locus-tag	class	description
O23A_RS00005	COG0784	Response regulator, receiver
O23A_RS00005	COG0835	chemotaxis
O23A_RS00010	COG2755	lipolytic protein G-D-S-L family
O23A_RS00015	COG4181	ATPase activity
O23A_RS00020	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
O23A_RS00025	COG1090	epimerase
O23A_RS00030	COG2200	EAL domain
O23A_RS00035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O23A_RS00040	COG2234	aminopeptidase activity
O23A_RS00040	COG4935	Belongs to the peptidase S8 family
O23A_RS00045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O23A_RS00050	COG3171	Protein conserved in bacteria
O23A_RS00055	COG2066	Belongs to the glutaminase family
O23A_RS00060	COG2897	thiosulfate sulfurtransferase activity
O23A_RS00070	COG1132	(ABC) transporter
O23A_RS00080	COG1012	belongs to the aldehyde dehydrogenase family
O23A_RS00085	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
O23A_RS00115	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
O23A_RS00120	COG5001	Diguanylate cyclase
O23A_RS00120	COG3300	MHYT domain
O23A_RS00140	COG4628	conserved protein (DUF2132)
O23A_RS00145	COG0688	phosphatidylethanolamine metabolic process
O23A_RS00150	COG1162	GTPase activity
O23A_RS00155	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
O23A_RS00195	COG1278	Cold shock
O23A_RS00205	COG0840	transmembrane signaling receptor activity
O23A_RS00210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O23A_RS00215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O23A_RS00265	COG0848	biopolymer transport protein
O23A_RS00270	COG0811	peptide transport
O23A_RS00275	COG0811	peptide transport
O23A_RS00285	COG4206	TonB-dependent receptor
O23A_RS00290	COG4174	ABC transporter (Permease)
O23A_RS00295	COG4239	(ABC) transporter, permease
O23A_RS00300	COG0747	negative chemotaxis
O23A_RS00305	COG0444	Belongs to the ABC transporter superfamily
O23A_RS00310	COG4608	Belongs to the ABC transporter superfamily
O23A_RS00320	COG2195	Cleaves the N-terminal amino acid of tripeptides
O23A_RS00335	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
O23A_RS00340	COG1073	alpha beta
O23A_RS00350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O23A_RS00355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O23A_RS00380	COG0243	molybdopterin cofactor binding
O23A_RS00395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O23A_RS00400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O23A_RS00405	COG1116	anion transmembrane transporter activity
O23A_RS00410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O23A_RS00410	COG2146	nitrite reductase [NAD(P)H] activity
O23A_RS00415	COG2146	nitrite reductase [NAD(P)H] activity
O23A_RS00415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O23A_RS00420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O23A_RS00425	COG2313	pseudouridylate synthase activity
O23A_RS00435	COG1858	cytochrome C peroxidase
O23A_RS00470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O23A_RS00475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O23A_RS00485	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_RS00500	COG2986	histidine ammonia-lyase
O23A_RS00525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O23A_RS00535	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS00540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O23A_RS00550	COG0521	Mo-molybdopterin cofactor biosynthetic process
O23A_RS00560	COG2966	Psort location CytoplasmicMembrane, score
O23A_RS00565	COG3610	response to peptide
O23A_RS00575	COG4175	Glycine betaine
O23A_RS00580	COG4176	ABC-type proline glycine betaine transport system permease component
O23A_RS00585	COG2113	Glycine betaine
O23A_RS00590	COG0175	sulfate reduction
O23A_RS00595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O23A_RS00600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O23A_RS00605	COG0384	phenazine biosynthesis protein PhzF
O23A_RS00610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O23A_RS00625	COG0786	glutamate:sodium symporter activity
O23A_RS00630	COG0252	asparaginase activity
O23A_RS00640	COG3139	Protein of unknown function (DUF1315)
O23A_RS00660	COG0616	signal peptide processing
O23A_RS00665	COG1902	pentaerythritol trinitrate reductase activity
O23A_RS00665	COG0446	pyridine nucleotide-disulphide oxidoreductase
O23A_RS00670	COG0778	Nitroreductase
O23A_RS00675	COG0110	maltose O-acetyltransferase activity
O23A_RS00680	COG2264	protein methyltransferase activity
O23A_RS00685	COG0604	alcohol dehydrogenase
O23A_RS00690	COG0583	DNA-binding transcription factor activity
O23A_RS00695	COG2190	(PTS) system
O23A_RS00695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O23A_RS00695	COG1263	PTS System
O23A_RS00700	COG4145	pantothenate transmembrane transporter activity
O23A_RS00705	COG3924	membrane
O23A_RS00710	COG0439	Biotin carboxylase
O23A_RS00715	COG0511	ligase activity, forming carbon-carbon bonds
O23A_RS00720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O23A_RS00725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O23A_RS00755	COG3381	protein complex oligomerization
O23A_RS00770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O23A_RS00785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O23A_RS00790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O23A_RS00790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O23A_RS00805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O23A_RS00810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O23A_RS00815	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O23A_RS00820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O23A_RS00825	COG4172	Belongs to the ABC transporter superfamily
O23A_RS00835	COG0601	transmembrane transport
O23A_RS00845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O23A_RS00850	COG0142	geranyltranstransferase activity
O23A_RS00855	COG1722	exodeoxyribonuclease VII activity
O23A_RS00860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O23A_RS00865	COG1360	Flagellar Motor Protein
O23A_RS00890	COG1534	Rna-binding protein
O23A_RS00895	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
O23A_RS00905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O23A_RS00910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O23A_RS00915	COG0149	triose-phosphate isomerase activity
O23A_RS00920	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O23A_RS00935	COG0779	Required for maturation of 30S ribosomal subunits
O23A_RS00940	COG0195	Participates in both transcription termination and antitermination
O23A_RS00945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O23A_RS00950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O23A_RS00955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O23A_RS00960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O23A_RS00965	COG1185	polyribonucleotide nucleotidyltransferase activity
O23A_RS00970	COG2211	Major facilitator Superfamily
O23A_RS00975	COG3706	GGDEF domain
O23A_RS00980	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
O23A_RS00985	COG1422	Protein of unknown function (DUF1090)
O23A_RS00990	COG0114	fumarate hydratase activity
O23A_RS00995	COG2197	response regulator
O23A_RS01085	COG0312	modulator of DNA gyrase
O23A_RS01100	COG4974	Belongs to the 'phage' integrase family
O23A_RS01105	COG1970	mechanosensitive ion channel activity
O23A_RS01115	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O23A_RS01130	COG3545	Serine hydrolase
O23A_RS01135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_RS01140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O23A_RS01150	COG0321	lipoyl(octanoyl) transferase activity
O23A_RS01155	COG2921	Belongs to the UPF0250 family
O23A_RS01160	COG1686	Belongs to the peptidase S11 family
O23A_RS01165	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O23A_RS01170	COG2951	lytic endotransglycosylase activity
O23A_RS01175	COG0772	Belongs to the SEDS family
O23A_RS01180	COG0768	penicillin binding
O23A_RS01185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O23A_RS01190	COG0799	negative regulation of ribosome biogenesis
O23A_RS01195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O23A_RS01215	COG0495	leucyl-tRNA aminoacylation
O23A_RS01220	COG2888	peptidyl-tyrosine sulfation
O23A_RS01225	COG0815	Transfers the fatty acyl group on membrane lipoproteins
O23A_RS01230	COG4535	Mg2 and Co2 transporter CorC
O23A_RS01235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O23A_RS01240	COG1702	phosphate starvation-inducible protein PhoH
O23A_RS01245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O23A_RS01250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O23A_RS01260	COG3706	GGDEF domain
O23A_RS01275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O23A_RS01305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O23A_RS01315	COG0516	GMP reductase activity
O23A_RS01325	COG0642	Histidine kinase
O23A_RS01350	COG1022	Amp-dependent synthetase and ligase
O23A_RS01365	COG3214	Protein conserved in bacteria
O23A_RS01385	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
O23A_RS01390	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
O23A_RS01395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O23A_RS01400	COG1053	succinate dehydrogenase
O23A_RS01415	COG0584	glycerophosphoryl diester phosphodiesterase
O23A_RS01420	COG1511	domain protein
O23A_RS01420	COG3264	Mechanosensitive ion channel
O23A_RS01430	COG0739	heme binding
O23A_RS01445	COG0583	DNA-binding transcription factor activity
O23A_RS01460	COG0840	transmembrane signaling receptor activity
O23A_RS01465	COG0583	DNA-binding transcription factor activity
O23A_RS01470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
O23A_RS01500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O23A_RS01505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O23A_RS01515	COG0338	D12 class N6 adenine-specific DNA methyltransferase
O23A_RS01520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O23A_RS01525	COG0546	phosphoglycolate phosphatase activity
O23A_RS01530	COG0180	Tryptophanyl-tRNA synthetase
O23A_RS01545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O23A_RS01555	COG1012	belongs to the aldehyde dehydrogenase family
O23A_RS01565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O23A_RS01575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_RS01575	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
O23A_RS01575	COG0674	pyruvate-flavodoxin oxidoreductase activity
O23A_RS01575	COG1013	pyruvate-flavodoxin oxidoreductase activity
O23A_RS01585	COG0488	(ABC) transporter
O23A_RS01600	COG0366	Alpha amylase catalytic
O23A_RS01620	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
O23A_RS01630	COG0490	domain, Protein
O23A_RS01630	COG0471	metal ion transport
O23A_RS01670	COG0012	GTP binding
O23A_RS01675	COG0193	aminoacyl-tRNA hydrolase activity
O23A_RS01680	COG0737	Belongs to the 5'-nucleotidase family
O23A_RS01685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O23A_RS01695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O23A_RS01700	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
O23A_RS01705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O23A_RS01710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O23A_RS01715	COG2890	protein-(glutamine-N5) methyltransferase activity
O23A_RS01725	COG2912	Transglutaminase-like superfamily
O23A_RS01735	COG1301	dicarboxylic acid transport
O23A_RS01750	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O23A_RS01765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O23A_RS01770	COG1115	amino acid carrier protein
O23A_RS01785	COG0714	Associated with various cellular activities
O23A_RS01805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O23A_RS01810	COG1678	Uncharacterized ACR, COG1678
O23A_RS01820	COG0189	ligase activity
O23A_RS01825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O23A_RS01835	COG3091	SprT-like family
O23A_RS01845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O23A_RS01860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
O23A_RS01865	COG0739	heme binding
O23A_RS01870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O23A_RS01885	COG0463	Glycosyl transferase, family 2
O23A_RS01900	COG2989	Protein conserved in bacteria
O23A_RS01905	COG3108	Peptidase M15
O23A_RS01915	COG2860	membrane
O23A_RS01925	COG1196	nuclear chromosome segregation
O23A_RS01930	COG3115	cell septum assembly
O23A_RS01935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O23A_RS01945	COG1328	CTP reductase activity
O23A_RS01950	COG0602	queuosine metabolic process
O23A_RS01975	COG1566	PFAM secretion protein HlyD family protein
O23A_RS01980	COG1846	Transcriptional regulator
O23A_RS01995	COG0281	malic enzyme
O23A_RS02000	COG3290	protein histidine kinase activity
O23A_RS02015	COG0667	Aldo Keto reductase
O23A_RS02025	COG0697	spore germination
O23A_RS02040	COG3284	Transcriptional regulator
O23A_RS02045	COG3706	GGDEF domain
O23A_RS02050	COG0346	lactoylglutathione lyase activity
O23A_RS02055	COG0745	RESPONSE REGULATOR receiver
O23A_RS02060	COG5002	protein histidine kinase activity
O23A_RS02080	COG1940	carbohydrate kinase activity
O23A_RS02085	COG3142	Participates in the control of copper homeostasis
O23A_RS02090	COG0545	Peptidyl-prolyl cis-trans isomerase
O23A_RS02095	COG1131	(ABC) transporter
O23A_RS02135	COG0019	diaminopimelate decarboxylase activity
O23A_RS02140	COG1115	amino acid carrier protein
O23A_RS02145	COG0095	Lipoate-protein ligase
O23A_RS02150	COG2233	PERMEase
O23A_RS02165	COG0534	Mate efflux family protein
O23A_RS02170	COG2207	Transcriptional regulator
O23A_RS02175	COG0281	malic enzyme
O23A_RS02205	COG0733	neurotransmitter:sodium symporter activity
O23A_RS02210	COG1752	Esterase of the alpha-beta hydrolase superfamily
O23A_RS02215	COG3706	GGDEF domain
O23A_RS02220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_RS02225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_RS02235	COG1032	radical SAM domain protein
O23A_RS02260	COG0673	inositol 2-dehydrogenase activity
O23A_RS02265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
O23A_RS02270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O23A_RS02275	COG0739	heme binding
O23A_RS02275	COG1196	nuclear chromosome segregation
O23A_RS02275	COG0741	lytic transglycosylase activity
O23A_RS02280	COG0366	Alpha amylase catalytic
O23A_RS02300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O23A_RS02310	COG0788	formyltetrahydrofolate deformylase activity
O23A_RS02315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O23A_RS02325	COG3118	belongs to the thioredoxin family
O23A_RS02330	COG2091	lysine biosynthetic process via aminoadipic acid
O23A_RS02335	COG0791	NLP P60 protein
O23A_RS02340	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
O23A_RS02355	COG1376	ErfK ybiS ycfS ynhG family protein
O23A_RS02355	COG1388	LysM domain
O23A_RS02410	COG3311	Transcriptional regulator
O23A_RS02480	COG2003	Belongs to the UPF0758 family
O23A_RS02530	COG1518	maintenance of DNA repeat elements
O23A_RS02535	COG1203	CRISPR-associated helicase, Cas3
O23A_RS02565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O23A_RS02575	COG1960	acyl-CoA dehydrogenase activity
O23A_RS02580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_RS02590	COG0469	pyruvate kinase activity
O23A_RS02595	COG1737	Transcriptional regulator
O23A_RS02615	COG2274	protein secretion by the type I secretion system
O23A_RS02625	COG2274	protein secretion by the type I secretion system
O23A_RS02635	COG2994	toxin metabolic process
O23A_RS02640	COG1073	alpha beta
O23A_RS02640	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
O23A_RS02640	COG3064	Membrane
O23A_RS02655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O23A_RS02665	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS02675	COG1414	Transcriptional regulator
O23A_RS02680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O23A_RS02685	COG0800	Aldolase
O23A_RS02690	COG2731	YhcH YjgK YiaL family protein
O23A_RS02715	COG1342	Belongs to the UPF0251 family
O23A_RS02730	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O23A_RS02740	COG1677	Flagellar hook-basal body complex protein FliE
O23A_RS02750	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O23A_RS02805	COG1684	flagellar biosynthetic protein fliR
O23A_RS02815	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O23A_RS02840	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
O23A_RS02845	COG0643	Histidine kinase
O23A_RS02845	COG0784	Response regulator, receiver
O23A_RS02845	COG2198	Histidine kinase
O23A_RS02850	COG2201	protein-glutamate methylesterase activity
O23A_RS02855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O23A_RS02860	COG1360	Flagellar Motor Protein
O23A_RS02875	COG0835	chemotaxis
O23A_RS02890	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O23A_RS02895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O23A_RS02900	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O23A_RS02905	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
O23A_RS02910	COG1138	Cytochrome C-type biogenesis protein
O23A_RS02915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O23A_RS02920	COG3088	subunit of a heme lyase
O23A_RS02920	COG4235	cytochrome complex assembly
O23A_RS02925	COG4235	cytochrome complex assembly
O23A_RS02925	COG3088	subunit of a heme lyase
O23A_RS02940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
O23A_RS02945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O23A_RS02945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O23A_RS02960	COG0259	pyridoxamine-phosphate oxidase activity
O23A_RS02975	COG3153	acetyltransferase
O23A_RS02985	COG2850	peptidyl-arginine hydroxylation
O23A_RS02990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O23A_RS02995	COG2915	High frequency lysogenization protein hflD homolog
O23A_RS03000	COG0482	sulfurtransferase activity
O23A_RS03020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_RS03030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_RS03030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_RS03030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_RS03055	COG0783	Belongs to the Dps family
O23A_RS03065	COG1988	membrane-bound metal-dependent
O23A_RS03090	COG0159	tryptophan synthase activity
O23A_RS03095	COG0133	tryptophan synthase activity
O23A_RS03100	COG0134	indole-3-glycerol-phosphate synthase activity
O23A_RS03100	COG0135	phosphoribosylanthranilate isomerase activity
O23A_RS03105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O23A_RS03110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O23A_RS03110	COG0512	Glutamine amidotransferase of anthranilate synthase
O23A_RS03115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O23A_RS03125	COG0009	L-threonylcarbamoyladenylate synthase
O23A_RS03135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O23A_RS03145	COG1946	Acyl-CoA thioesterase
O23A_RS03160	COG1309	transcriptional regulator
O23A_RS03165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_RS03170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_RS03185	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
O23A_RS03240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O23A_RS03250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O23A_RS03270	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
O23A_RS03280	COG3132	Protein of unknown function, DUF480
O23A_RS03320	COG1278	Cold shock
O23A_RS03345	COG4166	transmembrane transport
O23A_RS03350	COG0697	spore germination
O23A_RS03375	COG4166	transmembrane transport
O23A_RS03380	COG0622	Phosphoesterase
O23A_RS03400	COG0835	chemotaxis
O23A_RS03400	COG0784	Response regulator, receiver
O23A_RS03405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O23A_RS03410	COG1815	bacterial-type flagellum-dependent cell motility
O23A_RS03430	COG4787	bacterial-type flagellum-dependent cell motility
O23A_RS03440	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
O23A_RS03445	COG1706	bacterial-type flagellum-dependent cell motility
O23A_RS03465	COG2239	Acts as a magnesium transporter
O23A_RS03470	COG0248	Ppx GppA phosphatase
O23A_RS03475	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
O23A_RS03505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O23A_RS03510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O23A_RS03515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O23A_RS03520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O23A_RS03540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O23A_RS03550	COG0590	tRNA wobble adenosine to inosine editing
O23A_RS03555	COG0573	inorganic phosphate transmembrane transporter activity
O23A_RS03560	COG0581	inorganic phosphate transmembrane transporter activity
O23A_RS03565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O23A_RS03570	COG0704	Plays a role in the regulation of phosphate uptake
O23A_RS03575	COG1253	flavin adenine dinucleotide binding
O23A_RS03590	COG0531	amino acid
O23A_RS03600	COG1126	abc transporter atp-binding protein
O23A_RS03605	COG0765	amino acid transport
O23A_RS03610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_RS03615	COG3706	GGDEF domain
O23A_RS03620	COG2271	Major facilitator Superfamily
O23A_RS03635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O23A_RS03655	COG1785	Belongs to the alkaline phosphatase family
O23A_RS03660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O23A_RS03665	COG0123	including yeast histone deacetylase and acetoin utilization protein
O23A_RS03675	COG1199	ATP-dependent helicase activity
O23A_RS03690	COG1448	Aminotransferase
O23A_RS03695	COG0433	COG0433 Predicted ATPase
O23A_RS03710	COG0658	competence protein
O23A_RS03710	COG2333	competence protein COMEC
O23A_RS03715	COG1132	(ABC) transporter
O23A_RS03720	COG1663	tetraacyldisaccharide 4'-kinase activity
O23A_RS03725	COG2835	tetraacyldisaccharide 4'-kinase activity
O23A_RS03730	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
O23A_RS03735	COG2197	response regulator
O23A_RS03740	COG0322	excinuclease ABC activity
O23A_RS03840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O23A_RS03890	COG4695	Portal protein
O23A_RS03985	COG4974	Belongs to the 'phage' integrase family
O23A_RS04025	COG2261	transglycosylase associated protein
O23A_RS04030	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O23A_RS04040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O23A_RS04075	COG2203	Gaf domain
O23A_RS04075	COG2199	diguanylate cyclase activity
O23A_RS04105	COG2119	membrane
O23A_RS04150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_RS04150	COG2205	protein histidine kinase activity
O23A_RS04160	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
O23A_RS04170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O23A_RS04175	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O23A_RS04180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O23A_RS04185	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
O23A_RS04190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O23A_RS04205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O23A_RS04210	COG0505	Belongs to the CarA family
O23A_RS04215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O23A_RS04220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O23A_RS04230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
O23A_RS04250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_RS04255	COG0513	Belongs to the DEAD box helicase family
O23A_RS04265	COG4104	PAAR repeat-containing protein
O23A_RS04280	COG0789	Transcriptional regulator
O23A_RS04295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_RS04300	COG0765	amino acid transport
O23A_RS04305	COG1126	abc transporter atp-binding protein
O23A_RS04310	COG0493	'glutamate synthase
O23A_RS04315	COG0069	glutamate synthase activity
O23A_RS04315	COG0067	glutamate synthase
O23A_RS04315	COG0070	glutamate synthase
O23A_RS04320	COG1242	4 iron, 4 sulfur cluster binding
O23A_RS04400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O23A_RS04405	COG0574	Belongs to the PEP-utilizing enzyme family
O23A_RS04405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O23A_RS04445	COG1464	Belongs to the NlpA lipoprotein family
O23A_RS04450	COG0671	phosphoesterase, PA-phosphatase related
O23A_RS04455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O23A_RS04460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O23A_RS04470	COG0101	tRNA pseudouridine synthase activity
O23A_RS04475	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O23A_RS04480	COG0285	dihydrofolate synthase activity
O23A_RS04485	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
O23A_RS04490	COG2920	part of a sulfur-relay system
O23A_RS04495	COG1289	transmembrane transporter activity
O23A_RS04500	COG0670	Belongs to the BI1 family
O23A_RS04510	COG0840	transmembrane signaling receptor activity
O23A_RS04515	COG5001	Diguanylate cyclase
O23A_RS04520	COG0564	pseudouridine synthase activity
O23A_RS04535	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
O23A_RS04545	COG0625	glutathione transferase activity
O23A_RS04555	COG0367	asparagine synthase
O23A_RS04565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O23A_RS04565	COG4651	solute:proton antiporter activity
O23A_RS04570	COG0647	UMP catabolic process
O23A_RS04580	COG1902	pentaerythritol trinitrate reductase activity
O23A_RS04585	COG1253	flavin adenine dinucleotide binding
O23A_RS04595	COG0247	lactate metabolic process
O23A_RS04595	COG0277	FAD linked oxidase domain protein
O23A_RS04605	COG2050	protein possibly involved in aromatic compounds catabolism
O23A_RS04610	COG0513	Belongs to the DEAD box helicase family
O23A_RS04620	COG3300	MHYT domain
O23A_RS04620	COG5001	Diguanylate cyclase
O23A_RS04625	COG2056	Na+-H+ antiporter family
O23A_RS04630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O23A_RS04645	COG0346	lactoylglutathione lyase activity
O23A_RS04650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O23A_RS04655	COG4660	Part of a membrane complex involved in electron transport
O23A_RS04660	COG4659	FMN binding
O23A_RS04665	COG4658	electron transport chain
O23A_RS04675	COG2878	Part of a membrane complex involved in electron transport
O23A_RS04680	COG4657	Part of a membrane complex involved in electron transport
O23A_RS04685	COG0697	spore germination
O23A_RS04700	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O23A_RS04705	COG1288	antiporter activity
O23A_RS04710	COG0436	Aminotransferase
O23A_RS04720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O23A_RS04725	COG2027	D-alanyl-D-alanine carboxypeptidase
O23A_RS04730	COG1061	Type III restriction enzyme res subunit
O23A_RS04735	COG1566	PFAM secretion protein HlyD family protein
O23A_RS04745	COG1966	Carbon starvation protein
O23A_RS04750	COG3279	Response regulator of the LytR AlgR family
O23A_RS04755	COG3275	phosphorelay sensor kinase activity
O23A_RS04765	COG1012	belongs to the aldehyde dehydrogenase family
O23A_RS04765	COG1454	alcohol dehydrogenase
O23A_RS04775	COG2095	MarC family integral membrane protein
O23A_RS04785	COG0601	transmembrane transport
O23A_RS04790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O23A_RS04795	COG0444	Belongs to the ABC transporter superfamily
O23A_RS04805	COG0861	Integral membrane protein TerC family
O23A_RS04810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O23A_RS04820	COG1301	dicarboxylic acid transport
O23A_RS04835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O23A_RS04850	COG0537	adenosine 5'-monophosphoramidase activity
O23A_RS04885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O23A_RS04890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O23A_RS04905	COG1007	ATP synthesis coupled electron transport
O23A_RS04910	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_RS04920	COG0713	ATP synthesis coupled electron transport
O23A_RS04925	COG0839	Belongs to the complex I subunit 6 family
O23A_RS04930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_RS04935	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O23A_RS04940	COG1034	ATP synthesis coupled electron transport
O23A_RS04955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_RS04955	COG0649	NAD binding
O23A_RS04960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_RS04965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_RS04970	COG1360	Flagellar Motor Protein
O23A_RS04975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O23A_RS04995	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
O23A_RS05010	COG4597	amino acid ABC transporter
O23A_RS05015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_RS05020	COG0765	amino acid transport
O23A_RS05025	COG1126	abc transporter atp-binding protein
O23A_RS05035	COG0724	RNA recognition motif
O23A_RS05040	COG4989	oxidoreductase activity
O23A_RS05065	COG3437	response regulator, receiver
O23A_RS05070	COG0583	DNA-binding transcription factor activity
O23A_RS05080	COG5001	Diguanylate cyclase
O23A_RS05080	COG3300	MHYT domain
O23A_RS05115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O23A_RS05120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O23A_RS05125	COG0539	negative regulation of cytoplasmic translation
O23A_RS05130	COG0776	regulation of translation
O23A_RS05140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
O23A_RS05145	COG0284	orotidine-5'-phosphate decarboxylase activity
O23A_RS05160	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O23A_RS05165	COG0602	queuosine metabolic process
O23A_RS05170	COG3530	Putative quorum-sensing-regulated virulence factor
O23A_RS05175	COG2096	Adenosyltransferase
O23A_RS05180	COG2916	Histone family protein nucleoid-structuring protein H-NS
O23A_RS05185	COG1757	Na H antiporter
O23A_RS05190	COG1435	thymidine kinase activity
O23A_RS05210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O23A_RS05215	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
O23A_RS05220	COG0437	4 iron, 4 sulfur cluster binding
O23A_RS05225	COG5557	Pfam Polysulphide reductase, NrfD
O23A_RS05230	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
O23A_RS05235	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
O23A_RS05240	COG1773	rubredoxin
O23A_RS05250	COG0601	transmembrane transport
O23A_RS05255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O23A_RS05265	COG1124	(ABC) transporter
O23A_RS05270	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
O23A_RS05275	COG0375	protein maturation
O23A_RS05280	COG0309	Hydrogenase expression formation protein (HypE)
O23A_RS05290	COG0298	carbon dioxide binding
O23A_RS05295	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
O23A_RS05305	COG1921	L-seryl-tRNASec selenium transferase activity
O23A_RS05320	COG3260	NADH ubiquinone oxidoreductase 20
O23A_RS05325	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O23A_RS05330	COG3261	NADH dehydrogenase
O23A_RS05330	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
O23A_RS05335	COG0650	Formate hydrogenlyase subunit 4
O23A_RS05340	COG0651	ATP synthesis coupled electron transport
O23A_RS05345	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
O23A_RS05350	COG3158	transport of potassium into the cell
O23A_RS05360	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
O23A_RS05385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O23A_RS05390	COG0326	Molecular chaperone. Has ATPase activity
O23A_RS05400	COG0563	adenylate kinase activity
O23A_RS05405	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O23A_RS05410	COG3788	relative of glutathione S-transferase, MAPEG superfamily
O23A_RS05415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O23A_RS05420	COG0840	transmembrane signaling receptor activity
O23A_RS05435	COG3300	MHYT domain
O23A_RS05435	COG5001	Diguanylate cyclase
O23A_RS05440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O23A_RS05460	COG1021	2,3-dihydroxybenzoate-AMP ligase
O23A_RS05465	COG3433	isochorismatase activity
O23A_RS05465	COG1535	isochorismatase
O23A_RS05470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O23A_RS05475	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS05485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O23A_RS05485	COG0300	oxidoreductase activity
O23A_RS05485	COG3321	synthase
O23A_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS05485	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_RS05495	COG2977	Belongs to the P-Pant transferase superfamily
O23A_RS05500	COG1120	ATPase activity
O23A_RS05505	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O23A_RS05510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O23A_RS05515	COG4771	TonB-dependent receptor
O23A_RS05560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O23A_RS05565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O23A_RS05570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O23A_RS05585	COG1570	exodeoxyribonuclease VII activity
O23A_RS05590	COG3038	cytochrome b561
O23A_RS05610	COG0516	GMP reductase activity
O23A_RS05610	COG0517	IMP dehydrogenase activity
O23A_RS05615	COG0519	Catalyzes the synthesis of GMP from XMP
O23A_RS05615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O23A_RS05650	COG2062	phosphohistidine phosphatase, SixA
O23A_RS05660	COG0697	spore germination
O23A_RS05665	COG4166	transmembrane transport
O23A_RS05670	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
O23A_RS05675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O23A_RS05685	COG4591	ABC-type transport system involved in lipoprotein release permease component
O23A_RS05690	COG1136	(ABC) transporter
O23A_RS05695	COG4591	ABC-type transport system involved in lipoprotein release permease component
O23A_RS05700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
O23A_RS05715	COG0544	peptidyl-prolyl cis-trans isomerase activity
O23A_RS05720	COG0740	serine-type endopeptidase activity
O23A_RS05725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O23A_RS05730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O23A_RS05735	COG0776	regulation of translation
O23A_RS05740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O23A_RS05745	COG0488	(ABC) transporter
O23A_RS05750	COG0582	viral genome integration into host DNA
O23A_RS05815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O23A_RS05820	COG3162	membrane
O23A_RS05835	COG1250	3-hydroxyacyl-CoA dehydrogenase
O23A_RS05835	COG1024	Enoyl-CoA hydratase
O23A_RS05840	COG1115	amino acid carrier protein
O23A_RS05855	COG1584	GPR1 FUN34 yaaH family protein
O23A_RS05885	COG1024	Enoyl-CoA hydratase
O23A_RS05890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O23A_RS05895	COG1960	acyl-CoA dehydrogenase activity
O23A_RS05905	COG1960	acyl-CoA dehydrogenase activity
O23A_RS05910	COG1024	Enoyl-CoA hydratase
O23A_RS05915	COG1024	Enoyl-CoA hydratase
O23A_RS05925	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS05935	COG0730	response to heat
O23A_RS05985	COG2823	Periplasmic or secreted lipoprotein
O23A_RS05990	COG2203	Gaf domain
O23A_RS05990	COG5001	Diguanylate cyclase
O23A_RS05990	COG4251	negative regulation of phosphorylation
O23A_RS05990	COG3706	GGDEF domain
O23A_RS05995	COG1172	Belongs to the binding-protein-dependent transport system permease family
O23A_RS06000	COG1172	Belongs to the binding-protein-dependent transport system permease family
O23A_RS06005	COG1129	ABC transporter
O23A_RS06010	COG1879	ABC-type sugar transport system periplasmic component
O23A_RS06015	COG0583	DNA-binding transcription factor activity
O23A_RS06020	COG2723	6-phospho-beta-galactosidase activity
O23A_RS06030	COG0583	DNA-binding transcription factor activity
O23A_RS06035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O23A_RS06040	COG0673	inositol 2-dehydrogenase activity
O23A_RS06045	COG0583	DNA-binding transcription factor activity
O23A_RS06055	COG1560	Kdo2-lipid A biosynthetic process
O23A_RS06060	COG1560	Kdo2-lipid A biosynthetic process
O23A_RS06075	COG2199	diguanylate cyclase activity
O23A_RS06075	COG2203	Gaf domain
O23A_RS06085	COG0417	DNA replication proofreading
O23A_RS06120	COG0534	Mate efflux family protein
O23A_RS06130	COG0307	riboflavin synthase, alpha
O23A_RS06140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O23A_RS06145	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
O23A_RS06150	COG0697	spore germination
O23A_RS06155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O23A_RS06195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O23A_RS06200	COG3099	Belongs to the UPF0263 family
O23A_RS06205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
O23A_RS06210	COG2894	cell division
O23A_RS06215	COG0850	regulation of cytokinetic process
O23A_RS06220	COG3100	YcgL domain-containing protein
O23A_RS06225	COG2951	lytic endotransglycosylase activity
O23A_RS06230	COG1760	l-serine dehydratase
O23A_RS06240	COG1760	l-serine dehydratase
O23A_RS06245	COG3123	guanosine phosphorylase activity
O23A_RS06265	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O23A_RS06270	COG2067	long-chain fatty acid transport protein
O23A_RS06275	COG2067	long-chain fatty acid transport protein
O23A_RS06315	COG0714	Associated with various cellular activities
O23A_RS06320	COG0183	Belongs to the thiolase family
O23A_RS06325	COG1024	Enoyl-CoA hydratase
O23A_RS06325	COG1250	3-hydroxyacyl-CoA dehydrogenase
O23A_RS06330	COG2824	Alkylphosphonate utilization operon protein PhnA
O23A_RS06360	COG3706	GGDEF domain
O23A_RS06365	COG2840	Smr protein MutS2
O23A_RS06370	COG2890	protein-(glutamine-N5) methyltransferase activity
O23A_RS06375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O23A_RS06385	COG0513	Belongs to the DEAD box helicase family
O23A_RS06390	COG5654	RES domain protein
O23A_RS06400	COG0814	amino acid
O23A_RS06405	COG1609	Transcriptional regulator
O23A_RS06410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_RS06410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_RS06415	COG1105	Belongs to the carbohydrate kinase PfkB family
O23A_RS06420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_RS06420	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
O23A_RS06420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_RS06425	COG3313	Fe-S protein
O23A_RS06430	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
O23A_RS06435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O23A_RS06440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O23A_RS06445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O23A_RS06455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O23A_RS06475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O23A_RS06480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O23A_RS06485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O23A_RS06490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O23A_RS06495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O23A_RS06500	COG0072	phenylalanine-tRNA ligase activity
O23A_RS06500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O23A_RS06505	COG0776	regulation of translation
O23A_RS06535	COG2199	diguanylate cyclase activity
O23A_RS06540	COG1609	Transcriptional regulator
O23A_RS06545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O23A_RS06550	COG1879	ABC-type sugar transport system periplasmic component
O23A_RS06555	COG1172	Belongs to the binding-protein-dependent transport system permease family
O23A_RS06560	COG1129	ABC transporter
O23A_RS06565	COG1869	D-ribose catabolic process
O23A_RS06570	COG0625	glutathione transferase activity
O23A_RS06585	COG0037	tRNA processing
O23A_RS06590	COG0589	response to stress
O23A_RS06595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O23A_RS06610	COG2217	Heavy metal translocating P-type atpase
O23A_RS06620	COG2010	Cytochrome c
O23A_RS06635	COG3278	Belongs to the heme-copper respiratory oxidase family
O23A_RS06645	COG1956	GAF domain-containing protein
O23A_RS06650	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
O23A_RS06655	COG0793	Belongs to the peptidase S41A family
O23A_RS06660	COG0308	aminopeptidase N
O23A_RS06670	COG2902	Dehydrogenase
O23A_RS06675	COG0167	dihydroorotate dehydrogenase activity
O23A_RS06685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O23A_RS06685	COG0116	Belongs to the methyltransferase superfamily
O23A_RS06695	COG0488	(ABC) transporter
O23A_RS06710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O23A_RS06715	COG1067	ATP-dependent peptidase activity
O23A_RS06790	COG3141	response to X-ray
O23A_RS06800	COG4221	oxidoreductase activity
O23A_RS06845	COG0372	Belongs to the citrate synthase family
O23A_RS06850	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O23A_RS06860	COG2995	paraquat-inducible protein a
O23A_RS06865	COG3008	intermembrane lipid transfer
O23A_RS06870	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
O23A_RS06870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O23A_RS06885	COG0084	hydrolase, TatD family'
O23A_RS06890	COG0470	DNA polymerase III
O23A_RS06895	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O23A_RS06900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O23A_RS06905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O23A_RS06910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O23A_RS06915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O23A_RS06920	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS06930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O23A_RS06935	COG0416	fatty acid biosynthetic process
O23A_RS06940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O23A_RS06945	COG1399	metal-binding, possibly nucleic acid-binding protein
O23A_RS06950	COG0424	maF-like protein
O23A_RS06955	COG0546	phosphoglycolate phosphatase activity
O23A_RS06965	COG1530	ribonuclease E activity
O23A_RS06970	COG0306	phosphate transporter
O23A_RS06975	COG0717	Belongs to the dCTP deaminase family
O23A_RS06980	COG0572	uridine kinase
O23A_RS06985	COG0489	protein tyrosine kinase activity
O23A_RS06990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O23A_RS06990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O23A_RS06995	COG0625	glutathione transferase activity
O23A_RS07000	COG1254	Belongs to the acylphosphatase family
O23A_RS07005	COG0840	transmembrane signaling receptor activity
O23A_RS07010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O23A_RS07025	COG0709	Synthesizes selenophosphate from selenide and ATP
O23A_RS07030	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
O23A_RS07035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O23A_RS07040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O23A_RS07050	COG1643	Atp-dependent helicase
O23A_RS07055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O23A_RS07055	COG0517	IMP dehydrogenase activity
O23A_RS07055	COG0617	tRNA 3'-terminal CCA addition
O23A_RS07060	COG2197	response regulator
O23A_RS07065	COG3314	Sporulation integral membrane protein YlbJ
O23A_RS07070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O23A_RS07075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O23A_RS07080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O23A_RS07085	COG2832	Protein of unknown function (DUF454)
O23A_RS07090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O23A_RS07110	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_RS07115	COG2267	carboxylic ester hydrolase activity
O23A_RS07125	COG1214	PFAM Peptidase M22, glycoprotease
O23A_RS07130	COG1199	ATP-dependent helicase activity
O23A_RS07140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O23A_RS07145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O23A_RS07150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O23A_RS07155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O23A_RS07155	COG0131	Imidazoleglycerol-phosphate dehydratase
O23A_RS07160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O23A_RS07165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O23A_RS07170	COG3437	response regulator, receiver
O23A_RS07175	COG2199	diguanylate cyclase activity
O23A_RS07180	COG2205	protein histidine kinase activity
O23A_RS07180	COG0784	Response regulator, receiver
O23A_RS07180	COG2198	Histidine kinase
O23A_RS07185	COG0107	imidazoleglycerol-phosphate synthase activity
O23A_RS07190	COG0140	phosphoribosyl-ATP diphosphatase activity
O23A_RS07190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O23A_RS07200	COG2378	regulation of single-species biofilm formation
O23A_RS07205	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_RS07210	COG1288	antiporter activity
O23A_RS07220	COG3134	Outer membrane lipoprotein
O23A_RS07235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O23A_RS07255	COG4681	YaeQ
O23A_RS07295	COG0242	peptide deformylase activity
O23A_RS07315	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
O23A_RS07320	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
O23A_RS07330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O23A_RS07335	COG1434	Gram-negative-bacterium-type cell wall biogenesis
O23A_RS07345	COG0205	6-phosphofructokinase activity
O23A_RS07360	COG1473	amidohydrolase
O23A_RS07365	COG1011	Hydrolase
O23A_RS07370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O23A_RS07425	COG3593	DNA synthesis involved in DNA repair
O23A_RS07440	COG0583	DNA-binding transcription factor activity
O23A_RS07445	COG0730	response to heat
O23A_RS07450	COG3148	PFAM DTW domain containing protein
O23A_RS07460	COG1181	Belongs to the D-alanine--D-alanine ligase family
O23A_RS07470	COG0386	Belongs to the glutathione peroxidase family
O23A_RS07475	COG0513	Belongs to the DEAD box helicase family
O23A_RS07490	COG1742	UPF0060 membrane protein
O23A_RS07520	COG2329	Antibiotic biosynthesis monooxygenase
O23A_RS07525	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
O23A_RS07545	COG3243	poly(R)-hydroxyalkanoic acid synthase
O23A_RS07555	COG2501	S4 domain
O23A_RS07565	COG1132	(ABC) transporter
O23A_RS07570	COG1132	(ABC) transporter
O23A_RS07580	COG3118	belongs to the thioredoxin family
O23A_RS07585	COG0471	metal ion transport
O23A_RS07590	COG0058	SHG alpha-glucan phosphorylase activity
O23A_RS07620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O23A_RS07630	COG0814	amino acid
O23A_RS07635	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
O23A_RS07640	COG0514	ATP-dependent DNA helicase (RecQ)
O23A_RS07645	COG2766	serine protein kinase
O23A_RS07655	COG2719	SpoVR family
O23A_RS07665	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O23A_RS07670	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O23A_RS07675	COG0586	Pfam SNARE associated Golgi protein
O23A_RS07685	COG0556	nucleotide-excision repair
O23A_RS07700	COG0569	domain protein
O23A_RS07700	COG2985	domain, Protein
O23A_RS07705	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
O23A_RS07725	COG4565	transcriptional regulatory protein
O23A_RS07730	COG3290	protein histidine kinase activity
O23A_RS07735	COG1940	carbohydrate kinase activity
O23A_RS07735	COG1846	Transcriptional regulator
O23A_RS07740	COG0840	transmembrane signaling receptor activity
O23A_RS07745	COG3012	SEC-C Motif Domain Protein
O23A_RS07750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O23A_RS07755	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
O23A_RS07760	COG0247	lactate metabolic process
O23A_RS07770	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
O23A_RS07775	COG0437	4 iron, 4 sulfur cluster binding
O23A_RS07780	COG3301	Polysulphide reductase, NrfD
O23A_RS07785	COG1138	Cytochrome C-type biogenesis protein
O23A_RS07795	COG4235	cytochrome complex assembly
O23A_RS07795	COG3088	subunit of a heme lyase
O23A_RS07810	COG3033	Beta-eliminating lyase
O23A_RS07820	COG3046	protein related to deoxyribodipyrimidine photolyase
O23A_RS07825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O23A_RS07850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O23A_RS07855	COG0583	DNA-binding transcription factor activity
O23A_RS07865	COG4774	siderophore transport
O23A_RS07870	COG3708	Transcriptional regulator
O23A_RS07870	COG2207	Transcriptional regulator
O23A_RS07880	COG0583	DNA-binding transcription factor activity
O23A_RS07885	COG2910	NAD(P)H-binding
O23A_RS07900	COG0612	Peptidase, M16
O23A_RS07905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O23A_RS07910	COG1944	ATP diphosphatase activity
O23A_RS07915	COG2116	formate transmembrane transporter activity
O23A_RS07920	COG1882	Formate acetyltransferase
O23A_RS07925	COG2983	Belongs to the UPF0260 family
O23A_RS07935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
O23A_RS07940	COG0045	succinate-CoA ligase (ADP-forming) activity
O23A_RS07945	COG0508	dehydrogenase complex catalyzes the overall conversion of
O23A_RS07950	COG0567	Dehydrogenase, E1 component
O23A_RS07960	COG1053	succinate dehydrogenase
O23A_RS07965	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
O23A_RS07990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O23A_RS07995	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
O23A_RS07995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O23A_RS08005	COG3069	C4-dicarboxylate transmembrane transporter activity
O23A_RS08020	COG1451	nucleotide metabolic process
O23A_RS08035	COG0254	rRNA binding
O23A_RS08040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O23A_RS08050	COG1172	Belongs to the binding-protein-dependent transport system permease family
O23A_RS08055	COG1129	ABC transporter
O23A_RS08060	COG1879	ABC-type sugar transport system periplasmic component
O23A_RS08065	COG1069	ribulokinase activity
O23A_RS08075	COG2160	L-arabinose isomerase activity
O23A_RS08080	COG0583	DNA-binding transcription factor activity
O23A_RS08085	COG0436	Aminotransferase
O23A_RS08090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O23A_RS08105	COG2925	Exonuclease
O23A_RS08115	COG3345	alpha-galactosidase
O23A_RS08120	COG1380	Effector of murein hydrolase LrgA
O23A_RS08125	COG1346	cytolysis
O23A_RS08130	COG0295	cytidine deaminase activity
O23A_RS08135	COG1022	Amp-dependent synthetase and ligase
O23A_RS08150	COG0861	Integral membrane protein TerC family
O23A_RS08160	COG2199	diguanylate cyclase activity
O23A_RS08175	COG2154	pterin-4-alpha-carbinolamine dehydratase
O23A_RS08185	COG3768	UPF0283 membrane protein
O23A_RS08190	COG3106	COG3106 Predicted ATPase
O23A_RS08205	COG1842	Phage shock protein A
O23A_RS08210	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O23A_RS08220	COG4168	peptide transport system, permease
O23A_RS08225	COG4171	peptide transport system, permease
O23A_RS08230	COG4172	Belongs to the ABC transporter superfamily
O23A_RS08235	COG4172	Belongs to the ABC transporter superfamily
O23A_RS08245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O23A_RS08250	COG1286	toxin biosynthetic process
O23A_RS08255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O23A_RS08260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O23A_RS08265	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O23A_RS08270	COG0531	amino acid
O23A_RS08270	COG1674	ftsk spoiiie
O23A_RS08280	COG0686	Belongs to the AlaDH PNT family
O23A_RS08285	COG0492	ferredoxin-NADP+ reductase activity
O23A_RS08290	COG3706	GGDEF domain
O23A_RS08295	COG3134	Outer membrane lipoprotein
O23A_RS08300	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
O23A_RS08305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
O23A_RS08310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O23A_RS08315	COG0542	response to heat
O23A_RS08320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O23A_RS08325	COG1278	Cold shock
O23A_RS08330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O23A_RS08385	COG3829	transcription factor binding
O23A_RS08460	COG3501	Rhs element vgr protein
O23A_RS08475	COG0659	secondary active sulfate transmembrane transporter activity
O23A_RS08510	COG0672	)-iron permease
O23A_RS08515	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
O23A_RS08535	COG2814	Major facilitator Superfamily
O23A_RS08550	COG1136	(ABC) transporter
O23A_RS08555	COG0577	efflux transmembrane transporter activity
O23A_RS08600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O23A_RS08605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O23A_RS08605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O23A_RS08610	COG0527	aspartate kinase activity
O23A_RS08620	COG1368	sulfuric ester hydrolase activity
O23A_RS08625	COG1619	proteins homologs of microcin C7 resistance protein MccF
O23A_RS08635	COG0393	Putative heavy-metal-binding
O23A_RS08640	COG1252	NADH dehydrogenase
O23A_RS08645	COG3150	esterase
O23A_RS08660	COG2354	Protein conserved in bacteria
O23A_RS08670	COG0047	phosphoribosylformylglycinamidine synthase activity
O23A_RS08670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O23A_RS08675	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
O23A_RS08680	COG1645	bacterial-type flagellum-dependent swarming motility
O23A_RS08685	COG1160	GTP binding
O23A_RS08690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O23A_RS08695	COG2976	Protein conserved in bacteria
O23A_RS08700	COG0124	histidyl-tRNA synthetase
O23A_RS08710	COG1426	Protein conserved in bacteria
O23A_RS08720	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O23A_RS08725	COG0105	UTP biosynthetic process
O23A_RS08730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O23A_RS08740	COG0633	Ferredoxin
O23A_RS08745	COG0443	Heat shock 70 kDa protein
O23A_RS08750	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O23A_RS08760	COG0822	iron-sulfur transferase activity
O23A_RS08765	COG1104	cysteine desulfurase activity
O23A_RS08785	COG3154	lipid carrier protein
O23A_RS08790	COG0826	peptidase U32
O23A_RS08795	COG0826	peptidase U32
O23A_RS08805	COG2897	thiosulfate sulfurtransferase activity
O23A_RS08810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O23A_RS08815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O23A_RS08820	COG1862	Preprotein translocase
O23A_RS08825	COG0343	queuine tRNA-ribosyltransferase activity
O23A_RS08830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O23A_RS08835	COG0517	IMP dehydrogenase activity
O23A_RS08845	COG3634	alkyl hydroperoxide reductase activity
O23A_RS08860	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O23A_RS08860	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O23A_RS08865	COG0509	glycine decarboxylation via glycine cleavage system
O23A_RS08870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O23A_RS08875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O23A_RS08880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O23A_RS08900	COG0243	molybdopterin cofactor binding
O23A_RS08905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O23A_RS08910	COG0583	DNA-binding transcription factor activity
O23A_RS08915	COG2814	Major facilitator Superfamily
O23A_RS08920	COG0444	Belongs to the ABC transporter superfamily
O23A_RS08925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O23A_RS08930	COG0601	transmembrane transport
O23A_RS08940	COG0625	glutathione transferase activity
O23A_RS08950	COG0483	inositol monophosphate 1-phosphatase activity
O23A_RS08970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O23A_RS08980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O23A_RS09015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O23A_RS09030	COG0301	tRNA thio-modification
O23A_RS09030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O23A_RS09040	COG4953	penicillin-binding protein 1C
O23A_RS09045	COG2373	Large extracellular alpha-helical protein
O23A_RS09050	COG0446	pyridine nucleotide-disulphide oxidoreductase
O23A_RS09060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
O23A_RS09100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O23A_RS09100	COG1215	transferase activity, transferring glycosyl groups
O23A_RS09135	COG2431	L-lysine efflux transmembrane transporter activity
O23A_RS09140	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
O23A_RS09150	COG1393	Belongs to the ArsC family
O23A_RS09160	COG4783	chaperone-mediated protein folding
O23A_RS09165	COG0425	Belongs to the sulfur carrier protein TusA family
O23A_RS09170	COG0628	permease
O23A_RS09185	COG3842	ATPase activity
O23A_RS09190	COG3833	ABC-type maltose transport systems, permease component
O23A_RS09195	COG1175	transmembrane transport
O23A_RS09200	COG2182	Extracellular solute-binding protein
O23A_RS09205	COG3081	Nucleoid-associated protein
O23A_RS09210	COG3082	Protein of unknown function (DUF1414)
O23A_RS09215	COG3083	sulfuric ester hydrolase activity
O23A_RS09220	COG4771	TonB-dependent receptor
O23A_RS09225	COG1770	oligopeptidase
O23A_RS09245	COG4574	serine-type endopeptidase inhibitor activity
O23A_RS09250	COG3085	chromosome segregation
O23A_RS09255	COG0583	DNA-binding transcription factor activity
O23A_RS09260	COG1605	Chorismate mutase
O23A_RS09260	COG0287	Prephenate dehydrogenase
O23A_RS09265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O23A_RS09270	COG0584	glycerophosphoryl diester phosphodiesterase
O23A_RS09275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O23A_RS09285	COG1349	DNA-binding transcription factor activity
O23A_RS09290	COG2271	Major facilitator Superfamily
O23A_RS09295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O23A_RS09300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O23A_RS09305	COG0583	DNA-binding transcription factor activity
O23A_RS09320	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
O23A_RS09325	COG0656	L-ascorbic acid biosynthetic process
O23A_RS09330	COG2814	Major facilitator Superfamily
O23A_RS09345	COG3220	belongs to the UPF0276 family
O23A_RS09365	COG1294	oxidase, subunit
O23A_RS09375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O23A_RS09385	COG2979	Protein of unknown function (DUF533)
O23A_RS09405	COG0583	DNA-binding transcription factor activity
O23A_RS09415	COG2807	transmembrane transport
O23A_RS09420	COG1187	pseudouridine synthase activity
O23A_RS09425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O23A_RS09435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
O23A_RS09450	COG1403	HNH endonuclease
O23A_RS09470	COG1166	arginine decarboxylase activity
O23A_RS09480	COG2195	Cleaves the N-terminal amino acid of tripeptides
O23A_RS09505	COG2353	YceI-like domain
O23A_RS09510	COG0583	DNA-binding transcription factor activity
O23A_RS09520	COG2759	Belongs to the formate--tetrahydrofolate ligase family
O23A_RS09525	COG0840	transmembrane signaling receptor activity
O23A_RS09530	COG0302	gtp cyclohydrolase
O23A_RS09535	COG0303	'Molybdopterin
O23A_RS09540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O23A_RS09545	COG0596	Alpha beta hydrolase
O23A_RS09550	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
O23A_RS09565	COG0314	molybdopterin synthase activity
O23A_RS09570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O23A_RS09575	COG0315	cyclic pyranopterin monophosphate synthase activity
O23A_RS09580	COG0521	Mo-molybdopterin cofactor biosynthetic process
O23A_RS09585	COG3005	denitrification pathway
O23A_RS09595	COG0348	domain, Protein
O23A_RS09600	COG0437	4 iron, 4 sulfur cluster binding
O23A_RS09605	COG0243	molybdopterin cofactor binding
O23A_RS09615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O23A_RS09620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O23A_RS09625	COG3850	Histidine kinase
O23A_RS09630	COG2197	response regulator
O23A_RS09660	COG0121	glutamine amidotransferase
O23A_RS09665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O23A_RS09670	COG1960	acyl-CoA dehydrogenase activity
O23A_RS09675	COG0784	Response regulator, receiver
O23A_RS09675	COG3437	response regulator, receiver
O23A_RS09690	COG0328	RNA-DNA hybrid ribonuclease activity
O23A_RS09695	COG2226	methyltransferase
O23A_RS09700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O23A_RS09705	COG1388	LysM domain
O23A_RS09705	COG0741	lytic transglycosylase activity
O23A_RS09710	COG3021	interspecies interaction between organisms
O23A_RS09720	COG1607	acyl-coa hydrolase
O23A_RS09745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O23A_RS09765	COG2911	Protein conserved in bacteria
O23A_RS09770	COG0729	surface antigen
O23A_RS09790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O23A_RS09795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O23A_RS09805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O23A_RS09815	COG4134	Bacterial extracellular solute-binding protein
O23A_RS09820	COG4135	transport system, permease component
O23A_RS09825	COG4136	ATPase activity
O23A_RS09830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O23A_RS09835	COG2951	lytic endotransglycosylase activity
O23A_RS09840	COG1846	Transcriptional regulator
O23A_RS09850	COG0033	Phosphoglucomutase
O23A_RS09855	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
O23A_RS09860	COG0596	Alpha beta hydrolase
O23A_RS09875	COG0716	FMN binding
O23A_RS09885	COG0735	belongs to the Fur family
O23A_RS09890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O23A_RS09900	COG2190	(PTS) system
O23A_RS09900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O23A_RS09900	COG1263	PTS System
O23A_RS09905	COG0363	glucosamine-6-phosphate deaminase activity
O23A_RS09910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O23A_RS09915	COG1940	carbohydrate kinase activity
O23A_RS09915	COG1846	Transcriptional regulator
O23A_RS09925	COG0217	transcriptional regulatory protein
O23A_RS09930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O23A_RS09935	COG1801	Protein of unknown function DUF72
O23A_RS09940	COG4106	trans-aconitate 2-methyltransferase activity
O23A_RS09945	COG0500	methyltransferase
O23A_RS09965	COG0450	alkyl hydroperoxide reductase
O23A_RS09970	COG0583	DNA-binding transcription factor activity
O23A_RS09980	COG0791	NLP P60 protein
O23A_RS09995	COG1309	transcriptional regulator
O23A_RS10035	COG0534	Mate efflux family protein
O23A_RS10045	COG2841	Protein conserved in bacteria
O23A_RS10050	COG0674	pyruvate-flavodoxin oxidoreductase activity
O23A_RS10050	COG1013	pyruvate-flavodoxin oxidoreductase activity
O23A_RS10050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
O23A_RS10050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
O23A_RS10060	COG3217	Mosc domain protein beta barrel domain protein
O23A_RS10060	COG3217	Mosc domain protein beta barrel domain protein
O23A_RS10060	COG0633	Ferredoxin
O23A_RS10060	COG0633	Ferredoxin
O23A_RS10070	COG0501	Belongs to the peptidase M48B family
O23A_RS10075	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
O23A_RS10080	COG2226	methyltransferase
O23A_RS10080	COG1073	alpha beta
O23A_RS10085	COG0156	8-amino-7-oxononanoate synthase activity
O23A_RS10090	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O23A_RS10110	COG0017	Asparaginyl-tRNA synthetase
O23A_RS10115	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
O23A_RS10130	COG0583	DNA-binding transcription factor activity
O23A_RS10135	COG1393	Belongs to the ArsC family
O23A_RS10140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O23A_RS10145	COG1876	peptidase activity
O23A_RS10155	COG3263	regulation of cellular component size
O23A_RS10165	COG3263	regulation of cellular component size
O23A_RS10175	COG1280	lysine exporter protein (LysE YggA)
O23A_RS10180	COG0840	transmembrane signaling receptor activity
O23A_RS10200	COG1957	nucleoside hydrolase
O23A_RS10205	COG0564	pseudouridine synthase activity
O23A_RS10215	COG1454	alcohol dehydrogenase
O23A_RS10255	COG2894	cell division
O23A_RS10265	COG4964	Belongs to the GSP D family
O23A_RS10295	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O23A_RS10300	COG0702	epimerase
O23A_RS10305	COG2914	Belongs to the UPF0125 (RnfH) family
O23A_RS10310	COG2867	negative regulation of translational initiation
O23A_RS10315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O23A_RS10340	COG0210	DNA helicase
O23A_RS10385	COG1595	DNA-templated transcription, initiation
O23A_RS10395	COG3220	belongs to the UPF0276 family
O23A_RS10415	COG2199	diguanylate cyclase activity
O23A_RS10415	COG2203	Gaf domain
O23A_RS10420	COG0589	response to stress
O23A_RS10425	COG0659	secondary active sulfate transmembrane transporter activity
O23A_RS10430	COG5642	Protein of unknown function (DUF2384)
O23A_RS10445	COG2916	Histone family protein nucleoid-structuring protein H-NS
O23A_RS10585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O23A_RS10630	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O23A_RS10655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O23A_RS10665	COG0538	isocitrate dehydrogenase activity
O23A_RS10670	COG2207	Transcriptional regulator
O23A_RS10675	COG1482	cell wall glycoprotein biosynthetic process
O23A_RS10685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O23A_RS10690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
O23A_RS10695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O23A_RS10695	COG1263	PTS System
O23A_RS10700	COG1609	Transcriptional regulator
O23A_RS10720	COG2814	Major facilitator Superfamily
O23A_RS10725	COG0109	protoheme IX farnesyltransferase activity
O23A_RS10735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O23A_RS10740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O23A_RS10795	COG0708	Exodeoxyribonuclease III
O23A_RS10820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_RS10825	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_RS10835	COG0095	Lipoate-protein ligase
O23A_RS10880	COG1285	pathogenesis
O23A_RS10910	COG0484	heat shock protein binding
O23A_RS10915	COG0443	Heat shock 70 kDa protein
O23A_RS10920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O23A_RS10925	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O23A_RS10930	COG0497	DNA recombination
O23A_RS10935	COG1227	inorganic diphosphatase activity
O23A_RS10945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_RS10950	COG1136	(ABC) transporter
O23A_RS10950	COG0577	efflux transmembrane transporter activity
O23A_RS10955	COG1538	Outer membrane efflux protein
O23A_RS10960	COG2375	cellular response to nickel ion
O23A_RS10965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O23A_RS10975	COG2916	Histone family protein nucleoid-structuring protein H-NS
O23A_RS11005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O23A_RS11010	COG1917	Cupin 2, conserved barrel domain protein
O23A_RS11010	COG1396	sequence-specific DNA binding
O23A_RS11025	COG0531	amino acid
O23A_RS11035	COG0531	amino acid
O23A_RS11040	COG1283	sodium-dependent phosphate transmembrane transporter activity
O23A_RS11050	COG3384	dioxygenase
O23A_RS11065	COG0813	purine-nucleoside phosphorylase activity
O23A_RS11085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O23A_RS11090	COG0083	homoserine kinase activity
O23A_RS11100	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
O23A_RS11105	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
O23A_RS11120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O23A_RS11130	COG0745	RESPONSE REGULATOR receiver
O23A_RS11145	COG4988	ABC transporter
O23A_RS11150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O23A_RS11170	COG1720	tRNA m6t6A37 methyltransferase activity
O23A_RS11190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O23A_RS11195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_RS11205	COG2190	(PTS) system
O23A_RS11220	COG3038	cytochrome b561
O23A_RS11230	COG0419	ATPase involved in DNA repair
O23A_RS11235	COG0420	3'-5' exonuclease activity
O23A_RS11245	COG2974	May be involved in recombination
O23A_RS11250	COG0405	Gamma-glutamyltransferase
O23A_RS11255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O23A_RS11255	COG4651	solute:proton antiporter activity
O23A_RS11270	COG0469	pyruvate kinase activity
O23A_RS11275	COG1196	nuclear chromosome segregation
O23A_RS11275	COG3264	Mechanosensitive ion channel
O23A_RS11295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_RS11315	COG0281	malic enzyme
O23A_RS11330	COG0437	4 iron, 4 sulfur cluster binding
O23A_RS11335	COG3383	formate dehydrogenase (NAD+) activity
O23A_RS11335	COG3383	formate dehydrogenase (NAD+) activity
O23A_RS11370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O23A_RS11380	COG3852	Histidine kinase
O23A_RS11395	COG4662	Binding-protein-dependent transport system inner membrane component
O23A_RS11405	COG0746	molybdenum cofactor guanylyltransferase activity
O23A_RS11410	COG0303	'Molybdopterin
O23A_RS11415	COG1289	transmembrane transporter activity
O23A_RS11420	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O23A_RS11455	COG0784	Response regulator, receiver
O23A_RS11455	COG2205	protein histidine kinase activity
O23A_RS11470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O23A_RS11480	COG4608	Belongs to the ABC transporter superfamily
O23A_RS11490	COG2971	BadF BadG BcrA BcrD
O23A_RS11500	COG0840	transmembrane signaling receptor activity
O23A_RS11515	COG3724	N-succinylarginine dihydrolase activity
O23A_RS11520	COG0616	signal peptide processing
O23A_RS11525	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS11530	COG0583	DNA-binding transcription factor activity
O23A_RS11540	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
O23A_RS11550	COG0583	DNA-binding transcription factor activity
O23A_RS11555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O23A_RS11560	COG1881	PFAM PEBP family protein
O23A_RS11570	COG0366	Alpha amylase catalytic
O23A_RS11620	COG0037	tRNA processing
O23A_RS11625	COG3590	peptidase
O23A_RS11635	COG0488	(ABC) transporter
O23A_RS11645	COG0531	amino acid
O23A_RS11650	COG0814	amino acid
O23A_RS11665	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
O23A_RS11670	COG1982	Orn Lys Arg decarboxylase major
O23A_RS11675	COG0531	amino acid
O23A_RS11680	COG3710	Transcriptional regulator
O23A_RS11685	COG0825	malonyl-CoA metabolic process
O23A_RS11695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O23A_RS11700	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O23A_RS11705	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O23A_RS11710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O23A_RS11715	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O23A_RS11730	COG0750	zinc metalloprotease
O23A_RS11735	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O23A_RS11740	COG0575	Belongs to the CDS family
O23A_RS11745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O23A_RS11750	COG0233	cytoplasmic translational termination
O23A_RS11755	COG0528	UMP kinase activity
O23A_RS11760	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O23A_RS11765	COG0052	Belongs to the universal ribosomal protein uS2 family
O23A_RS11770	COG0024	Methionine aminopeptidase
O23A_RS11775	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
O23A_RS11780	COG2171	N-acyltransferase activity
O23A_RS11790	COG1263	PTS System
O23A_RS11790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O23A_RS11800	COG4580	involved in the transport of maltose and maltodextrins
O23A_RS11810	COG0564	pseudouridine synthase activity
O23A_RS11815	COG3098	single-species biofilm formation
O23A_RS11840	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
O23A_RS11850	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O23A_RS11850	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O23A_RS11865	COG1611	Belongs to the LOG family
O23A_RS11870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O23A_RS11875	COG0473	3-isopropylmalate dehydrogenase activity
O23A_RS11885	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
O23A_RS11890	COG2363	Small membrane protein
O23A_RS11900	COG0583	DNA-binding transcription factor activity
O23A_RS11905	COG0840	transmembrane signaling receptor activity
O23A_RS11910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O23A_RS11925	COG1477	protein flavinylation
O23A_RS11930	COG2871	sodium ion transport
O23A_RS11935	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O23A_RS11940	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O23A_RS11945	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O23A_RS11950	COG1805	sodium ion transport
O23A_RS11955	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O23A_RS11960	COG0271	Belongs to the BolA IbaG family
O23A_RS11965	COG2813	Specifically methylates the guanine in position
O23A_RS11975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O23A_RS11985	COG2211	Major facilitator Superfamily
O23A_RS11990	COG3248	Nucleoside-binding outer membrane protein
O23A_RS11995	COG1666	GTP binding
O23A_RS12000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O23A_RS12025	COG3459	Glycosyltransferase 36 associated
O23A_RS12050	COG4104	PAAR repeat-containing protein
O23A_RS12070	COG2771	luxR family
O23A_RS12085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O23A_RS12085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O23A_RS12090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O23A_RS12100	COG1151	hydroxylamine reductase activity
O23A_RS12105	COG0783	Belongs to the Dps family
O23A_RS12130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O23A_RS12145	COG0300	oxidoreductase activity
O23A_RS12155	COG0415	Belongs to the DNA photolyase family
O23A_RS12160	COG0789	Transcriptional regulator
O23A_RS12165	COG3272	Protein of unknown function (DUF1722)
O23A_RS12195	COG1605	Chorismate mutase
O23A_RS12195	COG0077	Prephenate dehydratase
O23A_RS12220	COG2133	pyrroloquinoline quinone binding
O23A_RS12230	COG1349	DNA-binding transcription factor activity
O23A_RS12235	COG2084	Dehydrogenase
O23A_RS12245	COG0235	Class ii aldolase
O23A_RS12250	COG3622	Belongs to the hyi family
O23A_RS12255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O23A_RS12260	COG2610	gluconate transmembrane transporter activity
O23A_RS12270	COG5278	phosphoserine phosphatase activity
O23A_RS12270	COG0840	transmembrane signaling receptor activity
O23A_RS12280	COG0300	oxidoreductase activity
O23A_RS12305	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O23A_RS12320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O23A_RS12330	COG3813	Protein conserved in bacteria
O23A_RS12340	COG0826	peptidase U32
O23A_RS12345	COG1280	lysine exporter protein (LysE YggA)
O23A_RS12355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O23A_RS12360	COG0840	transmembrane signaling receptor activity
O23A_RS12365	COG0745	RESPONSE REGULATOR receiver
O23A_RS12375	COG0643	Histidine kinase
O23A_RS12375	COG2198	Histidine kinase
O23A_RS12385	COG0835	chemotaxis
O23A_RS12390	COG0840	transmembrane signaling receptor activity
O23A_RS12400	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
O23A_RS12405	COG2201	protein-glutamate methylesterase activity
O23A_RS12410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O23A_RS12440	COG2197	response regulator
O23A_RS12445	COG3188	usher protein
O23A_RS12460	COG2200	EAL domain
O23A_RS12460	COG2203	Gaf domain
O23A_RS12460	COG2199	diguanylate cyclase activity
O23A_RS12535	COG0589	response to stress
O23A_RS12540	COG0659	secondary active sulfate transmembrane transporter activity
O23A_RS12555	COG0456	acetyltransferase
O23A_RS12565	COG1309	transcriptional regulator
O23A_RS12580	COG1136	(ABC) transporter
O23A_RS12595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O23A_RS12640	COG1538	Outer membrane efflux protein
O23A_RS12645	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_RS12660	COG0745	RESPONSE REGULATOR receiver
O23A_RS12665	COG5002	protein histidine kinase activity
O23A_RS12685	COG2132	Multicopper oxidase
O23A_RS12695	COG0456	acetyltransferase
O23A_RS12710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O23A_RS12715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O23A_RS12730	COG0826	peptidase U32
O23A_RS12735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O23A_RS12740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O23A_RS12770	COG0737	Belongs to the 5'-nucleotidase family
O23A_RS12790	COG2204	response regulator
O23A_RS12795	COG0545	Peptidyl-prolyl cis-trans isomerase
O23A_RS12810	COG1047	Peptidyl-prolyl cis-trans
O23A_RS12815	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
O23A_RS12825	COG0784	Response regulator, receiver
O23A_RS12825	COG0835	chemotaxis
O23A_RS12830	COG0429	hydrolase of the alpha beta-hydrolase fold
O23A_RS12835	COG2203	Gaf domain
O23A_RS12835	COG5001	Diguanylate cyclase
O23A_RS12835	COG4251	negative regulation of phosphorylation
O23A_RS12835	COG3706	GGDEF domain
O23A_RS12840	COG3089	Belongs to the UPF0270 family
O23A_RS12850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O23A_RS12855	COG0463	Glycosyl transferase, family 2
O23A_RS12860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O23A_RS12860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O23A_RS12865	COG0726	polysaccharide deacetylase
O23A_RS12870	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O23A_RS12875	COG2076	Multidrug Resistance protein
O23A_RS12880	COG2076	Multidrug Resistance protein
O23A_RS12885	COG3954	Phosphoribulokinase
O23A_RS12900	COG1765	OsmC-like protein
O23A_RS12910	COG2226	methyltransferase
O23A_RS12915	COG3397	chitin binding
O23A_RS12930	COG2205	protein histidine kinase activity
O23A_RS12930	COG2202	Pas domain
O23A_RS12940	COG3655	Transcriptional regulator
O23A_RS12950	COG2814	Major facilitator Superfamily
O23A_RS12960	COG4771	TonB-dependent receptor
O23A_RS12980	COG0748	coenzyme F420 binding
O23A_RS12985	COG3721	Heme iron utilization protein
O23A_RS12995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O23A_RS13020	COG0741	lytic transglycosylase activity
O23A_RS13025	COG0488	(ABC) transporter
O23A_RS13035	COG2252	PERMEase
O23A_RS13040	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O23A_RS13045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O23A_RS13050	COG3178	'Phosphotransferase
O23A_RS13055	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
O23A_RS13065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
O23A_RS13070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O23A_RS13075	COG2967	ApaG domain
O23A_RS13080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O23A_RS13095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O23A_RS13105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O23A_RS13115	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_RS13120	COG3314	Sporulation integral membrane protein YlbJ
O23A_RS13125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O23A_RS13130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O23A_RS13135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O23A_RS13140	COG0142	geranyltranstransferase activity
O23A_RS13145	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
O23A_RS13150	COG0330	HflC and HflK could
O23A_RS13155	COG0330	HflC and HflK could
O23A_RS13160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O23A_RS13165	COG1923	regulation of RNA biosynthetic process
O23A_RS13170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O23A_RS13175	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O23A_RS13185	COG0802	atpase or kinase
O23A_RS13190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O23A_RS13190	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
O23A_RS13215	COG2011	ABC-type metal ion transport system permease component
O23A_RS13220	COG1464	Belongs to the NlpA lipoprotein family
O23A_RS13230	COG0840	transmembrane signaling receptor activity
O23A_RS13255	COG0784	Response regulator, receiver
O23A_RS13255	COG2198	Histidine kinase
O23A_RS13255	COG5002	protein histidine kinase activity
O23A_RS13290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O23A_RS13295	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
O23A_RS13305	COG2716	regulation of RNA biosynthetic process
O23A_RS13310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O23A_RS13315	COG3013	Belongs to the UPF0304 family
O23A_RS13325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O23A_RS13330	COG0857	belongs to the CobB CobQ family
O23A_RS13330	COG0280	phosphate acetyltransferase
O23A_RS13335	COG0440	acetolactate synthase activity
O23A_RS13340	COG0028	Belongs to the TPP enzyme family
O23A_RS13355	COG0671	phosphoesterase, PA-phosphatase related
O23A_RS13365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O23A_RS13370	COG0473	3-isopropylmalate dehydrogenase activity
O23A_RS13375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O23A_RS13380	COG0066	3-isopropylmalate dehydratase activity
O23A_RS13395	COG4143	(ABC) transporter
O23A_RS13400	COG1178	ABC-type Fe3 transport system permease component
O23A_RS13405	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
O23A_RS13410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O23A_RS13420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O23A_RS13450	COG0316	Belongs to the HesB IscA family
O23A_RS13460	COG0038	chloride channel
O23A_RS13465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O23A_RS13480	COG0671	phosphoesterase, PA-phosphatase related
O23A_RS13490	COG0784	Response regulator, receiver
O23A_RS13490	COG3437	response regulator, receiver
O23A_RS13495	COG0583	DNA-binding transcription factor activity
O23A_RS13500	COG2076	Multidrug Resistance protein
O23A_RS13510	COG0346	lactoylglutathione lyase activity
O23A_RS13515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O23A_RS13520	COG1643	Atp-dependent helicase
O23A_RS13530	COG1489	DNA binding
O23A_RS13535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O23A_RS13540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O23A_RS13545	COG0617	tRNA 3'-terminal CCA addition
O23A_RS13550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O23A_RS13555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O23A_RS13560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O23A_RS13570	COG0842	Transport permease protein
O23A_RS13575	COG1131	(ABC) transporter
O23A_RS13590	COG0163	prenyltransferase activity
O23A_RS13595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O23A_RS13600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
O23A_RS13605	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O23A_RS13610	COG2816	NAD+ diphosphatase activity
O23A_RS13620	COG4991	sh3 domain protein
O23A_RS13625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O23A_RS13645	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O23A_RS13650	COG1640	4-alpha-glucanotransferase
O23A_RS13655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O23A_RS13660	COG0676	glucose-6-phosphate 1-epimerase activity
O23A_RS13665	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O23A_RS13670	COG0840	transmembrane signaling receptor activity
O23A_RS13715	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
O23A_RS13720	COG2885	chlorophyll binding
O23A_RS13725	COG0823	Involved in the tonB-independent uptake of proteins
O23A_RS13740	COG0811	peptide transport
O23A_RS13745	COG0824	Thioesterase
O23A_RS13750	COG3790	cyd operon protein YbgE
O23A_RS13755	COG4890	Cyd operon protein YbgT
O23A_RS13760	COG1294	oxidase, subunit
O23A_RS13765	COG1271	oxidase subunit
O23A_RS13770	COG2255	four-way junction helicase activity
O23A_RS13775	COG0632	four-way junction helicase activity
O23A_RS13780	COG0840	transmembrane signaling receptor activity
O23A_RS13785	COG0442	prolyl-tRNA aminoacylation
O23A_RS13795	COG1902	pentaerythritol trinitrate reductase activity
O23A_RS13805	COG0456	acetyltransferase
O23A_RS13815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
O23A_RS13830	COG5001	Diguanylate cyclase
O23A_RS13830	COG3300	MHYT domain
O23A_RS13850	COG0714	Associated with various cellular activities
O23A_RS13860	COG0456	acetyltransferase
O23A_RS13870	COG1022	Amp-dependent synthetase and ligase
O23A_RS13880	COG2918	glutathione biosynthetic process
O23A_RS13885	COG0612	Peptidase, M16
O23A_RS13890	COG1238	metal cluster binding
O23A_RS13895	COG1064	alcohol dehydrogenase
O23A_RS13925	COG0359	binds to the 23S rRNA
O23A_RS13930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O23A_RS13935	COG0360	Binds together with S18 to 16S ribosomal RNA
O23A_RS13940	COG1914	H( )-stimulated, divalent metal cation uptake system
O23A_RS13945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O23A_RS13960	COG2153	protein acetylation
O23A_RS13970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O23A_RS13975	COG0557	exoribonuclease II activity
O23A_RS13980	COG3706	GGDEF domain
O23A_RS13985	COG1854	S-ribosylhomocysteine lyase activity
O23A_RS14000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O23A_RS14000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O23A_RS14040	COG2207	Transcriptional regulator
O23A_RS14055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O23A_RS14060	COG1047	Peptidyl-prolyl cis-trans
O23A_RS14065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O23A_RS14070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O23A_RS14075	COG0196	riboflavin kinase activity
O23A_RS14080	COG0728	peptidoglycan biosynthetic process
O23A_RS14085	COG0268	Binds directly to 16S ribosomal RNA
O23A_RS14090	COG0640	Transcriptional regulator
O23A_RS14095	COG0583	DNA-binding transcription factor activity
O23A_RS14105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O23A_RS14110	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O23A_RS14165	COG5642	Protein of unknown function (DUF2384)
O23A_RS14170	COG0659	secondary active sulfate transmembrane transporter activity
O23A_RS14175	COG0589	response to stress
O23A_RS14205	COG1393	Belongs to the ArsC family
O23A_RS14210	COG0798	PFAM Bile acid sodium symporter
O23A_RS14220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O23A_RS14230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O23A_RS14245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O23A_RS14250	COG0640	Transcriptional regulator
O23A_RS14270	COG0437	4 iron, 4 sulfur cluster binding
O23A_RS14275	COG0243	molybdopterin cofactor binding
O23A_RS14280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O23A_RS14300	COG4974	Belongs to the 'phage' integrase family
O23A_RS14305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O23A_RS14310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O23A_RS14320	COG1051	belongs to the nudix hydrolase family
O23A_RS14325	COG3066	DNA modification
O23A_RS14335	COG0335	large ribosomal subunit rRNA binding
O23A_RS14340	COG0336	Belongs to the RNA methyltransferase TrmD family
O23A_RS14345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O23A_RS14350	COG0228	four-way junction DNA binding
O23A_RS14355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O23A_RS14360	COG4137	Cytochrome C assembly protein
O23A_RS14365	COG4536	flavin adenine dinucleotide binding
O23A_RS14370	COG1959	2 iron, 2 sulfur cluster binding
O23A_RS14375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O23A_RS14375	COG1017	nitric oxide dioxygenase activity
O23A_RS14380	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
O23A_RS14385	COG0039	L-malate dehydrogenase activity
O23A_RS14390	COG4160	amino acid transport
O23A_RS14395	COG4215	(ABC) transporter
O23A_RS14400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_RS14405	COG1126	abc transporter atp-binding protein
O23A_RS14410	COG1438	arginine binding
O23A_RS14415	COG2837	iron assimilation
O23A_RS14420	COG3842	ATPase activity
O23A_RS14430	COG1840	ABC-type Fe3 transport system, periplasmic component
O23A_RS14435	COG0347	Belongs to the P(II) protein family
O23A_RS14450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O23A_RS14470	COG1929	Belongs to the glycerate kinase type-1 family
O23A_RS14475	COG2610	gluconate transmembrane transporter activity
O23A_RS14480	COG3835	regulator
O23A_RS14485	COG3112	Uncharacterised protein family (UPF0231)
O23A_RS14500	COG0840	transmembrane signaling receptor activity
O23A_RS14520	COG0513	Belongs to the DEAD box helicase family
O23A_RS14560	COG1448	Aminotransferase
O23A_RS14575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
O23A_RS14580	COG1328	CTP reductase activity
O23A_RS14600	COG0793	Belongs to the peptidase S41A family
O23A_RS14600	COG4946	Tricorn protease homolog
O23A_RS14615	COG1215	transferase activity, transferring glycosyl groups
O23A_RS14620	COG0726	polysaccharide deacetylase
O23A_RS14620	COG1649	PFAM Uncharacterised BCR, COG1649
O23A_RS14660	COG3397	chitin binding
O23A_RS14665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_RS14670	COG1126	abc transporter atp-binding protein
O23A_RS14680	COG0765	amino acid transport
O23A_RS14685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O23A_RS14690	COG0583	DNA-binding transcription factor activity
O23A_RS14695	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
O23A_RS14700	COG4208	sulfate ABC transporter
O23A_RS14705	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
O23A_RS14715	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
O23A_RS14720	COG3174	membrane
O23A_RS14725	COG0110	maltose O-acetyltransferase activity
O23A_RS14755	COG1942	4-Oxalocrotonate Tautomerase
O23A_RS14765	COG0583	DNA-binding transcription factor activity
O23A_RS14770	COG0165	Argininosuccinate lyase
O23A_RS14775	COG0137	argininosuccinate synthase activity
O23A_RS14785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O23A_RS14790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O23A_RS14800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
O23A_RS14810	COG2072	flavoprotein involved in K transport
O23A_RS14815	COG1393	Belongs to the ArsC family
O23A_RS14820	COG0798	PFAM Bile acid sodium symporter
O23A_RS14835	COG0640	Transcriptional regulator
O23A_RS14840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O23A_RS14860	COG3068	Protein conserved in bacteria
O23A_RS14870	COG0739	heme binding
O23A_RS14890	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
O23A_RS14895	COG1121	(ABC) transporter
O23A_RS14900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O23A_RS14905	COG0583	DNA-binding transcription factor activity
O23A_RS14915	COG1573	uracil-dna glycosylase
O23A_RS14920	COG2962	Rard protein
O23A_RS14930	COG2827	Endonuclease containing a URI domain
O23A_RS14945	COG1842	Phage shock protein A
O23A_RS14950	COG0204	Acyl-transferase
O23A_RS14970	COG3118	belongs to the thioredoxin family
O23A_RS14975	COG2259	Doxx family
O23A_RS15025	COG0583	DNA-binding transcription factor activity
O23A_RS15050	COG1051	belongs to the nudix hydrolase family
O23A_RS15055	COG3150	esterase
O23A_RS15065	COG3151	Protein conserved in bacteria
O23A_RS15070	COG0494	nUDIX hydrolase
O23A_RS15075	COG1538	Outer membrane efflux protein
O23A_RS15080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
O23A_RS15080	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
O23A_RS15085	COG1560	Kdo2-lipid A biosynthetic process
O23A_RS15100	COG1392	Phosphate transport regulator
O23A_RS15105	COG0306	phosphate transporter
O23A_RS15110	COG0617	tRNA 3'-terminal CCA addition
O23A_RS15115	COG3267	Type II secretory pathway component ExeA
O23A_RS15115	COG3409	Peptidoglycan-binding domain 1 protein
O23A_RS15125	COG1194	a g-specific adenine glycosylase
O23A_RS15130	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
O23A_RS15140	COG3111	PFAM Bacterial OB fold (BOF) protein
O23A_RS15145	COG3240	lipase activity
O23A_RS15160	COG3009	Protein conserved in bacteria
O23A_RS15165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O23A_RS15165	COG3008	intermembrane lipid transfer
O23A_RS15170	COG2995	paraquat-inducible protein a
O23A_RS15180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O23A_RS15190	COG4251	negative regulation of phosphorylation
O23A_RS15190	COG2203	Gaf domain
O23A_RS15190	COG3706	GGDEF domain
O23A_RS15190	COG5001	Diguanylate cyclase
O23A_RS15195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O23A_RS15200	COG2813	Specifically methylates the guanine in position
O23A_RS15205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O23A_RS15210	COG0297	glycogen (starch) synthase activity
O23A_RS15250	COG1757	Na H antiporter
O23A_RS15260	COG0110	maltose O-acetyltransferase activity
O23A_RS15265	COG0366	Alpha amylase catalytic
O23A_RS15270	COG1263	PTS System
O23A_RS15270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O23A_RS15275	COG1609	Transcriptional regulator
O23A_RS15285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O23A_RS15290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O23A_RS15295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O23A_RS15295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O23A_RS15300	COG2723	6-phospho-beta-galactosidase activity
O23A_RS15305	COG1447	Phosphotransferase system cellobiose-specific component IIA
O23A_RS15310	COG1940	carbohydrate kinase activity
O23A_RS15320	COG1609	Transcriptional regulator
O23A_RS15330	COG0252	asparaginase activity
O23A_RS15345	COG1803	Methylglyoxal synthase
O23A_RS15370	COG1444	tRNA N-acetyltransferase activity
O23A_RS15375	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS15380	COG0784	Response regulator, receiver
O23A_RS15380	COG0835	chemotaxis
O23A_RS15390	COG3314	Sporulation integral membrane protein YlbJ
O23A_RS15430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O23A_RS15435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O23A_RS15450	COG0477	Major facilitator Superfamily
O23A_RS15455	COG0523	cobalamin synthesis protein
O23A_RS15465	COG1280	lysine exporter protein (LysE YggA)
O23A_RS15480	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS15485	COG2200	EAL domain
O23A_RS15490	COG1049	propionate catabolic process, 2-methylcitrate cycle
O23A_RS15500	COG0840	transmembrane signaling receptor activity
O23A_RS15505	COG0840	transmembrane signaling receptor activity
O23A_RS15515	COG5002	protein histidine kinase activity
O23A_RS15515	COG3447	MASE1 domain protein
O23A_RS15515	COG5001	Diguanylate cyclase
O23A_RS15520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O23A_RS15525	COG0508	dehydrogenase complex catalyzes the overall conversion of
O23A_RS15530	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
O23A_RS15535	COG2186	Transcriptional regulator
O23A_RS15560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O23A_RS15565	COG1459	type II secretion system
O23A_RS15570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O23A_RS15580	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
O23A_RS15585	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
O23A_RS15590	COG0494	nUDIX hydrolase
O23A_RS15600	COG0653	protein targeting
O23A_RS15610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
O23A_RS15615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O23A_RS15620	COG0849	cell division
O23A_RS15625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O23A_RS15630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O23A_RS15635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O23A_RS15640	COG0772	Belongs to the SEDS family
O23A_RS15645	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O23A_RS15650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O23A_RS15655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O23A_RS15665	COG0768	penicillin binding
O23A_RS15670	COG3116	cell division
O23A_RS15675	COG0275	rRNA processing
O23A_RS15680	COG2001	Belongs to the MraZ family
O23A_RS15690	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O23A_RS15695	COG3107	peptidoglycan biosynthetic process
O23A_RS15700	COG0792	nuclease activity
O23A_RS15705	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O23A_RS15710	COG2823	Periplasmic or secreted lipoprotein
O23A_RS15715	COG2969	positive regulation of protein catabolic process
O23A_RS15720	COG0625	glutathione transferase activity
O23A_RS15725	COG2857	Cytochrome c1
O23A_RS15730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O23A_RS15735	COG0723	plastoquinol--plastocyanin reductase activity
O23A_RS15740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O23A_RS15745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O23A_RS15750	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O23A_RS15760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O23A_RS15765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O23A_RS15800	COG3964	amidohydrolase
O23A_RS15820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_RS15825	COG1660	Displays ATPase and GTPase activities
O23A_RS15830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_RS15840	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
O23A_RS15845	COG1137	ATPase activity
O23A_RS15850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
O23A_RS15855	COG3117	lipopolysaccharide transmembrane transporter activity
O23A_RS15860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
O23A_RS15865	COG0517	IMP dehydrogenase activity
O23A_RS15865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O23A_RS15870	COG1127	ABC transporter
O23A_RS15875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O23A_RS15880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O23A_RS15885	COG2854	intermembrane phospholipid transfer
O23A_RS15895	COG5007	Belongs to the BolA IbaG family
O23A_RS15900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O23A_RS15905	COG0312	modulator of DNA gyrase
O23A_RS15910	COG3028	Belongs to the UPF0307 family
O23A_RS15920	COG2926	Belongs to the UPF0265 family
O23A_RS15955	COG1396	sequence-specific DNA binding
O23A_RS15960	COG3135	benzoate transporter
O23A_RS15990	COG3047	cAMP biosynthetic process
O23A_RS15995	COG2199	diguanylate cyclase activity
O23A_RS16000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O23A_RS16005	COG2197	response regulator
O23A_RS16035	COG1278	Cold shock
O23A_RS16040	COG4771	TonB-dependent receptor
O23A_RS16045	COG3706	GGDEF domain
O23A_RS16090	COG0347	Belongs to the P(II) protein family
O23A_RS16095	COG0004	ammonium transporteR
O23A_RS16110	COG0346	lactoylglutathione lyase activity
O23A_RS16125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O23A_RS16130	COG1074	ATP-dependent DNA helicase activity
O23A_RS16135	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
O23A_RS16140	COG2259	Doxx family
O23A_RS16145	COG1741	Belongs to the pirin family
O23A_RS16155	COG0583	DNA-binding transcription factor activity
O23A_RS16180	COG1176	ABC-type spermidine putrescine transport system, permease component I
O23A_RS16190	COG3842	ATPase activity
O23A_RS16200	COG2199	diguanylate cyclase activity
O23A_RS16200	COG2203	Gaf domain
O23A_RS16220	COG1247	-acetyltransferase
O23A_RS16225	COG0753	catalase activity
O23A_RS16250	COG0494	nUDIX hydrolase
O23A_RS16255	COG0628	permease
O23A_RS16260	COG3284	Transcriptional regulator
O23A_RS16270	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
O23A_RS16270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_RS16270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O23A_RS16275	COG1461	Dihydroxyacetone kinase
O23A_RS16280	COG2376	Dihydroxyacetone kinase
O23A_RS16285	COG2252	PERMEase
O23A_RS16325	COG0203	ribosomal protein L17
O23A_RS16330	COG0202	RNA polymerase activity
O23A_RS16335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O23A_RS16340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O23A_RS16345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O23A_RS16350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O23A_RS16355	COG0201	protein transport
O23A_RS16360	COG0200	Binds to the 23S rRNA
O23A_RS16365	COG1841	ribosomal large subunit assembly
O23A_RS16370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O23A_RS16375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O23A_RS16380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O23A_RS16385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O23A_RS16390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O23A_RS16395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O23A_RS16400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O23A_RS16405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O23A_RS16410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O23A_RS16415	COG0255	Belongs to the universal ribosomal protein uL29 family
O23A_RS16420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O23A_RS16425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O23A_RS16430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O23A_RS16435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O23A_RS16440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O23A_RS16445	COG0089	rRNA binding
O23A_RS16450	COG0088	Forms part of the polypeptide exit tunnel
O23A_RS16455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O23A_RS16460	COG0051	transcription antitermination factor activity, RNA binding
O23A_RS16480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O23A_RS16485	COG2183	response to ionizing radiation
O23A_RS16505	COG0596	Alpha beta hydrolase
O23A_RS16510	COG1040	competence protein
O23A_RS16515	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
O23A_RS16515	COG0316	Belongs to the HesB IscA family
O23A_RS16520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O23A_RS16525	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
O23A_RS16530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O23A_RS16535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O23A_RS16540	COG4942	peptidase
O23A_RS16550	COG1609	Transcriptional regulator
O23A_RS16555	COG0800	Aldolase
O23A_RS16560	COG0129	dihydroxy-acid dehydratase activity
O23A_RS16565	COG3265	gluconokinase activity
O23A_RS16570	COG2610	gluconate transmembrane transporter activity
O23A_RS16575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O23A_RS16580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O23A_RS16590	COG0456	acetyltransferase
O23A_RS16595	COG4106	trans-aconitate 2-methyltransferase activity
O23A_RS16600	COG1490	D-aminoacyl-tRNA deacylase activity
O23A_RS16605	COG1295	ribonuclease BN
O23A_RS16610	COG1217	gtp-binding protein TYPA
O23A_RS16615	COG0174	glutamine synthetase
O23A_RS16625	COG3852	Histidine kinase
O23A_RS16630	COG2204	response regulator
O23A_RS16635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O23A_RS16640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O23A_RS16650	COG3078	GTPase activator activity
O23A_RS16660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O23A_RS16675	COG0456	acetyltransferase
O23A_RS16685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O23A_RS16690	COG0408	coproporphyrinogen oxidase activity
O23A_RS16695	COG0009	L-threonylcarbamoyladenylate synthase
O23A_RS16705	COG0551	DNA topoisomerase type I activity
O23A_RS16710	COG2922	Belongs to the Smg family
O23A_RS16715	COG0758	DNA mediated transformation
O23A_RS16720	COG1652	LysM domain
O23A_RS16725	COG0242	peptide deformylase activity
O23A_RS16730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O23A_RS16735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O23A_RS16735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O23A_RS16740	COG0569	domain protein
O23A_RS16745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O23A_RS16770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O23A_RS16775	COG0686	Belongs to the AlaDH PNT family
O23A_RS16780	COG0519	Catalyzes the synthesis of GMP from XMP
O23A_RS16780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O23A_RS16790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O23A_RS16800	COG1012	belongs to the aldehyde dehydrogenase family
O23A_RS16810	COG2962	Rard protein
O23A_RS16820	COG1280	lysine exporter protein (LysE YggA)
O23A_RS16830	COG2391	methyltransferase activity
O23A_RS16845	COG1280	lysine exporter protein (LysE YggA)
O23A_RS16870	COG2823	Periplasmic or secreted lipoprotein
O23A_RS16900	COG1943	Transposase
O23A_RS16905	COG0210	DNA helicase
O23A_RS16910	COG1744	ABC transporter substrate-binding protein PnrA-like
O23A_RS16915	COG3845	ABC transporter
O23A_RS16920	COG4603	Belongs to the binding-protein-dependent transport system permease family
O23A_RS16925	COG1079	Belongs to the binding-protein-dependent transport system permease family
O23A_RS16930	COG0583	DNA-binding transcription factor activity
O23A_RS16950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O23A_RS16955	COG0385	Bile acid
O23A_RS16960	COG1609	Transcriptional regulator
O23A_RS17000	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O23A_RS17015	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
O23A_RS17020	COG3074	FtsZ-dependent cytokinesis
O23A_RS17030	COG1045	serine acetyltransferase
O23A_RS17040	COG0745	RESPONSE REGULATOR receiver
O23A_RS17045	COG2205	protein histidine kinase activity
O23A_RS17050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O23A_RS17055	COG0534	Mate efflux family protein
O23A_RS17070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O23A_RS17075	COG2937	Belongs to the GPAT DAPAT family
O23A_RS17080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
O23A_RS17085	COG3161	chorismate lyase activity
O23A_RS17090	COG1580	Controls the rotational direction of flagella during chemotaxis
O23A_RS17110	COG0604	alcohol dehydrogenase
O23A_RS17115	COG1609	Transcriptional regulator
O23A_RS17120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_RS17135	COG1519	Transferase
O23A_RS17140	COG0859	PFAM glycosyl transferase family 9
O23A_RS17145	COG0463	Glycosyl transferase, family 2
O23A_RS17150	COG0859	PFAM glycosyl transferase family 9
O23A_RS17155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O23A_RS17160	COG2990	Protein conserved in bacteria
O23A_RS17165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O23A_RS17175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O23A_RS17180	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O23A_RS17185	COG2003	Belongs to the UPF0758 family
O23A_RS17190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O23A_RS17195	COG0756	dUTP diphosphatase activity
O23A_RS17200	COG1309	transcriptional regulator
O23A_RS17205	COG0668	transmembrane transport
O23A_RS17215	COG0166	Belongs to the GPI family
O23A_RS17220	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O23A_RS17225	COG0583	DNA-binding transcription factor activity
O23A_RS17240	COG1042	CoA-binding domain protein
O23A_RS17240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_RS17240	COG0045	succinate-CoA ligase (ADP-forming) activity
O23A_RS17275	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O23A_RS17280	COG4206	TonB-dependent receptor
O23A_RS17285	COG0583	DNA-binding transcription factor activity
O23A_RS17300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O23A_RS17305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O23A_RS17310	COG2223	nitrite transmembrane transporter activity
O23A_RS17315	COG3279	Response regulator of the LytR AlgR family
O23A_RS17320	COG3275	phosphorelay sensor kinase activity
O23A_RS17325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_RS17325	COG2205	protein histidine kinase activity
O23A_RS17335	COG2197	response regulator
O23A_RS17340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_RS17340	COG2205	protein histidine kinase activity
O23A_RS17360	COG3539	Fimbrial protein
O23A_RS17375	COG3121	Chaperone
O23A_RS17380	COG3188	usher protein
O23A_RS17405	COG2081	HI0933 family
O23A_RS17410	COG1528	Iron-storage protein
O23A_RS17415	COG3706	GGDEF domain
O23A_RS17420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O23A_RS17425	COG0589	response to stress
O23A_RS17465	COG3642	lipopolysaccharide core region biosynthetic process
O23A_RS17470	COG0859	PFAM glycosyl transferase family 9
O23A_RS17480	COG0194	GDP metabolic process
O23A_RS17485	COG1758	RNA polymerase activity
O23A_RS17490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O23A_RS17495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O23A_RS17500	COG2267	carboxylic ester hydrolase activity
O23A_RS17505	COG0561	phosphatase activity
O23A_RS17535	COG1309	transcriptional regulator
O23A_RS17540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_RS17545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O23A_RS17550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_RS17550	COG4191	Histidine kinase
O23A_RS17555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O23A_RS17580	COG2205	protein histidine kinase activity
O23A_RS17585	COG0745	RESPONSE REGULATOR receiver
O23A_RS17590	COG2814	Major facilitator Superfamily
O23A_RS17605	COG3977	Valine--pyruvate aminotransferase
O23A_RS17610	COG0071	Belongs to the small heat shock protein (HSP20) family
O23A_RS17615	COG0071	Belongs to the small heat shock protein (HSP20) family
O23A_RS17620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O23A_RS17630	COG2378	regulation of single-species biofilm formation
O23A_RS17655	COG0592	DNA-directed DNA polymerase activity
O23A_RS17660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O23A_RS17675	COG1126	abc transporter atp-binding protein
O23A_RS17680	COG0230	Belongs to the bacterial ribosomal protein bL34 family
O23A_RS17685	COG0594	ribonuclease P activity
O23A_RS17690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O23A_RS17695	COG0706	membrane insertase activity
O23A_RS17700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O23A_RS17715	COG3433	isochorismatase activity
O23A_RS17715	COG2226	methyltransferase
O23A_RS17715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O23A_RS17725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O23A_RS17735	COG1132	(ABC) transporter
O23A_RS17735	COG2375	cellular response to nickel ion
O23A_RS17740	COG1132	(ABC) transporter
O23A_RS17745	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O23A_RS17750	COG4605	iron ion homeostasis
O23A_RS17755	COG4604	ABC transporter, ATP-binding protein
O23A_RS17760	COG4607	ABC-type enterochelin transport system periplasmic component
O23A_RS17765	COG4774	siderophore transport
O23A_RS17775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O23A_RS17780	COG1120	ATPase activity
O23A_RS17785	COG4615	Cyclic peptide transporter
O23A_RS17790	COG4774	siderophore transport
O23A_RS17795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O23A_RS17800	COG0445	tRNA wobble uridine modification
O23A_RS17805	COG0357	Ribosomal RNA small subunit methyltransferase G
O23A_RS17810	COG1192	Involved in chromosome partitioning
O23A_RS17815	COG1475	DNA binding
O23A_RS17820	COG3312	ion transport
O23A_RS17825	COG0356	it plays a direct role in the translocation of protons across the membrane
O23A_RS17835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O23A_RS17840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O23A_RS17845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O23A_RS17850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O23A_RS17855	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O23A_RS17860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O23A_RS17865	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O23A_RS17870	COG4452	Inner membrane protein CreD
O23A_RS17880	COG2205	protein histidine kinase activity
O23A_RS17885	COG0745	RESPONSE REGULATOR receiver
O23A_RS17890	COG1349	DNA-binding transcription factor activity
O23A_RS17895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O23A_RS17900	COG2771	luxR family
O23A_RS17910	COG0811	peptide transport
O23A_RS17915	COG0811	peptide transport
O23A_RS17920	COG0848	biopolymer transport protein
O23A_RS17925	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
O23A_RS17960	COG0402	S-adenosylhomocysteine deaminase activity
O23A_RS17965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O23A_RS17975	COG3165	ubiquinone biosynthetic process from chorismate
O23A_RS17980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O23A_RS17990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O23A_RS17995	COG0805	protein transport
O23A_RS18000	COG0084	hydrolase, TatD family'
O23A_RS18020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O23A_RS18025	COG0742	ribosomal rna small subunit methyltransferase
O23A_RS18035	COG0248	Ppx GppA phosphatase
O23A_RS18040	COG0513	Belongs to the DEAD box helicase family
O23A_RS18045	COG3118	belongs to the thioredoxin family
O23A_RS18060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
O23A_RS18085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O23A_RS18125	COG1609	Transcriptional regulator
O23A_RS18140	COG2188	Transcriptional regulator
O23A_RS18145	COG3604	Transcriptional regulator
O23A_RS18150	COG1773	rubredoxin
O23A_RS18150	COG0426	domain, Protein
O23A_RS18155	COG0446	pyridine nucleotide-disulphide oxidoreductase
O23A_RS18165	COG0348	domain, Protein
O23A_RS18170	COG0814	amino acid
O23A_RS18180	COG0640	Transcriptional regulator
O23A_RS18195	COG2202	Pas domain
O23A_RS18195	COG2199	diguanylate cyclase activity
O23A_RS18195	COG2200	EAL domain
O23A_RS18205	COG0529	Catalyzes the synthesis of activated sulfate
O23A_RS18210	COG0751	glycine-tRNA ligase activity
O23A_RS18215	COG0752	glycyl-tRNA synthetase alpha subunit
O23A_RS18220	COG2818	Glycosylase
O23A_RS18225	COG2885	chlorophyll binding
O23A_RS18230	COG0251	oxidation-reduction process
O23A_RS18235	COG0425	Belongs to the sulfur carrier protein TusA family
O23A_RS18240	COG0425	Belongs to the sulfur carrier protein TusA family
O23A_RS18265	COG0183	Belongs to the thiolase family
O23A_RS18270	COG1250	3-hydroxyacyl-CoA dehydrogenase
O23A_RS18270	COG1024	Enoyl-CoA hydratase
O23A_RS18275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O23A_RS18280	COG0006	proline dipeptidase activity
O23A_RS18285	COG1739	Uncharacterized protein family UPF0029
O23A_RS18290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O23A_RS18295	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
O23A_RS18325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O23A_RS18330	COG2166	iron-sulfur cluster assembly
O23A_RS18335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O23A_RS18340	COG0210	DNA helicase
O23A_RS18355	COG1063	alcohol dehydrogenase
O23A_RS18370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O23A_RS18375	COG0438	transferase activity, transferring glycosyl groups
O23A_RS18395	COG0859	PFAM glycosyl transferase family 9
O23A_RS18405	COG1561	YicC-like family, N-terminal region
O23A_RS18415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O23A_RS18430	COG3706	GGDEF domain
O23A_RS18430	COG2203	Gaf domain
O23A_RS18430	COG5001	Diguanylate cyclase
O23A_RS18430	COG4251	negative regulation of phosphorylation
O23A_RS18435	COG3084	Protein conserved in bacteria
O23A_RS18445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O23A_RS18450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O23A_RS18455	COG3639	organic phosphonate transmembrane transporter activity
O23A_RS18460	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
O23A_RS18465	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
O23A_RS18475	COG1335	isochorismatase
O23A_RS18490	COG0204	Acyl-transferase
O23A_RS18495	COG0606	chelatase, subunit chli
O23A_RS18500	COG1404	Belongs to the peptidase S8 family
O23A_RS18505	COG0464	growth
O23A_RS18565	COG0210	DNA helicase
O23A_RS18575	COG0606	chelatase, subunit chli
O23A_RS18585	COG3978	acetolactate synthase activity
O23A_RS18595	COG0129	dihydroxy-acid dehydratase activity
O23A_RS18615	COG1309	transcriptional regulator
O23A_RS18625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O23A_RS18630	COG0254	rRNA binding
O23A_RS18635	COG0702	epimerase
O23A_RS18640	COG0281	malic enzyme
O23A_RS18650	COG2205	protein histidine kinase activity
O23A_RS18660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O23A_RS18690	COG4310	Domain of unknown function (DUF2172)
O23A_RS18710	COG2089	acid synthase
O23A_RS18720	COG1083	cytidylyl-transferase
O23A_RS18740	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_RS18755	COG1215	transferase activity, transferring glycosyl groups
O23A_RS18770	COG1216	Glycosyl transferase, family 2
O23A_RS18790	COG0529	Catalyzes the synthesis of activated sulfate
O23A_RS18800	COG0574	Belongs to the PEP-utilizing enzyme family
O23A_RS18800	COG3848	Pyruvate phosphate dikinase
O23A_RS18805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O23A_RS18810	COG1213	nucleotidyl transferase
O23A_RS18815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O23A_RS18820	COG1086	Polysaccharide biosynthesis protein
O23A_RS18825	COG0366	Alpha amylase catalytic
O23A_RS18840	COG0443	Heat shock 70 kDa protein
O23A_RS18845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O23A_RS18850	COG3045	CreA protein
O23A_RS18865	COG0174	glutamine synthetase
O23A_RS18885	COG3842	ATPase activity
O23A_RS18890	COG1176	ABC-type spermidine putrescine transport system, permease component I
O23A_RS18895	COG1177	transmembrane transport
O23A_RS18900	COG2258	MOSC domain
O23A_RS18920	COG2050	protein possibly involved in aromatic compounds catabolism
O23A_RS18925	COG0514	ATP-dependent DNA helicase (RecQ)
O23A_RS18935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
O23A_RS18945	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
O23A_RS18950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O23A_RS18960	COG2239	Acts as a magnesium transporter
O23A_RS18965	COG1648	precorrin-2 dehydrogenase activity
O23A_RS18965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O23A_RS18970	COG2116	formate transmembrane transporter activity
O23A_RS18980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O23A_RS18990	COG0477	Major facilitator Superfamily
O23A_RS18995	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O23A_RS19000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O23A_RS19010	COG0018	arginyl-trna synthetase
O23A_RS19020	COG1595	DNA-templated transcription, initiation
O23A_RS19030	COG1968	undecaprenyl-diphosphatase activity
O23A_RS19035	COG0667	Aldo Keto reductase
O23A_RS19040	COG2017	converts alpha-aldose to the beta-anomer
O23A_RS19045	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O23A_RS19055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O23A_RS19060	COG1609	Transcriptional regulator
O23A_RS19065	COG3250	beta-galactosidase activity
O23A_RS19080	COG4211	Belongs to the binding-protein-dependent transport system permease family
O23A_RS19110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O23A_RS19115	COG1288	antiporter activity
O23A_RS19120	COG1438	arginine binding
O23A_RS19125	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
O23A_RS19130	COG0540	Belongs to the ATCase OTCase family
O23A_RS19145	COG0688	phosphatidylethanolamine metabolic process
O23A_RS19155	COG3040	lipid binding
O23A_RS19160	COG2207	Transcriptional regulator
O23A_RS19165	COG1979	alcohol dehydrogenase
O23A_RS19170	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
O23A_RS19175	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
O23A_RS19185	COG2964	Protein conserved in bacteria
O23A_RS19190	COG3681	Belongs to the UPF0597 family
O23A_RS19200	COG0446	pyridine nucleotide-disulphide oxidoreductase
O23A_RS19205	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O23A_RS19210	COG0564	pseudouridine synthase activity
O23A_RS19220	COG0542	response to heat
O23A_RS19225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O23A_RS19230	COG2502	aspartate--ammonia ligase
O23A_RS19235	COG1522	sequence-specific DNA binding
O23A_RS19245	COG5413	integral membrane protein
O23A_RS19250	COG0517	IMP dehydrogenase activity
O23A_RS19250	COG0617	tRNA 3'-terminal CCA addition
O23A_RS19250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O23A_RS19255	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS19265	COG2205	protein histidine kinase activity
O23A_RS19275	COG2204	response regulator
O23A_RS19290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O23A_RS19295	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
O23A_RS19325	COG0243	molybdopterin cofactor binding
O23A_RS19330	COG3005	denitrification pathway
O23A_RS19335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O23A_RS19340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O23A_RS19345	COG0569	domain protein
O23A_RS19350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O23A_RS19375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O23A_RS19390	COG0250	Participates in transcription elongation, termination and antitermination
O23A_RS19395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O23A_RS19400	COG0081	regulation of translation
O23A_RS19405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O23A_RS19410	COG0222	ribosome binding
O23A_RS19415	COG0085	RNA polymerase activity
O23A_RS19420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O23A_RS19425	COG2964	Protein conserved in bacteria
O23A_RS19440	COG2923	Belongs to the DsrF TusC family
O23A_RS19445	COG2168	tRNA wobble position uridine thiolation
O23A_RS19450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O23A_RS19455	COG0049	tRNA binding
O23A_RS19460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O23A_RS19465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O23A_RS19470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O23A_RS19530	COG2249	NAD(P)H dehydrogenase (quinone) activity
O23A_RS19545	COG1770	oligopeptidase
O23A_RS19565	COG3714	YhhN family
O23A_RS19590	COG1301	dicarboxylic acid transport
O23A_RS19600	COG2095	MarC family integral membrane protein
O23A_RS19610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O23A_RS19620	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
O23A_RS19625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O23A_RS19650	COG0742	ribosomal rna small subunit methyltransferase
O23A_RS19655	COG0552	protein localization to endoplasmic reticulum
O23A_RS19660	COG2884	Cell division ATP-binding protein ftsE
O23A_RS19665	COG2177	Part of the ABC transporter FtsEX involved in
O23A_RS19675	COG0288	reversible hydration of carbon dioxide
O23A_RS19680	COG2188	Transcriptional regulator
O23A_RS19685	COG1228	amidohydrolase
O23A_RS19690	COG0010	Belongs to the arginase family
O23A_RS19695	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O23A_RS19700	COG2986	histidine ammonia-lyase
O23A_RS19705	COG0387	Pfam Sodium calcium exchanger
O23A_RS19715	COG2199	diguanylate cyclase activity
O23A_RS19715	COG2200	EAL domain
O23A_RS19760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O23A_RS19765	COG1459	type II secretion system
O23A_RS19780	COG2165	general secretion pathway protein
O23A_RS19785	COG4968	Prepilin-type N-terminal cleavage methylation domain
O23A_RS19810	COG1077	Cell shape determining protein MreB Mrl
O23A_RS19815	COG1792	Involved in formation and maintenance of cell shape
O23A_RS19820	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
O23A_RS19825	COG0424	maF-like protein
O23A_RS19830	COG1530	ribonuclease E activity
O23A_RS19835	COG3164	Protein of unknown function
O23A_RS19845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O23A_RS19850	COG0312	modulator of DNA gyrase
O23A_RS19865	COG0477	Major facilitator Superfamily
O23A_RS19875	COG3437	response regulator, receiver
O23A_RS19880	COG0784	Response regulator, receiver
O23A_RS19880	COG2205	protein histidine kinase activity
O23A_RS19880	COG5002	protein histidine kinase activity
O23A_RS19885	COG2172	sigma factor antagonist activity
O23A_RS19890	COG1366	Belongs to the anti-sigma-factor antagonist family
O23A_RS19900	COG3700	Belongs to the class B bacterial acid phosphatase family
O23A_RS19910	COG1639	'signal transduction protein
O23A_RS19935	COG0189	ligase activity
O23A_RS19940	COG0642	Histidine kinase
O23A_RS19945	COG0745	RESPONSE REGULATOR receiver
O23A_RS19965	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O23A_RS19970	COG0352	thiamine-phosphate diphosphorylase activity
O23A_RS19975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O23A_RS19985	COG2022	thiamine diphosphate biosynthetic process
O23A_RS19990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O23A_RS20000	COG2131	deaminase
O23A_RS20010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_RS20015	COG0110	maltose O-acetyltransferase activity
O23A_RS20020	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
O23A_RS20035	COG0814	amino acid
O23A_RS20040	COG3932	Exopolysaccharide synthesis, ExoD
O23A_RS20055	COG1733	regulation of RNA biosynthetic process
O23A_RS20095	COG1494	fructose-1,6-bisphosphatase
O23A_RS20110	COG2959	enzyme of heme biosynthesis
O23A_RS20120	COG0181	hydroxymethylbilane synthase activity
O23A_RS20125	COG3072	Adenylate cyclase
O23A_RS20130	COG0400	carboxylic ester hydrolase activity
O23A_RS20135	COG1965	Belongs to the frataxin family
O23A_RS20140	COG0019	diaminopimelate decarboxylase activity
O23A_RS20145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O23A_RS20160	COG1011	Hydrolase
O23A_RS20170	COG0668	transmembrane transport
O23A_RS20180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O23A_RS20185	COG0561	phosphatase activity
O23A_RS20200	COG0842	Transport permease protein
O23A_RS20200	COG1129	ABC transporter
O23A_RS20210	COG1058	Belongs to the CinA family
O23A_RS20210	COG1546	Belongs to the CinA family
O23A_RS20215	COG1418	mRNA catabolic process
O23A_RS20220	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
O23A_RS20230	COG1522	sequence-specific DNA binding
O23A_RS20235	COG1368	sulfuric ester hydrolase activity
O23A_RS20255	COG1285	pathogenesis
O23A_RS20275	COG4221	oxidoreductase activity
O23A_RS20295	COG1979	alcohol dehydrogenase
O23A_RS20305	COG2873	o-acetylhomoserine
O23A_RS20320	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O23A_RS20335	COG5380	lipid catabolic process
O23A_RS20340	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
O23A_RS20350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O23A_RS20355	COG2949	membrane
O23A_RS20360	COG3291	Pkd domain containing protein
O23A_RS20370	COG3539	Fimbrial protein
O23A_RS20380	COG3188	usher protein
O23A_RS20385	COG3121	Chaperone
O23A_RS20390	COG3539	Fimbrial protein
O23A_RS20405	COG0318	PFAM AMP-dependent synthetase and ligase
O23A_RS20415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
O23A_RS20420	COG0596	Alpha beta hydrolase
O23A_RS20425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O23A_RS20430	COG1169	isochorismate synthase
O23A_RS20435	COG1575	Belongs to the MenA family. Type 1 subfamily
O23A_RS20460	COG0513	Belongs to the DEAD box helicase family
O23A_RS20465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O23A_RS20470	COG1988	membrane-bound metal-dependent
O23A_RS20485	COG1671	Belongs to the UPF0178 family
O23A_RS20505	COG0484	heat shock protein binding
O23A_RS20510	COG3263	regulation of cellular component size
O23A_RS20515	COG3722	fumarate hydratase activity
O23A_RS20520	COG0246	Mannitol dehydrogenase
O23A_RS20525	COG2213	PTS system mannitol-specific
O23A_RS20525	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O23A_RS20540	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
O23A_RS20555	COG2771	luxR family
O23A_RS20570	COG3133	Outer membrane lipoprotein
O23A_RS20575	COG0456	acetyltransferase
O23A_RS20595	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
O23A_RS20600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O23A_RS20620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O23A_RS20625	COG1459	type II secretion system
O23A_RS20630	COG2165	general secretion pathway protein
O23A_RS20640	COG2165	general secretion pathway protein
O23A_RS20645	COG4795	General secretion pathway protein
O23A_RS20650	COG3156	type II secretion system protein K
O23A_RS20660	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
O23A_RS20675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O23A_RS20680	COG1011	Hydrolase
O23A_RS20685	COG0494	nUDIX hydrolase
O23A_RS20690	COG1218	3'(2'),5'-bisphosphate nucleotidase
O23A_RS20695	COG0814	amino acid
O23A_RS20700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O23A_RS20715	COG0626	cystathionine gamma-synthase activity
O23A_RS20720	COG0460	homoserine dehydrogenase
O23A_RS20720	COG0527	aspartate kinase activity
O23A_RS20735	COG1346	cytolysis
O23A_RS20740	COG1380	Effector of murein hydrolase LrgA
O23A_RS20745	COG0583	DNA-binding transcription factor activity
O23A_RS20780	COG1546	Belongs to the CinA family
O23A_RS20785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O23A_RS20795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O23A_RS20800	COG0527	aspartate kinase activity
O23A_RS20805	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O23A_RS20840	COG1686	Belongs to the peptidase S11 family
O23A_RS20845	COG0586	Pfam SNARE associated Golgi protein
O23A_RS20850	COG1253	flavin adenine dinucleotide binding
O23A_RS20860	COG2927	DNA polymerase III (CHI subunit)
O23A_RS20865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O23A_RS20870	COG0795	lipopolysaccharide-transporting ATPase activity
O23A_RS20875	COG0795	lipopolysaccharide-transporting ATPase activity
O23A_RS20890	COG0004	ammonium transporteR
O23A_RS20895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O23A_RS20910	COG2165	general secretion pathway protein
O23A_RS20915	COG0084	hydrolase, TatD family'
O23A_RS20920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O23A_RS20930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O23A_RS20935	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
O23A_RS20940	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
O23A_RS20945	COG0813	purine-nucleoside phosphorylase activity
O23A_RS20955	COG0560	Phosphoserine phosphatase
O23A_RS20980	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
O23A_RS20985	COG0776	regulation of translation
O23A_RS21000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O23A_RS21005	COG0735	belongs to the Fur family
O23A_RS21025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O23A_RS21030	COG0513	Belongs to the DEAD box helicase family
O23A_RS21035	COG3022	response to hydroperoxide
O23A_RS21050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O23A_RS21055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O23A_RS21060	COG0762	integral membrane protein
O23A_RS21065	COG1872	DUF167
O23A_RS21080	COG4166	transmembrane transport
O23A_RS21090	COG0110	maltose O-acetyltransferase activity
O23A_RS21100	COG1024	Enoyl-CoA hydratase
O23A_RS21115	COG4221	oxidoreductase activity
O23A_RS21125	COG2957	Belongs to the agmatine deiminase family
O23A_RS21130	COG0154	amidase activity
O23A_RS21155	COG0513	Belongs to the DEAD box helicase family
O23A_RS21175	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
O23A_RS21245	COG2205	protein histidine kinase activity
O23A_RS21250	COG0745	RESPONSE REGULATOR receiver
O23A_RS21255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_RS21260	COG1136	(ABC) transporter
O23A_RS21260	COG0577	efflux transmembrane transporter activity
O23A_RS21265	COG1505	serine-type exopeptidase activity
O23A_RS21270	COG2982	Protein involved in outer membrane biogenesis
O23A_RS21280	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS21290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O23A_RS21295	COG3730	PTS system glucitol sorbitol-specific
O23A_RS21310	COG1028	Short-chain dehydrogenase reductase Sdr
O23A_RS21320	COG1349	DNA-binding transcription factor activity
O23A_RS21325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O23A_RS21345	COG2130	NADP-dependent
O23A_RS21350	COG1764	response to oxidative stress
O23A_RS21355	COG1846	Transcriptional regulator
O23A_RS21385	COG0561	phosphatase activity
O23A_RS21400	COG0733	neurotransmitter:sodium symporter activity
O23A_RS21410	COG0733	neurotransmitter:sodium symporter activity
O23A_RS21435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O23A_RS21450	COG1794	racemase activity, acting on amino acids and derivatives
O23A_RS21460	COG2731	YhcH YjgK YiaL family protein
O23A_RS21470	COG0668	transmembrane transport
O23A_RS21475	COG1376	ErfK ybiS ycfS ynhG family protein
O23A_RS21480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O23A_RS21490	COG0789	Transcriptional regulator
O23A_RS21525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
O23A_RS21535	COG0488	(ABC) transporter
O23A_RS21540	COG0517	IMP dehydrogenase activity
O23A_RS21540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O23A_RS21545	COG1585	Membrane protein implicated in regulation of membrane protease activity
O23A_RS21550	COG0330	HflC and HflK could
O23A_RS21555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O23A_RS21555	COG1648	precorrin-2 dehydrogenase activity
O23A_RS21560	COG0175	sulfate reduction
O23A_RS21565	COG2895	sulfate adenylyltransferase (ATP) activity
O23A_RS21570	COG3273	potassium ion transport
O23A_RS21570	COG0471	metal ion transport
O23A_RS21575	COG0529	Catalyzes the synthesis of activated sulfate
O23A_RS21585	COG0840	transmembrane signaling receptor activity
O23A_RS21605	COG1136	(ABC) transporter
O23A_RS21620	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
O23A_RS21640	COG1940	carbohydrate kinase activity
O23A_RS21645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O23A_RS21650	COG0126	phosphoglycerate kinase activity
O23A_RS21655	COG0191	fructose-bisphosphate aldolase activity
O23A_RS21660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O23A_RS21710	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O23A_RS21715	COG1595	DNA-templated transcription, initiation
O23A_RS21720	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
O23A_RS21735	COG0481	GTPase activity
O23A_RS21745	COG0571	ribonuclease III activity
O23A_RS21755	COG1381	Involved in DNA repair and RecF pathway recombination
O23A_RS21760	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
O23A_RS21765	COG3023	N-Acetylmuramoyl-L-alanine amidase
O23A_RS21770	COG4807	Protein conserved in bacteria
O23A_RS21780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O23A_RS21785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O23A_RS21790	COG3956	TIGRFAM MazG family protein
O23A_RS21795	COG0504	CTP synthase activity
O23A_RS21800	COG0148	phosphopyruvate hydratase activity
O23A_RS21805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
O23A_RS21810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O23A_RS21820	COG0585	pseudouridine synthase activity
O23A_RS21825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
O23A_RS21830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
O23A_RS21835	COG1238	metal cluster binding
O23A_RS21840	COG1388	LysM domain
O23A_RS21840	COG4942	peptidase
O23A_RS21850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O23A_RS21855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
O23A_RS21860	COG1610	YqeY-like protein
O23A_RS21865	COG0358	DNA primase activity
O23A_RS21870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O23A_RS21905	COG0138	bifunctional purine biosynthesis protein purh
O23A_RS21915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O23A_RS21920	COG3036	rescue of stalled ribosome
O23A_RS21925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O23A_RS21930	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O23A_RS21940	COG0673	inositol 2-dehydrogenase activity
O23A_RS21950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_RS21955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O23A_RS21960	COG3227	Zinc metalloprotease (Elastase)
O23A_RS21970	COG0477	Major facilitator Superfamily
O23A_RS21980	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
O23A_RS21985	COG1027	Aspartate ammonia-lyase
O23A_RS21990	COG3030	protein affecting phage T7 exclusion by the F plasmid
O23A_RS21995	COG0534	Mate efflux family protein
O23A_RS22000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O23A_RS22005	COG0459	protein refolding
O23A_RS22015	COG3300	MHYT domain
O23A_RS22015	COG5001	Diguanylate cyclase
O23A_RS22025	COG0564	pseudouridine synthase activity
O23A_RS22030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O23A_RS22060	COG1280	lysine exporter protein (LysE YggA)
O23A_RS22065	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
O23A_RS22080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O23A_RS22110	COG0745	RESPONSE REGULATOR receiver
O23A_RS22115	COG3104	oligopeptide transport
O23A_RS22120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O23A_RS22125	COG1555	photosystem II stabilization
O23A_RS22135	COG2350	Protein conserved in bacteria
O23A_RS22140	COG2917	probably involved in intracellular septation
O23A_RS22145	COG0076	glutamate decarboxylase activity
O23A_RS22150	COG1272	protein, Hemolysin III
O23A_RS22155	COG2985	domain, Protein
O23A_RS22155	COG0569	domain protein
O23A_RS22260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O23A_RS22335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O23A_RS22395	COG3451	type IV secretory pathway VirB4
O23A_RS22450	COG2771	luxR family
O23A_RS22530	COG1192	Involved in chromosome partitioning
O23A_RS22610	COG2003	Belongs to the UPF0758 family
O23A_RS22640	COG1598	PFAM Uncharacterised protein family UPF0150
O23A_RS22645	COG1724	mRNA binding
O23A_RS22685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O23A_RS22735	COG2916	Histone family protein nucleoid-structuring protein H-NS