locus-tag	class	description
C2U40_RS00045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U40_RS00050	COG1459	type II secretion system
C2U40_RS00060	COG2165	general secretion pathway protein
C2U40_RS00095	COG1077	Cell shape determining protein MreB Mrl
C2U40_RS00100	COG1792	Involved in formation and maintenance of cell shape
C2U40_RS00105	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U40_RS00110	COG0424	maF-like protein
C2U40_RS00115	COG1530	ribonuclease E activity
C2U40_RS00120	COG3164	Protein of unknown function
C2U40_RS00130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U40_RS00135	COG0312	modulator of DNA gyrase
C2U40_RS00150	COG0477	Major facilitator Superfamily
C2U40_RS00160	COG3437	response regulator, receiver
C2U40_RS00165	COG5002	protein histidine kinase activity
C2U40_RS00165	COG0784	Response regulator, receiver
C2U40_RS00165	COG2205	protein histidine kinase activity
C2U40_RS00170	COG2172	sigma factor antagonist activity
C2U40_RS00175	COG1366	Belongs to the anti-sigma-factor antagonist family
C2U40_RS00195	COG3700	Belongs to the class B bacterial acid phosphatase family
C2U40_RS00205	COG2321	neutral zinc metallopeptidase
C2U40_RS00215	COG1639	'signal transduction protein
C2U40_RS00245	COG0189	ligase activity
C2U40_RS00255	COG0642	Histidine kinase
C2U40_RS00260	COG0745	RESPONSE REGULATOR receiver
C2U40_RS00275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2U40_RS00280	COG0352	thiamine-phosphate diphosphorylase activity
C2U40_RS00285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U40_RS00295	COG2022	thiamine diphosphate biosynthetic process
C2U40_RS00300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U40_RS00325	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C2U40_RS00350	COG0814	amino acid
C2U40_RS00355	COG3932	Exopolysaccharide synthesis, ExoD
C2U40_RS00375	COG1733	regulation of RNA biosynthetic process
C2U40_RS00415	COG1494	fructose-1,6-bisphosphatase
C2U40_RS00430	COG2959	enzyme of heme biosynthesis
C2U40_RS00440	COG0181	hydroxymethylbilane synthase activity
C2U40_RS00445	COG3072	Adenylate cyclase
C2U40_RS00450	COG0400	carboxylic ester hydrolase activity
C2U40_RS00455	COG1965	Belongs to the frataxin family
C2U40_RS00460	COG0019	diaminopimelate decarboxylase activity
C2U40_RS00465	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2U40_RS00480	COG1011	Hydrolase
C2U40_RS00500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2U40_RS00505	COG0561	phosphatase activity
C2U40_RS00520	COG1129	ABC transporter
C2U40_RS00520	COG0842	Transport permease protein
C2U40_RS00530	COG1546	Belongs to the CinA family
C2U40_RS00530	COG1058	Belongs to the CinA family
C2U40_RS00535	COG1418	mRNA catabolic process
C2U40_RS00540	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2U40_RS00550	COG1522	sequence-specific DNA binding
C2U40_RS00555	COG1368	sulfuric ester hydrolase activity
C2U40_RS00575	COG1285	pathogenesis
C2U40_RS00595	COG4221	oxidoreductase activity
C2U40_RS00615	COG1979	alcohol dehydrogenase
C2U40_RS00625	COG2873	o-acetylhomoserine
C2U40_RS00635	COG4533	DNA binding
C2U40_RS00650	COG5380	lipid catabolic process
C2U40_RS00655	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2U40_RS00670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2U40_RS00675	COG2949	membrane
C2U40_RS00680	COG3291	Pkd domain containing protein
C2U40_RS00690	COG3539	Fimbrial protein
C2U40_RS00700	COG3188	usher protein
C2U40_RS00705	COG3121	Chaperone
C2U40_RS00710	COG3539	Fimbrial protein
C2U40_RS00725	COG0318	PFAM AMP-dependent synthetase and ligase
C2U40_RS00730	COG1441	menaquinone biosynthetic process
C2U40_RS00735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2U40_RS00740	COG0596	Alpha beta hydrolase
C2U40_RS00745	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2U40_RS00750	COG1169	isochorismate synthase
C2U40_RS00755	COG1575	Belongs to the MenA family. Type 1 subfamily
C2U40_RS00780	COG0513	Belongs to the DEAD box helicase family
C2U40_RS00785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U40_RS00790	COG1988	membrane-bound metal-dependent
C2U40_RS00805	COG1671	Belongs to the UPF0178 family
C2U40_RS00830	COG3263	regulation of cellular component size
C2U40_RS00835	COG3722	fumarate hydratase activity
C2U40_RS00840	COG0246	Mannitol dehydrogenase
C2U40_RS00845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_RS00845	COG2213	PTS system mannitol-specific
C2U40_RS00855	COG1309	transcriptional regulator
C2U40_RS00860	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C2U40_RS00870	COG3916	Acyl-homoserine-lactone synthase
C2U40_RS00875	COG2771	luxR family
C2U40_RS00890	COG3133	Outer membrane lipoprotein
C2U40_RS00895	COG0456	acetyltransferase
C2U40_RS00915	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2U40_RS00920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U40_RS00930	COG3031	protein transport across the cell outer membrane
C2U40_RS00940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U40_RS00945	COG1459	type II secretion system
C2U40_RS00950	COG2165	general secretion pathway protein
C2U40_RS00965	COG2165	general secretion pathway protein
C2U40_RS00970	COG4795	General secretion pathway protein
C2U40_RS00975	COG3156	type II secretion system protein K
C2U40_RS00985	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C2U40_RS01000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U40_RS01005	COG1011	Hydrolase
C2U40_RS01010	COG0494	nUDIX hydrolase
C2U40_RS01015	COG1218	3'(2'),5'-bisphosphate nucleotidase
C2U40_RS01020	COG0814	amino acid
C2U40_RS01025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U40_RS01030	COG2207	Transcriptional regulator
C2U40_RS01030	COG3708	Transcriptional regulator
C2U40_RS01040	COG0626	cystathionine gamma-synthase activity
C2U40_RS01045	COG0527	aspartate kinase activity
C2U40_RS01045	COG0460	homoserine dehydrogenase
C2U40_RS01050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2U40_RS01060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U40_RS01065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U40_RS01075	COG0137	argininosuccinate synthase activity
C2U40_RS01080	COG0165	Argininosuccinate lyase
C2U40_RS01105	COG0110	maltose O-acetyltransferase activity
C2U40_RS01110	COG3174	membrane
C2U40_RS01115	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U40_RS01125	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U40_RS01130	COG4208	sulfate ABC transporter
C2U40_RS01135	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U40_RS01140	COG0583	DNA-binding transcription factor activity
C2U40_RS01145	COG3397	chitin binding
C2U40_RS01150	COG0840	transmembrane signaling receptor activity
C2U40_RS01185	COG4946	Tricorn protease homolog
C2U40_RS01185	COG0793	Belongs to the peptidase S41A family
C2U40_RS01205	COG1328	CTP reductase activity
C2U40_RS01210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U40_RS01225	COG1448	Aminotransferase
C2U40_RS01265	COG0513	Belongs to the DEAD box helicase family
C2U40_RS01285	COG0840	transmembrane signaling receptor activity
C2U40_RS01300	COG3112	Uncharacterised protein family (UPF0231)
C2U40_RS01305	COG3835	regulator
C2U40_RS01310	COG2610	gluconate transmembrane transporter activity
C2U40_RS01315	COG1929	Belongs to the glycerate kinase type-1 family
C2U40_RS01330	COG0583	DNA-binding transcription factor activity
C2U40_RS01335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U40_RS01350	COG0347	Belongs to the P(II) protein family
C2U40_RS01355	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U40_RS01365	COG3842	ATPase activity
C2U40_RS01370	COG2837	iron assimilation
C2U40_RS01375	COG1438	arginine binding
C2U40_RS01380	COG1126	abc transporter atp-binding protein
C2U40_RS01385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_RS01390	COG4215	(ABC) transporter
C2U40_RS01395	COG4160	amino acid transport
C2U40_RS01400	COG0039	L-malate dehydrogenase activity
C2U40_RS01405	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2U40_RS01410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U40_RS01410	COG1017	nitric oxide dioxygenase activity
C2U40_RS01420	COG4536	flavin adenine dinucleotide binding
C2U40_RS01425	COG4137	Cytochrome C assembly protein
C2U40_RS01430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U40_RS01435	COG0228	four-way junction DNA binding
C2U40_RS01440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U40_RS01445	COG0336	Belongs to the RNA methyltransferase TrmD family
C2U40_RS01450	COG0335	large ribosomal subunit rRNA binding
C2U40_RS01460	COG3066	DNA modification
C2U40_RS01470	COG1051	belongs to the nudix hydrolase family
C2U40_RS01480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2U40_RS01485	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2U40_RS01490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U40_RS01500	COG0583	DNA-binding transcription factor activity
C2U40_RS01505	COG0640	Transcriptional regulator
C2U40_RS01510	COG0268	Binds directly to 16S ribosomal RNA
C2U40_RS01515	COG0728	peptidoglycan biosynthetic process
C2U40_RS01520	COG0196	riboflavin kinase activity
C2U40_RS01525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U40_RS01530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2U40_RS01535	COG1047	Peptidyl-prolyl cis-trans
C2U40_RS01540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2U40_RS01545	COG4970	Tfp pilus assembly protein FimT
C2U40_RS01600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2U40_RS01600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U40_RS01615	COG1854	S-ribosylhomocysteine lyase activity
C2U40_RS01620	COG3706	GGDEF domain
C2U40_RS01625	COG0557	exoribonuclease II activity
C2U40_RS01630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U40_RS01645	COG2153	protein acetylation
C2U40_RS01665	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U40_RS01670	COG0360	Binds together with S18 to 16S ribosomal RNA
C2U40_RS01675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2U40_RS01680	COG0359	binds to the 23S rRNA
C2U40_RS01685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U40_RS01710	COG1238	metal cluster binding
C2U40_RS01715	COG0612	Peptidase, M16
C2U40_RS01720	COG2918	glutathione biosynthetic process
C2U40_RS01730	COG1022	Amp-dependent synthetase and ligase
C2U40_RS01740	COG0456	acetyltransferase
C2U40_RS01750	COG0714	Associated with various cellular activities
C2U40_RS01775	COG3385	transposase activity
C2U40_RS01800	COG1902	pentaerythritol trinitrate reductase activity
C2U40_RS01810	COG2852	Protein conserved in bacteria
C2U40_RS01825	COG2957	Belongs to the agmatine deiminase family
C2U40_RS01830	COG0154	amidase activity
C2U40_RS01860	COG0513	Belongs to the DEAD box helicase family
C2U40_RS01895	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C2U40_RS01900	COG1858	cytochrome C peroxidase
C2U40_RS01925	COG2070	2-Nitropropane dioxygenase
C2U40_RS01960	COG2816	NAD+ diphosphatase activity
C2U40_RS01965	COG2205	protein histidine kinase activity
C2U40_RS01970	COG0745	RESPONSE REGULATOR receiver
C2U40_RS01975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_RS01980	COG1136	(ABC) transporter
C2U40_RS01980	COG0577	efflux transmembrane transporter activity
C2U40_RS01985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_RS01990	COG1126	abc transporter atp-binding protein
C2U40_RS01995	COG0765	amino acid transport
C2U40_RS02000	COG0765	amino acid transport
C2U40_RS02005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U40_RS02010	COG1505	serine-type exopeptidase activity
C2U40_RS02030	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_RS02035	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U40_RS02050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U40_RS02055	COG4991	sh3 domain protein
C2U40_RS02070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2U40_RS02075	COG1940	carbohydrate kinase activity
C2U40_RS02080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U40_RS02085	COG0126	phosphoglycerate kinase activity
C2U40_RS02095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U40_RS02135	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U40_RS02145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U40_RS02150	COG1595	DNA-templated transcription, initiation
C2U40_RS02155	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2U40_RS02170	COG0481	GTPase activity
C2U40_RS02175	COG0681	Belongs to the peptidase S26 family
C2U40_RS02180	COG0571	ribonuclease III activity
C2U40_RS02190	COG1381	Involved in DNA repair and RecF pathway recombination
C2U40_RS02195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U40_RS02210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U40_RS02215	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_RS02220	COG3716	PTS system mannose fructose sorbose family IID component
C2U40_RS02230	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_RS02235	COG2222	sugar isomerase
C2U40_RS02245	COG1349	DNA-binding transcription factor activity
C2U40_RS02250	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U40_RS02255	COG4807	Protein conserved in bacteria
C2U40_RS02265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U40_RS02270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U40_RS02275	COG3956	TIGRFAM MazG family protein
C2U40_RS02280	COG0504	CTP synthase activity
C2U40_RS02285	COG0148	phosphopyruvate hydratase activity
C2U40_RS02290	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2U40_RS02295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2U40_RS02305	COG0585	pseudouridine synthase activity
C2U40_RS02310	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U40_RS02315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U40_RS02320	COG1238	metal cluster binding
C2U40_RS02335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2U40_RS02340	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U40_RS02345	COG1610	YqeY-like protein
C2U40_RS02350	COG0358	DNA primase activity
C2U40_RS02355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2U40_RS02385	COG0151	Belongs to the GarS family
C2U40_RS02390	COG0138	bifunctional purine biosynthesis protein purh
C2U40_RS02400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2U40_RS02405	COG3036	rescue of stalled ribosome
C2U40_RS02410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U40_RS02415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2U40_RS02425	COG0673	inositol 2-dehydrogenase activity
C2U40_RS02440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U40_RS02445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U40_RS02460	COG0477	Major facilitator Superfamily
C2U40_RS02475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U40_RS02480	COG1027	Aspartate ammonia-lyase
C2U40_RS02485	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2U40_RS02490	COG0534	Mate efflux family protein
C2U40_RS02495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2U40_RS02500	COG0459	protein refolding
C2U40_RS02510	COG5001	Diguanylate cyclase
C2U40_RS02510	COG3300	MHYT domain
C2U40_RS02520	COG0564	pseudouridine synthase activity
C2U40_RS02525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U40_RS02550	COG1280	lysine exporter protein (LysE YggA)
C2U40_RS02590	COG3311	Transcriptional regulator
C2U40_RS02630	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C2U40_RS02640	COG5377	YqaJ viral recombinase family
C2U40_RS02690	COG2003	Belongs to the UPF0758 family
C2U40_RS02740	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2U40_RS02745	COG0732	type I restriction modification DNA specificity domain
C2U40_RS02765	COG1484	DNA-dependent DNA replication
C2U40_RS02770	COG4584	PFAM Integrase catalytic
C2U40_RS02795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U40_RS02800	COG4584	PFAM Integrase catalytic
C2U40_RS02805	COG1484	DNA-dependent DNA replication
C2U40_RS02815	COG0732	type I restriction modification DNA specificity domain
C2U40_RS02840	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2U40_RS02855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_RS02885	COG0745	RESPONSE REGULATOR receiver
C2U40_RS02890	COG3104	oligopeptide transport
C2U40_RS02895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U40_RS02900	COG1555	photosystem II stabilization
C2U40_RS02910	COG2350	Protein conserved in bacteria
C2U40_RS02915	COG2917	probably involved in intracellular septation
C2U40_RS02920	COG0076	glutamate decarboxylase activity
C2U40_RS02925	COG1272	protein, Hemolysin III
C2U40_RS02930	COG2985	domain, Protein
C2U40_RS02930	COG0569	domain protein
C2U40_RS02940	COG0784	Response regulator, receiver
C2U40_RS02940	COG0835	chemotaxis
C2U40_RS02945	COG2755	lipolytic protein G-D-S-L family
C2U40_RS02950	COG4181	ATPase activity
C2U40_RS02955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U40_RS02960	COG1090	epimerase
C2U40_RS02965	COG2200	EAL domain
C2U40_RS02970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U40_RS02975	COG4935	Belongs to the peptidase S8 family
C2U40_RS02975	COG2234	aminopeptidase activity
C2U40_RS02980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U40_RS02985	COG3171	Protein conserved in bacteria
C2U40_RS02990	COG2066	Belongs to the glutaminase family
C2U40_RS02995	COG2897	thiosulfate sulfurtransferase activity
C2U40_RS03000	COG1404	Belongs to the peptidase S8 family
C2U40_RS03010	COG1132	(ABC) transporter
C2U40_RS03035	COG0582	viral genome integration into host DNA
C2U40_RS03055	COG4974	Belongs to the 'phage' integrase family
C2U40_RS03090	COG5001	Diguanylate cyclase
C2U40_RS03090	COG4251	negative regulation of phosphorylation
C2U40_RS03090	COG3706	GGDEF domain
C2U40_RS03090	COG2203	Gaf domain
C2U40_RS03105	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C2U40_RS03110	COG3300	MHYT domain
C2U40_RS03110	COG5001	Diguanylate cyclase
C2U40_RS03130	COG4628	conserved protein (DUF2132)
C2U40_RS03135	COG0688	phosphatidylethanolamine metabolic process
C2U40_RS03140	COG1162	GTPase activity
C2U40_RS03145	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U40_RS03185	COG1278	Cold shock
C2U40_RS03195	COG0840	transmembrane signaling receptor activity
C2U40_RS03200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U40_RS03205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U40_RS03255	COG0848	biopolymer transport protein
C2U40_RS03260	COG0811	peptide transport
C2U40_RS03265	COG0811	peptide transport
C2U40_RS03280	COG4174	ABC transporter (Permease)
C2U40_RS03285	COG4239	(ABC) transporter, permease
C2U40_RS03295	COG0444	Belongs to the ABC transporter superfamily
C2U40_RS03300	COG4608	Belongs to the ABC transporter superfamily
C2U40_RS03310	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U40_RS03320	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2U40_RS03325	COG1073	alpha beta
C2U40_RS03340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2U40_RS03365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U40_RS03370	COG2313	pseudouridylate synthase activity
C2U40_RS03375	COG3338	carbonate dehydratase activity
C2U40_RS03380	COG1858	cytochrome C peroxidase
C2U40_RS03415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U40_RS03420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U40_RS03470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U40_RS03480	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_RS03485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U40_RS03495	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U40_RS03505	COG2966	Psort location CytoplasmicMembrane, score
C2U40_RS03510	COG3610	response to peptide
C2U40_RS03520	COG4175	Glycine betaine
C2U40_RS03525	COG4176	ABC-type proline glycine betaine transport system permease component
C2U40_RS03530	COG2113	Glycine betaine
C2U40_RS03535	COG0175	sulfate reduction
C2U40_RS03540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U40_RS03545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U40_RS03550	COG0384	phenazine biosynthesis protein PhzF
C2U40_RS03555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2U40_RS03570	COG0786	glutamate:sodium symporter activity
C2U40_RS03575	COG0252	asparaginase activity
C2U40_RS03580	COG3139	Protein of unknown function (DUF1315)
C2U40_RS03600	COG0616	signal peptide processing
C2U40_RS03605	COG1902	pentaerythritol trinitrate reductase activity
C2U40_RS03605	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U40_RS03610	COG0778	Nitroreductase
C2U40_RS03625	COG2264	protein methyltransferase activity
C2U40_RS03635	COG0604	alcohol dehydrogenase
C2U40_RS03640	COG0583	DNA-binding transcription factor activity
C2U40_RS03645	COG1263	PTS System
C2U40_RS03645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_RS03645	COG2190	(PTS) system
C2U40_RS03650	COG4145	pantothenate transmembrane transporter activity
C2U40_RS03660	COG0439	Biotin carboxylase
C2U40_RS03665	COG0511	ligase activity, forming carbon-carbon bonds
C2U40_RS03670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2U40_RS03675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U40_RS03685	COG3300	MHYT domain
C2U40_RS03685	COG5001	Diguanylate cyclase
C2U40_RS03705	COG3381	protein complex oligomerization
C2U40_RS03715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U40_RS03730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2U40_RS03735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U40_RS03735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U40_RS03755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2U40_RS03760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U40_RS03765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2U40_RS03770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U40_RS03775	COG4172	Belongs to the ABC transporter superfamily
C2U40_RS03785	COG0601	transmembrane transport
C2U40_RS03795	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2U40_RS03800	COG0142	geranyltranstransferase activity
C2U40_RS03805	COG1722	exodeoxyribonuclease VII activity
C2U40_RS03810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U40_RS03815	COG1360	Flagellar Motor Protein
C2U40_RS03830	COG1534	Rna-binding protein
C2U40_RS03835	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2U40_RS03845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U40_RS03850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U40_RS03855	COG0149	triose-phosphate isomerase activity
C2U40_RS03860	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U40_RS03875	COG0779	Required for maturation of 30S ribosomal subunits
C2U40_RS03880	COG0195	Participates in both transcription termination and antitermination
C2U40_RS03885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2U40_RS03890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U40_RS03895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U40_RS03900	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2U40_RS03905	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U40_RS03910	COG3385	transposase activity
C2U40_RS03915	COG2211	Major facilitator Superfamily
C2U40_RS03925	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U40_RS03935	COG0114	fumarate hydratase activity
C2U40_RS03945	COG1966	Carbon starvation protein
C2U40_RS03950	COG3279	Response regulator of the LytR AlgR family
C2U40_RS03955	COG3275	phosphorelay sensor kinase activity
C2U40_RS04020	COG0312	modulator of DNA gyrase
C2U40_RS04025	COG0312	modulator of DNA gyrase
C2U40_RS04035	COG4974	Belongs to the 'phage' integrase family
C2U40_RS04040	COG1970	mechanosensitive ion channel activity
C2U40_RS04045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U40_RS04055	COG0789	Transcriptional regulator
C2U40_RS04070	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U40_RS04075	COG3545	Serine hydrolase
C2U40_RS04085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U40_RS04095	COG0321	lipoyl(octanoyl) transferase activity
C2U40_RS04100	COG2921	Belongs to the UPF0250 family
C2U40_RS04105	COG1686	Belongs to the peptidase S11 family
C2U40_RS04110	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U40_RS04115	COG2951	lytic endotransglycosylase activity
C2U40_RS04120	COG0772	Belongs to the SEDS family
C2U40_RS04125	COG0768	penicillin binding
C2U40_RS04130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2U40_RS04135	COG0799	negative regulation of ribosome biogenesis
C2U40_RS04140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2U40_RS04160	COG0495	leucyl-tRNA aminoacylation
C2U40_RS04165	COG2888	peptidyl-tyrosine sulfation
C2U40_RS04170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2U40_RS04175	COG4535	Mg2 and Co2 transporter CorC
C2U40_RS04180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2U40_RS04185	COG1702	phosphate starvation-inducible protein PhoH
C2U40_RS04190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U40_RS04195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U40_RS04200	COG1335	isochorismatase
C2U40_RS04210	COG3706	GGDEF domain
C2U40_RS04225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U40_RS04235	COG3706	GGDEF domain
C2U40_RS04245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U40_RS04255	COG3647	Membrane
C2U40_RS04260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U40_RS04275	COG0516	GMP reductase activity
C2U40_RS04295	COG0642	Histidine kinase
C2U40_RS04330	COG4106	trans-aconitate 2-methyltransferase activity
C2U40_RS04335	COG3214	Protein conserved in bacteria
C2U40_RS04360	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U40_RS04365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U40_RS04370	COG1053	succinate dehydrogenase
C2U40_RS04380	COG0584	glycerophosphoryl diester phosphodiesterase
C2U40_RS04385	COG3264	Mechanosensitive ion channel
C2U40_RS04385	COG1511	domain protein
C2U40_RS04395	COG0739	heme binding
C2U40_RS04410	COG0583	DNA-binding transcription factor activity
C2U40_RS04430	COG0583	DNA-binding transcription factor activity
C2U40_RS04435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2U40_RS04465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U40_RS04470	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2U40_RS04480	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2U40_RS04495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U40_RS04505	COG0180	Tryptophanyl-tRNA synthetase
C2U40_RS04520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U40_RS04530	COG1012	belongs to the aldehyde dehydrogenase family
C2U40_RS04540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U40_RS04550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2U40_RS04550	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2U40_RS04550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_RS04550	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2U40_RS04560	COG0366	Alpha amylase catalytic
C2U40_RS04580	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C2U40_RS04590	COG0471	metal ion transport
C2U40_RS04590	COG0490	domain, Protein
C2U40_RS04675	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U40_RS04750	COG0582	viral genome integration into host DNA
C2U40_RS04755	COG0012	GTP binding
C2U40_RS04760	COG0193	aminoacyl-tRNA hydrolase activity
C2U40_RS04765	COG0737	Belongs to the 5'-nucleotidase family
C2U40_RS04770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U40_RS04780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2U40_RS04785	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U40_RS04790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2U40_RS04795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2U40_RS04800	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U40_RS04810	COG2912	Transglutaminase-like superfamily
C2U40_RS04815	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2U40_RS04820	COG1301	dicarboxylic acid transport
C2U40_RS04830	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2U40_RS04845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U40_RS04850	COG1115	amino acid carrier protein
C2U40_RS04865	COG0714	Associated with various cellular activities
C2U40_RS04875	COG3104	oligopeptide transport
C2U40_RS04880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U40_RS04885	COG1678	Uncharacterized ACR, COG1678
C2U40_RS04895	COG0189	ligase activity
C2U40_RS04900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U40_RS04910	COG3091	SprT-like family
C2U40_RS04920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U40_RS04940	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U40_RS04945	COG0739	heme binding
C2U40_RS04950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U40_RS04955	COG3408	Glycogen debranching enzyme
C2U40_RS04955	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C2U40_RS04965	COG1881	PFAM PEBP family protein
C2U40_RS04970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2U40_RS04975	COG0583	DNA-binding transcription factor activity
C2U40_RS04985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2U40_RS04995	COG0583	DNA-binding transcription factor activity
C2U40_RS05000	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_RS05005	COG0616	signal peptide processing
C2U40_RS05010	COG3724	N-succinylarginine dihydrolase activity
C2U40_RS05030	COG0840	transmembrane signaling receptor activity
C2U40_RS05040	COG2971	BadF BadG BcrA BcrD
C2U40_RS05050	COG4608	Belongs to the ABC transporter superfamily
C2U40_RS05055	COG0444	Belongs to the ABC transporter superfamily
C2U40_RS05060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U40_RS05065	COG0601	transmembrane transport
C2U40_RS05070	COG4166	transmembrane transport
C2U40_RS05075	COG0784	Response regulator, receiver
C2U40_RS05075	COG2205	protein histidine kinase activity
C2U40_RS05105	COG3220	belongs to the UPF0276 family
C2U40_RS05135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U40_RS05140	COG1289	transmembrane transporter activity
C2U40_RS05145	COG0303	'Molybdopterin
C2U40_RS05150	COG0746	molybdenum cofactor guanylyltransferase activity
C2U40_RS05160	COG4662	Binding-protein-dependent transport system inner membrane component
C2U40_RS05170	COG2204	response regulator
C2U40_RS05175	COG3852	Histidine kinase
C2U40_RS05180	COG1910	domain protein
C2U40_RS05185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U40_RS05200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U40_RS05230	COG3383	formate dehydrogenase (NAD+) activity
C2U40_RS05230	COG3383	formate dehydrogenase (NAD+) activity
C2U40_RS05235	COG0437	4 iron, 4 sulfur cluster binding
C2U40_RS05250	COG0281	malic enzyme
C2U40_RS05270	COG2706	6-phosphogluconolactonase activity
C2U40_RS05285	COG3264	Mechanosensitive ion channel
C2U40_RS05285	COG1196	nuclear chromosome segregation
C2U40_RS05290	COG0469	pyruvate kinase activity
C2U40_RS05305	COG4651	solute:proton antiporter activity
C2U40_RS05305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U40_RS05315	COG2974	May be involved in recombination
C2U40_RS05325	COG0420	3'-5' exonuclease activity
C2U40_RS05330	COG0419	ATPase involved in DNA repair
C2U40_RS05345	COG3038	cytochrome b561
C2U40_RS05360	COG2190	(PTS) system
C2U40_RS05370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_RS05375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U40_RS05380	COG0542	response to heat
C2U40_RS05395	COG1720	tRNA m6t6A37 methyltransferase activity
C2U40_RS05415	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2U40_RS05420	COG4988	ABC transporter
C2U40_RS05435	COG0745	RESPONSE REGULATOR receiver
C2U40_RS05445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U40_RS05460	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2U40_RS05465	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2U40_RS05480	COG0083	homoserine kinase activity
C2U40_RS05485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U40_RS05520	COG0813	purine-nucleoside phosphorylase activity
C2U40_RS05535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_RS05535	COG2205	protein histidine kinase activity
C2U40_RS05540	COG3384	dioxygenase
C2U40_RS05550	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2U40_RS05560	COG0531	amino acid
C2U40_RS05575	COG0531	amino acid
C2U40_RS05590	COG1917	Cupin 2, conserved barrel domain protein
C2U40_RS05590	COG1396	sequence-specific DNA binding
C2U40_RS05595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U40_RS05615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U40_RS05625	COG2375	cellular response to nickel ion
C2U40_RS05635	COG1136	(ABC) transporter
C2U40_RS05635	COG0577	efflux transmembrane transporter activity
C2U40_RS05640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_RS05650	COG1227	inorganic diphosphatase activity
C2U40_RS05660	COG0497	DNA recombination
C2U40_RS05665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U40_RS05670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2U40_RS05675	COG0443	Heat shock 70 kDa protein
C2U40_RS05680	COG0484	heat shock protein binding
C2U40_RS05715	COG1285	pathogenesis
C2U40_RS05730	COG0640	Transcriptional regulator
C2U40_RS05740	COG2391	methyltransferase activity
C2U40_RS05760	COG0095	Lipoate-protein ligase
C2U40_RS05780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U40_RS05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_RS05805	COG0708	Exodeoxyribonuclease III
C2U40_RS05820	COG2211	Major facilitator Superfamily
C2U40_RS05875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U40_RS05880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U40_RS05885	COG1845	cytochrome c oxidase, subunit III
C2U40_RS05890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U40_RS05895	COG0109	protoheme IX farnesyltransferase activity
C2U40_RS05900	COG2814	Major facilitator Superfamily
C2U40_RS05910	COG2205	protein histidine kinase activity
C2U40_RS05910	COG2198	Histidine kinase
C2U40_RS05910	COG0784	Response regulator, receiver
C2U40_RS05915	COG1879	ABC-type sugar transport system periplasmic component
C2U40_RS05925	COG0745	RESPONSE REGULATOR receiver
C2U40_RS05930	COG3005	denitrification pathway
C2U40_RS05940	COG3381	protein complex oligomerization
C2U40_RS05980	COG2003	Belongs to the UPF0758 family
C2U40_RS06020	COG0583	DNA-binding transcription factor activity
C2U40_RS06035	COG0549	Belongs to the carbamate kinase family
C2U40_RS06040	COG1304	FMN binding
C2U40_RS06045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U40_RS06050	COG1335	isochorismatase
C2U40_RS06065	COG3311	Transcriptional regulator
C2U40_RS06095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U40_RS06115	COG3550	peptidyl-serine autophosphorylation
C2U40_RS06120	COG1396	sequence-specific DNA binding
C2U40_RS06125	COG1988	membrane-bound metal-dependent
C2U40_RS06140	COG3039	Transposase
C2U40_RS06150	COG0159	tryptophan synthase activity
C2U40_RS06155	COG0133	tryptophan synthase activity
C2U40_RS06160	COG0135	phosphoribosylanthranilate isomerase activity
C2U40_RS06160	COG0134	indole-3-glycerol-phosphate synthase activity
C2U40_RS06165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U40_RS06170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U40_RS06170	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U40_RS06175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2U40_RS06185	COG0009	L-threonylcarbamoyladenylate synthase
C2U40_RS06195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U40_RS06205	COG1946	Acyl-CoA thioesterase
C2U40_RS06220	COG1309	transcriptional regulator
C2U40_RS06225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_RS06230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U40_RS06245	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2U40_RS06260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U40_RS06280	COG0367	asparagine synthase
C2U40_RS06290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2U40_RS06310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2U40_RS06325	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2U40_RS06340	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C2U40_RS06350	COG3132	Protein of unknown function, DUF480
C2U40_RS06390	COG1278	Cold shock
C2U40_RS06415	COG4166	transmembrane transport
C2U40_RS06420	COG0697	spore germination
C2U40_RS06425	COG1349	DNA-binding transcription factor activity
C2U40_RS06430	COG1882	Formate acetyltransferase
C2U40_RS06435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U40_RS06440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U40_RS06470	COG0622	Phosphoesterase
C2U40_RS06485	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2U40_RS06490	COG0835	chemotaxis
C2U40_RS06490	COG0784	Response regulator, receiver
C2U40_RS06495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2U40_RS06500	COG1815	bacterial-type flagellum-dependent cell motility
C2U40_RS06515	COG1749	Flagellar hook protein flgE
C2U40_RS06520	COG4787	bacterial-type flagellum-dependent cell motility
C2U40_RS06530	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U40_RS06535	COG1706	bacterial-type flagellum-dependent cell motility
C2U40_RS06545	COG1256	bacterial-type flagellum assembly
C2U40_RS06555	COG2239	Acts as a magnesium transporter
C2U40_RS06560	COG3437	response regulator, receiver
C2U40_RS06560	COG0784	Response regulator, receiver
C2U40_RS06565	COG1960	acyl-CoA dehydrogenase activity
C2U40_RS06570	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U40_RS06575	COG0121	glutamine amidotransferase
C2U40_RS06605	COG2197	response regulator
C2U40_RS06610	COG3850	Histidine kinase
C2U40_RS06615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U40_RS06620	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U40_RS06620	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U40_RS06630	COG0243	molybdopterin cofactor binding
C2U40_RS06635	COG0437	4 iron, 4 sulfur cluster binding
C2U40_RS06640	COG0348	domain, Protein
C2U40_RS06650	COG3005	denitrification pathway
C2U40_RS06655	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U40_RS06660	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U40_RS06665	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2U40_RS06670	COG0314	molybdopterin synthase activity
C2U40_RS06685	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2U40_RS06690	COG2267	carboxylic ester hydrolase activity
C2U40_RS06715	COG0433	COG0433 Predicted ATPase
C2U40_RS06750	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U40_RS06755	COG2835	tetraacyldisaccharide 4'-kinase activity
C2U40_RS06760	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2U40_RS06765	COG2197	response regulator
C2U40_RS06770	COG0322	excinuclease ABC activity
C2U40_RS06830	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C2U40_RS06835	COG0437	4 iron, 4 sulfur cluster binding
C2U40_RS06840	COG3301	Polysulphide reductase, NrfD
C2U40_RS06845	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U40_RS06855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U40_RS06885	COG2203	Gaf domain
C2U40_RS06885	COG2199	diguanylate cyclase activity
C2U40_RS06915	COG2119	membrane
C2U40_RS06920	COG0023	Translation Initiation Factor
C2U40_RS06945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2U40_RS06960	COG2205	protein histidine kinase activity
C2U40_RS06960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_RS06970	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C2U40_RS06980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U40_RS06985	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U40_RS06990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U40_RS06995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U40_RS07000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U40_RS07010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2U40_RS07015	COG0505	Belongs to the CarA family
C2U40_RS07020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2U40_RS07025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U40_RS07055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U40_RS07060	COG0513	Belongs to the DEAD box helicase family
C2U40_RS07070	COG4104	PAAR repeat-containing protein
C2U40_RS07085	COG0789	Transcriptional regulator
C2U40_RS07100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_RS07105	COG0765	amino acid transport
C2U40_RS07110	COG1126	abc transporter atp-binding protein
C2U40_RS07115	COG0493	'glutamate synthase
C2U40_RS07120	COG0070	glutamate synthase
C2U40_RS07120	COG0069	glutamate synthase activity
C2U40_RS07120	COG0067	glutamate synthase
C2U40_RS07125	COG1242	4 iron, 4 sulfur cluster binding
C2U40_RS07195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2U40_RS07200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U40_RS07200	COG0574	Belongs to the PEP-utilizing enzyme family
C2U40_RS07240	COG1464	Belongs to the NlpA lipoprotein family
C2U40_RS07245	COG0671	phosphoesterase, PA-phosphatase related
C2U40_RS07250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U40_RS07255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U40_RS07265	COG0101	tRNA pseudouridine synthase activity
C2U40_RS07270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2U40_RS07275	COG0285	dihydrofolate synthase activity
C2U40_RS07280	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2U40_RS07285	COG2920	part of a sulfur-relay system
C2U40_RS07290	COG1289	transmembrane transporter activity
C2U40_RS07295	COG0670	Belongs to the BI1 family
C2U40_RS07310	COG4792	protein secretion
C2U40_RS07315	COG4791	protein targeting
C2U40_RS07320	COG4794	Type iii secretion
C2U40_RS07325	COG4790	Type iii secretion
C2U40_RS07485	COG1317	bacterial-type flagellum organization
C2U40_RS07500	COG2194	sulfuric ester hydrolase activity
C2U40_RS07510	COG0392	lysyltransferase activity
C2U40_RS07510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2U40_RS07520	COG0840	transmembrane signaling receptor activity
C2U40_RS07525	COG5001	Diguanylate cyclase
C2U40_RS07530	COG0564	pseudouridine synthase activity
C2U40_RS07545	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C2U40_RS07560	COG0625	glutathione transferase activity
C2U40_RS07565	COG0625	glutathione transferase activity
C2U40_RS07575	COG0367	asparagine synthase
C2U40_RS07585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U40_RS07585	COG4651	solute:proton antiporter activity
C2U40_RS07590	COG0647	UMP catabolic process
C2U40_RS07605	COG1902	pentaerythritol trinitrate reductase activity
C2U40_RS07610	COG1253	flavin adenine dinucleotide binding
C2U40_RS07620	COG0277	FAD linked oxidase domain protein
C2U40_RS07620	COG0247	lactate metabolic process
C2U40_RS07630	COG2050	protein possibly involved in aromatic compounds catabolism
C2U40_RS07640	COG2056	Na+-H+ antiporter family
C2U40_RS07645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U40_RS07660	COG0346	lactoylglutathione lyase activity
C2U40_RS07665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U40_RS07670	COG4660	Part of a membrane complex involved in electron transport
C2U40_RS07675	COG4659	FMN binding
C2U40_RS07680	COG4658	electron transport chain
C2U40_RS07690	COG2878	Part of a membrane complex involved in electron transport
C2U40_RS07695	COG4657	Part of a membrane complex involved in electron transport
C2U40_RS07700	COG0697	spore germination
C2U40_RS07720	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U40_RS07725	COG1288	antiporter activity
C2U40_RS07730	COG0436	Aminotransferase
C2U40_RS07740	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U40_RS07745	COG2027	D-alanyl-D-alanine carboxypeptidase
C2U40_RS07750	COG1061	Type III restriction enzyme res subunit
C2U40_RS07755	COG1566	PFAM secretion protein HlyD family protein
C2U40_RS07765	COG1966	Carbon starvation protein
C2U40_RS07770	COG3279	Response regulator of the LytR AlgR family
C2U40_RS07775	COG3275	phosphorelay sensor kinase activity
C2U40_RS07780	COG2199	diguanylate cyclase activity
C2U40_RS07780	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U40_RS07785	COG1012	belongs to the aldehyde dehydrogenase family
C2U40_RS07785	COG1454	alcohol dehydrogenase
C2U40_RS07795	COG2095	MarC family integral membrane protein
C2U40_RS07805	COG0601	transmembrane transport
C2U40_RS07810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U40_RS07825	COG0861	Integral membrane protein TerC family
C2U40_RS07835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U40_RS07845	COG1301	dicarboxylic acid transport
C2U40_RS07860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U40_RS07875	COG0537	adenosine 5'-monophosphoramidase activity
C2U40_RS07910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U40_RS07915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U40_RS07925	COG2354	Protein conserved in bacteria
C2U40_RS07940	COG2233	PERMEase
C2U40_RS07945	COG3150	esterase
C2U40_RS07950	COG1252	NADH dehydrogenase
C2U40_RS07970	COG0393	Putative heavy-metal-binding
C2U40_RS07980	COG4667	esterase of the alpha-beta hydrolase superfamily
C2U40_RS07985	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2U40_RS07990	COG1368	sulfuric ester hydrolase activity
C2U40_RS08000	COG0527	aspartate kinase activity
C2U40_RS08005	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U40_RS08005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U40_RS08010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U40_RS08035	COG0596	Alpha beta hydrolase
C2U40_RS08040	COG0346	lactoylglutathione lyase activity
C2U40_RS08050	COG0583	DNA-binding transcription factor activity
C2U40_RS08055	COG1620	l-lactate permease
C2U40_RS08065	COG1139	Iron-sulfur cluster binding protein
C2U40_RS08095	COG0577	efflux transmembrane transporter activity
C2U40_RS08100	COG1136	(ABC) transporter
C2U40_RS08110	COG2814	Major facilitator Superfamily
C2U40_RS08130	COG0672	)-iron permease
C2U40_RS08160	COG0659	secondary active sulfate transmembrane transporter activity
C2U40_RS08185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U40_RS08190	COG0840	transmembrane signaling receptor activity
C2U40_RS08200	COG2201	protein-glutamate methylesterase activity
C2U40_RS08210	COG0835	chemotaxis
C2U40_RS08215	COG0840	transmembrane signaling receptor activity
C2U40_RS08220	COG2198	Histidine kinase
C2U40_RS08220	COG0643	Histidine kinase
C2U40_RS08230	COG0745	RESPONSE REGULATOR receiver
C2U40_RS08235	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C2U40_RS08240	COG0437	4 iron, 4 sulfur cluster binding
C2U40_RS08245	COG5557	Pfam Polysulphide reductase, NrfD
C2U40_RS08250	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C2U40_RS08255	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2U40_RS08260	COG1773	rubredoxin
C2U40_RS08275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U40_RS08280	COG0444	Belongs to the ABC transporter superfamily
C2U40_RS08285	COG1126	abc transporter atp-binding protein
C2U40_RS08290	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2U40_RS08295	COG0375	protein maturation
C2U40_RS08300	COG0309	Hydrogenase expression formation protein (HypE)
C2U40_RS08310	COG0298	carbon dioxide binding
C2U40_RS08315	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C2U40_RS08325	COG1921	L-seryl-tRNASec selenium transferase activity
C2U40_RS08330	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2U40_RS08340	COG3260	NADH ubiquinone oxidoreductase 20
C2U40_RS08345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_RS08350	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2U40_RS08350	COG3261	NADH dehydrogenase
C2U40_RS08355	COG0650	Formate hydrogenlyase subunit 4
C2U40_RS08360	COG0651	ATP synthesis coupled electron transport
C2U40_RS08365	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U40_RS08370	COG3158	transport of potassium into the cell
C2U40_RS08380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U40_RS08405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U40_RS08415	COG0326	Molecular chaperone. Has ATPase activity
C2U40_RS08425	COG0563	adenylate kinase activity
C2U40_RS08430	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2U40_RS08440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U40_RS08455	COG3300	MHYT domain
C2U40_RS08455	COG5001	Diguanylate cyclase
C2U40_RS08480	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U40_RS08485	COG3433	isochorismatase activity
C2U40_RS08485	COG1535	isochorismatase
C2U40_RS08490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U40_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_RS08505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U40_RS08510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U40_RS08520	COG1120	ATPase activity
C2U40_RS08525	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U40_RS08530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U40_RS08535	COG4771	TonB-dependent receptor
C2U40_RS08575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2U40_RS08580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U40_RS08585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U40_RS08600	COG1570	exodeoxyribonuclease VII activity
C2U40_RS08605	COG0697	spore germination
C2U40_RS08625	COG3158	transport of potassium into the cell
C2U40_RS08630	COG0517	IMP dehydrogenase activity
C2U40_RS08630	COG0516	GMP reductase activity
C2U40_RS08635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U40_RS08635	COG0519	Catalyzes the synthesis of GMP from XMP
C2U40_RS08675	COG2062	phosphohistidine phosphatase, SixA
C2U40_RS08685	COG0697	spore germination
C2U40_RS08690	COG4166	transmembrane transport
C2U40_RS08695	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2U40_RS08700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U40_RS08710	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U40_RS08715	COG1136	(ABC) transporter
C2U40_RS08720	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U40_RS08725	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2U40_RS08740	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2U40_RS08745	COG0740	serine-type endopeptidase activity
C2U40_RS08750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2U40_RS08755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U40_RS08760	COG0776	regulation of translation
C2U40_RS08765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U40_RS08770	COG0488	(ABC) transporter
C2U40_RS08775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U40_RS08780	COG3162	membrane
C2U40_RS08795	COG1024	Enoyl-CoA hydratase
C2U40_RS08800	COG1115	amino acid carrier protein
C2U40_RS08815	COG1584	GPR1 FUN34 yaaH family protein
C2U40_RS08850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U40_RS08855	COG1960	acyl-CoA dehydrogenase activity
C2U40_RS08865	COG1960	acyl-CoA dehydrogenase activity
C2U40_RS08870	COG1024	Enoyl-CoA hydratase
C2U40_RS08875	COG1024	Enoyl-CoA hydratase
C2U40_RS08885	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_RS08895	COG0730	response to heat
C2U40_RS08935	COG0583	DNA-binding transcription factor activity
C2U40_RS08940	COG2723	6-phospho-beta-galactosidase activity
C2U40_RS08945	COG3300	MHYT domain
C2U40_RS08945	COG5001	Diguanylate cyclase
C2U40_RS08955	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U40_RS08965	COG0583	DNA-binding transcription factor activity
C2U40_RS08970	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2U40_RS08975	COG0673	inositol 2-dehydrogenase activity
C2U40_RS08980	COG0583	DNA-binding transcription factor activity
C2U40_RS08990	COG1560	Kdo2-lipid A biosynthetic process
C2U40_RS08995	COG1560	Kdo2-lipid A biosynthetic process
C2U40_RS09020	COG0417	DNA replication proofreading
C2U40_RS09050	COG0534	Mate efflux family protein
C2U40_RS09060	COG0307	riboflavin synthase, alpha
C2U40_RS09070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U40_RS09075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2U40_RS09080	COG0697	spore germination
C2U40_RS09085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U40_RS09125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U40_RS09130	COG3099	Belongs to the UPF0263 family
C2U40_RS09135	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2U40_RS09140	COG2894	cell division
C2U40_RS09145	COG0850	regulation of cytokinetic process
C2U40_RS09150	COG3100	YcgL domain-containing protein
C2U40_RS09155	COG2951	lytic endotransglycosylase activity
C2U40_RS09160	COG1760	l-serine dehydratase
C2U40_RS09170	COG1760	l-serine dehydratase
C2U40_RS09175	COG3123	guanosine phosphorylase activity
C2U40_RS09195	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2U40_RS09200	COG2067	long-chain fatty acid transport protein
C2U40_RS09205	COG2067	long-chain fatty acid transport protein
C2U40_RS09215	COG1595	DNA-templated transcription, initiation
C2U40_RS09245	COG0714	Associated with various cellular activities
C2U40_RS09250	COG0183	Belongs to the thiolase family
C2U40_RS09255	COG1024	Enoyl-CoA hydratase
C2U40_RS09255	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U40_RS09295	COG3829	transcription factor binding
C2U40_RS09300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U40_RS09305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U40_RS09310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U40_RS09320	COG0549	Belongs to the carbamate kinase family
C2U40_RS09325	COG0697	spore germination
C2U40_RS09330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2U40_RS09330	COG3608	succinylglutamate desuccinylase aspartoacylase
C2U40_RS09335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U40_RS09340	COG2068	MobA-Related Protein
C2U40_RS09355	COG4644	lycopene metabolic process
C2U40_RS09405	COG1309	transcriptional regulator
C2U40_RS09410	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_RS09425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U40_RS09430	COG0783	Belongs to the Dps family
C2U40_RS09450	COG0183	Belongs to the thiolase family
C2U40_RS09460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U40_RS09515	COG0625	glutathione transferase activity
C2U40_RS09520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U40_RS09530	COG0583	DNA-binding transcription factor activity
C2U40_RS09540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U40_RS09555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U40_RS09575	COG1846	Transcriptional regulator
C2U40_RS09580	COG0583	DNA-binding transcription factor activity
C2U40_RS09590	COG2948	multi-organism process
C2U40_RS09605	COG3846	protein secretion by the type IV secretion system
C2U40_RS09620	COG3451	type IV secretory pathway VirB4
C2U40_RS09635	COG4962	Type ii secretion system protein e
C2U40_RS09655	COG0741	lytic transglycosylase activity
C2U40_RS09675	COG0840	transmembrane signaling receptor activity
C2U40_RS09690	COG4644	lycopene metabolic process
C2U40_RS09700	COG0402	S-adenosylhomocysteine deaminase activity
C2U40_RS09705	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2U40_RS09710	COG2080	2 iron, 2 sulfur cluster binding
C2U40_RS09710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2U40_RS09715	COG2233	PERMEase
C2U40_RS09720	COG0402	S-adenosylhomocysteine deaminase activity
C2U40_RS09725	COG2252	PERMEase
C2U40_RS09730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2U40_RS09735	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2U40_RS09740	COG2080	2 iron, 2 sulfur cluster binding
C2U40_RS09750	COG3134	Outer membrane lipoprotein
C2U40_RS09760	COG1288	antiporter activity
C2U40_RS09765	COG0318	PFAM AMP-dependent synthetase and ligase
C2U40_RS09770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U40_RS09770	COG0140	phosphoribosyl-ATP diphosphatase activity
C2U40_RS09775	COG0107	imidazoleglycerol-phosphate synthase activity
C2U40_RS09780	COG0784	Response regulator, receiver
C2U40_RS09780	COG2198	Histidine kinase
C2U40_RS09780	COG2205	protein histidine kinase activity
C2U40_RS09785	COG2199	diguanylate cyclase activity
C2U40_RS09790	COG3437	response regulator, receiver
C2U40_RS09795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2U40_RS09800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U40_RS09805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U40_RS09805	COG0131	Imidazoleglycerol-phosphate dehydratase
C2U40_RS09810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U40_RS09815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U40_RS09820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U40_RS09830	COG1199	ATP-dependent helicase activity
C2U40_RS09840	COG1214	PFAM Peptidase M22, glycoprotease
C2U40_RS09850	COG0596	Alpha beta hydrolase
C2U40_RS09850	COG2226	methyltransferase
C2U40_RS09850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U40_RS09855	COG0318	PFAM AMP-dependent synthetase and ligase
C2U40_RS09860	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C2U40_RS09875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U40_RS09880	COG2832	Protein of unknown function (DUF454)
C2U40_RS09885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2U40_RS09890	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2U40_RS09895	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2U40_RS09910	COG0517	IMP dehydrogenase activity
C2U40_RS09910	COG0617	tRNA 3'-terminal CCA addition
C2U40_RS09910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2U40_RS09915	COG1643	Atp-dependent helicase
C2U40_RS09925	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2U40_RS09935	COG3437	response regulator, receiver
C2U40_RS09940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U40_RS09945	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2U40_RS09950	COG0709	Synthesizes selenophosphate from selenide and ATP
C2U40_RS09965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U40_RS09975	COG0840	transmembrane signaling receptor activity
C2U40_RS09980	COG1254	Belongs to the acylphosphatase family
C2U40_RS09985	COG0625	glutathione transferase activity
C2U40_RS09990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U40_RS09990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U40_RS09995	COG0489	protein tyrosine kinase activity
C2U40_RS10000	COG0572	uridine kinase
C2U40_RS10005	COG0717	Belongs to the dCTP deaminase family
C2U40_RS10010	COG0306	phosphate transporter
C2U40_RS10020	COG1530	ribonuclease E activity
C2U40_RS10025	COG0564	pseudouridine synthase activity
C2U40_RS10030	COG0546	phosphoglycolate phosphatase activity
C2U40_RS10035	COG0424	maF-like protein
C2U40_RS10040	COG2814	Major facilitator Superfamily
C2U40_RS10055	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U40_RS10060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2U40_RS10065	COG0416	fatty acid biosynthetic process
C2U40_RS10070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U40_RS10080	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_RS10085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U40_RS10095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U40_RS10100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U40_RS10105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2U40_RS10110	COG0470	DNA polymerase III
C2U40_RS10115	COG0084	hydrolase, TatD family'
C2U40_RS10135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U40_RS10135	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C2U40_RS10140	COG3008	intermembrane lipid transfer
C2U40_RS10145	COG2995	paraquat-inducible protein a
C2U40_RS10155	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2U40_RS10160	COG0372	Belongs to the citrate synthase family
C2U40_RS10205	COG4221	oxidoreductase activity
C2U40_RS10215	COG3141	response to X-ray
C2U40_RS10225	COG1067	ATP-dependent peptidase activity
C2U40_RS10230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U40_RS10245	COG0488	(ABC) transporter
C2U40_RS10255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U40_RS10255	COG0116	Belongs to the methyltransferase superfamily
C2U40_RS10265	COG0167	dihydroorotate dehydrogenase activity
C2U40_RS10270	COG2902	Dehydrogenase
C2U40_RS10280	COG0308	aminopeptidase N
C2U40_RS10290	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2U40_RS10295	COG1956	GAF domain-containing protein
C2U40_RS10305	COG3278	Belongs to the heme-copper respiratory oxidase family
C2U40_RS10320	COG2010	Cytochrome c
C2U40_RS10345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U40_RS10350	COG0589	response to stress
C2U40_RS10355	COG0037	tRNA processing
C2U40_RS10370	COG0625	glutathione transferase activity
C2U40_RS10375	COG1869	D-ribose catabolic process
C2U40_RS10380	COG1129	ABC transporter
C2U40_RS10385	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U40_RS10390	COG1879	ABC-type sugar transport system periplasmic component
C2U40_RS10395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U40_RS10400	COG1609	Transcriptional regulator
C2U40_RS10405	COG5001	Diguanylate cyclase
C2U40_RS10405	COG3300	MHYT domain
C2U40_RS10435	COG0776	regulation of translation
C2U40_RS10440	COG0072	phenylalanine-tRNA ligase activity
C2U40_RS10440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U40_RS10445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2U40_RS10450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2U40_RS10455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U40_RS10460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2U40_RS10465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2U40_RS10485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U40_RS10495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U40_RS10500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U40_RS10505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U40_RS10510	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2U40_RS10515	COG3313	Fe-S protein
C2U40_RS10520	COG2942	2-epimerase
C2U40_RS10525	COG3716	PTS system mannose fructose sorbose family IID component
C2U40_RS10530	COG3715	PTS system
C2U40_RS10535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_RS10535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_RS10550	COG1609	Transcriptional regulator
C2U40_RS10555	COG2140	Oxalate decarboxylase
C2U40_RS10560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_RS10560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_RS10560	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U40_RS10565	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U40_RS10570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_RS10570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_RS10575	COG1609	Transcriptional regulator
C2U40_RS10580	COG0814	amino acid
C2U40_RS10590	COG5654	RES domain protein
C2U40_RS10595	COG0513	Belongs to the DEAD box helicase family
C2U40_RS10605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2U40_RS10610	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U40_RS10615	COG2840	Smr protein MutS2
C2U40_RS10625	COG3706	GGDEF domain
C2U40_RS10630	COG0588	phosphoglycerate mutase activity
C2U40_RS10655	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U40_RS10725	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2U40_RS10730	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2U40_RS10740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U40_RS10745	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2U40_RS10755	COG0205	6-phosphofructokinase activity
C2U40_RS10760	COG1473	amidohydrolase
C2U40_RS10765	COG1011	Hydrolase
C2U40_RS10770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U40_RS10825	COG3593	DNA synthesis involved in DNA repair
C2U40_RS10840	COG0583	DNA-binding transcription factor activity
C2U40_RS10845	COG0730	response to heat
C2U40_RS10850	COG3148	PFAM DTW domain containing protein
C2U40_RS10860	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U40_RS10875	COG0386	Belongs to the glutathione peroxidase family
C2U40_RS10880	COG0513	Belongs to the DEAD box helicase family
C2U40_RS10885	COG0456	acetyltransferase
C2U40_RS10895	COG1742	UPF0060 membrane protein
C2U40_RS10925	COG2329	Antibiotic biosynthesis monooxygenase
C2U40_RS10930	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U40_RS10955	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U40_RS10965	COG2501	S4 domain
C2U40_RS10975	COG1132	(ABC) transporter
C2U40_RS10985	COG1132	(ABC) transporter
C2U40_RS10995	COG3118	belongs to the thioredoxin family
C2U40_RS11000	COG0471	metal ion transport
C2U40_RS11005	COG0058	SHG alpha-glucan phosphorylase activity
C2U40_RS11040	COG0814	amino acid
C2U40_RS11045	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2U40_RS11050	COG0514	ATP-dependent DNA helicase (RecQ)
C2U40_RS11055	COG2766	serine protein kinase
C2U40_RS11065	COG2719	SpoVR family
C2U40_RS11070	COG2186	Transcriptional regulator
C2U40_RS11075	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U40_RS11080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U40_RS11085	COG0586	Pfam SNARE associated Golgi protein
C2U40_RS11095	COG0556	nucleotide-excision repair
C2U40_RS11110	COG2985	domain, Protein
C2U40_RS11110	COG0569	domain protein
C2U40_RS11115	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U40_RS11135	COG4565	transcriptional regulatory protein
C2U40_RS11140	COG3290	protein histidine kinase activity
C2U40_RS11145	COG1846	Transcriptional regulator
C2U40_RS11145	COG1940	carbohydrate kinase activity
C2U40_RS11150	COG0840	transmembrane signaling receptor activity
C2U40_RS11155	COG3012	SEC-C Motif Domain Protein
C2U40_RS11160	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2U40_RS11165	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C2U40_RS11170	COG0247	lactate metabolic process
C2U40_RS11180	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C2U40_RS11185	COG0437	4 iron, 4 sulfur cluster binding
C2U40_RS11190	COG3301	Polysulphide reductase, NrfD
C2U40_RS11195	COG1138	Cytochrome C-type biogenesis protein
C2U40_RS11205	COG3088	subunit of a heme lyase
C2U40_RS11205	COG4235	cytochrome complex assembly
C2U40_RS11220	COG3033	Beta-eliminating lyase
C2U40_RS11230	COG3046	protein related to deoxyribodipyrimidine photolyase
C2U40_RS11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U40_RS11260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2U40_RS11275	COG4774	siderophore transport
C2U40_RS11280	COG4977	sequence-specific DNA binding
C2U40_RS11290	COG0583	DNA-binding transcription factor activity
C2U40_RS11295	COG2910	NAD(P)H-binding
C2U40_RS11310	COG0612	Peptidase, M16
C2U40_RS11315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U40_RS11325	COG1944	ATP diphosphatase activity
C2U40_RS11330	COG2116	formate transmembrane transporter activity
C2U40_RS11335	COG1882	Formate acetyltransferase
C2U40_RS11340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U40_RS11345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U40_RS11350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2U40_RS11360	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U40_RS11365	COG3842	ATPase activity
C2U40_RS11375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U40_RS11380	COG2983	Belongs to the UPF0260 family
C2U40_RS11385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U40_RS11390	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U40_RS11395	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U40_RS11400	COG0567	Dehydrogenase, E1 component
C2U40_RS11410	COG1053	succinate dehydrogenase
C2U40_RS11415	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U40_RS11440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U40_RS11445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U40_RS11445	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2U40_RS11455	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U40_RS11470	COG1451	nucleotide metabolic process
C2U40_RS11485	COG0254	rRNA binding
C2U40_RS11490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U40_RS11500	COG0583	DNA-binding transcription factor activity
C2U40_RS11510	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U40_RS11520	COG1879	ABC-type sugar transport system periplasmic component
C2U40_RS11525	COG1069	ribulokinase activity
C2U40_RS11535	COG2160	L-arabinose isomerase activity
C2U40_RS11540	COG2925	Exonuclease
C2U40_RS11550	COG3345	alpha-galactosidase
C2U40_RS11555	COG1380	Effector of murein hydrolase LrgA
C2U40_RS11560	COG1346	cytolysis
C2U40_RS11565	COG0295	cytidine deaminase activity
C2U40_RS11570	COG1022	Amp-dependent synthetase and ligase
C2U40_RS11585	COG0861	Integral membrane protein TerC family
C2U40_RS11590	COG2885	chlorophyll binding
C2U40_RS11595	COG2199	diguanylate cyclase activity
C2U40_RS11615	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2U40_RS11625	COG3768	UPF0283 membrane protein
C2U40_RS11630	COG3106	COG3106 Predicted ATPase
C2U40_RS11645	COG1842	Phage shock protein A
C2U40_RS11650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2U40_RS11660	COG4168	peptide transport system, permease
C2U40_RS11665	COG4171	peptide transport system, permease
C2U40_RS11675	COG4172	Belongs to the ABC transporter superfamily
C2U40_RS11685	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2U40_RS11690	COG1286	toxin biosynthetic process
C2U40_RS11695	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2U40_RS11705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U40_RS11710	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U40_RS11715	COG0531	amino acid
C2U40_RS11715	COG1674	ftsk spoiiie
C2U40_RS11725	COG0686	Belongs to the AlaDH PNT family
C2U40_RS11730	COG0492	ferredoxin-NADP+ reductase activity
C2U40_RS11740	COG3706	GGDEF domain
C2U40_RS11745	COG3134	Outer membrane lipoprotein
C2U40_RS11750	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U40_RS11755	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2U40_RS11760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U40_RS11765	COG0542	response to heat
C2U40_RS11770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U40_RS11775	COG1278	Cold shock
C2U40_RS11780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2U40_RS11840	COG3829	transcription factor binding
C2U40_RS11905	COG3209	COG3209 Rhs family protein
C2U40_RS11915	COG3501	Rhs element vgr protein
C2U40_RS11945	COG1435	thymidine kinase activity
C2U40_RS11950	COG1757	Na H antiporter
C2U40_RS11955	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U40_RS11960	COG2096	Adenosyltransferase
C2U40_RS11965	COG3530	Putative quorum-sensing-regulated virulence factor
C2U40_RS11970	COG0602	queuosine metabolic process
C2U40_RS11975	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U40_RS11995	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2U40_RS12005	COG0776	regulation of translation
C2U40_RS12010	COG0539	negative regulation of cytoplasmic translation
C2U40_RS12015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2U40_RS12020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U40_RS12030	COG0583	DNA-binding transcription factor activity
C2U40_RS12050	COG0778	Nitroreductase
C2U40_RS12055	COG5001	Diguanylate cyclase
C2U40_RS12055	COG3300	MHYT domain
C2U40_RS12065	COG0583	DNA-binding transcription factor activity
C2U40_RS12070	COG3437	response regulator, receiver
C2U40_RS12095	COG4989	oxidoreductase activity
C2U40_RS12100	COG0724	RNA recognition motif
C2U40_RS12120	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U40_RS12135	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U40_RS12140	COG1360	Flagellar Motor Protein
C2U40_RS12145	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_RS12150	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_RS12155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_RS12155	COG0649	NAD binding
C2U40_RS12170	COG1034	ATP synthesis coupled electron transport
C2U40_RS12175	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2U40_RS12180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_RS12185	COG0839	Belongs to the complex I subunit 6 family
C2U40_RS12190	COG0713	ATP synthesis coupled electron transport
C2U40_RS12200	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U40_RS12205	COG1007	ATP synthesis coupled electron transport
C2U40_RS12220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U40_RS12220	COG2199	diguanylate cyclase activity
C2U40_RS12225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U40_RS12225	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U40_RS12230	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U40_RS12240	COG1645	bacterial-type flagellum-dependent swarming motility
C2U40_RS12250	COG1160	GTP binding
C2U40_RS12255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U40_RS12260	COG2976	Protein conserved in bacteria
C2U40_RS12265	COG0124	histidyl-tRNA synthetase
C2U40_RS12270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2U40_RS12275	COG1426	Protein conserved in bacteria
C2U40_RS12285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U40_RS12290	COG0105	UTP biosynthetic process
C2U40_RS12305	COG0633	Ferredoxin
C2U40_RS12310	COG0443	Heat shock 70 kDa protein
C2U40_RS12315	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U40_RS12325	COG0822	iron-sulfur transferase activity
C2U40_RS12330	COG1104	cysteine desulfurase activity
C2U40_RS12350	COG3154	lipid carrier protein
C2U40_RS12355	COG0826	peptidase U32
C2U40_RS12360	COG0826	peptidase U32
C2U40_RS12375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U40_RS12380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U40_RS12385	COG1862	Preprotein translocase
C2U40_RS12390	COG0343	queuine tRNA-ribosyltransferase activity
C2U40_RS12395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2U40_RS12400	COG0517	IMP dehydrogenase activity
C2U40_RS12410	COG3634	alkyl hydroperoxide reductase activity
C2U40_RS12430	COG1393	Belongs to the ArsC family
C2U40_RS12435	COG0798	PFAM Bile acid sodium symporter
C2U40_RS12450	COG0640	Transcriptional regulator
C2U40_RS12465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U40_RS12465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U40_RS12470	COG0509	glycine decarboxylation via glycine cleavage system
C2U40_RS12475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U40_RS12480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U40_RS12485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U40_RS12505	COG2814	Major facilitator Superfamily
C2U40_RS12510	COG0625	glutathione transferase activity
C2U40_RS12550	COG0483	inositol monophosphate 1-phosphatase activity
C2U40_RS12570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U40_RS12635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U40_RS12635	COG0301	tRNA thio-modification
C2U40_RS12670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U40_RS12725	COG4953	penicillin-binding protein 1C
C2U40_RS12730	COG2373	Large extracellular alpha-helical protein
C2U40_RS12735	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U40_RS12745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U40_RS12765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_RS12775	COG2431	L-lysine efflux transmembrane transporter activity
C2U40_RS12780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U40_RS12785	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C2U40_RS12800	COG1393	Belongs to the ArsC family
C2U40_RS12810	COG4783	chaperone-mediated protein folding
C2U40_RS12815	COG0425	Belongs to the sulfur carrier protein TusA family
C2U40_RS12840	COG3842	ATPase activity
C2U40_RS12845	COG3833	ABC-type maltose transport systems, permease component
C2U40_RS12850	COG1175	transmembrane transport
C2U40_RS12860	COG3081	Nucleoid-associated protein
C2U40_RS12865	COG3082	Protein of unknown function (DUF1414)
C2U40_RS12870	COG3083	sulfuric ester hydrolase activity
C2U40_RS12875	COG4771	TonB-dependent receptor
C2U40_RS12880	COG1770	oligopeptidase
C2U40_RS12900	COG4574	serine-type endopeptidase inhibitor activity
C2U40_RS12905	COG3085	chromosome segregation
C2U40_RS12910	COG0583	DNA-binding transcription factor activity
C2U40_RS12915	COG0287	Prephenate dehydrogenase
C2U40_RS12915	COG1605	Chorismate mutase
C2U40_RS12920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U40_RS12925	COG0584	glycerophosphoryl diester phosphodiesterase
C2U40_RS12940	COG1349	DNA-binding transcription factor activity
C2U40_RS12945	COG2271	Major facilitator Superfamily
C2U40_RS12950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U40_RS12955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U40_RS12960	COG0583	DNA-binding transcription factor activity
C2U40_RS12985	COG0656	L-ascorbic acid biosynthetic process
C2U40_RS12990	COG2814	Major facilitator Superfamily
C2U40_RS13000	COG1294	oxidase, subunit
C2U40_RS13005	COG1271	oxidase subunit
C2U40_RS13010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U40_RS13015	COG2979	Protein of unknown function (DUF533)
C2U40_RS13040	COG2271	Major facilitator Superfamily
C2U40_RS13045	COG0583	DNA-binding transcription factor activity
C2U40_RS13055	COG2807	transmembrane transport
C2U40_RS13060	COG1187	pseudouridine synthase activity
C2U40_RS13080	COG0346	lactoylglutathione lyase activity
C2U40_RS13090	COG1403	HNH endonuclease
C2U40_RS13105	COG3681	Belongs to the UPF0597 family
C2U40_RS13115	COG0814	amino acid
C2U40_RS13135	COG1166	arginine decarboxylase activity
C2U40_RS13155	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U40_RS13185	COG0583	DNA-binding transcription factor activity
C2U40_RS13195	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C2U40_RS13200	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C2U40_RS13205	COG0840	transmembrane signaling receptor activity
C2U40_RS13210	COG0302	gtp cyclohydrolase
C2U40_RS13220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U40_RS13225	COG1448	Aminotransferase
C2U40_RS13250	COG1199	ATP-dependent helicase activity
C2U40_RS13260	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2U40_RS13265	COG0477	Major facilitator Superfamily
C2U40_RS13270	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2U40_RS13295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U40_RS13310	COG2271	Major facilitator Superfamily
C2U40_RS13320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_RS13325	COG0765	amino acid transport
C2U40_RS13330	COG1126	abc transporter atp-binding protein
C2U40_RS13345	COG0531	amino acid
C2U40_RS13360	COG1253	flavin adenine dinucleotide binding
C2U40_RS13365	COG0704	Plays a role in the regulation of phosphate uptake
C2U40_RS13370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2U40_RS13375	COG0581	inorganic phosphate transmembrane transporter activity
C2U40_RS13380	COG0573	inorganic phosphate transmembrane transporter activity
C2U40_RS13385	COG0590	tRNA wobble adenosine to inosine editing
C2U40_RS13395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U40_RS13415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2U40_RS13420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2U40_RS13425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U40_RS13430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U40_RS13455	COG2716	regulation of RNA biosynthetic process
C2U40_RS13460	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2U40_RS13480	COG0328	RNA-DNA hybrid ribonuclease activity
C2U40_RS13485	COG2226	methyltransferase
C2U40_RS13490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U40_RS13495	COG1388	LysM domain
C2U40_RS13495	COG0741	lytic transglycosylase activity
C2U40_RS13500	COG3385	transposase activity
C2U40_RS13505	COG3021	interspecies interaction between organisms
C2U40_RS13515	COG1607	acyl-coa hydrolase
C2U40_RS13530	COG0741	lytic transglycosylase activity
C2U40_RS13540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U40_RS13560	COG2911	Protein conserved in bacteria
C2U40_RS13565	COG0729	surface antigen
C2U40_RS13575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U40_RS13580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U40_RS13590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U40_RS13600	COG4134	Bacterial extracellular solute-binding protein
C2U40_RS13610	COG4136	ATPase activity
C2U40_RS13615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U40_RS13620	COG2951	lytic endotransglycosylase activity
C2U40_RS13635	COG1846	Transcriptional regulator
C2U40_RS13645	COG0033	Phosphoglucomutase
C2U40_RS13650	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C2U40_RS13655	COG0596	Alpha beta hydrolase
C2U40_RS13670	COG0716	FMN binding
C2U40_RS13680	COG0735	belongs to the Fur family
C2U40_RS13685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U40_RS13695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_RS13695	COG1263	PTS System
C2U40_RS13695	COG2190	(PTS) system
C2U40_RS13700	COG0363	glucosamine-6-phosphate deaminase activity
C2U40_RS13705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U40_RS13710	COG1846	Transcriptional regulator
C2U40_RS13710	COG1940	carbohydrate kinase activity
C2U40_RS13715	COG2194	sulfuric ester hydrolase activity
C2U40_RS13720	COG0217	transcriptional regulatory protein
C2U40_RS13725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2U40_RS13730	COG1801	Protein of unknown function DUF72
C2U40_RS13735	COG4106	trans-aconitate 2-methyltransferase activity
C2U40_RS13740	COG0500	methyltransferase
C2U40_RS13760	COG0450	alkyl hydroperoxide reductase
C2U40_RS13765	COG0583	DNA-binding transcription factor activity
C2U40_RS13775	COG0791	NLP P60 protein
C2U40_RS13790	COG1309	transcriptional regulator
C2U40_RS13830	COG0534	Mate efflux family protein
C2U40_RS13845	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2U40_RS13845	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2U40_RS13845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U40_RS13845	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2U40_RS13855	COG0633	Ferredoxin
C2U40_RS13855	COG3217	Mosc domain protein beta barrel domain protein
C2U40_RS13855	COG3217	Mosc domain protein beta barrel domain protein
C2U40_RS13855	COG0633	Ferredoxin
C2U40_RS13870	COG0501	Belongs to the peptidase M48B family
C2U40_RS13875	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2U40_RS13880	COG2226	methyltransferase
C2U40_RS13880	COG1073	alpha beta
C2U40_RS13885	COG0156	8-amino-7-oxononanoate synthase activity
C2U40_RS13890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U40_RS13910	COG0017	Asparaginyl-tRNA synthetase
C2U40_RS13915	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U40_RS13930	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U40_RS13940	COG0583	DNA-binding transcription factor activity
C2U40_RS13950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U40_RS13960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U40_RS13965	COG1393	Belongs to the ArsC family
C2U40_RS13970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U40_RS13975	COG1876	peptidase activity
C2U40_RS13985	COG3263	regulation of cellular component size
C2U40_RS14005	COG1280	lysine exporter protein (LysE YggA)
C2U40_RS14030	COG1957	nucleoside hydrolase
C2U40_RS14035	COG0564	pseudouridine synthase activity
C2U40_RS14045	COG1454	alcohol dehydrogenase
C2U40_RS14050	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U40_RS14055	COG0702	epimerase
C2U40_RS14060	COG2914	Belongs to the UPF0125 (RnfH) family
C2U40_RS14065	COG2867	negative regulation of translational initiation
C2U40_RS14070	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2U40_RS14080	COG0582	viral genome integration into host DNA
C2U40_RS14090	COG4983	Phage plasmid primase, P4 family domain protein
C2U40_RS14105	COG5377	YqaJ viral recombinase family
C2U40_RS14150	COG2003	Belongs to the UPF0758 family
C2U40_RS14205	COG3039	Transposase
C2U40_RS14220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U40_RS14245	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U40_RS14285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U40_RS14295	COG2814	Major facilitator Superfamily
C2U40_RS14295	COG0477	Major facilitator Superfamily
C2U40_RS14300	COG0457	Tetratricopeptide repeat
C2U40_RS14305	COG1940	carbohydrate kinase activity
C2U40_RS14310	COG0583	DNA-binding transcription factor activity
C2U40_RS14315	COG3048	D-serine ammonia-lyase activity
C2U40_RS14330	COG0538	isocitrate dehydrogenase activity
C2U40_RS14335	COG2207	Transcriptional regulator
C2U40_RS14355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_RS14370	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2U40_RS14375	COG1263	PTS System
C2U40_RS14375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_RS14380	COG1609	Transcriptional regulator
C2U40_RS14415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_RS14415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_RS14415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_RS14420	COG5599	Phosphatase
C2U40_RS14435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U40_RS14445	COG1187	pseudouridine synthase activity
C2U40_RS14455	COG0482	sulfurtransferase activity
C2U40_RS14460	COG2915	High frequency lysogenization protein hflD homolog
C2U40_RS14465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U40_RS14470	COG2850	peptidyl-arginine hydroxylation
C2U40_RS14480	COG3153	acetyltransferase
C2U40_RS14490	COG0625	glutathione transferase activity
C2U40_RS14495	COG0259	pyridoxamine-phosphate oxidase activity
C2U40_RS14510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U40_RS14510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U40_RS14515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U40_RS14530	COG4235	cytochrome complex assembly
C2U40_RS14530	COG3088	subunit of a heme lyase
C2U40_RS14535	COG3088	subunit of a heme lyase
C2U40_RS14535	COG4235	cytochrome complex assembly
C2U40_RS14540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U40_RS14545	COG1138	Cytochrome C-type biogenesis protein
C2U40_RS14550	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2U40_RS14555	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U40_RS14560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U40_RS14565	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U40_RS14580	COG0835	chemotaxis
C2U40_RS14590	COG1192	Involved in chromosome partitioning
C2U40_RS14595	COG1360	Flagellar Motor Protein
C2U40_RS14600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U40_RS14605	COG2201	protein-glutamate methylesterase activity
C2U40_RS14610	COG0643	Histidine kinase
C2U40_RS14610	COG0784	Response regulator, receiver
C2U40_RS14610	COG2198	Histidine kinase
C2U40_RS14615	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2U40_RS14640	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U40_RS14650	COG1684	flagellar biosynthetic protein fliR
C2U40_RS14705	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U40_RS14715	COG1677	Flagellar hook-basal body complex protein FliE
C2U40_RS14730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U40_RS14750	COG1737	Transcriptional regulator
C2U40_RS14755	COG0469	pyruvate kinase activity
C2U40_RS14770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U40_RS14775	COG1960	acyl-CoA dehydrogenase activity
C2U40_RS14785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2U40_RS14805	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U40_RS14820	COG1342	Belongs to the UPF0251 family
C2U40_RS14825	COG0602	queuosine metabolic process
C2U40_RS14830	COG0242	peptide deformylase activity
C2U40_RS14835	COG1484	DNA-dependent DNA replication
C2U40_RS14840	COG4584	PFAM Integrase catalytic
C2U40_RS14845	COG0242	peptide deformylase activity
C2U40_RS14905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U40_RS14915	COG1136	(ABC) transporter
C2U40_RS14970	COG0243	molybdopterin cofactor binding
C2U40_RS14975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U40_RS14980	COG0583	DNA-binding transcription factor activity
C2U40_RS14990	COG1388	LysM domain
C2U40_RS14990	COG1376	ErfK ybiS ycfS ynhG family protein
C2U40_RS15005	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C2U40_RS15010	COG0791	NLP P60 protein
C2U40_RS15015	COG2091	lysine biosynthetic process via aminoadipic acid
C2U40_RS15020	COG3118	belongs to the thioredoxin family
C2U40_RS15030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U40_RS15035	COG0788	formyltetrahydrofolate deformylase activity
C2U40_RS15045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U40_RS15065	COG0366	Alpha amylase catalytic
C2U40_RS15070	COG0739	heme binding
C2U40_RS15070	COG0741	lytic transglycosylase activity
C2U40_RS15070	COG1196	nuclear chromosome segregation
C2U40_RS15075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U40_RS15080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2U40_RS15090	COG0673	inositol 2-dehydrogenase activity
C2U40_RS15120	COG1032	radical SAM domain protein
C2U40_RS15130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U40_RS15135	COG1566	PFAM secretion protein HlyD family protein
C2U40_RS15145	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U40_RS15150	COG0733	neurotransmitter:sodium symporter activity
C2U40_RS15185	COG0281	malic enzyme
C2U40_RS15195	COG0534	Mate efflux family protein
C2U40_RS15210	COG2233	PERMEase
C2U40_RS15215	COG0095	Lipoate-protein ligase
C2U40_RS15220	COG1115	amino acid carrier protein
C2U40_RS15225	COG0019	diaminopimelate decarboxylase activity
C2U40_RS15235	COG0678	peroxiredoxin activity
C2U40_RS15245	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2U40_RS15265	COG1131	(ABC) transporter
C2U40_RS15275	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U40_RS15285	COG3142	Participates in the control of copper homeostasis
C2U40_RS15310	COG5002	protein histidine kinase activity
C2U40_RS15315	COG0745	RESPONSE REGULATOR receiver
C2U40_RS15320	COG0346	lactoylglutathione lyase activity
C2U40_RS15325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U40_RS15330	COG1960	acyl-CoA dehydrogenase activity
C2U40_RS15335	COG3284	Transcriptional regulator
C2U40_RS15350	COG0697	spore germination
C2U40_RS15360	COG4565	transcriptional regulatory protein
C2U40_RS15365	COG3290	protein histidine kinase activity
C2U40_RS15370	COG0281	malic enzyme
C2U40_RS15385	COG1846	Transcriptional regulator
C2U40_RS15390	COG1566	PFAM secretion protein HlyD family protein
C2U40_RS15420	COG0602	queuosine metabolic process
C2U40_RS15425	COG1328	CTP reductase activity
C2U40_RS15435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U40_RS15440	COG3115	cell septum assembly
C2U40_RS15445	COG1196	nuclear chromosome segregation
C2U40_RS15455	COG2860	membrane
C2U40_RS15465	COG3108	Peptidase M15
C2U40_RS15470	COG2989	Protein conserved in bacteria
C2U40_RS15485	COG0463	Glycosyl transferase, family 2
C2U40_RS15505	COG0366	Alpha amylase catalytic
C2U40_RS15540	COG3706	GGDEF domain
C2U40_RS15550	COG3590	peptidase
C2U40_RS15560	COG0488	(ABC) transporter
C2U40_RS15570	COG0531	amino acid
C2U40_RS15580	COG1234	tRNA 3'-trailer cleavage
C2U40_RS15585	COG0814	amino acid
C2U40_RS15600	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U40_RS15605	COG1982	Orn Lys Arg decarboxylase major
C2U40_RS15610	COG0531	amino acid
C2U40_RS15615	COG3710	Transcriptional regulator
C2U40_RS15620	COG0825	malonyl-CoA metabolic process
C2U40_RS15630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U40_RS15635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U40_RS15640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U40_RS15645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U40_RS15650	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U40_RS15665	COG0750	zinc metalloprotease
C2U40_RS15670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2U40_RS15675	COG0575	Belongs to the CDS family
C2U40_RS15680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2U40_RS15685	COG0233	cytoplasmic translational termination
C2U40_RS15690	COG0528	UMP kinase activity
C2U40_RS15695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2U40_RS15700	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U40_RS15705	COG0024	Methionine aminopeptidase
C2U40_RS15710	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2U40_RS15715	COG2171	N-acyltransferase activity
C2U40_RS15725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_RS15725	COG1263	PTS System
C2U40_RS15745	COG0564	pseudouridine synthase activity
C2U40_RS15750	COG3098	single-species biofilm formation
C2U40_RS15775	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C2U40_RS15785	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U40_RS15785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U40_RS15800	COG1611	Belongs to the LOG family
C2U40_RS15805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U40_RS15810	COG0473	3-isopropylmalate dehydrogenase activity
C2U40_RS15820	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C2U40_RS15825	COG2363	Small membrane protein
C2U40_RS15835	COG0583	DNA-binding transcription factor activity
C2U40_RS15840	COG0840	transmembrane signaling receptor activity
C2U40_RS15845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U40_RS15860	COG1477	protein flavinylation
C2U40_RS15865	COG2871	sodium ion transport
C2U40_RS15870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U40_RS15875	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U40_RS15880	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U40_RS15885	COG1805	sodium ion transport
C2U40_RS15890	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U40_RS15895	COG0271	Belongs to the BolA IbaG family
C2U40_RS15900	COG2813	Specifically methylates the guanine in position
C2U40_RS15910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U40_RS15920	COG2211	Major facilitator Superfamily
C2U40_RS15925	COG3248	Nucleoside-binding outer membrane protein
C2U40_RS15930	COG1666	GTP binding
C2U40_RS15935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2U40_RS15940	COG0693	protein deglycase activity
C2U40_RS15980	COG4104	PAAR repeat-containing protein
C2U40_RS16000	COG2771	luxR family
C2U40_RS16070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U40_RS16070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U40_RS16075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U40_RS16085	COG1151	hydroxylamine reductase activity
C2U40_RS16090	COG0783	Belongs to the Dps family
C2U40_RS16115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U40_RS16130	COG4221	oxidoreductase activity
C2U40_RS16140	COG0415	Belongs to the DNA photolyase family
C2U40_RS16380	COG2842	Transposition protein
C2U40_RS16405	COG3272	Protein of unknown function (DUF1722)
C2U40_RS16435	COG1605	Chorismate mutase
C2U40_RS16435	COG0077	Prephenate dehydratase
C2U40_RS16465	COG5377	YqaJ viral recombinase family
C2U40_RS16495	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2U40_RS16535	COG2003	Belongs to the UPF0758 family
C2U40_RS16575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2U40_RS16640	COG2133	pyrroloquinoline quinone binding
C2U40_RS16660	COG0300	oxidoreductase activity
C2U40_RS16685	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2U40_RS16700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U40_RS16720	COG0826	peptidase U32
C2U40_RS16725	COG1280	lysine exporter protein (LysE YggA)
C2U40_RS16735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U40_RS16740	COG0840	transmembrane signaling receptor activity
C2U40_RS16755	COG2198	Histidine kinase
C2U40_RS16755	COG0643	Histidine kinase
C2U40_RS16765	COG0835	chemotaxis
C2U40_RS16770	COG0840	transmembrane signaling receptor activity
C2U40_RS16780	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2U40_RS16785	COG2201	protein-glutamate methylesterase activity
C2U40_RS16790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U40_RS16820	COG2197	response regulator
C2U40_RS16830	COG3188	usher protein
C2U40_RS16845	COG2200	EAL domain
C2U40_RS16845	COG2199	diguanylate cyclase activity
C2U40_RS16845	COG2203	Gaf domain
C2U40_RS16850	COG0826	peptidase U32
C2U40_RS16855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U40_RS16865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U40_RS16885	COG2200	EAL domain
C2U40_RS16890	COG0737	Belongs to the 5'-nucleotidase family
C2U40_RS16910	COG2204	response regulator
C2U40_RS16915	COG3385	transposase activity
C2U40_RS16920	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U40_RS16935	COG3385	transposase activity
C2U40_RS16940	COG1047	Peptidyl-prolyl cis-trans
C2U40_RS16945	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U40_RS16955	COG0784	Response regulator, receiver
C2U40_RS16955	COG0835	chemotaxis
C2U40_RS16960	COG0429	hydrolase of the alpha beta-hydrolase fold
C2U40_RS16965	COG4251	negative regulation of phosphorylation
C2U40_RS16965	COG3706	GGDEF domain
C2U40_RS16965	COG2203	Gaf domain
C2U40_RS16965	COG5001	Diguanylate cyclase
C2U40_RS16970	COG3089	Belongs to the UPF0270 family
C2U40_RS16980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U40_RS16985	COG0463	Glycosyl transferase, family 2
C2U40_RS16990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U40_RS16990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2U40_RS16995	COG0726	polysaccharide deacetylase
C2U40_RS17000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U40_RS17005	COG2076	Multidrug Resistance protein
C2U40_RS17010	COG2076	Multidrug Resistance protein
C2U40_RS17015	COG3954	Phosphoribulokinase
C2U40_RS17030	COG1765	OsmC-like protein
C2U40_RS17040	COG2226	methyltransferase
C2U40_RS17045	COG3397	chitin binding
C2U40_RS17060	COG2202	Pas domain
C2U40_RS17060	COG2205	protein histidine kinase activity
C2U40_RS17070	COG3655	Transcriptional regulator
C2U40_RS17075	COG2814	Major facilitator Superfamily
C2U40_RS17085	COG4771	TonB-dependent receptor
C2U40_RS17105	COG0748	coenzyme F420 binding
C2U40_RS17110	COG3721	Heme iron utilization protein
C2U40_RS17120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U40_RS17145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2U40_RS17150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U40_RS17155	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2U40_RS17175	COG0741	lytic transglycosylase activity
C2U40_RS17180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U40_RS17200	COG0488	(ABC) transporter
C2U40_RS17210	COG2252	PERMEase
C2U40_RS17215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U40_RS17220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U40_RS17225	COG3178	'Phosphotransferase
C2U40_RS17230	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2U40_RS17240	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U40_RS17245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U40_RS17250	COG2967	ApaG domain
C2U40_RS17255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U40_RS17270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U40_RS17275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U40_RS17290	COG0318	PFAM AMP-dependent synthetase and ligase
C2U40_RS17295	COG3314	Sporulation integral membrane protein YlbJ
C2U40_RS17300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U40_RS17305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2U40_RS17310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2U40_RS17315	COG0142	geranyltranstransferase activity
C2U40_RS17320	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2U40_RS17325	COG0330	HflC and HflK could
C2U40_RS17330	COG0330	HflC and HflK could
C2U40_RS17335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U40_RS17340	COG1923	regulation of RNA biosynthetic process
C2U40_RS17345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2U40_RS17350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U40_RS17360	COG0802	atpase or kinase
C2U40_RS17365	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U40_RS17365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U40_RS17370	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2U40_RS17385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U40_RS17390	COG2011	ABC-type metal ion transport system permease component
C2U40_RS17395	COG1464	Belongs to the NlpA lipoprotein family
C2U40_RS17405	COG0840	transmembrane signaling receptor activity
C2U40_RS17430	COG5002	protein histidine kinase activity
C2U40_RS17430	COG2198	Histidine kinase
C2U40_RS17430	COG0784	Response regulator, receiver
C2U40_RS17450	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C2U40_RS17465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2U40_RS17470	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2U40_RS17480	COG2716	regulation of RNA biosynthetic process
C2U40_RS17485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U40_RS17490	COG3013	Belongs to the UPF0304 family
C2U40_RS17500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U40_RS17505	COG0280	phosphate acetyltransferase
C2U40_RS17505	COG0857	belongs to the CobB CobQ family
C2U40_RS17520	COG0028	Belongs to the TPP enzyme family
C2U40_RS17530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U40_RS17535	COG0671	phosphoesterase, PA-phosphatase related
C2U40_RS17545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U40_RS17550	COG0473	3-isopropylmalate dehydrogenase activity
C2U40_RS17555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2U40_RS17560	COG0066	3-isopropylmalate dehydratase activity
C2U40_RS17575	COG4143	(ABC) transporter
C2U40_RS17585	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C2U40_RS17590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2U40_RS17600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U40_RS17630	COG0316	Belongs to the HesB IscA family
C2U40_RS17640	COG0038	chloride channel
C2U40_RS17645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U40_RS17660	COG0671	phosphoesterase, PA-phosphatase related
C2U40_RS17675	COG0784	Response regulator, receiver
C2U40_RS17675	COG3437	response regulator, receiver
C2U40_RS17685	COG2076	Multidrug Resistance protein
C2U40_RS17695	COG0346	lactoylglutathione lyase activity
C2U40_RS17700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U40_RS17705	COG1643	Atp-dependent helicase
C2U40_RS17715	COG1489	DNA binding
C2U40_RS17720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U40_RS17725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U40_RS17740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2U40_RS17745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2U40_RS17765	COG1924	4 iron, 4 sulfur cluster binding
C2U40_RS17770	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C2U40_RS17775	COG0842	Transport permease protein
C2U40_RS17780	COG1131	(ABC) transporter
C2U40_RS17795	COG0163	prenyltransferase activity
C2U40_RS17800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U40_RS17805	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U40_RS17830	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2U40_RS17845	COG1136	(ABC) transporter
C2U40_RS17865	COG0840	transmembrane signaling receptor activity
C2U40_RS17885	COG0529	Catalyzes the synthesis of activated sulfate
C2U40_RS17890	COG3273	potassium ion transport
C2U40_RS17890	COG0471	metal ion transport
C2U40_RS17895	COG2895	sulfate adenylyltransferase (ATP) activity
C2U40_RS17900	COG0175	sulfate reduction
C2U40_RS17905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U40_RS17905	COG1648	precorrin-2 dehydrogenase activity
C2U40_RS17910	COG0330	HflC and HflK could
C2U40_RS17915	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U40_RS17920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U40_RS17920	COG0517	IMP dehydrogenase activity
C2U40_RS17925	COG0488	(ABC) transporter
C2U40_RS17935	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U40_RS17940	COG0583	DNA-binding transcription factor activity
C2U40_RS17985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U40_RS17995	COG0668	transmembrane transport
C2U40_RS18005	COG2731	YhcH YjgK YiaL family protein
C2U40_RS18015	COG2132	Multicopper oxidase
C2U40_RS18020	COG1794	racemase activity, acting on amino acids and derivatives
C2U40_RS18030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U40_RS18055	COG0733	neurotransmitter:sodium symporter activity
C2U40_RS18065	COG0733	neurotransmitter:sodium symporter activity
C2U40_RS18080	COG0561	phosphatase activity
C2U40_RS18110	COG1846	Transcriptional regulator
C2U40_RS18115	COG1764	response to oxidative stress
C2U40_RS18120	COG2130	NADP-dependent
C2U40_RS18125	COG1051	belongs to the nudix hydrolase family
C2U40_RS18145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2U40_RS18150	COG1640	4-alpha-glucanotransferase
C2U40_RS18155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U40_RS18160	COG0676	glucose-6-phosphate 1-epimerase activity
C2U40_RS18165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U40_RS18170	COG0840	transmembrane signaling receptor activity
C2U40_RS18245	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2U40_RS18250	COG2885	chlorophyll binding
C2U40_RS18255	COG0823	Involved in the tonB-independent uptake of proteins
C2U40_RS18270	COG0811	peptide transport
C2U40_RS18275	COG0824	Thioesterase
C2U40_RS18280	COG3790	cyd operon protein YbgE
C2U40_RS18285	COG4890	Cyd operon protein YbgT
C2U40_RS18290	COG1294	oxidase, subunit
C2U40_RS18295	COG1271	oxidase subunit
C2U40_RS18300	COG2255	four-way junction helicase activity
C2U40_RS18305	COG0632	four-way junction helicase activity
C2U40_RS18310	COG0840	transmembrane signaling receptor activity
C2U40_RS18315	COG0442	prolyl-tRNA aminoacylation
C2U40_RS18320	COG4221	oxidoreductase activity
C2U40_RS18335	COG1024	Enoyl-CoA hydratase
C2U40_RS18355	COG4166	transmembrane transport
C2U40_RS18370	COG1872	DUF167
C2U40_RS18375	COG0762	integral membrane protein
C2U40_RS18380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2U40_RS18385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U40_RS18400	COG3022	response to hydroperoxide
C2U40_RS18405	COG0513	Belongs to the DEAD box helicase family
C2U40_RS18410	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2U40_RS18435	COG0735	belongs to the Fur family
C2U40_RS18440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U40_RS18455	COG0776	regulation of translation
C2U40_RS18460	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2U40_RS18485	COG0560	Phosphoserine phosphatase
C2U40_RS18495	COG5002	protein histidine kinase activity
C2U40_RS18495	COG5001	Diguanylate cyclase
C2U40_RS18495	COG3447	MASE1 domain protein
C2U40_RS18500	COG0813	purine-nucleoside phosphorylase activity
C2U40_RS18505	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2U40_RS18510	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2U40_RS18515	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2U40_RS18525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U40_RS18530	COG0084	hydrolase, TatD family'
C2U40_RS18535	COG2165	general secretion pathway protein
C2U40_RS18545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U40_RS18550	COG0004	ammonium transporteR
C2U40_RS18555	COG4974	Belongs to the 'phage' integrase family
C2U40_RS18565	COG1396	sequence-specific DNA binding
C2U40_RS18645	COG4680	protein conserved in bacteria
C2U40_RS18650	COG5499	transcription regulator containing HTH domain
C2U40_RS18660	COG4695	Portal protein
C2U40_RS18715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U40_RS18795	COG0795	lipopolysaccharide-transporting ATPase activity
C2U40_RS18800	COG0795	lipopolysaccharide-transporting ATPase activity
C2U40_RS18805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U40_RS18810	COG2927	DNA polymerase III (CHI subunit)
C2U40_RS18815	COG0525	valine-tRNA ligase activity
C2U40_RS18820	COG1253	flavin adenine dinucleotide binding
C2U40_RS18825	COG0586	Pfam SNARE associated Golgi protein
C2U40_RS18830	COG1686	Belongs to the peptidase S11 family
C2U40_RS18865	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2U40_RS18870	COG0527	aspartate kinase activity
C2U40_RS18875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U40_RS18885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2U40_RS18890	COG1546	Belongs to the CinA family
C2U40_RS18900	COG5377	YqaJ viral recombinase family
C2U40_RS18920	COG2003	Belongs to the UPF0758 family
C2U40_RS18940	COG1160	GTP binding
C2U40_RS18955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U40_RS18975	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U40_RS19025	COG0582	viral genome integration into host DNA
C2U40_RS19030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2U40_RS19055	COG3068	Protein conserved in bacteria
C2U40_RS19065	COG0739	heme binding
C2U40_RS19085	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2U40_RS19090	COG1121	(ABC) transporter
C2U40_RS19095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U40_RS19100	COG0583	DNA-binding transcription factor activity
C2U40_RS19105	COG0697	spore germination
C2U40_RS19110	COG1573	uracil-dna glycosylase
C2U40_RS19115	COG2962	Rard protein
C2U40_RS19125	COG2827	Endonuclease containing a URI domain
C2U40_RS19140	COG1842	Phage shock protein A
C2U40_RS19145	COG0204	Acyl-transferase
C2U40_RS19165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U40_RS19210	COG1289	transmembrane transporter activity
C2U40_RS19215	COG1566	PFAM secretion protein HlyD family protein
C2U40_RS19230	COG1051	belongs to the nudix hydrolase family
C2U40_RS19235	COG3150	esterase
C2U40_RS19245	COG3151	Protein conserved in bacteria
C2U40_RS19250	COG0494	nUDIX hydrolase
C2U40_RS19255	COG1538	Outer membrane efflux protein
C2U40_RS19260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2U40_RS19260	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2U40_RS19265	COG1560	Kdo2-lipid A biosynthetic process
C2U40_RS19280	COG1392	Phosphate transport regulator
C2U40_RS19285	COG0306	phosphate transporter
C2U40_RS19290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U40_RS19320	COG0583	DNA-binding transcription factor activity
C2U40_RS19325	COG1380	Effector of murein hydrolase LrgA
C2U40_RS19330	COG1346	cytolysis
C2U40_RS19345	COG0617	tRNA 3'-terminal CCA addition
C2U40_RS19350	COG3409	Peptidoglycan-binding domain 1 protein
C2U40_RS19350	COG3267	Type II secretory pathway component ExeA
C2U40_RS19360	COG1194	a g-specific adenine glycosylase
C2U40_RS19365	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2U40_RS19375	COG3111	PFAM Bacterial OB fold (BOF) protein
C2U40_RS19380	COG3240	lipase activity
C2U40_RS19390	COG2885	chlorophyll binding
C2U40_RS19390	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U40_RS19395	COG3009	Protein conserved in bacteria
C2U40_RS19400	COG3008	intermembrane lipid transfer
C2U40_RS19400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U40_RS19405	COG2995	paraquat-inducible protein a
C2U40_RS19415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U40_RS19425	COG2203	Gaf domain
C2U40_RS19425	COG4251	negative regulation of phosphorylation
C2U40_RS19425	COG3706	GGDEF domain
C2U40_RS19425	COG5001	Diguanylate cyclase
C2U40_RS19430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U40_RS19435	COG2813	Specifically methylates the guanine in position
C2U40_RS19440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2U40_RS19445	COG0297	glycogen (starch) synthase activity
C2U40_RS19485	COG1757	Na H antiporter
C2U40_RS19490	COG0583	DNA-binding transcription factor activity
C2U40_RS19495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2U40_RS19500	COG3842	ATPase activity
C2U40_RS19505	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U40_RS19510	COG1177	transmembrane transport
C2U40_RS19515	COG1012	belongs to the aldehyde dehydrogenase family
C2U40_RS19580	COG5006	permease, DMT superfamily
C2U40_RS19585	COG1522	sequence-specific DNA binding
C2U40_RS19590	COG0110	maltose O-acetyltransferase activity
C2U40_RS19595	COG0366	Alpha amylase catalytic
C2U40_RS19600	COG1263	PTS System
C2U40_RS19600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U40_RS19620	COG0252	asparaginase activity
C2U40_RS19635	COG1803	Methylglyoxal synthase
C2U40_RS19660	COG1444	tRNA N-acetyltransferase activity
C2U40_RS19670	COG0784	Response regulator, receiver
C2U40_RS19670	COG0835	chemotaxis
C2U40_RS19675	COG3314	Sporulation integral membrane protein YlbJ
C2U40_RS19715	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2U40_RS19720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U40_RS19735	COG0477	Major facilitator Superfamily
C2U40_RS19740	COG0523	cobalamin synthesis protein
C2U40_RS19750	COG1280	lysine exporter protein (LysE YggA)
C2U40_RS19760	COG2200	EAL domain
C2U40_RS19765	COG1049	propionate catabolic process, 2-methylcitrate cycle
C2U40_RS19770	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U40_RS19775	COG0840	transmembrane signaling receptor activity
C2U40_RS19780	COG0840	transmembrane signaling receptor activity
C2U40_RS19790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U40_RS19795	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U40_RS19800	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U40_RS19805	COG2186	Transcriptional regulator
C2U40_RS19835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U40_RS19840	COG1459	type II secretion system
C2U40_RS19855	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2U40_RS19860	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2U40_RS19865	COG0494	nUDIX hydrolase
C2U40_RS19875	COG0653	protein targeting
C2U40_RS19885	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2U40_RS19890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U40_RS19895	COG0849	cell division
C2U40_RS19900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U40_RS19905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U40_RS19910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U40_RS19915	COG0772	Belongs to the SEDS family
C2U40_RS19920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2U40_RS19925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U40_RS19930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U40_RS19935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U40_RS19940	COG0768	penicillin binding
C2U40_RS19945	COG3116	cell division
C2U40_RS19950	COG0275	rRNA processing
C2U40_RS19955	COG2001	Belongs to the MraZ family
C2U40_RS19965	COG1388	LysM domain
C2U40_RS19965	COG0741	lytic transglycosylase activity
C2U40_RS19975	COG1360	Flagellar Motor Protein
C2U40_RS19980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U40_RS19985	COG1191	sigma factor activity
C2U40_RS20010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2U40_RS20015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U40_RS20030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U40_RS20035	COG1256	bacterial-type flagellum assembly
C2U40_RS20035	COG4786	Flagellar basal body rod
C2U40_RS20045	COG1706	bacterial-type flagellum-dependent cell motility
C2U40_RS20050	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U40_RS20055	COG4786	Flagellar basal body rod
C2U40_RS20065	COG1749	Flagellar hook protein flgE
C2U40_RS20080	COG1815	bacterial-type flagellum-dependent cell motility
C2U40_RS20115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U40_RS20125	COG1677	Flagellar hook-basal body complex protein FliE
C2U40_RS20175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2U40_RS20180	COG3107	peptidoglycan biosynthetic process
C2U40_RS20185	COG0792	nuclease activity
C2U40_RS20190	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U40_RS20195	COG2823	Periplasmic or secreted lipoprotein
C2U40_RS20205	COG2969	positive regulation of protein catabolic process
C2U40_RS20210	COG0625	glutathione transferase activity
C2U40_RS20215	COG2857	Cytochrome c1
C2U40_RS20220	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2U40_RS20225	COG0723	plastoquinol--plastocyanin reductase activity
C2U40_RS20230	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U40_RS20235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U40_RS20240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U40_RS20250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U40_RS20255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U40_RS20285	COG3964	amidohydrolase
C2U40_RS20300	COG3711	transcriptional antiterminator
C2U40_RS20300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_RS20305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_RS20310	COG1660	Displays ATPase and GTPase activities
C2U40_RS20315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U40_RS20325	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2U40_RS20330	COG1137	ATPase activity
C2U40_RS20335	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U40_RS20340	COG3117	lipopolysaccharide transmembrane transporter activity
C2U40_RS20345	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U40_RS20350	COG0517	IMP dehydrogenase activity
C2U40_RS20350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U40_RS20355	COG1127	ABC transporter
C2U40_RS20360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U40_RS20365	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U40_RS20370	COG2854	intermembrane phospholipid transfer
C2U40_RS20380	COG5007	Belongs to the BolA IbaG family
C2U40_RS20385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U40_RS20390	COG0312	modulator of DNA gyrase
C2U40_RS20395	COG3028	Belongs to the UPF0307 family
C2U40_RS20410	COG2926	Belongs to the UPF0265 family
C2U40_RS20445	COG1396	sequence-specific DNA binding
C2U40_RS20450	COG3135	benzoate transporter
C2U40_RS20480	COG3047	cAMP biosynthetic process
C2U40_RS20490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2U40_RS20495	COG2197	response regulator
C2U40_RS20500	COG0629	single-stranded DNA binding
C2U40_RS20525	COG1278	Cold shock
C2U40_RS20530	COG4771	TonB-dependent receptor
C2U40_RS20535	COG3706	GGDEF domain
C2U40_RS20535	COG5001	Diguanylate cyclase
C2U40_RS20535	COG4251	negative regulation of phosphorylation
C2U40_RS20535	COG2203	Gaf domain
C2U40_RS20585	COG0346	lactoylglutathione lyase activity
C2U40_RS20595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U40_RS20600	COG1074	ATP-dependent DNA helicase activity
C2U40_RS20605	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U40_RS20610	COG2259	Doxx family
C2U40_RS20615	COG1741	Belongs to the pirin family
C2U40_RS20625	COG0583	DNA-binding transcription factor activity
C2U40_RS20655	COG1175	transmembrane transport
C2U40_RS20665	COG3842	ATPase activity
C2U40_RS20675	COG2199	diguanylate cyclase activity
C2U40_RS20675	COG2203	Gaf domain
C2U40_RS20695	COG1247	-acetyltransferase
C2U40_RS20700	COG0753	catalase activity
C2U40_RS20725	COG0494	nUDIX hydrolase
C2U40_RS20730	COG0628	permease
C2U40_RS20755	COG2957	Belongs to the agmatine deiminase family
C2U40_RS20765	COG3284	Transcriptional regulator
C2U40_RS20780	COG1461	Dihydroxyacetone kinase
C2U40_RS20785	COG2376	Dihydroxyacetone kinase
C2U40_RS20790	COG2252	PERMEase
C2U40_RS20830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U40_RS20835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U40_RS20840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U40_RS20845	COG0049	tRNA binding
C2U40_RS20850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U40_RS20855	COG2168	tRNA wobble position uridine thiolation
C2U40_RS20860	COG2923	Belongs to the DsrF TusC family
C2U40_RS20865	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U40_RS20870	COG0251	oxidation-reduction process
C2U40_RS20875	COG2964	Protein conserved in bacteria
C2U40_RS20880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2U40_RS20885	COG0085	RNA polymerase activity
C2U40_RS20890	COG0222	ribosome binding
C2U40_RS20895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2U40_RS20900	COG0081	regulation of translation
C2U40_RS20905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2U40_RS20910	COG0250	Participates in transcription elongation, termination and antitermination
C2U40_RS20925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U40_RS20950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2U40_RS20955	COG0569	domain protein
C2U40_RS20960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U40_RS20980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U40_RS20985	COG3005	denitrification pathway
C2U40_RS20990	COG0243	molybdopterin cofactor binding
C2U40_RS21020	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C2U40_RS21040	COG2204	response regulator
C2U40_RS21050	COG2205	protein histidine kinase activity
C2U40_RS21075	COG5413	integral membrane protein
C2U40_RS21085	COG1522	sequence-specific DNA binding
C2U40_RS21090	COG2502	aspartate--ammonia ligase
C2U40_RS21100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U40_RS21105	COG0542	response to heat
C2U40_RS21115	COG0564	pseudouridine synthase activity
C2U40_RS21120	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U40_RS21125	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U40_RS21135	COG3681	Belongs to the UPF0597 family
C2U40_RS21145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2U40_RS21150	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U40_RS21155	COG1979	alcohol dehydrogenase
C2U40_RS21170	COG3423	Transcriptional regulator
C2U40_RS21180	COG2842	Transposition protein
C2U40_RS21410	COG3040	lipid binding
C2U40_RS21420	COG0688	phosphatidylethanolamine metabolic process
C2U40_RS21435	COG0540	Belongs to the ATCase OTCase family
C2U40_RS21440	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C2U40_RS21445	COG1438	arginine binding
C2U40_RS21450	COG1288	antiporter activity
C2U40_RS21455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U40_RS21500	COG3250	beta-galactosidase activity
C2U40_RS21505	COG1609	Transcriptional regulator
C2U40_RS21510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U40_RS21520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2U40_RS21525	COG2017	converts alpha-aldose to the beta-anomer
C2U40_RS21530	COG0667	Aldo Keto reductase
C2U40_RS21535	COG1968	undecaprenyl-diphosphatase activity
C2U40_RS21540	COG3806	Anti-sigma factor
C2U40_RS21545	COG1595	DNA-templated transcription, initiation
C2U40_RS21565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2U40_RS21570	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2U40_RS21575	COG0477	Major facilitator Superfamily
C2U40_RS21590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_RS21595	COG1131	(ABC) transporter
C2U40_RS21600	COG0842	Transport permease protein
C2U40_RS21605	COG0842	Transport permease protein
C2U40_RS21610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U40_RS21620	COG2116	formate transmembrane transporter activity
C2U40_RS21625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U40_RS21625	COG1648	precorrin-2 dehydrogenase activity
C2U40_RS21630	COG2239	Acts as a magnesium transporter
C2U40_RS21635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U40_RS21640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2U40_RS21650	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U40_RS21660	COG0514	ATP-dependent DNA helicase (RecQ)
C2U40_RS21665	COG2050	protein possibly involved in aromatic compounds catabolism
C2U40_RS21680	COG2258	MOSC domain
C2U40_RS21685	COG1177	transmembrane transport
C2U40_RS21690	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U40_RS21695	COG3842	ATPase activity
C2U40_RS21715	COG0174	glutamine synthetase
C2U40_RS21735	COG3045	CreA protein
C2U40_RS21740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U40_RS21745	COG0443	Heat shock 70 kDa protein
C2U40_RS21760	COG0366	Alpha amylase catalytic
C2U40_RS21765	COG1086	Polysaccharide biosynthesis protein
C2U40_RS21770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U40_RS21775	COG4750	Nucleotidyl transferase
C2U40_RS21780	COG0519	Catalyzes the synthesis of GMP from XMP
C2U40_RS21785	COG0574	Belongs to the PEP-utilizing enzyme family
C2U40_RS21785	COG3848	Pyruvate phosphate dikinase
C2U40_RS21795	COG0529	Catalyzes the synthesis of activated sulfate
C2U40_RS21820	COG1215	transferase activity, transferring glycosyl groups
C2U40_RS21835	COG0318	PFAM AMP-dependent synthetase and ligase
C2U40_RS21840	COG1028	Short-chain dehydrogenase reductase Sdr
C2U40_RS21855	COG1083	cytidylyl-transferase
C2U40_RS21865	COG2089	acid synthase
C2U40_RS21885	COG4310	Domain of unknown function (DUF2172)
C2U40_RS21920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U40_RS21925	COG0745	RESPONSE REGULATOR receiver
C2U40_RS21930	COG2205	protein histidine kinase activity
C2U40_RS21940	COG0281	malic enzyme
C2U40_RS21945	COG0702	epimerase
C2U40_RS21950	COG0254	rRNA binding
C2U40_RS21955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U40_RS21975	COG0129	dihydroxy-acid dehydratase activity
C2U40_RS21985	COG3978	acetolactate synthase activity
C2U40_RS22000	COG0606	chelatase, subunit chli
C2U40_RS22005	COG0204	Acyl-transferase
C2U40_RS22010	COG0204	Acyl-transferase
C2U40_RS22015	COG1683	Conserved Protein
C2U40_RS22025	COG1335	isochorismatase
C2U40_RS22035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U40_RS22040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U40_RS22050	COG3084	Protein conserved in bacteria
C2U40_RS22055	COG5001	Diguanylate cyclase
C2U40_RS22055	COG4251	negative regulation of phosphorylation
C2U40_RS22055	COG3706	GGDEF domain
C2U40_RS22055	COG2203	Gaf domain
C2U40_RS22060	COG0789	Transcriptional regulator
C2U40_RS22070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2U40_RS22075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2U40_RS22080	COG1561	YicC-like family, N-terminal region
C2U40_RS22100	COG3306	glycosyltransferase involved in LPS biosynthesis
C2U40_RS22115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U40_RS22125	COG0156	8-amino-7-oxononanoate synthase activity
C2U40_RS22130	COG1063	alcohol dehydrogenase
C2U40_RS22135	COG3245	cytochrome
C2U40_RS22145	COG0210	DNA helicase
C2U40_RS22150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U40_RS22155	COG2166	iron-sulfur cluster assembly
C2U40_RS22160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U40_RS22190	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2U40_RS22195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U40_RS22200	COG1739	Uncharacterized protein family UPF0029
C2U40_RS22205	COG0006	proline dipeptidase activity
C2U40_RS22210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U40_RS22215	COG1024	Enoyl-CoA hydratase
C2U40_RS22215	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U40_RS22220	COG0183	Belongs to the thiolase family
C2U40_RS22245	COG0425	Belongs to the sulfur carrier protein TusA family
C2U40_RS22250	COG0251	oxidation-reduction process
C2U40_RS22255	COG2885	chlorophyll binding
C2U40_RS22265	COG2818	Glycosylase
C2U40_RS22270	COG0752	glycyl-tRNA synthetase alpha subunit
C2U40_RS22275	COG0751	glycine-tRNA ligase activity
C2U40_RS22320	COG3385	transposase activity
C2U40_RS22330	COG0814	amino acid
C2U40_RS22335	COG0348	domain, Protein
C2U40_RS22345	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U40_RS22350	COG1773	rubredoxin
C2U40_RS22350	COG0426	domain, Protein
C2U40_RS22355	COG3604	Transcriptional regulator
C2U40_RS22360	COG2188	Transcriptional regulator
C2U40_RS22375	COG1609	Transcriptional regulator
C2U40_RS22415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U40_RS22440	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U40_RS22455	COG3118	belongs to the thioredoxin family
C2U40_RS22460	COG0513	Belongs to the DEAD box helicase family
C2U40_RS22465	COG0248	Ppx GppA phosphatase
C2U40_RS22480	COG0742	ribosomal rna small subunit methyltransferase
C2U40_RS22500	COG0084	hydrolase, TatD family'
C2U40_RS22505	COG0805	protein transport
C2U40_RS22510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U40_RS22520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U40_RS22525	COG3165	ubiquinone biosynthetic process from chorismate
C2U40_RS22535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2U40_RS22540	COG0402	S-adenosylhomocysteine deaminase activity
C2U40_RS22580	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2U40_RS22585	COG0848	biopolymer transport protein
C2U40_RS22590	COG0811	peptide transport
C2U40_RS22595	COG0811	peptide transport
C2U40_RS22605	COG2771	luxR family
C2U40_RS22610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U40_RS22630	COG0732	type I restriction modification DNA specificity domain
C2U40_RS22635	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2U40_RS22670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U40_RS22675	COG1349	DNA-binding transcription factor activity
C2U40_RS22680	COG0745	RESPONSE REGULATOR receiver
C2U40_RS22685	COG2205	protein histidine kinase activity
C2U40_RS22695	COG4452	Inner membrane protein CreD
C2U40_RS22700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2U40_RS22705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2U40_RS22710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2U40_RS22715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2U40_RS22720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U40_RS22725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2U40_RS22730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2U40_RS22740	COG0356	it plays a direct role in the translocation of protons across the membrane
C2U40_RS22750	COG1475	DNA binding
C2U40_RS22755	COG1192	Involved in chromosome partitioning
C2U40_RS22760	COG0357	Ribosomal RNA small subunit methyltransferase G
C2U40_RS22765	COG0445	tRNA wobble uridine modification
C2U40_RS22770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U40_RS22775	COG4774	siderophore transport
C2U40_RS22780	COG4615	Cyclic peptide transporter
C2U40_RS22785	COG1120	ATPase activity
C2U40_RS22805	COG3550	peptidyl-serine autophosphorylation
C2U40_RS22830	COG4584	PFAM Integrase catalytic
C2U40_RS22835	COG1484	DNA-dependent DNA replication
C2U40_RS22865	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C2U40_RS22865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U40_RS22900	COG4974	Belongs to the 'phage' integrase family
C2U40_RS22905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2U40_RS22910	COG0706	membrane insertase activity
C2U40_RS22915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2U40_RS22920	COG0594	ribonuclease P activity
C2U40_RS22925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2U40_RS22930	COG1126	abc transporter atp-binding protein
C2U40_RS22945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2U40_RS22950	COG0592	DNA-directed DNA polymerase activity
C2U40_RS22975	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U40_RS22980	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U40_RS22985	COG3977	Valine--pyruvate aminotransferase
C2U40_RS23000	COG2814	Major facilitator Superfamily
C2U40_RS23005	COG0745	RESPONSE REGULATOR receiver
C2U40_RS23010	COG2205	protein histidine kinase activity
C2U40_RS23035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U40_RS23040	COG4191	Histidine kinase
C2U40_RS23040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_RS23045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U40_RS23050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U40_RS23085	COG0561	phosphatase activity
C2U40_RS23090	COG2267	carboxylic ester hydrolase activity
C2U40_RS23095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U40_RS23100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U40_RS23105	COG1758	RNA polymerase activity
C2U40_RS23115	COG0859	PFAM glycosyl transferase family 9
C2U40_RS23120	COG3642	lipopolysaccharide core region biosynthetic process
C2U40_RS23160	COG0589	response to stress
C2U40_RS23165	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U40_RS23175	COG1528	Iron-storage protein
C2U40_RS23180	COG2081	HI0933 family
C2U40_RS23185	COG2223	nitrite transmembrane transporter activity
C2U40_RS23205	COG3188	usher protein
C2U40_RS23225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U40_RS23225	COG2205	protein histidine kinase activity
C2U40_RS23235	COG3275	phosphorelay sensor kinase activity
C2U40_RS23240	COG3279	Response regulator of the LytR AlgR family
C2U40_RS23245	COG2223	nitrite transmembrane transporter activity
C2U40_RS23250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U40_RS23255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2U40_RS23270	COG0583	DNA-binding transcription factor activity
C2U40_RS23275	COG4206	TonB-dependent receptor
C2U40_RS23280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2U40_RS23310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U40_RS23310	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U40_RS23310	COG1042	CoA-binding domain protein
C2U40_RS23325	COG0583	DNA-binding transcription factor activity
C2U40_RS23330	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U40_RS23335	COG0166	Belongs to the GPI family
C2U40_RS23350	COG0668	transmembrane transport
C2U40_RS23355	COG1309	transcriptional regulator
C2U40_RS23360	COG0756	dUTP diphosphatase activity
C2U40_RS23365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U40_RS23370	COG2003	Belongs to the UPF0758 family
C2U40_RS23375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2U40_RS23380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2U40_RS23390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2U40_RS23395	COG2990	Protein conserved in bacteria
C2U40_RS23400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2U40_RS23405	COG0859	PFAM glycosyl transferase family 9
C2U40_RS23410	COG0463	Glycosyl transferase, family 2
C2U40_RS23415	COG0859	PFAM glycosyl transferase family 9
C2U40_RS23420	COG1519	Transferase
C2U40_RS23440	COG1609	Transcriptional regulator
C2U40_RS23445	COG0604	alcohol dehydrogenase
C2U40_RS23465	COG1580	Controls the rotational direction of flagella during chemotaxis
C2U40_RS23470	COG3161	chorismate lyase activity
C2U40_RS23475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2U40_RS23480	COG2937	Belongs to the GPAT DAPAT family
C2U40_RS23485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U40_RS23510	COG0534	Mate efflux family protein
C2U40_RS23515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U40_RS23520	COG2205	protein histidine kinase activity
C2U40_RS23525	COG0745	RESPONSE REGULATOR receiver
C2U40_RS23535	COG1045	serine acetyltransferase
C2U40_RS23545	COG3074	FtsZ-dependent cytokinesis
C2U40_RS23550	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2U40_RS23560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U40_RS23560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U40_RS23565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U40_RS23605	COG1609	Transcriptional regulator
C2U40_RS23610	COG3250	beta-galactosidase activity
C2U40_RS23615	COG2731	YhcH YjgK YiaL family protein
C2U40_RS23620	COG0531	amino acid
C2U40_RS23625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U40_RS23630	COG0531	amino acid
C2U40_RS23635	COG0385	Bile acid
C2U40_RS23640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U40_RS23660	COG0583	DNA-binding transcription factor activity
C2U40_RS23665	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2U40_RS23670	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2U40_RS23675	COG3845	ABC transporter
C2U40_RS23680	COG1744	ABC transporter substrate-binding protein PnrA-like
C2U40_RS23685	COG0210	DNA helicase
C2U40_RS23695	COG1943	Transposase
C2U40_RS23700	COG0583	DNA-binding transcription factor activity
C2U40_RS23755	COG1280	lysine exporter protein (LysE YggA)
C2U40_RS23765	COG2391	methyltransferase activity
C2U40_RS23770	COG0840	transmembrane signaling receptor activity
C2U40_RS23780	COG1280	lysine exporter protein (LysE YggA)
C2U40_RS23790	COG2962	Rard protein
C2U40_RS23800	COG1012	belongs to the aldehyde dehydrogenase family
C2U40_RS23805	COG1396	sequence-specific DNA binding
C2U40_RS23810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2U40_RS23820	COG0519	Catalyzes the synthesis of GMP from XMP
C2U40_RS23820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U40_RS23825	COG0686	Belongs to the AlaDH PNT family
C2U40_RS23830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U40_RS23850	COG1322	Protein conserved in bacteria
C2U40_RS23855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U40_RS23860	COG0569	domain protein
C2U40_RS23865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U40_RS23865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U40_RS23870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2U40_RS23875	COG0242	peptide deformylase activity
C2U40_RS23885	COG0758	DNA mediated transformation
C2U40_RS23890	COG2922	Belongs to the Smg family
C2U40_RS23895	COG0551	DNA topoisomerase type I activity
C2U40_RS23905	COG0009	L-threonylcarbamoyladenylate synthase
C2U40_RS23910	COG0408	coproporphyrinogen oxidase activity
C2U40_RS23915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U40_RS23925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2U40_RS23940	COG3078	GTPase activator activity
C2U40_RS23950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U40_RS23955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U40_RS23960	COG2204	response regulator
C2U40_RS23965	COG3852	Histidine kinase
C2U40_RS23975	COG0174	glutamine synthetase
C2U40_RS23980	COG1217	gtp-binding protein TYPA
C2U40_RS23990	COG1295	ribonuclease BN
C2U40_RS23995	COG1490	D-aminoacyl-tRNA deacylase activity
C2U40_RS24005	COG0456	acetyltransferase
C2U40_RS24015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U40_RS24020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U40_RS24025	COG2610	gluconate transmembrane transporter activity
C2U40_RS24030	COG3265	gluconokinase activity
C2U40_RS24035	COG0129	dihydroxy-acid dehydratase activity
C2U40_RS24040	COG0800	Aldolase
C2U40_RS24045	COG1609	Transcriptional regulator
C2U40_RS24055	COG4942	peptidase
C2U40_RS24060	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2U40_RS24065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U40_RS24070	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2U40_RS24075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2U40_RS24080	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2U40_RS24080	COG0316	Belongs to the HesB IscA family
C2U40_RS24085	COG1040	competence protein
C2U40_RS24090	COG0596	Alpha beta hydrolase
C2U40_RS24110	COG2183	response to ionizing radiation
C2U40_RS24115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U40_RS24135	COG0051	transcription antitermination factor activity, RNA binding
C2U40_RS24140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U40_RS24145	COG0088	Forms part of the polypeptide exit tunnel
C2U40_RS24150	COG0089	rRNA binding
C2U40_RS24155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2U40_RS24160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2U40_RS24165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2U40_RS24170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2U40_RS24175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2U40_RS24180	COG0255	Belongs to the universal ribosomal protein uL29 family
C2U40_RS24185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2U40_RS24190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2U40_RS24195	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2U40_RS24200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2U40_RS24205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2U40_RS24210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2U40_RS24215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2U40_RS24220	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2U40_RS24225	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2U40_RS24230	COG1841	ribosomal large subunit assembly
C2U40_RS24235	COG0200	Binds to the 23S rRNA
C2U40_RS24240	COG0201	protein transport
C2U40_RS24245	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U40_RS24250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2U40_RS24255	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2U40_RS24260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2U40_RS24265	COG0202	RNA polymerase activity
C2U40_RS24270	COG0203	ribosomal protein L17
C2U40_RS24330	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U40_RS24335	COG0583	DNA-binding transcription factor activity
C2U40_RS24340	COG4221	oxidoreductase activity
C2U40_RS24355	COG1770	oligopeptidase
C2U40_RS24380	COG3714	YhhN family
C2U40_RS24405	COG1301	dicarboxylic acid transport
C2U40_RS24415	COG2095	MarC family integral membrane protein
C2U40_RS24425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U40_RS24435	COG0741	lytic transglycosylase activity
C2U40_RS24440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U40_RS24470	COG0742	ribosomal rna small subunit methyltransferase
C2U40_RS24475	COG0552	protein localization to endoplasmic reticulum
C2U40_RS24480	COG2884	Cell division ATP-binding protein ftsE
C2U40_RS24485	COG2177	Part of the ABC transporter FtsEX involved in
C2U40_RS24495	COG0288	reversible hydration of carbon dioxide
C2U40_RS24500	COG2188	Transcriptional regulator
C2U40_RS24505	COG1228	amidohydrolase
C2U40_RS24510	COG0010	Belongs to the arginase family
C2U40_RS24515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2U40_RS24520	COG2986	histidine ammonia-lyase
C2U40_RS24525	COG0387	Pfam Sodium calcium exchanger
C2U40_RS24530	COG2200	EAL domain
C2U40_RS24535	COG2200	EAL domain
C2U40_RS24535	COG2199	diguanylate cyclase activity
C2U40_RS24710	COG2176	DNA-directed DNA polymerase activity
C2U40_RS24710	COG5002	protein histidine kinase activity
C2U40_RS24810	COG3385	transposase activity
C2U40_RS24830	COG1192	Involved in chromosome partitioning
C2U40_RS24835	COG3077	Addiction module antitoxin, RelB DinJ family
C2U40_RS24840	COG2026	Addiction module toxin, RelE StbE family
C2U40_RS24955	COG2176	DNA-directed DNA polymerase activity
C2U40_RS24955	COG5002	protein histidine kinase activity
C2U40_RS25025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U40_RS25055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U40_RS25070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U40_RS25110	COG1192	Involved in chromosome partitioning
C2U40_RS25125	COG0840	transmembrane signaling receptor activity
C2U40_RS25205	COG0840	transmembrane signaling receptor activity
C2U40_RS25240	COG3385	transposase activity
C2U40_RS25460	COG0592	DNA-directed DNA polymerase activity
C2U40_RS25870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U40_RS25885	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs