570	COG5001	Diguanylate cyclase
E5E96_RS11570	COG3300	MHYT domain
E5E96_RS11580	COG0564	pseudouridine synthase activity
E5E96_RS11585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E5E96_RS11625	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E5E96_RS11630	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E5E96_RS11635	COG1178	ABC-type Fe3 transport system permease component
E5E96_RS11640	COG4143	(ABC) transporter
E5E96_RS11655	COG0066	3-isopropylmalate dehydratase activity
E5E96_RS11660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5E96_RS11665	COG0473	3-isopropylmalate dehydrogenase activity
E5E96_RS11670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5E96_RS11680	COG0671	phosphoesterase, PA-phosphatase related
E5E96_RS11695	COG0028	Belongs to the TPP enzyme family
E5E96_RS11705	COG0857	belongs to the CobB CobQ family
E5E96_RS11705	COG0280	phosphate acetyltransferase
E5E96_RS11710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5E96_RS11720	COG3013	Belongs to the UPF0304 family
E5E96_RS11725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5E96_RS11730	COG2716	regulation of RNA biosynthetic process
E5E96_RS11740	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E5E96_RS11745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5E96_RS11760	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
E5E96_RS11780	COG0784	Response regulator, receiver
E5E96_RS11780	COG5002	protein histidine kinase activity
E5E96_RS11780	COG2198	Histidine kinase
E5E96_RS11805	COG0840	transmembrane signaling receptor activity
E5E96_RS11820	COG1464	Belongs to the NlpA lipoprotein family
E5E96_RS11825	COG2011	ABC-type metal ion transport system permease component
E5E96_RS11830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5E96_RS11845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5E96_RS11850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5E96_RS11850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5E96_RS11855	COG0802	atpase or kinase
E5E96_RS11865	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5E96_RS11870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5E96_RS11875	COG1923	regulation of RNA biosynthetic process
E5E96_RS11880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5E96_RS11885	COG0330	HflC and HflK could
E5E96_RS11890	COG0330	HflC and HflK could
E5E96_RS11895	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E5E96_RS11900	COG0142	geranyltranstransferase activity
E5E96_RS11905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5E96_RS11910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5E96_RS11915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5E96_RS11925	COG0318	PFAM AMP-dependent synthetase and ligase
E5E96_RS11940	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E96_RS11945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5E96_RS11955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5E96_RS11960	COG2967	ApaG domain
E5E96_RS11965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5E96_RS11970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E5E96_RS11980	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E5E96_RS11985	COG3178	'Phosphotransferase
E5E96_RS11990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5E96_RS11995	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E5E96_RS12000	COG2252	PERMEase
E5E96_RS12010	COG0488	(ABC) transporter
E5E96_RS12025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5E96_RS12030	COG0741	lytic transglycosylase activity
E5E96_RS12050	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E5E96_RS12055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E5E96_RS12060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E5E96_RS12085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5E96_RS12095	COG3721	Heme iron utilization protein
E5E96_RS12100	COG0748	coenzyme F420 binding
E5E96_RS12120	COG4771	TonB-dependent receptor
E5E96_RS12125	COG2814	Major facilitator Superfamily
E5E96_RS12130	COG3655	Transcriptional regulator
E5E96_RS12140	COG2202	Pas domain
E5E96_RS12140	COG2205	protein histidine kinase activity
E5E96_RS12155	COG3397	chitin binding
E5E96_RS12160	COG2226	methyltransferase
E5E96_RS12170	COG1765	OsmC-like protein
E5E96_RS12185	COG3954	Phosphoribulokinase
E5E96_RS12190	COG2076	Multidrug Resistance protein
E5E96_RS12195	COG2076	Multidrug Resistance protein
E5E96_RS12200	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E5E96_RS12205	COG0726	polysaccharide deacetylase
E5E96_RS12210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E5E96_RS12210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5E96_RS12215	COG0463	Glycosyl transferase, family 2
E5E96_RS12220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5E96_RS12230	COG3089	Belongs to the UPF0270 family
E5E96_RS12235	COG3706	GGDEF domain
E5E96_RS12235	COG4251	negative regulation of phosphorylation
E5E96_RS12235	COG5001	Diguanylate cyclase
E5E96_RS12235	COG2203	Gaf domain
E5E96_RS12240	COG0429	hydrolase of the alpha beta-hydrolase fold
E5E96_RS12245	COG0784	Response regulator, receiver
E5E96_RS12245	COG0835	chemotaxis
E5E96_RS12255	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E5E96_RS12260	COG1047	Peptidyl-prolyl cis-trans
E5E96_RS12275	COG0545	Peptidyl-prolyl cis-trans isomerase
E5E96_RS12280	COG2204	response regulator
E5E96_RS12300	COG0737	Belongs to the 5'-nucleotidase family
E5E96_RS12305	COG2200	EAL domain
E5E96_RS12315	COG0305	Participates in initiation and elongation during chromosome replication
E5E96_RS12320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5E96_RS12330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_RS12340	COG2203	Gaf domain
E5E96_RS12340	COG2200	EAL domain
E5E96_RS12340	COG2199	diguanylate cyclase activity
E5E96_RS12365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5E96_RS12370	COG2201	protein-glutamate methylesterase activity
E5E96_RS12375	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E5E96_RS12385	COG0840	transmembrane signaling receptor activity
E5E96_RS12390	COG0835	chemotaxis
E5E96_RS12400	COG0643	Histidine kinase
E5E96_RS12400	COG2198	Histidine kinase
E5E96_RS12415	COG0840	transmembrane signaling receptor activity
E5E96_RS12430	COG1280	lysine exporter protein (LysE YggA)
E5E96_RS12435	COG0826	peptidase U32
E5E96_RS12465	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E5E96_RS12490	COG0300	oxidoreductase activity
E5E96_RS12500	COG0840	transmembrane signaling receptor activity
E5E96_RS12510	COG0235	Class ii aldolase
E5E96_RS12515	COG1454	alcohol dehydrogenase
E5E96_RS12520	COG4977	sequence-specific DNA binding
E5E96_RS12530	COG4806	L-rhamnose isomerase
E5E96_RS12540	COG3254	rhamnose metabolic process
E5E96_RS12590	COG2003	Belongs to the UPF0758 family
E5E96_RS12625	COG5377	YqaJ viral recombinase family
E5E96_RS12655	COG1605	Chorismate mutase
E5E96_RS12655	COG0077	Prephenate dehydratase
E5E96_RS12685	COG3272	Protein of unknown function (DUF1722)
E5E96_RS12690	COG0789	Transcriptional regulator
E5E96_RS12695	COG0415	Belongs to the DNA photolyase family
E5E96_RS12705	COG4221	oxidoreductase activity
E5E96_RS12720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5E96_RS12745	COG0783	Belongs to the Dps family
E5E96_RS12750	COG1151	hydroxylamine reductase activity
E5E96_RS12760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5E96_RS12765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5E96_RS12765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5E96_RS12895	COG3311	Transcriptional regulator
E5E96_RS12915	COG3501	Rhs element vgr protein
E5E96_RS12945	COG2771	luxR family
E5E96_RS13000	COG0693	protein deglycase activity
E5E96_RS13005	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E5E96_RS13010	COG1666	GTP binding
E5E96_RS13020	COG2211	Major facilitator Superfamily
E5E96_RS13030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5E96_RS13040	COG2813	Specifically methylates the guanine in position
E5E96_RS13045	COG0271	Belongs to the BolA IbaG family
E5E96_RS13050	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E96_RS13055	COG1805	sodium ion transport
E5E96_RS13060	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E96_RS13065	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E96_RS13070	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E5E96_RS13075	COG2871	sodium ion transport
E5E96_RS13080	COG1477	protein flavinylation
E5E96_RS13095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5E96_RS13100	COG0840	transmembrane signaling receptor activity
E5E96_RS13105	COG0583	DNA-binding transcription factor activity
E5E96_RS13115	COG2363	Small membrane protein
E5E96_RS13120	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E5E96_RS13130	COG0473	3-isopropylmalate dehydrogenase activity
E5E96_RS13135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5E96_RS13140	COG1611	Belongs to the LOG family
E5E96_RS13145	COG3706	GGDEF domain
E5E96_RS13155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5E96_RS13155	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E5E96_RS13165	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E5E96_RS13190	COG3098	single-species biofilm formation
E5E96_RS13195	COG0564	pseudouridine synthase activity
E5E96_RS13205	COG4580	involved in the transport of maltose and maltodextrins
E5E96_RS13215	COG1263	PTS System
E5E96_RS13215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_RS13225	COG2171	N-acyltransferase activity
E5E96_RS13230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5E96_RS13235	COG0024	Methionine aminopeptidase
E5E96_RS13240	COG0052	Belongs to the universal ribosomal protein uS2 family
E5E96_RS13245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E5E96_RS13250	COG0528	UMP kinase activity
E5E96_RS13255	COG0233	cytoplasmic translational termination
E5E96_RS13260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5E96_RS13265	COG0575	Belongs to the CDS family
E5E96_RS13270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E5E96_RS13275	COG0750	zinc metalloprotease
E5E96_RS13290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E96_RS13295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5E96_RS13300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E96_RS13305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E96_RS13310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5E96_RS13320	COG0825	malonyl-CoA metabolic process
E5E96_RS13325	COG3710	Transcriptional regulator
E5E96_RS13330	COG0531	amino acid
E5E96_RS13335	COG1982	Orn Lys Arg decarboxylase major
E5E96_RS13340	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E5E96_RS13355	COG0814	amino acid
E5E96_RS13365	COG1234	tRNA 3'-trailer cleavage
E5E96_RS13375	COG1073	alpha beta
E5E96_RS13380	COG1073	alpha beta
E5E96_RS13390	COG0531	amino acid
E5E96_RS13400	COG0488	(ABC) transporter
E5E96_RS13410	COG3590	peptidase
E5E96_RS13420	COG3706	GGDEF domain
E5E96_RS13455	COG0366	Alpha amylase catalytic
E5E96_RS13470	COG0463	Glycosyl transferase, family 2
E5E96_RS13485	COG2989	Protein conserved in bacteria
E5E96_RS13490	COG3108	Peptidase M15
E5E96_RS13500	COG2860	membrane
E5E96_RS13515	COG3115	cell septum assembly
E5E96_RS13520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5E96_RS13530	COG1328	CTP reductase activity
E5E96_RS13535	COG0602	queuosine metabolic process
E5E96_RS13565	COG1566	PFAM secretion protein HlyD family protein
E5E96_RS13570	COG1846	Transcriptional regulator
E5E96_RS13585	COG0281	malic enzyme
E5E96_RS13590	COG3290	protein histidine kinase activity
E5E96_RS13595	COG4565	transcriptional regulatory protein
E5E96_RS13600	COG0697	spore germination
E5E96_RS13610	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_RS13615	COG3284	Transcriptional regulator
E5E96_RS13620	COG1960	acyl-CoA dehydrogenase activity
E5E96_RS13625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5E96_RS13630	COG0346	lactoylglutathione lyase activity
E5E96_RS13635	COG0745	RESPONSE REGULATOR receiver
E5E96_RS13640	COG5002	protein histidine kinase activity
E5E96_RS13675	COG0545	Peptidyl-prolyl cis-trans isomerase
E5E96_RS13680	COG1131	(ABC) transporter
E5E96_RS13700	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E5E96_RS13720	COG0019	diaminopimelate decarboxylase activity
E5E96_RS13725	COG1115	amino acid carrier protein
E5E96_RS13730	COG0095	Lipoate-protein ligase
E5E96_RS13735	COG2233	PERMEase
E5E96_RS13750	COG0534	Mate efflux family protein
E5E96_RS13760	COG0281	malic enzyme
E5E96_RS13790	COG0733	neurotransmitter:sodium symporter activity
E5E96_RS13795	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5E96_RS13800	COG2199	diguanylate cyclase activity
E5E96_RS13800	COG2203	Gaf domain
E5E96_RS13805	COG1566	PFAM secretion protein HlyD family protein
E5E96_RS13810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E96_RS13820	COG1032	radical SAM domain protein
E5E96_RS13845	COG0673	inositol 2-dehydrogenase activity
E5E96_RS13855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E5E96_RS13860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5E96_RS13865	COG0739	heme binding
E5E96_RS13865	COG0741	lytic transglycosylase activity
E5E96_RS13865	COG1196	nuclear chromosome segregation
E5E96_RS13870	COG0366	Alpha amylase catalytic
E5E96_RS13890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5E96_RS13900	COG0788	formyltetrahydrofolate deformylase activity
E5E96_RS13905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5E96_RS13915	COG3118	belongs to the thioredoxin family
E5E96_RS13925	COG0791	NLP P60 protein
E5E96_RS13930	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E5E96_RS13945	COG1376	ErfK ybiS ycfS ynhG family protein
E5E96_RS13945	COG1388	LysM domain
E5E96_RS13970	COG4869	propanediol catabolic process
E5E96_RS13980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E96_RS13985	COG1882	Formate acetyltransferase
E5E96_RS13990	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_RS13990	COG1454	alcohol dehydrogenase
E5E96_RS14000	COG1454	alcohol dehydrogenase
E5E96_RS14000	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_RS14035	COG0583	DNA-binding transcription factor activity
E5E96_RS14040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5E96_RS14045	COG0243	molybdopterin cofactor binding
E5E96_RS14055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5E96_RS14065	COG1960	acyl-CoA dehydrogenase activity
E5E96_RS14070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5E96_RS14080	COG0469	pyruvate kinase activity
E5E96_RS14085	COG1737	Transcriptional regulator
E5E96_RS14100	COG0745	RESPONSE REGULATOR receiver
E5E96_RS14105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5E96_RS14120	COG1677	Flagellar hook-basal body complex protein FliE
E5E96_RS14130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E5E96_RS14185	COG1684	flagellar biosynthetic protein fliR
E5E96_RS14195	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E5E96_RS14220	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E5E96_RS14225	COG0643	Histidine kinase
E5E96_RS14225	COG0784	Response regulator, receiver
E5E96_RS14225	COG2198	Histidine kinase
E5E96_RS14230	COG2201	protein-glutamate methylesterase activity
E5E96_RS14235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5E96_RS14240	COG1360	Flagellar Motor Protein
E5E96_RS14245	COG1192	Involved in chromosome partitioning
E5E96_RS14255	COG0835	chemotaxis
E5E96_RS14270	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5E96_RS14275	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5E96_RS14280	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E5E96_RS14285	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E5E96_RS14290	COG1138	Cytochrome C-type biogenesis protein
E5E96_RS14295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5E96_RS14300	COG4235	cytochrome complex assembly
E5E96_RS14300	COG3088	subunit of a heme lyase
E5E96_RS14305	COG3088	subunit of a heme lyase
E5E96_RS14305	COG4235	cytochrome complex assembly
E5E96_RS14320	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5E96_RS14325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5E96_RS14325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5E96_RS14340	COG0259	pyridoxamine-phosphate oxidase activity
E5E96_RS14345	COG0625	glutathione transferase activity
E5E96_RS14355	COG3153	acetyltransferase
E5E96_RS14365	COG2850	peptidyl-arginine hydroxylation
E5E96_RS14370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5E96_RS14375	COG2915	High frequency lysogenization protein hflD homolog
E5E96_RS14380	COG0482	sulfurtransferase activity
E5E96_RS14390	COG1187	pseudouridine synthase activity
E5E96_RS14400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_RS14420	COG5599	Phosphatase
E5E96_RS14425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_RS14425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_RS14425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_RS14455	COG0456	acetyltransferase
E5E96_RS14465	COG0789	Transcriptional regulator
E5E96_RS14470	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5E96_RS14470	COG1902	pentaerythritol trinitrate reductase activity
E5E96_RS14475	COG1609	Transcriptional regulator
E5E96_RS14480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_RS14480	COG1263	PTS System
E5E96_RS14485	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5E96_RS14500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_RS14520	COG2207	Transcriptional regulator
E5E96_RS14525	COG0538	isocitrate dehydrogenase activity
E5E96_RS14535	COG3048	D-serine ammonia-lyase activity
E5E96_RS14540	COG2610	gluconate transmembrane transporter activity
E5E96_RS14545	COG0583	DNA-binding transcription factor activity
E5E96_RS14555	COG3171	Protein conserved in bacteria
E5E96_RS14570	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E5E96_RS14575	COG1715	Restriction endonuclease
E5E96_RS14585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5E96_RS14590	COG2867	negative regulation of translational initiation
E5E96_RS14600	COG0702	epimerase
E5E96_RS14605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5E96_RS14610	COG1454	alcohol dehydrogenase
E5E96_RS14620	COG0564	pseudouridine synthase activity
E5E96_RS14650	COG1280	lysine exporter protein (LysE YggA)
E5E96_RS14660	COG3263	regulation of cellular component size
E5E96_RS14670	COG3263	regulation of cellular component size
E5E96_RS14680	COG1876	peptidase activity
E5E96_RS14685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5E96_RS14690	COG1393	Belongs to the ArsC family
E5E96_RS14705	COG3069	C4-dicarboxylate transmembrane transporter activity
E5E96_RS14720	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E5E96_RS14725	COG0017	Asparaginyl-tRNA synthetase
E5E96_RS14745	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5E96_RS14750	COG0156	8-amino-7-oxononanoate synthase activity
E5E96_RS14755	COG2226	methyltransferase
E5E96_RS14755	COG1073	alpha beta
E5E96_RS14760	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E5E96_RS14765	COG0501	Belongs to the peptidase M48B family
E5E96_RS14775	COG0633	Ferredoxin
E5E96_RS14775	COG0633	Ferredoxin
E5E96_RS14775	COG3217	Mosc domain protein beta barrel domain protein
E5E96_RS14775	COG3217	Mosc domain protein beta barrel domain protein
E5E96_RS14805	COG0534	Mate efflux family protein
E5E96_RS14845	COG1309	transcriptional regulator
E5E96_RS14860	COG0791	NLP P60 protein
E5E96_RS14870	COG0583	DNA-binding transcription factor activity
E5E96_RS14875	COG0450	alkyl hydroperoxide reductase
E5E96_RS14895	COG0500	methyltransferase
E5E96_RS14900	COG4106	trans-aconitate 2-methyltransferase activity
E5E96_RS14905	COG1801	Protein of unknown function DUF72
E5E96_RS14910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5E96_RS14915	COG0217	transcriptional regulatory protein
E5E96_RS14920	COG2194	sulfuric ester hydrolase activity
E5E96_RS14925	COG1846	Transcriptional regulator
E5E96_RS14925	COG1940	carbohydrate kinase activity
E5E96_RS14930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5E96_RS14935	COG0363	glucosamine-6-phosphate deaminase activity
E5E96_RS14940	COG2190	(PTS) system
E5E96_RS14940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_RS14940	COG1263	PTS System
E5E96_RS14955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5E96_RS14960	COG0735	belongs to the Fur family
E5E96_RS14970	COG0716	FMN binding
E5E96_RS14990	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E5E96_RS14995	COG0033	Phosphoglucomutase
E5E96_RS15005	COG1846	Transcriptional regulator
E5E96_RS15020	COG2951	lytic endotransglycosylase activity
E5E96_RS15025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5E96_RS15030	COG4136	ATPase activity
E5E96_RS15050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5E96_RS15060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E96_RS15065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5E96_RS15075	COG0729	surface antigen
E5E96_RS15080	COG2911	Protein conserved in bacteria
E5E96_RS15100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E5E96_RS15110	COG0741	lytic transglycosylase activity
E5E96_RS15125	COG1607	acyl-coa hydrolase
E5E96_RS15135	COG3021	interspecies interaction between organisms
E5E96_RS15140	COG1388	LysM domain
E5E96_RS15140	COG0741	lytic transglycosylase activity
E5E96_RS15145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5E96_RS15150	COG2226	methyltransferase
E5E96_RS15155	COG0328	RNA-DNA hybrid ribonuclease activity
E5E96_RS15175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E5E96_RS15180	COG2716	regulation of RNA biosynthetic process
E5E96_RS15195	COG3852	Histidine kinase
E5E96_RS15205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5E96_RS15210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5E96_RS15215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5E96_RS15220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E5E96_RS15240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5E96_RS15255	COG0590	tRNA wobble adenosine to inosine editing
E5E96_RS15260	COG0573	inorganic phosphate transmembrane transporter activity
E5E96_RS15265	COG0581	inorganic phosphate transmembrane transporter activity
E5E96_RS15275	COG0704	Plays a role in the regulation of phosphate uptake
E5E96_RS15280	COG1253	flavin adenine dinucleotide binding
E5E96_RS15295	COG0531	amino acid
E5E96_RS15315	COG1126	abc transporter atp-binding protein
E5E96_RS15320	COG0765	amino acid transport
E5E96_RS15325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_RS15335	COG2271	Major facilitator Superfamily
E5E96_RS15350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5E96_RS15375	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E5E96_RS15380	COG0477	Major facilitator Superfamily
E5E96_RS15385	COG0123	including yeast histone deacetylase and acetoin utilization protein
E5E96_RS15395	COG1199	ATP-dependent helicase activity
E5E96_RS15410	COG1448	Aminotransferase
E5E96_RS15415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5E96_RS15425	COG0302	gtp cyclohydrolase
E5E96_RS15430	COG0840	transmembrane signaling receptor activity
E5E96_RS15435	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E5E96_RS15445	COG0583	DNA-binding transcription factor activity
E5E96_RS15475	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5E96_RS15485	COG1166	arginine decarboxylase activity
E5E96_RS15500	COG0840	transmembrane signaling receptor activity
E5E96_RS15505	COG0814	amino acid
E5E96_RS15515	COG3681	Belongs to the UPF0597 family
E5E96_RS15530	COG1403	HNH endonuclease
E5E96_RS15540	COG0346	lactoylglutathione lyase activity
E5E96_RS15555	COG1187	pseudouridine synthase activity
E5E96_RS15560	COG2807	transmembrane transport
E5E96_RS15570	COG0583	DNA-binding transcription factor activity
E5E96_RS15575	COG2271	Major facilitator Superfamily
E5E96_RS15605	COG2979	Protein of unknown function (DUF533)
E5E96_RS15610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5E96_RS15615	COG1271	oxidase subunit
E5E96_RS15620	COG1294	oxidase, subunit
E5E96_RS15630	COG2814	Major facilitator Superfamily
E5E96_RS15635	COG0656	L-ascorbic acid biosynthetic process
E5E96_RS15660	COG0583	DNA-binding transcription factor activity
E5E96_RS15665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5E96_RS15670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E5E96_RS15675	COG2271	Major facilitator Superfamily
E5E96_RS15680	COG1349	DNA-binding transcription factor activity
E5E96_RS15695	COG0584	glycerophosphoryl diester phosphodiesterase
E5E96_RS15700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E96_RS15705	COG1605	Chorismate mutase
E5E96_RS15705	COG0287	Prephenate dehydrogenase
E5E96_RS15710	COG0583	DNA-binding transcription factor activity
E5E96_RS15715	COG3085	chromosome segregation
E5E96_RS15720	COG4574	serine-type endopeptidase inhibitor activity
E5E96_RS15740	COG1770	oligopeptidase
E5E96_RS15745	COG4771	TonB-dependent receptor
E5E96_RS15750	COG3083	sulfuric ester hydrolase activity
E5E96_RS15755	COG3082	Protein of unknown function (DUF1414)
E5E96_RS15760	COG3081	Nucleoid-associated protein
E5E96_RS15770	COG1175	transmembrane transport
E5E96_RS15775	COG3833	ABC-type maltose transport systems, permease component
E5E96_RS15780	COG3842	ATPase activity
E5E96_RS15805	COG0425	Belongs to the sulfur carrier protein TusA family
E5E96_RS15810	COG4783	chaperone-mediated protein folding
E5E96_RS15820	COG1393	Belongs to the ArsC family
E5E96_RS15835	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
E5E96_RS15840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5E96_RS15845	COG2431	L-lysine efflux transmembrane transporter activity
E5E96_RS15855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_RS15875	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E96_RS15885	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5E96_RS15895	COG4953	penicillin-binding protein 1C
E5E96_RS15905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5E96_RS15905	COG0301	tRNA thio-modification
E5E96_RS15920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E5E96_RS15965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5E96_RS15985	COG0483	inositol monophosphate 1-phosphatase activity
E5E96_RS15995	COG0625	glutathione transferase activity
E5E96_RS16000	COG2814	Major facilitator Superfamily
E5E96_RS16020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5E96_RS16025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5E96_RS16030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E5E96_RS16035	COG0509	glycine decarboxylation via glycine cleavage system
E5E96_RS16040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5E96_RS16040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E5E96_RS16070	COG0798	PFAM Bile acid sodium symporter
E5E96_RS16075	COG1393	Belongs to the ArsC family
E5E96_RS16095	COG3634	alkyl hydroperoxide reductase activity
E5E96_RS16105	COG0517	IMP dehydrogenase activity
E5E96_RS16110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5E96_RS16115	COG0343	queuine tRNA-ribosyltransferase activity
E5E96_RS16120	COG1862	Preprotein translocase
E5E96_RS16125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E96_RS16130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E96_RS16145	COG0826	peptidase U32
E5E96_RS16150	COG0826	peptidase U32
E5E96_RS16155	COG3154	lipid carrier protein
E5E96_RS16175	COG1104	cysteine desulfurase activity
E5E96_RS16180	COG0822	iron-sulfur transferase activity
E5E96_RS16190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E5E96_RS16195	COG0443	Heat shock 70 kDa protein
E5E96_RS16200	COG0633	Ferredoxin
E5E96_RS16215	COG0105	UTP biosynthetic process
E5E96_RS16220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5E96_RS16235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5E96_RS16240	COG0124	histidyl-tRNA synthetase
E5E96_RS16245	COG2976	Protein conserved in bacteria
E5E96_RS16250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5E96_RS16255	COG1160	GTP binding
E5E96_RS16260	COG1645	bacterial-type flagellum-dependent swarming motility
E5E96_RS16265	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E5E96_RS16270	COG0047	phosphoribosylformylglycinamidine synthase activity
E5E96_RS16270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5E96_RS16275	COG2199	diguanylate cyclase activity
E5E96_RS16275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E96_RS16290	COG1007	ATP synthesis coupled electron transport
E5E96_RS16295	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_RS16305	COG0713	ATP synthesis coupled electron transport
E5E96_RS16310	COG0839	Belongs to the complex I subunit 6 family
E5E96_RS16315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_RS16320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5E96_RS16325	COG1034	ATP synthesis coupled electron transport
E5E96_RS16340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_RS16340	COG0649	NAD binding
E5E96_RS16345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_RS16350	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_RS16355	COG1360	Flagellar Motor Protein
E5E96_RS16360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E5E96_RS16375	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E5E96_RS16395	COG0724	RNA recognition motif
E5E96_RS16400	COG4989	oxidoreductase activity
E5E96_RS16425	COG3437	response regulator, receiver
E5E96_RS16430	COG0583	DNA-binding transcription factor activity
E5E96_RS16440	COG3300	MHYT domain
E5E96_RS16440	COG5001	Diguanylate cyclase
E5E96_RS16445	COG0778	Nitroreductase
E5E96_RS16465	COG0583	DNA-binding transcription factor activity
E5E96_RS16475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5E96_RS16480	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5E96_RS16485	COG0539	negative regulation of cytoplasmic translation
E5E96_RS16490	COG0776	regulation of translation
E5E96_RS16500	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E5E96_RS16520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5E96_RS16525	COG0602	queuosine metabolic process
E5E96_RS16530	COG3530	Putative quorum-sensing-regulated virulence factor
E5E96_RS16535	COG2096	Adenosyltransferase
E5E96_RS16540	COG2916	Histone family protein nucleoid-structuring protein H-NS
E5E96_RS16545	COG1757	Na H antiporter
E5E96_RS16550	COG1435	thymidine kinase activity
E5E96_RS16580	COG3501	Rhs element vgr protein
E5E96_RS16590	COG3209	COG3209 Rhs family protein
E5E96_RS16685	COG3501	Rhs element vgr protein
E5E96_RS16775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5E96_RS16780	COG1278	Cold shock
E5E96_RS16785	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5E96_RS16795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5E96_RS16800	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E5E96_RS16805	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5E96_RS16810	COG3134	Outer membrane lipoprotein
E5E96_RS16815	COG3706	GGDEF domain
E5E96_RS16820	COG0492	ferredoxin-NADP+ reductase activity
E5E96_RS16825	COG0686	Belongs to the AlaDH PNT family
E5E96_RS16835	COG1674	ftsk spoiiie
E5E96_RS16835	COG0531	amino acid
E5E96_RS16840	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E5E96_RS16845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5E96_RS16850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5E96_RS16855	COG1286	toxin biosynthetic process
E5E96_RS16860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5E96_RS16870	COG4172	Belongs to the ABC transporter superfamily
E5E96_RS16880	COG4171	peptide transport system, permease
E5E96_RS16885	COG4168	peptide transport system, permease
E5E96_RS16895	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E5E96_RS16900	COG1842	Phage shock protein A
E5E96_RS16915	COG3106	COG3106 Predicted ATPase
E5E96_RS16920	COG3768	UPF0283 membrane protein
E5E96_RS16930	COG2154	pterin-4-alpha-carbinolamine dehydratase
E5E96_RS16950	COG2199	diguanylate cyclase activity
E5E96_RS16955	COG2885	chlorophyll binding
E5E96_RS16960	COG0861	Integral membrane protein TerC family
E5E96_RS16975	COG1022	Amp-dependent synthetase and ligase
E5E96_RS16980	COG0295	cytidine deaminase activity
E5E96_RS16985	COG1346	cytolysis
E5E96_RS16990	COG1380	Effector of murein hydrolase LrgA
E5E96_RS16995	COG3345	alpha-galactosidase
E5E96_RS17005	COG2925	Exonuclease
E5E96_RS17010	COG2160	L-arabinose isomerase activity
E5E96_RS17020	COG1069	ribulokinase activity
E5E96_RS17025	COG1879	ABC-type sugar transport system periplasmic component
E5E96_RS17035	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5E96_RS17045	COG0583	DNA-binding transcription factor activity
E5E96_RS17055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5E96_RS17060	COG0254	rRNA binding
E5E96_RS17075	COG1451	nucleotide metabolic process
E5E96_RS17090	COG3069	C4-dicarboxylate transmembrane transporter activity
E5E96_RS17100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E96_RS17100	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E5E96_RS17105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5E96_RS17130	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E5E96_RS17135	COG1053	succinate dehydrogenase
E5E96_RS17145	COG0567	Dehydrogenase, E1 component
E5E96_RS17150	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5E96_RS17155	COG0045	succinate-CoA ligase (ADP-forming) activity
E5E96_RS17160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E5E96_RS17170	COG2983	Belongs to the UPF0260 family
E5E96_RS17175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E96_RS17185	COG3842	ATPase activity
E5E96_RS17190	COG1840	ABC-type Fe3 transport system, periplasmic component
E5E96_RS17200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E5E96_RS17210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E96_RS17215	COG1882	Formate acetyltransferase
E5E96_RS17220	COG2116	formate transmembrane transporter activity
E5E96_RS17225	COG1944	ATP diphosphatase activity
E5E96_RS17235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5E96_RS17240	COG0612	Peptidase, M16
E5E96_RS17255	COG2910	NAD(P)H-binding
E5E96_RS17260	COG0583	DNA-binding transcription factor activity
E5E96_RS17275	COG4774	siderophore transport
E5E96_RS17290	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5E96_RS17300	COG0516	GMP reductase activity
E5E96_RS17300	COG0517	IMP dehydrogenase activity
E5E96_RS17330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5E96_RS17345	COG3033	Beta-eliminating lyase
E5E96_RS17355	COG1051	belongs to the nudix hydrolase family
E5E96_RS17360	COG4235	cytochrome complex assembly
E5E96_RS17360	COG3088	subunit of a heme lyase
E5E96_RS17365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5E96_RS17370	COG1138	Cytochrome C-type biogenesis protein
E5E96_RS17375	COG3301	Polysulphide reductase, NrfD
E5E96_RS17380	COG0437	4 iron, 4 sulfur cluster binding
E5E96_RS17385	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E5E96_RS17395	COG0247	lactate metabolic process
E5E96_RS17400	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E5E96_RS17405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E5E96_RS17410	COG3012	SEC-C Motif Domain Protein
E5E96_RS17415	COG0840	transmembrane signaling receptor activity
E5E96_RS17420	COG1940	carbohydrate kinase activity
E5E96_RS17420	COG1846	Transcriptional regulator
E5E96_RS17430	COG4565	transcriptional regulatory protein
E5E96_RS17455	COG0569	domain protein
E5E96_RS17455	COG2985	domain, Protein
E5E96_RS17465	COG0556	nucleotide-excision repair
E5E96_RS17475	COG0586	Pfam SNARE associated Golgi protein
E5E96_RS17480	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5E96_RS17485	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5E96_RS17490	COG2186	Transcriptional regulator
E5E96_RS17495	COG2719	SpoVR family
E5E96_RS17505	COG2766	serine protein kinase
E5E96_RS17510	COG0514	ATP-dependent DNA helicase (RecQ)
E5E96_RS17515	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E5E96_RS17520	COG0814	amino acid
E5E96_RS17550	COG0058	SHG alpha-glucan phosphorylase activity
E5E96_RS17555	COG0471	metal ion transport
E5E96_RS17560	COG3118	belongs to the thioredoxin family
E5E96_RS17575	COG1132	(ABC) transporter
E5E96_RS17585	COG2501	S4 domain
E5E96_RS17595	COG3243	poly(R)-hydroxyalkanoic acid synthase
E5E96_RS17620	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E5E96_RS17625	COG2329	Antibiotic biosynthesis monooxygenase
E5E96_RS17655	COG1742	UPF0060 membrane protein
E5E96_RS17665	COG0456	acetyltransferase
E5E96_RS17670	COG0513	Belongs to the DEAD box helicase family
E5E96_RS17675	COG0386	Belongs to the glutathione peroxidase family
E5E96_RS17685	COG1181	Belongs to the D-alanine--D-alanine ligase family
E5E96_RS17705	COG0583	DNA-binding transcription factor activity
E5E96_RS17720	COG3593	DNA synthesis involved in DNA repair
E5E96_RS17775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5E96_RS17780	COG1011	Hydrolase
E5E96_RS17785	COG1473	amidohydrolase
E5E96_RS17790	COG0205	6-phosphofructokinase activity
E5E96_RS17800	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E5E96_RS17805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5E96_RS17815	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E5E96_RS17820	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E5E96_RS17835	COG0242	peptide deformylase activity
E5E96_RS17865	COG0384	phenazine biosynthesis protein PhzF
E5E96_RS17880	COG2824	Alkylphosphonate utilization operon protein PhnA
E5E96_RS17905	COG0588	phosphoglycerate mutase activity
E5E96_RS17910	COG3706	GGDEF domain
E5E96_RS17920	COG2840	Smr protein MutS2
E5E96_RS17925	COG2890	protein-(glutamine-N5) methyltransferase activity
E5E96_RS17930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E5E96_RS17940	COG0513	Belongs to the DEAD box helicase family
E5E96_RS17945	COG5654	RES domain protein
E5E96_RS17955	COG0814	amino acid
E5E96_RS17960	COG1609	Transcriptional regulator
E5E96_RS17965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_RS17965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_RS17970	COG1105	Belongs to the carbohydrate kinase PfkB family
E5E96_RS17975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_RS17975	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E5E96_RS17975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5E96_RS17980	COG2140	Oxalate decarboxylase
E5E96_RS17985	COG1609	Transcriptional regulator
E5E96_RS18000	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E5E96_RS18000	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5E96_RS18005	COG3715	PTS system
E5E96_RS18010	COG3716	PTS system mannose fructose sorbose family IID component
E5E96_RS18015	COG2942	2-epimerase
E5E96_RS18020	COG3313	Fe-S protein
E5E96_RS18025	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E5E96_RS18030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5E96_RS18035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5E96_RS18040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5E96_RS18050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5E96_RS18075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5E96_RS18080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5E96_RS18085	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E5E96_RS18090	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5E96_RS18095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5E96_RS18100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E96_RS18100	COG0072	phenylalanine-tRNA ligase activity
E5E96_RS18105	COG0776	regulation of translation
E5E96_RS18135	COG2199	diguanylate cyclase activity
E5E96_RS18140	COG1609	Transcriptional regulator
E5E96_RS18145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E96_RS18150	COG1879	ABC-type sugar transport system periplasmic component
E5E96_RS18155	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5E96_RS18160	COG1129	ABC transporter
E5E96_RS18165	COG1869	D-ribose catabolic process
E5E96_RS18185	COG0037	tRNA processing
E5E96_RS18190	COG0589	response to stress
E5E96_RS18195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5E96_RS18220	COG2010	Cytochrome c
E5E96_RS18235	COG3278	Belongs to the heme-copper respiratory oxidase family
E5E96_RS18245	COG1956	GAF domain-containing protein
E5E96_RS18250	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
E5E96_RS18260	COG0308	aminopeptidase N
E5E96_RS18270	COG2902	Dehydrogenase
E5E96_RS18275	COG0167	dihydroorotate dehydrogenase activity
E5E96_RS18295	COG0488	(ABC) transporter
E5E96_RS18310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5E96_RS18315	COG1067	ATP-dependent peptidase activity
E5E96_RS18355	COG4128	Pfam Zonular occludens toxin
E5E96_RS18375	COG3141	response to X-ray
E5E96_RS18385	COG4221	oxidoreductase activity
E5E96_RS18430	COG0372	Belongs to the citrate synthase family
E5E96_RS18435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E5E96_RS18445	COG2995	paraquat-inducible protein a
E5E96_RS18450	COG3008	intermembrane lipid transfer
E5E96_RS18455	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E5E96_RS18455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5E96_RS18500	COG0084	hydrolase, TatD family'
E5E96_RS18505	COG0470	DNA polymerase III
E5E96_RS18510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E5E96_RS18515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5E96_RS18520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5E96_RS18530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5E96_RS18535	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_RS18545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5E96_RS18550	COG0416	fatty acid biosynthetic process
E5E96_RS18555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5E96_RS18560	COG1399	metal-binding, possibly nucleic acid-binding protein
E5E96_RS18575	COG2814	Major facilitator Superfamily
E5E96_RS18580	COG0424	maF-like protein
E5E96_RS18585	COG0546	phosphoglycolate phosphatase activity
E5E96_RS18590	COG0564	pseudouridine synthase activity
E5E96_RS18595	COG1530	ribonuclease E activity
E5E96_RS18600	COG0306	phosphate transporter
E5E96_RS18605	COG0717	Belongs to the dCTP deaminase family
E5E96_RS18610	COG0572	uridine kinase
E5E96_RS18615	COG0489	protein tyrosine kinase activity
E5E96_RS18620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E96_RS18620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5E96_RS18625	COG0625	glutathione transferase activity
E5E96_RS18630	COG1254	Belongs to the acylphosphatase family
E5E96_RS18635	COG0840	transmembrane signaling receptor activity
E5E96_RS18640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5E96_RS18655	COG0709	Synthesizes selenophosphate from selenide and ATP
E5E96_RS18660	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E5E96_RS18665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5E96_RS18670	COG3437	response regulator, receiver
E5E96_RS18680	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5E96_RS18690	COG1643	Atp-dependent helicase
E5E96_RS18695	COG0517	IMP dehydrogenase activity
E5E96_RS18695	COG0617	tRNA 3'-terminal CCA addition
E5E96_RS18695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5E96_RS18710	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5E96_RS18720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5E96_RS18725	COG2832	Protein of unknown function (DUF454)
E5E96_RS18730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5E96_RS18745	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E5E96_RS18750	COG0318	PFAM AMP-dependent synthetase and ligase
E5E96_RS18755	COG2226	methyltransferase
E5E96_RS18755	COG0596	Alpha beta hydrolase
E5E96_RS18755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5E96_RS18765	COG1214	PFAM Peptidase M22, glycoprotease
E5E96_RS18770	COG1199	ATP-dependent helicase activity
E5E96_RS18780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5E96_RS18785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5E96_RS18790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5E96_RS18795	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E5E96_RS18795	COG0131	Imidazoleglycerol-phosphate dehydratase
E5E96_RS18800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5E96_RS18805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E5E96_RS18820	COG2198	Histidine kinase
E5E96_RS18820	COG0784	Response regulator, receiver
E5E96_RS18820	COG2205	protein histidine kinase activity
E5E96_RS18825	COG0107	imidazoleglycerol-phosphate synthase activity
E5E96_RS18830	COG0140	phosphoribosyl-ATP diphosphatase activity
E5E96_RS18830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5E96_RS18840	COG2378	regulation of single-species biofilm formation
E5E96_RS18845	COG0318	PFAM AMP-dependent synthetase and ligase
E5E96_RS18850	COG1288	antiporter activity
E5E96_RS18860	COG3134	Outer membrane lipoprotein
E5E96_RS18870	COG2080	2 iron, 2 sulfur cluster binding
E5E96_RS18875	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E5E96_RS18880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5E96_RS18885	COG2252	PERMEase
E5E96_RS18890	COG0402	S-adenosylhomocysteine deaminase activity
E5E96_RS18895	COG2233	PERMEase
E5E96_RS18910	COG0402	S-adenosylhomocysteine deaminase activity
E5E96_RS18915	COG0493	'glutamate synthase
E5E96_RS18915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_RS18920	COG2068	MobA-Related Protein
E5E96_RS18925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5E96_RS18930	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5E96_RS18930	COG3608	succinylglutamate desuccinylase aspartoacylase
E5E96_RS18935	COG0697	spore germination
E5E96_RS18940	COG0549	Belongs to the carbamate kinase family
E5E96_RS18950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5E96_RS18955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5E96_RS18960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5E96_RS18985	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5E96_RS18985	COG1024	Enoyl-CoA hydratase
E5E96_RS18990	COG0183	Belongs to the thiolase family
E5E96_RS18995	COG0714	Associated with various cellular activities
E5E96_RS19025	COG1595	DNA-templated transcription, initiation
E5E96_RS19040	COG2067	long-chain fatty acid transport protein
E5E96_RS19065	COG3123	guanosine phosphorylase activity
E5E96_RS19070	COG1760	l-serine dehydratase
E5E96_RS19075	COG1760	l-serine dehydratase
E5E96_RS19080	COG2951	lytic endotransglycosylase activity
E5E96_RS19085	COG3100	YcgL domain-containing protein
E5E96_RS19095	COG2894	cell division
E5E96_RS19100	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E5E96_RS19105	COG3099	Belongs to the UPF0263 family
E5E96_RS19110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5E96_RS19150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5E96_RS19155	COG0697	spore germination
E5E96_RS19160	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E5E96_RS19165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5E96_RS19175	COG0307	riboflavin synthase, alpha
E5E96_RS19185	COG0534	Mate efflux family protein
E5E96_RS19215	COG0417	DNA replication proofreading
E5E96_RS19240	COG1560	Kdo2-lipid A biosynthetic process
E5E96_RS19245	COG1560	Kdo2-lipid A biosynthetic process
E5E96_RS19255	COG0583	DNA-binding transcription factor activity
E5E96_RS19260	COG0673	inositol 2-dehydrogenase activity
E5E96_RS19265	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E5E96_RS19270	COG0583	DNA-binding transcription factor activity
E5E96_RS19280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E96_RS19290	COG3300	MHYT domain
E5E96_RS19290	COG5001	Diguanylate cyclase
E5E96_RS19295	COG2723	6-phospho-beta-galactosidase activity
E5E96_RS19300	COG0583	DNA-binding transcription factor activity
E5E96_RS19340	COG2003	Belongs to the UPF0758 family
E5E96_RS19365	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E5E96_RS19380	COG0582	viral genome integration into host DNA
E5E96_RS19390	COG0730	response to heat
E5E96_RS19400	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_RS19410	COG1024	Enoyl-CoA hydratase
E5E96_RS19420	COG1960	acyl-CoA dehydrogenase activity
E5E96_RS19430	COG1960	acyl-CoA dehydrogenase activity
E5E96_RS19435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5E96_RS19470	COG1584	GPR1 FUN34 yaaH family protein
E5E96_RS19485	COG1115	amino acid carrier protein
E5E96_RS19525	COG1024	Enoyl-CoA hydratase
E5E96_RS19540	COG3162	membrane
E5E96_RS19545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5E96_RS19550	COG0488	(ABC) transporter
E5E96_RS19555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5E96_RS19560	COG0776	regulation of translation
E5E96_RS19565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5E96_RS19570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5E96_RS19575	COG0740	serine-type endopeptidase activity
E5E96_RS19580	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5E96_RS19590	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E5E96_RS19595	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5E96_RS19600	COG1136	(ABC) transporter
E5E96_RS19605	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5E96_RS19620	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E5E96_RS19625	COG4166	transmembrane transport
E5E96_RS19630	COG0697	spore germination
E5E96_RS19640	COG2062	phosphohistidine phosphatase, SixA
E5E96_RS19650	COG0500	methyltransferase
E5E96_RS19690	COG0519	Catalyzes the synthesis of GMP from XMP
E5E96_RS19690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5E96_RS19695	COG0516	GMP reductase activity
E5E96_RS19695	COG0517	IMP dehydrogenase activity
E5E96_RS19700	COG3158	transport of potassium into the cell
E5E96_RS19720	COG0697	spore germination
E5E96_RS19725	COG1570	exodeoxyribonuclease VII activity
E5E96_RS19740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E96_RS19745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5E96_RS19750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E5E96_RS19790	COG4771	TonB-dependent receptor
E5E96_RS19795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5E96_RS19800	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5E96_RS19805	COG1120	ATPase activity
E5E96_RS19810	COG2977	Belongs to the P-Pant transferase superfamily
E5E96_RS19815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E5E96_RS19820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5E96_RS19830	COG1028	Short-chain dehydrogenase reductase Sdr
E5E96_RS19835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5E96_RS19840	COG3433	isochorismatase activity
E5E96_RS19840	COG1535	isochorismatase
E5E96_RS19845	COG1021	2,3-dihydroxybenzoate-AMP ligase
E5E96_RS19865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5E96_RS19870	COG3300	MHYT domain
E5E96_RS19870	COG5001	Diguanylate cyclase
E5E96_RS19885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5E96_RS19890	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E5E96_RS19895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E5E96_RS19900	COG0563	adenylate kinase activity
E5E96_RS19905	COG0326	Molecular chaperone. Has ATPase activity
E5E96_RS19910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5E96_RS19935	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_RS19945	COG3158	transport of potassium into the cell
E5E96_RS19950	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_RS19955	COG0651	ATP synthesis coupled electron transport
E5E96_RS19960	COG0650	Formate hydrogenlyase subunit 4
E5E96_RS19965	COG3261	NADH dehydrogenase
E5E96_RS19965	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E5E96_RS19970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5E96_RS19975	COG3260	NADH ubiquinone oxidoreductase 20
E5E96_RS19995	COG1921	L-seryl-tRNASec selenium transferase activity
E5E96_RS20005	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E5E96_RS20010	COG0298	carbon dioxide binding
E5E96_RS20020	COG0309	Hydrogenase expression formation protein (HypE)
E5E96_RS20025	COG0375	protein maturation
E5E96_RS20030	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E5E96_RS20035	COG3842	ATPase activity
E5E96_RS20045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5E96_RS20050	COG0601	transmembrane transport
E5E96_RS20060	COG1773	rubredoxin
E5E96_RS20065	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E5E96_RS20070	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E5E96_RS20075	COG5557	Pfam Polysulphide reductase, NrfD
E5E96_RS20080	COG0437	4 iron, 4 sulfur cluster binding
E5E96_RS20085	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E5E96_RS20100	COG0643	Histidine kinase
E5E96_RS20100	COG2198	Histidine kinase
E5E96_RS20105	COG0840	transmembrane signaling receptor activity
E5E96_RS20105	COG3290	protein histidine kinase activity
E5E96_RS20110	COG0835	chemotaxis
E5E96_RS20120	COG2201	protein-glutamate methylesterase activity
E5E96_RS20130	COG0840	transmembrane signaling receptor activity
E5E96_RS20135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5E96_RS20160	COG0659	secondary active sulfate transmembrane transporter activity
E5E96_RS20190	COG0672	)-iron permease
E5E96_RS20210	COG2814	Major facilitator Superfamily
E5E96_RS20265	COG1139	Iron-sulfur cluster binding protein
E5E96_RS20275	COG1620	l-lactate permease
E5E96_RS20280	COG0583	DNA-binding transcription factor activity
E5E96_RS20290	COG0346	lactoylglutathione lyase activity
E5E96_RS20295	COG0596	Alpha beta hydrolase
E5E96_RS20315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5E96_RS20320	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E5E96_RS20320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5E96_RS20325	COG0527	aspartate kinase activity
E5E96_RS20335	COG1368	sulfuric ester hydrolase activity
E5E96_RS20340	COG1619	proteins homologs of microcin C7 resistance protein MccF
E5E96_RS20345	COG4667	esterase of the alpha-beta hydrolase superfamily
E5E96_RS20360	COG0393	Putative heavy-metal-binding
E5E96_RS20380	COG1252	NADH dehydrogenase
E5E96_RS20385	COG3150	esterase
E5E96_RS20390	COG2233	PERMEase
E5E96_RS20415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E96_RS20420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5E96_RS20455	COG0537	adenosine 5'-monophosphoramidase activity
E5E96_RS20470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5E96_RS20485	COG1301	dicarboxylic acid transport
E5E96_RS20495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5E96_RS20500	COG0861	Integral membrane protein TerC family
E5E96_RS20515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5E96_RS20520	COG0601	transmembrane transport
E5E96_RS20530	COG2095	MarC family integral membrane protein
E5E96_RS20540	COG1454	alcohol dehydrogenase
E5E96_RS20540	COG1012	belongs to the aldehyde dehydrogenase family
E5E96_RS20545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5E96_RS20545	COG2199	diguanylate cyclase activity
E5E96_RS20550	COG3275	phosphorelay sensor kinase activity
E5E96_RS20555	COG3279	Response regulator of the LytR AlgR family
E5E96_RS20560	COG1966	Carbon starvation protein
E5E96_RS20570	COG1566	PFAM secretion protein HlyD family protein
E5E96_RS20575	COG1061	Type III restriction enzyme res subunit
E5E96_RS20580	COG2027	D-alanyl-D-alanine carboxypeptidase
E5E96_RS20585	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5E96_RS20595	COG0436	Aminotransferase
E5E96_RS20600	COG1288	antiporter activity
E5E96_RS20605	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5E96_RS20670	COG4397	Mu-like prophage major head subunit gpT
E5E96_RS20675	COG4388	Caudovirus prohead serine protease
E5E96_RS20680	COG2203	Gaf domain
E5E96_RS20680	COG4251	negative regulation of phosphorylation
E5E96_RS20680	COG3706	GGDEF domain
E5E96_RS20680	COG5001	Diguanylate cyclase
E5E96_RS20700	COG4383	Mu-like prophage protein gp29
E5E96_RS20715	COG0640	Transcriptional regulator
E5E96_RS20820	COG2932	Transcriptional regulator
E5E96_RS20835	COG0697	spore germination
E5E96_RS20840	COG4657	Part of a membrane complex involved in electron transport
E5E96_RS20845	COG2878	Part of a membrane complex involved in electron transport
E5E96_RS20855	COG4658	electron transport chain
E5E96_RS20860	COG4659	FMN binding
E5E96_RS20865	COG4660	Part of a membrane complex involved in electron transport
E5E96_RS20870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5E96_RS20875	COG0346	lactoylglutathione lyase activity
E5E96_RS20890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5E96_RS20895	COG2056	Na+-H+ antiporter family
E5E96_RS20905	COG2050	protein possibly involved in aromatic compounds catabolism
E5E96_RS20915	COG0277	FAD linked oxidase domain protein
E5E96_RS20915	COG0247	lactate metabolic process
E5E96_RS20925	COG1253	flavin adenine dinucleotide binding
E5E96_RS20930	COG1902	pentaerythritol trinitrate reductase activity
E5E96_RS20935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5E96_RS20940	COG0647	UMP catabolic process
E5E96_RS20945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5E96_RS20945	COG4651	solute:proton antiporter activity
E5E96_RS20955	COG0367	asparagine synthase
E5E96_RS20965	COG0625	glutathione transferase activity
E5E96_RS20970	COG0625	glutathione transferase activity
E5E96_RS20980	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E5E96_RS20995	COG0564	pseudouridine synthase activity
E5E96_RS21000	COG5001	Diguanylate cyclase
E5E96_RS21005	COG0840	transmembrane signaling receptor activity
E5E96_RS21015	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E5E96_RS21015	COG0392	lysyltransferase activity
E5E96_RS21020	COG2194	sulfuric ester hydrolase activity
E5E96_RS21035	COG1317	bacterial-type flagellum organization
E5E96_RS21195	COG4790	Type iii secretion
E5E96_RS21200	COG4794	Type iii secretion
E5E96_RS21205	COG4791	protein targeting
E5E96_RS21210	COG4792	protein secretion
E5E96_RS21285	COG1358	cellular component organization or biogenesis
E5E96_RS21335	COG3039	Transposase
E5E96_RS21355	COG0670	Belongs to the BI1 family
E5E96_RS21360	COG1289	transmembrane transporter activity
E5E96_RS21365	COG2920	part of a sulfur-relay system
E5E96_RS21370	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E5E96_RS21375	COG0285	dihydrofolate synthase activity
E5E96_RS21380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5E96_RS21385	COG0101	tRNA pseudouridine synthase activity
E5E96_RS21395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E5E96_RS21400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5E96_RS21405	COG0671	phosphoesterase, PA-phosphatase related
E5E96_RS21410	COG1464	Belongs to the NlpA lipoprotein family
E5E96_RS21440	COG0574	Belongs to the PEP-utilizing enzyme family
E5E96_RS21440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5E96_RS21445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E5E96_RS21515	COG1242	4 iron, 4 sulfur cluster binding
E5E96_RS21520	COG0067	glutamate synthase
E5E96_RS21520	COG0069	glutamate synthase activity
E5E96_RS21520	COG0070	glutamate synthase
E5E96_RS21525	COG0493	'glutamate synthase
E5E96_RS21535	COG0765	amino acid transport
E5E96_RS21540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_RS21555	COG0789	Transcriptional regulator
E5E96_RS21570	COG4104	PAAR repeat-containing protein
E5E96_RS21580	COG0513	Belongs to the DEAD box helicase family
E5E96_RS21585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5E96_RS21620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5E96_RS21625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5E96_RS21630	COG0505	Belongs to the CarA family
E5E96_RS21635	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5E96_RS21645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5E96_RS21650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5E96_RS21655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5E96_RS21660	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E5E96_RS21665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5E96_RS21675	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
E5E96_RS21685	COG2205	protein histidine kinase activity
E5E96_RS21685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5E96_RS21700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5E96_RS21725	COG0023	Translation Initiation Factor
E5E96_RS21730	COG2119	membrane
E5E96_RS21760	COG2203	Gaf domain
E5E96_RS21760	COG2199	diguanylate cyclase activity
E5E96_RS21790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5E96_RS21800	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5E96_RS21805	COG3301	Polysulphide reductase, NrfD
E5E96_RS21810	COG0437	4 iron, 4 sulfur cluster binding
E5E96_RS21815	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E5E96_RS21865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5E96_RS21900	COG2197	response regulator
E5E96_RS21905	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E5E96_RS21910	COG2835	tetraacyldisaccharide 4'-kinase activity
E5E96_RS21915	COG1663	tetraacyldisaccharide 4'-kinase activity
E5E96_RS21925	COG0658	competence protein
E5E96_RS21925	COG2333	competence protein COMEC
E5E96_RS21940	COG0433	COG0433 Predicted ATPase
E5E96_RS21965	COG2267	carboxylic ester hydrolase activity
E5E96_RS21970	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E5E96_RS21985	COG0314	molybdopterin synthase activity
E5E96_RS21990	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E5E96_RS21995	COG0315	cyclic pyranopterin monophosphate synthase activity
E5E96_RS22000	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5E96_RS22005	COG3005	denitrification pathway
E5E96_RS22015	COG0348	domain, Protein
E5E96_RS22020	COG0437	4 iron, 4 sulfur cluster binding
E5E96_RS22025	COG0243	molybdopterin cofactor binding
E5E96_RS22035	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_RS22035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5E96_RS22040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5E96_RS22050	COG2197	response regulator
E5E96_RS22070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E5E96_RS22080	COG0121	glutamine amidotransferase
E5E96_RS22085	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E5E96_RS22090	COG1960	acyl-CoA dehydrogenase activity
E5E96_RS22100	COG0784	Response regulator, receiver
E5E96_RS22100	COG3437	response regulator, receiver
E5E96_RS22105	COG2239	Acts as a magnesium transporter
E5E96_RS22120	COG1705	Flagellar rod assembly protein muramidase FlgJ
E5E96_RS22120	COG3951	Flagellar rod assembly protein muramidase FlgJ
E5E96_RS22125	COG1706	bacterial-type flagellum-dependent cell motility
E5E96_RS22130	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E5E96_RS22140	COG4787	bacterial-type flagellum-dependent cell motility
E5E96_RS22160	COG1815	bacterial-type flagellum-dependent cell motility
E5E96_RS22165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E5E96_RS22170	COG0835	chemotaxis
E5E96_RS22170	COG0784	Response regulator, receiver
E5E96_RS22175	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E5E96_RS22190	COG0622	Phosphoesterase
E5E96_RS22220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5E96_RS22225	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5E96_RS22230	COG1882	Formate acetyltransferase
E5E96_RS22235	COG1349	DNA-binding transcription factor activity
E5E96_RS22270	COG1278	Cold shock
E5E96_RS22310	COG3132	Protein of unknown function, DUF480
E5E96_RS22330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5E96_RS22350	COG0110	maltose O-acetyltransferase activity
E5E96_RS22370	COG0110	maltose O-acetyltransferase activity
E5E96_RS22395	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis