locus-tag	class	description
C2U47_RS00005	COG3300	MHYT domain
C2U47_RS00005	COG5001	Diguanylate cyclase
C2U47_RS00015	COG0583	DNA-binding transcription factor activity
C2U47_RS00020	COG0745	RESPONSE REGULATOR receiver
C2U47_RS00045	COG4989	oxidoreductase activity
C2U47_RS00050	COG0724	RNA recognition motif
C2U47_RS00060	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C2U47_RS00070	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2U47_RS00135	COG1002	Type II restriction enzyme, methylase subunits
C2U47_RS00140	COG1061	Type III restriction enzyme res subunit
C2U47_RS00150	COG4584	PFAM Integrase catalytic
C2U47_RS00155	COG1484	DNA-dependent DNA replication
C2U47_RS00170	COG5642	Protein of unknown function (DUF2384)
C2U47_RS00185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U47_RS00190	COG1360	Flagellar Motor Protein
C2U47_RS00195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U47_RS00200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U47_RS00220	COG1034	ATP synthesis coupled electron transport
C2U47_RS00225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2U47_RS00230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U47_RS00235	COG0839	Belongs to the complex I subunit 6 family
C2U47_RS00240	COG0713	ATP synthesis coupled electron transport
C2U47_RS00250	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U47_RS00255	COG1007	ATP synthesis coupled electron transport
C2U47_RS00260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U47_RS00260	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U47_RS00265	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U47_RS00275	COG1645	bacterial-type flagellum-dependent swarming motility
C2U47_RS00280	COG1160	GTP binding
C2U47_RS00285	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U47_RS00290	COG2976	Protein conserved in bacteria
C2U47_RS00295	COG0124	histidyl-tRNA synthetase
C2U47_RS00305	COG1426	Protein conserved in bacteria
C2U47_RS00315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U47_RS00320	COG0105	UTP biosynthetic process
C2U47_RS00335	COG0633	Ferredoxin
C2U47_RS00340	COG0443	Heat shock 70 kDa protein
C2U47_RS00355	COG0822	iron-sulfur transferase activity
C2U47_RS00360	COG1104	cysteine desulfurase activity
C2U47_RS00375	COG3154	lipid carrier protein
C2U47_RS00380	COG0826	peptidase U32
C2U47_RS00385	COG0826	peptidase U32
C2U47_RS00395	COG2897	thiosulfate sulfurtransferase activity
C2U47_RS00400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U47_RS00405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U47_RS00410	COG1862	Preprotein translocase
C2U47_RS00415	COG0343	queuine tRNA-ribosyltransferase activity
C2U47_RS00420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2U47_RS00425	COG0517	IMP dehydrogenase activity
C2U47_RS00430	COG0450	alkyl hydroperoxide reductase
C2U47_RS00435	COG3634	alkyl hydroperoxide reductase activity
C2U47_RS00475	COG5642	Protein of unknown function (DUF2384)
C2U47_RS00500	COG3385	transposase activity
C2U47_RS00520	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U47_RS00535	COG3012	SEC-C Motif Domain Protein
C2U47_RS00535	COG3318	Belongs to the UPF0149 family
C2U47_RS00555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U47_RS00555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U47_RS00560	COG0509	glycine decarboxylation via glycine cleavage system
C2U47_RS00565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U47_RS00570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U47_RS00575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U47_RS00595	COG2814	Major facilitator Superfamily
C2U47_RS00600	COG0444	Belongs to the ABC transporter superfamily
C2U47_RS00605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U47_RS00610	COG0601	transmembrane transport
C2U47_RS00620	COG0625	glutathione transferase activity
C2U47_RS00625	COG0625	glutathione transferase activity
C2U47_RS00635	COG0483	inositol monophosphate 1-phosphatase activity
C2U47_RS00650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U47_RS00655	COG2056	Na+-H+ antiporter family
C2U47_RS00660	COG2814	Major facilitator Superfamily
C2U47_RS00665	COG0583	DNA-binding transcription factor activity
C2U47_RS00670	COG5001	Diguanylate cyclase
C2U47_RS00685	COG2050	protein possibly involved in aromatic compounds catabolism
C2U47_RS00695	COG0247	lactate metabolic process
C2U47_RS00695	COG0277	FAD linked oxidase domain protein
C2U47_RS00710	COG1253	flavin adenine dinucleotide binding
C2U47_RS00715	COG1902	pentaerythritol trinitrate reductase activity
C2U47_RS00725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U47_RS00730	COG0647	UMP catabolic process
C2U47_RS00740	COG0367	asparagine synthase
C2U47_RS00755	COG0625	glutathione transferase activity
C2U47_RS00765	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C2U47_RS00780	COG0564	pseudouridine synthase activity
C2U47_RS00785	COG5001	Diguanylate cyclase
C2U47_RS00790	COG0840	transmembrane signaling receptor activity
C2U47_RS00795	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2U47_RS00830	COG0670	Belongs to the BI1 family
C2U47_RS00835	COG1289	transmembrane transporter activity
C2U47_RS00840	COG2920	part of a sulfur-relay system
C2U47_RS00845	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C2U47_RS00850	COG0285	dihydrofolate synthase activity
C2U47_RS00855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2U47_RS00860	COG0101	tRNA pseudouridine synthase activity
C2U47_RS00870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U47_RS00875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U47_RS00885	COG1464	Belongs to the NlpA lipoprotein family
C2U47_RS00915	COG1119	ATPase activity
C2U47_RS00920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U47_RS00920	COG0574	Belongs to the PEP-utilizing enzyme family
C2U47_RS00925	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2U47_RS00935	COG1113	amino acid transport
C2U47_RS01010	COG1242	4 iron, 4 sulfur cluster binding
C2U47_RS01015	COG0070	glutamate synthase
C2U47_RS01015	COG0069	glutamate synthase activity
C2U47_RS01015	COG0067	glutamate synthase
C2U47_RS01020	COG0493	'glutamate synthase
C2U47_RS01025	COG1126	abc transporter atp-binding protein
C2U47_RS01030	COG0765	amino acid transport
C2U47_RS01035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_RS01060	COG4104	PAAR repeat-containing protein
C2U47_RS01070	COG0513	Belongs to the DEAD box helicase family
C2U47_RS01100	COG3706	GGDEF domain
C2U47_RS01105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U47_RS01110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2U47_RS01115	COG0505	Belongs to the CarA family
C2U47_RS01120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2U47_RS01130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U47_RS01135	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U47_RS01140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U47_RS01145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U47_RS01150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U47_RS01155	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C2U47_RS01160	COG4139	cobalamin transport
C2U47_RS01195	COG0023	Translation Initiation Factor
C2U47_RS01200	COG2119	membrane
C2U47_RS01250	COG2801	Transposase and inactivated derivatives
C2U47_RS01265	COG0215	cysteine-tRNA ligase activity
C2U47_RS01270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U47_RS01280	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U47_RS01285	COG2261	transglycosylase associated protein
C2U47_RS01290	COG1309	transcriptional regulator
C2U47_RS01295	COG0604	alcohol dehydrogenase
C2U47_RS01310	COG0583	DNA-binding transcription factor activity
C2U47_RS01335	COG0322	excinuclease ABC activity
C2U47_RS01340	COG2197	response regulator
C2U47_RS01345	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2U47_RS01350	COG2835	tetraacyldisaccharide 4'-kinase activity
C2U47_RS01355	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U47_RS01360	COG1132	(ABC) transporter
C2U47_RS01365	COG2333	competence protein COMEC
C2U47_RS01365	COG0658	competence protein
C2U47_RS01380	COG0433	COG0433 Predicted ATPase
C2U47_RS01385	COG1448	Aminotransferase
C2U47_RS01400	COG1199	ATP-dependent helicase activity
C2U47_RS01410	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2U47_RS01415	COG0477	Major facilitator Superfamily
C2U47_RS01425	COG1785	Belongs to the alkaline phosphatase family
C2U47_RS01445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U47_RS01455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_RS01460	COG0765	amino acid transport
C2U47_RS01465	COG1126	abc transporter atp-binding protein
C2U47_RS01475	COG0531	amino acid
C2U47_RS01495	COG1253	flavin adenine dinucleotide binding
C2U47_RS01500	COG0704	Plays a role in the regulation of phosphate uptake
C2U47_RS01505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2U47_RS01510	COG0581	inorganic phosphate transmembrane transporter activity
C2U47_RS01515	COG0573	inorganic phosphate transmembrane transporter activity
C2U47_RS01520	COG0590	tRNA wobble adenosine to inosine editing
C2U47_RS01535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2U47_RS01555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2U47_RS01560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2U47_RS01565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U47_RS01570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U47_RS01595	COG2716	regulation of RNA biosynthetic process
C2U47_RS01600	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2U47_RS01615	COG0675	Transposase, IS605 OrfB family
C2U47_RS01625	COG2239	Acts as a magnesium transporter
C2U47_RS01660	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2U47_RS01660	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2U47_RS01665	COG1706	bacterial-type flagellum-dependent cell motility
C2U47_RS01670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2U47_RS01685	COG1749	Flagellar hook protein flgE
C2U47_RS01700	COG1815	bacterial-type flagellum-dependent cell motility
C2U47_RS01705	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2U47_RS01710	COG0784	Response regulator, receiver
C2U47_RS01710	COG0835	chemotaxis
C2U47_RS01715	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C2U47_RS01730	COG0622	Phosphoesterase
C2U47_RS01735	COG0675	Transposase, IS605 OrfB family
C2U47_RS01745	COG4166	transmembrane transport
C2U47_RS01760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U47_RS01765	COG0675	Transposase, IS605 OrfB family
C2U47_RS01775	COG0697	spore germination
C2U47_RS01815	COG1278	Cold shock
C2U47_RS01855	COG3132	Protein of unknown function, DUF480
C2U47_RS01865	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U47_RS01885	COG3206	protein involved in exopolysaccharide biosynthesis
C2U47_RS01885	COG0489	protein tyrosine kinase activity
C2U47_RS01890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2U47_RS01910	COG0297	glycogen (starch) synthase activity
C2U47_RS01915	COG1215	transferase activity, transferring glycosyl groups
C2U47_RS01920	COG0463	Glycosyl transferase, family 2
C2U47_RS01950	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2U47_RS02035	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2U47_RS02060	COG1737	Transcriptional regulator
C2U47_RS02065	COG0469	pyruvate kinase activity
C2U47_RS02075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U47_RS02080	COG1960	acyl-CoA dehydrogenase activity
C2U47_RS02090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2U47_RS02160	COG1309	transcriptional regulator
C2U47_RS02170	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2U47_RS02175	COG1946	Acyl-CoA thioesterase
C2U47_RS02190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U47_RS02200	COG0009	L-threonylcarbamoyladenylate synthase
C2U47_RS02205	COG0613	PHP domain protein
C2U47_RS02210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2U47_RS02215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U47_RS02215	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U47_RS02220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2U47_RS02225	COG0134	indole-3-glycerol-phosphate synthase activity
C2U47_RS02225	COG0135	phosphoribosylanthranilate isomerase activity
C2U47_RS02230	COG0133	tryptophan synthase activity
C2U47_RS02235	COG0159	tryptophan synthase activity
C2U47_RS02245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U47_RS02250	COG1396	sequence-specific DNA binding
C2U47_RS02255	COG3550	peptidyl-serine autophosphorylation
C2U47_RS02290	COG4521	taurine ABC transporter
C2U47_RS02295	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U47_RS02300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U47_RS02305	COG2175	clavaminate synthase activity
C2U47_RS02315	COG5507	3-demethylubiquinone-9 3-methyltransferase
C2U47_RS02320	COG2814	Major facilitator Superfamily
C2U47_RS02325	COG0109	protoheme IX farnesyltransferase activity
C2U47_RS02330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U47_RS02335	COG1845	cytochrome c oxidase, subunit III
C2U47_RS02340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U47_RS02345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U47_RS02355	COG0583	DNA-binding transcription factor activity
C2U47_RS02370	COG0675	Transposase, IS605 OrfB family
C2U47_RS02385	COG1846	Transcriptional regulator
C2U47_RS02400	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C2U47_RS02415	COG0745	RESPONSE REGULATOR receiver
C2U47_RS02425	COG0708	Exodeoxyribonuclease III
C2U47_RS02440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_RS02445	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U47_RS02460	COG0095	Lipoate-protein ligase
C2U47_RS02490	COG0640	Transcriptional regulator
C2U47_RS02500	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U47_RS02510	COG1285	pathogenesis
C2U47_RS02540	COG0484	heat shock protein binding
C2U47_RS02545	COG0443	Heat shock 70 kDa protein
C2U47_RS02550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2U47_RS02555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2U47_RS02565	COG0497	DNA recombination
C2U47_RS02575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_RS02580	COG1136	(ABC) transporter
C2U47_RS02580	COG0577	efflux transmembrane transporter activity
C2U47_RS02585	COG1538	Outer membrane efflux protein
C2U47_RS02590	COG2375	cellular response to nickel ion
C2U47_RS02595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U47_RS02600	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U47_RS02605	COG0583	DNA-binding transcription factor activity
C2U47_RS02610	COG3048	D-serine ammonia-lyase activity
C2U47_RS02620	COG0538	isocitrate dehydrogenase activity
C2U47_RS02655	COG0456	acetyltransferase
C2U47_RS02660	COG1187	pseudouridine synthase activity
C2U47_RS02670	COG0482	sulfurtransferase activity
C2U47_RS02675	COG2915	High frequency lysogenization protein hflD homolog
C2U47_RS02680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2U47_RS02685	COG2850	peptidyl-arginine hydroxylation
C2U47_RS02695	COG1196	nuclear chromosome segregation
C2U47_RS02695	COG3264	Mechanosensitive ion channel
C2U47_RS02705	COG2706	6-phosphogluconolactonase activity
C2U47_RS02730	COG0746	molybdenum cofactor guanylyltransferase activity
C2U47_RS02740	COG1289	transmembrane transporter activity
C2U47_RS02745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U47_RS02775	COG3220	belongs to the UPF0276 family
C2U47_RS02785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U47_RS02800	COG3039	Transposase
C2U47_RS02820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U47_RS02825	COG0083	homoserine kinase activity
C2U47_RS02840	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2U47_RS02845	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2U47_RS02860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U47_RS02870	COG0745	RESPONSE REGULATOR receiver
C2U47_RS02885	COG4988	ABC transporter
C2U47_RS02890	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2U47_RS02910	COG1720	tRNA m6t6A37 methyltransferase activity
C2U47_RS02925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U47_RS02930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2U47_RS02935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U47_RS02945	COG2190	(PTS) system
C2U47_RS02950	COG3038	cytochrome b561
C2U47_RS02965	COG0420	3'-5' exonuclease activity
C2U47_RS02975	COG2974	May be involved in recombination
C2U47_RS02985	COG0405	Gamma-glutamyltransferase
C2U47_RS02990	COG4651	solute:proton antiporter activity
C2U47_RS02990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U47_RS03000	COG3385	transposase activity
C2U47_RS03030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U47_RS03035	COG1396	sequence-specific DNA binding
C2U47_RS03035	COG1917	Cupin 2, conserved barrel domain protein
C2U47_RS03040	COG1012	belongs to the aldehyde dehydrogenase family
C2U47_RS03050	COG0531	amino acid
C2U47_RS03055	COG0531	amino acid
C2U47_RS03065	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2U47_RS03075	COG3384	dioxygenase
C2U47_RS03105	COG2205	protein histidine kinase activity
C2U47_RS03105	COG0784	Response regulator, receiver
C2U47_RS03115	COG1388	LysM domain
C2U47_RS03115	COG1376	ErfK ybiS ycfS ynhG family protein
C2U47_RS03135	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C2U47_RS03140	COG0791	NLP P60 protein
C2U47_RS03150	COG3118	belongs to the thioredoxin family
C2U47_RS03160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U47_RS03165	COG0788	formyltetrahydrofolate deformylase activity
C2U47_RS03190	COG0741	lytic transglycosylase activity
C2U47_RS03190	COG0739	heme binding
C2U47_RS03190	COG1196	nuclear chromosome segregation
C2U47_RS03200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U47_RS03205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2U47_RS03210	COG0673	inositol 2-dehydrogenase activity
C2U47_RS03230	COG1032	radical SAM domain protein
C2U47_RS03235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U47_RS03245	COG3706	GGDEF domain
C2U47_RS03250	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2U47_RS03285	COG0281	malic enzyme
C2U47_RS03290	COG2207	Transcriptional regulator
C2U47_RS03315	COG0095	Lipoate-protein ligase
C2U47_RS03320	COG1115	amino acid carrier protein
C2U47_RS03325	COG0019	diaminopimelate decarboxylase activity
C2U47_RS03335	COG0678	peroxiredoxin activity
C2U47_RS03340	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C2U47_RS03350	COG1126	abc transporter atp-binding protein
C2U47_RS03355	COG0765	amino acid transport
C2U47_RS03360	COG4597	amino acid ABC transporter
C2U47_RS03365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_RS03380	COG1131	(ABC) transporter
C2U47_RS03385	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U47_RS03405	COG3142	Participates in the control of copper homeostasis
C2U47_RS03410	COG1940	carbohydrate kinase activity
C2U47_RS03420	COG4783	chaperone-mediated protein folding
C2U47_RS03430	COG5002	protein histidine kinase activity
C2U47_RS03435	COG0745	RESPONSE REGULATOR receiver
C2U47_RS03440	COG0346	lactoylglutathione lyase activity
C2U47_RS03445	COG3706	GGDEF domain
C2U47_RS03465	COG0697	spore germination
C2U47_RS03475	COG0667	Aldo Keto reductase
C2U47_RS03490	COG3290	protein histidine kinase activity
C2U47_RS03500	COG1566	PFAM secretion protein HlyD family protein
C2U47_RS03525	COG0602	queuosine metabolic process
C2U47_RS03530	COG1328	CTP reductase activity
C2U47_RS03540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U47_RS03545	COG3115	cell septum assembly
C2U47_RS03560	COG2860	membrane
C2U47_RS03570	COG3108	Peptidase M15
C2U47_RS03575	COG2989	Protein conserved in bacteria
C2U47_RS03590	COG0463	Glycosyl transferase, family 2
C2U47_RS03605	COG0366	Alpha amylase catalytic
C2U47_RS03650	COG3706	GGDEF domain
C2U47_RS03655	COG0037	tRNA processing
C2U47_RS03670	COG0488	(ABC) transporter
C2U47_RS03680	COG0531	amino acid
C2U47_RS03685	COG0814	amino acid
C2U47_RS03700	COG0825	malonyl-CoA metabolic process
C2U47_RS03705	COG0587	DNA-directed DNA polymerase activity
C2U47_RS03710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U47_RS03715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U47_RS03720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U47_RS03725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U47_RS03730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U47_RS03745	COG0750	zinc metalloprotease
C2U47_RS03750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2U47_RS03755	COG0575	Belongs to the CDS family
C2U47_RS03760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2U47_RS03765	COG0233	cytoplasmic translational termination
C2U47_RS03770	COG0528	UMP kinase activity
C2U47_RS03775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2U47_RS03780	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U47_RS03785	COG0024	Methionine aminopeptidase
C2U47_RS03790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2U47_RS03795	COG2171	N-acyltransferase activity
C2U47_RS03805	COG1263	PTS System
C2U47_RS03805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_RS03815	COG4580	involved in the transport of maltose and maltodextrins
C2U47_RS03825	COG0564	pseudouridine synthase activity
C2U47_RS03830	COG3098	single-species biofilm formation
C2U47_RS03855	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C2U47_RS03865	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U47_RS03865	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U47_RS03880	COG1611	Belongs to the LOG family
C2U47_RS03885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U47_RS03890	COG0473	3-isopropylmalate dehydrogenase activity
C2U47_RS03900	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C2U47_RS03915	COG0583	DNA-binding transcription factor activity
C2U47_RS03920	COG0840	transmembrane signaling receptor activity
C2U47_RS03925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2U47_RS03940	COG1477	protein flavinylation
C2U47_RS03945	COG2871	sodium ion transport
C2U47_RS03950	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U47_RS03955	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U47_RS03960	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U47_RS03965	COG1805	sodium ion transport
C2U47_RS03970	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U47_RS03975	COG0271	Belongs to the BolA IbaG family
C2U47_RS03980	COG2813	Specifically methylates the guanine in position
C2U47_RS03990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U47_RS04000	COG2211	Major facilitator Superfamily
C2U47_RS04010	COG1666	GTP binding
C2U47_RS04015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2U47_RS04025	COG0659	secondary active sulfate transmembrane transporter activity
C2U47_RS04030	COG5002	protein histidine kinase activity
C2U47_RS04035	COG0745	RESPONSE REGULATOR receiver
C2U47_RS04040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_RS04045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U47_RS04075	COG1609	Transcriptional regulator
C2U47_RS04080	COG2182	Extracellular solute-binding protein
C2U47_RS04085	COG0840	transmembrane signaling receptor activity
C2U47_RS04090	COG1472	Belongs to the glycosyl hydrolase 3 family
C2U47_RS04095	COG2273	Hydrolase Family 16
C2U47_RS04095	COG5297	Belongs to the glycosyl hydrolase family 6
C2U47_RS04100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2U47_RS04110	COG2723	6-phospho-beta-galactosidase activity
C2U47_RS04115	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2U47_RS04135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U47_RS04145	COG1151	hydroxylamine reductase activity
C2U47_RS04150	COG0783	Belongs to the Dps family
C2U47_RS04190	COG4221	oxidoreductase activity
C2U47_RS04200	COG0415	Belongs to the DNA photolyase family
C2U47_RS04205	COG0789	Transcriptional regulator
C2U47_RS04210	COG3272	Protein of unknown function (DUF1722)
C2U47_RS04235	COG0077	Prephenate dehydratase
C2U47_RS04235	COG1605	Chorismate mutase
C2U47_RS04265	COG2133	pyrroloquinoline quinone binding
C2U47_RS04275	COG1349	DNA-binding transcription factor activity
C2U47_RS04280	COG2084	Dehydrogenase
C2U47_RS04285	COG3395	kinase activity
C2U47_RS04290	COG0235	Class ii aldolase
C2U47_RS04295	COG3622	Belongs to the hyi family
C2U47_RS04300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U47_RS04305	COG2610	gluconate transmembrane transporter activity
C2U47_RS04325	COG0300	oxidoreductase activity
C2U47_RS04350	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2U47_RS04370	COG3813	Protein conserved in bacteria
C2U47_RS04380	COG0826	peptidase U32
C2U47_RS04385	COG1280	lysine exporter protein (LysE YggA)
C2U47_RS04395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U47_RS04420	COG2199	diguanylate cyclase activity
C2U47_RS04420	COG2203	Gaf domain
C2U47_RS04420	COG2200	EAL domain
C2U47_RS04455	COG3504	Conjugal transfer protein
C2U47_RS04480	COG3451	type IV secretory pathway VirB4
C2U47_RS04490	COG3838	Conjugal transfer protein Trbc
C2U47_RS04495	COG4962	Type ii secretion system protein e
C2U47_RS04525	COG4804	nuclease activity
C2U47_RS04530	COG2003	Belongs to the UPF0758 family
C2U47_RS04550	COG2076	Multidrug Resistance protein
C2U47_RS04580	COG4962	Type ii secretion system protein e
C2U47_RS04585	COG3838	Conjugal transfer protein Trbc
C2U47_RS04595	COG3451	type IV secretory pathway VirB4
C2U47_RS04610	COG3846	protein secretion by the type IV secretion system
C2U47_RS04670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U47_RS04675	COG1127	ABC transporter
C2U47_RS04700	COG4959	Type IV secretory pathway protease TraF
C2U47_RS04715	COG1192	Involved in chromosome partitioning
C2U47_RS04755	COG5489	Protein of unknown function (DUF736)
C2U47_RS04790	COG2003	Belongs to the UPF0758 family
C2U47_RS04795	COG4804	nuclease activity
C2U47_RS04825	COG1566	PFAM secretion protein HlyD family protein
C2U47_RS04835	COG0114	fumarate hydratase activity
C2U47_RS04845	COG0506	proline dehydrogenase activity
C2U47_RS04845	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U47_RS04845	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U47_RS04850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U47_RS04865	COG0737	Belongs to the 5'-nucleotidase family
C2U47_RS04885	COG2204	response regulator
C2U47_RS04890	COG0545	Peptidyl-prolyl cis-trans isomerase
C2U47_RS04900	COG2900	Belongs to the SlyX family
C2U47_RS04905	COG1047	Peptidyl-prolyl cis-trans
C2U47_RS04910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C2U47_RS04920	COG0784	Response regulator, receiver
C2U47_RS04920	COG0835	chemotaxis
C2U47_RS04925	COG0429	hydrolase of the alpha beta-hydrolase fold
C2U47_RS04930	COG4251	negative regulation of phosphorylation
C2U47_RS04930	COG5001	Diguanylate cyclase
C2U47_RS04930	COG2203	Gaf domain
C2U47_RS04930	COG3706	GGDEF domain
C2U47_RS04935	COG3089	Belongs to the UPF0270 family
C2U47_RS04940	COG3954	Phosphoribulokinase
C2U47_RS04955	COG1765	OsmC-like protein
C2U47_RS04965	COG2226	methyltransferase
C2U47_RS04975	COG2202	Pas domain
C2U47_RS04975	COG2205	protein histidine kinase activity
C2U47_RS04980	COG2814	Major facilitator Superfamily
C2U47_RS05005	COG0748	coenzyme F420 binding
C2U47_RS05010	COG3721	Heme iron utilization protein
C2U47_RS05020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U47_RS05045	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U47_RS05055	COG0463	Glycosyl transferase, family 2
C2U47_RS05060	COG1196	nuclear chromosome segregation
C2U47_RS05060	COG0741	lytic transglycosylase activity
C2U47_RS05060	COG0739	heme binding
C2U47_RS05065	COG0488	(ABC) transporter
C2U47_RS05075	COG2252	PERMEase
C2U47_RS05080	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U47_RS05085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U47_RS05090	COG3178	'Phosphotransferase
C2U47_RS05095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2U47_RS05105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U47_RS05110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U47_RS05115	COG2967	ApaG domain
C2U47_RS05120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U47_RS05130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U47_RS05135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2U47_RS05140	COG3314	Sporulation integral membrane protein YlbJ
C2U47_RS05145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U47_RS05150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2U47_RS05155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2U47_RS05160	COG0142	geranyltranstransferase activity
C2U47_RS05165	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2U47_RS05170	COG0330	HflC and HflK could
C2U47_RS05175	COG0330	HflC and HflK could
C2U47_RS05180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U47_RS05185	COG1923	regulation of RNA biosynthetic process
C2U47_RS05190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2U47_RS05195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U47_RS05205	COG0802	atpase or kinase
C2U47_RS05210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U47_RS05210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U47_RS05230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U47_RS05235	COG2011	ABC-type metal ion transport system permease component
C2U47_RS05240	COG1464	Belongs to the NlpA lipoprotein family
C2U47_RS05260	COG0784	Response regulator, receiver
C2U47_RS05260	COG2205	protein histidine kinase activity
C2U47_RS05275	COG5002	protein histidine kinase activity
C2U47_RS05275	COG0784	Response regulator, receiver
C2U47_RS05275	COG2198	Histidine kinase
C2U47_RS05295	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C2U47_RS05310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2U47_RS05315	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2U47_RS05320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U47_RS05325	COG2716	regulation of RNA biosynthetic process
C2U47_RS05330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U47_RS05335	COG3013	Belongs to the UPF0304 family
C2U47_RS05345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U47_RS05350	COG0280	phosphate acetyltransferase
C2U47_RS05350	COG0857	belongs to the CobB CobQ family
C2U47_RS05355	COG0440	acetolactate synthase activity
C2U47_RS05360	COG0028	Belongs to the TPP enzyme family
C2U47_RS05375	COG0671	phosphoesterase, PA-phosphatase related
C2U47_RS05385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U47_RS05390	COG0473	3-isopropylmalate dehydrogenase activity
C2U47_RS05395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2U47_RS05400	COG0066	3-isopropylmalate dehydratase activity
C2U47_RS05415	COG4143	(ABC) transporter
C2U47_RS05420	COG1178	ABC-type Fe3 transport system permease component
C2U47_RS05425	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C2U47_RS05430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2U47_RS05440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U47_RS05470	COG0316	Belongs to the HesB IscA family
C2U47_RS05480	COG0038	chloride channel
C2U47_RS05485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U47_RS05500	COG0671	phosphoesterase, PA-phosphatase related
C2U47_RS05510	COG0583	DNA-binding transcription factor activity
C2U47_RS05515	COG2076	Multidrug Resistance protein
C2U47_RS05525	COG0346	lactoylglutathione lyase activity
C2U47_RS05530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U47_RS05535	COG1643	Atp-dependent helicase
C2U47_RS05545	COG1489	DNA binding
C2U47_RS05550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2U47_RS05555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U47_RS05565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2U47_RS05570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2U47_RS05575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2U47_RS05585	COG0842	Transport permease protein
C2U47_RS05590	COG1131	(ABC) transporter
C2U47_RS05605	COG0163	prenyltransferase activity
C2U47_RS05610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U47_RS05615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U47_RS05630	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C2U47_RS05645	COG1136	(ABC) transporter
C2U47_RS05690	COG2801	Transposase and inactivated derivatives
C2U47_RS05695	COG0529	Catalyzes the synthesis of activated sulfate
C2U47_RS05700	COG0471	metal ion transport
C2U47_RS05700	COG3273	potassium ion transport
C2U47_RS05705	COG2895	sulfate adenylyltransferase (ATP) activity
C2U47_RS05710	COG0175	sulfate reduction
C2U47_RS05720	COG0330	HflC and HflK could
C2U47_RS05725	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2U47_RS05735	COG0673	inositol 2-dehydrogenase activity
C2U47_RS05745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2U47_RS05750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U47_RS05755	COG3036	rescue of stalled ribosome
C2U47_RS05770	COG0138	bifunctional purine biosynthesis protein purh
C2U47_RS05805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2U47_RS05810	COG0358	DNA primase activity
C2U47_RS05815	COG1610	YqeY-like protein
C2U47_RS05820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U47_RS05825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2U47_RS05835	COG4942	peptidase
C2U47_RS05835	COG1388	LysM domain
C2U47_RS05840	COG1238	metal cluster binding
C2U47_RS05845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U47_RS05850	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2U47_RS05855	COG0585	pseudouridine synthase activity
C2U47_RS05865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2U47_RS05870	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2U47_RS05875	COG0148	phosphopyruvate hydratase activity
C2U47_RS05880	COG0504	CTP synthase activity
C2U47_RS05885	COG3956	TIGRFAM MazG family protein
C2U47_RS05890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U47_RS05895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U47_RS05905	COG4807	Protein conserved in bacteria
C2U47_RS05910	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U47_RS05915	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U47_RS05920	COG1381	Involved in DNA repair and RecF pathway recombination
C2U47_RS05930	COG0571	ribonuclease III activity
C2U47_RS05935	COG0681	Belongs to the peptidase S26 family
C2U47_RS05940	COG0481	GTPase activity
C2U47_RS05955	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C2U47_RS05960	COG1595	DNA-templated transcription, initiation
C2U47_RS05965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U47_RS05975	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U47_RS05985	COG0583	DNA-binding transcription factor activity
C2U47_RS06015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U47_RS06025	COG0126	phosphoglycerate kinase activity
C2U47_RS06030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U47_RS06035	COG1940	carbohydrate kinase activity
C2U47_RS06040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2U47_RS06055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U47_RS06070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U47_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
C2U47_RS06090	COG1505	serine-type exopeptidase activity
C2U47_RS06095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2U47_RS06100	COG0765	amino acid transport
C2U47_RS06105	COG0765	amino acid transport
C2U47_RS06110	COG1126	abc transporter atp-binding protein
C2U47_RS06115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_RS06120	COG3174	membrane
C2U47_RS06125	COG0110	maltose O-acetyltransferase activity
C2U47_RS06155	COG1942	4-Oxalocrotonate Tautomerase
C2U47_RS06165	COG0583	DNA-binding transcription factor activity
C2U47_RS06170	COG0165	Argininosuccinate lyase
C2U47_RS06175	COG0137	argininosuccinate synthase activity
C2U47_RS06185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U47_RS06190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U47_RS06200	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2U47_RS06205	COG5001	Diguanylate cyclase
C2U47_RS06205	COG3447	MASE1 domain protein
C2U47_RS06205	COG5002	protein histidine kinase activity
C2U47_RS06210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U47_RS06245	COG0583	DNA-binding transcription factor activity
C2U47_RS06250	COG1380	Effector of murein hydrolase LrgA
C2U47_RS06255	COG1346	cytolysis
C2U47_RS06260	COG0527	aspartate kinase activity
C2U47_RS06260	COG0460	homoserine dehydrogenase
C2U47_RS06265	COG0626	cystathionine gamma-synthase activity
C2U47_RS06280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U47_RS06285	COG0814	amino acid
C2U47_RS06290	COG1218	3'(2'),5'-bisphosphate nucleotidase
C2U47_RS06295	COG0494	nUDIX hydrolase
C2U47_RS06300	COG1011	Hydrolase
C2U47_RS06305	COG1902	pentaerythritol trinitrate reductase activity
C2U47_RS06315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U47_RS06330	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C2U47_RS06340	COG3156	type II secretion system protein K
C2U47_RS06350	COG4795	General secretion pathway protein
C2U47_RS06355	COG2165	general secretion pathway protein
C2U47_RS06365	COG2165	general secretion pathway protein
C2U47_RS06370	COG1459	type II secretion system
C2U47_RS06375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U47_RS06385	COG3031	protein transport across the cell outer membrane
C2U47_RS06395	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U47_RS06400	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2U47_RS06415	COG0456	acetyltransferase
C2U47_RS06420	COG3133	Outer membrane lipoprotein
C2U47_RS06425	COG3025	triphosphatase activity
C2U47_RS06430	COG1392	Phosphate transport regulator
C2U47_RS06435	COG0306	phosphate transporter
C2U47_RS06440	COG0617	tRNA 3'-terminal CCA addition
C2U47_RS06445	COG3409	Peptidoglycan-binding domain 1 protein
C2U47_RS06445	COG3267	Type II secretory pathway component ExeA
C2U47_RS06455	COG1194	a g-specific adenine glycosylase
C2U47_RS06460	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2U47_RS06475	COG3240	lipase activity
C2U47_RS06485	COG3009	Protein conserved in bacteria
C2U47_RS06490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U47_RS06490	COG3008	intermembrane lipid transfer
C2U47_RS06495	COG2995	paraquat-inducible protein a
C2U47_RS06505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U47_RS06515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U47_RS06520	COG2813	Specifically methylates the guanine in position
C2U47_RS06530	COG0297	glycogen (starch) synthase activity
C2U47_RS06570	COG1757	Na H antiporter
C2U47_RS06580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2U47_RS06585	COG3842	ATPase activity
C2U47_RS06590	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U47_RS06595	COG1177	transmembrane transport
C2U47_RS06600	COG1012	belongs to the aldehyde dehydrogenase family
C2U47_RS06605	COG0109	protoheme IX farnesyltransferase activity
C2U47_RS06635	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C2U47_RS06645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U47_RS06645	COG1565	acr, cog1565
C2U47_RS06650	COG1444	tRNA N-acetyltransferase activity
C2U47_RS06670	COG1803	Methylglyoxal synthase
C2U47_RS06705	COG1263	PTS System
C2U47_RS06705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_RS06710	COG0366	Alpha amylase catalytic
C2U47_RS06715	COG0110	maltose O-acetyltransferase activity
C2U47_RS06720	COG1522	sequence-specific DNA binding
C2U47_RS06750	COG3068	Protein conserved in bacteria
C2U47_RS06760	COG0739	heme binding
C2U47_RS06780	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C2U47_RS06785	COG1121	(ABC) transporter
C2U47_RS06790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2U47_RS06795	COG0583	DNA-binding transcription factor activity
C2U47_RS06805	COG1573	uracil-dna glycosylase
C2U47_RS06810	COG2962	Rard protein
C2U47_RS06815	COG2827	Endonuclease containing a URI domain
C2U47_RS06830	COG1842	Phage shock protein A
C2U47_RS06835	COG0204	Acyl-transferase
C2U47_RS06855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U47_RS06865	COG0484	heat shock protein binding
C2U47_RS06920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2U47_RS06930	COG3039	Transposase
C2U47_RS06995	COG2801	Transposase and inactivated derivatives
C2U47_RS07020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_RS07030	COG0789	Transcriptional regulator
C2U47_RS07105	COG4974	Belongs to the 'phage' integrase family
C2U47_RS07120	COG0795	lipopolysaccharide-transporting ATPase activity
C2U47_RS07125	COG0795	lipopolysaccharide-transporting ATPase activity
C2U47_RS07130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U47_RS07135	COG2927	DNA polymerase III (CHI subunit)
C2U47_RS07140	COG0525	valine-tRNA ligase activity
C2U47_RS07145	COG1253	flavin adenine dinucleotide binding
C2U47_RS07150	COG0586	Pfam SNARE associated Golgi protein
C2U47_RS07155	COG1686	Belongs to the peptidase S11 family
C2U47_RS07190	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2U47_RS07195	COG0527	aspartate kinase activity
C2U47_RS07200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U47_RS07205	COG2137	regulation of response to DNA damage stimulus
C2U47_RS07210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2U47_RS07215	COG1546	Belongs to the CinA family
C2U47_RS07225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2U47_RS07270	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2U47_RS07275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2U47_RS07295	COG0523	cobalamin synthesis protein
C2U47_RS07305	COG1280	lysine exporter protein (LysE YggA)
C2U47_RS07315	COG2200	EAL domain
C2U47_RS07320	COG1049	propionate catabolic process, 2-methylcitrate cycle
C2U47_RS07330	COG0840	transmembrane signaling receptor activity
C2U47_RS07335	COG0840	transmembrane signaling receptor activity
C2U47_RS07345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U47_RS07350	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U47_RS07355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U47_RS07360	COG2186	Transcriptional regulator
C2U47_RS07390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U47_RS07395	COG1459	type II secretion system
C2U47_RS07400	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2U47_RS07410	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2U47_RS07415	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2U47_RS07420	COG0494	nUDIX hydrolase
C2U47_RS07430	COG0653	protein targeting
C2U47_RS07440	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2U47_RS07445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2U47_RS07450	COG0849	cell division
C2U47_RS07455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U47_RS07460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U47_RS07465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U47_RS07470	COG0772	Belongs to the SEDS family
C2U47_RS07475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2U47_RS07485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2U47_RS07490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U47_RS07495	COG0768	penicillin binding
C2U47_RS07500	COG3116	cell division
C2U47_RS07505	COG0275	rRNA processing
C2U47_RS07510	COG2001	Belongs to the MraZ family
C2U47_RS07520	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2U47_RS07525	COG3107	peptidoglycan biosynthetic process
C2U47_RS07530	COG0792	nuclease activity
C2U47_RS07535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U47_RS07540	COG2823	Periplasmic or secreted lipoprotein
C2U47_RS07545	COG2969	positive regulation of protein catabolic process
C2U47_RS07550	COG0625	glutathione transferase activity
C2U47_RS07555	COG2857	Cytochrome c1
C2U47_RS07560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2U47_RS07565	COG0723	plastoquinol--plastocyanin reductase activity
C2U47_RS07570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U47_RS07575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U47_RS07580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U47_RS07590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U47_RS07595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U47_RS07625	COG3964	amidohydrolase
C2U47_RS07645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U47_RS07650	COG1660	Displays ATPase and GTPase activities
C2U47_RS07655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U47_RS07665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2U47_RS07670	COG1137	ATPase activity
C2U47_RS07675	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C2U47_RS07685	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U47_RS07690	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U47_RS07690	COG0517	IMP dehydrogenase activity
C2U47_RS07695	COG1127	ABC transporter
C2U47_RS07700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U47_RS07705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U47_RS07710	COG2854	intermembrane phospholipid transfer
C2U47_RS07720	COG5007	Belongs to the BolA IbaG family
C2U47_RS07725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U47_RS07735	COG1494	fructose-1,6-bisphosphatase
C2U47_RS07745	COG2226	methyltransferase
C2U47_RS07770	COG1733	regulation of RNA biosynthetic process
C2U47_RS07790	COG3932	Exopolysaccharide synthesis, ExoD
C2U47_RS07805	COG0110	maltose O-acetyltransferase activity
C2U47_RS07825	COG2801	Transposase and inactivated derivatives
C2U47_RS07830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U47_RS07835	COG2022	thiamine diphosphate biosynthetic process
C2U47_RS07845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U47_RS07850	COG0352	thiamine-phosphate diphosphorylase activity
C2U47_RS07855	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2U47_RS07870	COG0745	RESPONSE REGULATOR receiver
C2U47_RS07875	COG0642	Histidine kinase
C2U47_RS07880	COG0189	ligase activity
C2U47_RS07915	COG2321	neutral zinc metallopeptidase
C2U47_RS07925	COG0477	Major facilitator Superfamily
C2U47_RS07940	COG0312	modulator of DNA gyrase
C2U47_RS07945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U47_RS07950	COG3164	Protein of unknown function
C2U47_RS07955	COG1530	ribonuclease E activity
C2U47_RS07960	COG0424	maF-like protein
C2U47_RS07965	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2U47_RS07970	COG1792	Involved in formation and maintenance of cell shape
C2U47_RS07975	COG1077	Cell shape determining protein MreB Mrl
C2U47_RS08005	COG2165	general secretion pathway protein
C2U47_RS08020	COG1459	type II secretion system
C2U47_RS08025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U47_RS08075	COG2200	EAL domain
C2U47_RS08080	COG0387	Pfam Sodium calcium exchanger
C2U47_RS08085	COG2986	histidine ammonia-lyase
C2U47_RS08090	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2U47_RS08095	COG0010	Belongs to the arginase family
C2U47_RS08100	COG1228	amidohydrolase
C2U47_RS08105	COG2188	Transcriptional regulator
C2U47_RS08110	COG0288	reversible hydration of carbon dioxide
C2U47_RS08120	COG2177	Part of the ABC transporter FtsEX involved in
C2U47_RS08125	COG2884	Cell division ATP-binding protein ftsE
C2U47_RS08130	COG0552	protein localization to endoplasmic reticulum
C2U47_RS08135	COG0742	ribosomal rna small subunit methyltransferase
C2U47_RS08160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U47_RS08165	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U47_RS08175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U47_RS08185	COG2095	MarC family integral membrane protein
C2U47_RS08195	COG1301	dicarboxylic acid transport
C2U47_RS08205	COG0583	DNA-binding transcription factor activity
C2U47_RS08220	COG3714	YhhN family
C2U47_RS08235	COG2358	TRAP transporter, solute receptor (TAXI family
C2U47_RS08255	COG4221	oxidoreductase activity
C2U47_RS08260	COG0583	DNA-binding transcription factor activity
C2U47_RS08265	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2U47_RS08335	COG0203	ribosomal protein L17
C2U47_RS08340	COG0202	RNA polymerase activity
C2U47_RS08345	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2U47_RS08350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2U47_RS08355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2U47_RS08360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U47_RS08365	COG0201	protein transport
C2U47_RS08370	COG0200	Binds to the 23S rRNA
C2U47_RS08375	COG1841	ribosomal large subunit assembly
C2U47_RS08380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2U47_RS08385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2U47_RS08390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2U47_RS08395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2U47_RS08400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2U47_RS08405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2U47_RS08410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2U47_RS08415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2U47_RS08420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2U47_RS08425	COG0255	Belongs to the universal ribosomal protein uL29 family
C2U47_RS08430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2U47_RS08435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2U47_RS08440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2U47_RS08445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2U47_RS08450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2U47_RS08455	COG0089	rRNA binding
C2U47_RS08460	COG0088	Forms part of the polypeptide exit tunnel
C2U47_RS08465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U47_RS08470	COG0051	transcription antitermination factor activity, RNA binding
C2U47_RS08480	COG2205	protein histidine kinase activity
C2U47_RS08495	COG2183	response to ionizing radiation
C2U47_RS08510	COG0596	Alpha beta hydrolase
C2U47_RS08515	COG1040	competence protein
C2U47_RS08520	COG0316	Belongs to the HesB IscA family
C2U47_RS08520	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2U47_RS08525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2U47_RS08530	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2U47_RS08535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U47_RS08540	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2U47_RS08545	COG4942	peptidase
C2U47_RS08555	COG1609	Transcriptional regulator
C2U47_RS08570	COG0800	Aldolase
C2U47_RS08575	COG0129	dihydroxy-acid dehydratase activity
C2U47_RS08580	COG3265	gluconokinase activity
C2U47_RS08585	COG2610	gluconate transmembrane transporter activity
C2U47_RS08590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U47_RS08595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U47_RS08605	COG0456	acetyltransferase
C2U47_RS08615	COG1490	D-aminoacyl-tRNA deacylase activity
C2U47_RS08620	COG1295	ribonuclease BN
C2U47_RS08625	COG1217	gtp-binding protein TYPA
C2U47_RS08630	COG0174	glutamine synthetase
C2U47_RS08640	COG3852	Histidine kinase
C2U47_RS08650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2U47_RS08665	COG3078	GTPase activator activity
C2U47_RS08675	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2U47_RS08685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U47_RS08690	COG0408	coproporphyrinogen oxidase activity
C2U47_RS08695	COG0009	L-threonylcarbamoyladenylate synthase
C2U47_RS08700	COG0551	DNA topoisomerase type I activity
C2U47_RS08705	COG2922	Belongs to the Smg family
C2U47_RS08710	COG0758	DNA mediated transformation
C2U47_RS08720	COG0242	peptide deformylase activity
C2U47_RS08725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2U47_RS08730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U47_RS08730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U47_RS08735	COG0569	domain protein
C2U47_RS08740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U47_RS08745	COG1322	Protein conserved in bacteria
C2U47_RS08765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U47_RS08775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U47_RS08775	COG0519	Catalyzes the synthesis of GMP from XMP
C2U47_RS08785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2U47_RS08790	COG1396	sequence-specific DNA binding
C2U47_RS08795	COG1012	belongs to the aldehyde dehydrogenase family
C2U47_RS08810	COG1280	lysine exporter protein (LysE YggA)
C2U47_RS08850	COG0583	DNA-binding transcription factor activity
C2U47_RS08855	COG1943	Transposase
C2U47_RS08870	COG3039	Transposase
C2U47_RS08880	COG0210	DNA helicase
C2U47_RS08895	COG1744	ABC transporter substrate-binding protein PnrA-like
C2U47_RS08900	COG3845	ABC transporter
C2U47_RS08905	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2U47_RS08910	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2U47_RS08915	COG0583	DNA-binding transcription factor activity
C2U47_RS08940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U47_RS08945	COG0385	Bile acid
C2U47_RS08950	COG0531	amino acid
C2U47_RS08955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U47_RS08960	COG0531	amino acid
C2U47_RS08965	COG2731	YhcH YjgK YiaL family protein
C2U47_RS08970	COG3250	beta-galactosidase activity
C2U47_RS08975	COG1609	Transcriptional regulator
C2U47_RS09010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2U47_RS09015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U47_RS09015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U47_RS09020	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C2U47_RS09025	COG3074	FtsZ-dependent cytokinesis
C2U47_RS09035	COG1045	serine acetyltransferase
C2U47_RS09045	COG0745	RESPONSE REGULATOR receiver
C2U47_RS09050	COG2205	protein histidine kinase activity
C2U47_RS09055	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2U47_RS09060	COG0534	Mate efflux family protein
C2U47_RS09075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U47_RS09080	COG2937	Belongs to the GPAT DAPAT family
C2U47_RS09090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2U47_RS09095	COG3161	chorismate lyase activity
C2U47_RS09100	COG1580	Controls the rotational direction of flagella during chemotaxis
C2U47_RS09120	COG1609	Transcriptional regulator
C2U47_RS09170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U47_RS09185	COG1063	alcohol dehydrogenase
C2U47_RS09205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2U47_RS09210	COG2166	iron-sulfur cluster assembly
C2U47_RS09215	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U47_RS09250	COG3655	Transcriptional regulator
C2U47_RS09265	COG5433	transposase activity
C2U47_RS09325	COG2855	membrane
C2U47_RS09340	COG3385	transposase activity
C2U47_RS09345	COG1484	DNA-dependent DNA replication
C2U47_RS09350	COG4584	PFAM Integrase catalytic
C2U47_RS09385	COG5433	transposase activity
C2U47_RS09460	COG5433	transposase activity
C2U47_RS09475	COG4753	response regulator
C2U47_RS09475	COG2207	Transcriptional regulator
C2U47_RS09480	COG0642	Histidine kinase
C2U47_RS09490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U47_RS09520	COG3385	transposase activity
C2U47_RS09535	COG1484	DNA-dependent DNA replication
C2U47_RS09540	COG4584	PFAM Integrase catalytic
C2U47_RS09580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U47_RS09605	COG1484	DNA-dependent DNA replication
C2U47_RS09640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_RS09645	COG0840	transmembrane signaling receptor activity
C2U47_RS09650	COG3039	Transposase
C2U47_RS09655	COG3385	transposase activity
C2U47_RS09685	COG4584	PFAM Integrase catalytic
C2U47_RS09690	COG1484	DNA-dependent DNA replication
C2U47_RS09740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2U47_RS09745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U47_RS09750	COG2223	nitrite transmembrane transporter activity
C2U47_RS09755	COG3279	Response regulator of the LytR AlgR family
C2U47_RS09760	COG3275	phosphorelay sensor kinase activity
C2U47_RS09770	COG2205	protein histidine kinase activity
C2U47_RS09770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_RS09790	COG3188	usher protein
C2U47_RS09805	COG1280	lysine exporter protein (LysE YggA)
C2U47_RS09810	COG2223	nitrite transmembrane transporter activity
C2U47_RS09815	COG2081	HI0933 family
C2U47_RS09820	COG1528	Iron-storage protein
C2U47_RS09825	COG3706	GGDEF domain
C2U47_RS09830	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U47_RS09840	COG0589	response to stress
C2U47_RS09880	COG3642	lipopolysaccharide core region biosynthetic process
C2U47_RS09885	COG0859	PFAM glycosyl transferase family 9
C2U47_RS09900	COG1758	RNA polymerase activity
C2U47_RS09905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U47_RS09910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U47_RS09915	COG2267	carboxylic ester hydrolase activity
C2U47_RS09920	COG0561	phosphatase activity
C2U47_RS09950	COG1309	transcriptional regulator
C2U47_RS09955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_RS09960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U47_RS09965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_RS09965	COG4191	Histidine kinase
C2U47_RS09970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U47_RS09995	COG2205	protein histidine kinase activity
C2U47_RS10000	COG0745	RESPONSE REGULATOR receiver
C2U47_RS10005	COG2814	Major facilitator Superfamily
C2U47_RS10020	COG3977	Valine--pyruvate aminotransferase
C2U47_RS10025	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U47_RS10030	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U47_RS10035	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2U47_RS10040	COG2207	Transcriptional regulator
C2U47_RS10045	COG0187	DNA topoisomerase II activity
C2U47_RS10055	COG0592	DNA-directed DNA polymerase activity
C2U47_RS10060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2U47_RS10075	COG1126	abc transporter atp-binding protein
C2U47_RS10080	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2U47_RS10085	COG0594	ribonuclease P activity
C2U47_RS10090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2U47_RS10095	COG0706	membrane insertase activity
C2U47_RS10100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2U47_RS10125	COG3550	peptidyl-serine autophosphorylation
C2U47_RS10135	COG3385	transposase activity
C2U47_RS10145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U47_RS10150	COG1120	ATPase activity
C2U47_RS10155	COG4615	Cyclic peptide transporter
C2U47_RS10160	COG4774	siderophore transport
C2U47_RS10165	COG0716	FMN binding
C2U47_RS10170	COG0445	tRNA wobble uridine modification
C2U47_RS10175	COG0357	Ribosomal RNA small subunit methyltransferase G
C2U47_RS10180	COG1192	Involved in chromosome partitioning
C2U47_RS10185	COG1475	DNA binding
C2U47_RS10195	COG0356	it plays a direct role in the translocation of protons across the membrane
C2U47_RS10205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2U47_RS10210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2U47_RS10215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U47_RS10220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2U47_RS10225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2U47_RS10230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2U47_RS10235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2U47_RS10240	COG4452	Inner membrane protein CreD
C2U47_RS10255	COG0745	RESPONSE REGULATOR receiver
C2U47_RS10260	COG1349	DNA-binding transcription factor activity
C2U47_RS10265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U47_RS10310	COG1111	helicase
C2U47_RS10310	COG1205	dead DEAH box helicase
C2U47_RS10315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U47_RS10345	COG2771	luxR family
C2U47_RS10355	COG0811	peptide transport
C2U47_RS10360	COG0811	peptide transport
C2U47_RS10365	COG0848	biopolymer transport protein
C2U47_RS10370	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2U47_RS10405	COG0402	S-adenosylhomocysteine deaminase activity
C2U47_RS10410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2U47_RS10420	COG3165	ubiquinone biosynthetic process from chorismate
C2U47_RS10425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U47_RS10430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U47_RS10435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U47_RS10440	COG0805	protein transport
C2U47_RS10445	COG0084	hydrolase, TatD family'
C2U47_RS10465	COG0742	ribosomal rna small subunit methyltransferase
C2U47_RS10475	COG0248	Ppx GppA phosphatase
C2U47_RS10480	COG0513	Belongs to the DEAD box helicase family
C2U47_RS10485	COG3118	belongs to the thioredoxin family
C2U47_RS10500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U47_RS10510	COG2960	long-chain fatty acid transporting porin activity
C2U47_RS10525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U47_RS10565	COG1609	Transcriptional regulator
C2U47_RS10570	COG3604	Transcriptional regulator
C2U47_RS10575	COG0426	domain, Protein
C2U47_RS10575	COG1773	rubredoxin
C2U47_RS10580	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U47_RS10590	COG0348	domain, Protein
C2U47_RS10600	COG3033	Beta-eliminating lyase
C2U47_RS10605	COG0814	amino acid
C2U47_RS10610	COG0814	amino acid
C2U47_RS10630	COG2203	Gaf domain
C2U47_RS10630	COG4251	negative regulation of phosphorylation
C2U47_RS10630	COG5001	Diguanylate cyclase
C2U47_RS10630	COG3706	GGDEF domain
C2U47_RS10635	COG0751	glycine-tRNA ligase activity
C2U47_RS10640	COG0752	glycyl-tRNA synthetase alpha subunit
C2U47_RS10645	COG2818	Glycosylase
C2U47_RS10650	COG1335	isochorismatase
C2U47_RS10665	COG2885	chlorophyll binding
C2U47_RS10685	COG0251	oxidation-reduction process
C2U47_RS10690	COG0425	Belongs to the sulfur carrier protein TusA family
C2U47_RS10730	COG0183	Belongs to the thiolase family
C2U47_RS10735	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U47_RS10735	COG1024	Enoyl-CoA hydratase
C2U47_RS10740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U47_RS10745	COG0006	proline dipeptidase activity
C2U47_RS10750	COG1739	Uncharacterized protein family UPF0029
C2U47_RS10755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U47_RS10760	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C2U47_RS10785	COG1042	CoA-binding domain protein
C2U47_RS10785	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U47_RS10785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U47_RS10795	COG0583	DNA-binding transcription factor activity
C2U47_RS10800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U47_RS10805	COG0166	Belongs to the GPI family
C2U47_RS10815	COG0668	transmembrane transport
C2U47_RS10825	COG1309	transcriptional regulator
C2U47_RS10830	COG0756	dUTP diphosphatase activity
C2U47_RS10835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U47_RS10840	COG2003	Belongs to the UPF0758 family
C2U47_RS10845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2U47_RS10850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2U47_RS10860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2U47_RS10865	COG2990	Protein conserved in bacteria
C2U47_RS10870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2U47_RS10875	COG0859	PFAM glycosyl transferase family 9
C2U47_RS10880	COG0463	Glycosyl transferase, family 2
C2U47_RS10885	COG0859	PFAM glycosyl transferase family 9
C2U47_RS10890	COG1519	Transferase
C2U47_RS10900	COG1561	YicC-like family, N-terminal region
C2U47_RS10905	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2U47_RS10910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2U47_RS10925	COG5001	Diguanylate cyclase
C2U47_RS10925	COG4251	negative regulation of phosphorylation
C2U47_RS10925	COG3706	GGDEF domain
C2U47_RS10925	COG2203	Gaf domain
C2U47_RS10930	COG3084	Protein conserved in bacteria
C2U47_RS10940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2U47_RS10945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U47_RS10955	COG1335	isochorismatase
C2U47_RS10965	COG1683	Conserved Protein
C2U47_RS10970	COG0204	Acyl-transferase
C2U47_RS10975	COG0204	Acyl-transferase
C2U47_RS11020	COG4584	PFAM Integrase catalytic
C2U47_RS11025	COG1484	DNA-dependent DNA replication
C2U47_RS11095	COG3978	acetolactate synthase activity
C2U47_RS11105	COG0129	dihydroxy-acid dehydratase activity
C2U47_RS11120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U47_RS11125	COG0254	rRNA binding
C2U47_RS11130	COG0702	epimerase
C2U47_RS11135	COG0281	malic enzyme
C2U47_RS11145	COG2205	protein histidine kinase activity
C2U47_RS11155	COG0745	RESPONSE REGULATOR receiver
C2U47_RS11160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U47_RS11205	COG0366	Alpha amylase catalytic
C2U47_RS11220	COG0443	Heat shock 70 kDa protein
C2U47_RS11225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U47_RS11230	COG3045	CreA protein
C2U47_RS11250	COG0174	glutamine synthetase
C2U47_RS11270	COG3842	ATPase activity
C2U47_RS11275	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U47_RS11280	COG1177	transmembrane transport
C2U47_RS11285	COG2258	MOSC domain
C2U47_RS11300	COG2050	protein possibly involved in aromatic compounds catabolism
C2U47_RS11305	COG0514	ATP-dependent DNA helicase (RecQ)
C2U47_RS11315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U47_RS11325	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2U47_RS11330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U47_RS11340	COG1648	precorrin-2 dehydrogenase activity
C2U47_RS11340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U47_RS11345	COG2116	formate transmembrane transporter activity
C2U47_RS11355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U47_RS11360	COG0842	Transport permease protein
C2U47_RS11365	COG0842	Transport permease protein
C2U47_RS11370	COG1131	(ABC) transporter
C2U47_RS11375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_RS11390	COG0477	Major facilitator Superfamily
C2U47_RS11395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2U47_RS11400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2U47_RS11420	COG1595	DNA-templated transcription, initiation
C2U47_RS11425	COG3806	Anti-sigma factor
C2U47_RS11430	COG1968	undecaprenyl-diphosphatase activity
C2U47_RS11435	COG0667	Aldo Keto reductase
C2U47_RS11440	COG2017	converts alpha-aldose to the beta-anomer
C2U47_RS11445	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2U47_RS11455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U47_RS11460	COG1609	Transcriptional regulator
C2U47_RS11465	COG3250	beta-galactosidase activity
C2U47_RS11505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U47_RS11515	COG1438	arginine binding
C2U47_RS11520	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C2U47_RS11525	COG0540	Belongs to the ATCase OTCase family
C2U47_RS11545	COG0583	DNA-binding transcription factor activity
C2U47_RS11565	COG3040	lipid binding
C2U47_RS11575	COG1979	alcohol dehydrogenase
C2U47_RS11580	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C2U47_RS11585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C2U47_RS11590	COG2964	Protein conserved in bacteria
C2U47_RS11595	COG3681	Belongs to the UPF0597 family
C2U47_RS11600	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U47_RS11605	COG0564	pseudouridine synthase activity
C2U47_RS11615	COG0542	response to heat
C2U47_RS11620	COG0583	DNA-binding transcription factor activity
C2U47_RS11635	COG2502	aspartate--ammonia ligase
C2U47_RS11640	COG1522	sequence-specific DNA binding
C2U47_RS11650	COG0516	GMP reductase activity
C2U47_RS11650	COG0517	IMP dehydrogenase activity
C2U47_RS11670	COG2205	protein histidine kinase activity
C2U47_RS11680	COG2204	response regulator
C2U47_RS11695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U47_RS11730	COG0243	molybdopterin cofactor binding
C2U47_RS11735	COG3005	denitrification pathway
C2U47_RS11740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U47_RS11750	COG0569	domain protein
C2U47_RS11755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2U47_RS11780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U47_RS11795	COG0250	Participates in transcription elongation, termination and antitermination
C2U47_RS11800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2U47_RS11805	COG0081	regulation of translation
C2U47_RS11810	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2U47_RS11815	COG0222	ribosome binding
C2U47_RS11820	COG0085	RNA polymerase activity
C2U47_RS11825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2U47_RS11830	COG2964	Protein conserved in bacteria
C2U47_RS11835	COG0251	oxidation-reduction process
C2U47_RS11840	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U47_RS11850	COG2168	tRNA wobble position uridine thiolation
C2U47_RS11855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U47_RS11860	COG0049	tRNA binding
C2U47_RS11865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U47_RS11870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U47_RS11875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U47_RS11910	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2U47_RS11915	COG2252	PERMEase
C2U47_RS11920	COG2376	Dihydroxyacetone kinase
C2U47_RS11925	COG1461	Dihydroxyacetone kinase
C2U47_RS11940	COG0583	DNA-binding transcription factor activity
C2U47_RS11945	COG2957	Belongs to the agmatine deiminase family
C2U47_RS11975	COG0628	permease
C2U47_RS11980	COG0494	nUDIX hydrolase
C2U47_RS12000	COG0753	catalase activity
C2U47_RS12005	COG0456	acetyltransferase
C2U47_RS12035	COG3842	ATPase activity
C2U47_RS12045	COG1175	transmembrane transport
C2U47_RS12070	COG0583	DNA-binding transcription factor activity
C2U47_RS12080	COG1741	Belongs to the pirin family
C2U47_RS12085	COG2259	Doxx family
C2U47_RS12090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2U47_RS12095	COG1074	ATP-dependent DNA helicase activity
C2U47_RS12100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U47_RS12120	COG0346	lactoylglutathione lyase activity
C2U47_RS12130	COG0004	ammonium transporteR
C2U47_RS12135	COG0347	Belongs to the P(II) protein family
C2U47_RS12140	COG3706	GGDEF domain
C2U47_RS12170	COG1278	Cold shock
C2U47_RS12195	COG1396	sequence-specific DNA binding
C2U47_RS12215	COG3039	Transposase
C2U47_RS12255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U47_RS12290	COG2197	response regulator
C2U47_RS12300	COG3047	cAMP biosynthetic process
C2U47_RS12330	COG3135	benzoate transporter
C2U47_RS12335	COG1396	sequence-specific DNA binding
C2U47_RS12365	COG2926	Belongs to the UPF0265 family
C2U47_RS12375	COG3028	Belongs to the UPF0307 family
C2U47_RS12380	COG0312	modulator of DNA gyrase
C2U47_RS12385	COG3071	HemY protein
C2U47_RS12390	COG2959	enzyme of heme biosynthesis
C2U47_RS12400	COG0181	hydroxymethylbilane synthase activity
C2U47_RS12405	COG3072	Adenylate cyclase
C2U47_RS12410	COG0400	carboxylic ester hydrolase activity
C2U47_RS12415	COG1965	Belongs to the frataxin family
C2U47_RS12425	COG0019	diaminopimelate decarboxylase activity
C2U47_RS12430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2U47_RS12445	COG1011	Hydrolase
C2U47_RS12455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2U47_RS12460	COG0561	phosphatase activity
C2U47_RS12475	COG1988	membrane-bound metal-dependent
C2U47_RS12480	COG1546	Belongs to the CinA family
C2U47_RS12480	COG1058	Belongs to the CinA family
C2U47_RS12490	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2U47_RS12500	COG1522	sequence-specific DNA binding
C2U47_RS12505	COG1368	sulfuric ester hydrolase activity
C2U47_RS12520	COG1285	pathogenesis
C2U47_RS12540	COG4221	oxidoreductase activity
C2U47_RS12555	COG1979	alcohol dehydrogenase
C2U47_RS12565	COG2873	o-acetylhomoserine
C2U47_RS12595	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2U47_RS12605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2U47_RS12610	COG2949	membrane
C2U47_RS12615	COG3291	Pkd domain containing protein
C2U47_RS12630	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2U47_RS12635	COG0596	Alpha beta hydrolase
C2U47_RS12640	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2U47_RS12645	COG1169	isochorismate synthase
C2U47_RS12650	COG1575	Belongs to the MenA family. Type 1 subfamily
C2U47_RS12670	COG0513	Belongs to the DEAD box helicase family
C2U47_RS12675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U47_RS12690	COG1671	Belongs to the UPF0178 family
C2U47_RS12710	COG3263	regulation of cellular component size
C2U47_RS12715	COG3722	fumarate hydratase activity
C2U47_RS12720	COG0246	Mannitol dehydrogenase
C2U47_RS12730	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C2U47_RS12740	COG3916	Acyl-homoserine-lactone synthase
C2U47_RS12745	COG2771	luxR family
C2U47_RS12760	COG1560	Kdo2-lipid A biosynthetic process
C2U47_RS12765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2U47_RS12765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2U47_RS12775	COG1538	Outer membrane efflux protein
C2U47_RS12780	COG0494	nUDIX hydrolase
C2U47_RS12785	COG3151	Protein conserved in bacteria
C2U47_RS12795	COG3150	esterase
C2U47_RS12800	COG1051	belongs to the nudix hydrolase family
C2U47_RS12815	COG1566	PFAM secretion protein HlyD family protein
C2U47_RS12820	COG1289	transmembrane transporter activity
C2U47_RS12865	COG0004	ammonium transporteR
C2U47_RS12870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U47_RS12880	COG2165	general secretion pathway protein
C2U47_RS12885	COG0084	hydrolase, TatD family'
C2U47_RS12890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U47_RS12900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2U47_RS12905	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2U47_RS12910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2U47_RS12920	COG4520	surface antigen
C2U47_RS12925	COG5001	Diguanylate cyclase
C2U47_RS12925	COG3447	MASE1 domain protein
C2U47_RS12925	COG5002	protein histidine kinase activity
C2U47_RS12935	COG0560	Phosphoserine phosphatase
C2U47_RS12950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2U47_RS12960	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
C2U47_RS12965	COG0776	regulation of translation
C2U47_RS12980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U47_RS12985	COG0735	belongs to the Fur family
C2U47_RS13005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2U47_RS13010	COG0513	Belongs to the DEAD box helicase family
C2U47_RS13015	COG3022	response to hydroperoxide
C2U47_RS13030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U47_RS13035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2U47_RS13040	COG0762	integral membrane protein
C2U47_RS13045	COG1872	DUF167
C2U47_RS13070	COG3835	regulator
C2U47_RS13075	COG2610	gluconate transmembrane transporter activity
C2U47_RS13080	COG1929	Belongs to the glycerate kinase type-1 family
C2U47_RS13095	COG0583	DNA-binding transcription factor activity
C2U47_RS13100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2U47_RS13115	COG0347	Belongs to the P(II) protein family
C2U47_RS13130	COG3842	ATPase activity
C2U47_RS13135	COG2837	iron assimilation
C2U47_RS13140	COG1438	arginine binding
C2U47_RS13145	COG1126	abc transporter atp-binding protein
C2U47_RS13150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_RS13155	COG4215	(ABC) transporter
C2U47_RS13160	COG4160	amino acid transport
C2U47_RS13165	COG0039	L-malate dehydrogenase activity
C2U47_RS13175	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C2U47_RS13180	COG1017	nitric oxide dioxygenase activity
C2U47_RS13180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U47_RS13190	COG4536	flavin adenine dinucleotide binding
C2U47_RS13195	COG4137	Cytochrome C assembly protein
C2U47_RS13200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U47_RS13205	COG0228	four-way junction DNA binding
C2U47_RS13210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U47_RS13215	COG0336	Belongs to the RNA methyltransferase TrmD family
C2U47_RS13220	COG0335	large ribosomal subunit rRNA binding
C2U47_RS13245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2U47_RS13250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2U47_RS13255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U47_RS13265	COG0583	DNA-binding transcription factor activity
C2U47_RS13270	COG0640	Transcriptional regulator
C2U47_RS13275	COG0268	Binds directly to 16S ribosomal RNA
C2U47_RS13280	COG0728	peptidoglycan biosynthetic process
C2U47_RS13285	COG0196	riboflavin kinase activity
C2U47_RS13290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U47_RS13295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2U47_RS13300	COG1047	Peptidyl-prolyl cis-trans
C2U47_RS13305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2U47_RS13360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U47_RS13360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2U47_RS13375	COG1854	S-ribosylhomocysteine lyase activity
C2U47_RS13380	COG3706	GGDEF domain
C2U47_RS13385	COG0557	exoribonuclease II activity
C2U47_RS13390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U47_RS13400	COG2153	protein acetylation
C2U47_RS13410	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U47_RS13415	COG0360	Binds together with S18 to 16S ribosomal RNA
C2U47_RS13420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2U47_RS13425	COG0359	binds to the 23S rRNA
C2U47_RS13465	COG1238	metal cluster binding
C2U47_RS13470	COG0612	Peptidase, M16
C2U47_RS13475	COG2918	glutathione biosynthetic process
C2U47_RS13480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U47_RS13485	COG1027	Aspartate ammonia-lyase
C2U47_RS13490	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2U47_RS13495	COG0534	Mate efflux family protein
C2U47_RS13500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2U47_RS13505	COG0459	protein refolding
C2U47_RS13525	COG0564	pseudouridine synthase activity
C2U47_RS13530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2U47_RS13560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2U47_RS13570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2U47_RS13575	COG4208	sulfate ABC transporter
C2U47_RS13580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U47_RS13585	COG0583	DNA-binding transcription factor activity
C2U47_RS13590	COG3397	chitin binding
C2U47_RS13595	COG0840	transmembrane signaling receptor activity
C2U47_RS13620	COG1328	CTP reductase activity
C2U47_RS13625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U47_RS13635	COG0583	DNA-binding transcription factor activity
C2U47_RS13640	COG1448	Aminotransferase
C2U47_RS13645	COG2194	sulfuric ester hydrolase activity
C2U47_RS13665	COG1215	transferase activity, transferring glycosyl groups
C2U47_RS13675	COG3118	belongs to the thioredoxin family
C2U47_RS13675	COG0457	Tetratricopeptide repeat
C2U47_RS13710	COG0513	Belongs to the DEAD box helicase family
C2U47_RS13715	COG0840	transmembrane signaling receptor activity
C2U47_RS13725	COG4166	transmembrane transport
C2U47_RS13740	COG1024	Enoyl-CoA hydratase
C2U47_RS13755	COG4221	oxidoreductase activity
C2U47_RS13760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U47_RS13765	COG0442	prolyl-tRNA aminoacylation
C2U47_RS13770	COG0840	transmembrane signaling receptor activity
C2U47_RS13775	COG0632	four-way junction helicase activity
C2U47_RS13780	COG2255	four-way junction helicase activity
C2U47_RS13785	COG1271	oxidase subunit
C2U47_RS13790	COG1294	oxidase, subunit
C2U47_RS13795	COG4890	Cyd operon protein YbgT
C2U47_RS13800	COG3790	cyd operon protein YbgE
C2U47_RS13805	COG0824	Thioesterase
C2U47_RS13810	COG0811	peptide transport
C2U47_RS13825	COG0823	Involved in the tonB-independent uptake of proteins
C2U47_RS13830	COG2885	chlorophyll binding
C2U47_RS13835	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C2U47_RS13910	COG0840	transmembrane signaling receptor activity
C2U47_RS13915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2U47_RS13925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U47_RS13930	COG1640	4-alpha-glucanotransferase
C2U47_RS13935	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2U47_RS13965	COG2130	NADP-dependent
C2U47_RS13970	COG1846	Transcriptional regulator
C2U47_RS14000	COG0561	phosphatase activity
C2U47_RS14015	COG0733	neurotransmitter:sodium symporter activity
C2U47_RS14020	COG0733	neurotransmitter:sodium symporter activity
C2U47_RS14035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U47_RS14050	COG1794	racemase activity, acting on amino acids and derivatives
C2U47_RS14060	COG1022	Amp-dependent synthetase and ligase
C2U47_RS14070	COG0456	acetyltransferase
C2U47_RS14090	COG5001	Diguanylate cyclase
C2U47_RS14090	COG5002	protein histidine kinase activity
C2U47_RS14100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C2U47_RS14110	COG0456	acetyltransferase
C2U47_RS14120	COG0456	acetyltransferase
C2U47_RS14125	COG1902	pentaerythritol trinitrate reductase activity
C2U47_RS14135	COG2852	Protein conserved in bacteria
C2U47_RS14145	COG2957	Belongs to the agmatine deiminase family
C2U47_RS14150	COG0154	amidase activity
C2U47_RS14160	COG2801	Transposase and inactivated derivatives
C2U47_RS14185	COG1917	Cupin 2, conserved barrel domain protein
C2U47_RS14185	COG2207	Transcriptional regulator
C2U47_RS14195	COG0513	Belongs to the DEAD box helicase family
C2U47_RS14200	COG2199	diguanylate cyclase activity
C2U47_RS14200	COG2203	Gaf domain
C2U47_RS14235	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C2U47_RS14245	COG0577	efflux transmembrane transporter activity
C2U47_RS14245	COG1136	(ABC) transporter
C2U47_RS14250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_RS14255	COG0745	RESPONSE REGULATOR receiver
C2U47_RS14260	COG2205	protein histidine kinase activity
C2U47_RS14310	COG1280	lysine exporter protein (LysE YggA)
C2U47_RS14315	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2U47_RS14330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U47_RS14360	COG0745	RESPONSE REGULATOR receiver
C2U47_RS14365	COG3104	oligopeptide transport
C2U47_RS14370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2U47_RS14375	COG1555	photosystem II stabilization
C2U47_RS14385	COG2350	Protein conserved in bacteria
C2U47_RS14390	COG2917	probably involved in intracellular septation
C2U47_RS14395	COG0076	glutamate decarboxylase activity
C2U47_RS14400	COG1272	protein, Hemolysin III
C2U47_RS14405	COG2985	domain, Protein
C2U47_RS14405	COG0569	domain protein
C2U47_RS14425	COG0477	Major facilitator Superfamily
C2U47_RS14430	COG0583	DNA-binding transcription factor activity
C2U47_RS14435	COG3227	Zinc metalloprotease (Elastase)
C2U47_RS14440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U47_RS14445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U47_RS14455	COG2731	YhcH YjgK YiaL family protein
C2U47_RS14465	COG0668	transmembrane transport
C2U47_RS14475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U47_RS14490	COG0789	Transcriptional regulator
C2U47_RS14500	COG3039	Transposase
C2U47_RS14530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U47_RS14540	COG0488	(ABC) transporter
C2U47_RS14545	COG0516	GMP reductase activity
C2U47_RS14545	COG0517	IMP dehydrogenase activity
C2U47_RS14555	COG0784	Response regulator, receiver
C2U47_RS14555	COG0835	chemotaxis
C2U47_RS14560	COG2755	lipolytic protein G-D-S-L family
C2U47_RS14565	COG4181	ATPase activity
C2U47_RS14570	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U47_RS14575	COG1090	epimerase
C2U47_RS14580	COG2200	EAL domain
C2U47_RS14585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U47_RS14590	COG4935	Belongs to the peptidase S8 family
C2U47_RS14590	COG2234	aminopeptidase activity
C2U47_RS14595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U47_RS14600	COG3171	Protein conserved in bacteria
C2U47_RS14605	COG2066	Belongs to the glutaminase family
C2U47_RS14610	COG2897	thiosulfate sulfurtransferase activity
C2U47_RS14625	COG1132	(ABC) transporter
C2U47_RS14650	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C2U47_RS14655	COG5001	Diguanylate cyclase
C2U47_RS14655	COG3300	MHYT domain
C2U47_RS14675	COG4628	conserved protein (DUF2132)
C2U47_RS14680	COG0688	phosphatidylethanolamine metabolic process
C2U47_RS14685	COG1162	GTPase activity
C2U47_RS14690	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U47_RS14730	COG1278	Cold shock
C2U47_RS14740	COG0840	transmembrane signaling receptor activity
C2U47_RS14745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U47_RS14750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U47_RS14815	COG0848	biopolymer transport protein
C2U47_RS14820	COG0811	peptide transport
C2U47_RS14825	COG0811	peptide transport
C2U47_RS14835	COG4206	TonB-dependent receptor
C2U47_RS14840	COG4174	ABC transporter (Permease)
C2U47_RS14845	COG4239	(ABC) transporter, permease
C2U47_RS14855	COG0444	Belongs to the ABC transporter superfamily
C2U47_RS14860	COG4608	Belongs to the ABC transporter superfamily
C2U47_RS14870	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U47_RS14880	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2U47_RS14885	COG1073	alpha beta
C2U47_RS14900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2U47_RS14925	COG0243	molybdopterin cofactor binding
C2U47_RS14930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U47_RS14930	COG1648	precorrin-2 dehydrogenase activity
C2U47_RS14945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U47_RS14950	COG1116	anion transmembrane transporter activity
C2U47_RS14955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U47_RS14955	COG2146	nitrite reductase [NAD(P)H] activity
C2U47_RS14960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U47_RS14960	COG2146	nitrite reductase [NAD(P)H] activity
C2U47_RS14965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U47_RS14970	COG2313	pseudouridylate synthase activity
C2U47_RS14990	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U47_RS15000	COG2966	Psort location CytoplasmicMembrane, score
C2U47_RS15005	COG3610	response to peptide
C2U47_RS15015	COG4175	Glycine betaine
C2U47_RS15020	COG4176	ABC-type proline glycine betaine transport system permease component
C2U47_RS15025	COG2113	Glycine betaine
C2U47_RS15030	COG0175	sulfate reduction
C2U47_RS15035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U47_RS15050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2U47_RS15065	COG0786	glutamate:sodium symporter activity
C2U47_RS15070	COG0252	asparaginase activity
C2U47_RS15075	COG3139	Protein of unknown function (DUF1315)
C2U47_RS15095	COG0616	signal peptide processing
C2U47_RS15100	COG1902	pentaerythritol trinitrate reductase activity
C2U47_RS15100	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U47_RS15105	COG0778	Nitroreductase
C2U47_RS15115	COG0110	maltose O-acetyltransferase activity
C2U47_RS15120	COG2264	protein methyltransferase activity
C2U47_RS15125	COG0604	alcohol dehydrogenase
C2U47_RS15130	COG0583	DNA-binding transcription factor activity
C2U47_RS15135	COG1263	PTS System
C2U47_RS15135	COG2190	(PTS) system
C2U47_RS15135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_RS15140	COG4145	pantothenate transmembrane transporter activity
C2U47_RS15145	COG3924	membrane
C2U47_RS15150	COG0439	Biotin carboxylase
C2U47_RS15155	COG0511	ligase activity, forming carbon-carbon bonds
C2U47_RS15160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2U47_RS15165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U47_RS15180	COG3381	protein complex oligomerization
C2U47_RS15195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U47_RS15205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2U47_RS15210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U47_RS15210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U47_RS15225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2U47_RS15230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U47_RS15235	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2U47_RS15240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2U47_RS15245	COG4172	Belongs to the ABC transporter superfamily
C2U47_RS15255	COG0601	transmembrane transport
C2U47_RS15260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U47_RS15265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2U47_RS15270	COG0142	geranyltranstransferase activity
C2U47_RS15275	COG1722	exodeoxyribonuclease VII activity
C2U47_RS15280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U47_RS15285	COG1360	Flagellar Motor Protein
C2U47_RS15300	COG1534	Rna-binding protein
C2U47_RS15305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2U47_RS15315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2U47_RS15320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U47_RS15325	COG0149	triose-phosphate isomerase activity
C2U47_RS15330	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U47_RS15345	COG0779	Required for maturation of 30S ribosomal subunits
C2U47_RS15350	COG0195	Participates in both transcription termination and antitermination
C2U47_RS15355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2U47_RS15360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U47_RS15365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U47_RS15370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2U47_RS15375	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U47_RS15380	COG2211	Major facilitator Superfamily
C2U47_RS15385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C2U47_RS15390	COG1422	Protein of unknown function (DUF1090)
C2U47_RS15405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U47_RS15410	COG0826	peptidase U32
C2U47_RS15425	COG0312	modulator of DNA gyrase
C2U47_RS15435	COG0312	modulator of DNA gyrase
C2U47_RS15445	COG4974	Belongs to the 'phage' integrase family
C2U47_RS15450	COG1970	mechanosensitive ion channel activity
C2U47_RS15460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2U47_RS15465	COG0789	Transcriptional regulator
C2U47_RS15480	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C2U47_RS15490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U47_RS15495	COG0321	lipoyl(octanoyl) transferase activity
C2U47_RS15500	COG2921	Belongs to the UPF0250 family
C2U47_RS15505	COG1686	Belongs to the peptidase S11 family
C2U47_RS15510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2U47_RS15515	COG2951	lytic endotransglycosylase activity
C2U47_RS15520	COG0772	Belongs to the SEDS family
C2U47_RS15525	COG0768	penicillin binding
C2U47_RS15530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2U47_RS15535	COG0799	negative regulation of ribosome biogenesis
C2U47_RS15540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2U47_RS15555	COG0495	leucyl-tRNA aminoacylation
C2U47_RS15560	COG2888	peptidyl-tyrosine sulfation
C2U47_RS15565	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2U47_RS15570	COG4535	Mg2 and Co2 transporter CorC
C2U47_RS15575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2U47_RS15580	COG1702	phosphate starvation-inducible protein PhoH
C2U47_RS15585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U47_RS15590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U47_RS15595	COG1335	isochorismatase
C2U47_RS15610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U47_RS15625	COG3706	GGDEF domain
C2U47_RS15635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U47_RS15650	COG1464	Belongs to the NlpA lipoprotein family
C2U47_RS15655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U47_RS15660	COG2011	ABC-type metal ion transport system permease component
C2U47_RS15665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U47_RS15675	COG0516	GMP reductase activity
C2U47_RS15680	COG4067	protein conserved in archaea
C2U47_RS15680	COG0189	ligase activity
C2U47_RS15700	COG0300	oxidoreductase activity
C2U47_RS15720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U47_RS15725	COG3214	Protein conserved in bacteria
C2U47_RS15740	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U47_RS15745	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C2U47_RS15750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U47_RS15755	COG1053	succinate dehydrogenase
C2U47_RS15765	COG0584	glycerophosphoryl diester phosphodiesterase
C2U47_RS15770	COG1511	domain protein
C2U47_RS15770	COG3264	Mechanosensitive ion channel
C2U47_RS15795	COG0583	DNA-binding transcription factor activity
C2U47_RS15810	COG0583	DNA-binding transcription factor activity
C2U47_RS15815	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2U47_RS15845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U47_RS15850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2U47_RS15860	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2U47_RS15865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U47_RS15870	COG0546	phosphoglycolate phosphatase activity
C2U47_RS15875	COG0180	Tryptophanyl-tRNA synthetase
C2U47_RS15890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U47_RS15900	COG1012	belongs to the aldehyde dehydrogenase family
C2U47_RS15915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U47_RS15940	COG0471	metal ion transport
C2U47_RS15940	COG0490	domain, Protein
C2U47_RS16005	COG3385	transposase activity
C2U47_RS16055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_RS16090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_RS16095	COG3041	Addiction module toxin RelE StbE family
C2U47_RS16110	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U47_RS16125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U47_RS16135	COG0583	DNA-binding transcription factor activity
C2U47_RS16145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U47_RS16150	COG0625	glutathione transferase activity
C2U47_RS16215	COG3385	transposase activity
C2U47_RS16240	COG1136	(ABC) transporter
C2U47_RS16255	COG1309	transcriptional regulator
C2U47_RS16265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U47_RS16270	COG1196	nuclear chromosome segregation
C2U47_RS16300	COG0582	viral genome integration into host DNA
C2U47_RS16305	COG0012	GTP binding
C2U47_RS16310	COG0193	aminoacyl-tRNA hydrolase activity
C2U47_RS16315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U47_RS16325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2U47_RS16330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2U47_RS16335	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2U47_RS16340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2U47_RS16355	COG2912	Transglutaminase-like superfamily
C2U47_RS16360	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2U47_RS16365	COG1301	dicarboxylic acid transport
C2U47_RS16375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2U47_RS16390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U47_RS16395	COG1115	amino acid carrier protein
C2U47_RS16415	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U47_RS16425	COG0189	ligase activity
C2U47_RS16430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U47_RS16440	COG3091	SprT-like family
C2U47_RS16450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U47_RS16475	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2U47_RS16480	COG0739	heme binding
C2U47_RS16485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U47_RS16495	COG1881	PFAM PEBP family protein
C2U47_RS16500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2U47_RS16505	COG0583	DNA-binding transcription factor activity
C2U47_RS16515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2U47_RS16525	COG0583	DNA-binding transcription factor activity
C2U47_RS16530	COG1028	Short-chain dehydrogenase reductase Sdr
C2U47_RS16535	COG0616	signal peptide processing
C2U47_RS16540	COG3724	N-succinylarginine dihydrolase activity
C2U47_RS16555	COG0840	transmembrane signaling receptor activity
C2U47_RS16565	COG2971	BadF BadG BcrA BcrD
C2U47_RS16575	COG4608	Belongs to the ABC transporter superfamily
C2U47_RS16585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U47_RS16600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U47_RS16660	COG0745	RESPONSE REGULATOR receiver
C2U47_RS16665	COG5002	protein histidine kinase activity
C2U47_RS16690	COG2132	Multicopper oxidase
C2U47_RS16705	COG3039	Transposase
C2U47_RS16715	COG3385	transposase activity
C2U47_RS16720	COG5642	Protein of unknown function (DUF2384)
C2U47_RS16725	COG0659	secondary active sulfate transmembrane transporter activity
C2U47_RS16740	COG1484	DNA-dependent DNA replication
C2U47_RS16745	COG4584	PFAM Integrase catalytic
C2U47_RS16780	COG1484	DNA-dependent DNA replication
C2U47_RS16820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2U47_RS16830	COG0732	type I restriction modification DNA specificity domain
C2U47_RS16855	COG3039	Transposase
C2U47_RS16875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U47_RS16890	COG0758	DNA mediated transformation
C2U47_RS16895	COG0514	ATP-dependent DNA helicase (RecQ)
C2U47_RS16945	COG3039	Transposase
C2U47_RS16965	COG5002	protein histidine kinase activity
C2U47_RS16965	COG5001	Diguanylate cyclase
C2U47_RS16965	COG3447	MASE1 domain protein
C2U47_RS16995	COG0640	Transcriptional regulator
C2U47_RS17000	COG0798	PFAM Bile acid sodium symporter
C2U47_RS17005	COG1393	Belongs to the ArsC family
C2U47_RS17015	COG1677	Flagellar hook-basal body complex protein FliE
C2U47_RS17025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U47_RS17080	COG1684	flagellar biosynthetic protein fliR
C2U47_RS17090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U47_RS17115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2U47_RS17120	COG0784	Response regulator, receiver
C2U47_RS17120	COG0643	Histidine kinase
C2U47_RS17120	COG2198	Histidine kinase
C2U47_RS17130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2U47_RS17135	COG1360	Flagellar Motor Protein
C2U47_RS17140	COG1192	Involved in chromosome partitioning
C2U47_RS17150	COG0835	chemotaxis
C2U47_RS17165	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U47_RS17170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U47_RS17175	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U47_RS17180	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2U47_RS17185	COG1138	Cytochrome C-type biogenesis protein
C2U47_RS17190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U47_RS17200	COG0457	Tetratricopeptide repeat
C2U47_RS17215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U47_RS17220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U47_RS17220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U47_RS17235	COG0259	pyridoxamine-phosphate oxidase activity
C2U47_RS17265	COG3153	acetyltransferase
C2U47_RS17280	COG0800	Aldolase
C2U47_RS17285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U47_RS17300	COG0246	Mannitol dehydrogenase
C2U47_RS17360	COG3039	Transposase
C2U47_RS17395	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U47_RS17410	COG5642	Protein of unknown function (DUF2384)
C2U47_RS17415	COG2850	peptidyl-arginine hydroxylation
C2U47_RS17440	COG0210	DNA helicase
C2U47_RS17470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2U47_RS17475	COG2867	negative regulation of translational initiation
C2U47_RS17480	COG2914	Belongs to the UPF0125 (RnfH) family
C2U47_RS17485	COG0702	epimerase
C2U47_RS17490	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U47_RS17495	COG1454	alcohol dehydrogenase
C2U47_RS17510	COG1957	nucleoside hydrolase
C2U47_RS17535	COG1280	lysine exporter protein (LysE YggA)
C2U47_RS17545	COG3263	regulation of cellular component size
C2U47_RS17555	COG1876	peptidase activity
C2U47_RS17560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U47_RS17565	COG1393	Belongs to the ArsC family
C2U47_RS17575	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U47_RS17580	COG1473	amidohydrolase
C2U47_RS17590	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2U47_RS17595	COG0017	Asparaginyl-tRNA synthetase
C2U47_RS17615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U47_RS17620	COG0156	8-amino-7-oxononanoate synthase activity
C2U47_RS17625	COG1073	alpha beta
C2U47_RS17625	COG2226	methyltransferase
C2U47_RS17630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2U47_RS17635	COG0501	Belongs to the peptidase M48B family
C2U47_RS17650	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2U47_RS17650	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2U47_RS17650	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U47_RS17650	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2U47_RS17655	COG2841	Protein conserved in bacteria
C2U47_RS17665	COG0534	Mate efflux family protein
C2U47_RS17690	COG1454	alcohol dehydrogenase
C2U47_RS17700	COG1309	transcriptional regulator
C2U47_RS17715	COG0791	NLP P60 protein
C2U47_RS17720	COG0583	DNA-binding transcription factor activity
C2U47_RS17740	COG0500	methyltransferase
C2U47_RS17745	COG4106	trans-aconitate 2-methyltransferase activity
C2U47_RS17750	COG1801	Protein of unknown function DUF72
C2U47_RS17760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2U47_RS17765	COG0217	transcriptional regulatory protein
C2U47_RS17770	COG2194	sulfuric ester hydrolase activity
C2U47_RS17775	COG1940	carbohydrate kinase activity
C2U47_RS17775	COG1846	Transcriptional regulator
C2U47_RS17780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U47_RS17785	COG0363	glucosamine-6-phosphate deaminase activity
C2U47_RS17790	COG2190	(PTS) system
C2U47_RS17790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_RS17790	COG1263	PTS System
C2U47_RS17800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U47_RS17805	COG0735	belongs to the Fur family
C2U47_RS17815	COG0716	FMN binding
C2U47_RS17830	COG0596	Alpha beta hydrolase
C2U47_RS17835	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C2U47_RS17840	COG0033	Phosphoglucomutase
C2U47_RS17850	COG1846	Transcriptional regulator
C2U47_RS17855	COG2951	lytic endotransglycosylase activity
C2U47_RS17860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U47_RS17875	COG4134	Bacterial extracellular solute-binding protein
C2U47_RS17880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U47_RS17885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U47_RS17900	COG3039	Transposase
C2U47_RS17905	COG3039	Transposase
C2U47_RS17910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U47_RS17920	COG0729	surface antigen
C2U47_RS17945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U47_RS17955	COG0741	lytic transglycosylase activity
C2U47_RS17970	COG1607	acyl-coa hydrolase
C2U47_RS17985	COG0741	lytic transglycosylase activity
C2U47_RS17985	COG1388	LysM domain
C2U47_RS17990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U47_RS17995	COG2226	methyltransferase
C2U47_RS18000	COG0328	RNA-DNA hybrid ribonuclease activity
C2U47_RS18005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U47_RS18025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U47_RS18030	COG0121	glutamine amidotransferase
C2U47_RS18040	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2U47_RS18065	COG2197	response regulator
C2U47_RS18070	COG3850	Histidine kinase
C2U47_RS18075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U47_RS18080	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U47_RS18080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U47_RS18090	COG0243	molybdopterin cofactor binding
C2U47_RS18095	COG0437	4 iron, 4 sulfur cluster binding
C2U47_RS18110	COG3005	denitrification pathway
C2U47_RS18115	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U47_RS18120	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U47_RS18125	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2U47_RS18130	COG0314	molybdopterin synthase activity
C2U47_RS18145	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2U47_RS18150	COG2267	carboxylic ester hydrolase activity
C2U47_RS18155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U47_RS18160	COG0303	'Molybdopterin
C2U47_RS18165	COG0302	gtp cyclohydrolase
C2U47_RS18170	COG0840	transmembrane signaling receptor activity
C2U47_RS18175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C2U47_RS18185	COG0583	DNA-binding transcription factor activity
C2U47_RS18200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2U47_RS18215	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U47_RS18225	COG1166	arginine decarboxylase activity
C2U47_RS18255	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2U47_RS18280	COG3385	transposase activity
C2U47_RS18295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U47_RS18300	COG1187	pseudouridine synthase activity
C2U47_RS18315	COG0583	DNA-binding transcription factor activity
C2U47_RS18335	COG2979	Protein of unknown function (DUF533)
C2U47_RS18345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U47_RS18355	COG1294	oxidase, subunit
C2U47_RS18365	COG2814	Major facilitator Superfamily
C2U47_RS18370	COG0656	L-ascorbic acid biosynthetic process
C2U47_RS18390	COG0583	DNA-binding transcription factor activity
C2U47_RS18395	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2U47_RS18400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2U47_RS18405	COG2271	Major facilitator Superfamily
C2U47_RS18410	COG1349	DNA-binding transcription factor activity
C2U47_RS18420	COG0584	glycerophosphoryl diester phosphodiesterase
C2U47_RS18425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U47_RS18430	COG0287	Prephenate dehydrogenase
C2U47_RS18430	COG1605	Chorismate mutase
C2U47_RS18440	COG3085	chromosome segregation
C2U47_RS18445	COG4574	serine-type endopeptidase inhibitor activity
C2U47_RS18465	COG1770	oligopeptidase
C2U47_RS18470	COG4771	TonB-dependent receptor
C2U47_RS18475	COG3083	sulfuric ester hydrolase activity
C2U47_RS18480	COG3082	Protein of unknown function (DUF1414)
C2U47_RS18485	COG3081	Nucleoid-associated protein
C2U47_RS18495	COG1175	transmembrane transport
C2U47_RS18500	COG3833	ABC-type maltose transport systems, permease component
C2U47_RS18505	COG3842	ATPase activity
C2U47_RS18515	COG0596	Alpha beta hydrolase
C2U47_RS18520	COG3385	transposase activity
C2U47_RS18535	COG0425	Belongs to the sulfur carrier protein TusA family
C2U47_RS18540	COG4783	chaperone-mediated protein folding
C2U47_RS18550	COG1393	Belongs to the ArsC family
C2U47_RS18565	COG0675	Transposase, IS605 OrfB family
C2U47_RS18575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_RS18580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2U47_RS18585	COG2431	L-lysine efflux transmembrane transporter activity
C2U47_RS18595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U47_RS18605	COG4160	amino acid transport
C2U47_RS18615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2U47_RS18625	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U47_RS18630	COG2373	Large extracellular alpha-helical protein
C2U47_RS18635	COG4953	penicillin-binding protein 1C
C2U47_RS18645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U47_RS18645	COG0301	tRNA thio-modification
C2U47_RS18660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2U47_RS18665	COG1334	flagellar protein FlaG
C2U47_RS18700	COG2089	acid synthase
C2U47_RS18710	COG1083	cytidylyl-transferase
C2U47_RS18745	COG1216	Glycosyl transferase, family 2
C2U47_RS18800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U47_RS18810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2U47_RS18815	COG1086	Polysaccharide biosynthesis protein
C2U47_RS18820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U47_RS18830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U47_RS18850	COG0675	Transposase, IS605 OrfB family
C2U47_RS18860	COG0346	lactoylglutathione lyase activity
C2U47_RS18870	COG4660	Part of a membrane complex involved in electron transport
C2U47_RS18875	COG4659	FMN binding
C2U47_RS18880	COG4658	electron transport chain
C2U47_RS18890	COG2878	Part of a membrane complex involved in electron transport
C2U47_RS18895	COG4657	Part of a membrane complex involved in electron transport
C2U47_RS18900	COG0675	Transposase, IS605 OrfB family
C2U47_RS18905	COG5433	transposase activity
C2U47_RS18910	COG3039	Transposase
C2U47_RS18955	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U47_RS18960	COG1288	antiporter activity
C2U47_RS18965	COG0436	Aminotransferase
C2U47_RS18975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U47_RS18985	COG1061	Type III restriction enzyme res subunit
C2U47_RS18990	COG1566	PFAM secretion protein HlyD family protein
C2U47_RS19005	COG0675	Transposase, IS605 OrfB family
C2U47_RS19015	COG1966	Carbon starvation protein
C2U47_RS19020	COG3279	Response regulator of the LytR AlgR family
C2U47_RS19035	COG1454	alcohol dehydrogenase
C2U47_RS19035	COG1012	belongs to the aldehyde dehydrogenase family
C2U47_RS19040	COG2095	MarC family integral membrane protein
C2U47_RS19055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U47_RS19060	COG0444	Belongs to the ABC transporter superfamily
C2U47_RS19070	COG0861	Integral membrane protein TerC family
C2U47_RS19075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U47_RS19085	COG1301	dicarboxylic acid transport
C2U47_RS19105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U47_RS19120	COG0537	adenosine 5'-monophosphoramidase activity
C2U47_RS19155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U47_RS19160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U47_RS19175	COG2354	Protein conserved in bacteria
C2U47_RS19180	COG1164	Oligoendopeptidase f
C2U47_RS19185	COG1164	Oligoendopeptidase f
C2U47_RS19190	COG3150	esterase
C2U47_RS19195	COG1252	NADH dehydrogenase
C2U47_RS19200	COG0393	Putative heavy-metal-binding
C2U47_RS19215	COG0527	aspartate kinase activity
C2U47_RS19220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U47_RS19220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U47_RS19225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U47_RS19250	COG0583	DNA-binding transcription factor activity
C2U47_RS19255	COG1620	l-lactate permease
C2U47_RS19260	COG0247	lactate metabolic process
C2U47_RS19265	COG1139	Iron-sulfur cluster binding protein
C2U47_RS19280	COG3039	Transposase
C2U47_RS19295	COG0577	efflux transmembrane transporter activity
C2U47_RS19300	COG1136	(ABC) transporter
C2U47_RS19320	COG2814	Major facilitator Superfamily
C2U47_RS19345	COG0672	)-iron permease
C2U47_RS19380	COG2308	Evidence 4 Homologs of previously reported genes of
C2U47_RS19415	COG0659	secondary active sulfate transmembrane transporter activity
C2U47_RS19430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U47_RS19435	COG3039	Transposase
C2U47_RS19440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2U47_RS19450	COG0326	Molecular chaperone. Has ATPase activity
C2U47_RS19455	COG0563	adenylate kinase activity
C2U47_RS19460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2U47_RS19465	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C2U47_RS19470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U47_RS19475	COG0840	transmembrane signaling receptor activity
C2U47_RS19515	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2U47_RS19520	COG1535	isochorismatase
C2U47_RS19520	COG3433	isochorismatase activity
C2U47_RS19525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U47_RS19530	COG1028	Short-chain dehydrogenase reductase Sdr
C2U47_RS19545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U47_RS19550	COG2977	Belongs to the P-Pant transferase superfamily
C2U47_RS19560	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U47_RS19565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U47_RS19570	COG4771	TonB-dependent receptor
C2U47_RS19610	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2U47_RS19615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U47_RS19620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U47_RS19625	COG0861	Integral membrane protein TerC family
C2U47_RS19640	COG1022	Amp-dependent synthetase and ligase
C2U47_RS19645	COG0295	cytidine deaminase activity
C2U47_RS19650	COG1346	cytolysis
C2U47_RS19655	COG1380	Effector of murein hydrolase LrgA
C2U47_RS19660	COG3345	alpha-galactosidase
C2U47_RS19670	COG2925	Exonuclease
C2U47_RS19675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U47_RS19695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U47_RS19700	COG0436	Aminotransferase
C2U47_RS19705	COG0583	DNA-binding transcription factor activity
C2U47_RS19710	COG2160	L-arabinose isomerase activity
C2U47_RS19720	COG1069	ribulokinase activity
C2U47_RS19725	COG1879	ABC-type sugar transport system periplasmic component
C2U47_RS19730	COG1129	ABC transporter
C2U47_RS19735	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U47_RS19745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U47_RS19750	COG0254	rRNA binding
C2U47_RS19765	COG1451	nucleotide metabolic process
C2U47_RS19780	COG3069	C4-dicarboxylate transmembrane transporter activity
C2U47_RS19790	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2U47_RS19790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U47_RS19795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U47_RS19815	COG2009	succinate dehydrogenase
C2U47_RS19820	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U47_RS19835	COG0567	Dehydrogenase, E1 component
C2U47_RS19840	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U47_RS19845	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U47_RS19850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U47_RS19855	COG2801	Transposase and inactivated derivatives
C2U47_RS19870	COG2983	Belongs to the UPF0260 family
C2U47_RS19880	COG1882	Formate acetyltransferase
C2U47_RS19885	COG2116	formate transmembrane transporter activity
C2U47_RS19890	COG1944	ATP diphosphatase activity
C2U47_RS19900	COG2076	Multidrug Resistance protein
C2U47_RS19905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U47_RS19910	COG1278	Cold shock
C2U47_RS19915	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U47_RS19920	COG0542	response to heat
C2U47_RS19925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U47_RS19930	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2U47_RS19935	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U47_RS19940	COG3134	Outer membrane lipoprotein
C2U47_RS19945	COG3706	GGDEF domain
C2U47_RS19950	COG0492	ferredoxin-NADP+ reductase activity
C2U47_RS19955	COG0686	Belongs to the AlaDH PNT family
C2U47_RS19965	COG1674	ftsk spoiiie
C2U47_RS19965	COG0531	amino acid
C2U47_RS19970	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U47_RS19975	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U47_RS19980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2U47_RS19985	COG1286	toxin biosynthetic process
C2U47_RS19990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2U47_RS19995	COG2723	6-phospho-beta-galactosidase activity
C2U47_RS20000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_RS20000	COG1263	PTS System
C2U47_RS20005	COG1609	Transcriptional regulator
C2U47_RS20015	COG4172	Belongs to the ABC transporter superfamily
C2U47_RS20025	COG4171	peptide transport system, permease
C2U47_RS20040	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2U47_RS20045	COG1842	Phage shock protein A
C2U47_RS20060	COG3106	COG3106 Predicted ATPase
C2U47_RS20065	COG3768	UPF0283 membrane protein
C2U47_RS20075	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2U47_RS20090	COG2199	diguanylate cyclase activity
C2U47_RS20095	COG2885	chlorophyll binding
C2U47_RS20105	COG1570	exodeoxyribonuclease VII activity
C2U47_RS20125	COG0517	IMP dehydrogenase activity
C2U47_RS20125	COG0516	GMP reductase activity
C2U47_RS20130	COG0519	Catalyzes the synthesis of GMP from XMP
C2U47_RS20130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U47_RS20135	COG3039	Transposase
C2U47_RS20165	COG1846	Transcriptional regulator
C2U47_RS20185	COG2062	phosphohistidine phosphatase, SixA
C2U47_RS20195	COG0697	spore germination
C2U47_RS20205	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2U47_RS20210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U47_RS20220	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U47_RS20225	COG1136	(ABC) transporter
C2U47_RS20230	COG4591	ABC-type transport system involved in lipoprotein release permease component
C2U47_RS20235	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C2U47_RS20250	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2U47_RS20255	COG0740	serine-type endopeptidase activity
C2U47_RS20260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2U47_RS20265	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U47_RS20270	COG0776	regulation of translation
C2U47_RS20275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U47_RS20280	COG0488	(ABC) transporter
C2U47_RS20285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U47_RS20290	COG3162	membrane
C2U47_RS20305	COG1024	Enoyl-CoA hydratase
C2U47_RS20310	COG1115	amino acid carrier protein
C2U47_RS20320	COG3228	Belongs to the MtfA family
C2U47_RS20325	COG1584	GPR1 FUN34 yaaH family protein
C2U47_RS20350	COG1024	Enoyl-CoA hydratase
C2U47_RS20355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U47_RS20360	COG1960	acyl-CoA dehydrogenase activity
C2U47_RS20370	COG1960	acyl-CoA dehydrogenase activity
C2U47_RS20375	COG1024	Enoyl-CoA hydratase
C2U47_RS20380	COG1024	Enoyl-CoA hydratase
C2U47_RS20390	COG1028	Short-chain dehydrogenase reductase Sdr
C2U47_RS20400	COG0730	response to heat
C2U47_RS20430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_RS20470	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U47_RS20475	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U47_RS20480	COG1129	ABC transporter
C2U47_RS20485	COG1879	ABC-type sugar transport system periplasmic component
C2U47_RS20490	COG0583	DNA-binding transcription factor activity
C2U47_RS20505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U47_RS20510	COG0243	molybdopterin cofactor binding
C2U47_RS20520	COG0583	DNA-binding transcription factor activity
C2U47_RS20525	COG2723	6-phospho-beta-galactosidase activity
C2U47_RS20535	COG0583	DNA-binding transcription factor activity
C2U47_RS20550	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2U47_RS20555	COG0673	inositol 2-dehydrogenase activity
C2U47_RS20560	COG0583	DNA-binding transcription factor activity
C2U47_RS20570	COG1560	Kdo2-lipid A biosynthetic process
C2U47_RS20575	COG1560	Kdo2-lipid A biosynthetic process
C2U47_RS20590	COG0417	DNA replication proofreading
C2U47_RS20620	COG0534	Mate efflux family protein
C2U47_RS20630	COG0307	riboflavin synthase, alpha
C2U47_RS20645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U47_RS20650	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2U47_RS20655	COG0697	spore germination
C2U47_RS20660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U47_RS20690	COG0675	Transposase, IS605 OrfB family
C2U47_RS20695	COG2996	Protein conserved in bacteria
C2U47_RS20715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U47_RS20720	COG3099	Belongs to the UPF0263 family
C2U47_RS20725	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2U47_RS20730	COG2894	cell division
C2U47_RS20735	COG0850	regulation of cytokinetic process
C2U47_RS20740	COG3100	YcgL domain-containing protein
C2U47_RS20745	COG2951	lytic endotransglycosylase activity
C2U47_RS20750	COG1760	l-serine dehydratase
C2U47_RS20760	COG1760	l-serine dehydratase
C2U47_RS20765	COG3123	guanosine phosphorylase activity
C2U47_RS20770	COG1301	dicarboxylic acid transport
C2U47_RS20785	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2U47_RS20790	COG2067	long-chain fatty acid transport protein
C2U47_RS20795	COG2067	long-chain fatty acid transport protein
C2U47_RS20805	COG1595	DNA-templated transcription, initiation
C2U47_RS20835	COG0714	Associated with various cellular activities
C2U47_RS20840	COG0183	Belongs to the thiolase family
C2U47_RS20855	COG4681	YaeQ
C2U47_RS20875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U47_RS20890	COG3134	Outer membrane lipoprotein
C2U47_RS20895	COG0318	PFAM AMP-dependent synthetase and ligase
C2U47_RS20915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U47_RS20915	COG0140	phosphoribosyl-ATP diphosphatase activity
C2U47_RS20920	COG0107	imidazoleglycerol-phosphate synthase activity
C2U47_RS20935	COG3437	response regulator, receiver
C2U47_RS20940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2U47_RS20945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2U47_RS20950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U47_RS20950	COG0131	Imidazoleglycerol-phosphate dehydratase
C2U47_RS20955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U47_RS20960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U47_RS20965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2U47_RS20980	COG1214	PFAM Peptidase M22, glycoprotease
C2U47_RS20990	COG0596	Alpha beta hydrolase
C2U47_RS20995	COG0318	PFAM AMP-dependent synthetase and ligase
C2U47_RS21020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U47_RS21025	COG2832	Protein of unknown function (DUF454)
C2U47_RS21030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2U47_RS21040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2U47_RS21045	COG0583	DNA-binding transcription factor activity
C2U47_RS21055	COG3314	Sporulation integral membrane protein YlbJ
C2U47_RS21060	COG2197	response regulator
C2U47_RS21065	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2U47_RS21065	COG0617	tRNA 3'-terminal CCA addition
C2U47_RS21065	COG0517	IMP dehydrogenase activity
C2U47_RS21070	COG1643	Atp-dependent helicase
C2U47_RS21080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2U47_RS21095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U47_RS21100	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2U47_RS21105	COG0709	Synthesizes selenophosphate from selenide and ATP
C2U47_RS21120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U47_RS21125	COG0840	transmembrane signaling receptor activity
C2U47_RS21130	COG1254	Belongs to the acylphosphatase family
C2U47_RS21140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U47_RS21140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U47_RS21145	COG0489	protein tyrosine kinase activity
C2U47_RS21150	COG0572	uridine kinase
C2U47_RS21155	COG0717	Belongs to the dCTP deaminase family
C2U47_RS21160	COG0306	phosphate transporter
C2U47_RS21165	COG1530	ribonuclease E activity
C2U47_RS21170	COG0564	pseudouridine synthase activity
C2U47_RS21185	COG1399	metal-binding, possibly nucleic acid-binding protein
C2U47_RS21190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2U47_RS21195	COG0416	fatty acid biosynthetic process
C2U47_RS21200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U47_RS21210	COG1028	Short-chain dehydrogenase reductase Sdr
C2U47_RS21215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U47_RS21220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U47_RS21225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U47_RS21230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U47_RS21235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2U47_RS21240	COG0470	DNA polymerase III
C2U47_RS21245	COG0084	hydrolase, TatD family'
C2U47_RS21260	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C2U47_RS21260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U47_RS21265	COG3008	intermembrane lipid transfer
C2U47_RS21270	COG2995	paraquat-inducible protein a
C2U47_RS21280	COG3141	response to X-ray
C2U47_RS21290	COG1067	ATP-dependent peptidase activity
C2U47_RS21295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U47_RS21310	COG0488	(ABC) transporter
C2U47_RS21320	COG0116	Belongs to the methyltransferase superfamily
C2U47_RS21320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2U47_RS21330	COG0167	dihydroorotate dehydrogenase activity
C2U47_RS21345	COG0308	aminopeptidase N
C2U47_RS21355	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C2U47_RS21360	COG1956	GAF domain-containing protein
C2U47_RS21370	COG3278	Belongs to the heme-copper respiratory oxidase family
C2U47_RS21385	COG2010	Cytochrome c
C2U47_RS21395	COG2217	Heavy metal translocating P-type atpase
C2U47_RS21410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U47_RS21415	COG0589	response to stress
C2U47_RS21420	COG0037	tRNA processing
C2U47_RS21435	COG0625	glutathione transferase activity
C2U47_RS21440	COG1869	D-ribose catabolic process
C2U47_RS21445	COG1129	ABC transporter
C2U47_RS21450	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U47_RS21455	COG1879	ABC-type sugar transport system periplasmic component
C2U47_RS21460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U47_RS21465	COG1609	Transcriptional regulator
C2U47_RS21510	COG0776	regulation of translation
C2U47_RS21515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U47_RS21515	COG0072	phenylalanine-tRNA ligase activity
C2U47_RS21520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2U47_RS21525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2U47_RS21530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U47_RS21535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2U47_RS21540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2U47_RS21565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U47_RS21575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U47_RS21580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U47_RS21585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U47_RS21590	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2U47_RS21595	COG3313	Fe-S protein
C2U47_RS21600	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2U47_RS21600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U47_RS21600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U47_RS21605	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U47_RS21610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U47_RS21610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U47_RS21615	COG1609	Transcriptional regulator
C2U47_RS21620	COG0814	amino acid
C2U47_RS21630	COG5654	RES domain protein
C2U47_RS21640	COG0513	Belongs to the DEAD box helicase family
C2U47_RS21650	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2U47_RS21655	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U47_RS21660	COG2840	Smr protein MutS2
C2U47_RS21695	COG2824	Alkylphosphonate utilization operon protein PhnA
C2U47_RS21760	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2U47_RS21765	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C2U47_RS21775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U47_RS21780	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2U47_RS21790	COG0205	6-phosphofructokinase activity
C2U47_RS21805	COG1473	amidohydrolase
C2U47_RS21810	COG1011	Hydrolase
C2U47_RS21815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U47_RS21855	COG3593	DNA synthesis involved in DNA repair
C2U47_RS21870	COG0583	DNA-binding transcription factor activity
C2U47_RS21875	COG0730	response to heat
C2U47_RS21880	COG3148	PFAM DTW domain containing protein
C2U47_RS21885	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U47_RS21895	COG0386	Belongs to the glutathione peroxidase family
C2U47_RS21900	COG0513	Belongs to the DEAD box helicase family
C2U47_RS21935	COG2329	Antibiotic biosynthesis monooxygenase
C2U47_RS21940	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2U47_RS21960	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U47_RS21970	COG2501	S4 domain
C2U47_RS21990	COG1132	(ABC) transporter
C2U47_RS22005	COG3118	belongs to the thioredoxin family
C2U47_RS22010	COG0471	metal ion transport
C2U47_RS22025	COG0058	SHG alpha-glucan phosphorylase activity
C2U47_RS22055	COG0814	amino acid
C2U47_RS22060	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C2U47_RS22080	COG2766	serine protein kinase
C2U47_RS22085	COG2718	Belongs to the UPF0229 family
C2U47_RS22090	COG2719	SpoVR family
C2U47_RS22095	COG2186	Transcriptional regulator
C2U47_RS22100	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2U47_RS22105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U47_RS22110	COG0586	Pfam SNARE associated Golgi protein
C2U47_RS22120	COG0556	nucleotide-excision repair
C2U47_RS22135	COG0569	domain protein
C2U47_RS22135	COG2985	domain, Protein
C2U47_RS22140	COG1196	nuclear chromosome segregation
C2U47_RS22140	COG0739	heme binding
C2U47_RS22140	COG0741	lytic transglycosylase activity
C2U47_RS22145	COG3181	Tripartite tricarboxylate transporter family receptor
C2U47_RS22160	COG4565	transcriptional regulatory protein
C2U47_RS22165	COG3290	protein histidine kinase activity
C2U47_RS22170	COG1940	carbohydrate kinase activity
C2U47_RS22170	COG1846	Transcriptional regulator
C2U47_RS22175	COG0840	transmembrane signaling receptor activity
C2U47_RS22180	COG3012	SEC-C Motif Domain Protein
C2U47_RS22185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2U47_RS22190	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C2U47_RS22205	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C2U47_RS22210	COG0437	4 iron, 4 sulfur cluster binding
C2U47_RS22220	COG1138	Cytochrome C-type biogenesis protein
C2U47_RS22225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U47_RS22230	COG3088	subunit of a heme lyase
C2U47_RS22230	COG4235	cytochrome complex assembly
C2U47_RS22245	COG3046	protein related to deoxyribodipyrimidine photolyase
C2U47_RS22250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U47_RS22265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2U47_RS22265	COG0617	tRNA 3'-terminal CCA addition
C2U47_RS22265	COG0517	IMP dehydrogenase activity
C2U47_RS22275	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2U47_RS22280	COG0583	DNA-binding transcription factor activity
C2U47_RS22295	COG2203	Gaf domain
C2U47_RS22295	COG2199	diguanylate cyclase activity
C2U47_RS22300	COG2200	EAL domain
C2U47_RS22305	COG4977	sequence-specific DNA binding
C2U47_RS22305	COG1917	Cupin 2, conserved barrel domain protein
C2U47_RS22310	COG0583	DNA-binding transcription factor activity
C2U47_RS22315	COG2910	NAD(P)H-binding
C2U47_RS22325	COG0626	cystathionine gamma-synthase activity
C2U47_RS22330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2U47_RS22350	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2U47_RS22365	COG2723	6-phospho-beta-galactosidase activity
C2U47_RS22370	COG1263	PTS System
C2U47_RS22370	COG2190	(PTS) system
C2U47_RS22370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2U47_RS22375	COG1737	Transcriptional regulator
C2U47_RS22400	COG1435	thymidine kinase activity
C2U47_RS22405	COG1757	Na H antiporter
C2U47_RS22410	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2U47_RS22415	COG2096	Adenosyltransferase
C2U47_RS22420	COG3530	Putative quorum-sensing-regulated virulence factor
C2U47_RS22425	COG0602	queuosine metabolic process
C2U47_RS22430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U47_RS22450	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2U47_RS22460	COG0776	regulation of translation
C2U47_RS22465	COG0539	negative regulation of cytoplasmic translation
C2U47_RS22470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2U47_RS22475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U47_RS22505	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C2U47_RS22540	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U47_RS22560	COG1280	lysine exporter protein (LysE YggA)
C2U47_RS22600	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U47_RS22625	COG3093	addiction module antidote protein HigA
C2U47_RS22720	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C2U47_RS22735	COG3736	Type IV secretory pathway, component VirB8
C2U47_RS22760	COG3451	type IV secretory pathway VirB4