locus-tag	class	description
JC622_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JC622_RS00010	COG0592	DNA-directed DNA polymerase activity
JC622_RS00020	COG0187	DNA topoisomerase II activity
JC622_RS00040	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JC622_RS00070	COG1484	DNA-dependent DNA replication
JC622_RS00075	COG4584	PFAM Integrase catalytic
JC622_RS00115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JC622_RS00120	COG0071	Belongs to the small heat shock protein (HSP20) family
JC622_RS00125	COG0071	Belongs to the small heat shock protein (HSP20) family
JC622_RS00130	COG3977	Valine--pyruvate aminotransferase
JC622_RS00145	COG2814	Major facilitator Superfamily
JC622_RS00150	COG0745	RESPONSE REGULATOR receiver
JC622_RS00155	COG2205	protein histidine kinase activity
JC622_RS00175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JC622_RS00180	COG4191	Histidine kinase
JC622_RS00180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JC622_RS00185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JC622_RS00190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JC622_RS00195	COG1309	transcriptional regulator
JC622_RS00225	COG0561	phosphatase activity
JC622_RS00230	COG2267	carboxylic ester hydrolase activity
JC622_RS00240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JC622_RS00245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JC622_RS00250	COG1758	RNA polymerase activity
JC622_RS00255	COG0194	GDP metabolic process
JC622_RS00260	COG0859	PFAM glycosyl transferase family 9
JC622_RS00265	COG3642	lipopolysaccharide core region biosynthetic process
JC622_RS00305	COG0589	response to stress
JC622_RS00310	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JC622_RS00315	COG1528	Iron-storage protein
JC622_RS00320	COG2081	HI0933 family
JC622_RS00325	COG3275	phosphorelay sensor kinase activity
JC622_RS00330	COG3279	Response regulator of the LytR AlgR family
JC622_RS00335	COG2223	nitrite transmembrane transporter activity
JC622_RS00340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JC622_RS00345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JC622_RS00360	COG0583	DNA-binding transcription factor activity
JC622_RS00365	COG4206	TonB-dependent receptor
JC622_RS00410	COG1609	Transcriptional regulator
JC622_RS00415	COG3250	beta-galactosidase activity
JC622_RS00420	COG2731	YhcH YjgK YiaL family protein
JC622_RS00425	COG0531	amino acid
JC622_RS00430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JC622_RS00435	COG0531	amino acid
JC622_RS00440	COG0385	Bile acid
JC622_RS00445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JC622_RS00465	COG0583	DNA-binding transcription factor activity
JC622_RS00470	COG1561	YicC-like family, N-terminal region
JC622_RS00475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JC622_RS00480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JC622_RS00495	COG3706	GGDEF domain
JC622_RS00495	COG4251	negative regulation of phosphorylation
JC622_RS00495	COG5001	Diguanylate cyclase
JC622_RS00495	COG2203	Gaf domain
JC622_RS00500	COG3084	Protein conserved in bacteria
JC622_RS00510	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JC622_RS00515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JC622_RS00525	COG1335	isochorismatase
JC622_RS00535	COG1683	Conserved Protein
JC622_RS00540	COG0204	Acyl-transferase
JC622_RS00545	COG0204	Acyl-transferase
JC622_RS00550	COG0606	chelatase, subunit chli
JC622_RS00560	COG3978	acetolactate synthase activity
JC622_RS00570	COG0129	dihydroxy-acid dehydratase activity
JC622_RS00585	COG2391	methyltransferase activity
JC622_RS00595	COG2962	Rard protein
JC622_RS00600	COG1012	belongs to the aldehyde dehydrogenase family
JC622_RS00605	COG1396	sequence-specific DNA binding
JC622_RS00610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JC622_RS00620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JC622_RS00620	COG0519	Catalyzes the synthesis of GMP from XMP
JC622_RS00625	COG0583	DNA-binding transcription factor activity
JC622_RS00630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC622_RS00650	COG1322	Protein conserved in bacteria
JC622_RS00655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JC622_RS00660	COG2204	response regulator
JC622_RS00675	COG0174	glutamine synthetase
JC622_RS00680	COG1217	gtp-binding protein TYPA
JC622_RS00685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JC622_RS00690	COG0569	domain protein
JC622_RS00695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JC622_RS00695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JC622_RS00700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JC622_RS00705	COG0242	peptide deformylase activity
JC622_RS00710	COG1652	LysM domain
JC622_RS00715	COG0758	DNA mediated transformation
JC622_RS00720	COG2922	Belongs to the Smg family
JC622_RS00725	COG0551	DNA topoisomerase type I activity
JC622_RS00735	COG0009	L-threonylcarbamoyladenylate synthase
JC622_RS00740	COG0408	coproporphyrinogen oxidase activity
JC622_RS00745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JC622_RS00755	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JC622_RS00765	COG3078	GTPase activator activity
JC622_RS00775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JC622_RS00805	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JC622_RS00810	COG1288	antiporter activity
JC622_RS00815	COG1438	arginine binding
JC622_RS00820	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
JC622_RS00825	COG0540	Belongs to the ATCase OTCase family
JC622_RS00845	COG0583	DNA-binding transcription factor activity
JC622_RS00860	COG3040	lipid binding
JC622_RS00865	COG2207	Transcriptional regulator
JC622_RS00870	COG1979	alcohol dehydrogenase
JC622_RS00875	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JC622_RS00880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JC622_RS00890	COG2964	Protein conserved in bacteria
JC622_RS00895	COG3681	Belongs to the UPF0597 family
JC622_RS00905	COG0446	pyridine nucleotide-disulphide oxidoreductase
JC622_RS00910	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JC622_RS00915	COG0564	pseudouridine synthase activity
JC622_RS00925	COG0542	response to heat
JC622_RS00930	COG2502	aspartate--ammonia ligase
JC622_RS00935	COG1522	sequence-specific DNA binding
JC622_RS00945	COG5413	integral membrane protein
JC622_RS00950	COG0516	GMP reductase activity
JC622_RS00950	COG0517	IMP dehydrogenase activity
JC622_RS00955	COG1028	Short-chain dehydrogenase reductase Sdr
JC622_RS00970	COG2205	protein histidine kinase activity
JC622_RS00980	COG2204	response regulator
JC622_RS01025	COG0243	molybdopterin cofactor binding
JC622_RS01030	COG3005	denitrification pathway
JC622_RS01035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JC622_RS01035	COG4191	Histidine kinase
JC622_RS01065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JC622_RS01070	COG0569	domain protein
JC622_RS01075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JC622_RS01100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JC622_RS01115	COG0250	Participates in transcription elongation, termination and antitermination
JC622_RS01120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JC622_RS01125	COG0081	regulation of translation
JC622_RS01130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JC622_RS01135	COG0222	ribosome binding
JC622_RS01140	COG0085	RNA polymerase activity
JC622_RS01145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JC622_RS01150	COG2964	Protein conserved in bacteria
JC622_RS01160	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JC622_RS01165	COG2923	Belongs to the DsrF TusC family
JC622_RS01170	COG2168	tRNA wobble position uridine thiolation
JC622_RS01175	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JC622_RS01180	COG0049	tRNA binding
JC622_RS01185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JC622_RS01190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JC622_RS01195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JC622_RS01255	COG3534	alpha-L-arabinofuranosidase
JC622_RS01260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JC622_RS01275	COG2376	Dihydroxyacetone kinase
JC622_RS01280	COG1461	Dihydroxyacetone kinase
JC622_RS01300	COG2376	Dihydroxyacetone kinase
JC622_RS01315	COG3775	system Galactitol-specific IIC component
JC622_RS01320	COG3414	Phosphotransferase system galactitol-specific IIB component
JC622_RS01340	COG3655	Transcriptional regulator
JC622_RS01400	COG3714	YhhN family
JC622_RS01425	COG1301	dicarboxylic acid transport
JC622_RS01435	COG2095	MarC family integral membrane protein
JC622_RS01445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JC622_RS01455	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JC622_RS01465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JC622_RS01480	COG1770	oligopeptidase
JC622_RS01495	COG4221	oxidoreductase activity
JC622_RS01500	COG0583	DNA-binding transcription factor activity
JC622_RS01505	COG2249	NAD(P)H dehydrogenase (quinone) activity
JC622_RS01530	COG0742	ribosomal rna small subunit methyltransferase
JC622_RS01535	COG0552	protein localization to endoplasmic reticulum
JC622_RS01540	COG2884	Cell division ATP-binding protein ftsE
JC622_RS01545	COG2177	Part of the ABC transporter FtsEX involved in
JC622_RS01555	COG0288	reversible hydration of carbon dioxide
JC622_RS01560	COG2188	Transcriptional regulator
JC622_RS01565	COG1228	amidohydrolase
JC622_RS01570	COG0010	Belongs to the arginase family
JC622_RS01575	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JC622_RS01580	COG2986	histidine ammonia-lyase
JC622_RS01585	COG0387	Pfam Sodium calcium exchanger
JC622_RS01590	COG2200	EAL domain
JC622_RS01595	COG2199	diguanylate cyclase activity
JC622_RS01595	COG2200	EAL domain
JC622_RS01630	COG3385	transposase activity
JC622_RS01660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JC622_RS01665	COG1459	type II secretion system
JC622_RS01685	COG4968	Prepilin-type N-terminal cleavage methylation domain
JC622_RS01710	COG1077	Cell shape determining protein MreB Mrl
JC622_RS01715	COG1792	Involved in formation and maintenance of cell shape
JC622_RS01720	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JC622_RS01725	COG0424	maF-like protein
JC622_RS01730	COG1530	ribonuclease E activity
JC622_RS01735	COG3164	Protein of unknown function
JC622_RS01750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JC622_RS01755	COG0312	modulator of DNA gyrase
JC622_RS01770	COG0477	Major facilitator Superfamily
JC622_RS01815	COG0189	ligase activity
JC622_RS01820	COG0642	Histidine kinase
JC622_RS01825	COG0745	RESPONSE REGULATOR receiver
JC622_RS01850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JC622_RS01855	COG0352	thiamine-phosphate diphosphorylase activity
JC622_RS01860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JC622_RS01870	COG2022	thiamine diphosphate biosynthetic process
JC622_RS01875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JC622_RS01905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JC622_RS01915	COG0583	DNA-binding transcription factor activity
JC622_RS01920	COG1380	Effector of murein hydrolase LrgA
JC622_RS01925	COG1346	cytolysis
JC622_RS01935	COG4667	esterase of the alpha-beta hydrolase superfamily
JC622_RS01940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JC622_RS01945	COG1546	Belongs to the CinA family
JC622_RS01950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JC622_RS01960	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JC622_RS01965	COG0527	aspartate kinase activity
JC622_RS01970	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JC622_RS02005	COG1686	Belongs to the peptidase S11 family
JC622_RS02010	COG0586	Pfam SNARE associated Golgi protein
JC622_RS02015	COG1253	flavin adenine dinucleotide binding
JC622_RS02020	COG0252	asparaginase activity
JC622_RS02040	COG1263	PTS System
JC622_RS02040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC622_RS02045	COG0366	Alpha amylase catalytic
JC622_RS02060	COG0564	pseudouridine synthase activity
JC622_RS02065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JC622_RS02095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JC622_RS02095	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JC622_RS02110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JC622_RS02115	COG0038	chloride channel
JC622_RS02125	COG0316	Belongs to the HesB IscA family
JC622_RS02130	COG1757	Na H antiporter
JC622_RS02170	COG0297	glycogen (starch) synthase activity
JC622_RS02175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JC622_RS02180	COG2813	Specifically methylates the guanine in position
JC622_RS02185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JC622_RS02195	COG1392	Phosphate transport regulator
JC622_RS02200	COG0306	phosphate transporter
JC622_RS02205	COG0527	aspartate kinase activity
JC622_RS02205	COG0460	homoserine dehydrogenase
JC622_RS02210	COG0626	cystathionine gamma-synthase activity
JC622_RS02225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JC622_RS02230	COG0814	amino acid
JC622_RS02235	COG1218	3'(2'),5'-bisphosphate nucleotidase
JC622_RS02240	COG0494	nUDIX hydrolase
JC622_RS02245	COG1011	Hydrolase
JC622_RS02260	COG0110	maltose O-acetyltransferase activity
JC622_RS02265	COG3174	membrane
JC622_RS02270	COG3397	chitin binding
JC622_RS02275	COG0840	transmembrane signaling receptor activity
JC622_RS02290	COG0726	polysaccharide deacetylase
JC622_RS02290	COG1649	PFAM Uncharacterised BCR, COG1649
JC622_RS02295	COG1215	transferase activity, transferring glycosyl groups
JC622_RS02305	COG0543	2 iron, 2 sulfur cluster binding
JC622_RS02305	COG0633	Ferredoxin
JC622_RS02330	COG1328	CTP reductase activity
JC622_RS02335	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JC622_RS02350	COG1448	Aminotransferase
JC622_RS02390	COG0513	Belongs to the DEAD box helicase family
JC622_RS02400	COG3568	Endonuclease Exonuclease Phosphatase
JC622_RS02420	COG3112	Uncharacterised protein family (UPF0231)
JC622_RS02425	COG3835	regulator
JC622_RS02430	COG2610	gluconate transmembrane transporter activity
JC622_RS02435	COG1929	Belongs to the glycerate kinase type-1 family
JC622_RS02450	COG0583	DNA-binding transcription factor activity
JC622_RS02455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC622_RS02465	COG1872	DUF167
JC622_RS02470	COG0762	integral membrane protein
JC622_RS02475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JC622_RS02480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JC622_RS02495	COG3022	response to hydroperoxide
JC622_RS02515	COG0347	Belongs to the P(II) protein family
JC622_RS02520	COG1840	ABC-type Fe3 transport system, periplasmic component
JC622_RS02530	COG3842	ATPase activity
JC622_RS02535	COG2837	iron assimilation
JC622_RS02540	COG1438	arginine binding
JC622_RS02545	COG1126	abc transporter atp-binding protein
JC622_RS02550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JC622_RS02555	COG4215	(ABC) transporter
JC622_RS02560	COG4160	amino acid transport
JC622_RS02565	COG0039	L-malate dehydrogenase activity
JC622_RS02570	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
JC622_RS02575	COG1017	nitric oxide dioxygenase activity
JC622_RS02575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JC622_RS02585	COG4536	flavin adenine dinucleotide binding
JC622_RS02590	COG4137	Cytochrome C assembly protein
JC622_RS02595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JC622_RS02600	COG0228	four-way junction DNA binding
JC622_RS02605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JC622_RS02610	COG0336	Belongs to the RNA methyltransferase TrmD family
JC622_RS02615	COG0335	large ribosomal subunit rRNA binding
JC622_RS02625	COG3066	DNA modification
JC622_RS02630	COG1051	belongs to the nudix hydrolase family
JC622_RS02640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JC622_RS02645	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JC622_RS02650	COG4974	Belongs to the 'phage' integrase family
JC622_RS02670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JC622_RS02695	COG0446	pyridine nucleotide-disulphide oxidoreductase
JC622_RS02700	COG0426	domain, Protein
JC622_RS02700	COG1773	rubredoxin
JC622_RS02705	COG3604	Transcriptional regulator
JC622_RS02710	COG2197	response regulator
JC622_RS02720	COG3706	GGDEF domain
JC622_RS02730	COG2199	diguanylate cyclase activity
JC622_RS02730	COG2203	Gaf domain
JC622_RS02735	COG0840	transmembrane signaling receptor activity
JC622_RS02740	COG4584	PFAM Integrase catalytic
JC622_RS02745	COG1484	DNA-dependent DNA replication
JC622_RS02750	COG2199	diguanylate cyclase activity
JC622_RS02750	COG2203	Gaf domain
JC622_RS02755	COG5642	Protein of unknown function (DUF2384)
JC622_RS02765	COG2916	Histone family protein nucleoid-structuring protein H-NS
JC622_RS02795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JC622_RS02805	COG0583	DNA-binding transcription factor activity
JC622_RS02810	COG0640	Transcriptional regulator
JC622_RS02815	COG0268	Binds directly to 16S ribosomal RNA
JC622_RS02820	COG0728	peptidoglycan biosynthetic process
JC622_RS02825	COG0196	riboflavin kinase activity
JC622_RS02830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JC622_RS02835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JC622_RS02840	COG1047	Peptidyl-prolyl cis-trans
JC622_RS02845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JC622_RS02890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JC622_RS02890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JC622_RS02905	COG1854	S-ribosylhomocysteine lyase activity
JC622_RS02910	COG2165	general secretion pathway protein
JC622_RS02915	COG0084	hydrolase, TatD family'
JC622_RS02920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC622_RS02930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JC622_RS02935	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JC622_RS02940	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JC622_RS02945	COG0813	purine-nucleoside phosphorylase activity
JC622_RS02955	COG0560	Phosphoserine phosphatase
JC622_RS02970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JC622_RS02985	COG0776	regulation of translation
JC622_RS02995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JC622_RS03000	COG1914	H( )-stimulated, divalent metal cation uptake system
JC622_RS03005	COG0360	Binds together with S18 to 16S ribosomal RNA
JC622_RS03010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JC622_RS03015	COG0359	binds to the 23S rRNA
JC622_RS03020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JC622_RS03045	COG1064	alcohol dehydrogenase
JC622_RS03050	COG1238	metal cluster binding
JC622_RS03055	COG0612	Peptidase, M16
JC622_RS03060	COG2918	glutathione biosynthetic process
JC622_RS03065	COG1022	Amp-dependent synthetase and ligase
JC622_RS03075	COG0456	acetyltransferase
JC622_RS03090	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JC622_RS03100	COG1028	Short-chain dehydrogenase reductase Sdr
JC622_RS03115	COG0477	Major facilitator Superfamily
JC622_RS03120	COG0583	DNA-binding transcription factor activity
JC622_RS03130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JC622_RS03135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JC622_RS03145	COG0673	inositol 2-dehydrogenase activity
JC622_RS03155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JC622_RS03160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JC622_RS03165	COG3036	rescue of stalled ribosome
JC622_RS03175	COG0138	bifunctional purine biosynthesis protein purh
JC622_RS03180	COG0151	Belongs to the GarS family
JC622_RS03200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JC622_RS03205	COG0358	DNA primase activity
JC622_RS03210	COG1610	YqeY-like protein
JC622_RS03215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JC622_RS03220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JC622_RS03225	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JC622_RS03230	COG1027	Aspartate ammonia-lyase
JC622_RS03235	COG3030	protein affecting phage T7 exclusion by the F plasmid
JC622_RS03240	COG0534	Mate efflux family protein
JC622_RS03245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JC622_RS03250	COG0459	protein refolding
JC622_RS03295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JC622_RS03305	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JC622_RS03310	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
JC622_RS03315	COG1178	ABC-type Fe3 transport system permease component
JC622_RS03320	COG4143	(ABC) transporter
JC622_RS03335	COG0066	3-isopropylmalate dehydratase activity
JC622_RS03340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JC622_RS03345	COG0473	3-isopropylmalate dehydrogenase activity
JC622_RS03350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JC622_RS03375	COG0028	Belongs to the TPP enzyme family
JC622_RS03380	COG0440	acetolactate synthase activity
JC622_RS03395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JC622_RS03410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JC622_RS03440	COG0745	RESPONSE REGULATOR receiver
JC622_RS03450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JC622_RS03455	COG1555	photosystem II stabilization
JC622_RS03460	COG0280	phosphate acetyltransferase
JC622_RS03460	COG0857	belongs to the CobB CobQ family
JC622_RS03465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JC622_RS03475	COG3013	Belongs to the UPF0304 family
JC622_RS03480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JC622_RS03485	COG2716	regulation of RNA biosynthetic process
JC622_RS03490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JC622_RS03495	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JC622_RS03500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JC622_RS03535	COG0784	Response regulator, receiver
JC622_RS03535	COG5002	protein histidine kinase activity
JC622_RS03535	COG2198	Histidine kinase
JC622_RS03570	COG1464	Belongs to the NlpA lipoprotein family
JC622_RS03575	COG2011	ABC-type metal ion transport system permease component
JC622_RS03580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JC622_RS03600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JC622_RS03600	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JC622_RS03605	COG0802	atpase or kinase
JC622_RS03615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JC622_RS03620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JC622_RS03625	COG1923	regulation of RNA biosynthetic process
JC622_RS03630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JC622_RS03635	COG0330	HflC and HflK could
JC622_RS03640	COG0330	HflC and HflK could
JC622_RS03645	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
JC622_RS03650	COG0142	geranyltranstransferase activity
JC622_RS03655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JC622_RS03660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JC622_RS03665	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JC622_RS03670	COG3314	Sporulation integral membrane protein YlbJ
JC622_RS03680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JC622_RS03690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JC622_RS03695	COG2967	ApaG domain
JC622_RS03700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JC622_RS03705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JC622_RS03710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JC622_RS03715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JC622_RS03720	COG3178	'Phosphotransferase
JC622_RS03725	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JC622_RS03730	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JC622_RS03735	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC622_RS03740	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JC622_RS03745	COG1073	alpha beta
JC622_RS03760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JC622_RS03775	COG4628	conserved protein (DUF2132)
JC622_RS03780	COG0688	phosphatidylethanolamine metabolic process
JC622_RS03785	COG1162	GTPase activity
JC622_RS03790	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JC622_RS03825	COG1278	Cold shock
JC622_RS03835	COG0840	transmembrane signaling receptor activity
JC622_RS03840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JC622_RS03845	COG2252	PERMEase
JC622_RS03855	COG0488	(ABC) transporter
JC622_RS03870	COG0741	lytic transglycosylase activity
JC622_RS03880	COG3416	Protein conserved in bacteria
JC622_RS03885	COG0583	DNA-binding transcription factor activity
JC622_RS03890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JC622_RS03895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC622_RS03900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JC622_RS03925	COG4608	Belongs to the ABC transporter superfamily
JC622_RS03930	COG0444	Belongs to the ABC transporter superfamily
JC622_RS03940	COG4239	(ABC) transporter, permease
JC622_RS03945	COG4174	ABC transporter (Permease)
JC622_RS03950	COG4206	TonB-dependent receptor
JC622_RS03960	COG0811	peptide transport
JC622_RS03965	COG0811	peptide transport
JC622_RS03970	COG0848	biopolymer transport protein
JC622_RS03990	COG0616	signal peptide processing
JC622_RS03995	COG1902	pentaerythritol trinitrate reductase activity
JC622_RS03995	COG0446	pyridine nucleotide-disulphide oxidoreductase
JC622_RS04000	COG0778	Nitroreductase
JC622_RS04005	COG0110	maltose O-acetyltransferase activity
JC622_RS04010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JC622_RS04015	COG2264	protein methyltransferase activity
JC622_RS04020	COG0604	alcohol dehydrogenase
JC622_RS04030	COG0583	DNA-binding transcription factor activity
JC622_RS04035	COG1263	PTS System
JC622_RS04035	COG2190	(PTS) system
JC622_RS04035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC622_RS04040	COG4145	pantothenate transmembrane transporter activity
JC622_RS04050	COG0439	Biotin carboxylase
JC622_RS04055	COG0511	ligase activity, forming carbon-carbon bonds
JC622_RS04060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JC622_RS04065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JC622_RS04085	COG3381	protein complex oligomerization
JC622_RS04095	COG3005	denitrification pathway
JC622_RS04100	COG0745	RESPONSE REGULATOR receiver
JC622_RS04110	COG1879	ABC-type sugar transport system periplasmic component
JC622_RS04115	COG0784	Response regulator, receiver
JC622_RS04115	COG2205	protein histidine kinase activity
JC622_RS04115	COG2198	Histidine kinase
JC622_RS04125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JC622_RS04130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JC622_RS04135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JC622_RS04135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JC622_RS04150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JC622_RS04155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JC622_RS04160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JC622_RS04165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JC622_RS04180	COG0601	transmembrane transport
JC622_RS04190	COG2900	Belongs to the SlyX family
JC622_RS04200	COG0545	Peptidyl-prolyl cis-trans isomerase
JC622_RS04205	COG2204	response regulator
JC622_RS04225	COG0737	Belongs to the 5'-nucleotidase family
JC622_RS04230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JC622_RS04235	COG0142	geranyltranstransferase activity
JC622_RS04240	COG1722	exodeoxyribonuclease VII activity
JC622_RS04245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JC622_RS04250	COG1360	Flagellar Motor Protein
JC622_RS04265	COG1534	Rna-binding protein
JC622_RS04270	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JC622_RS04280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JC622_RS04285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JC622_RS04290	COG0149	triose-phosphate isomerase activity
JC622_RS04295	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JC622_RS04310	COG0779	Required for maturation of 30S ribosomal subunits
JC622_RS04315	COG0195	Participates in both transcription termination and antitermination
JC622_RS04320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JC622_RS04325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JC622_RS04330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JC622_RS04335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JC622_RS04340	COG1185	polyribonucleotide nucleotidyltransferase activity
JC622_RS04345	COG2201	protein-glutamate methylesterase activity
JC622_RS04350	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
JC622_RS04360	COG0840	transmembrane signaling receptor activity
JC622_RS04365	COG0835	chemotaxis
JC622_RS04385	COG0745	RESPONSE REGULATOR receiver
JC622_RS04395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JC622_RS04405	COG1280	lysine exporter protein (LysE YggA)
JC622_RS04410	COG0826	peptidase U32
JC622_RS04455	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JC622_RS04480	COG0300	oxidoreductase activity
JC622_RS04490	COG0840	transmembrane signaling receptor activity
JC622_RS04525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JC622_RS04570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JC622_RS04595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JC622_RS04635	COG2003	Belongs to the UPF0758 family
JC622_RS04655	COG5377	YqaJ viral recombinase family
JC622_RS04685	COG0077	Prephenate dehydratase
JC622_RS04685	COG1605	Chorismate mutase
JC622_RS04715	COG3272	Protein of unknown function (DUF1722)
JC622_RS04720	COG0789	Transcriptional regulator
JC622_RS04725	COG0415	Belongs to the DNA photolyase family
JC622_RS04735	COG0300	oxidoreductase activity
JC622_RS04750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JC622_RS04780	COG1477	protein flavinylation
JC622_RS04785	COG2871	sodium ion transport
JC622_RS04790	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JC622_RS04795	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JC622_RS04800	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JC622_RS04805	COG1805	sodium ion transport
JC622_RS04810	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JC622_RS04815	COG0271	Belongs to the BolA IbaG family
JC622_RS04820	COG2813	Specifically methylates the guanine in position
JC622_RS04830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JC622_RS04835	COG2211	Major facilitator Superfamily
JC622_RS04845	COG1666	GTP binding
JC622_RS04850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JC622_RS04865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JC622_RS04870	COG0840	transmembrane signaling receptor activity
JC622_RS04875	COG0583	DNA-binding transcription factor activity
JC622_RS04885	COG2363	Small membrane protein
JC622_RS04890	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
JC622_RS04900	COG0473	3-isopropylmalate dehydrogenase activity
JC622_RS04905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC622_RS04910	COG1611	Belongs to the LOG family
JC622_RS04925	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JC622_RS04925	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JC622_RS04935	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
JC622_RS04960	COG3098	single-species biofilm formation
JC622_RS04965	COG0564	pseudouridine synthase activity
JC622_RS05005	COG2171	N-acyltransferase activity
JC622_RS05015	COG0024	Methionine aminopeptidase
JC622_RS05020	COG0052	Belongs to the universal ribosomal protein uS2 family
JC622_RS05025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JC622_RS05030	COG0528	UMP kinase activity
JC622_RS05035	COG0233	cytoplasmic translational termination
JC622_RS05040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JC622_RS05045	COG0575	Belongs to the CDS family
JC622_RS05050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JC622_RS05055	COG0750	zinc metalloprotease
JC622_RS05060	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JC622_RS05070	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JC622_RS05075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JC622_RS05080	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JC622_RS05085	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JC622_RS05090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JC622_RS05100	COG0825	malonyl-CoA metabolic process
JC622_RS05110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JC622_RS05115	COG1115	amino acid carrier protein
JC622_RS05130	COG0714	Associated with various cellular activities
JC622_RS05150	COG3104	oligopeptide transport
JC622_RS05155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JC622_RS05160	COG1678	Uncharacterized ACR, COG1678
JC622_RS05165	COG0189	ligase activity
JC622_RS05170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JC622_RS05180	COG3091	SprT-like family
JC622_RS05190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JC622_RS05225	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JC622_RS05230	COG0739	heme binding
JC622_RS05235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JC622_RS05265	COG0814	amino acid
JC622_RS05285	COG0531	amino acid
JC622_RS05295	COG0488	(ABC) transporter
JC622_RS05300	COG3710	Transcriptional regulator
JC622_RS05310	COG0531	amino acid
JC622_RS05315	COG1982	Orn Lys Arg decarboxylase major
JC622_RS05320	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JC622_RS05330	COG3590	peptidase
JC622_RS05340	COG2203	Gaf domain
JC622_RS05340	COG2199	diguanylate cyclase activity
JC622_RS05375	COG0366	Alpha amylase catalytic
JC622_RS05390	COG0463	Glycosyl transferase, family 2
JC622_RS05405	COG2989	Protein conserved in bacteria
JC622_RS05410	COG3108	Peptidase M15
JC622_RS05420	COG2860	membrane
JC622_RS05430	COG1196	nuclear chromosome segregation
JC622_RS05435	COG3115	cell septum assembly
JC622_RS05440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JC622_RS05450	COG1328	CTP reductase activity
JC622_RS05455	COG0602	queuosine metabolic process
JC622_RS05485	COG1566	PFAM secretion protein HlyD family protein
JC622_RS05490	COG1846	Transcriptional regulator
JC622_RS05510	COG0281	malic enzyme
JC622_RS05515	COG3290	protein histidine kinase activity
JC622_RS05525	COG0697	spore germination
JC622_RS05540	COG3284	Transcriptional regulator
JC622_RS05545	COG0346	lactoylglutathione lyase activity
JC622_RS05550	COG0745	RESPONSE REGULATOR receiver
JC622_RS05555	COG5002	protein histidine kinase activity
JC622_RS05580	COG3142	Participates in the control of copper homeostasis
JC622_RS05585	COG0545	Peptidyl-prolyl cis-trans isomerase
JC622_RS05610	COG0678	peroxiredoxin activity
JC622_RS05620	COG0019	diaminopimelate decarboxylase activity
JC622_RS05625	COG1115	amino acid carrier protein
JC622_RS05630	COG0095	Lipoate-protein ligase
JC622_RS05635	COG2233	PERMEase
JC622_RS05650	COG0534	Mate efflux family protein
JC622_RS05660	COG0281	malic enzyme
JC622_RS05690	COG0531	amino acid
JC622_RS05695	COG1752	Esterase of the alpha-beta hydrolase superfamily
JC622_RS05700	COG3706	GGDEF domain
JC622_RS05705	COG1566	PFAM secretion protein HlyD family protein
JC622_RS05715	COG1032	radical SAM domain protein
JC622_RS05745	COG0583	DNA-binding transcription factor activity
JC622_RS05750	COG0673	inositol 2-dehydrogenase activity
JC622_RS05755	COG2920	part of a sulfur-relay system
JC622_RS05760	COG1289	transmembrane transporter activity
JC622_RS05765	COG0670	Belongs to the BI1 family
JC622_RS05775	COG3318	Belongs to the UPF0149 family
JC622_RS05775	COG3012	SEC-C Motif Domain Protein
JC622_RS05850	COG2003	Belongs to the UPF0758 family
JC622_RS05905	COG4983	Phage plasmid primase, P4 family domain protein
JC622_RS05920	COG2916	Histone family protein nucleoid-structuring protein H-NS
JC622_RS05930	COG0582	viral genome integration into host DNA
JC622_RS05940	COG1486	melibiose metabolic process
JC622_RS05945	COG2169	Transcriptional regulator
JC622_RS05945	COG1917	Cupin 2, conserved barrel domain protein
JC622_RS05950	COG1447	Phosphotransferase system cellobiose-specific component IIA
JC622_RS05955	COG2723	6-phospho-beta-galactosidase activity
JC622_RS05960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JC622_RS05965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JC622_RS05975	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JC622_RS05985	COG3156	type II secretion system protein K
JC622_RS05995	COG2165	general secretion pathway protein
JC622_RS06005	COG2165	general secretion pathway protein
JC622_RS06010	COG1459	type II secretion system
JC622_RS06015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JC622_RS06035	COG3409	Peptidoglycan-binding domain 1 protein
JC622_RS06035	COG3267	Type II secretory pathway component ExeA
JC622_RS06040	COG3437	response regulator, receiver
JC622_RS06040	COG2770	Histidine kinase
JC622_RS06055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JC622_RS06060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JC622_RS06065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS06075	COG2190	(PTS) system
JC622_RS06080	COG3706	GGDEF domain
JC622_RS06085	COG3590	peptidase
JC622_RS06095	COG3264	Mechanosensitive ion channel
JC622_RS06095	COG1196	nuclear chromosome segregation
JC622_RS06100	COG0469	pyruvate kinase activity
JC622_RS06110	COG3384	dioxygenase
JC622_RS06115	COG0419	ATPase involved in DNA repair
JC622_RS06120	COG0420	3'-5' exonuclease activity
JC622_RS06130	COG2974	May be involved in recombination
JC622_RS06135	COG0405	Gamma-glutamyltransferase
JC622_RS06140	COG0545	Peptidyl-prolyl cis-trans isomerase
JC622_RS06145	COG1283	sodium-dependent phosphate transmembrane transporter activity
JC622_RS06155	COG0531	amino acid
JC622_RS06165	COG0531	amino acid
JC622_RS06180	COG1917	Cupin 2, conserved barrel domain protein
JC622_RS06180	COG1396	sequence-specific DNA binding
JC622_RS06185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JC622_RS06200	COG2862	Uncharacterized protein family, UPF0114
JC622_RS06220	COG3038	cytochrome b561
JC622_RS06225	COG1720	tRNA m6t6A37 methyltransferase activity
JC622_RS06245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JC622_RS06250	COG4988	ABC transporter
JC622_RS06265	COG0745	RESPONSE REGULATOR receiver
JC622_RS06275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JC622_RS06305	COG0798	PFAM Bile acid sodium symporter
JC622_RS06310	COG1393	Belongs to the ArsC family
JC622_RS06315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC622_RS06335	COG3328	transposase activity
JC622_RS06340	COG1988	membrane-bound metal-dependent
JC622_RS06350	COG0159	tryptophan synthase activity
JC622_RS06355	COG0133	tryptophan synthase activity
JC622_RS06360	COG0134	indole-3-glycerol-phosphate synthase activity
JC622_RS06360	COG0135	phosphoribosylanthranilate isomerase activity
JC622_RS06365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JC622_RS06370	COG0512	Glutamine amidotransferase of anthranilate synthase
JC622_RS06370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JC622_RS06375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JC622_RS06385	COG0009	L-threonylcarbamoyladenylate synthase
JC622_RS06395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JC622_RS06405	COG1946	Acyl-CoA thioesterase
JC622_RS06410	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
JC622_RS06415	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JC622_RS06425	COG0083	homoserine kinase activity
JC622_RS06430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JC622_RS06445	COG0789	Transcriptional regulator
JC622_RS06465	COG4792	protein secretion
JC622_RS06470	COG4791	protein targeting
JC622_RS06475	COG4794	Type iii secretion
JC622_RS06480	COG4790	Type iii secretion
JC622_RS06550	COG0457	Tetratricopeptide repeat
JC622_RS06565	COG3328	transposase activity
JC622_RS06650	COG1317	bacterial-type flagellum organization
JC622_RS06655	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JC622_RS06665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JC622_RS06670	COG1960	acyl-CoA dehydrogenase activity
JC622_RS06680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JC622_RS06690	COG1940	carbohydrate kinase activity
JC622_RS06695	COG0457	Tetratricopeptide repeat
JC622_RS06700	COG0477	Major facilitator Superfamily
JC622_RS06700	COG2814	Major facilitator Superfamily
JC622_RS06710	COG1349	DNA-binding transcription factor activity
JC622_RS06720	COG2222	sugar isomerase
JC622_RS06725	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS06730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JC622_RS06740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC622_RS06745	COG3715	PTS system
JC622_RS06750	COG3716	PTS system mannose fructose sorbose family IID component
JC622_RS06755	COG4821	SIS domain
JC622_RS06760	COG4821	SIS domain
JC622_RS06770	COG3383	formate dehydrogenase (NAD+) activity
JC622_RS06780	COG2205	protein histidine kinase activity
JC622_RS06780	COG0784	Response regulator, receiver
JC622_RS06820	COG2974	May be involved in recombination
JC622_RS06855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JC622_RS06955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JC622_RS07015	COG3646	Phage regulatory protein
JC622_RS07100	COG3561	AntA/AntB antirepressor
JC622_RS07165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JC622_RS07170	COG2867	negative regulation of translational initiation
JC622_RS07175	COG2914	Belongs to the UPF0125 (RnfH) family
JC622_RS07180	COG1473	amidohydrolase
JC622_RS07185	COG1960	acyl-CoA dehydrogenase activity
JC622_RS07190	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JC622_RS07195	COG0121	glutamine amidotransferase
JC622_RS07225	COG2197	response regulator
JC622_RS07230	COG3850	Histidine kinase
JC622_RS07235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JC622_RS07240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JC622_RS07250	COG0243	molybdopterin cofactor binding
JC622_RS07255	COG0437	4 iron, 4 sulfur cluster binding
JC622_RS07260	COG0348	domain, Protein
JC622_RS07270	COG3005	denitrification pathway
JC622_RS07275	COG0521	Mo-molybdopterin cofactor biosynthetic process
JC622_RS07280	COG0315	cyclic pyranopterin monophosphate synthase activity
JC622_RS07285	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JC622_RS07290	COG0314	molybdopterin synthase activity
JC622_RS07305	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JC622_RS07310	COG2267	carboxylic ester hydrolase activity
JC622_RS07315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JC622_RS07325	COG0302	gtp cyclohydrolase
JC622_RS07330	COG0840	transmembrane signaling receptor activity
JC622_RS07335	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JC622_RS07345	COG0583	DNA-binding transcription factor activity
JC622_RS07350	COG2353	YceI-like domain
JC622_RS07360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JC622_RS07375	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC622_RS07380	COG1166	arginine decarboxylase activity
JC622_RS07390	COG2015	COG2015, Alkyl sulfatase and related hydrolases
JC622_RS07410	COG0814	amino acid
JC622_RS07420	COG3681	Belongs to the UPF0597 family
JC622_RS07425	COG2964	Protein conserved in bacteria
JC622_RS07440	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JC622_RS07445	COG1288	antiporter activity
JC622_RS07450	COG0436	Aminotransferase
JC622_RS07460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JC622_RS07465	COG0739	heme binding
JC622_RS07465	COG0741	lytic transglycosylase activity
JC622_RS07465	COG1196	nuclear chromosome segregation
JC622_RS07480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JC622_RS07490	COG0788	formyltetrahydrofolate deformylase activity
JC622_RS07495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JC622_RS07515	COG0791	NLP P60 protein
JC622_RS07520	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JC622_RS07530	COG0471	metal ion transport
JC622_RS07540	COG1388	LysM domain
JC622_RS07540	COG1376	ErfK ybiS ycfS ynhG family protein
JC622_RS07550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JC622_RS07555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JC622_RS07560	COG0745	RESPONSE REGULATOR receiver
JC622_RS07565	COG5000	phosphorelay sensor kinase activity
JC622_RS07565	COG5002	protein histidine kinase activity
JC622_RS07590	COG0741	lytic transglycosylase activity
JC622_RS07590	COG1388	LysM domain
JC622_RS07595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JC622_RS07600	COG2226	methyltransferase
JC622_RS07605	COG0328	RNA-DNA hybrid ribonuclease activity
JC622_RS07610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JC622_RS07625	COG5433	transposase activity
JC622_RS07635	COG2375	cellular response to nickel ion
JC622_RS07640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC622_RS07645	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC622_RS07650	COG1120	ATPase activity
JC622_RS07655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC622_RS07665	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JC622_RS07670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JC622_RS07695	COG0708	Exodeoxyribonuclease III
JC622_RS07725	COG3132	Protein of unknown function, DUF480
JC622_RS07730	COG5001	Diguanylate cyclase
JC622_RS07730	COG3300	MHYT domain
JC622_RS07740	COG2841	Protein conserved in bacteria
JC622_RS07750	COG0534	Mate efflux family protein
JC622_RS07780	COG1309	transcriptional regulator
JC622_RS07815	COG3152	Membrane
JC622_RS07830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC622_RS07835	COG3537	Alpha-1,2-mannosidase
JC622_RS07850	COG3537	Alpha-1,2-mannosidase
JC622_RS07860	COG2207	Transcriptional regulator
JC622_RS07865	COG0538	isocitrate dehydrogenase activity
JC622_RS07875	COG3048	D-serine ammonia-lyase activity
JC622_RS07880	COG2610	gluconate transmembrane transporter activity
JC622_RS07885	COG0583	DNA-binding transcription factor activity
JC622_RS07895	COG0791	NLP P60 protein
JC622_RS07900	COG0583	DNA-binding transcription factor activity
JC622_RS07905	COG0450	alkyl hydroperoxide reductase
JC622_RS07925	COG0500	methyltransferase
JC622_RS07930	COG4106	trans-aconitate 2-methyltransferase activity
JC622_RS07935	COG1801	Protein of unknown function DUF72
JC622_RS07945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JC622_RS07950	COG0217	transcriptional regulatory protein
JC622_RS07955	COG1454	alcohol dehydrogenase
JC622_RS07955	COG1012	belongs to the aldehyde dehydrogenase family
JC622_RS07960	COG2095	MarC family integral membrane protein
JC622_RS07970	COG0601	transmembrane transport
JC622_RS07975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC622_RS07990	COG0861	Integral membrane protein TerC family
JC622_RS07995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JC622_RS08025	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
JC622_RS08030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JC622_RS08035	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JC622_RS08040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JC622_RS08045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JC622_RS08050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JC622_RS08065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JC622_RS08075	COG0505	Belongs to the CarA family
JC622_RS08080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JC622_RS08090	COG0287	Prephenate dehydrogenase
JC622_RS08090	COG1605	Chorismate mutase
JC622_RS08095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JC622_RS08105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC622_RS08110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC622_RS08145	COG0537	adenosine 5'-monophosphoramidase activity
JC622_RS08160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JC622_RS08175	COG1301	dicarboxylic acid transport
JC622_RS08180	COG0840	transmembrane signaling receptor activity
JC622_RS08190	COG2354	Protein conserved in bacteria
JC622_RS08200	COG2233	PERMEase
JC622_RS08205	COG3150	esterase
JC622_RS08210	COG1252	NADH dehydrogenase
JC622_RS08220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JC622_RS08225	COG3300	MHYT domain
JC622_RS08225	COG5001	Diguanylate cyclase
JC622_RS08230	COG0446	pyridine nucleotide-disulphide oxidoreductase
JC622_RS08240	COG2373	Large extracellular alpha-helical protein
JC622_RS08245	COG4953	penicillin-binding protein 1C
JC622_RS08255	COG0301	tRNA thio-modification
JC622_RS08255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JC622_RS08315	COG2089	acid synthase
JC622_RS08330	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JC622_RS08340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JC622_RS08345	COG1086	Polysaccharide biosynthesis protein
JC622_RS08360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JC622_RS08370	COG0483	inositol monophosphate 1-phosphatase activity
JC622_RS08380	COG0625	glutathione transferase activity
JC622_RS08385	COG2814	Major facilitator Superfamily
JC622_RS08400	COG3079	Belongs to the UPF0149 family
JC622_RS08405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JC622_RS08410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JC622_RS08420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JC622_RS08425	COG0509	glycine decarboxylation via glycine cleavage system
JC622_RS08430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JC622_RS08430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JC622_RS08435	COG0840	transmembrane signaling receptor activity
JC622_RS08460	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JC622_RS08465	COG0574	Belongs to the PEP-utilizing enzyme family
JC622_RS08465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JC622_RS08480	COG1464	Belongs to the NlpA lipoprotein family
JC622_RS08485	COG3083	sulfuric ester hydrolase activity
JC622_RS08490	COG3082	Protein of unknown function (DUF1414)
JC622_RS08495	COG3081	Nucleoid-associated protein
JC622_RS08505	COG1175	transmembrane transport
JC622_RS08510	COG3833	ABC-type maltose transport systems, permease component
JC622_RS08515	COG3842	ATPase activity
JC622_RS08540	COG0425	Belongs to the sulfur carrier protein TusA family
JC622_RS08545	COG4783	chaperone-mediated protein folding
JC622_RS08550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC622_RS08555	COG1393	Belongs to the ArsC family
JC622_RS08565	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
JC622_RS08570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JC622_RS08575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JC622_RS08580	COG2431	L-lysine efflux transmembrane transporter activity
JC622_RS08590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JC622_RS08600	COG4160	amino acid transport
JC622_RS08610	COG0564	pseudouridine synthase activity
JC622_RS08625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JC622_RS08635	COG0625	glutathione transferase activity
JC622_RS08645	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC622_RS08650	COG3069	C4-dicarboxylate transmembrane transporter activity
JC622_RS08660	COG0367	asparagine synthase
JC622_RS08670	COG4651	solute:proton antiporter activity
JC622_RS08670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JC622_RS08675	COG0647	UMP catabolic process
JC622_RS08690	COG1902	pentaerythritol trinitrate reductase activity
JC622_RS08695	COG1253	flavin adenine dinucleotide binding
JC622_RS08820	COG0640	Transcriptional regulator
JC622_RS08830	COG4373	Mu-like prophage FluMu protein gp28
JC622_RS08835	COG4383	Mu-like prophage protein gp29
JC622_RS08855	COG4388	Caudovirus prohead serine protease
JC622_RS08860	COG4397	Mu-like prophage major head subunit gpT
JC622_RS08935	COG0247	lactate metabolic process
JC622_RS08935	COG0277	FAD linked oxidase domain protein
JC622_RS08945	COG2050	protein possibly involved in aromatic compounds catabolism
JC622_RS08960	COG3300	MHYT domain
JC622_RS08960	COG5001	Diguanylate cyclase
JC622_RS08965	COG2056	Na+-H+ antiporter family
JC622_RS08970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JC622_RS08975	COG0671	phosphoesterase, PA-phosphatase related
JC622_RS08980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JC622_RS08985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JC622_RS08995	COG0101	tRNA pseudouridine synthase activity
JC622_RS09000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JC622_RS09005	COG0285	dihydrofolate synthase activity
JC622_RS09010	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
JC622_RS09015	COG0393	Putative heavy-metal-binding
JC622_RS09025	COG1648	precorrin-2 dehydrogenase activity
JC622_RS09025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JC622_RS09045	COG4667	esterase of the alpha-beta hydrolase superfamily
JC622_RS09050	COG1619	proteins homologs of microcin C7 resistance protein MccF
JC622_RS09055	COG1368	sulfuric ester hydrolase activity
JC622_RS09065	COG0527	aspartate kinase activity
JC622_RS09070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JC622_RS09070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JC622_RS09075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JC622_RS09095	COG0596	Alpha beta hydrolase
JC622_RS09120	COG0577	efflux transmembrane transporter activity
JC622_RS09125	COG1136	(ABC) transporter
JC622_RS09140	COG2814	Major facilitator Superfamily
JC622_RS09160	COG0672	)-iron permease
JC622_RS09195	COG3039	Transposase
JC622_RS09230	COG0393	Putative heavy-metal-binding
JC622_RS09290	COG0582	viral genome integration into host DNA
JC622_RS09305	COG0659	secondary active sulfate transmembrane transporter activity
JC622_RS09330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JC622_RS09345	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JC622_RS09345	COG0392	lysyltransferase activity
JC622_RS09360	COG2205	protein histidine kinase activity
JC622_RS09365	COG0745	RESPONSE REGULATOR receiver
JC622_RS09385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JC622_RS09390	COG1278	Cold shock
JC622_RS09395	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JC622_RS09400	COG0542	response to heat
JC622_RS09405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JC622_RS09410	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
JC622_RS09415	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JC622_RS09420	COG3134	Outer membrane lipoprotein
JC622_RS09425	COG3706	GGDEF domain
JC622_RS09430	COG0492	ferredoxin-NADP+ reductase activity
JC622_RS09435	COG0686	Belongs to the AlaDH PNT family
JC622_RS09445	COG0531	amino acid
JC622_RS09445	COG1674	ftsk spoiiie
JC622_RS09450	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JC622_RS09455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JC622_RS09460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JC622_RS09465	COG1286	toxin biosynthetic process
JC622_RS09470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JC622_RS09480	COG0563	adenylate kinase activity
JC622_RS09485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JC622_RS09495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC622_RS09510	COG5001	Diguanylate cyclase
JC622_RS09510	COG3300	MHYT domain
JC622_RS09560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JC622_RS09565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JC622_RS09570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JC622_RS09585	COG0513	Belongs to the DEAD box helicase family
JC622_RS09590	COG0386	Belongs to the glutathione peroxidase family
JC622_RS09635	COG1181	Belongs to the D-alanine--D-alanine ligase family
JC622_RS09640	COG0383	alpha-mannosidase activity
JC622_RS09645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC622_RS09645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC622_RS09645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS09650	COG2188	Transcriptional regulator
JC622_RS09655	COG1570	exodeoxyribonuclease VII activity
JC622_RS09660	COG3038	cytochrome b561
JC622_RS09665	COG0517	IMP dehydrogenase activity
JC622_RS09665	COG0516	GMP reductase activity
JC622_RS09670	COG0519	Catalyzes the synthesis of GMP from XMP
JC622_RS09670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JC622_RS09710	COG1025	Belongs to the peptidase M16 family
JC622_RS09715	COG2062	phosphohistidine phosphatase, SixA
JC622_RS09725	COG0697	spore germination
JC622_RS09730	COG4166	transmembrane transport
JC622_RS09735	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JC622_RS09740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JC622_RS09750	COG4591	ABC-type transport system involved in lipoprotein release permease component
JC622_RS09755	COG1136	(ABC) transporter
JC622_RS09760	COG4591	ABC-type transport system involved in lipoprotein release permease component
JC622_RS09765	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JC622_RS09775	COG0544	peptidyl-prolyl cis-trans isomerase activity
JC622_RS09780	COG0740	serine-type endopeptidase activity
JC622_RS09785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JC622_RS09790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JC622_RS09795	COG0776	regulation of translation
JC622_RS09800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JC622_RS09805	COG0488	(ABC) transporter
JC622_RS09860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC622_RS09865	COG3162	membrane
JC622_RS09870	COG2176	DNA-directed DNA polymerase activity
JC622_RS09880	COG1024	Enoyl-CoA hydratase
JC622_RS09885	COG1115	amino acid carrier protein
JC622_RS09900	COG2801	Transposase and inactivated derivatives
JC622_RS09915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JC622_RS09925	COG3842	ATPase activity
JC622_RS09930	COG1840	ABC-type Fe3 transport system, periplasmic component
JC622_RS09940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JC622_RS09950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JC622_RS09965	COG3088	subunit of a heme lyase
JC622_RS09965	COG4235	cytochrome complex assembly
JC622_RS09975	COG1138	Cytochrome C-type biogenesis protein
JC622_RS09980	COG3301	Polysulphide reductase, NrfD
JC622_RS09985	COG0437	4 iron, 4 sulfur cluster binding
JC622_RS09990	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JC622_RS10010	COG0247	lactate metabolic process
JC622_RS10015	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
JC622_RS10020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JC622_RS10025	COG3012	SEC-C Motif Domain Protein
JC622_RS10030	COG0840	transmembrane signaling receptor activity
JC622_RS10035	COG1940	carbohydrate kinase activity
JC622_RS10035	COG1846	Transcriptional regulator
JC622_RS10040	COG3148	PFAM DTW domain containing protein
JC622_RS10045	COG0730	response to heat
JC622_RS10050	COG0583	DNA-binding transcription factor activity
JC622_RS10065	COG3593	DNA synthesis involved in DNA repair
JC622_RS10100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JC622_RS10105	COG1011	Hydrolase
JC622_RS10120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JC622_RS10125	COG2832	Protein of unknown function (DUF454)
JC622_RS10130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC622_RS10140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JC622_RS10145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JC622_RS10160	COG1560	Kdo2-lipid A biosynthetic process
JC622_RS10165	COG1560	Kdo2-lipid A biosynthetic process
JC622_RS10190	COG0417	DNA replication proofreading
JC622_RS10205	COG1451	nucleotide metabolic process
JC622_RS10220	COG3069	C4-dicarboxylate transmembrane transporter activity
JC622_RS10235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JC622_RS10235	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JC622_RS10240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JC622_RS10245	COG2985	domain, Protein
JC622_RS10245	COG0569	domain protein
JC622_RS10260	COG0556	nucleotide-excision repair
JC622_RS10270	COG0586	Pfam SNARE associated Golgi protein
JC622_RS10275	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JC622_RS10280	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JC622_RS10295	COG4681	YaeQ
JC622_RS10310	COG3829	transcription factor binding
JC622_RS10355	COG0307	riboflavin synthase, alpha
JC622_RS10365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JC622_RS10370	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JC622_RS10375	COG0697	spore germination
JC622_RS10380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JC622_RS10420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JC622_RS10425	COG3099	Belongs to the UPF0263 family
JC622_RS10430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JC622_RS10435	COG2894	cell division
JC622_RS10440	COG0850	regulation of cytokinetic process
JC622_RS10445	COG3100	YcgL domain-containing protein
JC622_RS10450	COG1760	l-serine dehydratase
JC622_RS10455	COG1760	l-serine dehydratase
JC622_RS10460	COG3123	guanosine phosphorylase activity
JC622_RS10465	COG5433	transposase activity
JC622_RS10470	COG3039	Transposase
JC622_RS10480	COG0205	6-phosphofructokinase activity
JC622_RS10490	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JC622_RS10495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JC622_RS10505	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
JC622_RS10510	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JC622_RS10515	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JC622_RS10550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JC622_RS10555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JC622_RS10560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC622_RS10570	COG0549	Belongs to the carbamate kinase family
JC622_RS10585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC622_RS10590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC622_RS10595	COG0697	spore germination
JC622_RS10600	COG3608	succinylglutamate desuccinylase aspartoacylase
JC622_RS10600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
JC622_RS10605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JC622_RS10610	COG2068	MobA-Related Protein
JC622_RS10615	COG0493	'glutamate synthase
JC622_RS10615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JC622_RS10620	COG0402	S-adenosylhomocysteine deaminase activity
JC622_RS10625	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
JC622_RS10630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JC622_RS10630	COG2080	2 iron, 2 sulfur cluster binding
JC622_RS10635	COG2233	PERMEase
JC622_RS10640	COG0402	S-adenosylhomocysteine deaminase activity
JC622_RS10645	COG2252	PERMEase
JC622_RS10650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JC622_RS10655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
JC622_RS10660	COG2080	2 iron, 2 sulfur cluster binding
JC622_RS10665	COG3134	Outer membrane lipoprotein
JC622_RS10675	COG0318	PFAM AMP-dependent synthetase and ligase
JC622_RS10680	COG3706	GGDEF domain
JC622_RS10690	COG2199	diguanylate cyclase activity
JC622_RS10700	COG0406	alpha-ribazole phosphatase activity
JC622_RS10705	COG3706	GGDEF domain
JC622_RS10710	COG2840	Smr protein MutS2
JC622_RS10715	COG2890	protein-(glutamine-N5) methyltransferase activity
JC622_RS10720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JC622_RS10730	COG0513	Belongs to the DEAD box helicase family
JC622_RS10745	COG3788	relative of glutathione S-transferase, MAPEG superfamily
JC622_RS10755	COG0814	amino acid
JC622_RS10760	COG1609	Transcriptional regulator
JC622_RS10765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS10765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS10770	COG1105	Belongs to the carbohydrate kinase PfkB family
JC622_RS10775	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JC622_RS10775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC622_RS10775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC622_RS10780	COG2140	Oxalate decarboxylase
JC622_RS10785	COG1609	Transcriptional regulator
JC622_RS10800	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC622_RS10800	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS10805	COG3715	PTS system
JC622_RS10810	COG3716	PTS system mannose fructose sorbose family IID component
JC622_RS10815	COG2942	2-epimerase
JC622_RS10820	COG3313	Fe-S protein
JC622_RS10825	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
JC622_RS10830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JC622_RS10835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JC622_RS10840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JC622_RS10850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JC622_RS10860	COG0366	Alpha amylase catalytic
JC622_RS10880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JC622_RS10885	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JC622_RS10890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JC622_RS10895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JC622_RS10900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JC622_RS10905	COG0072	phenylalanine-tRNA ligase activity
JC622_RS10905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JC622_RS10910	COG0776	regulation of translation
JC622_RS10915	COG0784	Response regulator, receiver
JC622_RS10915	COG2205	protein histidine kinase activity
JC622_RS10940	COG5001	Diguanylate cyclase
JC622_RS10940	COG3300	MHYT domain
JC622_RS10945	COG1609	Transcriptional regulator
JC622_RS10950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC622_RS10955	COG1879	ABC-type sugar transport system periplasmic component
JC622_RS10960	COG1172	Belongs to the binding-protein-dependent transport system permease family
JC622_RS10965	COG1129	ABC transporter
JC622_RS10970	COG1869	D-ribose catabolic process
JC622_RS10975	COG0625	glutathione transferase activity
JC622_RS10990	COG1177	transmembrane transport
JC622_RS11015	COG0037	tRNA processing
JC622_RS11020	COG0589	response to stress
JC622_RS11025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JC622_RS11040	COG2217	Heavy metal translocating P-type atpase
JC622_RS11050	COG2010	Cytochrome c
JC622_RS11065	COG3278	Belongs to the heme-copper respiratory oxidase family
JC622_RS11075	COG1956	GAF domain-containing protein
JC622_RS11080	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
JC622_RS11090	COG0308	aminopeptidase N
JC622_RS11100	COG2902	Dehydrogenase
JC622_RS11105	COG0167	dihydroorotate dehydrogenase activity
JC622_RS11115	COG0254	rRNA binding
JC622_RS11120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JC622_RS11125	COG0116	Belongs to the methyltransferase superfamily
JC622_RS11125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JC622_RS11145	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JC622_RS11150	COG3141	response to X-ray
JC622_RS11180	COG1067	ATP-dependent peptidase activity
JC622_RS11185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JC622_RS11195	COG0488	(ABC) transporter
JC622_RS11250	COG0372	Belongs to the citrate synthase family
JC622_RS11255	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JC622_RS11265	COG2995	paraquat-inducible protein a
JC622_RS11270	COG3008	intermembrane lipid transfer
JC622_RS11275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JC622_RS11275	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JC622_RS11290	COG0084	hydrolase, TatD family'
JC622_RS11295	COG0470	DNA polymerase III
JC622_RS11300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JC622_RS11305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JC622_RS11310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JC622_RS11315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JC622_RS11320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JC622_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
JC622_RS11335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JC622_RS11340	COG0416	fatty acid biosynthetic process
JC622_RS11345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JC622_RS11350	COG1399	metal-binding, possibly nucleic acid-binding protein
JC622_RS11355	COG0424	maF-like protein
JC622_RS11370	COG1530	ribonuclease E activity
JC622_RS11380	COG0306	phosphate transporter
JC622_RS11385	COG0717	Belongs to the dCTP deaminase family
JC622_RS11390	COG0572	uridine kinase
JC622_RS11395	COG0489	protein tyrosine kinase activity
JC622_RS11400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JC622_RS11400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JC622_RS11410	COG1254	Belongs to the acylphosphatase family
JC622_RS11415	COG0840	transmembrane signaling receptor activity
JC622_RS11420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JC622_RS11445	COG0709	Synthesizes selenophosphate from selenide and ATP
JC622_RS11450	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
JC622_RS11455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JC622_RS11465	COG0318	PFAM AMP-dependent synthetase and ligase
JC622_RS11470	COG2267	carboxylic ester hydrolase activity
JC622_RS11480	COG1214	PFAM Peptidase M22, glycoprotease
JC622_RS11485	COG1199	ATP-dependent helicase activity
JC622_RS11495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JC622_RS11500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JC622_RS11505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JC622_RS11510	COG0131	Imidazoleglycerol-phosphate dehydratase
JC622_RS11510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JC622_RS11515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JC622_RS11520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JC622_RS11525	COG0107	imidazoleglycerol-phosphate synthase activity
JC622_RS11545	COG2824	Alkylphosphonate utilization operon protein PhnA
JC622_RS11560	COG0494	nUDIX hydrolase
JC622_RS11565	COG0814	amino acid
JC622_RS11570	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JC622_RS11575	COG0514	ATP-dependent DNA helicase (RecQ)
JC622_RS11580	COG2766	serine protein kinase
JC622_RS11585	COG2718	Belongs to the UPF0229 family
JC622_RS11590	COG2719	SpoVR family
JC622_RS11595	COG1250	3-hydroxyacyl-CoA dehydrogenase
JC622_RS11595	COG1024	Enoyl-CoA hydratase
JC622_RS11600	COG0183	Belongs to the thiolase family
JC622_RS11605	COG0714	Associated with various cellular activities
JC622_RS11625	COG2304	oxidoreductase activity
JC622_RS11635	COG1595	DNA-templated transcription, initiation
JC622_RS11645	COG2067	long-chain fatty acid transport protein
JC622_RS11650	COG2067	long-chain fatty acid transport protein
JC622_RS11655	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JC622_RS11670	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JC622_RS11680	COG1643	Atp-dependent helicase
JC622_RS11685	COG0617	tRNA 3'-terminal CCA addition
JC622_RS11685	COG0517	IMP dehydrogenase activity
JC622_RS11685	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JC622_RS11690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JC622_RS11695	COG3119	arylsulfatase activity
JC622_RS11700	COG0714	Associated with various cellular activities
JC622_RS11715	COG2304	oxidoreductase activity
JC622_RS11720	COG2304	oxidoreductase activity
JC622_RS11745	COG0641	radical SAM
JC622_RS11750	COG2925	Exonuclease
JC622_RS11760	COG3345	alpha-galactosidase
JC622_RS11765	COG1380	Effector of murein hydrolase LrgA
JC622_RS11770	COG1346	cytolysis
JC622_RS11775	COG0295	cytidine deaminase activity
JC622_RS11780	COG3033	Beta-eliminating lyase
JC622_RS11790	COG3046	protein related to deoxyribodipyrimidine photolyase
JC622_RS11795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JC622_RS11800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JC622_RS11825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JC622_RS11835	COG3158	transport of potassium into the cell
JC622_RS11840	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JC622_RS11845	COG0651	ATP synthesis coupled electron transport
JC622_RS11850	COG0650	Formate hydrogenlyase subunit 4
JC622_RS11855	COG3261	NADH dehydrogenase
JC622_RS11855	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
JC622_RS11860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JC622_RS11865	COG3260	NADH ubiquinone oxidoreductase 20
JC622_RS11875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
JC622_RS11885	COG1921	L-seryl-tRNASec selenium transferase activity
JC622_RS11895	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
JC622_RS11900	COG0298	carbon dioxide binding
JC622_RS11910	COG0309	Hydrogenase expression formation protein (HypE)
JC622_RS11915	COG0375	protein maturation
JC622_RS11925	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JC622_RS11930	COG3842	ATPase activity
JC622_RS11940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC622_RS11955	COG1773	rubredoxin
JC622_RS11960	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
JC622_RS11965	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
JC622_RS11970	COG5557	Pfam Polysulphide reductase, NrfD
JC622_RS11975	COG0437	4 iron, 4 sulfur cluster binding
JC622_RS11980	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
JC622_RS11985	COG4251	negative regulation of phosphorylation
JC622_RS11985	COG2203	Gaf domain
JC622_RS11985	COG3706	GGDEF domain
JC622_RS11985	COG5001	Diguanylate cyclase
JC622_RS11990	COG0438	transferase activity, transferring glycosyl groups
JC622_RS11995	COG0297	glycogen (starch) synthase activity
JC622_RS12015	COG0438	transferase activity, transferring glycosyl groups
JC622_RS12070	COG0438	transferase activity, transferring glycosyl groups
JC622_RS12075	COG1215	transferase activity, transferring glycosyl groups
JC622_RS12080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JC622_RS12120	COG0784	Response regulator, receiver
JC622_RS12120	COG2205	protein histidine kinase activity
JC622_RS12130	COG0730	response to heat
JC622_RS12140	COG1028	Short-chain dehydrogenase reductase Sdr
JC622_RS12150	COG1024	Enoyl-CoA hydratase
JC622_RS12155	COG1024	Enoyl-CoA hydratase
JC622_RS12160	COG1960	acyl-CoA dehydrogenase activity
JC622_RS12165	COG1960	acyl-CoA dehydrogenase activity
JC622_RS12170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JC622_RS12175	COG1024	Enoyl-CoA hydratase
JC622_RS12205	COG1584	GPR1 FUN34 yaaH family protein
JC622_RS12220	COG0045	succinate-CoA ligase (ADP-forming) activity
JC622_RS12225	COG0508	dehydrogenase complex catalyzes the overall conversion of
JC622_RS12230	COG0567	Dehydrogenase, E1 component
JC622_RS12240	COG1053	succinate dehydrogenase
JC622_RS12245	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JC622_RS12250	COG2009	succinate dehydrogenase
JC622_RS12320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JC622_RS12375	COG5433	transposase activity
JC622_RS12385	COG5492	domain, Protein
JC622_RS12385	COG4932	domain protein
JC622_RS12410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JC622_RS12430	COG4584	PFAM Integrase catalytic
JC622_RS12435	COG1484	DNA-dependent DNA replication
JC622_RS12485	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JC622_RS12500	COG2501	S4 domain
JC622_RS12510	COG1132	(ABC) transporter
JC622_RS12515	COG1132	(ABC) transporter
JC622_RS12525	COG3118	belongs to the thioredoxin family
JC622_RS12530	COG0471	metal ion transport
JC622_RS12535	COG0058	SHG alpha-glucan phosphorylase activity
JC622_RS12550	COG2983	Belongs to the UPF0260 family
JC622_RS12560	COG1882	Formate acetyltransferase
JC622_RS12565	COG2116	formate transmembrane transporter activity
JC622_RS12570	COG1944	ATP diphosphatase activity
JC622_RS12575	COG2723	6-phospho-beta-galactosidase activity
JC622_RS12580	COG0583	DNA-binding transcription factor activity
JC622_RS12585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JC622_RS12590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JC622_RS12605	COG1335	isochorismatase
JC622_RS12620	COG0583	DNA-binding transcription factor activity
JC622_RS12625	COG0583	DNA-binding transcription factor activity
JC622_RS12630	COG2910	NAD(P)H-binding
JC622_RS12660	COG0861	Integral membrane protein TerC family
JC622_RS12665	COG2885	chlorophyll binding
JC622_RS12670	COG2199	diguanylate cyclase activity
JC622_RS12685	COG2154	pterin-4-alpha-carbinolamine dehydratase
JC622_RS12695	COG3768	UPF0283 membrane protein
JC622_RS12700	COG3106	COG3106 Predicted ATPase
JC622_RS12715	COG1842	Phage shock protein A
JC622_RS12720	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JC622_RS12730	COG4168	peptide transport system, permease
JC622_RS12740	COG4172	Belongs to the ABC transporter superfamily
JC622_RS12745	COG4172	Belongs to the ABC transporter superfamily
JC622_RS12750	COG0326	Molecular chaperone. Has ATPase activity
JC622_RS12755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JC622_RS12770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JC622_RS12780	COG3385	transposase activity
JC622_RS12815	COG1435	thymidine kinase activity
JC622_RS12820	COG1757	Na H antiporter
JC622_RS12825	COG2916	Histone family protein nucleoid-structuring protein H-NS
JC622_RS12830	COG2096	Adenosyltransferase
JC622_RS12835	COG3530	Putative quorum-sensing-regulated virulence factor
JC622_RS12840	COG0602	queuosine metabolic process
JC622_RS12845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JC622_RS12865	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JC622_RS12875	COG0776	regulation of translation
JC622_RS12880	COG0539	negative regulation of cytoplasmic translation
JC622_RS12885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JC622_RS12890	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JC622_RS12905	COG2814	Major facilitator Superfamily
JC622_RS12920	COG0778	Nitroreductase
JC622_RS12925	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JC622_RS12930	COG5001	Diguanylate cyclase
JC622_RS12930	COG3300	MHYT domain
JC622_RS12935	COG0583	DNA-binding transcription factor activity
JC622_RS12940	COG3437	response regulator, receiver
JC622_RS12965	COG4989	oxidoreductase activity
JC622_RS12970	COG0724	RNA recognition motif
JC622_RS12980	COG1126	abc transporter atp-binding protein
JC622_RS12985	COG0765	amino acid transport
JC622_RS12990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JC622_RS12995	COG4597	amino acid ABC transporter
JC622_RS13000	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
JC622_RS13010	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JC622_RS13040	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JC622_RS13060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JC622_RS13065	COG0732	type I restriction modification DNA specificity domain
JC622_RS13140	COG2003	Belongs to the UPF0758 family
JC622_RS13200	COG0789	Transcriptional regulator
JC622_RS13230	COG3263	regulation of cellular component size
JC622_RS13235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JC622_RS13250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JC622_RS13295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JC622_RS13300	COG1127	ABC transporter
JC622_RS13325	COG3041	Addiction module toxin RelE StbE family
JC622_RS13330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JC622_RS13350	COG3311	Transcriptional regulator
JC622_RS13355	COG4983	Phage plasmid primase, P4 family domain protein
JC622_RS13385	COG1484	DNA-dependent DNA replication
JC622_RS13390	COG4584	PFAM Integrase catalytic
JC622_RS13420	COG3039	Transposase
JC622_RS13435	COG0582	viral genome integration into host DNA
JC622_RS13440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JC622_RS13445	COG1360	Flagellar Motor Protein
JC622_RS13450	COG4771	TonB-dependent receptor
JC622_RS13455	COG1770	oligopeptidase
JC622_RS13475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JC622_RS13480	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JC622_RS13485	COG0649	NAD binding
JC622_RS13485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JC622_RS13500	COG1034	ATP synthesis coupled electron transport
JC622_RS13505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JC622_RS13510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JC622_RS13515	COG0839	Belongs to the complex I subunit 6 family
JC622_RS13520	COG0713	ATP synthesis coupled electron transport
JC622_RS13530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JC622_RS13535	COG1007	ATP synthesis coupled electron transport
JC622_RS13550	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JC622_RS13550	COG2199	diguanylate cyclase activity
JC622_RS13555	COG0047	phosphoribosylformylglycinamidine synthase activity
JC622_RS13555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JC622_RS13560	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JC622_RS13565	COG1645	bacterial-type flagellum-dependent swarming motility
JC622_RS13570	COG1160	GTP binding
JC622_RS13575	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JC622_RS13580	COG2976	Protein conserved in bacteria
JC622_RS13585	COG0124	histidyl-tRNA synthetase
JC622_RS13590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JC622_RS13605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JC622_RS13610	COG0105	UTP biosynthetic process
JC622_RS13625	COG0633	Ferredoxin
JC622_RS13630	COG0443	Heat shock 70 kDa protein
JC622_RS13635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JC622_RS13645	COG0822	iron-sulfur transferase activity
JC622_RS13650	COG1104	cysteine desulfurase activity
JC622_RS13670	COG3154	lipid carrier protein
JC622_RS13675	COG0826	peptidase U32
JC622_RS13680	COG0826	peptidase U32
JC622_RS13695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC622_RS13700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC622_RS13705	COG1862	Preprotein translocase
JC622_RS13710	COG0343	queuine tRNA-ribosyltransferase activity
JC622_RS13715	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JC622_RS13720	COG0517	IMP dehydrogenase activity
JC622_RS13730	COG3634	alkyl hydroperoxide reductase activity
JC622_RS13775	COG1242	4 iron, 4 sulfur cluster binding
JC622_RS13780	COG0067	glutamate synthase
JC622_RS13780	COG0069	glutamate synthase activity
JC622_RS13780	COG0070	glutamate synthase
JC622_RS13785	COG0493	'glutamate synthase
JC622_RS13795	COG0513	Belongs to the DEAD box helicase family
JC622_RS13820	COG0023	Translation Initiation Factor
JC622_RS13825	COG2119	membrane
JC622_RS13875	COG0215	cysteine-tRNA ligase activity
JC622_RS13880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JC622_RS13890	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JC622_RS13900	COG2261	transglycosylase associated protein
JC622_RS13905	COG0642	Histidine kinase
JC622_RS13940	COG1484	DNA-dependent DNA replication
JC622_RS13945	COG4584	PFAM Integrase catalytic
JC622_RS13965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JC622_RS13980	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JC622_RS13985	COG1715	Restriction endonuclease
JC622_RS13990	COG2610	gluconate transmembrane transporter activity
JC622_RS13995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC622_RS14000	COG3622	Belongs to the hyi family
JC622_RS14005	COG0235	Class ii aldolase
JC622_RS14010	COG3395	kinase activity
JC622_RS14015	COG2084	Dehydrogenase
JC622_RS14020	COG1349	DNA-binding transcription factor activity
JC622_RS14055	COG1012	belongs to the aldehyde dehydrogenase family
JC622_RS14055	COG1454	alcohol dehydrogenase
JC622_RS14065	COG1454	alcohol dehydrogenase
JC622_RS14065	COG1012	belongs to the aldehyde dehydrogenase family
JC622_RS14070	COG1882	Formate acetyltransferase
JC622_RS14075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JC622_RS14085	COG4869	propanediol catabolic process
JC622_RS14130	COG0582	viral genome integration into host DNA
JC622_RS14155	COG0322	excinuclease ABC activity
JC622_RS14160	COG2197	response regulator
JC622_RS14165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JC622_RS14170	COG2835	tetraacyldisaccharide 4'-kinase activity
JC622_RS14175	COG1663	tetraacyldisaccharide 4'-kinase activity
JC622_RS14185	COG2333	competence protein COMEC
JC622_RS14185	COG0658	competence protein
JC622_RS14200	COG1448	Aminotransferase
JC622_RS14210	COG0583	DNA-binding transcription factor activity
JC622_RS14215	COG3085	chromosome segregation
JC622_RS14220	COG4574	serine-type endopeptidase inhibitor activity
JC622_RS14225	COG0584	glycerophosphoryl diester phosphodiesterase
JC622_RS14235	COG1349	DNA-binding transcription factor activity
JC622_RS14240	COG2271	Major facilitator Superfamily
JC622_RS14245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JC622_RS14250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JC622_RS14255	COG0840	transmembrane signaling receptor activity
JC622_RS14265	COG0583	DNA-binding transcription factor activity
JC622_RS14285	COG0656	L-ascorbic acid biosynthetic process
JC622_RS14295	COG2814	Major facilitator Superfamily
JC622_RS14300	COG2249	NAD(P)H dehydrogenase (quinone) activity
JC622_RS14315	COG3220	belongs to the UPF0276 family
JC622_RS14335	COG1294	oxidase, subunit
JC622_RS14345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JC622_RS14355	COG2979	Protein of unknown function (DUF533)
JC622_RS14370	COG0583	DNA-binding transcription factor activity
JC622_RS14375	COG2807	transmembrane transport
JC622_RS14380	COG1187	pseudouridine synthase activity
JC622_RS14410	COG1403	HNH endonuclease
JC622_RS14415	COG4657	Part of a membrane complex involved in electron transport
JC622_RS14420	COG2878	Part of a membrane complex involved in electron transport
JC622_RS14430	COG4658	electron transport chain
JC622_RS14435	COG4659	FMN binding
JC622_RS14440	COG4660	Part of a membrane complex involved in electron transport
JC622_RS14445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JC622_RS14450	COG0346	lactoylglutathione lyase activity
JC622_RS14500	COG1199	ATP-dependent helicase activity
JC622_RS14510	COG0123	including yeast histone deacetylase and acetoin utilization protein
JC622_RS14515	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JC622_RS14520	COG1785	Belongs to the alkaline phosphatase family
JC622_RS14540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JC622_RS14545	COG2197	response regulator
JC622_RS14555	COG2271	Major facilitator Superfamily
JC622_RS14560	COG3706	GGDEF domain
JC622_RS14565	COG3328	transposase activity
JC622_RS14570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JC622_RS14575	COG0765	amino acid transport
JC622_RS14580	COG1126	abc transporter atp-binding protein
JC622_RS14595	COG0531	amino acid
JC622_RS14610	COG1253	flavin adenine dinucleotide binding
JC622_RS14615	COG0704	Plays a role in the regulation of phosphate uptake
JC622_RS14620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JC622_RS14625	COG0581	inorganic phosphate transmembrane transporter activity
JC622_RS14630	COG0573	inorganic phosphate transmembrane transporter activity
JC622_RS14635	COG0590	tRNA wobble adenosine to inosine editing
JC622_RS14650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JC622_RS14670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JC622_RS14675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JC622_RS14680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JC622_RS14685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JC622_RS14710	COG2716	regulation of RNA biosynthetic process
JC622_RS14715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JC622_RS14725	COG2239	Acts as a magnesium transporter
JC622_RS14730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JC622_RS14745	COG1706	bacterial-type flagellum-dependent cell motility
JC622_RS14750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JC622_RS14760	COG4787	bacterial-type flagellum-dependent cell motility
JC622_RS14780	COG1815	bacterial-type flagellum-dependent cell motility
JC622_RS14785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JC622_RS14790	COG0784	Response regulator, receiver
JC622_RS14790	COG0835	chemotaxis
JC622_RS14795	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
JC622_RS14810	COG0622	Phosphoesterase
JC622_RS14815	COG4166	transmembrane transport
JC622_RS14830	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JC622_RS14840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JC622_RS14845	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JC622_RS14850	COG1882	Formate acetyltransferase
JC622_RS14855	COG1349	DNA-binding transcription factor activity
JC622_RS14860	COG4166	transmembrane transport
JC622_RS14885	COG1278	Cold shock
JC622_RS14910	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JC622_RS14910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JC622_RS14915	COG1028	Short-chain dehydrogenase reductase Sdr
JC622_RS14920	COG1535	isochorismatase
JC622_RS14920	COG3433	isochorismatase activity
JC622_RS14930	COG1021	2,3-dihydroxybenzoate-AMP ligase
JC622_RS14935	COG1169	isochorismate synthase
JC622_RS14940	COG4771	TonB-dependent receptor
JC622_RS14945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JC622_RS14950	COG1609	Transcriptional regulator
JC622_RS14955	COG0741	lytic transglycosylase activity
JC622_RS14965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JC622_RS14980	COG2911	Protein conserved in bacteria
JC622_RS14985	COG0729	surface antigen
JC622_RS14995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JC622_RS15015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JC622_RS15025	COG4134	Bacterial extracellular solute-binding protein
JC622_RS15035	COG4136	ATPase activity
JC622_RS15040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JC622_RS15045	COG2951	lytic endotransglycosylase activity
JC622_RS15050	COG1846	Transcriptional regulator
JC622_RS15060	COG0033	Phosphoglucomutase
JC622_RS15065	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JC622_RS15070	COG0596	Alpha beta hydrolase
JC622_RS15085	COG0716	FMN binding
JC622_RS15095	COG0735	belongs to the Fur family
JC622_RS15100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JC622_RS15110	COG2190	(PTS) system
JC622_RS15110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC622_RS15110	COG1263	PTS System
JC622_RS15115	COG0363	glucosamine-6-phosphate deaminase activity
JC622_RS15120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JC622_RS15125	COG1846	Transcriptional regulator
JC622_RS15125	COG1940	carbohydrate kinase activity
JC622_RS15135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JC622_RS15135	COG2199	diguanylate cyclase activity
JC622_RS15140	COG3275	phosphorelay sensor kinase activity
JC622_RS15145	COG3279	Response regulator of the LytR AlgR family
JC622_RS15150	COG1966	Carbon starvation protein
JC622_RS15160	COG1566	PFAM secretion protein HlyD family protein
JC622_RS15165	COG1061	Type III restriction enzyme res subunit
JC622_RS15170	COG2027	D-alanyl-D-alanine carboxypeptidase
JC622_RS15175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JC622_RS15180	COG3021	interspecies interaction between organisms
JC622_RS15190	COG1607	acyl-coa hydrolase
JC622_RS15195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC622_RS15210	COG1013	pyruvate-flavodoxin oxidoreductase activity
JC622_RS15210	COG0674	pyruvate-flavodoxin oxidoreductase activity
JC622_RS15210	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JC622_RS15210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JC622_RS15225	COG3217	Mosc domain protein beta barrel domain protein
JC622_RS15225	COG0633	Ferredoxin
JC622_RS15225	COG3217	Mosc domain protein beta barrel domain protein
JC622_RS15225	COG0633	Ferredoxin
JC622_RS15235	COG0501	Belongs to the peptidase M48B family
JC622_RS15240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JC622_RS15245	COG2226	methyltransferase
JC622_RS15245	COG1073	alpha beta
JC622_RS15250	COG0156	8-amino-7-oxononanoate synthase activity
JC622_RS15255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JC622_RS15260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JC622_RS15275	COG0017	Asparaginyl-tRNA synthetase
JC622_RS15285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JC622_RS15295	COG1473	amidohydrolase
JC622_RS15300	COG3069	C4-dicarboxylate transmembrane transporter activity
JC622_RS15310	COG1393	Belongs to the ArsC family
JC622_RS15315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC622_RS15320	COG1876	peptidase activity
JC622_RS15330	COG3263	regulation of cellular component size
JC622_RS15340	COG3263	regulation of cellular component size
JC622_RS15345	COG1280	lysine exporter protein (LysE YggA)
JC622_RS15375	COG0564	pseudouridine synthase activity
JC622_RS15460	COG4397	Mu-like prophage major head subunit gpT
JC622_RS15465	COG4388	Caudovirus prohead serine protease
JC622_RS15485	COG4383	Mu-like prophage protein gp29
JC622_RS15490	COG4373	Mu-like prophage FluMu protein gp28
JC622_RS15500	COG0640	Transcriptional regulator
JC622_RS15645	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JC622_RS15650	COG0702	epimerase
JC622_RS15660	COG0095	Lipoate-protein ligase
JC622_RS15670	COG1136	(ABC) transporter
JC622_RS15670	COG0577	efflux transmembrane transporter activity
JC622_RS15675	COG1136	(ABC) transporter
JC622_RS15675	COG0577	efflux transmembrane transporter activity
JC622_RS15680	COG0577	efflux transmembrane transporter activity
JC622_RS15680	COG1136	(ABC) transporter
JC622_RS15685	COG1566	PFAM secretion protein HlyD family protein
JC622_RS15720	COG0446	pyridine nucleotide-disulphide oxidoreductase
JC622_RS15730	COG1285	pathogenesis
JC622_RS15760	COG0484	heat shock protein binding
JC622_RS15765	COG0443	Heat shock 70 kDa protein
JC622_RS15770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JC622_RS15775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JC622_RS15780	COG0497	DNA recombination
JC622_RS15785	COG1227	inorganic diphosphatase activity
JC622_RS15790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JC622_RS15795	COG1136	(ABC) transporter
JC622_RS15795	COG0577	efflux transmembrane transporter activity
JC622_RS15825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JC622_RS15835	COG0297	glycogen (starch) synthase activity
JC622_RS15840	COG0438	transferase activity, transferring glycosyl groups
JC622_RS15845	COG1215	transferase activity, transferring glycosyl groups
JC622_RS15865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JC622_RS15880	COG5433	transposase activity
JC622_RS15910	COG1091	dTDP-4-dehydrorhamnose reductase activity
JC622_RS15920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JC622_RS15925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JC622_RS15930	COG1309	transcriptional regulator
JC622_RS15945	COG1342	Belongs to the UPF0251 family
JC622_RS15965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JC622_RS15990	COG0813	purine-nucleoside phosphorylase activity
JC622_RS16015	COG0783	Belongs to the Dps family
JC622_RS16045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC622_RS16045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC622_RS16045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS16050	COG2271	Major facilitator Superfamily
JC622_RS16055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC622_RS16065	COG1187	pseudouridine synthase activity
JC622_RS16075	COG0482	sulfurtransferase activity
JC622_RS16080	COG2915	High frequency lysogenization protein hflD homolog
JC622_RS16085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JC622_RS16090	COG2850	peptidyl-arginine hydroxylation
JC622_RS16110	COG0259	pyridoxamine-phosphate oxidase activity
JC622_RS16145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JC622_RS16145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JC622_RS16155	COG1882	Formate acetyltransferase
JC622_RS16160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JC622_RS16170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JC622_RS16175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JC622_RS16195	COG3088	subunit of a heme lyase
JC622_RS16195	COG4235	cytochrome complex assembly
JC622_RS16200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC622_RS16205	COG1138	Cytochrome C-type biogenesis protein
JC622_RS16210	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JC622_RS16215	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JC622_RS16220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JC622_RS16225	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JC622_RS16240	COG0835	chemotaxis
JC622_RS16250	COG1192	Involved in chromosome partitioning
JC622_RS16255	COG1360	Flagellar Motor Protein
JC622_RS16260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JC622_RS16265	COG2201	protein-glutamate methylesterase activity
JC622_RS16270	COG2198	Histidine kinase
JC622_RS16270	COG0784	Response regulator, receiver
JC622_RS16270	COG0643	Histidine kinase
JC622_RS16275	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JC622_RS16300	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JC622_RS16310	COG1684	flagellar biosynthetic protein fliR
JC622_RS16315	COG1987	bacterial-type flagellum assembly
JC622_RS16365	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JC622_RS16375	COG1677	Flagellar hook-basal body complex protein FliE
JC622_RS16395	COG0469	pyruvate kinase activity
JC622_RS16400	COG1737	Transcriptional regulator
JC622_RS16435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JC622_RS16455	COG0281	malic enzyme
JC622_RS16475	COG0437	4 iron, 4 sulfur cluster binding
JC622_RS16480	COG3383	formate dehydrogenase (NAD+) activity
JC622_RS16480	COG3383	formate dehydrogenase (NAD+) activity
JC622_RS16520	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JC622_RS16530	COG3852	Histidine kinase
JC622_RS16535	COG2204	response regulator
JC622_RS16545	COG4662	Binding-protein-dependent transport system inner membrane component
JC622_RS16555	COG0746	molybdenum cofactor guanylyltransferase activity
JC622_RS16560	COG0303	'Molybdopterin
JC622_RS16565	COG1289	transmembrane transporter activity
JC622_RS16595	COG3220	belongs to the UPF0276 family
JC622_RS16625	COG0784	Response regulator, receiver
JC622_RS16625	COG2205	protein histidine kinase activity
JC622_RS16640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC622_RS16645	COG0444	Belongs to the ABC transporter superfamily
JC622_RS16650	COG4608	Belongs to the ABC transporter superfamily
JC622_RS16660	COG2971	BadF BadG BcrA BcrD
JC622_RS16670	COG0840	transmembrane signaling receptor activity
JC622_RS16690	COG3724	N-succinylarginine dihydrolase activity
JC622_RS16720	COG2197	response regulator
JC622_RS16745	COG2199	diguanylate cyclase activity
JC622_RS16745	COG2200	EAL domain
JC622_RS16745	COG2203	Gaf domain
JC622_RS16750	COG0826	peptidase U32
JC622_RS16755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JC622_RS16765	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JC622_RS16770	COG3706	GGDEF domain
JC622_RS16775	COG2211	Major facilitator Superfamily
JC622_RS16780	COG0616	signal peptide processing
JC622_RS16785	COG1028	Short-chain dehydrogenase reductase Sdr
JC622_RS16790	COG0583	DNA-binding transcription factor activity
JC622_RS16800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JC622_RS16815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JC622_RS16820	COG1881	PFAM PEBP family protein
JC622_RS16830	COG3408	Glycogen debranching enzyme
JC622_RS16830	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
JC622_RS16840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JC622_RS16855	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JC622_RS16860	COG2912	Transglutaminase-like superfamily
JC622_RS16870	COG2890	protein-(glutamine-N5) methyltransferase activity
JC622_RS16875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JC622_RS16880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JC622_RS16885	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JC622_RS16890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JC622_RS16900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JC622_RS16905	COG0737	Belongs to the 5'-nucleotidase family
JC622_RS16910	COG0193	aminoacyl-tRNA hydrolase activity
JC622_RS16915	COG0012	GTP binding
JC622_RS16925	COG5377	YqaJ viral recombinase family
JC622_RS16965	COG2003	Belongs to the UPF0758 family
JC622_RS17015	COG1715	Restriction endonuclease
JC622_RS17025	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JC622_RS17065	COG3385	transposase activity
JC622_RS17085	COG0604	alcohol dehydrogenase
JC622_RS17095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JC622_RS17115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JC622_RS17145	COG0625	glutathione transferase activity
JC622_RS17150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JC622_RS17160	COG0583	DNA-binding transcription factor activity
JC622_RS17170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JC622_RS17205	COG1846	Transcriptional regulator
JC622_RS17210	COG0583	DNA-binding transcription factor activity
JC622_RS17220	COG2948	multi-organism process
JC622_RS17240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JC622_RS17285	COG0583	DNA-binding transcription factor activity
JC622_RS17290	COG0753	catalase activity
JC622_RS17300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JC622_RS17340	COG1484	DNA-dependent DNA replication
JC622_RS17345	COG4584	PFAM Integrase catalytic
JC622_RS17365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JC622_RS17385	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JC622_RS17400	COG3754	Rhamnan synthesis protein F
JC622_RS17405	COG0438	transferase activity, transferring glycosyl groups
JC622_RS17430	COG1091	dTDP-4-dehydrorhamnose reductase activity
JC622_RS17475	COG3328	transposase activity
JC622_RS17525	COG0471	metal ion transport
JC622_RS17525	COG0490	domain, Protein
JC622_RS17535	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
JC622_RS17555	COG0366	Alpha amylase catalytic
JC622_RS17560	COG1013	pyruvate-flavodoxin oxidoreductase activity
JC622_RS17560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JC622_RS17560	COG0674	pyruvate-flavodoxin oxidoreductase activity
JC622_RS17560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JC622_RS17570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JC622_RS17585	COG1012	belongs to the aldehyde dehydrogenase family
JC622_RS17595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JC622_RS17600	COG0512	Glutamine amidotransferase of anthranilate synthase
JC622_RS17610	COG0180	Tryptophanyl-tRNA synthetase
JC622_RS17620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JC622_RS17625	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JC622_RS17635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JC622_RS17640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JC622_RS17670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JC622_RS17675	COG0583	DNA-binding transcription factor activity
JC622_RS17695	COG0583	DNA-binding transcription factor activity
JC622_RS17705	COG0739	heme binding
JC622_RS17715	COG1511	domain protein
JC622_RS17715	COG3264	Mechanosensitive ion channel
JC622_RS17720	COG0584	glycerophosphoryl diester phosphodiesterase
JC622_RS17730	COG1053	succinate dehydrogenase
JC622_RS17735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JC622_RS17740	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JC622_RS17745	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JC622_RS17750	COG3366	ferrous iron transmembrane transporter activity
JC622_RS17755	COG0700	Nucleoside recognition
JC622_RS17760	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC622_RS17770	COG3214	Protein conserved in bacteria
JC622_RS17785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JC622_RS17800	COG1022	Amp-dependent synthetase and ligase
JC622_RS17810	COG4221	oxidoreductase activity
JC622_RS17825	COG0642	Histidine kinase
JC622_RS17835	COG0516	GMP reductase activity
JC622_RS17845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JC622_RS17855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JC622_RS17865	COG5002	protein histidine kinase activity
JC622_RS17865	COG5001	Diguanylate cyclase
JC622_RS17865	COG3447	MASE1 domain protein
JC622_RS17875	COG0583	DNA-binding transcription factor activity
JC622_RS17880	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JC622_RS17890	COG3069	C4-dicarboxylate transmembrane transporter activity
JC622_RS17905	COG0583	DNA-binding transcription factor activity
JC622_RS17910	COG3706	GGDEF domain
JC622_RS17920	COG1335	isochorismatase
JC622_RS17935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JC622_RS17940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JC622_RS17945	COG1702	phosphate starvation-inducible protein PhoH
JC622_RS17950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JC622_RS17955	COG4535	Mg2 and Co2 transporter CorC
JC622_RS17960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JC622_RS17965	COG0789	Transcriptional regulator
JC622_RS17980	COG1970	mechanosensitive ion channel activity
JC622_RS17985	COG4974	Belongs to the 'phage' integrase family
JC622_RS17990	COG0716	FMN binding
JC622_RS17995	COG0312	modulator of DNA gyrase
JC622_RS18000	COG0312	modulator of DNA gyrase
JC622_RS18005	COG2888	peptidyl-tyrosine sulfation
JC622_RS18010	COG0495	leucyl-tRNA aminoacylation
JC622_RS18025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JC622_RS18030	COG0799	negative regulation of ribosome biogenesis
JC622_RS18035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JC622_RS18040	COG0768	penicillin binding
JC622_RS18045	COG0772	Belongs to the SEDS family
JC622_RS18050	COG2951	lytic endotransglycosylase activity
JC622_RS18055	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JC622_RS18060	COG1686	Belongs to the peptidase S11 family
JC622_RS18065	COG2921	Belongs to the UPF0250 family
JC622_RS18070	COG0321	lipoyl(octanoyl) transferase activity
JC622_RS18075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JC622_RS18095	COG3139	Protein of unknown function (DUF1315)
JC622_RS18100	COG0252	asparaginase activity
JC622_RS18105	COG0786	glutamate:sodium symporter activity
JC622_RS18120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JC622_RS18125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JC622_RS18130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JC622_RS18145	COG3610	response to peptide
JC622_RS18150	COG2966	Psort location CytoplasmicMembrane, score
JC622_RS18160	COG0521	Mo-molybdopterin cofactor biosynthetic process
JC622_RS18175	COG2897	thiosulfate sulfurtransferase activity
JC622_RS18180	COG2066	Belongs to the glutaminase family
JC622_RS18185	COG3171	Protein conserved in bacteria
JC622_RS18190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JC622_RS18195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JC622_RS18200	COG2200	EAL domain
JC622_RS18205	COG1090	epimerase
JC622_RS18210	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JC622_RS18215	COG4181	ATPase activity
JC622_RS18220	COG2755	lipolytic protein G-D-S-L family
JC622_RS18225	COG0835	chemotaxis
JC622_RS18225	COG0784	Response regulator, receiver
JC622_RS18265	COG3397	chitin binding
JC622_RS18280	COG3706	GGDEF domain
JC622_RS18290	COG5002	protein histidine kinase activity
JC622_RS18290	COG2205	protein histidine kinase activity
JC622_RS18290	COG0784	Response regulator, receiver
JC622_RS18300	COG3655	Transcriptional regulator
JC622_RS18310	COG2814	Major facilitator Superfamily
JC622_RS18315	COG4771	TonB-dependent receptor
JC622_RS18335	COG0748	coenzyme F420 binding
JC622_RS18340	COG3721	Heme iron utilization protein
JC622_RS18350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC622_RS18365	COG3275	phosphorelay sensor kinase activity
JC622_RS18370	COG3279	Response regulator of the LytR AlgR family
JC622_RS18375	COG1966	Carbon starvation protein
JC622_RS18390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JC622_RS18405	COG1047	Peptidyl-prolyl cis-trans
JC622_RS18410	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
JC622_RS18420	COG0784	Response regulator, receiver
JC622_RS18420	COG0835	chemotaxis
JC622_RS18435	COG0429	hydrolase of the alpha beta-hydrolase fold
JC622_RS18440	COG2203	Gaf domain
JC622_RS18440	COG4251	negative regulation of phosphorylation
JC622_RS18440	COG5001	Diguanylate cyclase
JC622_RS18440	COG3706	GGDEF domain
JC622_RS18445	COG3089	Belongs to the UPF0270 family
JC622_RS18450	COG3954	Phosphoribulokinase
JC622_RS18465	COG1765	OsmC-like protein
JC622_RS18505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC622_RS18510	COG2313	pseudouridylate synthase activity
JC622_RS18535	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
JC622_RS18560	COG0569	domain protein
JC622_RS18560	COG2985	domain, Protein
JC622_RS18565	COG1272	protein, Hemolysin III
JC622_RS18570	COG0076	glutamate decarboxylase activity
JC622_RS18575	COG2917	probably involved in intracellular septation
JC622_RS18580	COG2350	Protein conserved in bacteria
JC622_RS18590	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JC622_RS18595	COG1381	Involved in DNA repair and RecF pathway recombination
JC622_RS18610	COG0681	Belongs to the peptidase S26 family
JC622_RS18615	COG0481	GTPase activity
JC622_RS18625	COG3026	antisigma factor binding
JC622_RS18630	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
JC622_RS18635	COG1595	DNA-templated transcription, initiation
JC622_RS18640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JC622_RS18650	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JC622_RS18655	COG0354	folic acid binding
JC622_RS18675	COG1324	tolerance protein
JC622_RS18695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JC622_RS18700	COG0191	fructose-bisphosphate aldolase activity
JC622_RS18705	COG0126	phosphoglycerate kinase activity
JC622_RS18710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JC622_RS18715	COG1940	carbohydrate kinase activity
JC622_RS18720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JC622_RS18725	COG2816	NAD+ diphosphatase activity
JC622_RS18735	COG4991	sh3 domain protein
JC622_RS18740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JC622_RS18750	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JC622_RS18760	COG3328	transposase activity
JC622_RS18785	COG4191	Histidine kinase
JC622_RS18835	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
JC622_RS18845	COG2199	diguanylate cyclase activity
JC622_RS18845	COG2203	Gaf domain
JC622_RS18850	COG0513	Belongs to the DEAD box helicase family
JC622_RS18880	COG0154	amidase activity
JC622_RS18885	COG2957	Belongs to the agmatine deiminase family
JC622_RS18900	COG1902	pentaerythritol trinitrate reductase activity
JC622_RS18915	COG1238	metal cluster binding
JC622_RS18920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JC622_RS18925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JC622_RS18930	COG0585	pseudouridine synthase activity
JC622_RS18940	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JC622_RS18945	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JC622_RS18950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC622_RS18960	COG1376	ErfK ybiS ycfS ynhG family protein
JC622_RS18965	COG0668	transmembrane transport
JC622_RS18975	COG2731	YhcH YjgK YiaL family protein
JC622_RS18985	COG1794	racemase activity, acting on amino acids and derivatives
JC622_RS19000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JC622_RS19015	COG0517	IMP dehydrogenase activity
JC622_RS19015	COG0617	tRNA 3'-terminal CCA addition
JC622_RS19015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JC622_RS19020	COG0488	(ABC) transporter
JC622_RS19030	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JC622_RS19070	COG0148	phosphopyruvate hydratase activity
JC622_RS19075	COG0504	CTP synthase activity
JC622_RS19080	COG3956	TIGRFAM MazG family protein
JC622_RS19085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JC622_RS19090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JC622_RS19100	COG4807	Protein conserved in bacteria
JC622_RS19105	COG3023	N-Acetylmuramoyl-L-alanine amidase
JC622_RS19110	COG0783	Belongs to the Dps family
JC622_RS19115	COG1151	hydroxylamine reductase activity
JC622_RS19120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JC622_RS19125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JC622_RS19130	COG0671	phosphoesterase, PA-phosphatase related
JC622_RS19135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JC622_RS19140	COG0163	prenyltransferase activity
JC622_RS19155	COG1131	(ABC) transporter
JC622_RS19160	COG0842	Transport permease protein
JC622_RS19190	COG1823	symporter activity
JC622_RS19200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JC622_RS19205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JC622_RS19210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JC622_RS19220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JC622_RS19225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JC622_RS19230	COG1489	DNA binding
JC622_RS19240	COG1643	Atp-dependent helicase
JC622_RS19245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JC622_RS19250	COG0346	lactoylglutathione lyase activity
JC622_RS19255	COG2076	Multidrug Resistance protein
JC622_RS19260	COG2076	Multidrug Resistance protein
JC622_RS19270	COG0784	Response regulator, receiver
JC622_RS19270	COG3437	response regulator, receiver
JC622_RS19275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JC622_RS19290	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JC622_RS19305	COG1136	(ABC) transporter
JC622_RS19325	COG0840	transmembrane signaling receptor activity
JC622_RS19345	COG0529	Catalyzes the synthesis of activated sulfate
JC622_RS19350	COG0471	metal ion transport
JC622_RS19350	COG3273	potassium ion transport
JC622_RS19355	COG2895	sulfate adenylyltransferase (ATP) activity
JC622_RS19360	COG0175	sulfate reduction
JC622_RS19365	COG1648	precorrin-2 dehydrogenase activity
JC622_RS19365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JC622_RS19370	COG0330	HflC and HflK could
JC622_RS19375	COG1585	Membrane protein implicated in regulation of membrane protease activity
JC622_RS19380	COG0840	transmembrane signaling receptor activity
JC622_RS19385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JC622_RS19395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JC622_RS19400	COG1640	4-alpha-glucanotransferase
JC622_RS19405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JC622_RS19455	COG0561	phosphatase activity
JC622_RS19470	COG0733	neurotransmitter:sodium symporter activity
JC622_RS19480	COG0733	neurotransmitter:sodium symporter activity
JC622_RS19545	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JC622_RS19550	COG2885	chlorophyll binding
JC622_RS19555	COG0823	Involved in the tonB-independent uptake of proteins
JC622_RS19570	COG0811	peptide transport
JC622_RS19575	COG0824	Thioesterase
JC622_RS19580	COG3790	cyd operon protein YbgE
JC622_RS19585	COG4890	Cyd operon protein YbgT
JC622_RS19590	COG1294	oxidase, subunit
JC622_RS19600	COG2255	four-way junction helicase activity
JC622_RS19605	COG0632	four-way junction helicase activity
JC622_RS19610	COG0840	transmembrane signaling receptor activity
JC622_RS19635	COG3916	Acyl-homoserine-lactone synthase
JC622_RS19645	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
JC622_RS19650	COG3706	GGDEF domain
JC622_RS19650	COG2203	Gaf domain
JC622_RS19650	COG5001	Diguanylate cyclase
JC622_RS19650	COG4251	negative regulation of phosphorylation
JC622_RS19660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JC622_RS19670	COG2995	paraquat-inducible protein a
JC622_RS19675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JC622_RS19675	COG3008	intermembrane lipid transfer
JC622_RS19685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JC622_RS19690	COG0442	prolyl-tRNA aminoacylation
JC622_RS19695	COG4221	oxidoreductase activity
JC622_RS19710	COG1024	Enoyl-CoA hydratase
JC622_RS19720	COG0110	maltose O-acetyltransferase activity
JC622_RS19730	COG4166	transmembrane transport
JC622_RS19740	COG0840	transmembrane signaling receptor activity
JC622_RS19745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JC622_RS19750	COG0735	belongs to the Fur family
JC622_RS19775	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JC622_RS19780	COG0513	Belongs to the DEAD box helicase family
JC622_RS19785	COG2153	protein acetylation
JC622_RS19795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JC622_RS19800	COG0557	exoribonuclease II activity
JC622_RS19805	COG3706	GGDEF domain
JC622_RS19810	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
JC622_RS19810	COG2885	chlorophyll binding
JC622_RS19815	COG3240	lipase activity
JC622_RS19820	COG3111	PFAM Bacterial OB fold (BOF) protein
JC622_RS19830	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JC622_RS19835	COG1194	a g-specific adenine glycosylase
JC622_RS19840	COG0617	tRNA 3'-terminal CCA addition
JC622_RS19860	COG3068	Protein conserved in bacteria
JC622_RS19870	COG0739	heme binding
JC622_RS19890	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JC622_RS19895	COG1121	(ABC) transporter
JC622_RS19900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JC622_RS19905	COG0583	DNA-binding transcription factor activity
JC622_RS19915	COG1573	uracil-dna glycosylase
JC622_RS19920	COG2962	Rard protein
JC622_RS19930	COG2827	Endonuclease containing a URI domain
JC622_RS19945	COG1842	Phage shock protein A
JC622_RS19950	COG0204	Acyl-transferase
JC622_RS19970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC622_RS19975	COG0583	DNA-binding transcription factor activity
JC622_RS20010	COG3104	oligopeptide transport
JC622_RS20020	COG0583	DNA-binding transcription factor activity
JC622_RS20040	COG3150	esterase
JC622_RS20050	COG3151	Protein conserved in bacteria
JC622_RS20055	COG0494	nUDIX hydrolase
JC622_RS20060	COG1538	Outer membrane efflux protein
JC622_RS20065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JC622_RS20065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JC622_RS20070	COG1560	Kdo2-lipid A biosynthetic process
JC622_RS20075	COG2213	PTS system mannitol-specific
JC622_RS20075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS20080	COG0246	Mannitol dehydrogenase
JC622_RS20085	COG3722	fumarate hydratase activity
JC622_RS20115	COG1671	Belongs to the UPF0178 family
JC622_RS20120	COG1988	membrane-bound metal-dependent
JC622_RS20125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC622_RS20130	COG0513	Belongs to the DEAD box helicase family
JC622_RS20155	COG1575	Belongs to the MenA family. Type 1 subfamily
JC622_RS20160	COG1169	isochorismate synthase
JC622_RS20165	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JC622_RS20170	COG0596	Alpha beta hydrolase
JC622_RS20175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JC622_RS20180	COG1441	menaquinone biosynthetic process
JC622_RS20185	COG0318	PFAM AMP-dependent synthetase and ligase
JC622_RS20190	COG3291	Pkd domain containing protein
JC622_RS20195	COG2949	membrane
JC622_RS20200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JC622_RS20210	COG0784	Response regulator, receiver
JC622_RS20210	COG0835	chemotaxis
JC622_RS20220	COG1444	tRNA N-acetyltransferase activity
JC622_RS20240	COG1803	Methylglyoxal synthase
JC622_RS20245	COG1979	alcohol dehydrogenase
JC622_RS20260	COG4221	oxidoreductase activity
JC622_RS20300	COG1368	sulfuric ester hydrolase activity
JC622_RS20305	COG1522	sequence-specific DNA binding
JC622_RS20315	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JC622_RS20325	COG1546	Belongs to the CinA family
JC622_RS20325	COG1058	Belongs to the CinA family
JC622_RS20335	COG0561	phosphatase activity
JC622_RS20345	COG2926	Belongs to the UPF0265 family
JC622_RS20385	COG1396	sequence-specific DNA binding
JC622_RS20390	COG3135	benzoate transporter
JC622_RS20415	COG0840	transmembrane signaling receptor activity
JC622_RS20420	COG3047	cAMP biosynthetic process
JC622_RS20425	COG2199	diguanylate cyclase activity
JC622_RS20430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JC622_RS20465	COG2197	response regulator
JC622_RS20500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JC622_RS20535	COG1396	sequence-specific DNA binding
JC622_RS20545	COG3328	transposase activity
JC622_RS20560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JC622_RS20570	COG1278	Cold shock
JC622_RS20575	COG2252	PERMEase
JC622_RS20580	COG2376	Dihydroxyacetone kinase
JC622_RS20585	COG1461	Dihydroxyacetone kinase
JC622_RS20590	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JC622_RS20590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS20590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JC622_RS20600	COG3284	Transcriptional regulator
JC622_RS20605	COG3385	transposase activity
JC622_RS20615	COG0628	permease
JC622_RS20620	COG0671	phosphoesterase, PA-phosphatase related
JC622_RS20635	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JC622_RS20640	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JC622_RS20660	COG0456	acetyltransferase
JC622_RS20665	COG3133	Outer membrane lipoprotein
JC622_RS20670	COG0004	ammonium transporteR
JC622_RS20675	COG3706	GGDEF domain
JC622_RS20685	COG3932	Exopolysaccharide synthesis, ExoD
JC622_RS20690	COG0814	amino acid
JC622_RS20695	COG3706	GGDEF domain
JC622_RS20705	COG0110	maltose O-acetyltransferase activity
JC622_RS20710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JC622_RS20720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JC622_RS20725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JC622_RS20735	COG0137	argininosuccinate synthase activity
JC622_RS20740	COG0165	Argininosuccinate lyase
JC622_RS20755	COG3314	Sporulation integral membrane protein YlbJ
JC622_RS20780	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JC622_RS20785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JC622_RS20800	COG0477	Major facilitator Superfamily
JC622_RS20825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JC622_RS20830	COG0523	cobalamin synthesis protein
JC622_RS20840	COG2200	EAL domain
JC622_RS20845	COG1049	propionate catabolic process, 2-methylcitrate cycle
JC622_RS20850	COG1752	Esterase of the alpha-beta hydrolase superfamily
JC622_RS20855	COG0840	transmembrane signaling receptor activity
JC622_RS20865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JC622_RS20870	COG0508	dehydrogenase complex catalyzes the overall conversion of
JC622_RS20875	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JC622_RS20880	COG2186	Transcriptional regulator
JC622_RS20905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JC622_RS20910	COG1459	type II secretion system
JC622_RS20925	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
JC622_RS20930	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JC622_RS20935	COG0494	nUDIX hydrolase
JC622_RS20940	COG0653	protein targeting
JC622_RS20950	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JC622_RS20955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JC622_RS20960	COG0849	cell division
JC622_RS20970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JC622_RS20975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JC622_RS20980	COG0772	Belongs to the SEDS family
JC622_RS20985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JC622_RS20990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JC622_RS20995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JC622_RS21005	COG0768	penicillin binding
JC622_RS21010	COG3116	cell division
JC622_RS21015	COG0275	rRNA processing
JC622_RS21020	COG2001	Belongs to the MraZ family
JC622_RS21030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JC622_RS21035	COG3107	peptidoglycan biosynthetic process
JC622_RS21040	COG0792	nuclease activity
JC622_RS21045	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JC622_RS21050	COG2823	Periplasmic or secreted lipoprotein
JC622_RS21055	COG2969	positive regulation of protein catabolic process
JC622_RS21060	COG0625	glutathione transferase activity
JC622_RS21065	COG2857	Cytochrome c1
JC622_RS21070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JC622_RS21075	COG0723	plastoquinol--plastocyanin reductase activity
JC622_RS21080	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JC622_RS21085	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JC622_RS21090	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JC622_RS21100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JC622_RS21105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JC622_RS21135	COG3964	amidohydrolase
JC622_RS21150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS21150	COG3711	transcriptional antiterminator
JC622_RS21155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS21160	COG1660	Displays ATPase and GTPase activities
JC622_RS21165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC622_RS21180	COG1137	ATPase activity
JC622_RS21185	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JC622_RS21190	COG3117	lipopolysaccharide transmembrane transporter activity
JC622_RS21195	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JC622_RS21200	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JC622_RS21200	COG0517	IMP dehydrogenase activity
JC622_RS21205	COG1127	ABC transporter
JC622_RS21210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JC622_RS21215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JC622_RS21220	COG2854	intermembrane phospholipid transfer
JC622_RS21230	COG5007	Belongs to the BolA IbaG family
JC622_RS21235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JC622_RS21240	COG0312	modulator of DNA gyrase
JC622_RS21245	COG3028	Belongs to the UPF0307 family
JC622_RS21250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JC622_RS21270	COG1011	Hydrolase
JC622_RS21285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JC622_RS21290	COG0019	diaminopimelate decarboxylase activity
JC622_RS21300	COG1965	Belongs to the frataxin family
JC622_RS21305	COG0400	carboxylic ester hydrolase activity
JC622_RS21310	COG3072	Adenylate cyclase
JC622_RS21315	COG0181	hydroxymethylbilane synthase activity
JC622_RS21325	COG2959	enzyme of heme biosynthesis
JC622_RS21340	COG1494	fructose-1,6-bisphosphatase
JC622_RS21395	COG0795	lipopolysaccharide-transporting ATPase activity
JC622_RS21400	COG0795	lipopolysaccharide-transporting ATPase activity
JC622_RS21405	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JC622_RS21410	COG2927	DNA polymerase III (CHI subunit)
JC622_RS21435	COG1247	-acetyltransferase
JC622_RS21440	COG0753	catalase activity
JC622_RS21465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JC622_RS21470	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JC622_RS21475	COG5380	lipid catabolic process
JC622_RS21495	COG4533	DNA binding
JC622_RS21505	COG2873	o-acetylhomoserine
JC622_RS21535	COG3842	ATPase activity
JC622_RS21545	COG1175	transmembrane transport
JC622_RS21600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JC622_RS21605	COG1074	ATP-dependent DNA helicase activity
JC622_RS21610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JC622_RS21615	COG2259	Doxx family
JC622_RS21620	COG1741	Belongs to the pirin family
JC622_RS21630	COG0583	DNA-binding transcription factor activity
JC622_RS21660	COG3706	GGDEF domain
JC622_RS21665	COG4771	TonB-dependent receptor
JC622_RS21705	COG0203	ribosomal protein L17
JC622_RS21710	COG0202	RNA polymerase activity
JC622_RS21715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JC622_RS21720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JC622_RS21725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JC622_RS21730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JC622_RS21735	COG0201	protein transport
JC622_RS21740	COG0200	Binds to the 23S rRNA
JC622_RS21745	COG1841	ribosomal large subunit assembly
JC622_RS21750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JC622_RS21755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JC622_RS21760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JC622_RS21765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JC622_RS21770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JC622_RS21775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JC622_RS21780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JC622_RS21785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JC622_RS21790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JC622_RS21795	COG0255	Belongs to the universal ribosomal protein uL29 family
JC622_RS21800	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JC622_RS21805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JC622_RS21810	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JC622_RS21815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JC622_RS21820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JC622_RS21825	COG0089	rRNA binding
JC622_RS21830	COG0088	Forms part of the polypeptide exit tunnel
JC622_RS21835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JC622_RS21840	COG0051	transcription antitermination factor activity, RNA binding
JC622_RS21860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JC622_RS21865	COG2183	response to ionizing radiation
JC622_RS21885	COG0596	Alpha beta hydrolase
JC622_RS21890	COG1040	competence protein
JC622_RS21895	COG0316	Belongs to the HesB IscA family
JC622_RS21895	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JC622_RS21900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JC622_RS21905	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JC622_RS21910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JC622_RS21915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JC622_RS21920	COG4942	peptidase
JC622_RS21930	COG1609	Transcriptional regulator
JC622_RS21935	COG0800	Aldolase
JC622_RS21940	COG0129	dihydroxy-acid dehydratase activity
JC622_RS21945	COG3265	gluconokinase activity
JC622_RS21950	COG2610	gluconate transmembrane transporter activity
JC622_RS21955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JC622_RS21960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JC622_RS21970	COG0456	acetyltransferase
JC622_RS21975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JC622_RS21980	COG1490	D-aminoacyl-tRNA deacylase activity
JC622_RS21985	COG1295	ribonuclease BN
JC622_RS21990	COG0281	malic enzyme
JC622_RS21995	COG0814	amino acid
JC622_RS22000	COG0702	epimerase
JC622_RS22010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JC622_RS22015	COG0254	rRNA binding
JC622_RS22030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JC622_RS22035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JC622_RS22045	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JC622_RS22055	COG0514	ATP-dependent DNA helicase (RecQ)
JC622_RS22060	COG2050	protein possibly involved in aromatic compounds catabolism
JC622_RS22075	COG2258	MOSC domain
JC622_RS22080	COG1177	transmembrane transport
JC622_RS22085	COG1176	ABC-type spermidine putrescine transport system, permease component I
JC622_RS22090	COG3842	ATPase activity
JC622_RS22110	COG0174	glutamine synthetase
JC622_RS22130	COG3045	CreA protein
JC622_RS22135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JC622_RS22140	COG0443	Heat shock 70 kDa protein
JC622_RS22155	COG0366	Alpha amylase catalytic
JC622_RS22165	COG4310	Domain of unknown function (DUF2172)
JC622_RS22200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JC622_RS22210	COG4211	Belongs to the binding-protein-dependent transport system permease family
JC622_RS22215	COG1129	ABC transporter
JC622_RS22225	COG3250	beta-galactosidase activity
JC622_RS22230	COG1609	Transcriptional regulator
JC622_RS22235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JC622_RS22240	COG1085	galactose-1-phosphate uridylyltransferase
JC622_RS22245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JC622_RS22250	COG2017	converts alpha-aldose to the beta-anomer
JC622_RS22255	COG1968	undecaprenyl-diphosphatase activity
JC622_RS22265	COG1595	DNA-templated transcription, initiation
JC622_RS22275	COG0018	arginyl-trna synthetase
JC622_RS22285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JC622_RS22290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JC622_RS22300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JC622_RS22305	COG1131	(ABC) transporter
JC622_RS22310	COG0842	Transport permease protein
JC622_RS22315	COG0842	Transport permease protein
JC622_RS22320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JC622_RS22335	COG2116	formate transmembrane transporter activity
JC622_RS22340	COG1648	precorrin-2 dehydrogenase activity
JC622_RS22340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JC622_RS22345	COG2239	Acts as a magnesium transporter
JC622_RS22355	COG0737	Belongs to the 5'-nucleotidase family
JC622_RS22360	COG1079	Belongs to the binding-protein-dependent transport system permease family
JC622_RS22365	COG4603	Belongs to the binding-protein-dependent transport system permease family
JC622_RS22370	COG3845	ABC transporter
JC622_RS22375	COG1744	ABC transporter substrate-binding protein PnrA-like
JC622_RS22380	COG0210	DNA helicase
JC622_RS22455	COG1280	lysine exporter protein (LysE YggA)
JC622_RS22485	COG1216	Glycosyl transferase, family 2
JC622_RS22500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC622_RS22515	COG1063	alcohol dehydrogenase
JC622_RS22520	COG3245	cytochrome
JC622_RS22535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JC622_RS22540	COG2166	iron-sulfur cluster assembly
JC622_RS22545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JC622_RS22575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JC622_RS22585	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JC622_RS22590	COG3074	FtsZ-dependent cytokinesis
JC622_RS22600	COG1045	serine acetyltransferase
JC622_RS22610	COG0745	RESPONSE REGULATOR receiver
JC622_RS22615	COG2205	protein histidine kinase activity
JC622_RS22620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JC622_RS22625	COG0534	Mate efflux family protein
JC622_RS22640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JC622_RS22645	COG2937	Belongs to the GPAT DAPAT family
JC622_RS22650	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JC622_RS22655	COG3161	chorismate lyase activity
JC622_RS22675	COG0604	alcohol dehydrogenase
JC622_RS22680	COG1519	Transferase
JC622_RS22685	COG0859	PFAM glycosyl transferase family 9
JC622_RS22690	COG0463	Glycosyl transferase, family 2
JC622_RS22695	COG0859	PFAM glycosyl transferase family 9
JC622_RS22700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JC622_RS22705	COG2990	Protein conserved in bacteria
JC622_RS22710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JC622_RS22720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JC622_RS22725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JC622_RS22730	COG2003	Belongs to the UPF0758 family
JC622_RS22735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JC622_RS22740	COG0756	dUTP diphosphatase activity
JC622_RS22745	COG1309	transcriptional regulator
JC622_RS22750	COG0668	transmembrane transport
JC622_RS22755	COG0166	Belongs to the GPI family
JC622_RS22760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JC622_RS22780	COG0045	succinate-CoA ligase (ADP-forming) activity
JC622_RS22780	COG1042	CoA-binding domain protein
JC622_RS22780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JC622_RS22810	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
JC622_RS22815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JC622_RS22820	COG1739	Uncharacterized protein family UPF0029
JC622_RS22825	COG0006	proline dipeptidase activity
JC622_RS22830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JC622_RS22835	COG1024	Enoyl-CoA hydratase
JC622_RS22835	COG1250	3-hydroxyacyl-CoA dehydrogenase
JC622_RS22840	COG0183	Belongs to the thiolase family
JC622_RS22865	COG0425	Belongs to the sulfur carrier protein TusA family
JC622_RS22870	COG0251	oxidation-reduction process
JC622_RS22875	COG2885	chlorophyll binding
JC622_RS22880	COG2818	Glycosylase
JC622_RS22885	COG0752	glycyl-tRNA synthetase alpha subunit
JC622_RS22890	COG0751	glycine-tRNA ligase activity
JC622_RS22900	COG2199	diguanylate cyclase activity
JC622_RS22900	COG2200	EAL domain
JC622_RS22900	COG2202	Pas domain
JC622_RS22930	COG1609	Transcriptional regulator
JC622_RS22960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JC622_RS22970	COG2960	long-chain fatty acid transporting porin activity
JC622_RS22975	COG5001	Diguanylate cyclase
JC622_RS22985	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JC622_RS23000	COG3118	belongs to the thioredoxin family
JC622_RS23005	COG0513	Belongs to the DEAD box helicase family
JC622_RS23010	COG0248	Ppx GppA phosphatase
JC622_RS23020	COG0742	ribosomal rna small subunit methyltransferase
JC622_RS23035	COG3469	chitinase activity
JC622_RS23040	COG3397	chitin binding
JC622_RS23050	COG0084	hydrolase, TatD family'
JC622_RS23055	COG0805	protein transport
JC622_RS23060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JC622_RS23065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JC622_RS23070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JC622_RS23075	COG3165	ubiquinone biosynthetic process from chorismate
JC622_RS23080	COG2226	methyltransferase
JC622_RS23085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JC622_RS23090	COG0402	S-adenosylhomocysteine deaminase activity
JC622_RS23095	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JC622_RS23130	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JC622_RS23135	COG0848	biopolymer transport protein
JC622_RS23140	COG0811	peptide transport
JC622_RS23145	COG0811	peptide transport
JC622_RS23155	COG2771	luxR family
JC622_RS23200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JC622_RS23205	COG1349	DNA-binding transcription factor activity
JC622_RS23210	COG0745	RESPONSE REGULATOR receiver
JC622_RS23215	COG2205	protein histidine kinase activity
JC622_RS23230	COG4452	Inner membrane protein CreD
JC622_RS23245	COG0297	glycogen (starch) synthase activity
JC622_RS23245	COG0438	transferase activity, transferring glycosyl groups
JC622_RS23290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JC622_RS23295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JC622_RS23300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JC622_RS23305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JC622_RS23310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JC622_RS23315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JC622_RS23320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JC622_RS23325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JC622_RS23335	COG0356	it plays a direct role in the translocation of protons across the membrane
JC622_RS23345	COG1475	DNA binding
JC622_RS23350	COG1192	Involved in chromosome partitioning
JC622_RS23355	COG0357	Ribosomal RNA small subunit methyltransferase G
JC622_RS23360	COG0445	tRNA wobble uridine modification
JC622_RS23365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JC622_RS23375	COG4615	Cyclic peptide transporter
JC622_RS23380	COG1120	ATPase activity
JC622_RS23385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC622_RS23390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC622_RS23395	COG3550	peptidyl-serine autophosphorylation
JC622_RS23445	COG0732	type I restriction modification DNA specificity domain
JC622_RS23490	COG4974	Belongs to the 'phage' integrase family
JC622_RS23495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JC622_RS23500	COG0706	membrane insertase activity
JC622_RS23505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JC622_RS23510	COG0594	ribonuclease P activity
JC622_RS23515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JC622_RS23520	COG1126	abc transporter atp-binding protein