locus-tag	class	description
I6L49_RS00010	COG0583	DNA-binding transcription factor activity
I6L49_RS00015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6L49_RS00045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6L49_RS00050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6L49_RS00060	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6L49_RS00065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L49_RS00075	COG0180	Tryptophanyl-tRNA synthetase
I6L49_RS00090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L49_RS00100	COG1012	belongs to the aldehyde dehydrogenase family
I6L49_RS00115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L49_RS00125	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L49_RS00125	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L49_RS00125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L49_RS00125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L49_RS00130	COG0366	Alpha amylase catalytic
I6L49_RS00150	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6L49_RS00160	COG0471	metal ion transport
I6L49_RS00160	COG0490	domain, Protein
I6L49_RS00205	COG0012	GTP binding
I6L49_RS00210	COG0193	aminoacyl-tRNA hydrolase activity
I6L49_RS00215	COG0737	Belongs to the 5'-nucleotidase family
I6L49_RS00220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L49_RS00230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6L49_RS00235	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L49_RS00240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6L49_RS00245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6L49_RS00250	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L49_RS00260	COG2912	Transglutaminase-like superfamily
I6L49_RS00265	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6L49_RS00270	COG1301	dicarboxylic acid transport
I6L49_RS00285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6L49_RS00295	COG3408	Glycogen debranching enzyme
I6L49_RS00295	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6L49_RS00305	COG1881	PFAM PEBP family protein
I6L49_RS00310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L49_RS00325	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L49_RS00335	COG0583	DNA-binding transcription factor activity
I6L49_RS00340	COG1028	Short-chain dehydrogenase reductase Sdr
I6L49_RS00345	COG0616	signal peptide processing
I6L49_RS00350	COG2211	Major facilitator Superfamily
I6L49_RS00355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L49_RS00365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L49_RS00370	COG0826	peptidase U32
I6L49_RS00375	COG2200	EAL domain
I6L49_RS00375	COG2203	Gaf domain
I6L49_RS00375	COG2199	diguanylate cyclase activity
I6L49_RS00390	COG3188	usher protein
I6L49_RS00400	COG2197	response regulator
I6L49_RS00430	COG3724	N-succinylarginine dihydrolase activity
I6L49_RS00450	COG0840	transmembrane signaling receptor activity
I6L49_RS00460	COG2971	BadF BadG BcrA BcrD
I6L49_RS00470	COG4608	Belongs to the ABC transporter superfamily
I6L49_RS00475	COG0444	Belongs to the ABC transporter superfamily
I6L49_RS00480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L49_RS00495	COG2205	protein histidine kinase activity
I6L49_RS00495	COG0784	Response regulator, receiver
I6L49_RS00535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L49_RS00540	COG1289	transmembrane transporter activity
I6L49_RS00545	COG0303	'Molybdopterin
I6L49_RS00550	COG0746	molybdenum cofactor guanylyltransferase activity
I6L49_RS00560	COG4662	Binding-protein-dependent transport system inner membrane component
I6L49_RS00570	COG2204	response regulator
I6L49_RS00575	COG3852	Histidine kinase
I6L49_RS00585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L49_RS00620	COG3383	formate dehydrogenase (NAD+) activity
I6L49_RS00620	COG3383	formate dehydrogenase (NAD+) activity
I6L49_RS00625	COG0437	4 iron, 4 sulfur cluster binding
I6L49_RS00645	COG0281	malic enzyme
I6L49_RS00665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L49_RS00695	COG0837	glucose binding
I6L49_RS00700	COG1737	Transcriptional regulator
I6L49_RS00705	COG0469	pyruvate kinase activity
I6L49_RS00725	COG1677	Flagellar hook-basal body complex protein FliE
I6L49_RS00735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L49_RS00785	COG1987	bacterial-type flagellum assembly
I6L49_RS00790	COG1684	flagellar biosynthetic protein fliR
I6L49_RS00800	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6L49_RS00825	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6L49_RS00830	COG0643	Histidine kinase
I6L49_RS00830	COG0784	Response regulator, receiver
I6L49_RS00830	COG2198	Histidine kinase
I6L49_RS00840	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L49_RS00845	COG1360	Flagellar Motor Protein
I6L49_RS00850	COG1192	Involved in chromosome partitioning
I6L49_RS00860	COG0835	chemotaxis
I6L49_RS00875	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L49_RS00880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L49_RS00885	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L49_RS00890	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6L49_RS00895	COG1138	Cytochrome C-type biogenesis protein
I6L49_RS00900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L49_RS00905	COG3088	subunit of a heme lyase
I6L49_RS00905	COG4235	cytochrome complex assembly
I6L49_RS00915	COG2853	Lipoprotein
I6L49_RS00925	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L49_RS00930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L49_RS00940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L49_RS00945	COG1882	Formate acetyltransferase
I6L49_RS00955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L49_RS00955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L49_RS00985	COG0259	pyridoxamine-phosphate oxidase activity
I6L49_RS01010	COG2850	peptidyl-arginine hydroxylation
I6L49_RS01015	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L49_RS01020	COG2915	High frequency lysogenization protein hflD homolog
I6L49_RS01025	COG0482	sulfurtransferase activity
I6L49_RS01030	COG1051	belongs to the nudix hydrolase family
I6L49_RS01035	COG1187	pseudouridine synthase activity
I6L49_RS01045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L49_RS01050	COG2271	Major facilitator Superfamily
I6L49_RS01055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L49_RS01055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L49_RS01055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L49_RS01060	COG1204	response to ionizing radiation
I6L49_RS01075	COG1609	Transcriptional regulator
I6L49_RS01080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L49_RS01080	COG1263	PTS System
I6L49_RS01085	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L49_RS01095	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6L49_RS01105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L49_RS01110	COG1960	acyl-CoA dehydrogenase activity
I6L49_RS01120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6L49_RS01130	COG1940	carbohydrate kinase activity
I6L49_RS01135	COG0457	Tetratricopeptide repeat
I6L49_RS01140	COG2814	Major facilitator Superfamily
I6L49_RS01140	COG0477	Major facilitator Superfamily
I6L49_RS01150	COG3383	formate dehydrogenase (NAD+) activity
I6L49_RS01160	COG2205	protein histidine kinase activity
I6L49_RS01160	COG0784	Response regulator, receiver
I6L49_RS01220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6L49_RS01225	COG2867	negative regulation of translational initiation
I6L49_RS01230	COG2914	Belongs to the UPF0125 (RnfH) family
I6L49_RS01235	COG1473	amidohydrolase
I6L49_RS01240	COG1960	acyl-CoA dehydrogenase activity
I6L49_RS01245	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L49_RS01250	COG0121	glutamine amidotransferase
I6L49_RS01280	COG2197	response regulator
I6L49_RS01285	COG3850	Histidine kinase
I6L49_RS01290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L49_RS01295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L49_RS01305	COG0243	molybdopterin cofactor binding
I6L49_RS01310	COG0437	4 iron, 4 sulfur cluster binding
I6L49_RS01315	COG0348	domain, Protein
I6L49_RS01325	COG3005	denitrification pathway
I6L49_RS01330	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L49_RS01335	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L49_RS01340	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6L49_RS01345	COG0314	molybdopterin synthase activity
I6L49_RS01360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L49_RS01365	COG2267	carboxylic ester hydrolase activity
I6L49_RS01370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L49_RS01380	COG0302	gtp cyclohydrolase
I6L49_RS01385	COG0840	transmembrane signaling receptor activity
I6L49_RS01390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6L49_RS01400	COG0583	DNA-binding transcription factor activity
I6L49_RS01405	COG2353	YceI-like domain
I6L49_RS01415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L49_RS01430	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L49_RS01435	COG1166	arginine decarboxylase activity
I6L49_RS01445	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6L49_RS01465	COG0814	amino acid
I6L49_RS01475	COG3681	Belongs to the UPF0597 family
I6L49_RS01480	COG2964	Protein conserved in bacteria
I6L49_RS01490	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L49_RS01495	COG1288	antiporter activity
I6L49_RS01500	COG0436	Aminotransferase
I6L49_RS01510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L49_RS01515	COG0741	lytic transglycosylase activity
I6L49_RS01515	COG0739	heme binding
I6L49_RS01515	COG1196	nuclear chromosome segregation
I6L49_RS01530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L49_RS01540	COG0788	formyltetrahydrofolate deformylase activity
I6L49_RS01545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L49_RS01565	COG0791	NLP P60 protein
I6L49_RS01570	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6L49_RS01580	COG0471	metal ion transport
I6L49_RS01590	COG1388	LysM domain
I6L49_RS01590	COG1376	ErfK ybiS ycfS ynhG family protein
I6L49_RS01600	COG0582	viral genome integration into host DNA
I6L49_RS01610	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6L49_RS01615	COG0732	type I restriction modification DNA specificity domain
I6L49_RS01620	COG1401	restriction endodeoxyribonuclease activity
I6L49_RS01620	COG1401	restriction endodeoxyribonuclease activity
I6L49_RS01630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6L49_RS01650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L49_RS01675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L49_RS01680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L49_RS01685	COG0745	RESPONSE REGULATOR receiver
I6L49_RS01690	COG5002	protein histidine kinase activity
I6L49_RS01690	COG5000	phosphorelay sensor kinase activity
I6L49_RS01715	COG1388	LysM domain
I6L49_RS01715	COG0741	lytic transglycosylase activity
I6L49_RS01720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L49_RS01725	COG2226	methyltransferase
I6L49_RS01730	COG0328	RNA-DNA hybrid ribonuclease activity
I6L49_RS01735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L49_RS01745	COG0784	Response regulator, receiver
I6L49_RS01745	COG3437	response regulator, receiver
I6L49_RS01750	COG2375	cellular response to nickel ion
I6L49_RS01755	COG4771	TonB-dependent receptor
I6L49_RS01760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L49_RS01765	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L49_RS01770	COG1120	ATPase activity
I6L49_RS01775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L49_RS01785	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L49_RS01790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L49_RS01825	COG0708	Exodeoxyribonuclease III
I6L49_RS01860	COG3132	Protein of unknown function, DUF480
I6L49_RS01865	COG5001	Diguanylate cyclase
I6L49_RS01865	COG3300	MHYT domain
I6L49_RS01875	COG2841	Protein conserved in bacteria
I6L49_RS01885	COG0534	Mate efflux family protein
I6L49_RS01915	COG1309	transcriptional regulator
I6L49_RS01955	COG3152	Membrane
I6L49_RS01970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L49_RS01975	COG0840	transmembrane signaling receptor activity
I6L49_RS01980	COG1482	cell wall glycoprotein biosynthetic process
I6L49_RS01985	COG2207	Transcriptional regulator
I6L49_RS01990	COG0538	isocitrate dehydrogenase activity
I6L49_RS02000	COG3048	D-serine ammonia-lyase activity
I6L49_RS02005	COG2610	gluconate transmembrane transporter activity
I6L49_RS02010	COG0583	DNA-binding transcription factor activity
I6L49_RS02020	COG0791	NLP P60 protein
I6L49_RS02025	COG0583	DNA-binding transcription factor activity
I6L49_RS02030	COG0450	alkyl hydroperoxide reductase
I6L49_RS02050	COG0500	methyltransferase
I6L49_RS02055	COG4106	trans-aconitate 2-methyltransferase activity
I6L49_RS02060	COG1801	Protein of unknown function DUF72
I6L49_RS02070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6L49_RS02075	COG0217	transcriptional regulatory protein
I6L49_RS02090	COG1012	belongs to the aldehyde dehydrogenase family
I6L49_RS02090	COG1454	alcohol dehydrogenase
I6L49_RS02095	COG2095	MarC family integral membrane protein
I6L49_RS02105	COG0601	transmembrane transport
I6L49_RS02110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L49_RS02125	COG0861	Integral membrane protein TerC family
I6L49_RS02130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L49_RS02160	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6L49_RS02165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L49_RS02170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6L49_RS02180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L49_RS02185	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6L49_RS02190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L49_RS02205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6L49_RS02210	COG0505	Belongs to the CarA family
I6L49_RS02215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L49_RS02225	COG1605	Chorismate mutase
I6L49_RS02225	COG0287	Prephenate dehydrogenase
I6L49_RS02230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L49_RS02240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L49_RS02245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L49_RS02280	COG0537	adenosine 5'-monophosphoramidase activity
I6L49_RS02295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6L49_RS02310	COG1301	dicarboxylic acid transport
I6L49_RS02315	COG0840	transmembrane signaling receptor activity
I6L49_RS02330	COG2354	Protein conserved in bacteria
I6L49_RS02340	COG2233	PERMEase
I6L49_RS02345	COG3150	esterase
I6L49_RS02350	COG1252	NADH dehydrogenase
I6L49_RS02360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L49_RS02365	COG3300	MHYT domain
I6L49_RS02365	COG5001	Diguanylate cyclase
I6L49_RS02370	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L49_RS02380	COG2373	Large extracellular alpha-helical protein
I6L49_RS02385	COG4953	penicillin-binding protein 1C
I6L49_RS02400	COG0301	tRNA thio-modification
I6L49_RS02400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L49_RS02415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L49_RS02420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L49_RS02460	COG2089	acid synthase
I6L49_RS02470	COG1083	cytidylyl-transferase
I6L49_RS02485	COG1028	Short-chain dehydrogenase reductase Sdr
I6L49_RS02490	COG0318	PFAM AMP-dependent synthetase and ligase
I6L49_RS02505	COG1215	transferase activity, transferring glycosyl groups
I6L49_RS02510	COG0562	UDP-galactopyranose mutase
I6L49_RS02545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L49_RS02550	COG0367	asparagine synthase
I6L49_RS02560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L49_RS02565	COG1086	Polysaccharide biosynthesis protein
I6L49_RS02580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L49_RS02595	COG0483	inositol monophosphate 1-phosphatase activity
I6L49_RS02605	COG0625	glutathione transferase activity
I6L49_RS02610	COG2814	Major facilitator Superfamily
I6L49_RS02630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L49_RS02635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L49_RS02645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6L49_RS02650	COG0509	glycine decarboxylation via glycine cleavage system
I6L49_RS02655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L49_RS02655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L49_RS02660	COG0840	transmembrane signaling receptor activity
I6L49_RS02690	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6L49_RS02695	COG0574	Belongs to the PEP-utilizing enzyme family
I6L49_RS02695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L49_RS02710	COG1464	Belongs to the NlpA lipoprotein family
I6L49_RS02715	COG3083	sulfuric ester hydrolase activity
I6L49_RS02720	COG3082	Protein of unknown function (DUF1414)
I6L49_RS02725	COG3081	Nucleoid-associated protein
I6L49_RS02735	COG1175	transmembrane transport
I6L49_RS02740	COG3833	ABC-type maltose transport systems, permease component
I6L49_RS02745	COG3842	ATPase activity
I6L49_RS02775	COG4783	chaperone-mediated protein folding
I6L49_RS02785	COG1393	Belongs to the ArsC family
I6L49_RS02795	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6L49_RS02805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L49_RS02810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L49_RS02815	COG2431	L-lysine efflux transmembrane transporter activity
I6L49_RS02825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L49_RS02835	COG4160	amino acid transport
I6L49_RS02840	COG0564	pseudouridine synthase activity
I6L49_RS02855	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6L49_RS02865	COG0625	glutathione transferase activity
I6L49_RS02890	COG0642	Histidine kinase
I6L49_RS02895	COG2261	transglycosylase associated protein
I6L49_RS02910	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L49_RS02920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L49_RS02925	COG0215	cysteine-tRNA ligase activity
I6L49_RS02970	COG2119	membrane
I6L49_RS02975	COG0023	Translation Initiation Factor
I6L49_RS03000	COG0513	Belongs to the DEAD box helicase family
I6L49_RS03010	COG0493	'glutamate synthase
I6L49_RS03015	COG0067	glutamate synthase
I6L49_RS03015	COG0069	glutamate synthase activity
I6L49_RS03015	COG0070	glutamate synthase
I6L49_RS03020	COG1242	4 iron, 4 sulfur cluster binding
I6L49_RS03085	COG3634	alkyl hydroperoxide reductase activity
I6L49_RS03095	COG0517	IMP dehydrogenase activity
I6L49_RS03100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6L49_RS03105	COG0343	queuine tRNA-ribosyltransferase activity
I6L49_RS03110	COG1862	Preprotein translocase
I6L49_RS03115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L49_RS03120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L49_RS03135	COG0826	peptidase U32
I6L49_RS03140	COG0826	peptidase U32
I6L49_RS03145	COG3154	lipid carrier protein
I6L49_RS03165	COG1104	cysteine desulfurase activity
I6L49_RS03170	COG0822	iron-sulfur transferase activity
I6L49_RS03180	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L49_RS03185	COG0443	Heat shock 70 kDa protein
I6L49_RS03190	COG0633	Ferredoxin
I6L49_RS03205	COG0105	UTP biosynthetic process
I6L49_RS03210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6L49_RS03225	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6L49_RS03230	COG0124	histidyl-tRNA synthetase
I6L49_RS03235	COG2976	Protein conserved in bacteria
I6L49_RS03240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L49_RS03245	COG1160	GTP binding
I6L49_RS03250	COG1645	bacterial-type flagellum-dependent swarming motility
I6L49_RS03255	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L49_RS03260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L49_RS03260	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L49_RS03265	COG2199	diguanylate cyclase activity
I6L49_RS03265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L49_RS03280	COG1007	ATP synthesis coupled electron transport
I6L49_RS03285	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L49_RS03295	COG0713	ATP synthesis coupled electron transport
I6L49_RS03300	COG0839	Belongs to the complex I subunit 6 family
I6L49_RS03305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L49_RS03310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6L49_RS03315	COG1034	ATP synthesis coupled electron transport
I6L49_RS03330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L49_RS03330	COG0649	NAD binding
I6L49_RS03335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L49_RS03340	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L49_RS03360	COG1770	oligopeptidase
I6L49_RS03365	COG4771	TonB-dependent receptor
I6L49_RS03370	COG1360	Flagellar Motor Protein
I6L49_RS03375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L49_RS03390	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L49_RS03400	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6L49_RS03405	COG4597	amino acid ABC transporter
I6L49_RS03410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L49_RS03415	COG0765	amino acid transport
I6L49_RS03420	COG1126	abc transporter atp-binding protein
I6L49_RS03430	COG0724	RNA recognition motif
I6L49_RS03435	COG4989	oxidoreductase activity
I6L49_RS03460	COG3437	response regulator, receiver
I6L49_RS03465	COG0583	DNA-binding transcription factor activity
I6L49_RS03470	COG5001	Diguanylate cyclase
I6L49_RS03470	COG3300	MHYT domain
I6L49_RS03475	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6L49_RS03495	COG2814	Major facilitator Superfamily
I6L49_RS03510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L49_RS03515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6L49_RS03520	COG0539	negative regulation of cytoplasmic translation
I6L49_RS03525	COG0776	regulation of translation
I6L49_RS03535	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6L49_RS03555	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L49_RS03560	COG0602	queuosine metabolic process
I6L49_RS03565	COG3530	Putative quorum-sensing-regulated virulence factor
I6L49_RS03570	COG2096	Adenosyltransferase
I6L49_RS03575	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L49_RS03580	COG1757	Na H antiporter
I6L49_RS03585	COG1435	thymidine kinase activity
I6L49_RS03725	COG4584	PFAM Integrase catalytic
I6L49_RS03730	COG1484	DNA-dependent DNA replication
I6L49_RS03770	COG2197	response regulator
I6L49_RS03775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L49_RS03775	COG2205	protein histidine kinase activity
I6L49_RS03785	COG2801	Transposase and inactivated derivatives
I6L49_RS03790	COG0745	RESPONSE REGULATOR receiver
I6L49_RS03810	COG0582	viral genome integration into host DNA
I6L49_RS03825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L49_RS03830	COG0326	Molecular chaperone. Has ATPase activity
I6L49_RS03835	COG4172	Belongs to the ABC transporter superfamily
I6L49_RS03840	COG4172	Belongs to the ABC transporter superfamily
I6L49_RS03850	COG4168	peptide transport system, permease
I6L49_RS03860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6L49_RS03865	COG1842	Phage shock protein A
I6L49_RS03880	COG3106	COG3106 Predicted ATPase
I6L49_RS03885	COG3768	UPF0283 membrane protein
I6L49_RS03890	COG0583	DNA-binding transcription factor activity
I6L49_RS03895	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L49_RS03900	COG3842	ATPase activity
I6L49_RS03905	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L49_RS03910	COG1177	transmembrane transport
I6L49_RS03915	COG1012	belongs to the aldehyde dehydrogenase family
I6L49_RS03925	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6L49_RS03945	COG2199	diguanylate cyclase activity
I6L49_RS03950	COG2885	chlorophyll binding
I6L49_RS03955	COG0861	Integral membrane protein TerC family
I6L49_RS03985	COG2910	NAD(P)H-binding
I6L49_RS03990	COG0583	DNA-binding transcription factor activity
I6L49_RS03995	COG0583	DNA-binding transcription factor activity
I6L49_RS04010	COG1335	isochorismatase
I6L49_RS04020	COG0583	DNA-binding transcription factor activity
I6L49_RS04025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L49_RS04035	COG0583	DNA-binding transcription factor activity
I6L49_RS04040	COG2723	6-phospho-beta-galactosidase activity
I6L49_RS04045	COG1944	ATP diphosphatase activity
I6L49_RS04050	COG2116	formate transmembrane transporter activity
I6L49_RS04055	COG1882	Formate acetyltransferase
I6L49_RS04060	COG2983	Belongs to the UPF0260 family
I6L49_RS04075	COG0058	SHG alpha-glucan phosphorylase activity
I6L49_RS04080	COG0471	metal ion transport
I6L49_RS04085	COG3118	belongs to the thioredoxin family
I6L49_RS04095	COG1132	(ABC) transporter
I6L49_RS04100	COG1132	(ABC) transporter
I6L49_RS04110	COG2501	S4 domain
I6L49_RS04125	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L49_RS04175	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L49_RS04180	COG1053	succinate dehydrogenase
I6L49_RS04190	COG0567	Dehydrogenase, E1 component
I6L49_RS04195	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L49_RS04200	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L49_RS04215	COG1584	GPR1 FUN34 yaaH family protein
I6L49_RS04245	COG1024	Enoyl-CoA hydratase
I6L49_RS04250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L49_RS04255	COG1960	acyl-CoA dehydrogenase activity
I6L49_RS04260	COG1960	acyl-CoA dehydrogenase activity
I6L49_RS04265	COG1024	Enoyl-CoA hydratase
I6L49_RS04270	COG1024	Enoyl-CoA hydratase
I6L49_RS04280	COG1028	Short-chain dehydrogenase reductase Sdr
I6L49_RS04290	COG0730	response to heat
I6L49_RS04300	COG2205	protein histidine kinase activity
I6L49_RS04300	COG0784	Response regulator, receiver
I6L49_RS04340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L49_RS04345	COG1215	transferase activity, transferring glycosyl groups
I6L49_RS04350	COG0438	transferase activity, transferring glycosyl groups
I6L49_RS04400	COG0438	transferase activity, transferring glycosyl groups
I6L49_RS04420	COG0438	transferase activity, transferring glycosyl groups
I6L49_RS04425	COG0438	transferase activity, transferring glycosyl groups
I6L49_RS04430	COG5001	Diguanylate cyclase
I6L49_RS04430	COG4251	negative regulation of phosphorylation
I6L49_RS04430	COG3706	GGDEF domain
I6L49_RS04430	COG2203	Gaf domain
I6L49_RS04435	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L49_RS04440	COG3437	response regulator, receiver
I6L49_RS04455	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6L49_RS04460	COG0437	4 iron, 4 sulfur cluster binding
I6L49_RS04465	COG5557	Pfam Polysulphide reductase, NrfD
I6L49_RS04470	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6L49_RS04475	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L49_RS04480	COG1773	rubredoxin
I6L49_RS04495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L49_RS04500	COG0444	Belongs to the ABC transporter superfamily
I6L49_RS04505	COG1124	(ABC) transporter
I6L49_RS04510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6L49_RS04515	COG0375	protein maturation
I6L49_RS04520	COG0309	Hydrogenase expression formation protein (HypE)
I6L49_RS04530	COG0298	carbon dioxide binding
I6L49_RS04535	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6L49_RS04545	COG1921	L-seryl-tRNASec selenium transferase activity
I6L49_RS04555	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L49_RS04565	COG3260	NADH ubiquinone oxidoreductase 20
I6L49_RS04570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L49_RS04575	COG3261	NADH dehydrogenase
I6L49_RS04575	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6L49_RS04580	COG0650	Formate hydrogenlyase subunit 4
I6L49_RS04585	COG0651	ATP synthesis coupled electron transport
I6L49_RS04590	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L49_RS04595	COG3158	transport of potassium into the cell
I6L49_RS04620	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L49_RS04645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L49_RS04650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L49_RS04655	COG3046	protein related to deoxyribodipyrimidine photolyase
I6L49_RS04665	COG3033	Beta-eliminating lyase
I6L49_RS04670	COG0295	cytidine deaminase activity
I6L49_RS04675	COG1346	cytolysis
I6L49_RS04680	COG1380	Effector of murein hydrolase LrgA
I6L49_RS04685	COG3345	alpha-galactosidase
I6L49_RS04695	COG2925	Exonuclease
I6L49_RS04700	COG0641	radical SAM
I6L49_RS04725	COG2304	oxidoreductase activity
I6L49_RS04730	COG2304	oxidoreductase activity
I6L49_RS04745	COG0714	Associated with various cellular activities
I6L49_RS04750	COG3119	arylsulfatase activity
I6L49_RS04755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L49_RS04760	COG0517	IMP dehydrogenase activity
I6L49_RS04760	COG0617	tRNA 3'-terminal CCA addition
I6L49_RS04760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L49_RS04765	COG1643	Atp-dependent helicase
I6L49_RS04775	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6L49_RS04790	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6L49_RS04795	COG2067	long-chain fatty acid transport protein
I6L49_RS04800	COG2067	long-chain fatty acid transport protein
I6L49_RS04810	COG1595	DNA-templated transcription, initiation
I6L49_RS04820	COG2304	oxidoreductase activity
I6L49_RS04840	COG0714	Associated with various cellular activities
I6L49_RS04845	COG0183	Belongs to the thiolase family
I6L49_RS04850	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L49_RS04850	COG1024	Enoyl-CoA hydratase
I6L49_RS04855	COG2719	SpoVR family
I6L49_RS04860	COG2718	Belongs to the UPF0229 family
I6L49_RS04865	COG2766	serine protein kinase
I6L49_RS04870	COG0514	ATP-dependent DNA helicase (RecQ)
I6L49_RS04875	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6L49_RS04880	COG0814	amino acid
I6L49_RS04900	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L49_RS04920	COG0406	alpha-ribazole phosphatase activity
I6L49_RS04925	COG3706	GGDEF domain
I6L49_RS04930	COG2840	Smr protein MutS2
I6L49_RS04935	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L49_RS04940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6L49_RS04950	COG0513	Belongs to the DEAD box helicase family
I6L49_RS04960	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6L49_RS04975	COG0814	amino acid
I6L49_RS04980	COG1609	Transcriptional regulator
I6L49_RS04985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L49_RS04985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L49_RS04990	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L49_RS04995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L49_RS04995	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L49_RS04995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L49_RS05000	COG1530	ribonuclease E activity
I6L49_RS05015	COG0424	maF-like protein
I6L49_RS05020	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L49_RS05025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6L49_RS05030	COG0416	fatty acid biosynthetic process
I6L49_RS05035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L49_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
I6L49_RS05050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L49_RS05055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L49_RS05060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L49_RS05065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L49_RS05070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L49_RS05075	COG0470	DNA polymerase III
I6L49_RS05080	COG0084	hydrolase, TatD family'
I6L49_RS05095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L49_RS05095	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6L49_RS05100	COG3008	intermembrane lipid transfer
I6L49_RS05105	COG2995	paraquat-inducible protein a
I6L49_RS05115	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6L49_RS05120	COG0372	Belongs to the citrate synthase family
I6L49_RS05165	COG4221	oxidoreductase activity
I6L49_RS05170	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L49_RS05175	COG3141	response to X-ray
I6L49_RS05340	COG1067	ATP-dependent peptidase activity
I6L49_RS05345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L49_RS05355	COG0488	(ABC) transporter
I6L49_RS05365	COG0116	Belongs to the methyltransferase superfamily
I6L49_RS05365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L49_RS05370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L49_RS05375	COG0254	rRNA binding
I6L49_RS05390	COG0167	dihydroorotate dehydrogenase activity
I6L49_RS05395	COG2902	Dehydrogenase
I6L49_RS05405	COG0308	aminopeptidase N
I6L49_RS05415	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6L49_RS05420	COG1956	GAF domain-containing protein
I6L49_RS05430	COG3278	Belongs to the heme-copper respiratory oxidase family
I6L49_RS05445	COG2010	Cytochrome c
I6L49_RS05455	COG2217	Heavy metal translocating P-type atpase
I6L49_RS05470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L49_RS05475	COG0589	response to stress
I6L49_RS05480	COG0037	tRNA processing
I6L49_RS05505	COG1177	transmembrane transport
I6L49_RS05525	COG0625	glutathione transferase activity
I6L49_RS05530	COG1869	D-ribose catabolic process
I6L49_RS05535	COG1129	ABC transporter
I6L49_RS05540	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L49_RS05545	COG1879	ABC-type sugar transport system periplasmic component
I6L49_RS05550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L49_RS05555	COG1609	Transcriptional regulator
I6L49_RS05560	COG3300	MHYT domain
I6L49_RS05560	COG5001	Diguanylate cyclase
I6L49_RS05585	COG0784	Response regulator, receiver
I6L49_RS05585	COG2205	protein histidine kinase activity
I6L49_RS05590	COG0776	regulation of translation
I6L49_RS05595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L49_RS05595	COG0072	phenylalanine-tRNA ligase activity
I6L49_RS05600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6L49_RS05605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6L49_RS05610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L49_RS05615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6L49_RS05620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6L49_RS05640	COG0366	Alpha amylase catalytic
I6L49_RS05650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L49_RS05660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L49_RS05665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L49_RS05670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L49_RS05675	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6L49_RS05680	COG3313	Fe-S protein
I6L49_RS05685	COG0306	phosphate transporter
I6L49_RS05690	COG0717	Belongs to the dCTP deaminase family
I6L49_RS05695	COG0572	uridine kinase
I6L49_RS05700	COG0489	protein tyrosine kinase activity
I6L49_RS05705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L49_RS05705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L49_RS05715	COG1254	Belongs to the acylphosphatase family
I6L49_RS05730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L49_RS05740	COG0709	Synthesizes selenophosphate from selenide and ATP
I6L49_RS05745	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6L49_RS05750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L49_RS05760	COG0318	PFAM AMP-dependent synthetase and ligase
I6L49_RS05765	COG2267	carboxylic ester hydrolase activity
I6L49_RS05775	COG1214	PFAM Peptidase M22, glycoprotease
I6L49_RS05780	COG1199	ATP-dependent helicase activity
I6L49_RS05790	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L49_RS05795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L49_RS05800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6L49_RS05805	COG0131	Imidazoleglycerol-phosphate dehydratase
I6L49_RS05805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L49_RS05810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L49_RS05815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6L49_RS05820	COG0107	imidazoleglycerol-phosphate synthase activity
I6L49_RS05830	COG4932	domain protein
I6L49_RS05830	COG5492	domain, Protein
I6L49_RS05835	COG2199	diguanylate cyclase activity
I6L49_RS05840	COG0318	PFAM AMP-dependent synthetase and ligase
I6L49_RS05850	COG3134	Outer membrane lipoprotein
I6L49_RS05855	COG2080	2 iron, 2 sulfur cluster binding
I6L49_RS05860	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L49_RS05865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L49_RS05870	COG2252	PERMEase
I6L49_RS05875	COG0402	S-adenosylhomocysteine deaminase activity
I6L49_RS05880	COG2233	PERMEase
I6L49_RS05885	COG2080	2 iron, 2 sulfur cluster binding
I6L49_RS05885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L49_RS05890	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L49_RS05895	COG0402	S-adenosylhomocysteine deaminase activity
I6L49_RS05900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L49_RS05900	COG0493	'glutamate synthase
I6L49_RS05910	COG2068	MobA-Related Protein
I6L49_RS05915	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L49_RS05920	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6L49_RS05920	COG3608	succinylglutamate desuccinylase aspartoacylase
I6L49_RS05930	COG0697	spore germination
I6L49_RS05935	COG0549	Belongs to the carbamate kinase family
I6L49_RS05945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L49_RS05950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L49_RS05955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L49_RS05985	COG0242	peptide deformylase activity
I6L49_RS06000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L49_RS06005	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L49_RS06010	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6L49_RS06020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L49_RS06025	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6L49_RS06035	COG0205	6-phosphofructokinase activity
I6L49_RS06045	COG3123	guanosine phosphorylase activity
I6L49_RS06050	COG1760	l-serine dehydratase
I6L49_RS06055	COG1760	l-serine dehydratase
I6L49_RS06060	COG3100	YcgL domain-containing protein
I6L49_RS06065	COG0850	regulation of cytokinetic process
I6L49_RS06070	COG2894	cell division
I6L49_RS06075	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6L49_RS06080	COG3099	Belongs to the UPF0263 family
I6L49_RS06085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L49_RS06125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L49_RS06130	COG0697	spore germination
I6L49_RS06135	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6L49_RS06140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L49_RS06150	COG0307	riboflavin synthase, alpha
I6L49_RS06165	COG0534	Mate efflux family protein
I6L49_RS06195	COG3829	transcription factor binding
I6L49_RS06210	COG4681	YaeQ
I6L49_RS06225	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L49_RS06230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L49_RS06235	COG0586	Pfam SNARE associated Golgi protein
I6L49_RS06245	COG0556	nucleotide-excision repair
I6L49_RS06260	COG0569	domain protein
I6L49_RS06260	COG2985	domain, Protein
I6L49_RS06265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L49_RS06270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L49_RS06270	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6L49_RS06285	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L49_RS06300	COG1451	nucleotide metabolic process
I6L49_RS06315	COG0417	DNA replication proofreading
I6L49_RS06340	COG1560	Kdo2-lipid A biosynthetic process
I6L49_RS06345	COG1560	Kdo2-lipid A biosynthetic process
I6L49_RS06360	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6L49_RS06365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6L49_RS06370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6L49_RS06375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6L49_RS06380	COG2832	Protein of unknown function (DUF454)
I6L49_RS06385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L49_RS06400	COG1011	Hydrolase
I6L49_RS06405	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L49_RS06455	COG3593	DNA synthesis involved in DNA repair
I6L49_RS06470	COG0583	DNA-binding transcription factor activity
I6L49_RS06475	COG0730	response to heat
I6L49_RS06480	COG3148	PFAM DTW domain containing protein
I6L49_RS06485	COG1940	carbohydrate kinase activity
I6L49_RS06485	COG1846	Transcriptional regulator
I6L49_RS06490	COG0840	transmembrane signaling receptor activity
I6L49_RS06495	COG3012	SEC-C Motif Domain Protein
I6L49_RS06500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6L49_RS06505	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6L49_RS06510	COG0247	lactate metabolic process
I6L49_RS06525	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6L49_RS06530	COG0437	4 iron, 4 sulfur cluster binding
I6L49_RS06535	COG3301	Polysulphide reductase, NrfD
I6L49_RS06545	COG1138	Cytochrome C-type biogenesis protein
I6L49_RS06555	COG3088	subunit of a heme lyase
I6L49_RS06555	COG4235	cytochrome complex assembly
I6L49_RS06570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L49_RS06580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6L49_RS06590	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L49_RS06595	COG3842	ATPase activity
I6L49_RS06605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L49_RS06640	COG1115	amino acid carrier protein
I6L49_RS06645	COG1024	Enoyl-CoA hydratase
I6L49_RS06660	COG3162	membrane
I6L49_RS06665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L49_RS06670	COG0488	(ABC) transporter
I6L49_RS06675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L49_RS06680	COG0776	regulation of translation
I6L49_RS06685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6L49_RS06690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6L49_RS06695	COG0740	serine-type endopeptidase activity
I6L49_RS06700	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6L49_RS06710	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6L49_RS06715	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L49_RS06720	COG1136	(ABC) transporter
I6L49_RS06725	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L49_RS06735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L49_RS06740	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6L49_RS06745	COG4166	transmembrane transport
I6L49_RS06750	COG0697	spore germination
I6L49_RS06760	COG2062	phosphohistidine phosphatase, SixA
I6L49_RS06765	COG1025	Belongs to the peptidase M16 family
I6L49_RS06800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L49_RS06800	COG0519	Catalyzes the synthesis of GMP from XMP
I6L49_RS06805	COG0516	GMP reductase activity
I6L49_RS06805	COG0517	IMP dehydrogenase activity
I6L49_RS06810	COG3038	cytochrome b561
I6L49_RS06815	COG1570	exodeoxyribonuclease VII activity
I6L49_RS06820	COG2188	Transcriptional regulator
I6L49_RS06825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L49_RS06825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L49_RS06825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L49_RS06830	COG0383	alpha-mannosidase activity
I6L49_RS06835	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L49_RS06845	COG0386	Belongs to the glutathione peroxidase family
I6L49_RS06850	COG0513	Belongs to the DEAD box helicase family
I6L49_RS06865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L49_RS06870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L49_RS06875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6L49_RS06925	COG5001	Diguanylate cyclase
I6L49_RS06925	COG3300	MHYT domain
I6L49_RS06940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L49_RS06950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6L49_RS06955	COG0563	adenylate kinase activity
I6L49_RS06965	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6L49_RS06970	COG1286	toxin biosynthetic process
I6L49_RS06975	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6L49_RS06980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L49_RS06985	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L49_RS06990	COG0531	amino acid
I6L49_RS06990	COG1674	ftsk spoiiie
I6L49_RS07000	COG0686	Belongs to the AlaDH PNT family
I6L49_RS07005	COG0492	ferredoxin-NADP+ reductase activity
I6L49_RS07010	COG3706	GGDEF domain
I6L49_RS07015	COG3134	Outer membrane lipoprotein
I6L49_RS07020	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L49_RS07025	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6L49_RS07030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6L49_RS07035	COG0542	response to heat
I6L49_RS07040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L49_RS07045	COG1278	Cold shock
I6L49_RS07050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6L49_RS07070	COG0745	RESPONSE REGULATOR receiver
I6L49_RS07075	COG2205	protein histidine kinase activity
I6L49_RS07085	COG0392	lysyltransferase activity
I6L49_RS07085	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6L49_RS07100	COG0659	secondary active sulfate transmembrane transporter activity
I6L49_RS07135	COG0672	)-iron permease
I6L49_RS07160	COG2814	Major facilitator Superfamily
I6L49_RS07175	COG1136	(ABC) transporter
I6L49_RS07180	COG0577	efflux transmembrane transporter activity
I6L49_RS07195	COG0596	Alpha beta hydrolase
I6L49_RS07215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6L49_RS07220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L49_RS07220	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L49_RS07225	COG0527	aspartate kinase activity
I6L49_RS07235	COG1368	sulfuric ester hydrolase activity
I6L49_RS07240	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6L49_RS07245	COG4667	esterase of the alpha-beta hydrolase superfamily
I6L49_RS07265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L49_RS07265	COG1648	precorrin-2 dehydrogenase activity
I6L49_RS07275	COG0393	Putative heavy-metal-binding
I6L49_RS07280	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6L49_RS07285	COG0285	dihydrofolate synthase activity
I6L49_RS07290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6L49_RS07295	COG0101	tRNA pseudouridine synthase activity
I6L49_RS07305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L49_RS07310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L49_RS07315	COG0671	phosphoesterase, PA-phosphatase related
I6L49_RS07320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L49_RS07325	COG2056	Na+-H+ antiporter family
I6L49_RS07335	COG2050	protein possibly involved in aromatic compounds catabolism
I6L49_RS07345	COG0247	lactate metabolic process
I6L49_RS07345	COG0277	FAD linked oxidase domain protein
I6L49_RS07355	COG1253	flavin adenine dinucleotide binding
I6L49_RS07360	COG1902	pentaerythritol trinitrate reductase activity
I6L49_RS07375	COG0647	UMP catabolic process
I6L49_RS07380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L49_RS07380	COG4651	solute:proton antiporter activity
I6L49_RS07390	COG0367	asparagine synthase
I6L49_RS07405	COG4974	Belongs to the 'phage' integrase family
I6L49_RS07500	COG2755	lipolytic protein G-D-S-L family
I6L49_RS07500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6L49_RS07510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L49_RS07525	COG4695	Portal protein
I6L49_RS07610	COG3646	Phage regulatory protein
I6L49_RS07710	COG0322	excinuclease ABC activity
I6L49_RS07715	COG2197	response regulator
I6L49_RS07720	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6L49_RS07725	COG2835	tetraacyldisaccharide 4'-kinase activity
I6L49_RS07730	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L49_RS07735	COG1132	(ABC) transporter
I6L49_RS07740	COG0658	competence protein
I6L49_RS07740	COG2333	competence protein COMEC
I6L49_RS07755	COG1448	Aminotransferase
I6L49_RS07765	COG0583	DNA-binding transcription factor activity
I6L49_RS07770	COG3085	chromosome segregation
I6L49_RS07775	COG4574	serine-type endopeptidase inhibitor activity
I6L49_RS07780	COG0584	glycerophosphoryl diester phosphodiesterase
I6L49_RS07790	COG1349	DNA-binding transcription factor activity
I6L49_RS07795	COG2271	Major facilitator Superfamily
I6L49_RS07800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L49_RS07805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L49_RS07810	COG0840	transmembrane signaling receptor activity
I6L49_RS07820	COG0583	DNA-binding transcription factor activity
I6L49_RS07835	COG0656	L-ascorbic acid biosynthetic process
I6L49_RS07845	COG2814	Major facilitator Superfamily
I6L49_RS07850	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L49_RS07865	COG3220	belongs to the UPF0276 family
I6L49_RS07885	COG1294	oxidase, subunit
I6L49_RS07895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L49_RS07905	COG2979	Protein of unknown function (DUF533)
I6L49_RS07920	COG0583	DNA-binding transcription factor activity
I6L49_RS07930	COG1187	pseudouridine synthase activity
I6L49_RS07940	COG0346	lactoylglutathione lyase activity
I6L49_RS07960	COG4657	Part of a membrane complex involved in electron transport
I6L49_RS07965	COG2878	Part of a membrane complex involved in electron transport
I6L49_RS07975	COG4658	electron transport chain
I6L49_RS07980	COG4659	FMN binding
I6L49_RS07985	COG4660	Part of a membrane complex involved in electron transport
I6L49_RS07990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L49_RS07995	COG0346	lactoylglutathione lyase activity
I6L49_RS08020	COG2801	Transposase and inactivated derivatives
I6L49_RS08030	COG1199	ATP-dependent helicase activity
I6L49_RS08040	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6L49_RS08045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6L49_RS08050	COG1785	Belongs to the alkaline phosphatase family
I6L49_RS08070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L49_RS08075	COG2197	response regulator
I6L49_RS08085	COG2271	Major facilitator Superfamily
I6L49_RS08090	COG5001	Diguanylate cyclase
I6L49_RS08090	COG3300	MHYT domain
I6L49_RS08095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L49_RS08100	COG0765	amino acid transport
I6L49_RS08105	COG1126	abc transporter atp-binding protein
I6L49_RS08120	COG0531	amino acid
I6L49_RS08135	COG1253	flavin adenine dinucleotide binding
I6L49_RS08140	COG0704	Plays a role in the regulation of phosphate uptake
I6L49_RS08145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L49_RS08150	COG0581	inorganic phosphate transmembrane transporter activity
I6L49_RS08155	COG0573	inorganic phosphate transmembrane transporter activity
I6L49_RS08160	COG0590	tRNA wobble adenosine to inosine editing
I6L49_RS08175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L49_RS08195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6L49_RS08200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6L49_RS08205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L49_RS08210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L49_RS08235	COG2716	regulation of RNA biosynthetic process
I6L49_RS08240	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6L49_RS08250	COG2239	Acts as a magnesium transporter
I6L49_RS08255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L49_RS08270	COG1706	bacterial-type flagellum-dependent cell motility
I6L49_RS08275	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6L49_RS08285	COG4787	bacterial-type flagellum-dependent cell motility
I6L49_RS08305	COG1815	bacterial-type flagellum-dependent cell motility
I6L49_RS08310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6L49_RS08315	COG0784	Response regulator, receiver
I6L49_RS08315	COG0835	chemotaxis
I6L49_RS08320	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6L49_RS08335	COG0622	Phosphoesterase
I6L49_RS08340	COG4166	transmembrane transport
I6L49_RS08350	COG1187	pseudouridine synthase activity
I6L49_RS08355	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L49_RS08365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L49_RS08370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L49_RS08375	COG1882	Formate acetyltransferase
I6L49_RS08380	COG1349	DNA-binding transcription factor activity
I6L49_RS08410	COG1278	Cold shock
I6L49_RS08435	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6L49_RS08435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L49_RS08440	COG1028	Short-chain dehydrogenase reductase Sdr
I6L49_RS08445	COG3433	isochorismatase activity
I6L49_RS08445	COG1535	isochorismatase
I6L49_RS08450	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L49_RS08455	COG1169	isochorismate synthase
I6L49_RS08460	COG4771	TonB-dependent receptor
I6L49_RS08465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L49_RS08470	COG1609	Transcriptional regulator
I6L49_RS08475	COG0741	lytic transglycosylase activity
I6L49_RS08485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6L49_RS08505	COG2911	Protein conserved in bacteria
I6L49_RS08510	COG0729	surface antigen
I6L49_RS08520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L49_RS08530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L49_RS08540	COG4134	Bacterial extracellular solute-binding protein
I6L49_RS08550	COG4136	ATPase activity
I6L49_RS08555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L49_RS08560	COG2951	lytic endotransglycosylase activity
I6L49_RS08565	COG1846	Transcriptional regulator
I6L49_RS08575	COG0033	Phosphoglucomutase
I6L49_RS08580	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6L49_RS08585	COG0596	Alpha beta hydrolase
I6L49_RS08600	COG0716	FMN binding
I6L49_RS08610	COG0735	belongs to the Fur family
I6L49_RS08615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L49_RS08625	COG2190	(PTS) system
I6L49_RS08625	COG1263	PTS System
I6L49_RS08625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L49_RS08630	COG0363	glucosamine-6-phosphate deaminase activity
I6L49_RS08635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L49_RS08640	COG1846	Transcriptional regulator
I6L49_RS08640	COG1940	carbohydrate kinase activity
I6L49_RS08645	COG2194	sulfuric ester hydrolase activity
I6L49_RS08650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L49_RS08650	COG2199	diguanylate cyclase activity
I6L49_RS08655	COG3275	phosphorelay sensor kinase activity
I6L49_RS08660	COG3279	Response regulator of the LytR AlgR family
I6L49_RS08665	COG1966	Carbon starvation protein
I6L49_RS08675	COG1566	PFAM secretion protein HlyD family protein
I6L49_RS08680	COG1061	Type III restriction enzyme res subunit
I6L49_RS08685	COG2027	D-alanyl-D-alanine carboxypeptidase
I6L49_RS08690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L49_RS08695	COG3021	interspecies interaction between organisms
I6L49_RS08705	COG1607	acyl-coa hydrolase
I6L49_RS08710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L49_RS08720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L49_RS08720	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L49_RS08720	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L49_RS08720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L49_RS08735	COG0633	Ferredoxin
I6L49_RS08735	COG0633	Ferredoxin
I6L49_RS08735	COG3217	Mosc domain protein beta barrel domain protein
I6L49_RS08735	COG3217	Mosc domain protein beta barrel domain protein
I6L49_RS08745	COG0501	Belongs to the peptidase M48B family
I6L49_RS08750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6L49_RS08755	COG1073	alpha beta
I6L49_RS08755	COG2226	methyltransferase
I6L49_RS08760	COG0156	8-amino-7-oxononanoate synthase activity
I6L49_RS08765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L49_RS08770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L49_RS08785	COG0017	Asparaginyl-tRNA synthetase
I6L49_RS08795	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L49_RS08805	COG1473	amidohydrolase
I6L49_RS08810	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L49_RS08820	COG1393	Belongs to the ArsC family
I6L49_RS08825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L49_RS08830	COG1876	peptidase activity
I6L49_RS08840	COG3263	regulation of cellular component size
I6L49_RS08855	COG1280	lysine exporter protein (LysE YggA)
I6L49_RS08885	COG1957	nucleoside hydrolase
I6L49_RS08890	COG0564	pseudouridine synthase activity
I6L49_RS08900	COG1454	alcohol dehydrogenase
I6L49_RS08940	COG2894	cell division
I6L49_RS08950	COG4964	Belongs to the GSP D family
I6L49_RS08980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L49_RS08985	COG0702	epimerase
I6L49_RS08995	COG0095	Lipoate-protein ligase
I6L49_RS09005	COG1136	(ABC) transporter
I6L49_RS09005	COG0577	efflux transmembrane transporter activity
I6L49_RS09010	COG0577	efflux transmembrane transporter activity
I6L49_RS09010	COG1136	(ABC) transporter
I6L49_RS09015	COG1136	(ABC) transporter
I6L49_RS09015	COG0577	efflux transmembrane transporter activity
I6L49_RS09020	COG1566	PFAM secretion protein HlyD family protein
I6L49_RS09055	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L49_RS09065	COG1285	pathogenesis
I6L49_RS09095	COG0484	heat shock protein binding
I6L49_RS09100	COG0443	Heat shock 70 kDa protein
I6L49_RS09105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6L49_RS09110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L49_RS09115	COG0497	DNA recombination
I6L49_RS09120	COG1227	inorganic diphosphatase activity
I6L49_RS09125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L49_RS09130	COG0577	efflux transmembrane transporter activity
I6L49_RS09130	COG1136	(ABC) transporter
I6L49_RS09150	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L49_RS09170	COG0489	protein tyrosine kinase activity
I6L49_RS09170	COG3206	protein involved in exopolysaccharide biosynthesis
I6L49_RS09175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L49_RS09180	COG1596	polysaccharide export
I6L49_RS09190	COG1215	transferase activity, transferring glycosyl groups
I6L49_RS09205	COG1216	Glycosyl transferase, family 2
I6L49_RS09225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L49_RS09270	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6L49_RS09280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L49_RS09285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L49_RS09290	COG1309	transcriptional regulator
I6L49_RS09305	COG1342	Belongs to the UPF0251 family
I6L49_RS09325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L49_RS09345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L49_RS09350	COG0083	homoserine kinase activity
I6L49_RS09360	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6L49_RS09365	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6L49_RS09370	COG1946	Acyl-CoA thioesterase
I6L49_RS09380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L49_RS09390	COG0009	L-threonylcarbamoyladenylate synthase
I6L49_RS09400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L49_RS09405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L49_RS09405	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L49_RS09410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L49_RS09415	COG0135	phosphoribosylanthranilate isomerase activity
I6L49_RS09415	COG0134	indole-3-glycerol-phosphate synthase activity
I6L49_RS09420	COG0133	tryptophan synthase activity
I6L49_RS09425	COG0159	tryptophan synthase activity
I6L49_RS09450	COG1988	membrane-bound metal-dependent
I6L49_RS09470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L49_RS09480	COG0798	PFAM Bile acid sodium symporter
I6L49_RS09510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L49_RS09520	COG0745	RESPONSE REGULATOR receiver
I6L49_RS09535	COG4988	ABC transporter
I6L49_RS09540	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6L49_RS09560	COG1720	tRNA m6t6A37 methyltransferase activity
I6L49_RS09565	COG3038	cytochrome b561
I6L49_RS09605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L49_RS09610	COG1396	sequence-specific DNA binding
I6L49_RS09610	COG1917	Cupin 2, conserved barrel domain protein
I6L49_RS09625	COG0531	amino acid
I6L49_RS09635	COG0531	amino acid
I6L49_RS09645	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6L49_RS09650	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L49_RS09655	COG0405	Gamma-glutamyltransferase
I6L49_RS09660	COG2974	May be involved in recombination
I6L49_RS09670	COG0420	3'-5' exonuclease activity
I6L49_RS09675	COG0419	ATPase involved in DNA repair
I6L49_RS09680	COG3384	dioxygenase
I6L49_RS09690	COG0469	pyruvate kinase activity
I6L49_RS09695	COG3264	Mechanosensitive ion channel
I6L49_RS09695	COG1196	nuclear chromosome segregation
I6L49_RS09705	COG3590	peptidase
I6L49_RS09710	COG3706	GGDEF domain
I6L49_RS09715	COG2190	(PTS) system
I6L49_RS09725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L49_RS09730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L49_RS09735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L49_RS09750	COG2770	Histidine kinase
I6L49_RS09750	COG3437	response regulator, receiver
I6L49_RS09755	COG3267	Type II secretory pathway component ExeA
I6L49_RS09755	COG3409	Peptidoglycan-binding domain 1 protein
I6L49_RS09775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L49_RS09780	COG1459	type II secretion system
I6L49_RS09785	COG2165	general secretion pathway protein
I6L49_RS09800	COG2165	general secretion pathway protein
I6L49_RS09810	COG3156	type II secretion system protein K
I6L49_RS09820	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6L49_RS09830	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6L49_RS09855	COG0561	phosphatase activity
I6L49_RS09860	COG3623	hexulose-6-phosphate isomerase
I6L49_RS09870	COG0582	viral genome integration into host DNA
I6L49_RS09905	COG3210	domain, Protein
I6L49_RS09930	COG4983	Phage plasmid primase, P4 family domain protein
I6L49_RS09980	COG2003	Belongs to the UPF0758 family
I6L49_RS10035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6L49_RS10040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L49_RS10040	COG1263	PTS System
I6L49_RS10045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6L49_RS10050	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6L49_RS10065	COG0670	Belongs to the BI1 family
I6L49_RS10070	COG1289	transmembrane transporter activity
I6L49_RS10075	COG2920	part of a sulfur-relay system
I6L49_RS10080	COG0673	inositol 2-dehydrogenase activity
I6L49_RS10085	COG0583	DNA-binding transcription factor activity
I6L49_RS10110	COG1032	radical SAM domain protein
I6L49_RS10120	COG1566	PFAM secretion protein HlyD family protein
I6L49_RS10125	COG3706	GGDEF domain
I6L49_RS10130	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L49_RS10135	COG0531	amino acid
I6L49_RS10165	COG0281	malic enzyme
I6L49_RS10175	COG0534	Mate efflux family protein
I6L49_RS10190	COG2233	PERMEase
I6L49_RS10195	COG0095	Lipoate-protein ligase
I6L49_RS10200	COG1115	amino acid carrier protein
I6L49_RS10205	COG0019	diaminopimelate decarboxylase activity
I6L49_RS10215	COG0678	peroxiredoxin activity
I6L49_RS10240	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L49_RS10245	COG3142	Participates in the control of copper homeostasis
I6L49_RS10270	COG5002	protein histidine kinase activity
I6L49_RS10275	COG0745	RESPONSE REGULATOR receiver
I6L49_RS10280	COG0346	lactoylglutathione lyase activity
I6L49_RS10285	COG3284	Transcriptional regulator
I6L49_RS10300	COG0697	spore germination
I6L49_RS10310	COG3290	protein histidine kinase activity
I6L49_RS10315	COG0281	malic enzyme
I6L49_RS10325	COG1846	Transcriptional regulator
I6L49_RS10330	COG1566	PFAM secretion protein HlyD family protein
I6L49_RS10360	COG0602	queuosine metabolic process
I6L49_RS10365	COG1328	CTP reductase activity
I6L49_RS10375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6L49_RS10380	COG3115	cell septum assembly
I6L49_RS10385	COG1196	nuclear chromosome segregation
I6L49_RS10395	COG2860	membrane
I6L49_RS10405	COG3108	Peptidase M15
I6L49_RS10410	COG2989	Protein conserved in bacteria
I6L49_RS10425	COG0463	Glycosyl transferase, family 2
I6L49_RS10440	COG0366	Alpha amylase catalytic
I6L49_RS10475	COG2203	Gaf domain
I6L49_RS10475	COG2199	diguanylate cyclase activity
I6L49_RS10485	COG3590	peptidase
I6L49_RS10495	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L49_RS10500	COG1982	Orn Lys Arg decarboxylase major
I6L49_RS10505	COG0531	amino acid
I6L49_RS10510	COG3710	Transcriptional regulator
I6L49_RS10515	COG0531	amino acid
I6L49_RS10530	COG0814	amino acid
I6L49_RS10560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L49_RS10565	COG0739	heme binding
I6L49_RS10570	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L49_RS10580	COG0251	oxidation-reduction process
I6L49_RS10595	COG0583	DNA-binding transcription factor activity
I6L49_RS10600	COG3321	synthase
I6L49_RS10600	COG0604	alcohol dehydrogenase
I6L49_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
I6L49_RS10610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L49_RS10620	COG3091	SprT-like family
I6L49_RS10630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L49_RS10635	COG0189	ligase activity
I6L49_RS10640	COG1678	Uncharacterized ACR, COG1678
I6L49_RS10645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L49_RS10650	COG3104	oligopeptide transport
I6L49_RS10690	COG0714	Associated with various cellular activities
I6L49_RS10705	COG1115	amino acid carrier protein
I6L49_RS10710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L49_RS10720	COG0825	malonyl-CoA metabolic process
I6L49_RS10730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L49_RS10735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L49_RS10740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L49_RS10745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L49_RS10750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L49_RS10760	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L49_RS10765	COG0750	zinc metalloprotease
I6L49_RS10770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6L49_RS10775	COG0575	Belongs to the CDS family
I6L49_RS10780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L49_RS10785	COG0233	cytoplasmic translational termination
I6L49_RS10790	COG0528	UMP kinase activity
I6L49_RS10795	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6L49_RS10800	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L49_RS10805	COG0024	Methionine aminopeptidase
I6L49_RS10815	COG2171	N-acyltransferase activity
I6L49_RS10825	COG1263	PTS System
I6L49_RS10825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L49_RS10835	COG4580	involved in the transport of maltose and maltodextrins
I6L49_RS10845	COG0564	pseudouridine synthase activity
I6L49_RS10850	COG3098	single-species biofilm formation
I6L49_RS10875	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I6L49_RS10885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L49_RS10885	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L49_RS10900	COG1611	Belongs to the LOG family
I6L49_RS10905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L49_RS10910	COG0473	3-isopropylmalate dehydrogenase activity
I6L49_RS10920	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6L49_RS10925	COG2363	Small membrane protein
I6L49_RS10935	COG0583	DNA-binding transcription factor activity
I6L49_RS10940	COG0840	transmembrane signaling receptor activity
I6L49_RS10945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L49_RS10960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6L49_RS10965	COG1666	GTP binding
I6L49_RS10970	COG3248	Nucleoside-binding outer membrane protein
I6L49_RS10975	COG2211	Major facilitator Superfamily
I6L49_RS10980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L49_RS10990	COG2813	Specifically methylates the guanine in position
I6L49_RS10995	COG0271	Belongs to the BolA IbaG family
I6L49_RS11000	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L49_RS11005	COG1805	sodium ion transport
I6L49_RS11010	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L49_RS11015	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L49_RS11020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L49_RS11025	COG2871	sodium ion transport
I6L49_RS11030	COG1477	protein flavinylation
I6L49_RS11060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L49_RS11075	COG0300	oxidoreductase activity
I6L49_RS11085	COG0415	Belongs to the DNA photolyase family
I6L49_RS11090	COG0789	Transcriptional regulator
I6L49_RS11095	COG3272	Protein of unknown function (DUF1722)
I6L49_RS11125	COG0077	Prephenate dehydratase
I6L49_RS11125	COG1605	Chorismate mutase
I6L49_RS11165	COG0300	oxidoreductase activity
I6L49_RS11190	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6L49_RS11230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L49_RS11235	COG0826	peptidase U32
I6L49_RS11240	COG1280	lysine exporter protein (LysE YggA)
I6L49_RS11250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L49_RS11260	COG0745	RESPONSE REGULATOR receiver
I6L49_RS11270	COG0643	Histidine kinase
I6L49_RS11270	COG2198	Histidine kinase
I6L49_RS11280	COG0835	chemotaxis
I6L49_RS11285	COG0840	transmembrane signaling receptor activity
I6L49_RS11295	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6L49_RS11300	COG2201	protein-glutamate methylesterase activity
I6L49_RS11305	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L49_RS11315	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6L49_RS11320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L49_RS11325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L49_RS11330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6L49_RS11335	COG0195	Participates in both transcription termination and antitermination
I6L49_RS11340	COG0779	Required for maturation of 30S ribosomal subunits
I6L49_RS11355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6L49_RS11360	COG0149	triose-phosphate isomerase activity
I6L49_RS11365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L49_RS11370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L49_RS11380	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6L49_RS11385	COG1534	Rna-binding protein
I6L49_RS11400	COG1360	Flagellar Motor Protein
I6L49_RS11405	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L49_RS11410	COG1722	exodeoxyribonuclease VII activity
I6L49_RS11415	COG0142	geranyltranstransferase activity
I6L49_RS11420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6L49_RS11425	COG0737	Belongs to the 5'-nucleotidase family
I6L49_RS11445	COG2204	response regulator
I6L49_RS11450	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L49_RS11460	COG2900	Belongs to the SlyX family
I6L49_RS11470	COG0601	transmembrane transport
I6L49_RS11485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L49_RS11490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L49_RS11495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L49_RS11500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6L49_RS11515	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L49_RS11515	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L49_RS11520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6L49_RS11525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6L49_RS11535	COG0784	Response regulator, receiver
I6L49_RS11535	COG2198	Histidine kinase
I6L49_RS11535	COG2205	protein histidine kinase activity
I6L49_RS11540	COG1879	ABC-type sugar transport system periplasmic component
I6L49_RS11550	COG0745	RESPONSE REGULATOR receiver
I6L49_RS11555	COG3005	denitrification pathway
I6L49_RS11565	COG3381	protein complex oligomerization
I6L49_RS11585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L49_RS11590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6L49_RS11595	COG0511	ligase activity, forming carbon-carbon bonds
I6L49_RS11600	COG0439	Biotin carboxylase
I6L49_RS11610	COG4145	pantothenate transmembrane transporter activity
I6L49_RS11615	COG2190	(PTS) system
I6L49_RS11615	COG1263	PTS System
I6L49_RS11615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L49_RS11620	COG0583	DNA-binding transcription factor activity
I6L49_RS11625	COG0604	alcohol dehydrogenase
I6L49_RS11630	COG2264	protein methyltransferase activity
I6L49_RS11640	COG0778	Nitroreductase
I6L49_RS11645	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L49_RS11645	COG1902	pentaerythritol trinitrate reductase activity
I6L49_RS11650	COG0616	signal peptide processing
I6L49_RS11670	COG0848	biopolymer transport protein
I6L49_RS11675	COG0811	peptide transport
I6L49_RS11680	COG0811	peptide transport
I6L49_RS11695	COG4174	ABC transporter (Permease)
I6L49_RS11700	COG4239	(ABC) transporter, permease
I6L49_RS11710	COG0444	Belongs to the ABC transporter superfamily
I6L49_RS11715	COG4608	Belongs to the ABC transporter superfamily
I6L49_RS11730	COG3416	Protein conserved in bacteria
I6L49_RS11740	COG0741	lytic transglycosylase activity
I6L49_RS11755	COG0488	(ABC) transporter
I6L49_RS11765	COG2252	PERMEase
I6L49_RS11770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L49_RS11775	COG0840	transmembrane signaling receptor activity
I6L49_RS11785	COG1278	Cold shock
I6L49_RS11825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L49_RS11835	COG0688	phosphatidylethanolamine metabolic process
I6L49_RS11840	COG4628	conserved protein (DUF2132)
I6L49_RS11855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6L49_RS11870	COG1073	alpha beta
I6L49_RS11875	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6L49_RS11880	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L49_RS11885	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L49_RS11890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L49_RS11895	COG3178	'Phosphotransferase
I6L49_RS11900	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6L49_RS11905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L49_RS11910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L49_RS11915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L49_RS11920	COG2967	ApaG domain
I6L49_RS11925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L49_RS11940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L49_RS11955	COG3314	Sporulation integral membrane protein YlbJ
I6L49_RS11960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6L49_RS11965	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6L49_RS11970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6L49_RS11975	COG0142	geranyltranstransferase activity
I6L49_RS11980	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6L49_RS11985	COG0330	HflC and HflK could
I6L49_RS11990	COG0330	HflC and HflK could
I6L49_RS11995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L49_RS12000	COG1923	regulation of RNA biosynthetic process
I6L49_RS12005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6L49_RS12010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L49_RS12015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L49_RS12025	COG0802	atpase or kinase
I6L49_RS12030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L49_RS12030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L49_RS12050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L49_RS12055	COG2011	ABC-type metal ion transport system permease component
I6L49_RS12060	COG1464	Belongs to the NlpA lipoprotein family
I6L49_RS12095	COG0784	Response regulator, receiver
I6L49_RS12095	COG5002	protein histidine kinase activity
I6L49_RS12095	COG2198	Histidine kinase
I6L49_RS12130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6L49_RS12135	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6L49_RS12140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L49_RS12145	COG2716	regulation of RNA biosynthetic process
I6L49_RS12150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L49_RS12155	COG3013	Belongs to the UPF0304 family
I6L49_RS12165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L49_RS12170	COG0280	phosphate acetyltransferase
I6L49_RS12170	COG0857	belongs to the CobB CobQ family
I6L49_RS12175	COG1555	photosystem II stabilization
I6L49_RS12180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L49_RS12185	COG3104	oligopeptide transport
I6L49_RS12190	COG0745	RESPONSE REGULATOR receiver
I6L49_RS12220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L49_RS12235	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L49_RS12270	COG0440	acetolactate synthase activity
I6L49_RS12275	COG0028	Belongs to the TPP enzyme family
I6L49_RS12300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L49_RS12305	COG0473	3-isopropylmalate dehydrogenase activity
I6L49_RS12310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6L49_RS12315	COG0066	3-isopropylmalate dehydratase activity
I6L49_RS12330	COG4143	(ABC) transporter
I6L49_RS12335	COG1178	ABC-type Fe3 transport system permease component
I6L49_RS12340	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6L49_RS12345	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6L49_RS12395	COG0459	protein refolding
I6L49_RS12400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6L49_RS12405	COG0534	Mate efflux family protein
I6L49_RS12410	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6L49_RS12415	COG1027	Aspartate ammonia-lyase
I6L49_RS12420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L49_RS12425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6L49_RS12430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6L49_RS12435	COG1610	YqeY-like protein
I6L49_RS12440	COG0358	DNA primase activity
I6L49_RS12445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L49_RS12465	COG0151	Belongs to the GarS family
I6L49_RS12470	COG0138	bifunctional purine biosynthesis protein purh
I6L49_RS12480	COG3036	rescue of stalled ribosome
I6L49_RS12485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L49_RS12490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L49_RS12500	COG0673	inositol 2-dehydrogenase activity
I6L49_RS12510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L49_RS12515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L49_RS12525	COG0583	DNA-binding transcription factor activity
I6L49_RS12530	COG0477	Major facilitator Superfamily
I6L49_RS12550	COG1028	Short-chain dehydrogenase reductase Sdr
I6L49_RS12560	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6L49_RS12575	COG0456	acetyltransferase
I6L49_RS12585	COG1022	Amp-dependent synthetase and ligase
I6L49_RS12595	COG2918	glutathione biosynthetic process
I6L49_RS12600	COG0612	Peptidase, M16
I6L49_RS12605	COG1238	metal cluster binding
I6L49_RS12610	COG1064	alcohol dehydrogenase
I6L49_RS12635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L49_RS12640	COG0359	binds to the 23S rRNA
I6L49_RS12645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6L49_RS12650	COG0360	Binds together with S18 to 16S ribosomal RNA
I6L49_RS12655	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L49_RS12670	COG0776	regulation of translation
I6L49_RS12685	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6L49_RS12700	COG0560	Phosphoserine phosphatase
I6L49_RS12710	COG0813	purine-nucleoside phosphorylase activity
I6L49_RS12715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6L49_RS12720	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6L49_RS12725	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6L49_RS12735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L49_RS12740	COG0084	hydrolase, TatD family'
I6L49_RS12745	COG2165	general secretion pathway protein
I6L49_RS12755	COG1854	S-ribosylhomocysteine lyase activity
I6L49_RS12770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L49_RS12770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L49_RS12820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6L49_RS12825	COG1047	Peptidyl-prolyl cis-trans
I6L49_RS12830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6L49_RS12835	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L49_RS12840	COG0196	riboflavin kinase activity
I6L49_RS12845	COG0728	peptidoglycan biosynthetic process
I6L49_RS12850	COG0268	Binds directly to 16S ribosomal RNA
I6L49_RS12855	COG0640	Transcriptional regulator
I6L49_RS12860	COG0583	DNA-binding transcription factor activity
I6L49_RS12870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L49_RS12875	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6L49_RS12880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6L49_RS12890	COG1051	belongs to the nudix hydrolase family
I6L49_RS12895	COG3066	DNA modification
I6L49_RS12905	COG0335	large ribosomal subunit rRNA binding
I6L49_RS12910	COG0336	Belongs to the RNA methyltransferase TrmD family
I6L49_RS12915	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L49_RS12920	COG0228	four-way junction DNA binding
I6L49_RS12925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L49_RS12930	COG4137	Cytochrome C assembly protein
I6L49_RS12935	COG4536	flavin adenine dinucleotide binding
I6L49_RS12945	COG1017	nitric oxide dioxygenase activity
I6L49_RS12945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L49_RS12950	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6L49_RS12955	COG0039	L-malate dehydrogenase activity
I6L49_RS12960	COG4160	amino acid transport
I6L49_RS12965	COG4215	(ABC) transporter
I6L49_RS12970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L49_RS12975	COG1126	abc transporter atp-binding protein
I6L49_RS12980	COG1438	arginine binding
I6L49_RS12985	COG2837	iron assimilation
I6L49_RS12990	COG3842	ATPase activity
I6L49_RS13000	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L49_RS13005	COG0347	Belongs to the P(II) protein family
I6L49_RS13030	COG3022	response to hydroperoxide
I6L49_RS13045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L49_RS13050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6L49_RS13055	COG0762	integral membrane protein
I6L49_RS13060	COG1872	DUF167
I6L49_RS13070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L49_RS13075	COG0583	DNA-binding transcription factor activity
I6L49_RS13090	COG1929	Belongs to the glycerate kinase type-1 family
I6L49_RS13095	COG2610	gluconate transmembrane transporter activity
I6L49_RS13100	COG3835	regulator
I6L49_RS13105	COG3112	Uncharacterised protein family (UPF0231)
I6L49_RS13125	COG3568	Endonuclease Exonuclease Phosphatase
I6L49_RS13135	COG0513	Belongs to the DEAD box helicase family
I6L49_RS13175	COG1448	Aminotransferase
I6L49_RS13190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L49_RS13195	COG1328	CTP reductase activity
I6L49_RS13220	COG0543	2 iron, 2 sulfur cluster binding
I6L49_RS13220	COG0633	Ferredoxin
I6L49_RS13235	COG1215	transferase activity, transferring glycosyl groups
I6L49_RS13240	COG0726	polysaccharide deacetylase
I6L49_RS13240	COG1649	PFAM Uncharacterised BCR, COG1649
I6L49_RS13255	COG0840	transmembrane signaling receptor activity
I6L49_RS13260	COG3397	chitin binding
I6L49_RS13265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L49_RS13270	COG1126	abc transporter atp-binding protein
I6L49_RS13280	COG0765	amino acid transport
I6L49_RS13285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L49_RS13290	COG0583	DNA-binding transcription factor activity
I6L49_RS13295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L49_RS13300	COG4208	sulfate ABC transporter
I6L49_RS13305	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L49_RS13315	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L49_RS13320	COG3174	membrane
I6L49_RS13325	COG0110	maltose O-acetyltransferase activity
I6L49_RS13340	COG1011	Hydrolase
I6L49_RS13345	COG0494	nUDIX hydrolase
I6L49_RS13350	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6L49_RS13355	COG0814	amino acid
I6L49_RS13360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L49_RS13375	COG0626	cystathionine gamma-synthase activity
I6L49_RS13380	COG0460	homoserine dehydrogenase
I6L49_RS13380	COG0527	aspartate kinase activity
I6L49_RS13385	COG0306	phosphate transporter
I6L49_RS13390	COG1392	Phosphate transport regulator
I6L49_RS13400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L49_RS13405	COG2813	Specifically methylates the guanine in position
I6L49_RS13410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6L49_RS13415	COG0297	glycogen (starch) synthase activity
I6L49_RS13455	COG1757	Na H antiporter
I6L49_RS13460	COG0316	Belongs to the HesB IscA family
I6L49_RS13470	COG0038	chloride channel
I6L49_RS13475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6L49_RS13490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L49_RS13490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L49_RS13525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L49_RS13530	COG0564	pseudouridine synthase activity
I6L49_RS13540	COG0110	maltose O-acetyltransferase activity
I6L49_RS13545	COG0366	Alpha amylase catalytic
I6L49_RS13550	COG1263	PTS System
I6L49_RS13550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L49_RS13570	COG0252	asparaginase activity
I6L49_RS13575	COG1253	flavin adenine dinucleotide binding
I6L49_RS13580	COG0586	Pfam SNARE associated Golgi protein
I6L49_RS13585	COG1686	Belongs to the peptidase S11 family
I6L49_RS13620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6L49_RS13625	COG0527	aspartate kinase activity
I6L49_RS13630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L49_RS13640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6L49_RS13645	COG1546	Belongs to the CinA family
I6L49_RS13650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6L49_RS13655	COG4667	esterase of the alpha-beta hydrolase superfamily
I6L49_RS13665	COG1346	cytolysis
I6L49_RS13670	COG1380	Effector of murein hydrolase LrgA
I6L49_RS13675	COG0583	DNA-binding transcription factor activity
I6L49_RS13685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L49_RS13705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L49_RS13710	COG2022	thiamine diphosphate biosynthetic process
I6L49_RS13720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L49_RS13725	COG0352	thiamine-phosphate diphosphorylase activity
I6L49_RS13730	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6L49_RS13750	COG0745	RESPONSE REGULATOR receiver
I6L49_RS13760	COG0189	ligase activity
I6L49_RS13810	COG0477	Major facilitator Superfamily
I6L49_RS13825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6L49_RS13830	COG1263	PTS System
I6L49_RS13830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L49_RS13835	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6L49_RS13840	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6L49_RS13850	COG0312	modulator of DNA gyrase
I6L49_RS13855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L49_RS13865	COG3164	Protein of unknown function
I6L49_RS13870	COG1530	ribonuclease E activity
I6L49_RS13875	COG0424	maF-like protein
I6L49_RS13880	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L49_RS13885	COG1792	Involved in formation and maintenance of cell shape
I6L49_RS13890	COG1077	Cell shape determining protein MreB Mrl
I6L49_RS13915	COG4968	Prepilin-type N-terminal cleavage methylation domain
I6L49_RS13920	COG2165	general secretion pathway protein
I6L49_RS13925	COG2165	general secretion pathway protein
I6L49_RS13935	COG1459	type II secretion system
I6L49_RS13940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L49_RS13985	COG2199	diguanylate cyclase activity
I6L49_RS13985	COG2200	EAL domain
I6L49_RS13990	COG2200	EAL domain
I6L49_RS13995	COG0387	Pfam Sodium calcium exchanger
I6L49_RS14000	COG2986	histidine ammonia-lyase
I6L49_RS14005	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6L49_RS14010	COG0010	Belongs to the arginase family
I6L49_RS14015	COG1228	amidohydrolase
I6L49_RS14020	COG2188	Transcriptional regulator
I6L49_RS14025	COG0288	reversible hydration of carbon dioxide
I6L49_RS14035	COG2177	Part of the ABC transporter FtsEX involved in
I6L49_RS14040	COG2884	Cell division ATP-binding protein ftsE
I6L49_RS14045	COG0552	protein localization to endoplasmic reticulum
I6L49_RS14050	COG0742	ribosomal rna small subunit methyltransferase
I6L49_RS14075	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L49_RS14080	COG0583	DNA-binding transcription factor activity
I6L49_RS14085	COG4221	oxidoreductase activity
I6L49_RS14100	COG1770	oligopeptidase
I6L49_RS14115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L49_RS14125	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L49_RS14135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L49_RS14145	COG2095	MarC family integral membrane protein
I6L49_RS14155	COG1301	dicarboxylic acid transport
I6L49_RS14180	COG3714	YhhN family
I6L49_RS14230	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L49_RS14235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L49_RS14240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L49_RS14245	COG0049	tRNA binding
I6L49_RS14250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L49_RS14255	COG2168	tRNA wobble position uridine thiolation
I6L49_RS14260	COG2923	Belongs to the DsrF TusC family
I6L49_RS14265	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L49_RS14275	COG2964	Protein conserved in bacteria
I6L49_RS14280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6L49_RS14285	COG0085	RNA polymerase activity
I6L49_RS14290	COG0222	ribosome binding
I6L49_RS14295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6L49_RS14300	COG0081	regulation of translation
I6L49_RS14305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6L49_RS14310	COG0250	Participates in transcription elongation, termination and antitermination
I6L49_RS14325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L49_RS14350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6L49_RS14355	COG0569	domain protein
I6L49_RS14360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L49_RS14390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L49_RS14390	COG4191	Histidine kinase
I6L49_RS14395	COG3005	denitrification pathway
I6L49_RS14400	COG0243	molybdopterin cofactor binding
I6L49_RS14445	COG2204	response regulator
I6L49_RS14455	COG2205	protein histidine kinase activity
I6L49_RS14470	COG1028	Short-chain dehydrogenase reductase Sdr
I6L49_RS14475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L49_RS14475	COG0617	tRNA 3'-terminal CCA addition
I6L49_RS14475	COG0517	IMP dehydrogenase activity
I6L49_RS14480	COG5413	integral membrane protein
I6L49_RS14490	COG1522	sequence-specific DNA binding
I6L49_RS14495	COG2502	aspartate--ammonia ligase
I6L49_RS14500	COG0542	response to heat
I6L49_RS14510	COG0564	pseudouridine synthase activity
I6L49_RS14515	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L49_RS14520	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L49_RS14530	COG3681	Belongs to the UPF0597 family
I6L49_RS14535	COG2964	Protein conserved in bacteria
I6L49_RS14545	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6L49_RS14550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6L49_RS14555	COG1979	alcohol dehydrogenase
I6L49_RS14560	COG2207	Transcriptional regulator
I6L49_RS14565	COG3040	lipid binding
I6L49_RS14580	COG0583	DNA-binding transcription factor activity
I6L49_RS14600	COG0540	Belongs to the ATCase OTCase family
I6L49_RS14605	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6L49_RS14610	COG1438	arginine binding
I6L49_RS14615	COG1288	antiporter activity
I6L49_RS14620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L49_RS14650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L49_RS14660	COG3078	GTPase activator activity
I6L49_RS14670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6L49_RS14680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6L49_RS14685	COG0408	coproporphyrinogen oxidase activity
I6L49_RS14690	COG0009	L-threonylcarbamoyladenylate synthase
I6L49_RS14700	COG0551	DNA topoisomerase type I activity
I6L49_RS14705	COG2922	Belongs to the Smg family
I6L49_RS14710	COG0758	DNA mediated transformation
I6L49_RS14715	COG1652	LysM domain
I6L49_RS14720	COG0242	peptide deformylase activity
I6L49_RS14725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6L49_RS14730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L49_RS14730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L49_RS14735	COG0569	domain protein
I6L49_RS14740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L49_RS14745	COG1217	gtp-binding protein TYPA
I6L49_RS14750	COG0174	glutamine synthetase
I6L49_RS14765	COG2204	response regulator
I6L49_RS14770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L49_RS14780	COG1322	Protein conserved in bacteria
I6L49_RS14800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L49_RS14805	COG0583	DNA-binding transcription factor activity
I6L49_RS14810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L49_RS14810	COG0519	Catalyzes the synthesis of GMP from XMP
I6L49_RS14820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L49_RS14825	COG1396	sequence-specific DNA binding
I6L49_RS14830	COG1012	belongs to the aldehyde dehydrogenase family
I6L49_RS14840	COG2962	Rard protein
I6L49_RS14845	COG0840	transmembrane signaling receptor activity
I6L49_RS14850	COG2391	methyltransferase activity
I6L49_RS14865	COG0129	dihydroxy-acid dehydratase activity
I6L49_RS14875	COG3978	acetolactate synthase activity
I6L49_RS14885	COG0606	chelatase, subunit chli
I6L49_RS14890	COG0204	Acyl-transferase
I6L49_RS14895	COG0204	Acyl-transferase
I6L49_RS14900	COG1683	Conserved Protein
I6L49_RS14910	COG1335	isochorismatase
I6L49_RS14920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L49_RS14925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L49_RS14935	COG3084	Protein conserved in bacteria
I6L49_RS14940	COG3706	GGDEF domain
I6L49_RS14940	COG4251	negative regulation of phosphorylation
I6L49_RS14940	COG5001	Diguanylate cyclase
I6L49_RS14940	COG2203	Gaf domain
I6L49_RS14955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6L49_RS14960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6L49_RS14965	COG1561	YicC-like family, N-terminal region
I6L49_RS14970	COG0583	DNA-binding transcription factor activity
I6L49_RS14990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L49_RS14995	COG0385	Bile acid
I6L49_RS15000	COG0531	amino acid
I6L49_RS15005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L49_RS15010	COG0531	amino acid
I6L49_RS15015	COG2731	YhcH YjgK YiaL family protein
I6L49_RS15020	COG3250	beta-galactosidase activity
I6L49_RS15025	COG1609	Transcriptional regulator
I6L49_RS15060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L49_RS15065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L49_RS15065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L49_RS15070	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6L49_RS15075	COG3074	FtsZ-dependent cytokinesis
I6L49_RS15085	COG1045	serine acetyltransferase
I6L49_RS15095	COG0745	RESPONSE REGULATOR receiver
I6L49_RS15100	COG2205	protein histidine kinase activity
I6L49_RS15105	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L49_RS15110	COG0534	Mate efflux family protein
I6L49_RS15125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L49_RS15130	COG2937	Belongs to the GPAT DAPAT family
I6L49_RS15135	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L49_RS15140	COG3161	chorismate lyase activity
I6L49_RS15160	COG0604	alcohol dehydrogenase
I6L49_RS15165	COG1519	Transferase
I6L49_RS15170	COG0859	PFAM glycosyl transferase family 9
I6L49_RS15175	COG0463	Glycosyl transferase, family 2
I6L49_RS15180	COG0859	PFAM glycosyl transferase family 9
I6L49_RS15185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6L49_RS15190	COG2990	Protein conserved in bacteria
I6L49_RS15195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6L49_RS15205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6L49_RS15210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6L49_RS15215	COG2003	Belongs to the UPF0758 family
I6L49_RS15220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L49_RS15225	COG0756	dUTP diphosphatase activity
I6L49_RS15230	COG1309	transcriptional regulator
I6L49_RS15235	COG0668	transmembrane transport
I6L49_RS15240	COG0166	Belongs to the GPI family
I6L49_RS15245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L49_RS15265	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L49_RS15265	COG1042	CoA-binding domain protein
I6L49_RS15265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L49_RS15295	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6L49_RS15300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L49_RS15305	COG1739	Uncharacterized protein family UPF0029
I6L49_RS15310	COG0006	proline dipeptidase activity
I6L49_RS15315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L49_RS15320	COG1024	Enoyl-CoA hydratase
I6L49_RS15320	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L49_RS15325	COG0183	Belongs to the thiolase family
I6L49_RS15350	COG0425	Belongs to the sulfur carrier protein TusA family
I6L49_RS15355	COG0251	oxidation-reduction process
I6L49_RS15360	COG2885	chlorophyll binding
I6L49_RS15365	COG2818	Glycosylase
I6L49_RS15370	COG0752	glycyl-tRNA synthetase alpha subunit
I6L49_RS15375	COG0751	glycine-tRNA ligase activity
I6L49_RS15400	COG2188	Transcriptional regulator
I6L49_RS15415	COG1609	Transcriptional regulator
I6L49_RS15445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L49_RS15460	COG2960	long-chain fatty acid transporting porin activity
I6L49_RS15465	COG5001	Diguanylate cyclase
I6L49_RS15475	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6L49_RS15490	COG3118	belongs to the thioredoxin family
I6L49_RS15495	COG0513	Belongs to the DEAD box helicase family
I6L49_RS15500	COG0248	Ppx GppA phosphatase
I6L49_RS15510	COG0742	ribosomal rna small subunit methyltransferase
I6L49_RS15530	COG3469	chitinase activity
I6L49_RS15535	COG3397	chitin binding
I6L49_RS15545	COG0084	hydrolase, TatD family'
I6L49_RS15550	COG0805	protein transport
I6L49_RS15555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L49_RS15560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L49_RS15565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L49_RS15570	COG3165	ubiquinone biosynthetic process from chorismate
I6L49_RS15575	COG2226	methyltransferase
I6L49_RS15580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6L49_RS15585	COG0402	S-adenosylhomocysteine deaminase activity
I6L49_RS15590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L49_RS15625	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6L49_RS15630	COG0848	biopolymer transport protein
I6L49_RS15635	COG0811	peptide transport
I6L49_RS15640	COG0811	peptide transport
I6L49_RS15650	COG2771	luxR family
I6L49_RS15655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L49_RS15660	COG1349	DNA-binding transcription factor activity
I6L49_RS15665	COG0745	RESPONSE REGULATOR receiver
I6L49_RS15670	COG2205	protein histidine kinase activity
I6L49_RS15685	COG4452	Inner membrane protein CreD
I6L49_RS15700	COG0297	glycogen (starch) synthase activity
I6L49_RS15700	COG0438	transferase activity, transferring glycosyl groups
I6L49_RS15745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L49_RS15750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L49_RS15755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6L49_RS15760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L49_RS15765	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6L49_RS15770	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L49_RS15775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6L49_RS15780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6L49_RS15790	COG0356	it plays a direct role in the translocation of protons across the membrane
I6L49_RS15800	COG1475	DNA binding
I6L49_RS15805	COG1192	Involved in chromosome partitioning
I6L49_RS15810	COG0357	Ribosomal RNA small subunit methyltransferase G
I6L49_RS15815	COG0445	tRNA wobble uridine modification
I6L49_RS15820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L49_RS15830	COG4615	Cyclic peptide transporter
I6L49_RS15835	COG1120	ATPase activity
I6L49_RS15840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L49_RS15850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6L49_RS15855	COG0706	membrane insertase activity
I6L49_RS15860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6L49_RS15865	COG0594	ribonuclease P activity
I6L49_RS15870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6L49_RS15875	COG1126	abc transporter atp-binding protein
I6L49_RS15890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L49_RS15895	COG0592	DNA-directed DNA polymerase activity
I6L49_RS15905	COG0187	DNA topoisomerase II activity
I6L49_RS15925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6L49_RS15930	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L49_RS15935	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L49_RS15940	COG3977	Valine--pyruvate aminotransferase
I6L49_RS15955	COG2814	Major facilitator Superfamily
I6L49_RS15960	COG0745	RESPONSE REGULATOR receiver
I6L49_RS15965	COG2205	protein histidine kinase activity
I6L49_RS15985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L49_RS15990	COG4191	Histidine kinase
I6L49_RS15990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L49_RS15995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L49_RS16000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L49_RS16005	COG1309	transcriptional regulator
I6L49_RS16035	COG0561	phosphatase activity
I6L49_RS16040	COG2267	carboxylic ester hydrolase activity
I6L49_RS16050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L49_RS16055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L49_RS16060	COG1758	RNA polymerase activity
I6L49_RS16065	COG0194	GDP metabolic process
I6L49_RS16070	COG0859	PFAM glycosyl transferase family 9
I6L49_RS16075	COG3642	lipopolysaccharide core region biosynthetic process
I6L49_RS16115	COG0589	response to stress
I6L49_RS16120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L49_RS16125	COG1528	Iron-storage protein
I6L49_RS16130	COG2081	HI0933 family
I6L49_RS16135	COG3275	phosphorelay sensor kinase activity
I6L49_RS16140	COG3279	Response regulator of the LytR AlgR family
I6L49_RS16145	COG2223	nitrite transmembrane transporter activity
I6L49_RS16150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L49_RS16155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6L49_RS16170	COG0583	DNA-binding transcription factor activity
I6L49_RS16215	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L49_RS16220	COG2166	iron-sulfur cluster assembly
I6L49_RS16225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L49_RS16240	COG3245	cytochrome
I6L49_RS16245	COG1063	alcohol dehydrogenase
I6L49_RS16260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L49_RS16305	COG1280	lysine exporter protein (LysE YggA)
I6L49_RS16345	COG1943	Transposase
I6L49_RS16355	COG0210	DNA helicase
I6L49_RS16360	COG1744	ABC transporter substrate-binding protein PnrA-like
I6L49_RS16365	COG3845	ABC transporter
I6L49_RS16370	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6L49_RS16375	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6L49_RS16380	COG0737	Belongs to the 5'-nucleotidase family
I6L49_RS16390	COG2239	Acts as a magnesium transporter
I6L49_RS16395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L49_RS16395	COG1648	precorrin-2 dehydrogenase activity
I6L49_RS16400	COG2116	formate transmembrane transporter activity
I6L49_RS16410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L49_RS16415	COG0842	Transport permease protein
I6L49_RS16420	COG0842	Transport permease protein
I6L49_RS16425	COG1131	(ABC) transporter
I6L49_RS16430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L49_RS16440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6L49_RS16445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6L49_RS16455	COG0018	arginyl-trna synthetase
I6L49_RS16465	COG1595	DNA-templated transcription, initiation
I6L49_RS16475	COG1968	undecaprenyl-diphosphatase activity
I6L49_RS16490	COG2211	Major facilitator Superfamily
I6L49_RS16500	COG1609	Transcriptional regulator
I6L49_RS16505	COG2017	converts alpha-aldose to the beta-anomer
I6L49_RS16510	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6L49_RS16515	COG1085	galactose-1-phosphate uridylyltransferase
I6L49_RS16520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L49_RS16525	COG1609	Transcriptional regulator
I6L49_RS16530	COG3250	beta-galactosidase activity
I6L49_RS16540	COG1129	ABC transporter
I6L49_RS16545	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6L49_RS16555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L49_RS16570	COG0366	Alpha amylase catalytic
I6L49_RS16585	COG0443	Heat shock 70 kDa protein
I6L49_RS16590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L49_RS16595	COG3045	CreA protein
I6L49_RS16615	COG0174	glutamine synthetase
I6L49_RS16635	COG3842	ATPase activity
I6L49_RS16640	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L49_RS16645	COG1177	transmembrane transport
I6L49_RS16650	COG2258	MOSC domain
I6L49_RS16665	COG2050	protein possibly involved in aromatic compounds catabolism
I6L49_RS16670	COG0514	ATP-dependent DNA helicase (RecQ)
I6L49_RS16680	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L49_RS16690	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6L49_RS16695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L49_RS16710	COG0254	rRNA binding
I6L49_RS16715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L49_RS16725	COG0702	epimerase
I6L49_RS16735	COG0814	amino acid
I6L49_RS16740	COG0281	malic enzyme
I6L49_RS16745	COG1295	ribonuclease BN
I6L49_RS16750	COG1490	D-aminoacyl-tRNA deacylase activity
I6L49_RS16760	COG0456	acetyltransferase
I6L49_RS16770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L49_RS16775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L49_RS16780	COG2610	gluconate transmembrane transporter activity
I6L49_RS16785	COG3265	gluconokinase activity
I6L49_RS16790	COG0129	dihydroxy-acid dehydratase activity
I6L49_RS16795	COG0800	Aldolase
I6L49_RS16810	COG1609	Transcriptional regulator
I6L49_RS16820	COG4942	peptidase
I6L49_RS16825	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L49_RS16830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L49_RS16835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6L49_RS16840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6L49_RS16845	COG0316	Belongs to the HesB IscA family
I6L49_RS16845	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6L49_RS16850	COG1040	competence protein
I6L49_RS16855	COG0596	Alpha beta hydrolase
I6L49_RS16875	COG2183	response to ionizing radiation
I6L49_RS16880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L49_RS16900	COG0051	transcription antitermination factor activity, RNA binding
I6L49_RS16905	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L49_RS16910	COG0088	Forms part of the polypeptide exit tunnel
I6L49_RS16915	COG0089	rRNA binding
I6L49_RS16920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6L49_RS16925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6L49_RS16930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6L49_RS16935	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6L49_RS16940	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6L49_RS16945	COG0255	Belongs to the universal ribosomal protein uL29 family
I6L49_RS16950	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6L49_RS16955	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6L49_RS16960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6L49_RS16965	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6L49_RS16970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6L49_RS16975	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6L49_RS16980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6L49_RS16985	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6L49_RS16990	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6L49_RS16995	COG1841	ribosomal large subunit assembly
I6L49_RS17000	COG0200	Binds to the 23S rRNA
I6L49_RS17005	COG0201	protein transport
I6L49_RS17010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L49_RS17015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6L49_RS17020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6L49_RS17025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6L49_RS17030	COG0202	RNA polymerase activity
I6L49_RS17035	COG0203	ribosomal protein L17
I6L49_RS17075	COG4771	TonB-dependent receptor
I6L49_RS17105	COG0583	DNA-binding transcription factor activity
I6L49_RS17115	COG1741	Belongs to the pirin family
I6L49_RS17120	COG2259	Doxx family
I6L49_RS17125	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L49_RS17130	COG1074	ATP-dependent DNA helicase activity
I6L49_RS17135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L49_RS17190	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L49_RS17200	COG3842	ATPase activity
I6L49_RS17230	COG2873	o-acetylhomoserine
I6L49_RS17240	COG4533	DNA binding
I6L49_RS17260	COG5380	lipid catabolic process
I6L49_RS17265	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L49_RS17270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L49_RS17295	COG0753	catalase activity
I6L49_RS17300	COG0454	-acetyltransferase
I6L49_RS17300	COG0456	acetyltransferase
I6L49_RS17325	COG2927	DNA polymerase III (CHI subunit)
I6L49_RS17330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L49_RS17335	COG0795	lipopolysaccharide-transporting ATPase activity
I6L49_RS17340	COG0795	lipopolysaccharide-transporting ATPase activity
I6L49_RS17355	COG0582	viral genome integration into host DNA
I6L49_RS17455	COG1494	fructose-1,6-bisphosphatase
I6L49_RS17470	COG2959	enzyme of heme biosynthesis
I6L49_RS17480	COG0181	hydroxymethylbilane synthase activity
I6L49_RS17485	COG3072	Adenylate cyclase
I6L49_RS17490	COG0400	carboxylic ester hydrolase activity
I6L49_RS17495	COG1965	Belongs to the frataxin family
I6L49_RS17505	COG0019	diaminopimelate decarboxylase activity
I6L49_RS17510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6L49_RS17525	COG1011	Hydrolase
I6L49_RS17545	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6L49_RS17550	COG3028	Belongs to the UPF0307 family
I6L49_RS17555	COG0312	modulator of DNA gyrase
I6L49_RS17560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L49_RS17565	COG5007	Belongs to the BolA IbaG family
I6L49_RS17575	COG2854	intermembrane phospholipid transfer
I6L49_RS17580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L49_RS17585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L49_RS17590	COG1127	ABC transporter
I6L49_RS17595	COG0517	IMP dehydrogenase activity
I6L49_RS17595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L49_RS17600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L49_RS17605	COG3117	lipopolysaccharide transmembrane transporter activity
I6L49_RS17610	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L49_RS17615	COG1137	ATPase activity
I6L49_RS17630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L49_RS17635	COG1660	Displays ATPase and GTPase activities
I6L49_RS17640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L49_RS17645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L49_RS17645	COG3711	transcriptional antiterminator
I6L49_RS17660	COG3964	amidohydrolase
I6L49_RS17690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L49_RS17695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L49_RS17705	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L49_RS17710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L49_RS17715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L49_RS17720	COG0723	plastoquinol--plastocyanin reductase activity
I6L49_RS17725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6L49_RS17730	COG2857	Cytochrome c1
I6L49_RS17735	COG0625	glutathione transferase activity
I6L49_RS17740	COG2969	positive regulation of protein catabolic process
I6L49_RS17750	COG2823	Periplasmic or secreted lipoprotein
I6L49_RS17755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L49_RS17760	COG0792	nuclease activity
I6L49_RS17765	COG3107	peptidoglycan biosynthetic process
I6L49_RS17770	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6L49_RS17780	COG2001	Belongs to the MraZ family
I6L49_RS17785	COG0275	rRNA processing
I6L49_RS17790	COG3116	cell division
I6L49_RS17795	COG0768	penicillin binding
I6L49_RS17805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L49_RS17810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L49_RS17815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6L49_RS17820	COG0772	Belongs to the SEDS family
I6L49_RS17825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6L49_RS17830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L49_RS17840	COG0849	cell division
I6L49_RS17845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L49_RS17850	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6L49_RS17860	COG0653	protein targeting
I6L49_RS17865	COG0494	nUDIX hydrolase
I6L49_RS17870	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L49_RS17875	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6L49_RS17890	COG1459	type II secretion system
I6L49_RS17895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L49_RS17920	COG2186	Transcriptional regulator
I6L49_RS17925	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6L49_RS17930	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L49_RS17935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L49_RS17945	COG0840	transmembrane signaling receptor activity
I6L49_RS17950	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L49_RS17955	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6L49_RS17960	COG2200	EAL domain
I6L49_RS17970	COG0523	cobalamin synthesis protein
I6L49_RS17975	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L49_RS17990	COG2814	Major facilitator Superfamily
I6L49_RS18005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L49_RS18010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6L49_RS18035	COG3314	Sporulation integral membrane protein YlbJ
I6L49_RS18045	COG0165	Argininosuccinate lyase
I6L49_RS18050	COG0137	argininosuccinate synthase activity
I6L49_RS18060	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L49_RS18065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6L49_RS18075	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6L49_RS18090	COG3706	GGDEF domain
I6L49_RS18095	COG0814	amino acid
I6L49_RS18100	COG3932	Exopolysaccharide synthesis, ExoD
I6L49_RS18115	COG0004	ammonium transporteR
I6L49_RS18120	COG3133	Outer membrane lipoprotein
I6L49_RS18125	COG0456	acetyltransferase
I6L49_RS18145	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6L49_RS18150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L49_RS18165	COG0494	nUDIX hydrolase
I6L49_RS18170	COG0628	permease
I6L49_RS18185	COG3284	Transcriptional regulator
I6L49_RS18195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L49_RS18195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L49_RS18195	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6L49_RS18200	COG1461	Dihydroxyacetone kinase
I6L49_RS18205	COG2376	Dihydroxyacetone kinase
I6L49_RS18210	COG2252	PERMEase
I6L49_RS18215	COG1278	Cold shock
I6L49_RS18225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6L49_RS18240	COG2197	response regulator
I6L49_RS18275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6L49_RS18280	COG2199	diguanylate cyclase activity
I6L49_RS18285	COG3047	cAMP biosynthetic process
I6L49_RS18290	COG0840	transmembrane signaling receptor activity
I6L49_RS18315	COG3135	benzoate transporter
I6L49_RS18320	COG1396	sequence-specific DNA binding
I6L49_RS18355	COG2926	Belongs to the UPF0265 family
I6L49_RS18365	COG0561	phosphatase activity
I6L49_RS18375	COG1058	Belongs to the CinA family
I6L49_RS18375	COG1546	Belongs to the CinA family
I6L49_RS18385	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6L49_RS18395	COG1522	sequence-specific DNA binding
I6L49_RS18400	COG1368	sulfuric ester hydrolase activity
I6L49_RS18440	COG4221	oxidoreductase activity
I6L49_RS18455	COG1979	alcohol dehydrogenase
I6L49_RS18460	COG1803	Methylglyoxal synthase
I6L49_RS18485	COG1444	tRNA N-acetyltransferase activity
I6L49_RS18490	COG1028	Short-chain dehydrogenase reductase Sdr
I6L49_RS18495	COG0835	chemotaxis
I6L49_RS18495	COG0784	Response regulator, receiver
I6L49_RS18505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L49_RS18510	COG2949	membrane
I6L49_RS18515	COG3291	Pkd domain containing protein
I6L49_RS18520	COG0318	PFAM AMP-dependent synthetase and ligase
I6L49_RS18525	COG1441	menaquinone biosynthetic process
I6L49_RS18530	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6L49_RS18535	COG0596	Alpha beta hydrolase
I6L49_RS18540	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6L49_RS18545	COG1169	isochorismate synthase
I6L49_RS18550	COG1575	Belongs to the MenA family. Type 1 subfamily
I6L49_RS18570	COG0513	Belongs to the DEAD box helicase family
I6L49_RS18575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L49_RS18580	COG1988	membrane-bound metal-dependent
I6L49_RS18585	COG1671	Belongs to the UPF0178 family
I6L49_RS18605	COG0484	heat shock protein binding
I6L49_RS18615	COG3722	fumarate hydratase activity
I6L49_RS18620	COG0246	Mannitol dehydrogenase
I6L49_RS18625	COG2213	PTS system mannitol-specific
I6L49_RS18625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L49_RS18630	COG1560	Kdo2-lipid A biosynthetic process
I6L49_RS18635	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6L49_RS18635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6L49_RS18640	COG1538	Outer membrane efflux protein
I6L49_RS18645	COG0494	nUDIX hydrolase
I6L49_RS18650	COG3151	Protein conserved in bacteria
I6L49_RS18660	COG3150	esterase
I6L49_RS18665	COG0187	DNA topoisomerase II activity
I6L49_RS18680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L49_RS18700	COG3104	oligopeptide transport
I6L49_RS18740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L49_RS18760	COG0204	Acyl-transferase
I6L49_RS18770	COG1842	Phage shock protein A
I6L49_RS18790	COG2827	Endonuclease containing a URI domain
I6L49_RS18805	COG1573	uracil-dna glycosylase
I6L49_RS18810	COG0697	spore germination
I6L49_RS18815	COG0583	DNA-binding transcription factor activity
I6L49_RS18820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L49_RS18825	COG1121	(ABC) transporter
I6L49_RS18830	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6L49_RS18850	COG0739	heme binding
I6L49_RS18860	COG3068	Protein conserved in bacteria
I6L49_RS18880	COG0617	tRNA 3'-terminal CCA addition
I6L49_RS18885	COG1194	a g-specific adenine glycosylase
I6L49_RS18890	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6L49_RS18900	COG3111	PFAM Bacterial OB fold (BOF) protein
I6L49_RS18905	COG3240	lipase activity
I6L49_RS18910	COG2885	chlorophyll binding
I6L49_RS18910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L49_RS18915	COG3706	GGDEF domain
I6L49_RS18920	COG0557	exoribonuclease II activity
I6L49_RS18925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L49_RS18935	COG2153	protein acetylation
I6L49_RS18940	COG0513	Belongs to the DEAD box helicase family
I6L49_RS18945	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6L49_RS18970	COG0735	belongs to the Fur family
I6L49_RS18975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L49_RS18980	COG0840	transmembrane signaling receptor activity
I6L49_RS18990	COG4166	transmembrane transport
I6L49_RS19000	COG0110	maltose O-acetyltransferase activity
I6L49_RS19010	COG1024	Enoyl-CoA hydratase
I6L49_RS19025	COG4221	oxidoreductase activity
I6L49_RS19030	COG0442	prolyl-tRNA aminoacylation
I6L49_RS19035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L49_RS19045	COG3008	intermembrane lipid transfer
I6L49_RS19045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L49_RS19050	COG2995	paraquat-inducible protein a
I6L49_RS19060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L49_RS19070	COG5001	Diguanylate cyclase
I6L49_RS19070	COG4251	negative regulation of phosphorylation
I6L49_RS19070	COG3706	GGDEF domain
I6L49_RS19070	COG2203	Gaf domain
I6L49_RS19075	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6L49_RS19090	COG2771	luxR family
I6L49_RS19100	COG0840	transmembrane signaling receptor activity
I6L49_RS19105	COG0632	four-way junction helicase activity
I6L49_RS19110	COG2255	four-way junction helicase activity
I6L49_RS19120	COG1294	oxidase, subunit
I6L49_RS19125	COG4890	Cyd operon protein YbgT
I6L49_RS19130	COG3790	cyd operon protein YbgE
I6L49_RS19135	COG0824	Thioesterase
I6L49_RS19140	COG0811	peptide transport
I6L49_RS19155	COG0823	Involved in the tonB-independent uptake of proteins
I6L49_RS19160	COG2885	chlorophyll binding
I6L49_RS19165	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6L49_RS19230	COG0733	neurotransmitter:sodium symporter activity
I6L49_RS19240	COG0733	neurotransmitter:sodium symporter activity
I6L49_RS19255	COG0561	phosphatase activity
I6L49_RS19305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6L49_RS19310	COG1640	4-alpha-glucanotransferase
I6L49_RS19315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L49_RS19320	COG0676	glucose-6-phosphate 1-epimerase activity
I6L49_RS19325	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L49_RS19330	COG0840	transmembrane signaling receptor activity
I6L49_RS19335	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L49_RS19340	COG0330	HflC and HflK could
I6L49_RS19345	COG1648	precorrin-2 dehydrogenase activity
I6L49_RS19345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L49_RS19350	COG0175	sulfate reduction
I6L49_RS19355	COG2895	sulfate adenylyltransferase (ATP) activity
I6L49_RS19360	COG3273	potassium ion transport
I6L49_RS19360	COG0471	metal ion transport
I6L49_RS19365	COG0529	Catalyzes the synthesis of activated sulfate
I6L49_RS19385	COG0840	transmembrane signaling receptor activity
I6L49_RS19405	COG1136	(ABC) transporter
I6L49_RS19420	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6L49_RS19435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L49_RS19440	COG0784	Response regulator, receiver
I6L49_RS19440	COG3437	response regulator, receiver
I6L49_RS19450	COG2076	Multidrug Resistance protein
I6L49_RS19455	COG2076	Multidrug Resistance protein
I6L49_RS19460	COG0346	lactoylglutathione lyase activity
I6L49_RS19465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L49_RS19470	COG1643	Atp-dependent helicase
I6L49_RS19480	COG1489	DNA binding
I6L49_RS19485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L49_RS19490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L49_RS19500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L49_RS19505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6L49_RS19510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6L49_RS19520	COG1823	symporter activity
I6L49_RS19540	COG1924	4 iron, 4 sulfur cluster binding
I6L49_RS19545	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6L49_RS19550	COG0842	Transport permease protein
I6L49_RS19555	COG1131	(ABC) transporter
I6L49_RS19570	COG0163	prenyltransferase activity
I6L49_RS19575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L49_RS19580	COG0671	phosphoesterase, PA-phosphatase related
I6L49_RS19585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L49_RS19590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L49_RS19595	COG1151	hydroxylamine reductase activity
I6L49_RS19600	COG0783	Belongs to the Dps family
I6L49_RS19605	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L49_RS19610	COG4807	Protein conserved in bacteria
I6L49_RS19620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L49_RS19625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L49_RS19630	COG3956	TIGRFAM MazG family protein
I6L49_RS19635	COG0504	CTP synthase activity
I6L49_RS19640	COG0148	phosphopyruvate hydratase activity
I6L49_RS19690	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L49_RS19700	COG0488	(ABC) transporter
I6L49_RS19720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L49_RS19735	COG1794	racemase activity, acting on amino acids and derivatives
I6L49_RS19745	COG2731	YhcH YjgK YiaL family protein
I6L49_RS19755	COG0668	transmembrane transport
I6L49_RS19760	COG1376	ErfK ybiS ycfS ynhG family protein
I6L49_RS19770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L49_RS19775	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L49_RS19780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6L49_RS19790	COG0585	pseudouridine synthase activity
I6L49_RS19795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L49_RS19800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6L49_RS19805	COG1238	metal cluster binding
I6L49_RS19820	COG1902	pentaerythritol trinitrate reductase activity
I6L49_RS19835	COG2957	Belongs to the agmatine deiminase family
I6L49_RS19860	COG0513	Belongs to the DEAD box helicase family
I6L49_RS19865	COG2203	Gaf domain
I6L49_RS19865	COG2199	diguanylate cyclase activity
I6L49_RS19875	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6L49_RS19880	COG1858	cytochrome C peroxidase
I6L49_RS19925	COG2816	NAD+ diphosphatase activity
I6L49_RS19960	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L49_RS19970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L49_RS19975	COG4991	sh3 domain protein
I6L49_RS19985	COG2816	NAD+ diphosphatase activity
I6L49_RS19990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6L49_RS19995	COG1940	carbohydrate kinase activity
I6L49_RS20000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L49_RS20005	COG0126	phosphoglycerate kinase activity
I6L49_RS20015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L49_RS20060	COG0354	folic acid binding
I6L49_RS20065	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L49_RS20075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6L49_RS20080	COG1595	DNA-templated transcription, initiation
I6L49_RS20085	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6L49_RS20090	COG3026	antisigma factor binding
I6L49_RS20100	COG0481	GTPase activity
I6L49_RS20105	COG0681	Belongs to the peptidase S26 family
I6L49_RS20120	COG1381	Involved in DNA repair and RecF pathway recombination
I6L49_RS20125	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L49_RS20135	COG2350	Protein conserved in bacteria
I6L49_RS20140	COG2917	probably involved in intracellular septation
I6L49_RS20145	COG0076	glutamate decarboxylase activity
I6L49_RS20150	COG1272	protein, Hemolysin III
I6L49_RS20155	COG2985	domain, Protein
I6L49_RS20155	COG0569	domain protein
I6L49_RS20175	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6L49_RS20200	COG2313	pseudouridylate synthase activity
I6L49_RS20205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L49_RS20245	COG1765	OsmC-like protein
I6L49_RS20260	COG3954	Phosphoribulokinase
I6L49_RS20265	COG3089	Belongs to the UPF0270 family
I6L49_RS20270	COG2203	Gaf domain
I6L49_RS20270	COG3706	GGDEF domain
I6L49_RS20270	COG4251	negative regulation of phosphorylation
I6L49_RS20270	COG5001	Diguanylate cyclase
I6L49_RS20275	COG0429	hydrolase of the alpha beta-hydrolase fold
I6L49_RS20280	COG0784	Response regulator, receiver
I6L49_RS20280	COG0835	chemotaxis
I6L49_RS20290	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L49_RS20295	COG1047	Peptidyl-prolyl cis-trans
I6L49_RS20310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L49_RS20335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L49_RS20345	COG3721	Heme iron utilization protein
I6L49_RS20350	COG0748	coenzyme F420 binding
I6L49_RS20375	COG2814	Major facilitator Superfamily
I6L49_RS20385	COG3655	Transcriptional regulator
I6L49_RS20395	COG2205	protein histidine kinase activity
I6L49_RS20395	COG0784	Response regulator, receiver
I6L49_RS20395	COG5002	protein histidine kinase activity
I6L49_RS20415	COG3397	chitin binding
I6L49_RS20455	COG0784	Response regulator, receiver
I6L49_RS20455	COG0835	chemotaxis
I6L49_RS20460	COG2755	lipolytic protein G-D-S-L family
I6L49_RS20465	COG4181	ATPase activity
I6L49_RS20470	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L49_RS20475	COG1090	epimerase
I6L49_RS20480	COG2200	EAL domain
I6L49_RS20485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L49_RS20490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L49_RS20495	COG3171	Protein conserved in bacteria
I6L49_RS20500	COG2066	Belongs to the glutaminase family
I6L49_RS20505	COG2897	thiosulfate sulfurtransferase activity
I6L49_RS20520	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L49_RS20530	COG2966	Psort location CytoplasmicMembrane, score
I6L49_RS20535	COG3610	response to peptide
I6L49_RS20545	COG0175	sulfate reduction
I6L49_RS20550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L49_RS20555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L49_RS20560	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L49_RS20575	COG0786	glutamate:sodium symporter activity
I6L49_RS20580	COG0252	asparaginase activity
I6L49_RS20585	COG3139	Protein of unknown function (DUF1315)
I6L49_RS20605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L49_RS20610	COG0321	lipoyl(octanoyl) transferase activity
I6L49_RS20615	COG2921	Belongs to the UPF0250 family
I6L49_RS20620	COG1686	Belongs to the peptidase S11 family
I6L49_RS20625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L49_RS20630	COG2951	lytic endotransglycosylase activity
I6L49_RS20635	COG0772	Belongs to the SEDS family
I6L49_RS20640	COG0768	penicillin binding
I6L49_RS20645	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6L49_RS20650	COG0799	negative regulation of ribosome biogenesis
I6L49_RS20655	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6L49_RS20670	COG0495	leucyl-tRNA aminoacylation
I6L49_RS20675	COG2888	peptidyl-tyrosine sulfation
I6L49_RS20680	COG0312	modulator of DNA gyrase
I6L49_RS20690	COG0716	FMN binding
I6L49_RS20695	COG4974	Belongs to the 'phage' integrase family
I6L49_RS20700	COG1970	mechanosensitive ion channel activity
I6L49_RS20710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L49_RS20715	COG0789	Transcriptional regulator
I6L49_RS20725	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L49_RS20730	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6L49_RS20735	COG4535	Mg2 and Co2 transporter CorC
I6L49_RS20740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6L49_RS20745	COG1702	phosphate starvation-inducible protein PhoH
I6L49_RS20750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L49_RS20755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L49_RS20760	COG1335	isochorismatase
I6L49_RS20770	COG3706	GGDEF domain
I6L49_RS20775	COG0583	DNA-binding transcription factor activity
I6L49_RS20800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L49_RS20810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L49_RS20820	COG0516	GMP reductase activity
I6L49_RS20830	COG0642	Histidine kinase
I6L49_RS20845	COG4221	oxidoreductase activity
I6L49_RS20870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L49_RS20880	COG1309	transcriptional regulator
I6L49_RS20885	COG3214	Protein conserved in bacteria
I6L49_RS20895	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L49_RS20900	COG0700	Nucleoside recognition
I6L49_RS20905	COG3366	ferrous iron transmembrane transporter activity
I6L49_RS20910	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L49_RS20915	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L49_RS20920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L49_RS20925	COG1053	succinate dehydrogenase
I6L49_RS20935	COG0584	glycerophosphoryl diester phosphodiesterase
I6L49_RS20940	COG1511	domain protein
I6L49_RS20940	COG3264	Mechanosensitive ion channel
I6L49_RS20950	COG0739	heme binding
I6L49_RS20960	COG0583	DNA-binding transcription factor activity