locus-tag	class	description
C2U37_RS00005	COG0745	RESPONSE REGULATOR receiver
C2U37_RS00015	COG0708	Exodeoxyribonuclease III
C2U37_RS00025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_RS00030	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_RS00045	COG0095	Lipoate-protein ligase
C2U37_RS00065	COG2391	methyltransferase activity
C2U37_RS00075	COG0640	Transcriptional regulator
C2U37_RS00085	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U37_RS00095	COG1285	pathogenesis
C2U37_RS00125	COG0484	heat shock protein binding
C2U37_RS00130	COG0443	Heat shock 70 kDa protein
C2U37_RS00135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2U37_RS00140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U37_RS00145	COG3706	GGDEF domain
C2U37_RS00150	COG0497	DNA recombination
C2U37_RS00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_RS00165	COG1136	(ABC) transporter
C2U37_RS00165	COG0577	efflux transmembrane transporter activity
C2U37_RS00170	COG1538	Outer membrane efflux protein
C2U37_RS00175	COG2375	cellular response to nickel ion
C2U37_RS00180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U37_RS00185	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U37_RS00190	COG0583	DNA-binding transcription factor activity
C2U37_RS00195	COG3048	D-serine ammonia-lyase activity
C2U37_RS00205	COG0538	isocitrate dehydrogenase activity
C2U37_RS00235	COG0456	acetyltransferase
C2U37_RS00240	COG1187	pseudouridine synthase activity
C2U37_RS00250	COG0482	sulfurtransferase activity
C2U37_RS00255	COG2915	High frequency lysogenization protein hflD homolog
C2U37_RS00260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U37_RS00265	COG2850	peptidyl-arginine hydroxylation
C2U37_RS00275	COG1196	nuclear chromosome segregation
C2U37_RS00275	COG3264	Mechanosensitive ion channel
C2U37_RS00305	COG0281	malic enzyme
C2U37_RS00310	COG0746	molybdenum cofactor guanylyltransferase activity
C2U37_RS00315	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2U37_RS00320	COG1289	transmembrane transporter activity
C2U37_RS00325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U37_RS00355	COG3220	belongs to the UPF0276 family
C2U37_RS00365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U37_RS00380	COG3039	Transposase
C2U37_RS00400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U37_RS00405	COG0083	homoserine kinase activity
C2U37_RS00420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2U37_RS00425	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2U37_RS00440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U37_RS00450	COG0745	RESPONSE REGULATOR receiver
C2U37_RS00465	COG4988	ABC transporter
C2U37_RS00470	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2U37_RS00490	COG1720	tRNA m6t6A37 methyltransferase activity
C2U37_RS00505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U37_RS00510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U37_RS00515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_RS00525	COG2190	(PTS) system
C2U37_RS00540	COG0420	3'-5' exonuclease activity
C2U37_RS00545	COG1247	-acetyltransferase
C2U37_RS00550	COG2974	May be involved in recombination
C2U37_RS00560	COG0405	Gamma-glutamyltransferase
C2U37_RS00565	COG4651	solute:proton antiporter activity
C2U37_RS00565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U37_RS00600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U37_RS00605	COG1917	Cupin 2, conserved barrel domain protein
C2U37_RS00605	COG1396	sequence-specific DNA binding
C2U37_RS00625	COG0531	amino acid
C2U37_RS00630	COG0531	amino acid
C2U37_RS00640	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2U37_RS00650	COG3384	dioxygenase
C2U37_RS00680	COG2205	protein histidine kinase activity
C2U37_RS00680	COG0784	Response regulator, receiver
C2U37_RS00690	COG1376	ErfK ybiS ycfS ynhG family protein
C2U37_RS00690	COG1388	LysM domain
C2U37_RS00705	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C2U37_RS00710	COG0791	NLP P60 protein
C2U37_RS00720	COG3118	belongs to the thioredoxin family
C2U37_RS00730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U37_RS00735	COG0788	formyltetrahydrofolate deformylase activity
C2U37_RS00760	COG0739	heme binding
C2U37_RS00760	COG1196	nuclear chromosome segregation
C2U37_RS00760	COG0741	lytic transglycosylase activity
C2U37_RS00770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2U37_RS00775	COG0673	inositol 2-dehydrogenase activity
C2U37_RS00815	COG1032	radical SAM domain protein
C2U37_RS00820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_RS00830	COG3706	GGDEF domain
C2U37_RS00835	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U37_RS00840	COG0733	neurotransmitter:sodium symporter activity
C2U37_RS00870	COG0281	malic enzyme
C2U37_RS00875	COG2207	Transcriptional regulator
C2U37_RS00880	COG0534	Mate efflux family protein
C2U37_RS00895	COG2233	PERMEase
C2U37_RS00900	COG0095	Lipoate-protein ligase
C2U37_RS00905	COG1115	amino acid carrier protein
C2U37_RS00910	COG0019	diaminopimelate decarboxylase activity
C2U37_RS00920	COG0678	peroxiredoxin activity
C2U37_RS00925	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2U37_RS00935	COG1126	abc transporter atp-binding protein
C2U37_RS00940	COG0765	amino acid transport
C2U37_RS00945	COG4597	amino acid ABC transporter
C2U37_RS00950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_RS00965	COG1131	(ABC) transporter
C2U37_RS00970	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U37_RS00985	COG1940	carbohydrate kinase activity
C2U37_RS00995	COG4783	chaperone-mediated protein folding
C2U37_RS01005	COG5002	protein histidine kinase activity
C2U37_RS01010	COG0745	RESPONSE REGULATOR receiver
C2U37_RS01015	COG0346	lactoylglutathione lyase activity
C2U37_RS01020	COG3706	GGDEF domain
C2U37_RS01025	COG3284	Transcriptional regulator
C2U37_RS01040	COG0697	spore germination
C2U37_RS01050	COG0667	Aldo Keto reductase
C2U37_RS01065	COG3290	protein histidine kinase activity
C2U37_RS01080	COG4644	lycopene metabolic process
C2U37_RS01095	COG0840	transmembrane signaling receptor activity
C2U37_RS01180	COG1475	DNA binding
C2U37_RS01195	COG5489	Protein of unknown function (DUF736)
C2U37_RS01250	COG4959	Type IV secretory pathway protease TraF
C2U37_RS01265	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U37_RS01285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_RS01290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_RS01305	COG0583	DNA-binding transcription factor activity
C2U37_RS01325	COG4962	Type ii secretion system protein e
C2U37_RS01330	COG3838	Conjugal transfer protein Trbc
C2U37_RS01340	COG3451	type IV secretory pathway VirB4
C2U37_RS01355	COG3846	protein secretion by the type IV secretion system
C2U37_RS01395	COG0602	queuosine metabolic process
C2U37_RS01400	COG1328	CTP reductase activity
C2U37_RS01410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U37_RS01415	COG3115	cell septum assembly
C2U37_RS01430	COG2860	membrane
C2U37_RS01440	COG3108	Peptidase M15
C2U37_RS01445	COG2989	Protein conserved in bacteria
C2U37_RS01460	COG0463	Glycosyl transferase, family 2
C2U37_RS01475	COG0366	Alpha amylase catalytic
C2U37_RS01515	COG3706	GGDEF domain
C2U37_RS01520	COG0037	tRNA processing
C2U37_RS01525	COG3590	peptidase
C2U37_RS01535	COG0488	(ABC) transporter
C2U37_RS01545	COG0531	amino acid
C2U37_RS01550	COG0814	amino acid
C2U37_RS01565	COG0825	malonyl-CoA metabolic process
C2U37_RS01575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U37_RS01580	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U37_RS01585	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U37_RS01590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U37_RS01595	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U37_RS01610	COG0750	zinc metalloprotease
C2U37_RS01615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2U37_RS01620	COG0575	Belongs to the CDS family
C2U37_RS01625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2U37_RS01630	COG0233	cytoplasmic translational termination
C2U37_RS01635	COG0528	UMP kinase activity
C2U37_RS01640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2U37_RS01645	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U37_RS01650	COG0024	Methionine aminopeptidase
C2U37_RS01655	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2U37_RS01660	COG2171	N-acyltransferase activity
C2U37_RS01670	COG1263	PTS System
C2U37_RS01670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U37_RS01695	COG0564	pseudouridine synthase activity
C2U37_RS01700	COG3098	single-species biofilm formation
C2U37_RS01725	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C2U37_RS01735	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U37_RS01735	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U37_RS01750	COG1611	Belongs to the LOG family
C2U37_RS01755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U37_RS01760	COG0473	3-isopropylmalate dehydrogenase activity
C2U37_RS01770	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C2U37_RS01785	COG0583	DNA-binding transcription factor activity
C2U37_RS01790	COG0840	transmembrane signaling receptor activity
C2U37_RS01795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U37_RS01810	COG1477	protein flavinylation
C2U37_RS01815	COG2871	sodium ion transport
C2U37_RS01820	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U37_RS01825	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U37_RS01830	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U37_RS01835	COG1805	sodium ion transport
C2U37_RS01840	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U37_RS01845	COG0271	Belongs to the BolA IbaG family
C2U37_RS01850	COG2813	Specifically methylates the guanine in position
C2U37_RS01860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U37_RS01870	COG2211	Major facilitator Superfamily
C2U37_RS01880	COG1666	GTP binding
C2U37_RS01885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2U37_RS01895	COG0659	secondary active sulfate transmembrane transporter activity
C2U37_RS01910	COG2723	6-phospho-beta-galactosidase activity
C2U37_RS01915	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2U37_RS01935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U37_RS01945	COG1151	hydroxylamine reductase activity
C2U37_RS01950	COG0783	Belongs to the Dps family
C2U37_RS01975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U37_RS01990	COG4221	oxidoreductase activity
C2U37_RS02000	COG0415	Belongs to the DNA photolyase family
C2U37_RS02005	COG0789	Transcriptional regulator
C2U37_RS02010	COG3272	Protein of unknown function (DUF1722)
C2U37_RS02035	COG1605	Chorismate mutase
C2U37_RS02035	COG0077	Prephenate dehydratase
C2U37_RS02065	COG2133	pyrroloquinoline quinone binding
C2U37_RS02075	COG1349	DNA-binding transcription factor activity
C2U37_RS02080	COG2084	Dehydrogenase
C2U37_RS02085	COG3395	kinase activity
C2U37_RS02090	COG0235	Class ii aldolase
C2U37_RS02095	COG3622	Belongs to the hyi family
C2U37_RS02100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U37_RS02105	COG2610	gluconate transmembrane transporter activity
C2U37_RS02125	COG0300	oxidoreductase activity
C2U37_RS02150	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2U37_RS02170	COG3813	Protein conserved in bacteria
C2U37_RS02180	COG0826	peptidase U32
C2U37_RS02185	COG1280	lysine exporter protein (LysE YggA)
C2U37_RS02195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U37_RS02220	COG2199	diguanylate cyclase activity
C2U37_RS02220	COG2200	EAL domain
C2U37_RS02220	COG2203	Gaf domain
C2U37_RS02265	COG1566	PFAM secretion protein HlyD family protein
C2U37_RS02275	COG0114	fumarate hydratase activity
C2U37_RS02285	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U37_RS02285	COG0506	proline dehydrogenase activity
C2U37_RS02285	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U37_RS02290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U37_RS02305	COG0737	Belongs to the 5'-nucleotidase family
C2U37_RS02325	COG2204	response regulator
C2U37_RS02330	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U37_RS02340	COG2900	Belongs to the SlyX family
C2U37_RS02345	COG1047	Peptidyl-prolyl cis-trans
C2U37_RS02350	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U37_RS02360	COG0835	chemotaxis
C2U37_RS02360	COG0784	Response regulator, receiver
C2U37_RS02365	COG0429	hydrolase of the alpha beta-hydrolase fold
C2U37_RS02370	COG3706	GGDEF domain
C2U37_RS02370	COG4251	negative regulation of phosphorylation
C2U37_RS02370	COG2203	Gaf domain
C2U37_RS02370	COG5001	Diguanylate cyclase
C2U37_RS02375	COG3089	Belongs to the UPF0270 family
C2U37_RS02380	COG3954	Phosphoribulokinase
C2U37_RS02395	COG1765	OsmC-like protein
C2U37_RS02405	COG2226	methyltransferase
C2U37_RS02415	COG2202	Pas domain
C2U37_RS02415	COG2205	protein histidine kinase activity
C2U37_RS02420	COG2814	Major facilitator Superfamily
C2U37_RS02445	COG0748	coenzyme F420 binding
C2U37_RS02450	COG3721	Heme iron utilization protein
C2U37_RS02460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U37_RS02485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U37_RS02495	COG0463	Glycosyl transferase, family 2
C2U37_RS02505	COG0741	lytic transglycosylase activity
C2U37_RS02595	COG0616	signal peptide processing
C2U37_RS02610	COG4626	Terminase
C2U37_RS02610	COG1802	Transcriptional regulator
C2U37_RS02645	COG4416	COG NOG18757 non supervised orthologous group
C2U37_RS02660	COG2135	peptidase activity
C2U37_RS02665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U37_RS02670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U37_RS02800	COG3173	Aminoglycoside phosphotransferase
C2U37_RS02835	COG0582	viral genome integration into host DNA
C2U37_RS02840	COG0488	(ABC) transporter
C2U37_RS02850	COG2252	PERMEase
C2U37_RS02855	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U37_RS02860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U37_RS02865	COG3178	'Phosphotransferase
C2U37_RS02870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2U37_RS02880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U37_RS02885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U37_RS02890	COG2967	ApaG domain
C2U37_RS02895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U37_RS02905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U37_RS02910	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U37_RS02915	COG3314	Sporulation integral membrane protein YlbJ
C2U37_RS02920	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U37_RS02925	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2U37_RS02930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2U37_RS02935	COG0142	geranyltranstransferase activity
C2U37_RS02940	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2U37_RS02945	COG0330	HflC and HflK could
C2U37_RS02950	COG0330	HflC and HflK could
C2U37_RS02955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U37_RS02960	COG1923	regulation of RNA biosynthetic process
C2U37_RS02965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2U37_RS02970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U37_RS02980	COG0802	atpase or kinase
C2U37_RS02985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U37_RS02985	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U37_RS03005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U37_RS03010	COG2011	ABC-type metal ion transport system permease component
C2U37_RS03015	COG1464	Belongs to the NlpA lipoprotein family
C2U37_RS03035	COG2205	protein histidine kinase activity
C2U37_RS03035	COG0784	Response regulator, receiver
C2U37_RS03045	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C2U37_RS03050	COG5002	protein histidine kinase activity
C2U37_RS03050	COG2198	Histidine kinase
C2U37_RS03050	COG0784	Response regulator, receiver
C2U37_RS03070	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C2U37_RS03085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2U37_RS03090	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2U37_RS03095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U37_RS03100	COG2716	regulation of RNA biosynthetic process
C2U37_RS03105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U37_RS03110	COG3013	Belongs to the UPF0304 family
C2U37_RS03120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U37_RS03125	COG0280	phosphate acetyltransferase
C2U37_RS03125	COG0857	belongs to the CobB CobQ family
C2U37_RS03130	COG0440	acetolactate synthase activity
C2U37_RS03135	COG0028	Belongs to the TPP enzyme family
C2U37_RS03150	COG0671	phosphoesterase, PA-phosphatase related
C2U37_RS03160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U37_RS03165	COG0473	3-isopropylmalate dehydrogenase activity
C2U37_RS03170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2U37_RS03175	COG0066	3-isopropylmalate dehydratase activity
C2U37_RS03190	COG4143	(ABC) transporter
C2U37_RS03195	COG1178	ABC-type Fe3 transport system permease component
C2U37_RS03200	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C2U37_RS03205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2U37_RS03280	COG3385	transposase activity
C2U37_RS03285	COG2205	protein histidine kinase activity
C2U37_RS03290	COG0745	RESPONSE REGULATOR receiver
C2U37_RS03295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_RS03300	COG1136	(ABC) transporter
C2U37_RS03300	COG0577	efflux transmembrane transporter activity
C2U37_RS03310	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C2U37_RS03345	COG2199	diguanylate cyclase activity
C2U37_RS03345	COG2203	Gaf domain
C2U37_RS03350	COG0513	Belongs to the DEAD box helicase family
C2U37_RS03360	COG1917	Cupin 2, conserved barrel domain protein
C2U37_RS03360	COG2207	Transcriptional regulator
C2U37_RS03390	COG2801	Transposase and inactivated derivatives
C2U37_RS03395	COG0154	amidase activity
C2U37_RS03400	COG2957	Belongs to the agmatine deiminase family
C2U37_RS03415	COG1902	pentaerythritol trinitrate reductase activity
C2U37_RS03420	COG0456	acetyltransferase
C2U37_RS03445	COG5002	protein histidine kinase activity
C2U37_RS03445	COG5001	Diguanylate cyclase
C2U37_RS03450	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C2U37_RS03465	COG0456	acetyltransferase
C2U37_RS03475	COG1022	Amp-dependent synthetase and ligase
C2U37_RS03500	COG1794	racemase activity, acting on amino acids and derivatives
C2U37_RS03515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U37_RS03530	COG0733	neurotransmitter:sodium symporter activity
C2U37_RS03535	COG0733	neurotransmitter:sodium symporter activity
C2U37_RS03550	COG0561	phosphatase activity
C2U37_RS03580	COG1846	Transcriptional regulator
C2U37_RS03585	COG2130	NADP-dependent
C2U37_RS03615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2U37_RS03620	COG1640	4-alpha-glucanotransferase
C2U37_RS03625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U37_RS03630	COG3385	transposase activity
C2U37_RS03640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U37_RS03645	COG0840	transmembrane signaling receptor activity
C2U37_RS03720	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2U37_RS03725	COG2885	chlorophyll binding
C2U37_RS03730	COG0823	Involved in the tonB-independent uptake of proteins
C2U37_RS03745	COG0811	peptide transport
C2U37_RS03750	COG0824	Thioesterase
C2U37_RS03755	COG3790	cyd operon protein YbgE
C2U37_RS03760	COG4890	Cyd operon protein YbgT
C2U37_RS03765	COG1294	oxidase, subunit
C2U37_RS03770	COG1271	oxidase subunit
C2U37_RS03775	COG2255	four-way junction helicase activity
C2U37_RS03780	COG0632	four-way junction helicase activity
C2U37_RS03790	COG0442	prolyl-tRNA aminoacylation
C2U37_RS03795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U37_RS03800	COG4221	oxidoreductase activity
C2U37_RS03815	COG1024	Enoyl-CoA hydratase
C2U37_RS03830	COG4166	transmembrane transport
C2U37_RS03840	COG0840	transmembrane signaling receptor activity
C2U37_RS03845	COG0513	Belongs to the DEAD box helicase family
C2U37_RS03880	COG0457	Tetratricopeptide repeat
C2U37_RS03880	COG3118	belongs to the thioredoxin family
C2U37_RS03890	COG1215	transferase activity, transferring glycosyl groups
C2U37_RS03910	COG2194	sulfuric ester hydrolase activity
C2U37_RS03915	COG1448	Aminotransferase
C2U37_RS03935	COG1328	CTP reductase activity
C2U37_RS03960	COG0840	transmembrane signaling receptor activity
C2U37_RS03965	COG3397	chitin binding
C2U37_RS03970	COG0583	DNA-binding transcription factor activity
C2U37_RS03975	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U37_RS03980	COG4208	sulfate ABC transporter
C2U37_RS03985	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U37_RS03995	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U37_RS04025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U37_RS04030	COG0564	pseudouridine synthase activity
C2U37_RS04050	COG0459	protein refolding
C2U37_RS04055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2U37_RS04060	COG0534	Mate efflux family protein
C2U37_RS04065	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2U37_RS04070	COG1027	Aspartate ammonia-lyase
C2U37_RS04075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U37_RS04080	COG2918	glutathione biosynthetic process
C2U37_RS04085	COG0612	Peptidase, M16
C2U37_RS04090	COG1238	metal cluster binding
C2U37_RS04130	COG0359	binds to the 23S rRNA
C2U37_RS04135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2U37_RS04140	COG0360	Binds together with S18 to 16S ribosomal RNA
C2U37_RS04145	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U37_RS04155	COG2153	protein acetylation
C2U37_RS04165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U37_RS04170	COG0557	exoribonuclease II activity
C2U37_RS04175	COG3706	GGDEF domain
C2U37_RS04180	COG1854	S-ribosylhomocysteine lyase activity
C2U37_RS04195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2U37_RS04195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U37_RS04235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2U37_RS04240	COG1047	Peptidyl-prolyl cis-trans
C2U37_RS04245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2U37_RS04250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U37_RS04255	COG0196	riboflavin kinase activity
C2U37_RS04260	COG0728	peptidoglycan biosynthetic process
C2U37_RS04265	COG0268	Binds directly to 16S ribosomal RNA
C2U37_RS04270	COG0640	Transcriptional regulator
C2U37_RS04275	COG0583	DNA-binding transcription factor activity
C2U37_RS04285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U37_RS04290	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2U37_RS04295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2U37_RS04305	COG1051	belongs to the nudix hydrolase family
C2U37_RS04320	COG0335	large ribosomal subunit rRNA binding
C2U37_RS04325	COG0336	Belongs to the RNA methyltransferase TrmD family
C2U37_RS04330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U37_RS04335	COG0228	four-way junction DNA binding
C2U37_RS04340	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U37_RS04345	COG4137	Cytochrome C assembly protein
C2U37_RS04350	COG4536	flavin adenine dinucleotide binding
C2U37_RS04360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U37_RS04360	COG1017	nitric oxide dioxygenase activity
C2U37_RS04365	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2U37_RS04375	COG0039	L-malate dehydrogenase activity
C2U37_RS04380	COG4160	amino acid transport
C2U37_RS04385	COG4215	(ABC) transporter
C2U37_RS04390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_RS04395	COG1126	abc transporter atp-binding protein
C2U37_RS04400	COG1438	arginine binding
C2U37_RS04405	COG2837	iron assimilation
C2U37_RS04410	COG3842	ATPase activity
C2U37_RS04425	COG0347	Belongs to the P(II) protein family
C2U37_RS04440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U37_RS04445	COG0583	DNA-binding transcription factor activity
C2U37_RS04460	COG1929	Belongs to the glycerate kinase type-1 family
C2U37_RS04465	COG2610	gluconate transmembrane transporter activity
C2U37_RS04470	COG3835	regulator
C2U37_RS04475	COG3112	Uncharacterised protein family (UPF0231)
C2U37_RS04495	COG1872	DUF167
C2U37_RS04500	COG0762	integral membrane protein
C2U37_RS04505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2U37_RS04510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U37_RS04525	COG3022	response to hydroperoxide
C2U37_RS04530	COG0513	Belongs to the DEAD box helicase family
C2U37_RS04535	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2U37_RS04555	COG0735	belongs to the Fur family
C2U37_RS04560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U37_RS04575	COG0776	regulation of translation
C2U37_RS04580	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2U37_RS04590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2U37_RS04605	COG0560	Phosphoserine phosphatase
C2U37_RS04615	COG3447	MASE1 domain protein
C2U37_RS04615	COG5001	Diguanylate cyclase
C2U37_RS04615	COG5002	protein histidine kinase activity
C2U37_RS04620	COG0813	purine-nucleoside phosphorylase activity
C2U37_RS04625	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2U37_RS04630	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2U37_RS04635	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2U37_RS04645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U37_RS04650	COG0084	hydrolase, TatD family'
C2U37_RS04665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U37_RS04670	COG0004	ammonium transporteR
C2U37_RS04690	COG0795	lipopolysaccharide-transporting ATPase activity
C2U37_RS04695	COG0795	lipopolysaccharide-transporting ATPase activity
C2U37_RS04700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U37_RS04705	COG2927	DNA polymerase III (CHI subunit)
C2U37_RS04710	COG0525	valine-tRNA ligase activity
C2U37_RS04715	COG1253	flavin adenine dinucleotide binding
C2U37_RS04720	COG0586	Pfam SNARE associated Golgi protein
C2U37_RS04725	COG1686	Belongs to the peptidase S11 family
C2U37_RS04760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2U37_RS04765	COG0527	aspartate kinase activity
C2U37_RS04770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U37_RS04775	COG2137	regulation of response to DNA damage stimulus
C2U37_RS04780	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2U37_RS04785	COG1546	Belongs to the CinA family
C2U37_RS04795	COG4584	PFAM Integrase catalytic
C2U37_RS04800	COG1484	DNA-dependent DNA replication
C2U37_RS04825	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U37_RS04850	COG0732	type I restriction modification DNA specificity domain
C2U37_RS04855	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2U37_RS04890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2U37_RS04920	COG0739	heme binding
C2U37_RS04940	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2U37_RS04945	COG1121	(ABC) transporter
C2U37_RS04950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U37_RS04955	COG0583	DNA-binding transcription factor activity
C2U37_RS04965	COG1573	uracil-dna glycosylase
C2U37_RS04970	COG2962	Rard protein
C2U37_RS04975	COG2827	Endonuclease containing a URI domain
C2U37_RS04990	COG1842	Phage shock protein A
C2U37_RS04995	COG0204	Acyl-transferase
C2U37_RS05015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U37_RS05025	COG0484	heat shock protein binding
C2U37_RS05070	COG3039	Transposase
C2U37_RS05090	COG1289	transmembrane transporter activity
C2U37_RS05095	COG1566	PFAM secretion protein HlyD family protein
C2U37_RS05110	COG1051	belongs to the nudix hydrolase family
C2U37_RS05115	COG3150	esterase
C2U37_RS05130	COG3151	Protein conserved in bacteria
C2U37_RS05135	COG0494	nUDIX hydrolase
C2U37_RS05140	COG1538	Outer membrane efflux protein
C2U37_RS05145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2U37_RS05145	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2U37_RS05150	COG1560	Kdo2-lipid A biosynthetic process
C2U37_RS05165	COG2771	luxR family
C2U37_RS05170	COG3916	Acyl-homoserine-lactone synthase
C2U37_RS05180	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C2U37_RS05185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_RS05185	COG2213	PTS system mannitol-specific
C2U37_RS05190	COG0246	Mannitol dehydrogenase
C2U37_RS05195	COG3722	fumarate hydratase activity
C2U37_RS05220	COG1671	Belongs to the UPF0178 family
C2U37_RS05235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U37_RS05240	COG0513	Belongs to the DEAD box helicase family
C2U37_RS05260	COG1575	Belongs to the MenA family. Type 1 subfamily
C2U37_RS05265	COG1169	isochorismate synthase
C2U37_RS05270	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2U37_RS05275	COG0596	Alpha beta hydrolase
C2U37_RS05280	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2U37_RS05290	COG0318	PFAM AMP-dependent synthetase and ligase
C2U37_RS05295	COG3291	Pkd domain containing protein
C2U37_RS05300	COG2949	membrane
C2U37_RS05305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2U37_RS05315	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2U37_RS05345	COG2873	o-acetylhomoserine
C2U37_RS05355	COG1979	alcohol dehydrogenase
C2U37_RS05370	COG4221	oxidoreductase activity
C2U37_RS05390	COG1285	pathogenesis
C2U37_RS05405	COG1368	sulfuric ester hydrolase activity
C2U37_RS05410	COG1522	sequence-specific DNA binding
C2U37_RS05420	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2U37_RS05430	COG1058	Belongs to the CinA family
C2U37_RS05430	COG1546	Belongs to the CinA family
C2U37_RS05435	COG1988	membrane-bound metal-dependent
C2U37_RS05445	COG0561	phosphatase activity
C2U37_RS05450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2U37_RS05460	COG1011	Hydrolase
C2U37_RS05475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2U37_RS05480	COG0019	diaminopimelate decarboxylase activity
C2U37_RS05490	COG1965	Belongs to the frataxin family
C2U37_RS05495	COG0400	carboxylic ester hydrolase activity
C2U37_RS05500	COG3072	Adenylate cyclase
C2U37_RS05510	COG0181	hydroxymethylbilane synthase activity
C2U37_RS05520	COG2959	enzyme of heme biosynthesis
C2U37_RS05525	COG3071	HemY protein
C2U37_RS05535	COG1494	fructose-1,6-bisphosphatase
C2U37_RS05545	COG2226	methyltransferase
C2U37_RS05570	COG1733	regulation of RNA biosynthetic process
C2U37_RS05585	COG3932	Exopolysaccharide synthesis, ExoD
C2U37_RS05620	COG3039	Transposase
C2U37_RS05630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U37_RS05635	COG2022	thiamine diphosphate biosynthetic process
C2U37_RS05645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U37_RS05650	COG0352	thiamine-phosphate diphosphorylase activity
C2U37_RS05655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2U37_RS05670	COG0745	RESPONSE REGULATOR receiver
C2U37_RS05675	COG0642	Histidine kinase
C2U37_RS05680	COG0189	ligase activity
C2U37_RS05715	COG2321	neutral zinc metallopeptidase
C2U37_RS05725	COG0477	Major facilitator Superfamily
C2U37_RS05740	COG0312	modulator of DNA gyrase
C2U37_RS05745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U37_RS05750	COG3164	Protein of unknown function
C2U37_RS05755	COG1530	ribonuclease E activity
C2U37_RS05760	COG0424	maF-like protein
C2U37_RS05765	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U37_RS05770	COG1792	Involved in formation and maintenance of cell shape
C2U37_RS05775	COG1077	Cell shape determining protein MreB Mrl
C2U37_RS05820	COG1459	type II secretion system
C2U37_RS05825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U37_RS05885	COG0387	Pfam Sodium calcium exchanger
C2U37_RS05890	COG2986	histidine ammonia-lyase
C2U37_RS05895	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2U37_RS05900	COG0010	Belongs to the arginase family
C2U37_RS05905	COG1228	amidohydrolase
C2U37_RS05910	COG2188	Transcriptional regulator
C2U37_RS05915	COG0288	reversible hydration of carbon dioxide
C2U37_RS05925	COG2177	Part of the ABC transporter FtsEX involved in
C2U37_RS05930	COG2884	Cell division ATP-binding protein ftsE
C2U37_RS05935	COG0552	protein localization to endoplasmic reticulum
C2U37_RS05940	COG0742	ribosomal rna small subunit methyltransferase
C2U37_RS05965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U37_RS05970	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U37_RS05980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U37_RS05990	COG2095	MarC family integral membrane protein
C2U37_RS06000	COG1301	dicarboxylic acid transport
C2U37_RS06010	COG0583	DNA-binding transcription factor activity
C2U37_RS06025	COG3714	YhhN family
C2U37_RS06040	COG2358	TRAP transporter, solute receptor (TAXI family
C2U37_RS06045	COG1770	oligopeptidase
C2U37_RS06060	COG4221	oxidoreductase activity
C2U37_RS06070	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U37_RS06130	COG0203	ribosomal protein L17
C2U37_RS06135	COG0202	RNA polymerase activity
C2U37_RS06140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2U37_RS06145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2U37_RS06150	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2U37_RS06155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U37_RS06160	COG0201	protein transport
C2U37_RS06165	COG0200	Binds to the 23S rRNA
C2U37_RS06170	COG1841	ribosomal large subunit assembly
C2U37_RS06175	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2U37_RS06180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2U37_RS06185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2U37_RS06190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2U37_RS06195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2U37_RS06200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2U37_RS06205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2U37_RS06210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2U37_RS06215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2U37_RS06220	COG0255	Belongs to the universal ribosomal protein uL29 family
C2U37_RS06225	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2U37_RS06230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2U37_RS06235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2U37_RS06240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2U37_RS06245	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2U37_RS06250	COG0089	rRNA binding
C2U37_RS06255	COG0088	Forms part of the polypeptide exit tunnel
C2U37_RS06260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U37_RS06265	COG0051	transcription antitermination factor activity, RNA binding
C2U37_RS06275	COG2205	protein histidine kinase activity
C2U37_RS06285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U37_RS06290	COG2183	response to ionizing radiation
C2U37_RS06305	COG0596	Alpha beta hydrolase
C2U37_RS06310	COG1040	competence protein
C2U37_RS06315	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2U37_RS06315	COG0316	Belongs to the HesB IscA family
C2U37_RS06320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2U37_RS06325	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2U37_RS06330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U37_RS06335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2U37_RS06340	COG4942	peptidase
C2U37_RS06350	COG1609	Transcriptional regulator
C2U37_RS06365	COG0800	Aldolase
C2U37_RS06370	COG0129	dihydroxy-acid dehydratase activity
C2U37_RS06375	COG3265	gluconokinase activity
C2U37_RS06380	COG2610	gluconate transmembrane transporter activity
C2U37_RS06385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U37_RS06390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U37_RS06400	COG0456	acetyltransferase
C2U37_RS06410	COG1490	D-aminoacyl-tRNA deacylase activity
C2U37_RS06415	COG1295	ribonuclease BN
C2U37_RS06420	COG1217	gtp-binding protein TYPA
C2U37_RS06425	COG0174	glutamine synthetase
C2U37_RS06435	COG3852	Histidine kinase
C2U37_RS06445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U37_RS06450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U37_RS06460	COG3078	GTPase activator activity
C2U37_RS06470	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2U37_RS06480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U37_RS06485	COG0408	coproporphyrinogen oxidase activity
C2U37_RS06490	COG0009	L-threonylcarbamoyladenylate synthase
C2U37_RS06495	COG0551	DNA topoisomerase type I activity
C2U37_RS06500	COG2922	Belongs to the Smg family
C2U37_RS06505	COG0758	DNA mediated transformation
C2U37_RS06515	COG0242	peptide deformylase activity
C2U37_RS06520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2U37_RS06525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U37_RS06525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U37_RS06530	COG0569	domain protein
C2U37_RS06535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U37_RS06540	COG1322	Protein conserved in bacteria
C2U37_RS06570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U37_RS06580	COG0519	Catalyzes the synthesis of GMP from XMP
C2U37_RS06580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U37_RS06590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2U37_RS06595	COG1396	sequence-specific DNA binding
C2U37_RS06600	COG1012	belongs to the aldehyde dehydrogenase family
C2U37_RS06605	COG2962	Rard protein
C2U37_RS06615	COG1280	lysine exporter protein (LysE YggA)
C2U37_RS06655	COG0583	DNA-binding transcription factor activity
C2U37_RS06660	COG1943	Transposase
C2U37_RS06665	COG0210	DNA helicase
C2U37_RS06670	COG1744	ABC transporter substrate-binding protein PnrA-like
C2U37_RS06675	COG3845	ABC transporter
C2U37_RS06680	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2U37_RS06685	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2U37_RS06695	COG0583	DNA-binding transcription factor activity
C2U37_RS06720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U37_RS06725	COG0385	Bile acid
C2U37_RS06730	COG0531	amino acid
C2U37_RS06735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U37_RS06740	COG0531	amino acid
C2U37_RS06745	COG2731	YhcH YjgK YiaL family protein
C2U37_RS06750	COG3250	beta-galactosidase activity
C2U37_RS06755	COG1609	Transcriptional regulator
C2U37_RS06795	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U37_RS06800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U37_RS06800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U37_RS06805	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2U37_RS06810	COG3074	FtsZ-dependent cytokinesis
C2U37_RS06820	COG1045	serine acetyltransferase
C2U37_RS06830	COG0745	RESPONSE REGULATOR receiver
C2U37_RS06835	COG2205	protein histidine kinase activity
C2U37_RS06840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U37_RS06845	COG0534	Mate efflux family protein
C2U37_RS06860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U37_RS06865	COG2937	Belongs to the GPAT DAPAT family
C2U37_RS06870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2U37_RS06875	COG3161	chorismate lyase activity
C2U37_RS06880	COG1580	Controls the rotational direction of flagella during chemotaxis
C2U37_RS06900	COG1609	Transcriptional regulator
C2U37_RS06925	COG0859	PFAM glycosyl transferase family 9
C2U37_RS06930	COG3306	glycosyltransferase involved in LPS biosynthesis
C2U37_RS06945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U37_RS06955	COG0156	8-amino-7-oxononanoate synthase activity
C2U37_RS06960	COG1063	alcohol dehydrogenase
C2U37_RS06980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U37_RS06985	COG2166	iron-sulfur cluster assembly
C2U37_RS06990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U37_RS07040	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2U37_RS07045	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U37_RS07050	COG2223	nitrite transmembrane transporter activity
C2U37_RS07055	COG3279	Response regulator of the LytR AlgR family
C2U37_RS07060	COG3275	phosphorelay sensor kinase activity
C2U37_RS07080	COG3039	Transposase
C2U37_RS07100	COG1280	lysine exporter protein (LysE YggA)
C2U37_RS07105	COG2223	nitrite transmembrane transporter activity
C2U37_RS07110	COG2081	HI0933 family
C2U37_RS07115	COG1528	Iron-storage protein
C2U37_RS07120	COG3706	GGDEF domain
C2U37_RS07125	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U37_RS07135	COG0589	response to stress
C2U37_RS07175	COG3642	lipopolysaccharide core region biosynthetic process
C2U37_RS07180	COG0859	PFAM glycosyl transferase family 9
C2U37_RS07200	COG1758	RNA polymerase activity
C2U37_RS07205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U37_RS07210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U37_RS07215	COG2267	carboxylic ester hydrolase activity
C2U37_RS07220	COG0561	phosphatase activity
C2U37_RS07250	COG1309	transcriptional regulator
C2U37_RS07255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_RS07260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_RS07265	COG4191	Histidine kinase
C2U37_RS07265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_RS07270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U37_RS07295	COG2205	protein histidine kinase activity
C2U37_RS07300	COG0745	RESPONSE REGULATOR receiver
C2U37_RS07305	COG2814	Major facilitator Superfamily
C2U37_RS07320	COG3977	Valine--pyruvate aminotransferase
C2U37_RS07325	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U37_RS07330	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U37_RS07335	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U37_RS07340	COG2207	Transcriptional regulator
C2U37_RS07345	COG0187	DNA topoisomerase II activity
C2U37_RS07355	COG0592	DNA-directed DNA polymerase activity
C2U37_RS07360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2U37_RS07375	COG1126	abc transporter atp-binding protein
C2U37_RS07380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2U37_RS07385	COG0594	ribonuclease P activity
C2U37_RS07390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2U37_RS07395	COG0706	membrane insertase activity
C2U37_RS07400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2U37_RS07410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U37_RS07415	COG1120	ATPase activity
C2U37_RS07420	COG4615	Cyclic peptide transporter
C2U37_RS07425	COG4774	siderophore transport
C2U37_RS07430	COG0716	FMN binding
C2U37_RS07435	COG0445	tRNA wobble uridine modification
C2U37_RS07440	COG0357	Ribosomal RNA small subunit methyltransferase G
C2U37_RS07445	COG1192	Involved in chromosome partitioning
C2U37_RS07450	COG1475	DNA binding
C2U37_RS07460	COG0356	it plays a direct role in the translocation of protons across the membrane
C2U37_RS07470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2U37_RS07475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2U37_RS07480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U37_RS07485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2U37_RS07490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2U37_RS07495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2U37_RS07500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2U37_RS07505	COG4452	Inner membrane protein CreD
C2U37_RS07515	COG2205	protein histidine kinase activity
C2U37_RS07520	COG0745	RESPONSE REGULATOR receiver
C2U37_RS07525	COG1349	DNA-binding transcription factor activity
C2U37_RS07530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U37_RS07605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U37_RS07610	COG0166	Belongs to the GPI family
C2U37_RS07640	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_RS07650	COG1349	DNA-binding transcription factor activity
C2U37_RS07665	COG2771	luxR family
C2U37_RS07675	COG0811	peptide transport
C2U37_RS07680	COG0811	peptide transport
C2U37_RS07685	COG0848	biopolymer transport protein
C2U37_RS07690	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2U37_RS07725	COG0402	S-adenosylhomocysteine deaminase activity
C2U37_RS07730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2U37_RS07740	COG3165	ubiquinone biosynthetic process from chorismate
C2U37_RS07745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U37_RS07750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U37_RS07755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U37_RS07760	COG0805	protein transport
C2U37_RS07765	COG0084	hydrolase, TatD family'
C2U37_RS07785	COG0742	ribosomal rna small subunit methyltransferase
C2U37_RS07795	COG0248	Ppx GppA phosphatase
C2U37_RS07800	COG0513	Belongs to the DEAD box helicase family
C2U37_RS07805	COG3118	belongs to the thioredoxin family
C2U37_RS07820	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U37_RS07830	COG2960	long-chain fatty acid transporting porin activity
C2U37_RS07845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U37_RS07885	COG1609	Transcriptional regulator
C2U37_RS07890	COG3604	Transcriptional regulator
C2U37_RS07895	COG1773	rubredoxin
C2U37_RS07895	COG0426	domain, Protein
C2U37_RS07900	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U37_RS07910	COG0348	domain, Protein
C2U37_RS07920	COG3033	Beta-eliminating lyase
C2U37_RS07925	COG0814	amino acid
C2U37_RS07930	COG0814	amino acid
C2U37_RS07950	COG2203	Gaf domain
C2U37_RS07950	COG3706	GGDEF domain
C2U37_RS07950	COG4251	negative regulation of phosphorylation
C2U37_RS07950	COG5001	Diguanylate cyclase
C2U37_RS07955	COG3039	Transposase
C2U37_RS07960	COG0751	glycine-tRNA ligase activity
C2U37_RS07965	COG0752	glycyl-tRNA synthetase alpha subunit
C2U37_RS07970	COG2818	Glycosylase
C2U37_RS07975	COG1335	isochorismatase
C2U37_RS07985	COG2885	chlorophyll binding
C2U37_RS08010	COG0251	oxidation-reduction process
C2U37_RS08015	COG0425	Belongs to the sulfur carrier protein TusA family
C2U37_RS08040	COG0183	Belongs to the thiolase family
C2U37_RS08045	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U37_RS08045	COG1024	Enoyl-CoA hydratase
C2U37_RS08050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U37_RS08055	COG0006	proline dipeptidase activity
C2U37_RS08060	COG1739	Uncharacterized protein family UPF0029
C2U37_RS08065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U37_RS08070	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2U37_RS08095	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U37_RS08095	COG1042	CoA-binding domain protein
C2U37_RS08095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U37_RS08105	COG0583	DNA-binding transcription factor activity
C2U37_RS08110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U37_RS08115	COG0166	Belongs to the GPI family
C2U37_RS08125	COG0668	transmembrane transport
C2U37_RS08135	COG1309	transcriptional regulator
C2U37_RS08140	COG0756	dUTP diphosphatase activity
C2U37_RS08145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U37_RS08150	COG2003	Belongs to the UPF0758 family
C2U37_RS08155	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2U37_RS08160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2U37_RS08170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2U37_RS08175	COG2990	Protein conserved in bacteria
C2U37_RS08180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2U37_RS08185	COG0859	PFAM glycosyl transferase family 9
C2U37_RS08190	COG0463	Glycosyl transferase, family 2
C2U37_RS08195	COG0859	PFAM glycosyl transferase family 9
C2U37_RS08200	COG1519	Transferase
C2U37_RS08210	COG1561	YicC-like family, N-terminal region
C2U37_RS08215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2U37_RS08220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2U37_RS08235	COG2203	Gaf domain
C2U37_RS08235	COG3706	GGDEF domain
C2U37_RS08235	COG4251	negative regulation of phosphorylation
C2U37_RS08235	COG5001	Diguanylate cyclase
C2U37_RS08240	COG3084	Protein conserved in bacteria
C2U37_RS08250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U37_RS08255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U37_RS08260	COG3639	organic phosphonate transmembrane transporter activity
C2U37_RS08265	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2U37_RS08270	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2U37_RS08280	COG1335	isochorismatase
C2U37_RS08290	COG1683	Conserved Protein
C2U37_RS08295	COG0204	Acyl-transferase
C2U37_RS08300	COG0204	Acyl-transferase
C2U37_RS08305	COG0606	chelatase, subunit chli
C2U37_RS08320	COG3978	acetolactate synthase activity
C2U37_RS08330	COG0129	dihydroxy-acid dehydratase activity
C2U37_RS08350	COG1309	transcriptional regulator
C2U37_RS08355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U37_RS08360	COG0254	rRNA binding
C2U37_RS08365	COG0702	epimerase
C2U37_RS08370	COG0281	malic enzyme
C2U37_RS08380	COG2205	protein histidine kinase activity
C2U37_RS08390	COG0745	RESPONSE REGULATOR receiver
C2U37_RS08395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U37_RS08410	COG0366	Alpha amylase catalytic
C2U37_RS08425	COG0443	Heat shock 70 kDa protein
C2U37_RS08430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U37_RS08435	COG3045	CreA protein
C2U37_RS08455	COG0174	glutamine synthetase
C2U37_RS08475	COG3842	ATPase activity
C2U37_RS08480	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U37_RS08485	COG1177	transmembrane transport
C2U37_RS08490	COG2258	MOSC domain
C2U37_RS08505	COG2050	protein possibly involved in aromatic compounds catabolism
C2U37_RS08510	COG0514	ATP-dependent DNA helicase (RecQ)
C2U37_RS08520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U37_RS08530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2U37_RS08535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U37_RS08540	COG2239	Acts as a magnesium transporter
C2U37_RS08545	COG1648	precorrin-2 dehydrogenase activity
C2U37_RS08545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U37_RS08550	COG2116	formate transmembrane transporter activity
C2U37_RS08560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U37_RS08565	COG0842	Transport permease protein
C2U37_RS08570	COG0842	Transport permease protein
C2U37_RS08575	COG1131	(ABC) transporter
C2U37_RS08580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_RS08595	COG0477	Major facilitator Superfamily
C2U37_RS08600	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2U37_RS08605	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2U37_RS08630	COG1595	DNA-templated transcription, initiation
C2U37_RS08635	COG3806	Anti-sigma factor
C2U37_RS08640	COG1968	undecaprenyl-diphosphatase activity
C2U37_RS08645	COG0667	Aldo Keto reductase
C2U37_RS08650	COG2017	converts alpha-aldose to the beta-anomer
C2U37_RS08655	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2U37_RS08665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U37_RS08670	COG1609	Transcriptional regulator
C2U37_RS08675	COG3250	beta-galactosidase activity
C2U37_RS08715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U37_RS08720	COG1288	antiporter activity
C2U37_RS08725	COG1438	arginine binding
C2U37_RS08730	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C2U37_RS08735	COG0540	Belongs to the ATCase OTCase family
C2U37_RS08760	COG0840	transmembrane signaling receptor activity
C2U37_RS08770	COG3040	lipid binding
C2U37_RS08775	COG2207	Transcriptional regulator
C2U37_RS08780	COG1979	alcohol dehydrogenase
C2U37_RS08785	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U37_RS08790	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2U37_RS08795	COG3385	transposase activity
C2U37_RS08800	COG2964	Protein conserved in bacteria
C2U37_RS08805	COG3681	Belongs to the UPF0597 family
C2U37_RS08810	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U37_RS08815	COG0564	pseudouridine synthase activity
C2U37_RS08825	COG0542	response to heat
C2U37_RS08830	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U37_RS08835	COG2502	aspartate--ammonia ligase
C2U37_RS08840	COG1522	sequence-specific DNA binding
C2U37_RS08850	COG0516	GMP reductase activity
C2U37_RS08850	COG0517	IMP dehydrogenase activity
C2U37_RS08870	COG2205	protein histidine kinase activity
C2U37_RS08880	COG2204	response regulator
C2U37_RS08900	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U37_RS08935	COG0243	molybdopterin cofactor binding
C2U37_RS08940	COG3005	denitrification pathway
C2U37_RS08945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U37_RS08950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U37_RS08955	COG0569	domain protein
C2U37_RS08960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2U37_RS08985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U37_RS09000	COG0250	Participates in transcription elongation, termination and antitermination
C2U37_RS09005	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2U37_RS09010	COG0081	regulation of translation
C2U37_RS09015	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2U37_RS09020	COG0222	ribosome binding
C2U37_RS09025	COG0085	RNA polymerase activity
C2U37_RS09030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2U37_RS09035	COG2964	Protein conserved in bacteria
C2U37_RS09040	COG0251	oxidation-reduction process
C2U37_RS09045	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U37_RS09055	COG2168	tRNA wobble position uridine thiolation
C2U37_RS09060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U37_RS09065	COG0049	tRNA binding
C2U37_RS09070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U37_RS09075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U37_RS09080	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U37_RS09110	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2U37_RS09115	COG2252	PERMEase
C2U37_RS09120	COG2376	Dihydroxyacetone kinase
C2U37_RS09125	COG1461	Dihydroxyacetone kinase
C2U37_RS09155	COG0628	permease
C2U37_RS09160	COG0494	nUDIX hydrolase
C2U37_RS09180	COG0753	catalase activity
C2U37_RS09185	COG0456	acetyltransferase
C2U37_RS09215	COG3842	ATPase activity
C2U37_RS09225	COG1175	transmembrane transport
C2U37_RS09250	COG0583	DNA-binding transcription factor activity
C2U37_RS09260	COG1741	Belongs to the pirin family
C2U37_RS09265	COG2259	Doxx family
C2U37_RS09270	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U37_RS09275	COG1074	ATP-dependent DNA helicase activity
C2U37_RS09280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U37_RS09290	COG3039	Transposase
C2U37_RS09295	COG0004	ammonium transporteR
C2U37_RS09300	COG0347	Belongs to the P(II) protein family
C2U37_RS09305	COG3706	GGDEF domain
C2U37_RS09335	COG1278	Cold shock
C2U37_RS09340	COG2801	Transposase and inactivated derivatives
C2U37_RS09365	COG2197	response regulator
C2U37_RS09370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2U37_RS09415	COG3135	benzoate transporter
C2U37_RS09420	COG1396	sequence-specific DNA binding
C2U37_RS09450	COG2926	Belongs to the UPF0265 family
C2U37_RS09460	COG3028	Belongs to the UPF0307 family
C2U37_RS09465	COG0312	modulator of DNA gyrase
C2U37_RS09470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U37_RS09475	COG5007	Belongs to the BolA IbaG family
C2U37_RS09485	COG2854	intermembrane phospholipid transfer
C2U37_RS09490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U37_RS09495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U37_RS09500	COG1127	ABC transporter
C2U37_RS09505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U37_RS09505	COG0517	IMP dehydrogenase activity
C2U37_RS09510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U37_RS09520	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U37_RS09525	COG1137	ATPase activity
C2U37_RS09530	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2U37_RS09540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_RS09545	COG1660	Displays ATPase and GTPase activities
C2U37_RS09550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_RS09570	COG3964	amidohydrolase
C2U37_RS09600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U37_RS09605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U37_RS09615	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U37_RS09620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U37_RS09625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U37_RS09630	COG0723	plastoquinol--plastocyanin reductase activity
C2U37_RS09635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2U37_RS09640	COG2857	Cytochrome c1
C2U37_RS09645	COG0625	glutathione transferase activity
C2U37_RS09650	COG2969	positive regulation of protein catabolic process
C2U37_RS09655	COG2823	Periplasmic or secreted lipoprotein
C2U37_RS09660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U37_RS09665	COG0792	nuclease activity
C2U37_RS09670	COG3107	peptidoglycan biosynthetic process
C2U37_RS09675	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2U37_RS09700	COG1987	bacterial-type flagellum assembly
C2U37_RS09725	COG1677	Flagellar hook-basal body complex protein FliE
C2U37_RS09735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U37_RS09765	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2U37_RS09770	COG1815	bacterial-type flagellum-dependent cell motility
C2U37_RS09785	COG1749	Flagellar hook protein flgE
C2U37_RS09795	COG4786	Flagellar basal body rod
C2U37_RS09800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U37_RS09805	COG1706	bacterial-type flagellum-dependent cell motility
C2U37_RS09815	COG4786	Flagellar basal body rod
C2U37_RS09815	COG1256	bacterial-type flagellum assembly
C2U37_RS09820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U37_RS09840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U37_RS09845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U37_RS09850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2U37_RS09875	COG1191	sigma factor activity
C2U37_RS09880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U37_RS09885	COG1360	Flagellar Motor Protein
C2U37_RS09895	COG1388	LysM domain
C2U37_RS09895	COG0741	lytic transglycosylase activity
C2U37_RS09905	COG2001	Belongs to the MraZ family
C2U37_RS09910	COG0275	rRNA processing
C2U37_RS09915	COG3116	cell division
C2U37_RS09920	COG0768	penicillin binding
C2U37_RS09925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U37_RS09930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U37_RS09935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U37_RS09940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2U37_RS09945	COG0772	Belongs to the SEDS family
C2U37_RS09950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U37_RS09955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U37_RS09960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U37_RS09965	COG0849	cell division
C2U37_RS09970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U37_RS09975	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2U37_RS09985	COG0653	protein targeting
C2U37_RS09995	COG0494	nUDIX hydrolase
C2U37_RS10000	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2U37_RS10005	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2U37_RS10015	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2U37_RS10020	COG1459	type II secretion system
C2U37_RS10025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U37_RS10050	COG2186	Transcriptional regulator
C2U37_RS10055	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U37_RS10060	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U37_RS10065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U37_RS10075	COG0840	transmembrane signaling receptor activity
C2U37_RS10080	COG0840	transmembrane signaling receptor activity
C2U37_RS10090	COG1049	propionate catabolic process, 2-methylcitrate cycle
C2U37_RS10095	COG2200	EAL domain
C2U37_RS10105	COG1280	lysine exporter protein (LysE YggA)
C2U37_RS10115	COG0523	cobalamin synthesis protein
C2U37_RS10120	COG0477	Major facilitator Superfamily
C2U37_RS10135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U37_RS10140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2U37_RS10190	COG1522	sequence-specific DNA binding
C2U37_RS10195	COG0110	maltose O-acetyltransferase activity
C2U37_RS10200	COG0366	Alpha amylase catalytic
C2U37_RS10205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U37_RS10205	COG1263	PTS System
C2U37_RS10225	COG0252	asparaginase activity
C2U37_RS10240	COG1803	Methylglyoxal synthase
C2U37_RS10260	COG1444	tRNA N-acetyltransferase activity
C2U37_RS10265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U37_RS10275	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C2U37_RS10305	COG0109	protoheme IX farnesyltransferase activity
C2U37_RS10310	COG1012	belongs to the aldehyde dehydrogenase family
C2U37_RS10315	COG1177	transmembrane transport
C2U37_RS10320	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U37_RS10325	COG3842	ATPase activity
C2U37_RS10330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2U37_RS10335	COG0583	DNA-binding transcription factor activity
C2U37_RS10340	COG1757	Na H antiporter
C2U37_RS10380	COG0297	glycogen (starch) synthase activity
C2U37_RS10385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2U37_RS10390	COG2813	Specifically methylates the guanine in position
C2U37_RS10395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U37_RS10400	COG4251	negative regulation of phosphorylation
C2U37_RS10400	COG5001	Diguanylate cyclase
C2U37_RS10400	COG2203	Gaf domain
C2U37_RS10400	COG3706	GGDEF domain
C2U37_RS10405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U37_RS10415	COG2995	paraquat-inducible protein a
C2U37_RS10420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U37_RS10420	COG3008	intermembrane lipid transfer
C2U37_RS10425	COG3009	Protein conserved in bacteria
C2U37_RS10435	COG3240	lipase activity
C2U37_RS10450	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2U37_RS10455	COG1194	a g-specific adenine glycosylase
C2U37_RS10465	COG3409	Peptidoglycan-binding domain 1 protein
C2U37_RS10465	COG3267	Type II secretory pathway component ExeA
C2U37_RS10470	COG0617	tRNA 3'-terminal CCA addition
C2U37_RS10475	COG0306	phosphate transporter
C2U37_RS10480	COG1392	Phosphate transport regulator
C2U37_RS10485	COG3025	triphosphatase activity
C2U37_RS10490	COG3133	Outer membrane lipoprotein
C2U37_RS10495	COG0456	acetyltransferase
C2U37_RS10510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2U37_RS10515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U37_RS10525	COG3031	protein transport across the cell outer membrane
C2U37_RS10535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U37_RS10540	COG1459	type II secretion system
C2U37_RS10545	COG2165	general secretion pathway protein
C2U37_RS10555	COG2165	general secretion pathway protein
C2U37_RS10560	COG4795	General secretion pathway protein
C2U37_RS10570	COG3156	type II secretion system protein K
C2U37_RS10580	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C2U37_RS10595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U37_RS10610	COG1011	Hydrolase
C2U37_RS10615	COG0494	nUDIX hydrolase
C2U37_RS10620	COG1218	3'(2'),5'-bisphosphate nucleotidase
C2U37_RS10625	COG0814	amino acid
C2U37_RS10630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U37_RS10645	COG0626	cystathionine gamma-synthase activity
C2U37_RS10650	COG0527	aspartate kinase activity
C2U37_RS10650	COG0460	homoserine dehydrogenase
C2U37_RS10655	COG1346	cytolysis
C2U37_RS10660	COG1380	Effector of murein hydrolase LrgA
C2U37_RS10665	COG0583	DNA-binding transcription factor activity
C2U37_RS10700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U37_RS10710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2U37_RS10720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U37_RS10725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U37_RS10735	COG0137	argininosuccinate synthase activity
C2U37_RS10740	COG0165	Argininosuccinate lyase
C2U37_RS10745	COG0583	DNA-binding transcription factor activity
C2U37_RS10755	COG1942	4-Oxalocrotonate Tautomerase
C2U37_RS10785	COG0110	maltose O-acetyltransferase activity
C2U37_RS10790	COG3174	membrane
C2U37_RS10795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_RS10800	COG1126	abc transporter atp-binding protein
C2U37_RS10805	COG0765	amino acid transport
C2U37_RS10810	COG0765	amino acid transport
C2U37_RS10815	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U37_RS10820	COG1505	serine-type exopeptidase activity
C2U37_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_RS10835	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U37_RS10850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U37_RS10855	COG4991	sh3 domain protein
C2U37_RS10865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2U37_RS10870	COG1940	carbohydrate kinase activity
C2U37_RS10875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U37_RS10880	COG0126	phosphoglycerate kinase activity
C2U37_RS10890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U37_RS10925	COG0583	DNA-binding transcription factor activity
C2U37_RS10935	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U37_RS10945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U37_RS10950	COG1595	DNA-templated transcription, initiation
C2U37_RS10955	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2U37_RS10970	COG0481	GTPase activity
C2U37_RS10975	COG0681	Belongs to the peptidase S26 family
C2U37_RS10980	COG0571	ribonuclease III activity
C2U37_RS10990	COG1381	Involved in DNA repair and RecF pathway recombination
C2U37_RS10995	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U37_RS11000	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U37_RS11005	COG4807	Protein conserved in bacteria
C2U37_RS11015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U37_RS11020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U37_RS11025	COG3956	TIGRFAM MazG family protein
C2U37_RS11030	COG0504	CTP synthase activity
C2U37_RS11035	COG0148	phosphopyruvate hydratase activity
C2U37_RS11040	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2U37_RS11045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2U37_RS11055	COG0585	pseudouridine synthase activity
C2U37_RS11060	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U37_RS11065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U37_RS11070	COG1238	metal cluster binding
C2U37_RS11075	COG1388	LysM domain
C2U37_RS11075	COG4942	peptidase
C2U37_RS11085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2U37_RS11090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U37_RS11095	COG1610	YqeY-like protein
C2U37_RS11100	COG0358	DNA primase activity
C2U37_RS11105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2U37_RS11125	COG3039	Transposase
C2U37_RS11135	COG0529	Catalyzes the synthesis of activated sulfate
C2U37_RS11140	COG3273	potassium ion transport
C2U37_RS11140	COG0471	metal ion transport
C2U37_RS11145	COG2895	sulfate adenylyltransferase (ATP) activity
C2U37_RS11150	COG0175	sulfate reduction
C2U37_RS11155	COG1648	precorrin-2 dehydrogenase activity
C2U37_RS11155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U37_RS11160	COG0330	HflC and HflK could
C2U37_RS11165	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U37_RS11175	COG0673	inositol 2-dehydrogenase activity
C2U37_RS11185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2U37_RS11190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U37_RS11195	COG3036	rescue of stalled ribosome
C2U37_RS11210	COG0138	bifunctional purine biosynthesis protein purh
C2U37_RS11280	COG1136	(ABC) transporter
C2U37_RS11295	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2U37_RS11310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U37_RS11315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U37_RS11320	COG0163	prenyltransferase activity
C2U37_RS11335	COG1131	(ABC) transporter
C2U37_RS11340	COG0842	Transport permease protein
C2U37_RS11350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2U37_RS11355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2U37_RS11360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2U37_RS11370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U37_RS11375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U37_RS11380	COG1489	DNA binding
C2U37_RS11390	COG1643	Atp-dependent helicase
C2U37_RS11395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U37_RS11400	COG0346	lactoylglutathione lyase activity
C2U37_RS11410	COG2076	Multidrug Resistance protein
C2U37_RS11415	COG0583	DNA-binding transcription factor activity
C2U37_RS11425	COG0671	phosphoesterase, PA-phosphatase related
C2U37_RS11440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U37_RS11445	COG0038	chloride channel
C2U37_RS11455	COG0316	Belongs to the HesB IscA family
C2U37_RS11480	COG1280	lysine exporter protein (LysE YggA)
C2U37_RS11485	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2U37_RS11500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_RS11530	COG0745	RESPONSE REGULATOR receiver
C2U37_RS11535	COG3104	oligopeptide transport
C2U37_RS11540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U37_RS11545	COG1555	photosystem II stabilization
C2U37_RS11555	COG2350	Protein conserved in bacteria
C2U37_RS11560	COG2917	probably involved in intracellular septation
C2U37_RS11565	COG0076	glutamate decarboxylase activity
C2U37_RS11570	COG1272	protein, Hemolysin III
C2U37_RS11575	COG2985	domain, Protein
C2U37_RS11575	COG0569	domain protein
C2U37_RS11585	COG0477	Major facilitator Superfamily
C2U37_RS11590	COG0583	DNA-binding transcription factor activity
C2U37_RS11595	COG3227	Zinc metalloprotease (Elastase)
C2U37_RS11600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U37_RS11605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U37_RS11615	COG2731	YhcH YjgK YiaL family protein
C2U37_RS11625	COG0668	transmembrane transport
C2U37_RS11635	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U37_RS11645	COG0789	Transcriptional regulator
C2U37_RS11690	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U37_RS11700	COG0488	(ABC) transporter
C2U37_RS11705	COG0516	GMP reductase activity
C2U37_RS11705	COG0517	IMP dehydrogenase activity
C2U37_RS11715	COG0784	Response regulator, receiver
C2U37_RS11715	COG0835	chemotaxis
C2U37_RS11720	COG2755	lipolytic protein G-D-S-L family
C2U37_RS11725	COG4181	ATPase activity
C2U37_RS11730	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U37_RS11735	COG1090	epimerase
C2U37_RS11740	COG2200	EAL domain
C2U37_RS11745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U37_RS11750	COG2234	aminopeptidase activity
C2U37_RS11755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U37_RS11760	COG3171	Protein conserved in bacteria
C2U37_RS11765	COG2066	Belongs to the glutaminase family
C2U37_RS11770	COG2897	thiosulfate sulfurtransferase activity
C2U37_RS11775	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U37_RS11820	COG1132	(ABC) transporter
C2U37_RS11845	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C2U37_RS11850	COG3300	MHYT domain
C2U37_RS11850	COG5001	Diguanylate cyclase
C2U37_RS11870	COG4628	conserved protein (DUF2132)
C2U37_RS11875	COG0688	phosphatidylethanolamine metabolic process
C2U37_RS11880	COG1162	GTPase activity
C2U37_RS11885	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U37_RS11920	COG1278	Cold shock
C2U37_RS11930	COG0840	transmembrane signaling receptor activity
C2U37_RS11935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U37_RS11940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U37_RS11990	COG0848	biopolymer transport protein
C2U37_RS11995	COG0811	peptide transport
C2U37_RS12000	COG0811	peptide transport
C2U37_RS12010	COG4206	TonB-dependent receptor
C2U37_RS12015	COG4174	ABC transporter (Permease)
C2U37_RS12020	COG4239	(ABC) transporter, permease
C2U37_RS12030	COG0444	Belongs to the ABC transporter superfamily
C2U37_RS12035	COG4608	Belongs to the ABC transporter superfamily
C2U37_RS12045	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U37_RS12105	COG5301	cellulose 1,4-beta-cellobiosidase activity
C2U37_RS12195	COG4695	Portal protein
C2U37_RS12300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U37_RS12310	COG4974	Belongs to the 'phage' integrase family
C2U37_RS12315	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2U37_RS12320	COG1073	alpha beta
C2U37_RS12335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2U37_RS12360	COG0243	molybdopterin cofactor binding
C2U37_RS12365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U37_RS12365	COG1648	precorrin-2 dehydrogenase activity
C2U37_RS12375	COG1116	anion transmembrane transporter activity
C2U37_RS12375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U37_RS12380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U37_RS12385	COG1116	anion transmembrane transporter activity
C2U37_RS12390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U37_RS12390	COG2146	nitrite reductase [NAD(P)H] activity
C2U37_RS12395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U37_RS12395	COG2146	nitrite reductase [NAD(P)H] activity
C2U37_RS12400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U37_RS12405	COG2313	pseudouridylate synthase activity
C2U37_RS12425	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U37_RS12435	COG2966	Psort location CytoplasmicMembrane, score
C2U37_RS12440	COG3610	response to peptide
C2U37_RS12450	COG4175	Glycine betaine
C2U37_RS12455	COG4176	ABC-type proline glycine betaine transport system permease component
C2U37_RS12460	COG2113	Glycine betaine
C2U37_RS12465	COG0175	sulfate reduction
C2U37_RS12470	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U37_RS12475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U37_RS12480	COG0384	phenazine biosynthesis protein PhzF
C2U37_RS12485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2U37_RS12500	COG0786	glutamate:sodium symporter activity
C2U37_RS12505	COG0252	asparaginase activity
C2U37_RS12510	COG3139	Protein of unknown function (DUF1315)
C2U37_RS12530	COG0616	signal peptide processing
C2U37_RS12535	COG1902	pentaerythritol trinitrate reductase activity
C2U37_RS12535	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U37_RS12540	COG0778	Nitroreductase
C2U37_RS12560	COG2264	protein methyltransferase activity
C2U37_RS12565	COG0604	alcohol dehydrogenase
C2U37_RS12570	COG0583	DNA-binding transcription factor activity
C2U37_RS12575	COG1263	PTS System
C2U37_RS12575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U37_RS12575	COG2190	(PTS) system
C2U37_RS12580	COG4145	pantothenate transmembrane transporter activity
C2U37_RS12585	COG3924	membrane
C2U37_RS12590	COG0439	Biotin carboxylase
C2U37_RS12595	COG0511	ligase activity, forming carbon-carbon bonds
C2U37_RS12600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2U37_RS12605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U37_RS12620	COG3381	protein complex oligomerization
C2U37_RS12635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U37_RS12645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2U37_RS12650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U37_RS12650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U37_RS12665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2U37_RS12670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U37_RS12675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2U37_RS12680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U37_RS12685	COG4172	Belongs to the ABC transporter superfamily
C2U37_RS12695	COG0601	transmembrane transport
C2U37_RS12700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U37_RS12705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2U37_RS12710	COG0142	geranyltranstransferase activity
C2U37_RS12715	COG1722	exodeoxyribonuclease VII activity
C2U37_RS12720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U37_RS12725	COG1360	Flagellar Motor Protein
C2U37_RS12740	COG1534	Rna-binding protein
C2U37_RS12745	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2U37_RS12755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U37_RS12760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U37_RS12765	COG0149	triose-phosphate isomerase activity
C2U37_RS12770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U37_RS12785	COG0779	Required for maturation of 30S ribosomal subunits
C2U37_RS12790	COG0195	Participates in both transcription termination and antitermination
C2U37_RS12795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2U37_RS12800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U37_RS12805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U37_RS12810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2U37_RS12815	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U37_RS12820	COG2211	Major facilitator Superfamily
C2U37_RS12825	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U37_RS12830	COG1422	Protein of unknown function (DUF1090)
C2U37_RS12840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U37_RS12845	COG0826	peptidase U32
C2U37_RS12860	COG0312	modulator of DNA gyrase
C2U37_RS12870	COG0312	modulator of DNA gyrase
C2U37_RS12880	COG4974	Belongs to the 'phage' integrase family
C2U37_RS12885	COG1970	mechanosensitive ion channel activity
C2U37_RS12895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2U37_RS12900	COG0789	Transcriptional regulator
C2U37_RS12915	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U37_RS12925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U37_RS12930	COG0321	lipoyl(octanoyl) transferase activity
C2U37_RS12935	COG2921	Belongs to the UPF0250 family
C2U37_RS12940	COG1686	Belongs to the peptidase S11 family
C2U37_RS12945	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U37_RS12950	COG2951	lytic endotransglycosylase activity
C2U37_RS12955	COG0772	Belongs to the SEDS family
C2U37_RS12960	COG0768	penicillin binding
C2U37_RS12965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2U37_RS12970	COG0799	negative regulation of ribosome biogenesis
C2U37_RS12975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2U37_RS12990	COG0495	leucyl-tRNA aminoacylation
C2U37_RS12995	COG2888	peptidyl-tyrosine sulfation
C2U37_RS13000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2U37_RS13005	COG4535	Mg2 and Co2 transporter CorC
C2U37_RS13010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2U37_RS13015	COG1702	phosphate starvation-inducible protein PhoH
C2U37_RS13020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U37_RS13025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U37_RS13030	COG1335	isochorismatase
C2U37_RS13035	COG1278	Cold shock
C2U37_RS13050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U37_RS13055	COG2199	diguanylate cyclase activity
C2U37_RS13065	COG2199	diguanylate cyclase activity
C2U37_RS13075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U37_RS13090	COG1464	Belongs to the NlpA lipoprotein family
C2U37_RS13095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U37_RS13100	COG2011	ABC-type metal ion transport system permease component
C2U37_RS13105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U37_RS13115	COG0516	GMP reductase activity
C2U37_RS13120	COG4067	protein conserved in archaea
C2U37_RS13120	COG0189	ligase activity
C2U37_RS13140	COG0300	oxidoreductase activity
C2U37_RS13160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U37_RS13165	COG3214	Protein conserved in bacteria
C2U37_RS13180	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U37_RS13185	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U37_RS13190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U37_RS13195	COG1053	succinate dehydrogenase
C2U37_RS13205	COG0584	glycerophosphoryl diester phosphodiesterase
C2U37_RS13210	COG1511	domain protein
C2U37_RS13210	COG3264	Mechanosensitive ion channel
C2U37_RS13220	COG0739	heme binding
C2U37_RS13235	COG0583	DNA-binding transcription factor activity
C2U37_RS13250	COG0583	DNA-binding transcription factor activity
C2U37_RS13255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2U37_RS13285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U37_RS13290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2U37_RS13300	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2U37_RS13305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U37_RS13310	COG0546	phosphoglycolate phosphatase activity
C2U37_RS13315	COG0180	Tryptophanyl-tRNA synthetase
C2U37_RS13330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U37_RS13340	COG1012	belongs to the aldehyde dehydrogenase family
C2U37_RS13355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U37_RS13380	COG0490	domain, Protein
C2U37_RS13380	COG0471	metal ion transport
C2U37_RS13450	COG1196	nuclear chromosome segregation
C2U37_RS13455	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U37_RS13485	COG4644	lycopene metabolic process
C2U37_RS13520	COG0582	viral genome integration into host DNA
C2U37_RS13555	COG1309	transcriptional regulator
C2U37_RS13560	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_RS13575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U37_RS13580	COG0783	Belongs to the Dps family
C2U37_RS13600	COG0183	Belongs to the thiolase family
C2U37_RS13610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U37_RS13665	COG0625	glutathione transferase activity
C2U37_RS13670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U37_RS13680	COG0583	DNA-binding transcription factor activity
C2U37_RS13690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U37_RS13705	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U37_RS13725	COG1846	Transcriptional regulator
C2U37_RS13730	COG0583	DNA-binding transcription factor activity
C2U37_RS13740	COG2948	multi-organism process
C2U37_RS13755	COG3846	protein secretion by the type IV secretion system
C2U37_RS13770	COG3451	type IV secretory pathway VirB4
C2U37_RS13785	COG4962	Type ii secretion system protein e
C2U37_RS13805	COG0741	lytic transglycosylase activity
C2U37_RS13830	COG0840	transmembrane signaling receptor activity
C2U37_RS13845	COG4644	lycopene metabolic process
C2U37_RS13905	COG1484	DNA-dependent DNA replication
C2U37_RS13910	COG4584	PFAM Integrase catalytic
C2U37_RS14010	COG4974	Belongs to the 'phage' integrase family
C2U37_RS14025	COG0582	viral genome integration into host DNA
C2U37_RS14030	COG0012	GTP binding
C2U37_RS14035	COG0193	aminoacyl-tRNA hydrolase activity
C2U37_RS14040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U37_RS14050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2U37_RS14055	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U37_RS14060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2U37_RS14065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2U37_RS14070	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U37_RS14080	COG2912	Transglutaminase-like superfamily
C2U37_RS14085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2U37_RS14090	COG1301	dicarboxylic acid transport
C2U37_RS14100	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2U37_RS14115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U37_RS14120	COG1115	amino acid carrier protein
C2U37_RS14140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U37_RS14150	COG0189	ligase activity
C2U37_RS14155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U37_RS14165	COG3091	SprT-like family
C2U37_RS14175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U37_RS14200	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U37_RS14205	COG0739	heme binding
C2U37_RS14210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U37_RS14215	COG3408	Glycogen debranching enzyme
C2U37_RS14215	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C2U37_RS14225	COG1881	PFAM PEBP family protein
C2U37_RS14230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2U37_RS14235	COG0583	DNA-binding transcription factor activity
C2U37_RS14245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2U37_RS14255	COG0583	DNA-binding transcription factor activity
C2U37_RS14260	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_RS14265	COG0616	signal peptide processing
C2U37_RS14270	COG3724	N-succinylarginine dihydrolase activity
C2U37_RS14285	COG0840	transmembrane signaling receptor activity
C2U37_RS14295	COG2971	BadF BadG BcrA BcrD
C2U37_RS14305	COG4608	Belongs to the ABC transporter superfamily
C2U37_RS14310	COG0444	Belongs to the ABC transporter superfamily
C2U37_RS14315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U37_RS14330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U37_RS14385	COG5642	Protein of unknown function (DUF2384)
C2U37_RS14400	COG1538	Outer membrane efflux protein
C2U37_RS14405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_RS14410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_RS14420	COG0745	RESPONSE REGULATOR receiver
C2U37_RS14425	COG5002	protein histidine kinase activity
C2U37_RS14435	COG0789	Transcriptional regulator
C2U37_RS14475	COG2132	Multicopper oxidase
C2U37_RS14485	COG3039	Transposase
C2U37_RS14550	COG0640	Transcriptional regulator
C2U37_RS14555	COG0798	PFAM Bile acid sodium symporter
C2U37_RS14560	COG1393	Belongs to the ArsC family
C2U37_RS14570	COG1677	Flagellar hook-basal body complex protein FliE
C2U37_RS14580	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U37_RS14635	COG1684	flagellar biosynthetic protein fliR
C2U37_RS14645	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U37_RS14670	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2U37_RS14675	COG2198	Histidine kinase
C2U37_RS14675	COG0784	Response regulator, receiver
C2U37_RS14675	COG0643	Histidine kinase
C2U37_RS14680	COG2201	protein-glutamate methylesterase activity
C2U37_RS14685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U37_RS14690	COG1360	Flagellar Motor Protein
C2U37_RS14695	COG1192	Involved in chromosome partitioning
C2U37_RS14705	COG0835	chemotaxis
C2U37_RS14720	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U37_RS14725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U37_RS14730	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U37_RS14735	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2U37_RS14740	COG1138	Cytochrome C-type biogenesis protein
C2U37_RS14745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U37_RS14770	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U37_RS14775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U37_RS14775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U37_RS14790	COG0259	pyridoxamine-phosphate oxidase activity
C2U37_RS14820	COG3153	acetyltransferase
C2U37_RS14835	COG0800	Aldolase
C2U37_RS14865	COG1484	DNA-dependent DNA replication
C2U37_RS14870	COG4584	PFAM Integrase catalytic
C2U37_RS14900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U37_RS14925	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U37_RS14935	COG2801	Transposase and inactivated derivatives
C2U37_RS14985	COG3039	Transposase
C2U37_RS14995	COG2801	Transposase and inactivated derivatives
C2U37_RS15010	COG3039	Transposase
C2U37_RS15020	COG0582	viral genome integration into host DNA
C2U37_RS15070	COG1674	ftsk spoiiie
C2U37_RS15105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U37_RS15140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U37_RS15150	COG3645	SOS response
C2U37_RS15150	COG3646	Phage regulatory protein
C2U37_RS15195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U37_RS15360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2U37_RS15365	COG2867	negative regulation of translational initiation
C2U37_RS15370	COG2914	Belongs to the UPF0125 (RnfH) family
C2U37_RS15375	COG0702	epimerase
C2U37_RS15380	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U37_RS15385	COG1454	alcohol dehydrogenase
C2U37_RS15450	COG4382	Mu-like prophage protein Gp16
C2U37_RS15490	COG0640	Transcriptional regulator
C2U37_RS15500	COG4373	Mu-like prophage FluMu protein gp28
C2U37_RS15505	COG4383	Mu-like prophage protein gp29
C2U37_RS15510	COG2369	cell adhesion
C2U37_RS15520	COG4388	Caudovirus prohead serine protease
C2U37_RS15525	COG4397	Mu-like prophage major head subunit gpT
C2U37_RS15620	COG1957	nucleoside hydrolase
C2U37_RS15645	COG1280	lysine exporter protein (LysE YggA)
C2U37_RS15655	COG3263	regulation of cellular component size
C2U37_RS15665	COG1876	peptidase activity
C2U37_RS15670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U37_RS15675	COG1393	Belongs to the ArsC family
C2U37_RS15700	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U37_RS15705	COG0017	Asparaginyl-tRNA synthetase
C2U37_RS15725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U37_RS15730	COG0156	8-amino-7-oxononanoate synthase activity
C2U37_RS15735	COG2226	methyltransferase
C2U37_RS15735	COG1073	alpha beta
C2U37_RS15740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2U37_RS15745	COG0501	Belongs to the peptidase M48B family
C2U37_RS15750	COG0633	Ferredoxin
C2U37_RS15750	COG3217	Mosc domain protein beta barrel domain protein
C2U37_RS15750	COG0633	Ferredoxin
C2U37_RS15750	COG3217	Mosc domain protein beta barrel domain protein
C2U37_RS15760	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2U37_RS15760	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2U37_RS15760	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U37_RS15760	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2U37_RS15765	COG2841	Protein conserved in bacteria
C2U37_RS15775	COG0534	Mate efflux family protein
C2U37_RS15810	COG1309	transcriptional regulator
C2U37_RS15825	COG0791	NLP P60 protein
C2U37_RS15830	COG0583	DNA-binding transcription factor activity
C2U37_RS15850	COG0500	methyltransferase
C2U37_RS15855	COG4106	trans-aconitate 2-methyltransferase activity
C2U37_RS15860	COG1801	Protein of unknown function DUF72
C2U37_RS15870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2U37_RS15875	COG0217	transcriptional regulatory protein
C2U37_RS15880	COG2194	sulfuric ester hydrolase activity
C2U37_RS15885	COG1846	Transcriptional regulator
C2U37_RS15885	COG1940	carbohydrate kinase activity
C2U37_RS15890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U37_RS15895	COG0363	glucosamine-6-phosphate deaminase activity
C2U37_RS15900	COG2190	(PTS) system
C2U37_RS15900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U37_RS15900	COG1263	PTS System
C2U37_RS15910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U37_RS15915	COG0735	belongs to the Fur family
C2U37_RS15925	COG0716	FMN binding
C2U37_RS15940	COG0596	Alpha beta hydrolase
C2U37_RS15945	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C2U37_RS15950	COG0033	Phosphoglucomutase
C2U37_RS15960	COG1846	Transcriptional regulator
C2U37_RS15965	COG2951	lytic endotransglycosylase activity
C2U37_RS15970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U37_RS15975	COG4136	ATPase activity
C2U37_RS15985	COG4134	Bacterial extracellular solute-binding protein
C2U37_RS15990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U37_RS15995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U37_RS16005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U37_RS16015	COG0729	surface antigen
C2U37_RS16020	COG2911	Protein conserved in bacteria
C2U37_RS16040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U37_RS16050	COG0741	lytic transglycosylase activity
C2U37_RS16065	COG1607	acyl-coa hydrolase
C2U37_RS16080	COG0741	lytic transglycosylase activity
C2U37_RS16080	COG1388	LysM domain
C2U37_RS16085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U37_RS16090	COG2226	methyltransferase
C2U37_RS16095	COG0328	RNA-DNA hybrid ribonuclease activity
C2U37_RS16100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U37_RS16115	COG1960	acyl-CoA dehydrogenase activity
C2U37_RS16120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U37_RS16125	COG0121	glutamine amidotransferase
C2U37_RS16135	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2U37_RS16170	COG2197	response regulator
C2U37_RS16175	COG3850	Histidine kinase
C2U37_RS16180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U37_RS16185	COG0437	4 iron, 4 sulfur cluster binding
C2U37_RS16195	COG0243	molybdopterin cofactor binding
C2U37_RS16200	COG0437	4 iron, 4 sulfur cluster binding
C2U37_RS16205	COG0348	domain, Protein
C2U37_RS16215	COG3005	denitrification pathway
C2U37_RS16220	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U37_RS16225	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U37_RS16230	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2U37_RS16235	COG0314	molybdopterin synthase activity
C2U37_RS16250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2U37_RS16255	COG2267	carboxylic ester hydrolase activity
C2U37_RS16270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U37_RS16280	COG0302	gtp cyclohydrolase
C2U37_RS16285	COG0840	transmembrane signaling receptor activity
C2U37_RS16290	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C2U37_RS16300	COG0583	DNA-binding transcription factor activity
C2U37_RS16315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2U37_RS16330	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U37_RS16340	COG1166	arginine decarboxylase activity
C2U37_RS16370	COG3039	Transposase
C2U37_RS16395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U37_RS16400	COG1187	pseudouridine synthase activity
C2U37_RS16405	COG2807	transmembrane transport
C2U37_RS16415	COG0583	DNA-binding transcription factor activity
C2U37_RS16430	COG1607	acyl-coa hydrolase
C2U37_RS16435	COG2979	Protein of unknown function (DUF533)
C2U37_RS16445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U37_RS16450	COG1271	oxidase subunit
C2U37_RS16455	COG1294	oxidase, subunit
C2U37_RS16465	COG2814	Major facilitator Superfamily
C2U37_RS16470	COG0656	L-ascorbic acid biosynthetic process
C2U37_RS16485	COG3039	Transposase
C2U37_RS16500	COG0583	DNA-binding transcription factor activity
C2U37_RS16505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U37_RS16510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U37_RS16515	COG2271	Major facilitator Superfamily
C2U37_RS16520	COG1349	DNA-binding transcription factor activity
C2U37_RS16530	COG0584	glycerophosphoryl diester phosphodiesterase
C2U37_RS16535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U37_RS16540	COG0287	Prephenate dehydrogenase
C2U37_RS16540	COG1605	Chorismate mutase
C2U37_RS16550	COG3085	chromosome segregation
C2U37_RS16555	COG4574	serine-type endopeptidase inhibitor activity
C2U37_RS16575	COG1770	oligopeptidase
C2U37_RS16580	COG4771	TonB-dependent receptor
C2U37_RS16585	COG3083	sulfuric ester hydrolase activity
C2U37_RS16590	COG3082	Protein of unknown function (DUF1414)
C2U37_RS16595	COG3081	Nucleoid-associated protein
C2U37_RS16605	COG1175	transmembrane transport
C2U37_RS16610	COG3833	ABC-type maltose transport systems, permease component
C2U37_RS16615	COG3842	ATPase activity
C2U37_RS16625	COG0596	Alpha beta hydrolase
C2U37_RS16640	COG0425	Belongs to the sulfur carrier protein TusA family
C2U37_RS16645	COG4783	chaperone-mediated protein folding
C2U37_RS16655	COG1393	Belongs to the ArsC family
C2U37_RS16680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_RS16685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U37_RS16690	COG2431	L-lysine efflux transmembrane transporter activity
C2U37_RS16700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_RS16710	COG4160	amino acid transport
C2U37_RS16720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U37_RS16730	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U37_RS16745	COG1566	PFAM secretion protein HlyD family protein
C2U37_RS16755	COG0628	permease
C2U37_RS16760	COG2373	Large extracellular alpha-helical protein
C2U37_RS16765	COG4953	penicillin-binding protein 1C
C2U37_RS16775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U37_RS16775	COG0301	tRNA thio-modification
C2U37_RS16790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U37_RS16795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U37_RS16800	COG1334	flagellar protein FlaG
C2U37_RS16830	COG2089	acid synthase
C2U37_RS16845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U37_RS16850	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C2U37_RS16860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U37_RS16865	COG1086	Polysaccharide biosynthesis protein
C2U37_RS16870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U37_RS16880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U37_RS16900	COG3385	transposase activity
C2U37_RS16905	COG0346	lactoylglutathione lyase activity
C2U37_RS16910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U37_RS16915	COG4660	Part of a membrane complex involved in electron transport
C2U37_RS16920	COG4659	FMN binding
C2U37_RS16925	COG4658	electron transport chain
C2U37_RS16935	COG2878	Part of a membrane complex involved in electron transport
C2U37_RS16940	COG4657	Part of a membrane complex involved in electron transport
C2U37_RS16945	COG0675	Transposase, IS605 OrfB family
C2U37_RS16955	COG0697	spore germination
C2U37_RS16975	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U37_RS16985	COG0436	Aminotransferase
C2U37_RS16995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U37_RS17000	COG2027	D-alanyl-D-alanine carboxypeptidase
C2U37_RS17005	COG1061	Type III restriction enzyme res subunit
C2U37_RS17010	COG1566	PFAM secretion protein HlyD family protein
C2U37_RS17020	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2U37_RS17020	COG3264	Mechanosensitive ion channel
C2U37_RS17025	COG1966	Carbon starvation protein
C2U37_RS17030	COG3279	Response regulator of the LytR AlgR family
C2U37_RS17035	COG3275	phosphorelay sensor kinase activity
C2U37_RS17045	COG1454	alcohol dehydrogenase
C2U37_RS17045	COG1012	belongs to the aldehyde dehydrogenase family
C2U37_RS17050	COG2095	MarC family integral membrane protein
C2U37_RS17060	COG0601	transmembrane transport
C2U37_RS17065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U37_RS17070	COG0444	Belongs to the ABC transporter superfamily
C2U37_RS17080	COG0861	Integral membrane protein TerC family
C2U37_RS17085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U37_RS17095	COG1301	dicarboxylic acid transport
C2U37_RS17115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U37_RS17130	COG0537	adenosine 5'-monophosphoramidase activity
C2U37_RS17165	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U37_RS17170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U37_RS17185	COG2354	Protein conserved in bacteria
C2U37_RS17190	COG1164	Oligoendopeptidase f
C2U37_RS17195	COG1164	Oligoendopeptidase f
C2U37_RS17200	COG3150	esterase
C2U37_RS17205	COG1252	NADH dehydrogenase
C2U37_RS17210	COG0393	Putative heavy-metal-binding
C2U37_RS17215	COG1368	sulfuric ester hydrolase activity
C2U37_RS17225	COG0527	aspartate kinase activity
C2U37_RS17230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U37_RS17230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U37_RS17235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U37_RS17260	COG0583	DNA-binding transcription factor activity
C2U37_RS17265	COG1620	l-lactate permease
C2U37_RS17270	COG0247	lactate metabolic process
C2U37_RS17275	COG1139	Iron-sulfur cluster binding protein
C2U37_RS17295	COG0577	efflux transmembrane transporter activity
C2U37_RS17300	COG1136	(ABC) transporter
C2U37_RS17320	COG2814	Major facilitator Superfamily
C2U37_RS17345	COG0672	)-iron permease
C2U37_RS17380	COG2308	Evidence 4 Homologs of previously reported genes of
C2U37_RS17415	COG0659	secondary active sulfate transmembrane transporter activity
C2U37_RS17435	COG4584	PFAM Integrase catalytic
C2U37_RS17440	COG1484	DNA-dependent DNA replication
C2U37_RS17490	COG3706	GGDEF domain
C2U37_RS17505	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U37_RS17550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U37_RS17555	COG3039	Transposase
C2U37_RS17560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U37_RS17570	COG0326	Molecular chaperone. Has ATPase activity
C2U37_RS17575	COG0563	adenylate kinase activity
C2U37_RS17580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2U37_RS17585	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2U37_RS17590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U37_RS17595	COG0840	transmembrane signaling receptor activity
C2U37_RS17615	COG5001	Diguanylate cyclase
C2U37_RS17615	COG3300	MHYT domain
C2U37_RS17620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2U37_RS17640	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U37_RS17645	COG3433	isochorismatase activity
C2U37_RS17645	COG1535	isochorismatase
C2U37_RS17650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U37_RS17655	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_RS17665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U37_RS17685	COG1120	ATPase activity
C2U37_RS17690	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U37_RS17695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U37_RS17700	COG4771	TonB-dependent receptor
C2U37_RS17740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2U37_RS17745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U37_RS17750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U37_RS17755	COG0861	Integral membrane protein TerC family
C2U37_RS17770	COG1022	Amp-dependent synthetase and ligase
C2U37_RS17775	COG0295	cytidine deaminase activity
C2U37_RS17780	COG1346	cytolysis
C2U37_RS17785	COG1380	Effector of murein hydrolase LrgA
C2U37_RS17790	COG3345	alpha-galactosidase
C2U37_RS17800	COG2925	Exonuclease
C2U37_RS17805	COG0582	viral genome integration into host DNA
C2U37_RS17870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U37_RS17910	COG3646	Phage regulatory protein
C2U37_RS17965	COG1802	Transcriptional regulator
C2U37_RS17965	COG4626	Terminase
C2U37_RS18085	COG2801	Transposase and inactivated derivatives
C2U37_RS18090	COG3039	Transposase
C2U37_RS18125	COG0542	response to heat
C2U37_RS18150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2U37_RS18185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U37_RS18265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U37_RS18270	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2U37_RS18270	COG0392	lysyltransferase activity
C2U37_RS18285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U37_RS18290	COG0436	Aminotransferase
C2U37_RS18295	COG0583	DNA-binding transcription factor activity
C2U37_RS18300	COG2160	L-arabinose isomerase activity
C2U37_RS18310	COG1069	ribulokinase activity
C2U37_RS18315	COG1879	ABC-type sugar transport system periplasmic component
C2U37_RS18320	COG1129	ABC transporter
C2U37_RS18325	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U37_RS18335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U37_RS18340	COG0254	rRNA binding
C2U37_RS18355	COG1451	nucleotide metabolic process
C2U37_RS18370	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U37_RS18380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U37_RS18380	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2U37_RS18385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U37_RS18405	COG2009	succinate dehydrogenase
C2U37_RS18410	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U37_RS18425	COG0567	Dehydrogenase, E1 component
C2U37_RS18430	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U37_RS18435	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U37_RS18440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U37_RS18445	COG2983	Belongs to the UPF0260 family
C2U37_RS18460	COG4372	Transposase
C2U37_RS18465	COG1882	Formate acetyltransferase
C2U37_RS18470	COG2116	formate transmembrane transporter activity
C2U37_RS18475	COG1944	ATP diphosphatase activity
C2U37_RS18485	COG2076	Multidrug Resistance protein
C2U37_RS18490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U37_RS18495	COG1278	Cold shock
C2U37_RS18500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U37_RS18505	COG0542	response to heat
C2U37_RS18510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U37_RS18515	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2U37_RS18520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U37_RS18525	COG3134	Outer membrane lipoprotein
C2U37_RS18530	COG3706	GGDEF domain
C2U37_RS18535	COG0492	ferredoxin-NADP+ reductase activity
C2U37_RS18540	COG0686	Belongs to the AlaDH PNT family
C2U37_RS18550	COG1674	ftsk spoiiie
C2U37_RS18550	COG0531	amino acid
C2U37_RS18555	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U37_RS18560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U37_RS18570	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2U37_RS18575	COG1286	toxin biosynthetic process
C2U37_RS18580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2U37_RS18585	COG2723	6-phospho-beta-galactosidase activity
C2U37_RS18590	COG1263	PTS System
C2U37_RS18590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U37_RS18595	COG1609	Transcriptional regulator
C2U37_RS18605	COG4172	Belongs to the ABC transporter superfamily
C2U37_RS18615	COG4171	peptide transport system, permease
C2U37_RS18630	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2U37_RS18635	COG1842	Phage shock protein A
C2U37_RS18650	COG3106	COG3106 Predicted ATPase
C2U37_RS18655	COG3768	UPF0283 membrane protein
C2U37_RS18665	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2U37_RS18680	COG2199	diguanylate cyclase activity
C2U37_RS18685	COG2885	chlorophyll binding
C2U37_RS18725	COG0675	Transposase, IS605 OrfB family
C2U37_RS18740	COG0516	GMP reductase activity
C2U37_RS18740	COG0517	IMP dehydrogenase activity
C2U37_RS18745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U37_RS18745	COG0519	Catalyzes the synthesis of GMP from XMP
C2U37_RS18765	COG1846	Transcriptional regulator
C2U37_RS18785	COG2062	phosphohistidine phosphatase, SixA
C2U37_RS18795	COG0697	spore germination
C2U37_RS18805	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2U37_RS18810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U37_RS18820	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U37_RS18825	COG1136	(ABC) transporter
C2U37_RS18830	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U37_RS18835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2U37_RS18850	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2U37_RS18855	COG0740	serine-type endopeptidase activity
C2U37_RS18860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2U37_RS18865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U37_RS18870	COG0776	regulation of translation
C2U37_RS18875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U37_RS18880	COG0488	(ABC) transporter
C2U37_RS18885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U37_RS18890	COG3162	membrane
C2U37_RS18905	COG1024	Enoyl-CoA hydratase
C2U37_RS18910	COG1115	amino acid carrier protein
C2U37_RS18920	COG3228	Belongs to the MtfA family
C2U37_RS18925	COG1584	GPR1 FUN34 yaaH family protein
C2U37_RS18950	COG1024	Enoyl-CoA hydratase
C2U37_RS18955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U37_RS18960	COG1960	acyl-CoA dehydrogenase activity
C2U37_RS18970	COG1960	acyl-CoA dehydrogenase activity
C2U37_RS18975	COG1024	Enoyl-CoA hydratase
C2U37_RS18980	COG1024	Enoyl-CoA hydratase
C2U37_RS18990	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_RS19000	COG0730	response to heat
C2U37_RS19015	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U37_RS19020	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U37_RS19025	COG1129	ABC transporter
C2U37_RS19030	COG1879	ABC-type sugar transport system periplasmic component
C2U37_RS19035	COG0583	DNA-binding transcription factor activity
C2U37_RS19050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U37_RS19055	COG0243	molybdopterin cofactor binding
C2U37_RS19070	COG0583	DNA-binding transcription factor activity
C2U37_RS19075	COG2723	6-phospho-beta-galactosidase activity
C2U37_RS19085	COG0583	DNA-binding transcription factor activity
C2U37_RS19100	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2U37_RS19105	COG0673	inositol 2-dehydrogenase activity
C2U37_RS19110	COG0583	DNA-binding transcription factor activity
C2U37_RS19120	COG1560	Kdo2-lipid A biosynthetic process
C2U37_RS19125	COG1560	Kdo2-lipid A biosynthetic process
C2U37_RS19140	COG0417	DNA replication proofreading
C2U37_RS19170	COG0534	Mate efflux family protein
C2U37_RS19180	COG0307	riboflavin synthase, alpha
C2U37_RS19195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U37_RS19200	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2U37_RS19205	COG0697	spore germination
C2U37_RS19210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U37_RS19240	COG0675	Transposase, IS605 OrfB family
C2U37_RS19245	COG2996	Protein conserved in bacteria
C2U37_RS19265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U37_RS19270	COG3099	Belongs to the UPF0263 family
C2U37_RS19275	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2U37_RS19280	COG2894	cell division
C2U37_RS19285	COG0850	regulation of cytokinetic process
C2U37_RS19290	COG3100	YcgL domain-containing protein
C2U37_RS19295	COG2951	lytic endotransglycosylase activity
C2U37_RS19300	COG1760	l-serine dehydratase
C2U37_RS19310	COG1760	l-serine dehydratase
C2U37_RS19315	COG3123	guanosine phosphorylase activity
C2U37_RS19345	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2U37_RS19350	COG2067	long-chain fatty acid transport protein
C2U37_RS19355	COG2067	long-chain fatty acid transport protein
C2U37_RS19365	COG1595	DNA-templated transcription, initiation
C2U37_RS19395	COG0714	Associated with various cellular activities
C2U37_RS19400	COG0183	Belongs to the thiolase family
C2U37_RS19405	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U37_RS19405	COG1024	Enoyl-CoA hydratase
C2U37_RS19415	COG4681	YaeQ
C2U37_RS19425	COG3039	Transposase
C2U37_RS19445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U37_RS19460	COG3134	Outer membrane lipoprotein
C2U37_RS19465	COG0318	PFAM AMP-dependent synthetase and ligase
C2U37_RS19480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U37_RS19480	COG0140	phosphoribosyl-ATP diphosphatase activity
C2U37_RS19485	COG0107	imidazoleglycerol-phosphate synthase activity
C2U37_RS19490	COG0784	Response regulator, receiver
C2U37_RS19490	COG2205	protein histidine kinase activity
C2U37_RS19490	COG2198	Histidine kinase
C2U37_RS19500	COG3437	response regulator, receiver
C2U37_RS19505	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2U37_RS19510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U37_RS19515	COG0131	Imidazoleglycerol-phosphate dehydratase
C2U37_RS19515	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U37_RS19520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U37_RS19525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U37_RS19530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U37_RS19540	COG1199	ATP-dependent helicase activity
C2U37_RS19545	COG1214	PFAM Peptidase M22, glycoprotease
C2U37_RS19555	COG0596	Alpha beta hydrolase
C2U37_RS19560	COG0318	PFAM AMP-dependent synthetase and ligase
C2U37_RS19575	COG0697	spore germination
C2U37_RS19585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U37_RS19590	COG2832	Protein of unknown function (DUF454)
C2U37_RS19595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2U37_RS19605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2U37_RS19610	COG0583	DNA-binding transcription factor activity
C2U37_RS19620	COG3314	Sporulation integral membrane protein YlbJ
C2U37_RS19625	COG2197	response regulator
C2U37_RS19630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2U37_RS19630	COG0617	tRNA 3'-terminal CCA addition
C2U37_RS19630	COG0517	IMP dehydrogenase activity
C2U37_RS19635	COG1643	Atp-dependent helicase
C2U37_RS19645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2U37_RS19660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U37_RS19665	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2U37_RS19670	COG0709	Synthesizes selenophosphate from selenide and ATP
C2U37_RS19685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U37_RS19690	COG0840	transmembrane signaling receptor activity
C2U37_RS19695	COG1254	Belongs to the acylphosphatase family
C2U37_RS19705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U37_RS19705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U37_RS19710	COG0489	protein tyrosine kinase activity
C2U37_RS19715	COG0572	uridine kinase
C2U37_RS19720	COG0717	Belongs to the dCTP deaminase family
C2U37_RS19725	COG0306	phosphate transporter
C2U37_RS19730	COG4644	lycopene metabolic process
C2U37_RS19795	COG1530	ribonuclease E activity
C2U37_RS19800	COG0564	pseudouridine synthase activity
C2U37_RS19815	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U37_RS19820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2U37_RS19825	COG0416	fatty acid biosynthetic process
C2U37_RS19830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U37_RS19840	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_RS19845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U37_RS19850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U37_RS19855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U37_RS19860	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U37_RS19865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2U37_RS19870	COG0470	DNA polymerase III
C2U37_RS19875	COG0084	hydrolase, TatD family'
C2U37_RS19890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U37_RS19890	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C2U37_RS19895	COG3008	intermembrane lipid transfer
C2U37_RS19900	COG2995	paraquat-inducible protein a
C2U37_RS19910	COG3141	response to X-ray
C2U37_RS19920	COG1067	ATP-dependent peptidase activity
C2U37_RS19925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U37_RS19940	COG0488	(ABC) transporter
C2U37_RS19950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U37_RS19950	COG0116	Belongs to the methyltransferase superfamily
C2U37_RS19960	COG0167	dihydroorotate dehydrogenase activity
C2U37_RS19965	COG2902	Dehydrogenase
C2U37_RS19975	COG0308	aminopeptidase N
C2U37_RS19985	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2U37_RS19990	COG1956	GAF domain-containing protein
C2U37_RS20000	COG3278	Belongs to the heme-copper respiratory oxidase family
C2U37_RS20015	COG2010	Cytochrome c
C2U37_RS20025	COG2217	Heavy metal translocating P-type atpase
C2U37_RS20040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U37_RS20045	COG0589	response to stress
C2U37_RS20050	COG0037	tRNA processing
C2U37_RS20065	COG0675	Transposase, IS605 OrfB family
C2U37_RS20075	COG0625	glutathione transferase activity
C2U37_RS20080	COG1869	D-ribose catabolic process
C2U37_RS20085	COG1129	ABC transporter
C2U37_RS20090	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U37_RS20095	COG1879	ABC-type sugar transport system periplasmic component
C2U37_RS20100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U37_RS20105	COG1609	Transcriptional regulator
C2U37_RS20115	COG0675	Transposase, IS605 OrfB family
C2U37_RS20150	COG0776	regulation of translation
C2U37_RS20155	COG0072	phenylalanine-tRNA ligase activity
C2U37_RS20155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U37_RS20160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2U37_RS20180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2U37_RS20185	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U37_RS20190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2U37_RS20195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2U37_RS20220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U37_RS20230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U37_RS20235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U37_RS20240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U37_RS20245	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2U37_RS20250	COG3313	Fe-S protein
C2U37_RS20255	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U37_RS20255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U37_RS20255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U37_RS20260	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U37_RS20265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_RS20265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U37_RS20270	COG1609	Transcriptional regulator
C2U37_RS20275	COG0814	amino acid
C2U37_RS20285	COG5654	RES domain protein
C2U37_RS20290	COG0513	Belongs to the DEAD box helicase family
C2U37_RS20300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2U37_RS20305	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U37_RS20310	COG2840	Smr protein MutS2
C2U37_RS20345	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U37_RS20375	COG0588	phosphoglycerate mutase activity
C2U37_RS20405	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2U37_RS20410	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2U37_RS20420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U37_RS20425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2U37_RS20435	COG0205	6-phosphofructokinase activity
C2U37_RS20455	COG1473	amidohydrolase
C2U37_RS20460	COG1011	Hydrolase
C2U37_RS20465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U37_RS20510	COG3593	DNA synthesis involved in DNA repair
C2U37_RS20525	COG0583	DNA-binding transcription factor activity
C2U37_RS20530	COG0730	response to heat
C2U37_RS20535	COG3148	PFAM DTW domain containing protein
C2U37_RS20540	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U37_RS20550	COG0386	Belongs to the glutathione peroxidase family
C2U37_RS20555	COG0513	Belongs to the DEAD box helicase family
C2U37_RS20570	COG1742	UPF0060 membrane protein
C2U37_RS20595	COG2329	Antibiotic biosynthesis monooxygenase
C2U37_RS20600	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U37_RS20620	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U37_RS20630	COG2501	S4 domain
C2U37_RS20645	COG1132	(ABC) transporter
C2U37_RS20650	COG1132	(ABC) transporter
C2U37_RS20660	COG3118	belongs to the thioredoxin family
C2U37_RS20665	COG0471	metal ion transport
C2U37_RS20675	COG0058	SHG alpha-glucan phosphorylase activity
C2U37_RS20705	COG0814	amino acid
C2U37_RS20710	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2U37_RS20715	COG0514	ATP-dependent DNA helicase (RecQ)
C2U37_RS20720	COG2766	serine protein kinase
C2U37_RS20725	COG2718	Belongs to the UPF0229 family
C2U37_RS20730	COG2719	SpoVR family
C2U37_RS20735	COG2186	Transcriptional regulator
C2U37_RS20740	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U37_RS20745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U37_RS20750	COG0586	Pfam SNARE associated Golgi protein
C2U37_RS20760	COG0556	nucleotide-excision repair
C2U37_RS20775	COG2985	domain, Protein
C2U37_RS20775	COG0569	domain protein
C2U37_RS20780	COG0739	heme binding
C2U37_RS20780	COG0741	lytic transglycosylase activity
C2U37_RS20780	COG1196	nuclear chromosome segregation
C2U37_RS20800	COG4565	transcriptional regulatory protein
C2U37_RS20810	COG1940	carbohydrate kinase activity
C2U37_RS20810	COG1846	Transcriptional regulator
C2U37_RS20815	COG0840	transmembrane signaling receptor activity
C2U37_RS20820	COG3012	SEC-C Motif Domain Protein
C2U37_RS20825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2U37_RS20830	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C2U37_RS20835	COG0247	lactate metabolic process
C2U37_RS20860	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C2U37_RS20865	COG0437	4 iron, 4 sulfur cluster binding
C2U37_RS20870	COG3301	Polysulphide reductase, NrfD
C2U37_RS20875	COG1138	Cytochrome C-type biogenesis protein
C2U37_RS20880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U37_RS20885	COG4235	cytochrome complex assembly
C2U37_RS20885	COG3088	subunit of a heme lyase
C2U37_RS20900	COG3046	protein related to deoxyribodipyrimidine photolyase
C2U37_RS20905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U37_RS20920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2U37_RS20920	COG0517	IMP dehydrogenase activity
C2U37_RS20920	COG0617	tRNA 3'-terminal CCA addition
C2U37_RS20930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2U37_RS20945	COG4774	siderophore transport
C2U37_RS20950	COG3706	GGDEF domain
C2U37_RS20955	COG2200	EAL domain
C2U37_RS20960	COG1917	Cupin 2, conserved barrel domain protein
C2U37_RS20960	COG4977	sequence-specific DNA binding
C2U37_RS20965	COG0583	DNA-binding transcription factor activity
C2U37_RS20970	COG2910	NAD(P)H-binding
C2U37_RS20985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2U37_RS21015	COG2226	methyltransferase
C2U37_RS21070	COG2197	response regulator
C2U37_RS21085	COG3039	Transposase
C2U37_RS21125	COG3039	Transposase
C2U37_RS21135	COG1484	DNA-dependent DNA replication
C2U37_RS21140	COG4584	PFAM Integrase catalytic
C2U37_RS21185	COG3550	peptidyl-serine autophosphorylation
C2U37_RS21200	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2U37_RS21205	COG1349	DNA-binding transcription factor activity
C2U37_RS21220	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2U37_RS21230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U37_RS21250	COG3039	Transposase
C2U37_RS21260	COG4974	Belongs to the 'phage' integrase family
C2U37_RS21285	COG1435	thymidine kinase activity
C2U37_RS21290	COG1757	Na H antiporter
C2U37_RS21295	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U37_RS21300	COG2096	Adenosyltransferase
C2U37_RS21310	COG3530	Putative quorum-sensing-regulated virulence factor
C2U37_RS21315	COG0602	queuosine metabolic process
C2U37_RS21320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U37_RS21340	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2U37_RS21350	COG0776	regulation of translation
C2U37_RS21355	COG0539	negative regulation of cytoplasmic translation
C2U37_RS21360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2U37_RS21365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U37_RS21395	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2U37_RS21400	COG3300	MHYT domain
C2U37_RS21400	COG5001	Diguanylate cyclase
C2U37_RS21410	COG0583	DNA-binding transcription factor activity
C2U37_RS21415	COG0745	RESPONSE REGULATOR receiver
C2U37_RS21440	COG4989	oxidoreductase activity
C2U37_RS21445	COG0724	RNA recognition motif
C2U37_RS21455	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C2U37_RS21465	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U37_RS21485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U37_RS21490	COG1360	Flagellar Motor Protein
C2U37_RS21495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U37_RS21500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U37_RS21505	COG0649	NAD binding
C2U37_RS21505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U37_RS21520	COG1034	ATP synthesis coupled electron transport
C2U37_RS21525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2U37_RS21530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U37_RS21535	COG0839	Belongs to the complex I subunit 6 family
C2U37_RS21540	COG0713	ATP synthesis coupled electron transport
C2U37_RS21550	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U37_RS21555	COG1007	ATP synthesis coupled electron transport
C2U37_RS21560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U37_RS21560	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U37_RS21565	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U37_RS21570	COG1645	bacterial-type flagellum-dependent swarming motility
C2U37_RS21575	COG1160	GTP binding
C2U37_RS21580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U37_RS21585	COG2976	Protein conserved in bacteria
C2U37_RS21590	COG0124	histidyl-tRNA synthetase
C2U37_RS21600	COG1426	Protein conserved in bacteria
C2U37_RS21610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U37_RS21615	COG0105	UTP biosynthetic process
C2U37_RS21620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U37_RS21630	COG0633	Ferredoxin
C2U37_RS21635	COG0443	Heat shock 70 kDa protein
C2U37_RS21640	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U37_RS21650	COG0822	iron-sulfur transferase activity
C2U37_RS21655	COG1104	cysteine desulfurase activity
C2U37_RS21670	COG3154	lipid carrier protein
C2U37_RS21675	COG0826	peptidase U32
C2U37_RS21680	COG0826	peptidase U32
C2U37_RS21690	COG2897	thiosulfate sulfurtransferase activity
C2U37_RS21695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U37_RS21700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U37_RS21705	COG1862	Preprotein translocase
C2U37_RS21710	COG0343	queuine tRNA-ribosyltransferase activity
C2U37_RS21715	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2U37_RS21720	COG0517	IMP dehydrogenase activity
C2U37_RS21725	COG0450	alkyl hydroperoxide reductase
C2U37_RS21730	COG3634	alkyl hydroperoxide reductase activity
C2U37_RS21770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U37_RS21775	COG5642	Protein of unknown function (DUF2384)
C2U37_RS21820	COG4584	PFAM Integrase catalytic
C2U37_RS21825	COG1484	DNA-dependent DNA replication
C2U37_RS21845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U37_RS21845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U37_RS21850	COG0509	glycine decarboxylation via glycine cleavage system
C2U37_RS21855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U37_RS21860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U37_RS21865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U37_RS21885	COG2814	Major facilitator Superfamily
C2U37_RS21890	COG0444	Belongs to the ABC transporter superfamily
C2U37_RS21895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U37_RS21900	COG0601	transmembrane transport
C2U37_RS21910	COG0625	glutathione transferase activity
C2U37_RS21915	COG0625	glutathione transferase activity
C2U37_RS21925	COG0483	inositol monophosphate 1-phosphatase activity
C2U37_RS21940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U37_RS21945	COG2056	Na+-H+ antiporter family
C2U37_RS21950	COG2814	Major facilitator Superfamily
C2U37_RS21955	COG0583	DNA-binding transcription factor activity
C2U37_RS21960	COG5001	Diguanylate cyclase
C2U37_RS21975	COG2050	protein possibly involved in aromatic compounds catabolism
C2U37_RS21985	COG0277	FAD linked oxidase domain protein
C2U37_RS21985	COG0247	lactate metabolic process
C2U37_RS22000	COG1253	flavin adenine dinucleotide binding
C2U37_RS22005	COG1902	pentaerythritol trinitrate reductase activity
C2U37_RS22015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U37_RS22020	COG0647	UMP catabolic process
C2U37_RS22030	COG0367	asparagine synthase
C2U37_RS22045	COG0625	glutathione transferase activity
C2U37_RS22055	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C2U37_RS22070	COG0564	pseudouridine synthase activity
C2U37_RS22080	COG5001	Diguanylate cyclase
C2U37_RS22100	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2U37_RS22140	COG0670	Belongs to the BI1 family
C2U37_RS22145	COG1289	transmembrane transporter activity
C2U37_RS22150	COG2920	part of a sulfur-relay system
C2U37_RS22155	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2U37_RS22160	COG0285	dihydrofolate synthase activity
C2U37_RS22165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2U37_RS22170	COG0101	tRNA pseudouridine synthase activity
C2U37_RS22180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U37_RS22185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U37_RS22195	COG1464	Belongs to the NlpA lipoprotein family
C2U37_RS22220	COG1119	ATPase activity
C2U37_RS22225	COG0574	Belongs to the PEP-utilizing enzyme family
C2U37_RS22225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U37_RS22230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2U37_RS22240	COG1113	amino acid transport
C2U37_RS22285	COG1242	4 iron, 4 sulfur cluster binding
C2U37_RS22290	COG0070	glutamate synthase
C2U37_RS22290	COG0067	glutamate synthase
C2U37_RS22290	COG0069	glutamate synthase activity
C2U37_RS22295	COG0493	'glutamate synthase
C2U37_RS22300	COG1126	abc transporter atp-binding protein
C2U37_RS22305	COG0765	amino acid transport
C2U37_RS22310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_RS22335	COG4104	PAAR repeat-containing protein
C2U37_RS22345	COG0513	Belongs to the DEAD box helicase family
C2U37_RS22380	COG3706	GGDEF domain
C2U37_RS22385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U37_RS22425	COG3451	type IV secretory pathway VirB4
C2U37_RS22435	COG3838	Conjugal transfer protein Trbc
C2U37_RS22440	COG4962	Type ii secretion system protein e
C2U37_RS22460	COG0583	DNA-binding transcription factor activity
C2U37_RS22485	COG2076	Multidrug Resistance protein
C2U37_RS22510	COG4959	Type IV secretory pathway protease TraF
C2U37_RS22525	COG1192	Involved in chromosome partitioning
C2U37_RS22595	COG3077	Addiction module antitoxin, RelB DinJ family
C2U37_RS22605	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2U37_RS22620	COG4804	nuclease activity
C2U37_RS22635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2U37_RS22640	COG0505	Belongs to the CarA family
C2U37_RS22645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2U37_RS22655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U37_RS22660	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U37_RS22665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U37_RS22670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U37_RS22675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U37_RS22685	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C2U37_RS22715	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2U37_RS22725	COG0023	Translation Initiation Factor
C2U37_RS22730	COG2119	membrane
C2U37_RS22765	COG2199	diguanylate cyclase activity
C2U37_RS22765	COG2203	Gaf domain
C2U37_RS22775	COG3039	Transposase
C2U37_RS22790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U37_RS22800	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U37_RS22805	COG2261	transglycosylase associated protein
C2U37_RS22810	COG1309	transcriptional regulator
C2U37_RS22815	COG0604	alcohol dehydrogenase
C2U37_RS22825	COG2801	Transposase and inactivated derivatives
C2U37_RS22915	COG0322	excinuclease ABC activity
C2U37_RS22920	COG2197	response regulator
C2U37_RS22925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2U37_RS22930	COG2835	tetraacyldisaccharide 4'-kinase activity
C2U37_RS22935	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U37_RS22940	COG1132	(ABC) transporter
C2U37_RS22945	COG0658	competence protein
C2U37_RS22945	COG2333	competence protein COMEC
C2U37_RS22960	COG0433	COG0433 Predicted ATPase
C2U37_RS22965	COG1448	Aminotransferase
C2U37_RS22980	COG3385	transposase activity
C2U37_RS22990	COG1199	ATP-dependent helicase activity
C2U37_RS23000	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2U37_RS23005	COG0477	Major facilitator Superfamily
C2U37_RS23010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2U37_RS23015	COG1785	Belongs to the alkaline phosphatase family
C2U37_RS23035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U37_RS23040	COG3706	GGDEF domain
C2U37_RS23045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U37_RS23050	COG0765	amino acid transport
C2U37_RS23055	COG1126	abc transporter atp-binding protein
C2U37_RS23065	COG0531	amino acid
C2U37_RS23080	COG1253	flavin adenine dinucleotide binding
C2U37_RS23085	COG0704	Plays a role in the regulation of phosphate uptake
C2U37_RS23090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2U37_RS23095	COG0581	inorganic phosphate transmembrane transporter activity
C2U37_RS23100	COG0573	inorganic phosphate transmembrane transporter activity
C2U37_RS23105	COG0590	tRNA wobble adenosine to inosine editing
C2U37_RS23120	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U37_RS23140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2U37_RS23145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2U37_RS23150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U37_RS23155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U37_RS23180	COG2716	regulation of RNA biosynthetic process
C2U37_RS23185	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2U37_RS23195	COG2239	Acts as a magnesium transporter
C2U37_RS23210	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2U37_RS23210	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2U37_RS23215	COG1706	bacterial-type flagellum-dependent cell motility
C2U37_RS23220	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U37_RS23235	COG1749	Flagellar hook protein flgE
C2U37_RS23250	COG1815	bacterial-type flagellum-dependent cell motility
C2U37_RS23255	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2U37_RS23260	COG0784	Response regulator, receiver
C2U37_RS23260	COG0835	chemotaxis
C2U37_RS23265	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2U37_RS23280	COG0622	Phosphoesterase
C2U37_RS23285	COG4166	transmembrane transport
C2U37_RS23300	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U37_RS23310	COG0697	spore germination
C2U37_RS23315	COG4166	transmembrane transport
C2U37_RS23340	COG1278	Cold shock
C2U37_RS23380	COG3132	Protein of unknown function, DUF480
C2U37_RS23410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2U37_RS23415	COG1215	transferase activity, transferring glycosyl groups
C2U37_RS23430	COG2244	polysaccharide biosynthetic process
C2U37_RS23440	COG1028	Short-chain dehydrogenase reductase Sdr
C2U37_RS23445	COG1083	cytidylyl-transferase
C2U37_RS23450	COG0673	inositol 2-dehydrogenase activity
C2U37_RS23465	COG2089	acid synthase
C2U37_RS23470	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2U37_RS23475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U37_RS23505	COG1737	Transcriptional regulator
C2U37_RS23510	COG0469	pyruvate kinase activity
C2U37_RS23520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_RS23525	COG1960	acyl-CoA dehydrogenase activity
C2U37_RS23535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2U37_RS23550	COG4983	Phage plasmid primase, P4 family domain protein
C2U37_RS23575	COG4584	PFAM Integrase catalytic
C2U37_RS23580	COG1484	DNA-dependent DNA replication
C2U37_RS23595	COG3039	Transposase
C2U37_RS23610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U37_RS23635	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U37_RS23675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U37_RS23700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U37_RS23705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U37_RS23710	COG1309	transcriptional regulator
C2U37_RS23725	COG1946	Acyl-CoA thioesterase
C2U37_RS23740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U37_RS23750	COG0009	L-threonylcarbamoyladenylate synthase
C2U37_RS23755	COG0613	PHP domain protein
C2U37_RS23760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2U37_RS23765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U37_RS23765	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U37_RS23770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U37_RS23775	COG0135	phosphoribosylanthranilate isomerase activity
C2U37_RS23775	COG0134	indole-3-glycerol-phosphate synthase activity
C2U37_RS23780	COG0133	tryptophan synthase activity
C2U37_RS23785	COG0159	tryptophan synthase activity
C2U37_RS23795	COG3039	Transposase
C2U37_RS23830	COG4521	taurine ABC transporter
C2U37_RS23835	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U37_RS23840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U37_RS23845	COG2175	clavaminate synthase activity
C2U37_RS23855	COG5507	3-demethylubiquinone-9 3-methyltransferase
C2U37_RS23860	COG2814	Major facilitator Superfamily
C2U37_RS23865	COG0109	protoheme IX farnesyltransferase activity
C2U37_RS23870	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U37_RS23875	COG1845	cytochrome c oxidase, subunit III
C2U37_RS23880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U37_RS23885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U37_RS23895	COG0583	DNA-binding transcription factor activity
C2U37_RS23915	COG1846	Transcriptional regulator
C2U37_RS23930	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C2U37_RS23950	COG2026	Addiction module toxin, RelE StbE family
C2U37_RS23955	COG3077	Addiction module antitoxin, RelB DinJ family
C2U37_RS23960	COG1192	Involved in chromosome partitioning
C2U37_RS23970	COG4644	lycopene metabolic process
C2U37_RS24000	COG3385	transposase activity
C2U37_RS24140	COG2826	transposase and inactivated derivatives, IS30 family
C2U37_RS24155	COG2826	transposase and inactivated derivatives, IS30 family
C2U37_RS24160	COG3173	Aminoglycoside phosphotransferase
C2U37_RS24165	COG2826	transposase and inactivated derivatives, IS30 family
C2U37_RS24170	COG0488	(ABC) transporter
C2U37_RS24180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U37_RS24195	COG2826	transposase and inactivated derivatives, IS30 family
C2U37_RS24330	COG0789	Transcriptional regulator
C2U37_RS24335	COG2608	mercury ion transmembrane transporter activity
C2U37_RS24340	COG2608	mercury ion transmembrane transporter activity
C2U37_RS24350	COG0789	Transcriptional regulator
C2U37_RS24460	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U37_RS24500	COG0840	transmembrane signaling receptor activity