locus-tag	class	description
LEO77_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LEO77_RS00010	COG0592	DNA-directed DNA polymerase activity
LEO77_RS00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LEO77_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO77_RS00050	COG0071	Belongs to the small heat shock protein (HSP20) family
LEO77_RS00055	COG3977	Valine--pyruvate aminotransferase
LEO77_RS00070	COG2814	Major facilitator Superfamily
LEO77_RS00075	COG0745	RESPONSE REGULATOR receiver
LEO77_RS00080	COG2205	protein histidine kinase activity
LEO77_RS00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEO77_RS00105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO77_RS00105	COG4191	Histidine kinase
LEO77_RS00110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO77_RS00115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO77_RS00120	COG1309	transcriptional regulator
LEO77_RS00150	COG0561	phosphatase activity
LEO77_RS00155	COG2267	carboxylic ester hydrolase activity
LEO77_RS00165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEO77_RS00170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEO77_RS00175	COG1758	RNA polymerase activity
LEO77_RS00180	COG0194	GDP metabolic process
LEO77_RS00185	COG0859	PFAM glycosyl transferase family 9
LEO77_RS00190	COG3642	lipopolysaccharide core region biosynthetic process
LEO77_RS00230	COG0589	response to stress
LEO77_RS00235	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEO77_RS00240	COG1528	Iron-storage protein
LEO77_RS00245	COG2081	HI0933 family
LEO77_RS00260	COG3539	Fimbrial protein
LEO77_RS00265	COG3121	Chaperone
LEO77_RS00270	COG3188	usher protein
LEO77_RS00280	COG3275	phosphorelay sensor kinase activity
LEO77_RS00285	COG3279	Response regulator of the LytR AlgR family
LEO77_RS00290	COG2223	nitrite transmembrane transporter activity
LEO77_RS00295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LEO77_RS00300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LEO77_RS00315	COG0583	DNA-binding transcription factor activity
LEO77_RS00325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LEO77_RS00380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LEO77_RS00385	COG0166	Belongs to the GPI family
LEO77_RS00390	COG0668	transmembrane transport
LEO77_RS00395	COG1309	transcriptional regulator
LEO77_RS00400	COG0756	dUTP diphosphatase activity
LEO77_RS00405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LEO77_RS00410	COG2003	Belongs to the UPF0758 family
LEO77_RS00415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LEO77_RS00420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LEO77_RS00430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LEO77_RS00435	COG2990	Protein conserved in bacteria
LEO77_RS00440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LEO77_RS00445	COG0859	PFAM glycosyl transferase family 9
LEO77_RS00450	COG0463	Glycosyl transferase, family 2
LEO77_RS00455	COG0859	PFAM glycosyl transferase family 9
LEO77_RS00460	COG1519	Transferase
LEO77_RS00475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO77_RS00480	COG1609	Transcriptional regulator
LEO77_RS00485	COG0604	alcohol dehydrogenase
LEO77_RS00510	COG3161	chorismate lyase activity
LEO77_RS00515	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LEO77_RS00520	COG2937	Belongs to the GPAT DAPAT family
LEO77_RS00525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LEO77_RS00540	COG0534	Mate efflux family protein
LEO77_RS00545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LEO77_RS00550	COG2205	protein histidine kinase activity
LEO77_RS00555	COG0745	RESPONSE REGULATOR receiver
LEO77_RS00565	COG1045	serine acetyltransferase
LEO77_RS00575	COG3074	FtsZ-dependent cytokinesis
LEO77_RS00580	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LEO77_RS00585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO77_RS00585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO77_RS00590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LEO77_RS00630	COG1609	Transcriptional regulator
LEO77_RS00635	COG3250	beta-galactosidase activity
LEO77_RS00640	COG2731	YhcH YjgK YiaL family protein
LEO77_RS00645	COG0531	amino acid
LEO77_RS00650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO77_RS00655	COG0531	amino acid
LEO77_RS00660	COG0385	Bile acid
LEO77_RS00665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LEO77_RS00685	COG0583	DNA-binding transcription factor activity
LEO77_RS00690	COG1561	YicC-like family, N-terminal region
LEO77_RS00695	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LEO77_RS00700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LEO77_RS00715	COG5001	Diguanylate cyclase
LEO77_RS00715	COG4251	negative regulation of phosphorylation
LEO77_RS00715	COG2203	Gaf domain
LEO77_RS00715	COG3706	GGDEF domain
LEO77_RS00720	COG3084	Protein conserved in bacteria
LEO77_RS00730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LEO77_RS00735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEO77_RS00745	COG1335	isochorismatase
LEO77_RS00755	COG1683	Conserved Protein
LEO77_RS00760	COG0204	Acyl-transferase
LEO77_RS00765	COG0204	Acyl-transferase
LEO77_RS00770	COG0606	chelatase, subunit chli
LEO77_RS00780	COG3978	acetolactate synthase activity
LEO77_RS00790	COG0129	dihydroxy-acid dehydratase activity
LEO77_RS00805	COG1309	transcriptional regulator
LEO77_RS00820	COG2391	methyltransferase activity
LEO77_RS00825	COG2962	Rard protein
LEO77_RS00830	COG1012	belongs to the aldehyde dehydrogenase family
LEO77_RS00835	COG1396	sequence-specific DNA binding
LEO77_RS00840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LEO77_RS00850	COG0519	Catalyzes the synthesis of GMP from XMP
LEO77_RS00850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEO77_RS00860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO77_RS00890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LEO77_RS00895	COG2204	response regulator
LEO77_RS00910	COG0174	glutamine synthetase
LEO77_RS00915	COG1217	gtp-binding protein TYPA
LEO77_RS00920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO77_RS00925	COG0569	domain protein
LEO77_RS00930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO77_RS00930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO77_RS00935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEO77_RS00940	COG0242	peptide deformylase activity
LEO77_RS00945	COG1652	LysM domain
LEO77_RS00950	COG0758	DNA mediated transformation
LEO77_RS00955	COG2922	Belongs to the Smg family
LEO77_RS00960	COG0551	DNA topoisomerase type I activity
LEO77_RS00970	COG0009	L-threonylcarbamoyladenylate synthase
LEO77_RS00975	COG0408	coproporphyrinogen oxidase activity
LEO77_RS00980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LEO77_RS00990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LEO77_RS01000	COG3078	GTPase activator activity
LEO77_RS01010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEO77_RS01040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LEO77_RS01045	COG1288	antiporter activity
LEO77_RS01050	COG1438	arginine binding
LEO77_RS01055	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LEO77_RS01060	COG0540	Belongs to the ATCase OTCase family
LEO77_RS01080	COG0583	DNA-binding transcription factor activity
LEO77_RS01100	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LEO77_RS01120	COG2207	Transcriptional regulator
LEO77_RS01125	COG1979	alcohol dehydrogenase
LEO77_RS01130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LEO77_RS01135	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LEO77_RS01145	COG3681	Belongs to the UPF0597 family
LEO77_RS01155	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO77_RS01160	COG2076	Multidrug Resistance protein
LEO77_RS01165	COG2076	Multidrug Resistance protein
LEO77_RS01170	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LEO77_RS01175	COG0726	polysaccharide deacetylase
LEO77_RS01180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LEO77_RS01180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO77_RS01185	COG0463	Glycosyl transferase, family 2
LEO77_RS01190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO77_RS01205	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO77_RS01210	COG0564	pseudouridine synthase activity
LEO77_RS01220	COG0542	response to heat
LEO77_RS01225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LEO77_RS01230	COG2502	aspartate--ammonia ligase
LEO77_RS01235	COG1522	sequence-specific DNA binding
LEO77_RS01245	COG5413	integral membrane protein
LEO77_RS01250	COG0517	IMP dehydrogenase activity
LEO77_RS01250	COG0516	GMP reductase activity
LEO77_RS01255	COG1028	Short-chain dehydrogenase reductase Sdr
LEO77_RS01270	COG2205	protein histidine kinase activity
LEO77_RS01280	COG2204	response regulator
LEO77_RS01325	COG0243	molybdopterin cofactor binding
LEO77_RS01330	COG3005	denitrification pathway
LEO77_RS01335	COG4191	Histidine kinase
LEO77_RS01335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO77_RS01365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO77_RS01370	COG0569	domain protein
LEO77_RS01375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LEO77_RS01400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEO77_RS01415	COG0250	Participates in transcription elongation, termination and antitermination
LEO77_RS01420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LEO77_RS01425	COG0081	regulation of translation
LEO77_RS01430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LEO77_RS01435	COG0222	ribosome binding
LEO77_RS01440	COG0085	RNA polymerase activity
LEO77_RS01445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LEO77_RS01450	COG2964	Protein conserved in bacteria
LEO77_RS01460	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LEO77_RS01465	COG2923	Belongs to the DsrF TusC family
LEO77_RS01470	COG2168	tRNA wobble position uridine thiolation
LEO77_RS01475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LEO77_RS01480	COG0049	tRNA binding
LEO77_RS01485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LEO77_RS01490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LEO77_RS01495	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEO77_RS01550	COG3714	YhhN family
LEO77_RS01575	COG1301	dicarboxylic acid transport
LEO77_RS01585	COG2095	MarC family integral membrane protein
LEO77_RS01595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO77_RS01605	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LEO77_RS01615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO77_RS01620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LEO77_RS01625	COG5007	Belongs to the BolA IbaG family
LEO77_RS01635	COG2854	intermembrane phospholipid transfer
LEO77_RS01640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LEO77_RS01645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LEO77_RS01650	COG1127	ABC transporter
LEO77_RS01655	COG0517	IMP dehydrogenase activity
LEO77_RS01655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LEO77_RS01660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LEO77_RS01665	COG3117	lipopolysaccharide transmembrane transporter activity
LEO77_RS01670	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LEO77_RS01675	COG1137	ATPase activity
LEO77_RS01690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO77_RS01695	COG1660	Displays ATPase and GTPase activities
LEO77_RS01700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO77_RS01705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEO77_RS01710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LEO77_RS01720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LEO77_RS01725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LEO77_RS01730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LEO77_RS01735	COG0723	plastoquinol--plastocyanin reductase activity
LEO77_RS01740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LEO77_RS01745	COG2857	Cytochrome c1
LEO77_RS01750	COG0625	glutathione transferase activity
LEO77_RS01755	COG2969	positive regulation of protein catabolic process
LEO77_RS01760	COG2823	Periplasmic or secreted lipoprotein
LEO77_RS01765	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LEO77_RS01770	COG0792	nuclease activity
LEO77_RS01775	COG3107	peptidoglycan biosynthetic process
LEO77_RS01780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LEO77_RS01790	COG2001	Belongs to the MraZ family
LEO77_RS01795	COG0275	rRNA processing
LEO77_RS01800	COG3116	cell division
LEO77_RS01805	COG0768	penicillin binding
LEO77_RS01815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LEO77_RS01820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEO77_RS01825	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LEO77_RS01830	COG0772	Belongs to the SEDS family
LEO77_RS01835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LEO77_RS01840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEO77_RS01850	COG0849	cell division
LEO77_RS01855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LEO77_RS01860	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LEO77_RS01870	COG0653	protein targeting
LEO77_RS01875	COG0494	nUDIX hydrolase
LEO77_RS01880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LEO77_RS01885	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LEO77_RS01900	COG1459	type II secretion system
LEO77_RS01905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO77_RS01930	COG2186	Transcriptional regulator
LEO77_RS01935	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LEO77_RS01940	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEO77_RS01945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LEO77_RS01955	COG0840	transmembrane signaling receptor activity
LEO77_RS01960	COG1752	Esterase of the alpha-beta hydrolase superfamily
LEO77_RS01965	COG1049	propionate catabolic process, 2-methylcitrate cycle
LEO77_RS01975	COG2200	EAL domain
LEO77_RS01985	COG0523	cobalamin synthesis protein
LEO77_RS01990	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO77_RS02005	COG0477	Major facilitator Superfamily
LEO77_RS02020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LEO77_RS02025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LEO77_RS02050	COG3314	Sporulation integral membrane protein YlbJ
LEO77_RS02065	COG0165	Argininosuccinate lyase
LEO77_RS02070	COG0137	argininosuccinate synthase activity
LEO77_RS02080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEO77_RS02085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LEO77_RS02095	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LEO77_RS02100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LEO77_RS02120	COG0583	DNA-binding transcription factor activity
LEO77_RS02125	COG1380	Effector of murein hydrolase LrgA
LEO77_RS02130	COG1346	cytolysis
LEO77_RS02140	COG4667	esterase of the alpha-beta hydrolase superfamily
LEO77_RS02145	COG3284	Transcriptional regulator
LEO77_RS02155	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LEO77_RS02155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LEO77_RS02155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO77_RS02160	COG1461	Dihydroxyacetone kinase
LEO77_RS02165	COG2376	Dihydroxyacetone kinase
LEO77_RS02170	COG2252	PERMEase
LEO77_RS02175	COG1278	Cold shock
LEO77_RS02185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LEO77_RS02200	COG2197	response regulator
LEO77_RS02235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LEO77_RS02240	COG2199	diguanylate cyclase activity
LEO77_RS02245	COG3047	cAMP biosynthetic process
LEO77_RS02250	COG0840	transmembrane signaling receptor activity
LEO77_RS02275	COG3135	benzoate transporter
LEO77_RS02280	COG1396	sequence-specific DNA binding
LEO77_RS02315	COG2926	Belongs to the UPF0265 family
LEO77_RS02330	COG0561	phosphatase activity
LEO77_RS02340	COG1058	Belongs to the CinA family
LEO77_RS02340	COG1546	Belongs to the CinA family
LEO77_RS02350	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LEO77_RS02360	COG1522	sequence-specific DNA binding
LEO77_RS02365	COG1368	sulfuric ester hydrolase activity
LEO77_RS02400	COG4221	oxidoreductase activity
LEO77_RS02415	COG1979	alcohol dehydrogenase
LEO77_RS02420	COG1803	Methylglyoxal synthase
LEO77_RS02445	COG1444	tRNA N-acetyltransferase activity
LEO77_RS02455	COG0835	chemotaxis
LEO77_RS02455	COG0784	Response regulator, receiver
LEO77_RS02465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LEO77_RS02470	COG2949	membrane
LEO77_RS02475	COG3291	Pkd domain containing protein
LEO77_RS02480	COG0318	PFAM AMP-dependent synthetase and ligase
LEO77_RS02485	COG1441	menaquinone biosynthetic process
LEO77_RS02490	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LEO77_RS02495	COG0596	Alpha beta hydrolase
LEO77_RS02500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LEO77_RS02505	COG1169	isochorismate synthase
LEO77_RS02510	COG1575	Belongs to the MenA family. Type 1 subfamily
LEO77_RS02535	COG0513	Belongs to the DEAD box helicase family
LEO77_RS02540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO77_RS02545	COG1988	membrane-bound metal-dependent
LEO77_RS02550	COG1671	Belongs to the UPF0178 family
LEO77_RS02590	COG0513	Belongs to the DEAD box helicase family
LEO77_RS02615	COG3112	Uncharacterised protein family (UPF0231)
LEO77_RS02620	COG3835	regulator
LEO77_RS02625	COG2610	gluconate transmembrane transporter activity
LEO77_RS02630	COG1929	Belongs to the glycerate kinase type-1 family
LEO77_RS02645	COG0583	DNA-binding transcription factor activity
LEO77_RS02650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO77_RS02660	COG1872	DUF167
LEO77_RS02665	COG0762	integral membrane protein
LEO77_RS02670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LEO77_RS02675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LEO77_RS02690	COG3022	response to hydroperoxide
LEO77_RS02710	COG0347	Belongs to the P(II) protein family
LEO77_RS02715	COG1840	ABC-type Fe3 transport system, periplasmic component
LEO77_RS02725	COG3842	ATPase activity
LEO77_RS02730	COG2837	iron assimilation
LEO77_RS02735	COG1438	arginine binding
LEO77_RS02740	COG1126	abc transporter atp-binding protein
LEO77_RS02745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO77_RS02750	COG4215	(ABC) transporter
LEO77_RS02755	COG4160	amino acid transport
LEO77_RS02760	COG0039	L-malate dehydrogenase activity
LEO77_RS02765	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LEO77_RS02770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO77_RS02770	COG1017	nitric oxide dioxygenase activity
LEO77_RS02780	COG4536	flavin adenine dinucleotide binding
LEO77_RS02785	COG4137	Cytochrome C assembly protein
LEO77_RS02790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LEO77_RS02795	COG0228	four-way junction DNA binding
LEO77_RS02800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LEO77_RS02805	COG0336	Belongs to the RNA methyltransferase TrmD family
LEO77_RS02810	COG0335	large ribosomal subunit rRNA binding
LEO77_RS02820	COG3066	DNA modification
LEO77_RS02825	COG1051	belongs to the nudix hydrolase family
LEO77_RS02835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LEO77_RS02840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LEO77_RS02845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO77_RS02855	COG0583	DNA-binding transcription factor activity
LEO77_RS02860	COG0640	Transcriptional regulator
LEO77_RS02865	COG0268	Binds directly to 16S ribosomal RNA
LEO77_RS02870	COG0728	peptidoglycan biosynthetic process
LEO77_RS02875	COG0196	riboflavin kinase activity
LEO77_RS02880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LEO77_RS02885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LEO77_RS02890	COG1047	Peptidyl-prolyl cis-trans
LEO77_RS02895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LEO77_RS02955	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LEO77_RS02955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEO77_RS02970	COG1854	S-ribosylhomocysteine lyase activity
LEO77_RS02975	COG2165	general secretion pathway protein
LEO77_RS02980	COG0084	hydrolase, TatD family'
LEO77_RS02985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO77_RS02995	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LEO77_RS03000	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LEO77_RS03005	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LEO77_RS03010	COG0813	purine-nucleoside phosphorylase activity
LEO77_RS03020	COG0560	Phosphoserine phosphatase
LEO77_RS03035	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LEO77_RS03050	COG0776	regulation of translation
LEO77_RS03060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LEO77_RS03065	COG1914	H( )-stimulated, divalent metal cation uptake system
LEO77_RS03070	COG0360	Binds together with S18 to 16S ribosomal RNA
LEO77_RS03075	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LEO77_RS03080	COG0359	binds to the 23S rRNA
LEO77_RS03085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO77_RS03110	COG1064	alcohol dehydrogenase
LEO77_RS03115	COG1238	metal cluster binding
LEO77_RS03120	COG0612	Peptidase, M16
LEO77_RS03125	COG2918	glutathione biosynthetic process
LEO77_RS03135	COG1022	Amp-dependent synthetase and ligase
LEO77_RS03145	COG0456	acetyltransferase
LEO77_RS03165	COG3706	GGDEF domain
LEO77_RS03185	COG0477	Major facilitator Superfamily
LEO77_RS03190	COG0583	DNA-binding transcription factor activity
LEO77_RS03200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO77_RS03205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LEO77_RS03215	COG0673	inositol 2-dehydrogenase activity
LEO77_RS03225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LEO77_RS03230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LEO77_RS03235	COG3036	rescue of stalled ribosome
LEO77_RS03245	COG0138	bifunctional purine biosynthesis protein purh
LEO77_RS03250	COG0151	Belongs to the GarS family
LEO77_RS03270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEO77_RS03275	COG0358	DNA primase activity
LEO77_RS03280	COG1610	YqeY-like protein
LEO77_RS03285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LEO77_RS03290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LEO77_RS03295	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LEO77_RS03300	COG1027	Aspartate ammonia-lyase
LEO77_RS03305	COG3030	protein affecting phage T7 exclusion by the F plasmid
LEO77_RS03310	COG0534	Mate efflux family protein
LEO77_RS03315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LEO77_RS03320	COG0459	protein refolding
LEO77_RS03360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO77_RS03370	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LEO77_RS03375	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LEO77_RS03380	COG1178	ABC-type Fe3 transport system permease component
LEO77_RS03385	COG4143	(ABC) transporter
LEO77_RS03400	COG0066	3-isopropylmalate dehydratase activity
LEO77_RS03405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LEO77_RS03410	COG0473	3-isopropylmalate dehydrogenase activity
LEO77_RS03415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LEO77_RS03445	COG0028	Belongs to the TPP enzyme family
LEO77_RS03450	COG0440	acetolactate synthase activity
LEO77_RS03485	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LEO77_RS03490	COG2190	(PTS) system
LEO77_RS03490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO77_RS03490	COG1263	PTS System
LEO77_RS03500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO77_RS03500	COG2205	protein histidine kinase activity
LEO77_RS03510	COG2885	chlorophyll binding
LEO77_RS03510	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LEO77_RS03555	COG3188	usher protein
LEO77_RS03590	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LEO77_RS03605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO77_RS03635	COG0745	RESPONSE REGULATOR receiver
LEO77_RS03640	COG3104	oligopeptide transport
LEO77_RS03645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LEO77_RS03650	COG1555	photosystem II stabilization
LEO77_RS03655	COG0857	belongs to the CobB CobQ family
LEO77_RS03655	COG0280	phosphate acetyltransferase
LEO77_RS03660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LEO77_RS03670	COG3013	Belongs to the UPF0304 family
LEO77_RS03675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LEO77_RS03680	COG2716	regulation of RNA biosynthetic process
LEO77_RS03685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LEO77_RS03690	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LEO77_RS03695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LEO77_RS03730	COG0784	Response regulator, receiver
LEO77_RS03730	COG2198	Histidine kinase
LEO77_RS03730	COG5002	protein histidine kinase activity
LEO77_RS03750	COG2203	Gaf domain
LEO77_RS03750	COG5001	Diguanylate cyclase
LEO77_RS03750	COG4251	negative regulation of phosphorylation
LEO77_RS03750	COG3706	GGDEF domain
LEO77_RS03765	COG1464	Belongs to the NlpA lipoprotein family
LEO77_RS03770	COG2011	ABC-type metal ion transport system permease component
LEO77_RS03775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LEO77_RS03795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LEO77_RS03795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LEO77_RS03800	COG0802	atpase or kinase
LEO77_RS03810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LEO77_RS03815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LEO77_RS03820	COG1923	regulation of RNA biosynthetic process
LEO77_RS03825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LEO77_RS03830	COG0330	HflC and HflK could
LEO77_RS03835	COG0330	HflC and HflK could
LEO77_RS03840	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LEO77_RS03845	COG0142	geranyltranstransferase activity
LEO77_RS03850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LEO77_RS03855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LEO77_RS03860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LEO77_RS03865	COG3314	Sporulation integral membrane protein YlbJ
LEO77_RS03875	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO77_RS03880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LEO77_RS03890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LEO77_RS03895	COG2967	ApaG domain
LEO77_RS03900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LEO77_RS03905	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LEO77_RS03910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEO77_RS03915	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LEO77_RS03920	COG3178	'Phosphotransferase
LEO77_RS03925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LEO77_RS03930	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LEO77_RS03935	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO77_RS03940	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LEO77_RS03945	COG1073	alpha beta
LEO77_RS03960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LEO77_RS03975	COG4628	conserved protein (DUF2132)
LEO77_RS03980	COG0688	phosphatidylethanolamine metabolic process
LEO77_RS03985	COG1162	GTPase activity
LEO77_RS03990	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LEO77_RS04030	COG1278	Cold shock
LEO77_RS04040	COG0840	transmembrane signaling receptor activity
LEO77_RS04045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO77_RS04055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEO77_RS04060	COG4991	sh3 domain protein
LEO77_RS04070	COG2816	NAD+ diphosphatase activity
LEO77_RS04075	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LEO77_RS04080	COG1940	carbohydrate kinase activity
LEO77_RS04085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEO77_RS04090	COG0126	phosphoglycerate kinase activity
LEO77_RS04095	COG0191	fructose-bisphosphate aldolase activity
LEO77_RS04100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO77_RS04145	COG0354	folic acid binding
LEO77_RS04150	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LEO77_RS04160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LEO77_RS04165	COG1595	DNA-templated transcription, initiation
LEO77_RS04170	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LEO77_RS04175	COG3026	antisigma factor binding
LEO77_RS04185	COG0481	GTPase activity
LEO77_RS04190	COG0681	Belongs to the peptidase S26 family
LEO77_RS04205	COG1381	Involved in DNA repair and RecF pathway recombination
LEO77_RS04210	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LEO77_RS04220	COG2350	Protein conserved in bacteria
LEO77_RS04225	COG2917	probably involved in intracellular septation
LEO77_RS04230	COG0076	glutamate decarboxylase activity
LEO77_RS04235	COG1272	protein, Hemolysin III
LEO77_RS04240	COG0569	domain protein
LEO77_RS04240	COG2985	domain, Protein
LEO77_RS04255	COG5001	Diguanylate cyclase
LEO77_RS04255	COG3300	MHYT domain
LEO77_RS04260	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LEO77_RS04280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO77_RS04315	COG4974	Belongs to the 'phage' integrase family
LEO77_RS04345	COG0582	viral genome integration into host DNA
LEO77_RS04370	COG2313	pseudouridylate synthase activity
LEO77_RS04375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO77_RS04405	COG2226	methyltransferase
LEO77_RS04415	COG1765	OsmC-like protein
LEO77_RS04430	COG3954	Phosphoribulokinase
LEO77_RS04435	COG3089	Belongs to the UPF0270 family
LEO77_RS04440	COG2203	Gaf domain
LEO77_RS04440	COG3706	GGDEF domain
LEO77_RS04440	COG4251	negative regulation of phosphorylation
LEO77_RS04440	COG5001	Diguanylate cyclase
LEO77_RS04445	COG0429	hydrolase of the alpha beta-hydrolase fold
LEO77_RS04450	COG0784	Response regulator, receiver
LEO77_RS04450	COG0835	chemotaxis
LEO77_RS04460	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LEO77_RS04465	COG1047	Peptidyl-prolyl cis-trans
LEO77_RS04480	COG0545	Peptidyl-prolyl cis-trans isomerase
LEO77_RS04485	COG2204	response regulator
LEO77_RS04505	COG0737	Belongs to the 5'-nucleotidase family
LEO77_RS04520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO77_RS04545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO77_RS04555	COG3721	Heme iron utilization protein
LEO77_RS04560	COG0748	coenzyme F420 binding
LEO77_RS04585	COG2814	Major facilitator Superfamily
LEO77_RS04595	COG3655	Transcriptional regulator
LEO77_RS04605	COG2202	Pas domain
LEO77_RS04605	COG2205	protein histidine kinase activity
LEO77_RS04610	COG2755	lipolytic protein G-D-S-L family
LEO77_RS04615	COG4181	ATPase activity
LEO77_RS04620	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LEO77_RS04625	COG1090	epimerase
LEO77_RS04630	COG2200	EAL domain
LEO77_RS04635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO77_RS04640	COG2234	aminopeptidase activity
LEO77_RS04640	COG4935	Belongs to the peptidase S8 family
LEO77_RS04645	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LEO77_RS04650	COG3171	Protein conserved in bacteria
LEO77_RS04655	COG2066	Belongs to the glutaminase family
LEO77_RS04660	COG2897	thiosulfate sulfurtransferase activity
LEO77_RS04680	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEO77_RS04690	COG2966	Psort location CytoplasmicMembrane, score
LEO77_RS04695	COG3610	response to peptide
LEO77_RS04705	COG4175	Glycine betaine
LEO77_RS04710	COG4176	ABC-type proline glycine betaine transport system permease component
LEO77_RS04715	COG2113	Glycine betaine
LEO77_RS04725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO77_RS04730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEO77_RS04735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LEO77_RS04750	COG0786	glutamate:sodium symporter activity
LEO77_RS04755	COG0252	asparaginase activity
LEO77_RS04760	COG3139	Protein of unknown function (DUF1315)
LEO77_RS04780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LEO77_RS04785	COG0321	lipoyl(octanoyl) transferase activity
LEO77_RS04790	COG2921	Belongs to the UPF0250 family
LEO77_RS04795	COG1686	Belongs to the peptidase S11 family
LEO77_RS04800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LEO77_RS04805	COG2951	lytic endotransglycosylase activity
LEO77_RS04810	COG0772	Belongs to the SEDS family
LEO77_RS04815	COG0768	penicillin binding
LEO77_RS04820	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LEO77_RS04825	COG0799	negative regulation of ribosome biogenesis
LEO77_RS04830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LEO77_RS04845	COG0495	leucyl-tRNA aminoacylation
LEO77_RS04850	COG2888	peptidyl-tyrosine sulfation
LEO77_RS04855	COG0312	modulator of DNA gyrase
LEO77_RS04865	COG0716	FMN binding
LEO77_RS04870	COG4974	Belongs to the 'phage' integrase family
LEO77_RS04875	COG1970	mechanosensitive ion channel activity
LEO77_RS04885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LEO77_RS04895	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO77_RS04900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LEO77_RS04905	COG4535	Mg2 and Co2 transporter CorC
LEO77_RS04910	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LEO77_RS04915	COG1702	phosphate starvation-inducible protein PhoH
LEO77_RS04920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEO77_RS04925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO77_RS04955	COG3069	C4-dicarboxylate transmembrane transporter activity
LEO77_RS04965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LEO77_RS04970	COG0583	DNA-binding transcription factor activity
LEO77_RS04980	COG5002	protein histidine kinase activity
LEO77_RS04980	COG3447	MASE1 domain protein
LEO77_RS04980	COG5001	Diguanylate cyclase
LEO77_RS04990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEO77_RS05000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LEO77_RS05010	COG0516	GMP reductase activity
LEO77_RS05020	COG0642	Histidine kinase
LEO77_RS05035	COG4221	oxidoreductase activity
LEO77_RS05045	COG1022	Amp-dependent synthetase and ligase
LEO77_RS05060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO77_RS05075	COG3214	Protein conserved in bacteria
LEO77_RS05085	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LEO77_RS05090	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LEO77_RS05095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LEO77_RS05100	COG1053	succinate dehydrogenase
LEO77_RS05110	COG0584	glycerophosphoryl diester phosphodiesterase
LEO77_RS05115	COG1511	domain protein
LEO77_RS05115	COG3264	Mechanosensitive ion channel
LEO77_RS05125	COG0739	heme binding
LEO77_RS05135	COG0583	DNA-binding transcription factor activity
LEO77_RS05155	COG0583	DNA-binding transcription factor activity
LEO77_RS05160	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LEO77_RS05190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LEO77_RS05195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LEO77_RS05205	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LEO77_RS05210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LEO77_RS05220	COG0180	Tryptophanyl-tRNA synthetase
LEO77_RS05235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LEO77_RS05245	COG1012	belongs to the aldehyde dehydrogenase family
LEO77_RS05255	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LEO77_RS05260	COG0739	heme binding
LEO77_RS05265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEO77_RS05295	COG0814	amino acid
LEO77_RS05310	COG0531	amino acid
LEO77_RS05315	COG3710	Transcriptional regulator
LEO77_RS05320	COG0531	amino acid
LEO77_RS05325	COG1982	Orn Lys Arg decarboxylase major
LEO77_RS05330	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LEO77_RS05340	COG3590	peptidase
LEO77_RS05350	COG2199	diguanylate cyclase activity
LEO77_RS05350	COG2203	Gaf domain
LEO77_RS05385	COG0366	Alpha amylase catalytic
LEO77_RS05400	COG0463	Glycosyl transferase, family 2
LEO77_RS05415	COG2989	Protein conserved in bacteria
LEO77_RS05420	COG3108	Peptidase M15
LEO77_RS05430	COG2860	membrane
LEO77_RS05440	COG1196	nuclear chromosome segregation
LEO77_RS05445	COG3115	cell septum assembly
LEO77_RS05450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LEO77_RS05455	COG3408	Glycogen debranching enzyme
LEO77_RS05455	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LEO77_RS05465	COG1881	PFAM PEBP family protein
LEO77_RS05470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LEO77_RS05485	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LEO77_RS05495	COG0583	DNA-binding transcription factor activity
LEO77_RS05500	COG1028	Short-chain dehydrogenase reductase Sdr
LEO77_RS05505	COG0616	signal peptide processing
LEO77_RS05510	COG2211	Major facilitator Superfamily
LEO77_RS05525	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO77_RS05530	COG0826	peptidase U32
LEO77_RS05555	COG3724	N-succinylarginine dihydrolase activity
LEO77_RS05575	COG0840	transmembrane signaling receptor activity
LEO77_RS05585	COG2971	BadF BadG BcrA BcrD
LEO77_RS05595	COG4608	Belongs to the ABC transporter superfamily
LEO77_RS05600	COG0444	Belongs to the ABC transporter superfamily
LEO77_RS05605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO77_RS05620	COG0784	Response regulator, receiver
LEO77_RS05620	COG2205	protein histidine kinase activity
LEO77_RS05650	COG3220	belongs to the UPF0276 family
LEO77_RS05680	COG1289	transmembrane transporter activity
LEO77_RS05685	COG0303	'Molybdopterin
LEO77_RS05690	COG0746	molybdenum cofactor guanylyltransferase activity
LEO77_RS05700	COG4662	Binding-protein-dependent transport system inner membrane component
LEO77_RS05710	COG2204	response regulator
LEO77_RS05715	COG3852	Histidine kinase
LEO77_RS05725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LEO77_RS05760	COG3383	formate dehydrogenase (NAD+) activity
LEO77_RS05760	COG3383	formate dehydrogenase (NAD+) activity
LEO77_RS05765	COG0437	4 iron, 4 sulfur cluster binding
LEO77_RS05785	COG0281	malic enzyme
LEO77_RS05805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO77_RS05830	COG1737	Transcriptional regulator
LEO77_RS05835	COG0469	pyruvate kinase activity
LEO77_RS05845	COG1032	radical SAM domain protein
LEO77_RS05880	COG0673	inositol 2-dehydrogenase activity
LEO77_RS05885	COG2920	part of a sulfur-relay system
LEO77_RS05890	COG1289	transmembrane transporter activity
LEO77_RS05895	COG0670	Belongs to the BI1 family
LEO77_RS05910	COG1486	melibiose metabolic process
LEO77_RS05915	COG1917	Cupin 2, conserved barrel domain protein
LEO77_RS05915	COG2169	Transcriptional regulator
LEO77_RS05920	COG1447	Phosphotransferase system cellobiose-specific component IIA
LEO77_RS05925	COG2723	6-phospho-beta-galactosidase activity
LEO77_RS05930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LEO77_RS05935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LEO77_RS05940	COG1447	Phosphotransferase system cellobiose-specific component IIA
LEO77_RS05945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LEO77_RS05955	COG1446	asparaginase
LEO77_RS05960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LEO77_RS05980	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LEO77_RS05990	COG3156	type II secretion system protein K
LEO77_RS05995	COG4795	General secretion pathway protein
LEO77_RS06000	COG2165	general secretion pathway protein
LEO77_RS06010	COG2165	general secretion pathway protein
LEO77_RS06015	COG1459	type II secretion system
LEO77_RS06020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO77_RS06030	COG3031	protein transport across the cell outer membrane
LEO77_RS06040	COG3267	Type II secretory pathway component ExeA
LEO77_RS06040	COG3409	Peptidoglycan-binding domain 1 protein
LEO77_RS06055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LEO77_RS06060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LEO77_RS06065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO77_RS06075	COG2190	(PTS) system
LEO77_RS06080	COG3706	GGDEF domain
LEO77_RS06085	COG3264	Mechanosensitive ion channel
LEO77_RS06085	COG1196	nuclear chromosome segregation
LEO77_RS06090	COG0469	pyruvate kinase activity
LEO77_RS06100	COG3384	dioxygenase
LEO77_RS06105	COG0419	ATPase involved in DNA repair
LEO77_RS06110	COG0420	3'-5' exonuclease activity
LEO77_RS06120	COG2974	May be involved in recombination
LEO77_RS06130	COG0545	Peptidyl-prolyl cis-trans isomerase
LEO77_RS06135	COG1283	sodium-dependent phosphate transmembrane transporter activity
LEO77_RS06145	COG0531	amino acid
LEO77_RS06155	COG0531	amino acid
LEO77_RS06170	COG1917	Cupin 2, conserved barrel domain protein
LEO77_RS06170	COG1396	sequence-specific DNA binding
LEO77_RS06175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO77_RS06185	COG2862	Uncharacterized protein family, UPF0114
LEO77_RS06200	COG3038	cytochrome b561
LEO77_RS06205	COG1720	tRNA m6t6A37 methyltransferase activity
LEO77_RS06225	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LEO77_RS06230	COG4988	ABC transporter
LEO77_RS06245	COG0745	RESPONSE REGULATOR receiver
LEO77_RS06255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LEO77_RS06270	COG0640	Transcriptional regulator
LEO77_RS06285	COG0798	PFAM Bile acid sodium symporter
LEO77_RS06295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LEO77_RS06310	COG1988	membrane-bound metal-dependent
LEO77_RS06330	COG0159	tryptophan synthase activity
LEO77_RS06335	COG0133	tryptophan synthase activity
LEO77_RS06340	COG0134	indole-3-glycerol-phosphate synthase activity
LEO77_RS06340	COG0135	phosphoribosylanthranilate isomerase activity
LEO77_RS06345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEO77_RS06350	COG0512	Glutamine amidotransferase of anthranilate synthase
LEO77_RS06350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LEO77_RS06355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LEO77_RS06365	COG0009	L-threonylcarbamoyladenylate synthase
LEO77_RS06375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LEO77_RS06385	COG1946	Acyl-CoA thioesterase
LEO77_RS06390	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LEO77_RS06395	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LEO77_RS06405	COG0083	homoserine kinase activity
LEO77_RS06410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEO77_RS06435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO77_RS06470	COG0741	lytic transglycosylase activity
LEO77_RS06470	COG1388	LysM domain
LEO77_RS06475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEO77_RS06480	COG2226	methyltransferase
LEO77_RS06485	COG0328	RNA-DNA hybrid ribonuclease activity
LEO77_RS06490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LEO77_RS06500	COG0784	Response regulator, receiver
LEO77_RS06500	COG3437	response regulator, receiver
LEO77_RS06505	COG2375	cellular response to nickel ion
LEO77_RS06510	COG4771	TonB-dependent receptor
LEO77_RS06515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO77_RS06520	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LEO77_RS06525	COG1120	ATPase activity
LEO77_RS06530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LEO77_RS06545	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO77_RS06550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO77_RS06575	COG0708	Exodeoxyribonuclease III
LEO77_RS06610	COG3132	Protein of unknown function, DUF480
LEO77_RS06625	COG2841	Protein conserved in bacteria
LEO77_RS06635	COG0534	Mate efflux family protein
LEO77_RS06655	COG1454	alcohol dehydrogenase
LEO77_RS06665	COG1309	transcriptional regulator
LEO77_RS06700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LEO77_RS06705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LEO77_RS06710	COG1845	cytochrome c oxidase, subunit III
LEO77_RS06715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LEO77_RS06720	COG0109	protoheme IX farnesyltransferase activity
LEO77_RS06725	COG2814	Major facilitator Superfamily
LEO77_RS06730	COG3152	Membrane
LEO77_RS06750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO77_RS06755	COG3537	Alpha-1,2-mannosidase
LEO77_RS06770	COG3537	Alpha-1,2-mannosidase
LEO77_RS06780	COG2207	Transcriptional regulator
LEO77_RS06785	COG0538	isocitrate dehydrogenase activity
LEO77_RS06800	COG0791	NLP P60 protein
LEO77_RS06805	COG0583	DNA-binding transcription factor activity
LEO77_RS06810	COG0450	alkyl hydroperoxide reductase
LEO77_RS06830	COG0500	methyltransferase
LEO77_RS06835	COG4106	trans-aconitate 2-methyltransferase activity
LEO77_RS06840	COG1801	Protein of unknown function DUF72
LEO77_RS06850	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LEO77_RS06855	COG0217	transcriptional regulatory protein
LEO77_RS06860	COG1454	alcohol dehydrogenase
LEO77_RS06860	COG1012	belongs to the aldehyde dehydrogenase family
LEO77_RS06865	COG2095	MarC family integral membrane protein
LEO77_RS06875	COG0601	transmembrane transport
LEO77_RS06880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO77_RS06895	COG0861	Integral membrane protein TerC family
LEO77_RS06900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LEO77_RS06930	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LEO77_RS06935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO77_RS06940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LEO77_RS06945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEO77_RS06950	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LEO77_RS06955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LEO77_RS06965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LEO77_RS06970	COG0505	Belongs to the CarA family
LEO77_RS06975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LEO77_RS06990	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LEO77_RS07010	COG0346	lactoylglutathione lyase activity
LEO77_RS07015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LEO77_RS07020	COG4660	Part of a membrane complex involved in electron transport
LEO77_RS07025	COG4659	FMN binding
LEO77_RS07030	COG4658	electron transport chain
LEO77_RS07040	COG2878	Part of a membrane complex involved in electron transport
LEO77_RS07045	COG4657	Part of a membrane complex involved in electron transport
LEO77_RS07050	COG1061	Type III restriction enzyme res subunit
LEO77_RS07070	COG1187	pseudouridine synthase activity
LEO77_RS07075	COG2807	transmembrane transport
LEO77_RS07080	COG0583	DNA-binding transcription factor activity
LEO77_RS07090	COG1607	acyl-coa hydrolase
LEO77_RS07100	COG2979	Protein of unknown function (DUF533)
LEO77_RS07110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO77_RS07120	COG1294	oxidase, subunit
LEO77_RS07140	COG3220	belongs to the UPF0276 family
LEO77_RS07155	COG2249	NAD(P)H dehydrogenase (quinone) activity
LEO77_RS07160	COG2814	Major facilitator Superfamily
LEO77_RS07165	COG0656	L-ascorbic acid biosynthetic process
LEO77_RS07190	COG0583	DNA-binding transcription factor activity
LEO77_RS07200	COG0840	transmembrane signaling receptor activity
LEO77_RS07205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LEO77_RS07210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEO77_RS07215	COG2271	Major facilitator Superfamily
LEO77_RS07220	COG1349	DNA-binding transcription factor activity
LEO77_RS07230	COG0584	glycerophosphoryl diester phosphodiesterase
LEO77_RS07235	COG4574	serine-type endopeptidase inhibitor activity
LEO77_RS07240	COG3085	chromosome segregation
LEO77_RS07245	COG0583	DNA-binding transcription factor activity
LEO77_RS07255	COG1448	Aminotransferase
LEO77_RS07270	COG0658	competence protein
LEO77_RS07270	COG2333	competence protein COMEC
LEO77_RS07280	COG1663	tetraacyldisaccharide 4'-kinase activity
LEO77_RS07285	COG2835	tetraacyldisaccharide 4'-kinase activity
LEO77_RS07290	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LEO77_RS07295	COG2197	response regulator
LEO77_RS07300	COG0322	excinuclease ABC activity
LEO77_RS07350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LEO77_RS07360	COG0215	cysteine-tRNA ligase activity
LEO77_RS07365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEO77_RS07375	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO77_RS07385	COG3301	Polysulphide reductase, NrfD
LEO77_RS07390	COG0437	4 iron, 4 sulfur cluster binding
LEO77_RS07395	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LEO77_RS07450	COG2119	membrane
LEO77_RS07455	COG0023	Translation Initiation Factor
LEO77_RS07480	COG0513	Belongs to the DEAD box helicase family
LEO77_RS07485	COG0493	'glutamate synthase
LEO77_RS07490	COG0070	glutamate synthase
LEO77_RS07490	COG0067	glutamate synthase
LEO77_RS07490	COG0069	glutamate synthase activity
LEO77_RS07495	COG1242	4 iron, 4 sulfur cluster binding
LEO77_RS07550	COG3634	alkyl hydroperoxide reductase activity
LEO77_RS07560	COG0517	IMP dehydrogenase activity
LEO77_RS07565	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LEO77_RS07570	COG0343	queuine tRNA-ribosyltransferase activity
LEO77_RS07575	COG1862	Preprotein translocase
LEO77_RS07580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO77_RS07585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO77_RS07590	COG2897	thiosulfate sulfurtransferase activity
LEO77_RS07620	COG1464	Belongs to the NlpA lipoprotein family
LEO77_RS07625	COG3083	sulfuric ester hydrolase activity
LEO77_RS07630	COG3082	Protein of unknown function (DUF1414)
LEO77_RS07635	COG3081	Nucleoid-associated protein
LEO77_RS07645	COG1175	transmembrane transport
LEO77_RS07650	COG3833	ABC-type maltose transport systems, permease component
LEO77_RS07655	COG3842	ATPase activity
LEO77_RS07680	COG0425	Belongs to the sulfur carrier protein TusA family
LEO77_RS07685	COG4783	chaperone-mediated protein folding
LEO77_RS07700	COG1393	Belongs to the ArsC family
LEO77_RS07710	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LEO77_RS07715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO77_RS07720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO77_RS07725	COG2431	L-lysine efflux transmembrane transporter activity
LEO77_RS07735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO77_RS07745	COG4160	amino acid transport
LEO77_RS07750	COG0564	pseudouridine synthase activity
LEO77_RS07765	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LEO77_RS07775	COG0625	glutathione transferase activity
LEO77_RS07825	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LEO77_RS07845	COG0438	transferase activity, transferring glycosyl groups
LEO77_RS07870	COG0367	asparagine synthase
LEO77_RS07880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LEO77_RS07880	COG4651	solute:proton antiporter activity
LEO77_RS07885	COG0647	UMP catabolic process
LEO77_RS07895	COG0604	alcohol dehydrogenase
LEO77_RS07895	COG1028	Short-chain dehydrogenase reductase Sdr
LEO77_RS07895	COG3321	synthase
LEO77_RS07900	COG1902	pentaerythritol trinitrate reductase activity
LEO77_RS07905	COG1253	flavin adenine dinucleotide binding
LEO77_RS08030	COG0640	Transcriptional regulator
LEO77_RS08040	COG4373	Mu-like prophage FluMu protein gp28
LEO77_RS08045	COG4383	Mu-like prophage protein gp29
LEO77_RS08065	COG4388	Caudovirus prohead serine protease
LEO77_RS08070	COG4397	Mu-like prophage major head subunit gpT
LEO77_RS08100	COG3941	tape measure
LEO77_RS08150	COG0277	FAD linked oxidase domain protein
LEO77_RS08150	COG0247	lactate metabolic process
LEO77_RS08160	COG2050	protein possibly involved in aromatic compounds catabolism
LEO77_RS08165	COG0513	Belongs to the DEAD box helicase family
LEO77_RS08185	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LEO77_RS08195	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LEO77_RS08200	COG0765	amino acid transport
LEO77_RS08205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO77_RS08210	COG0765	amino acid transport
LEO77_RS08215	COG1126	abc transporter atp-binding protein
LEO77_RS08225	COG0724	RNA recognition motif
LEO77_RS08230	COG4989	oxidoreductase activity
LEO77_RS08255	COG3437	response regulator, receiver
LEO77_RS08260	COG0583	DNA-binding transcription factor activity
LEO77_RS08270	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LEO77_RS08290	COG2814	Major facilitator Superfamily
LEO77_RS08305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEO77_RS08310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LEO77_RS08315	COG0539	negative regulation of cytoplasmic translation
LEO77_RS08320	COG0776	regulation of translation
LEO77_RS08330	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LEO77_RS08350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LEO77_RS08355	COG0602	queuosine metabolic process
LEO77_RS08360	COG3530	Putative quorum-sensing-regulated virulence factor
LEO77_RS08365	COG2096	Adenosyltransferase
LEO77_RS08370	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO77_RS08375	COG1757	Na H antiporter
LEO77_RS08380	COG1435	thymidine kinase activity
LEO77_RS08405	COG0392	lysyltransferase activity
LEO77_RS08405	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LEO77_RS08415	COG2205	protein histidine kinase activity
LEO77_RS08420	COG0745	RESPONSE REGULATOR receiver
LEO77_RS08440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LEO77_RS08445	COG1278	Cold shock
LEO77_RS08450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LEO77_RS08455	COG0542	response to heat
LEO77_RS08460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LEO77_RS08465	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LEO77_RS08470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LEO77_RS08475	COG3134	Outer membrane lipoprotein
LEO77_RS08480	COG3706	GGDEF domain
LEO77_RS08485	COG0492	ferredoxin-NADP+ reductase activity
LEO77_RS08490	COG0686	Belongs to the AlaDH PNT family
LEO77_RS08500	COG0531	amino acid
LEO77_RS08500	COG1674	ftsk spoiiie
LEO77_RS08505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LEO77_RS08510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LEO77_RS08515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LEO77_RS08520	COG1286	toxin biosynthetic process
LEO77_RS08525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LEO77_RS08535	COG0563	adenylate kinase activity
LEO77_RS08540	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LEO77_RS08550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO77_RS08565	COG3300	MHYT domain
LEO77_RS08565	COG5001	Diguanylate cyclase
LEO77_RS08595	COG0514	ATP-dependent DNA helicase (RecQ)
LEO77_RS08600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LEO77_RS08640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LEO77_RS08675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LEO77_RS08705	COG0582	viral genome integration into host DNA
LEO77_RS08720	COG0659	secondary active sulfate transmembrane transporter activity
LEO77_RS08735	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LEO77_RS08765	COG2211	Major facilitator Superfamily
LEO77_RS08770	COG2211	Major facilitator Superfamily
LEO77_RS08780	COG1501	Belongs to the glycosyl hydrolase 31 family
LEO77_RS08800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LEO77_RS08805	COG0326	Molecular chaperone. Has ATPase activity
LEO77_RS08810	COG4172	Belongs to the ABC transporter superfamily
LEO77_RS08815	COG4172	Belongs to the ABC transporter superfamily
LEO77_RS08825	COG4168	peptide transport system, permease
LEO77_RS08835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LEO77_RS08840	COG1842	Phage shock protein A
LEO77_RS08855	COG3106	COG3106 Predicted ATPase
LEO77_RS08860	COG3768	UPF0283 membrane protein
LEO77_RS08865	COG0583	DNA-binding transcription factor activity
LEO77_RS08870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LEO77_RS08875	COG3842	ATPase activity
LEO77_RS08880	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEO77_RS08885	COG1177	transmembrane transport
LEO77_RS08890	COG1012	belongs to the aldehyde dehydrogenase family
LEO77_RS08900	COG2154	pterin-4-alpha-carbinolamine dehydratase
LEO77_RS08920	COG2885	chlorophyll binding
LEO77_RS08925	COG0861	Integral membrane protein TerC family
LEO77_RS08955	COG2910	NAD(P)H-binding
LEO77_RS08960	COG0583	DNA-binding transcription factor activity
LEO77_RS08965	COG2271	Major facilitator Superfamily
LEO77_RS08975	COG1335	isochorismatase
LEO77_RS08985	COG0583	DNA-binding transcription factor activity
LEO77_RS08990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LEO77_RS09000	COG0583	DNA-binding transcription factor activity
LEO77_RS09005	COG2723	6-phospho-beta-galactosidase activity
LEO77_RS09010	COG1944	ATP diphosphatase activity
LEO77_RS09015	COG2116	formate transmembrane transporter activity
LEO77_RS09020	COG1882	Formate acetyltransferase
LEO77_RS09025	COG2983	Belongs to the UPF0260 family
LEO77_RS09040	COG0058	SHG alpha-glucan phosphorylase activity
LEO77_RS09045	COG0471	metal ion transport
LEO77_RS09050	COG3118	belongs to the thioredoxin family
LEO77_RS09060	COG1132	(ABC) transporter
LEO77_RS09065	COG1132	(ABC) transporter
LEO77_RS09075	COG2501	S4 domain
LEO77_RS09090	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LEO77_RS09130	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LEO77_RS09135	COG1053	succinate dehydrogenase
LEO77_RS09145	COG0567	Dehydrogenase, E1 component
LEO77_RS09150	COG0508	dehydrogenase complex catalyzes the overall conversion of
LEO77_RS09155	COG0045	succinate-CoA ligase (ADP-forming) activity
LEO77_RS09170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO77_RS09180	COG3842	ATPase activity
LEO77_RS09185	COG1840	ABC-type Fe3 transport system, periplasmic component
LEO77_RS09195	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LEO77_RS09205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO77_RS09220	COG4235	cytochrome complex assembly
LEO77_RS09220	COG3088	subunit of a heme lyase
LEO77_RS09230	COG1138	Cytochrome C-type biogenesis protein
LEO77_RS09235	COG3301	Polysulphide reductase, NrfD
LEO77_RS09240	COG0437	4 iron, 4 sulfur cluster binding
LEO77_RS09245	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LEO77_RS09255	COG0247	lactate metabolic process
LEO77_RS09260	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LEO77_RS09265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LEO77_RS09270	COG3012	SEC-C Motif Domain Protein
LEO77_RS09275	COG0840	transmembrane signaling receptor activity
LEO77_RS09280	COG1846	Transcriptional regulator
LEO77_RS09280	COG1940	carbohydrate kinase activity
LEO77_RS09285	COG3148	PFAM DTW domain containing protein
LEO77_RS09290	COG0730	response to heat
LEO77_RS09295	COG0583	DNA-binding transcription factor activity
LEO77_RS09310	COG3593	DNA synthesis involved in DNA repair
LEO77_RS09355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO77_RS09360	COG1011	Hydrolase
LEO77_RS09375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEO77_RS09380	COG2832	Protein of unknown function (DUF454)
LEO77_RS09385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LEO77_RS09395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LEO77_RS09400	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LEO77_RS09415	COG1560	Kdo2-lipid A biosynthetic process
LEO77_RS09420	COG1560	Kdo2-lipid A biosynthetic process
LEO77_RS09445	COG0417	DNA replication proofreading
LEO77_RS09460	COG1451	nucleotide metabolic process
LEO77_RS09475	COG3069	C4-dicarboxylate transmembrane transporter activity
LEO77_RS09490	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LEO77_RS09490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO77_RS09495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO77_RS09505	COG0569	domain protein
LEO77_RS09505	COG2985	domain, Protein
LEO77_RS09515	COG0556	nucleotide-excision repair
LEO77_RS09525	COG0586	Pfam SNARE associated Golgi protein
LEO77_RS09530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LEO77_RS09535	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO77_RS09550	COG4681	YaeQ
LEO77_RS09565	COG3829	transcription factor binding
LEO77_RS09605	COG0307	riboflavin synthase, alpha
LEO77_RS09610	COG2223	nitrite transmembrane transporter activity
LEO77_RS09615	COG3250	beta-galactosidase activity
LEO77_RS09620	COG4580	involved in the transport of maltose and maltodextrins
LEO77_RS09625	COG2211	Major facilitator Superfamily
LEO77_RS09635	COG1388	LysM domain
LEO77_RS09635	COG2373	Large extracellular alpha-helical protein
LEO77_RS09635	COG4932	domain protein
LEO77_RS09655	COG5001	Diguanylate cyclase
LEO77_RS09675	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO77_RS09680	COG0517	IMP dehydrogenase activity
LEO77_RS09680	COG0617	tRNA 3'-terminal CCA addition
LEO77_RS09680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LEO77_RS09685	COG1643	Atp-dependent helicase
LEO77_RS09695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LEO77_RS09710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LEO77_RS09715	COG2067	long-chain fatty acid transport protein
LEO77_RS09720	COG2067	long-chain fatty acid transport protein
LEO77_RS09730	COG1595	DNA-templated transcription, initiation
LEO77_RS09740	COG2304	oxidoreductase activity
LEO77_RS09760	COG0714	Associated with various cellular activities
LEO77_RS09765	COG0183	Belongs to the thiolase family
LEO77_RS09770	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEO77_RS09770	COG1024	Enoyl-CoA hydratase
LEO77_RS09775	COG2719	SpoVR family
LEO77_RS09780	COG2718	Belongs to the UPF0229 family
LEO77_RS09785	COG2766	serine protein kinase
LEO77_RS09790	COG0514	ATP-dependent DNA helicase (RecQ)
LEO77_RS09795	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LEO77_RS09800	COG0814	amino acid
LEO77_RS09805	COG0494	nUDIX hydrolase
LEO77_RS09820	COG2824	Alkylphosphonate utilization operon protein PhnA
LEO77_RS09840	COG3791	Glutathione-dependent formaldehyde-activating
LEO77_RS09850	COG2840	Smr protein MutS2
LEO77_RS09855	COG2890	protein-(glutamine-N5) methyltransferase activity
LEO77_RS09860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LEO77_RS09870	COG0513	Belongs to the DEAD box helicase family
LEO77_RS09875	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LEO77_RS09890	COG0814	amino acid
LEO77_RS09895	COG1609	Transcriptional regulator
LEO77_RS09900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO77_RS09900	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO77_RS09905	COG1105	Belongs to the carbohydrate kinase PfkB family
LEO77_RS09910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO77_RS09910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO77_RS09910	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LEO77_RS09915	COG3313	Fe-S protein
LEO77_RS09920	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LEO77_RS09925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO77_RS09930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO77_RS09935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LEO77_RS09945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEO77_RS09955	COG0366	Alpha amylase catalytic
LEO77_RS09975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LEO77_RS09980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LEO77_RS09985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LEO77_RS09990	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LEO77_RS10000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LEO77_RS10005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO77_RS10005	COG0072	phenylalanine-tRNA ligase activity
LEO77_RS10010	COG0776	regulation of translation
LEO77_RS10040	COG5001	Diguanylate cyclase
LEO77_RS10040	COG3300	MHYT domain
LEO77_RS10045	COG1609	Transcriptional regulator
LEO77_RS10050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LEO77_RS10055	COG1879	ABC-type sugar transport system periplasmic component
LEO77_RS10060	COG1172	Belongs to the binding-protein-dependent transport system permease family
LEO77_RS10065	COG1129	ABC transporter
LEO77_RS10070	COG1869	D-ribose catabolic process
LEO77_RS10075	COG0625	glutathione transferase activity
LEO77_RS10090	COG1177	transmembrane transport
LEO77_RS10115	COG0037	tRNA processing
LEO77_RS10120	COG0589	response to stress
LEO77_RS10125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEO77_RS10140	COG2217	Heavy metal translocating P-type atpase
LEO77_RS10150	COG2010	Cytochrome c
LEO77_RS10165	COG3278	Belongs to the heme-copper respiratory oxidase family
LEO77_RS10175	COG1956	GAF domain-containing protein
LEO77_RS10180	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LEO77_RS10185	COG0793	Belongs to the peptidase S41A family
LEO77_RS10190	COG0308	aminopeptidase N
LEO77_RS10200	COG2902	Dehydrogenase
LEO77_RS10205	COG0167	dihydroorotate dehydrogenase activity
LEO77_RS10215	COG0254	rRNA binding
LEO77_RS10220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LEO77_RS10225	COG0116	Belongs to the methyltransferase superfamily
LEO77_RS10225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEO77_RS10235	COG0488	(ABC) transporter
LEO77_RS10245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEO77_RS10250	COG1067	ATP-dependent peptidase activity
LEO77_RS10290	COG4128	Pfam Zonular occludens toxin
LEO77_RS10325	COG3141	response to X-ray
LEO77_RS10330	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LEO77_RS10335	COG4221	oxidoreductase activity
LEO77_RS10380	COG0372	Belongs to the citrate synthase family
LEO77_RS10385	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LEO77_RS10395	COG2995	paraquat-inducible protein a
LEO77_RS10400	COG3008	intermembrane lipid transfer
LEO77_RS10405	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LEO77_RS10405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO77_RS10420	COG0084	hydrolase, TatD family'
LEO77_RS10425	COG0470	DNA polymerase III
LEO77_RS10430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LEO77_RS10435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LEO77_RS10440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LEO77_RS10445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LEO77_RS10450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LEO77_RS10455	COG1028	Short-chain dehydrogenase reductase Sdr
LEO77_RS10465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEO77_RS10470	COG0416	fatty acid biosynthetic process
LEO77_RS10475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LEO77_RS10480	COG1399	metal-binding, possibly nucleic acid-binding protein
LEO77_RS10485	COG0424	maF-like protein
LEO77_RS10500	COG1530	ribonuclease E activity
LEO77_RS10505	COG0306	phosphate transporter
LEO77_RS10510	COG0717	Belongs to the dCTP deaminase family
LEO77_RS10515	COG0572	uridine kinase
LEO77_RS10520	COG0489	protein tyrosine kinase activity
LEO77_RS10525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO77_RS10525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO77_RS10535	COG1254	Belongs to the acylphosphatase family
LEO77_RS10540	COG0840	transmembrane signaling receptor activity
LEO77_RS10545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LEO77_RS10555	COG0709	Synthesizes selenophosphate from selenide and ATP
LEO77_RS10560	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LEO77_RS10565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LEO77_RS10575	COG0318	PFAM AMP-dependent synthetase and ligase
LEO77_RS10580	COG2267	carboxylic ester hydrolase activity
LEO77_RS10590	COG1214	PFAM Peptidase M22, glycoprotease
LEO77_RS10595	COG1199	ATP-dependent helicase activity
LEO77_RS10605	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LEO77_RS10610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LEO77_RS10615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LEO77_RS10620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LEO77_RS10620	COG0131	Imidazoleglycerol-phosphate dehydratase
LEO77_RS10625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LEO77_RS10630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LEO77_RS10635	COG0107	imidazoleglycerol-phosphate synthase activity
LEO77_RS10650	COG2199	diguanylate cyclase activity
LEO77_RS10655	COG0318	PFAM AMP-dependent synthetase and ligase
LEO77_RS10660	COG1288	antiporter activity
LEO77_RS10675	COG3134	Outer membrane lipoprotein
LEO77_RS10680	COG2080	2 iron, 2 sulfur cluster binding
LEO77_RS10685	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LEO77_RS10690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LEO77_RS10695	COG2252	PERMEase
LEO77_RS10700	COG0402	S-adenosylhomocysteine deaminase activity
LEO77_RS10705	COG2233	PERMEase
LEO77_RS10710	COG2080	2 iron, 2 sulfur cluster binding
LEO77_RS10710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LEO77_RS10715	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LEO77_RS10720	COG0402	S-adenosylhomocysteine deaminase activity
LEO77_RS10725	COG0493	'glutamate synthase
LEO77_RS10725	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO77_RS10730	COG2068	MobA-Related Protein
LEO77_RS10735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LEO77_RS10740	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LEO77_RS10740	COG3608	succinylglutamate desuccinylase aspartoacylase
LEO77_RS10750	COG0697	spore germination
LEO77_RS10755	COG0549	Belongs to the carbamate kinase family
LEO77_RS10765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LEO77_RS10770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LEO77_RS10775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LEO77_RS10805	COG0242	peptide deformylase activity
LEO77_RS10815	COG0693	protein deglycase activity
LEO77_RS10825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LEO77_RS10830	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LEO77_RS10835	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LEO77_RS10845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LEO77_RS10850	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LEO77_RS10860	COG0205	6-phosphofructokinase activity
LEO77_RS10870	COG3123	guanosine phosphorylase activity
LEO77_RS10875	COG1760	l-serine dehydratase
LEO77_RS10880	COG1760	l-serine dehydratase
LEO77_RS10885	COG3100	YcgL domain-containing protein
LEO77_RS10890	COG0850	regulation of cytokinetic process
LEO77_RS10895	COG2894	cell division
LEO77_RS10900	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LEO77_RS10905	COG3099	Belongs to the UPF0263 family
LEO77_RS10910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEO77_RS10960	COG0697	spore germination
LEO77_RS10965	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LEO77_RS10970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO77_RS10990	COG2925	Exonuclease
LEO77_RS11000	COG3345	alpha-galactosidase
LEO77_RS11005	COG1380	Effector of murein hydrolase LrgA
LEO77_RS11010	COG1346	cytolysis
LEO77_RS11015	COG0295	cytidine deaminase activity
LEO77_RS11020	COG3033	Beta-eliminating lyase
LEO77_RS11030	COG3046	protein related to deoxyribodipyrimidine photolyase
LEO77_RS11035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LEO77_RS11040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEO77_RS11065	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO77_RS11075	COG3158	transport of potassium into the cell
LEO77_RS11080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO77_RS11085	COG0651	ATP synthesis coupled electron transport
LEO77_RS11090	COG0650	Formate hydrogenlyase subunit 4
LEO77_RS11095	COG3261	NADH dehydrogenase
LEO77_RS11095	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LEO77_RS11100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO77_RS11105	COG3260	NADH ubiquinone oxidoreductase 20
LEO77_RS11115	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LEO77_RS11125	COG1921	L-seryl-tRNASec selenium transferase activity
LEO77_RS11135	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LEO77_RS11140	COG0298	carbon dioxide binding
LEO77_RS11150	COG0309	Hydrogenase expression formation protein (HypE)
LEO77_RS11155	COG0375	protein maturation
LEO77_RS11165	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LEO77_RS11170	COG3842	ATPase activity
LEO77_RS11180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LEO77_RS11185	COG0601	transmembrane transport
LEO77_RS11195	COG1773	rubredoxin
LEO77_RS11200	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LEO77_RS11205	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LEO77_RS11210	COG5557	Pfam Polysulphide reductase, NrfD
LEO77_RS11215	COG0437	4 iron, 4 sulfur cluster binding
LEO77_RS11220	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LEO77_RS11225	COG0438	transferase activity, transferring glycosyl groups
LEO77_RS11230	COG0297	glycogen (starch) synthase activity
LEO77_RS11250	COG0438	transferase activity, transferring glycosyl groups
LEO77_RS11295	COG0438	transferase activity, transferring glycosyl groups
LEO77_RS11300	COG1215	transferase activity, transferring glycosyl groups
LEO77_RS11305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEO77_RS11350	COG0784	Response regulator, receiver
LEO77_RS11350	COG2205	protein histidine kinase activity
LEO77_RS11360	COG0730	response to heat
LEO77_RS11370	COG1028	Short-chain dehydrogenase reductase Sdr
LEO77_RS11380	COG1024	Enoyl-CoA hydratase
LEO77_RS11385	COG1024	Enoyl-CoA hydratase
LEO77_RS11390	COG1960	acyl-CoA dehydrogenase activity
LEO77_RS11395	COG1960	acyl-CoA dehydrogenase activity
LEO77_RS11400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LEO77_RS11405	COG1024	Enoyl-CoA hydratase
LEO77_RS11435	COG1584	GPR1 FUN34 yaaH family protein
LEO77_RS11450	COG1115	amino acid carrier protein
LEO77_RS11455	COG1024	Enoyl-CoA hydratase
LEO77_RS11470	COG3162	membrane
LEO77_RS11475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEO77_RS11480	COG0488	(ABC) transporter
LEO77_RS11485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEO77_RS11490	COG0776	regulation of translation
LEO77_RS11495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LEO77_RS11500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LEO77_RS11505	COG0740	serine-type endopeptidase activity
LEO77_RS11510	COG0544	peptidyl-prolyl cis-trans isomerase activity
LEO77_RS11520	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LEO77_RS11525	COG4591	ABC-type transport system involved in lipoprotein release permease component
LEO77_RS11530	COG1136	(ABC) transporter
LEO77_RS11535	COG4591	ABC-type transport system involved in lipoprotein release permease component
LEO77_RS11545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LEO77_RS11550	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LEO77_RS11555	COG4166	transmembrane transport
LEO77_RS11560	COG0697	spore germination
LEO77_RS11570	COG2062	phosphohistidine phosphatase, SixA
LEO77_RS11575	COG1025	Belongs to the peptidase M16 family
LEO77_RS11590	COG0596	Alpha beta hydrolase
LEO77_RS11610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LEO77_RS11615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LEO77_RS11615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LEO77_RS11620	COG0527	aspartate kinase activity
LEO77_RS11630	COG1368	sulfuric ester hydrolase activity
LEO77_RS11635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO77_RS11640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LEO77_RS11645	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LEO77_RS11685	COG0672	)-iron permease
LEO77_RS11710	COG2814	Major facilitator Superfamily
LEO77_RS11725	COG1136	(ABC) transporter
LEO77_RS11730	COG0577	efflux transmembrane transporter activity
LEO77_RS11760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LEO77_RS11760	COG0519	Catalyzes the synthesis of GMP from XMP
LEO77_RS11765	COG0516	GMP reductase activity
LEO77_RS11765	COG0517	IMP dehydrogenase activity
LEO77_RS11775	COG0366	Alpha amylase catalytic
LEO77_RS11775	COG1874	Beta-galactosidase
LEO77_RS11780	COG1570	exodeoxyribonuclease VII activity
LEO77_RS11785	COG2188	Transcriptional regulator
LEO77_RS11790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO77_RS11790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO77_RS11790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO77_RS11795	COG0383	alpha-mannosidase activity
LEO77_RS11800	COG1181	Belongs to the D-alanine--D-alanine ligase family
LEO77_RS11810	COG0386	Belongs to the glutathione peroxidase family
LEO77_RS11815	COG0513	Belongs to the DEAD box helicase family
LEO77_RS11830	COG1619	proteins homologs of microcin C7 resistance protein MccF
LEO77_RS11835	COG4667	esterase of the alpha-beta hydrolase superfamily
LEO77_RS11855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO77_RS11855	COG1648	precorrin-2 dehydrogenase activity
LEO77_RS11860	COG0393	Putative heavy-metal-binding
LEO77_RS11865	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LEO77_RS11870	COG0285	dihydrofolate synthase activity
LEO77_RS11875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LEO77_RS11880	COG0101	tRNA pseudouridine synthase activity
LEO77_RS11890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LEO77_RS11895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LEO77_RS11900	COG0671	phosphoesterase, PA-phosphatase related
LEO77_RS11905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LEO77_RS11910	COG2056	Na+-H+ antiporter family
LEO77_RS11915	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO77_RS11920	COG1360	Flagellar Motor Protein
LEO77_RS11925	COG4771	TonB-dependent receptor
LEO77_RS11930	COG1770	oligopeptidase
LEO77_RS11950	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO77_RS11955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO77_RS11960	COG0649	NAD binding
LEO77_RS11960	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO77_RS11975	COG1034	ATP synthesis coupled electron transport
LEO77_RS11980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LEO77_RS11985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO77_RS11990	COG0839	Belongs to the complex I subunit 6 family
LEO77_RS11995	COG0713	ATP synthesis coupled electron transport
LEO77_RS12005	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO77_RS12010	COG1007	ATP synthesis coupled electron transport
LEO77_RS12025	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO77_RS12025	COG2199	diguanylate cyclase activity
LEO77_RS12030	COG0047	phosphoribosylformylglycinamidine synthase activity
LEO77_RS12030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LEO77_RS12035	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LEO77_RS12040	COG1645	bacterial-type flagellum-dependent swarming motility
LEO77_RS12045	COG1160	GTP binding
LEO77_RS12050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO77_RS12055	COG2976	Protein conserved in bacteria
LEO77_RS12060	COG0124	histidyl-tRNA synthetase
LEO77_RS12065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LEO77_RS12080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LEO77_RS12085	COG0105	UTP biosynthetic process
LEO77_RS12100	COG0633	Ferredoxin
LEO77_RS12105	COG0443	Heat shock 70 kDa protein
LEO77_RS12110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LEO77_RS12120	COG0822	iron-sulfur transferase activity
LEO77_RS12125	COG1104	cysteine desulfurase activity
LEO77_RS12145	COG3154	lipid carrier protein
LEO77_RS12150	COG0826	peptidase U32
LEO77_RS12155	COG0826	peptidase U32
LEO77_RS12160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LEO77_RS12160	COG0574	Belongs to the PEP-utilizing enzyme family
LEO77_RS12165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LEO77_RS12200	COG0840	transmembrane signaling receptor activity
LEO77_RS12205	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEO77_RS12205	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LEO77_RS12210	COG0509	glycine decarboxylation via glycine cleavage system
LEO77_RS12215	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LEO77_RS12225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO77_RS12230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LEO77_RS12260	COG2814	Major facilitator Superfamily
LEO77_RS12265	COG0625	glutathione transferase activity
LEO77_RS12275	COG0483	inositol monophosphate 1-phosphatase activity
LEO77_RS12285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LEO77_RS12300	COG1086	Polysaccharide biosynthesis protein
LEO77_RS12305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO77_RS12310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LEO77_RS12320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO77_RS12345	COG0367	asparagine synthase
LEO77_RS12370	COG1215	transferase activity, transferring glycosyl groups
LEO77_RS12385	COG0318	PFAM AMP-dependent synthetase and ligase
LEO77_RS12390	COG1028	Short-chain dehydrogenase reductase Sdr
LEO77_RS12405	COG1083	cytidylyl-transferase
LEO77_RS12415	COG2089	acid synthase
LEO77_RS12435	COG4310	Domain of unknown function (DUF2172)
LEO77_RS12505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO77_RS12505	COG0301	tRNA thio-modification
LEO77_RS12515	COG4953	penicillin-binding protein 1C
LEO77_RS12520	COG2373	Large extracellular alpha-helical protein
LEO77_RS12530	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO77_RS12535	COG5001	Diguanylate cyclase
LEO77_RS12535	COG3300	MHYT domain
LEO77_RS12540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO77_RS12550	COG1252	NADH dehydrogenase
LEO77_RS12560	COG2233	PERMEase
LEO77_RS12570	COG2354	Protein conserved in bacteria
LEO77_RS12585	COG0840	transmembrane signaling receptor activity
LEO77_RS12590	COG1301	dicarboxylic acid transport
LEO77_RS12605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LEO77_RS12620	COG0537	adenosine 5'-monophosphoramidase activity
LEO77_RS12655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO77_RS12660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LEO77_RS12670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO77_RS12675	COG1605	Chorismate mutase
LEO77_RS12675	COG0287	Prephenate dehydrogenase
LEO77_RS12685	COG1199	ATP-dependent helicase activity
LEO77_RS12695	COG0123	including yeast histone deacetylase and acetoin utilization protein
LEO77_RS12700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LEO77_RS12705	COG1785	Belongs to the alkaline phosphatase family
LEO77_RS12725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LEO77_RS12730	COG2197	response regulator
LEO77_RS12745	COG3706	GGDEF domain
LEO77_RS12750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO77_RS12755	COG0765	amino acid transport
LEO77_RS12760	COG1126	abc transporter atp-binding protein
LEO77_RS12775	COG0531	amino acid
LEO77_RS12790	COG1253	flavin adenine dinucleotide binding
LEO77_RS12795	COG0704	Plays a role in the regulation of phosphate uptake
LEO77_RS12800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LEO77_RS12805	COG0581	inorganic phosphate transmembrane transporter activity
LEO77_RS12810	COG0573	inorganic phosphate transmembrane transporter activity
LEO77_RS12815	COG0590	tRNA wobble adenosine to inosine editing
LEO77_RS12830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LEO77_RS12850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LEO77_RS12855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LEO77_RS12860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LEO77_RS12865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LEO77_RS12890	COG2716	regulation of RNA biosynthetic process
LEO77_RS12895	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LEO77_RS12905	COG2239	Acts as a magnesium transporter
LEO77_RS12910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LEO77_RS12920	COG1705	Flagellar rod assembly protein muramidase FlgJ
LEO77_RS12920	COG3951	Flagellar rod assembly protein muramidase FlgJ
LEO77_RS12925	COG1706	bacterial-type flagellum-dependent cell motility
LEO77_RS12930	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LEO77_RS12940	COG4787	bacterial-type flagellum-dependent cell motility
LEO77_RS12950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LEO77_RS12960	COG1815	bacterial-type flagellum-dependent cell motility
LEO77_RS12965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LEO77_RS12970	COG0784	Response regulator, receiver
LEO77_RS12970	COG0835	chemotaxis
LEO77_RS12975	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LEO77_RS12990	COG0622	Phosphoesterase
LEO77_RS12995	COG4166	transmembrane transport
LEO77_RS13005	COG1187	pseudouridine synthase activity
LEO77_RS13020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LEO77_RS13025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO77_RS13030	COG1882	Formate acetyltransferase
LEO77_RS13035	COG1349	DNA-binding transcription factor activity
LEO77_RS13040	COG0697	spore germination
LEO77_RS13045	COG4166	transmembrane transport
LEO77_RS13075	COG1278	Cold shock
LEO77_RS13100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LEO77_RS13100	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LEO77_RS13105	COG1028	Short-chain dehydrogenase reductase Sdr
LEO77_RS13110	COG1535	isochorismatase
LEO77_RS13110	COG3433	isochorismatase activity
LEO77_RS13115	COG1021	2,3-dihydroxybenzoate-AMP ligase
LEO77_RS13120	COG1169	isochorismate synthase
LEO77_RS13125	COG4771	TonB-dependent receptor
LEO77_RS13130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LEO77_RS13135	COG1609	Transcriptional regulator
LEO77_RS13140	COG0741	lytic transglycosylase activity
LEO77_RS13150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LEO77_RS13170	COG2911	Protein conserved in bacteria
LEO77_RS13175	COG0729	surface antigen
LEO77_RS13185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LEO77_RS13195	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LEO77_RS13205	COG4134	Bacterial extracellular solute-binding protein
LEO77_RS13215	COG4136	ATPase activity
LEO77_RS13220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LEO77_RS13225	COG2951	lytic endotransglycosylase activity
LEO77_RS13230	COG0033	Phosphoglucomutase
LEO77_RS13235	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LEO77_RS13240	COG0596	Alpha beta hydrolase
LEO77_RS13255	COG0716	FMN binding
LEO77_RS13265	COG0735	belongs to the Fur family
LEO77_RS13270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO77_RS13280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO77_RS13280	COG1263	PTS System
LEO77_RS13280	COG2190	(PTS) system
LEO77_RS13285	COG0363	glucosamine-6-phosphate deaminase activity
LEO77_RS13290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LEO77_RS13295	COG1846	Transcriptional regulator
LEO77_RS13295	COG1940	carbohydrate kinase activity
LEO77_RS13305	COG2199	diguanylate cyclase activity
LEO77_RS13305	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LEO77_RS13310	COG3275	phosphorelay sensor kinase activity
LEO77_RS13315	COG3279	Response regulator of the LytR AlgR family
LEO77_RS13320	COG1966	Carbon starvation protein
LEO77_RS13330	COG1566	PFAM secretion protein HlyD family protein
LEO77_RS13335	COG1061	Type III restriction enzyme res subunit
LEO77_RS13340	COG2027	D-alanyl-D-alanine carboxypeptidase
LEO77_RS13345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LEO77_RS13350	COG3021	interspecies interaction between organisms
LEO77_RS13360	COG1607	acyl-coa hydrolase
LEO77_RS13365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO77_RS13375	COG0674	pyruvate-flavodoxin oxidoreductase activity
LEO77_RS13375	COG1013	pyruvate-flavodoxin oxidoreductase activity
LEO77_RS13375	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LEO77_RS13375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LEO77_RS13390	COG0633	Ferredoxin
LEO77_RS13390	COG3217	Mosc domain protein beta barrel domain protein
LEO77_RS13390	COG0633	Ferredoxin
LEO77_RS13390	COG3217	Mosc domain protein beta barrel domain protein
LEO77_RS13395	COG0840	transmembrane signaling receptor activity
LEO77_RS13400	COG0501	Belongs to the peptidase M48B family
LEO77_RS13405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LEO77_RS13410	COG2226	methyltransferase
LEO77_RS13410	COG1073	alpha beta
LEO77_RS13415	COG0156	8-amino-7-oxononanoate synthase activity
LEO77_RS13420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEO77_RS13425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LEO77_RS13440	COG0017	Asparaginyl-tRNA synthetase
LEO77_RS13455	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LEO77_RS13470	COG3069	C4-dicarboxylate transmembrane transporter activity
LEO77_RS13480	COG1393	Belongs to the ArsC family
LEO77_RS13485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LEO77_RS13490	COG1876	peptidase activity
LEO77_RS13500	COG3263	regulation of cellular component size
LEO77_RS13515	COG1280	lysine exporter protein (LysE YggA)
LEO77_RS13545	COG0564	pseudouridine synthase activity
LEO77_RS13555	COG1454	alcohol dehydrogenase
LEO77_RS13560	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LEO77_RS13565	COG0702	epimerase
LEO77_RS13575	COG0095	Lipoate-protein ligase
LEO77_RS13590	COG0577	efflux transmembrane transporter activity
LEO77_RS13590	COG1136	(ABC) transporter
LEO77_RS13595	COG0577	efflux transmembrane transporter activity
LEO77_RS13595	COG1136	(ABC) transporter
LEO77_RS13600	COG1566	PFAM secretion protein HlyD family protein
LEO77_RS13640	COG1285	pathogenesis
LEO77_RS13670	COG2239	Acts as a magnesium transporter
LEO77_RS13675	COG0484	heat shock protein binding
LEO77_RS13680	COG0443	Heat shock 70 kDa protein
LEO77_RS13685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LEO77_RS13690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LEO77_RS13695	COG0497	DNA recombination
LEO77_RS13700	COG1227	inorganic diphosphatase activity
LEO77_RS13705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO77_RS13710	COG0577	efflux transmembrane transporter activity
LEO77_RS13710	COG1136	(ABC) transporter
LEO77_RS13730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEO77_RS13740	COG0297	glycogen (starch) synthase activity
LEO77_RS13745	COG0463	Glycosyl transferase, family 2
LEO77_RS13745	COG1216	Glycosyl transferase, family 2
LEO77_RS13760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LEO77_RS13775	COG1051	belongs to the nudix hydrolase family
LEO77_RS13805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LEO77_RS13810	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LEO77_RS13815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEO77_RS13835	COG1091	dTDP-4-dehydrorhamnose reductase activity
LEO77_RS13845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO77_RS13850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO77_RS13855	COG1309	transcriptional regulator
LEO77_RS13870	COG1342	Belongs to the UPF0251 family
LEO77_RS13920	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO77_RS13925	COG1773	rubredoxin
LEO77_RS13925	COG0426	domain, Protein
LEO77_RS13930	COG3604	Transcriptional regulator
LEO77_RS13935	COG2197	response regulator
LEO77_RS13950	COG2199	diguanylate cyclase activity
LEO77_RS13950	COG2203	Gaf domain
LEO77_RS13955	COG2203	Gaf domain
LEO77_RS13955	COG2199	diguanylate cyclase activity
LEO77_RS13960	COG5642	Protein of unknown function (DUF2384)
LEO77_RS13970	COG2916	Histone family protein nucleoid-structuring protein H-NS
LEO77_RS13985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LEO77_RS13985	COG0426	domain, Protein
LEO77_RS14010	COG3621	Patatin-like phospholipase
LEO77_RS14035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LEO77_RS14050	COG0813	purine-nucleoside phosphorylase activity
LEO77_RS14065	COG1376	ErfK ybiS ycfS ynhG family protein
LEO77_RS14065	COG1388	LysM domain
LEO77_RS14075	COG0471	metal ion transport
LEO77_RS14085	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LEO77_RS14090	COG0791	NLP P60 protein
LEO77_RS14110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LEO77_RS14115	COG0788	formyltetrahydrofolate deformylase activity
LEO77_RS14125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO77_RS14140	COG0741	lytic transglycosylase activity
LEO77_RS14140	COG1196	nuclear chromosome segregation
LEO77_RS14140	COG0739	heme binding
LEO77_RS14145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LEO77_RS14155	COG0436	Aminotransferase
LEO77_RS14160	COG1288	antiporter activity
LEO77_RS14165	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LEO77_RS14175	COG2964	Protein conserved in bacteria
LEO77_RS14180	COG3681	Belongs to the UPF0597 family
LEO77_RS14190	COG0814	amino acid
LEO77_RS14210	COG1166	arginine decarboxylase activity
LEO77_RS14215	COG2195	Cleaves the N-terminal amino acid of tripeptides
LEO77_RS14230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LEO77_RS14240	COG2353	YceI-like domain
LEO77_RS14245	COG0583	DNA-binding transcription factor activity
LEO77_RS14255	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LEO77_RS14260	COG0840	transmembrane signaling receptor activity
LEO77_RS14265	COG0302	gtp cyclohydrolase
LEO77_RS14275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LEO77_RS14280	COG2267	carboxylic ester hydrolase activity
LEO77_RS14285	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LEO77_RS14300	COG0314	molybdopterin synthase activity
LEO77_RS14305	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LEO77_RS14310	COG0315	cyclic pyranopterin monophosphate synthase activity
LEO77_RS14315	COG0521	Mo-molybdopterin cofactor biosynthetic process
LEO77_RS14320	COG3005	denitrification pathway
LEO77_RS14330	COG0348	domain, Protein
LEO77_RS14335	COG0437	4 iron, 4 sulfur cluster binding
LEO77_RS14340	COG0243	molybdopterin cofactor binding
LEO77_RS14350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LEO77_RS14355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LEO77_RS14360	COG3850	Histidine kinase
LEO77_RS14365	COG2197	response regulator
LEO77_RS14395	COG0121	glutamine amidotransferase
LEO77_RS14400	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LEO77_RS14405	COG1960	acyl-CoA dehydrogenase activity
LEO77_RS14410	COG1473	amidohydrolase
LEO77_RS14415	COG2914	Belongs to the UPF0125 (RnfH) family
LEO77_RS14420	COG2867	negative regulation of translational initiation
LEO77_RS14425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LEO77_RS14480	COG0582	viral genome integration into host DNA
LEO77_RS14490	COG0582	viral genome integration into host DNA
LEO77_RS14515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LEO77_RS14530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LEO77_RS14540	COG1401	restriction endodeoxyribonuclease activity
LEO77_RS14570	COG3383	formate dehydrogenase (NAD+) activity
LEO77_RS14580	COG2814	Major facilitator Superfamily
LEO77_RS14580	COG0477	Major facilitator Superfamily
LEO77_RS14585	COG0457	Tetratricopeptide repeat
LEO77_RS14590	COG1940	carbohydrate kinase activity
LEO77_RS14605	COG3311	Transcriptional regulator
LEO77_RS14675	COG2003	Belongs to the UPF0758 family
LEO77_RS14750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LEO77_RS14755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LEO77_RS14770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LEO77_RS14780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LEO77_RS14790	COG1960	acyl-CoA dehydrogenase activity
LEO77_RS14795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO77_RS14805	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LEO77_RS14820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LEO77_RS14825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO77_RS14825	COG1263	PTS System
LEO77_RS14830	COG1609	Transcriptional regulator
LEO77_RS14855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO77_RS14855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO77_RS14855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO77_RS14860	COG2271	Major facilitator Superfamily
LEO77_RS14865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LEO77_RS14875	COG1187	pseudouridine synthase activity
LEO77_RS14885	COG0482	sulfurtransferase activity
LEO77_RS14890	COG2915	High frequency lysogenization protein hflD homolog
LEO77_RS14895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LEO77_RS14900	COG2850	peptidyl-arginine hydroxylation
LEO77_RS14925	COG0259	pyridoxamine-phosphate oxidase activity
LEO77_RS14950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LEO77_RS14950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO77_RS14960	COG1882	Formate acetyltransferase
LEO77_RS14965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LEO77_RS14975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LEO77_RS14980	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LEO77_RS15005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LEO77_RS15010	COG1138	Cytochrome C-type biogenesis protein
LEO77_RS15015	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LEO77_RS15020	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO77_RS15025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO77_RS15030	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LEO77_RS15045	COG0835	chemotaxis
LEO77_RS15055	COG1192	Involved in chromosome partitioning
LEO77_RS15060	COG1360	Flagellar Motor Protein
LEO77_RS15065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO77_RS15070	COG2201	protein-glutamate methylesterase activity
LEO77_RS15075	COG2198	Histidine kinase
LEO77_RS15075	COG0643	Histidine kinase
LEO77_RS15075	COG0784	Response regulator, receiver
LEO77_RS15080	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LEO77_RS15105	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LEO77_RS15115	COG1684	flagellar biosynthetic protein fliR
LEO77_RS15120	COG1987	bacterial-type flagellum assembly
LEO77_RS15170	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LEO77_RS15180	COG1677	Flagellar hook-basal body complex protein FliE
LEO77_RS15185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LEO77_RS15190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO77_RS15195	COG3706	GGDEF domain
LEO77_RS15200	COG1752	Esterase of the alpha-beta hydrolase superfamily
LEO77_RS15205	COG0531	amino acid
LEO77_RS15235	COG0281	malic enzyme
LEO77_RS15245	COG0534	Mate efflux family protein
LEO77_RS15260	COG2233	PERMEase
LEO77_RS15265	COG0095	Lipoate-protein ligase
LEO77_RS15270	COG1115	amino acid carrier protein
LEO77_RS15275	COG0019	diaminopimelate decarboxylase activity
LEO77_RS15285	COG0678	peroxiredoxin activity
LEO77_RS15295	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LEO77_RS15310	COG0545	Peptidyl-prolyl cis-trans isomerase
LEO77_RS15315	COG3142	Participates in the control of copper homeostasis
LEO77_RS15340	COG5002	protein histidine kinase activity
LEO77_RS15345	COG0745	RESPONSE REGULATOR receiver
LEO77_RS15350	COG0346	lactoylglutathione lyase activity
LEO77_RS15355	COG3706	GGDEF domain
LEO77_RS15365	COG0697	spore germination
LEO77_RS15375	COG3290	protein histidine kinase activity
LEO77_RS15380	COG0281	malic enzyme
LEO77_RS15395	COG1846	Transcriptional regulator
LEO77_RS15400	COG1566	PFAM secretion protein HlyD family protein
LEO77_RS15430	COG0602	queuosine metabolic process
LEO77_RS15435	COG1328	CTP reductase activity
LEO77_RS15450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LEO77_RS15465	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LEO77_RS15470	COG2912	Transglutaminase-like superfamily
LEO77_RS15480	COG2890	protein-(glutamine-N5) methyltransferase activity
LEO77_RS15485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LEO77_RS15490	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LEO77_RS15495	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LEO77_RS15500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LEO77_RS15510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LEO77_RS15515	COG0737	Belongs to the 5'-nucleotidase family
LEO77_RS15520	COG0193	aminoacyl-tRNA hydrolase activity
LEO77_RS15525	COG0012	GTP binding
LEO77_RS15570	COG0490	domain, Protein
LEO77_RS15570	COG0471	metal ion transport
LEO77_RS15585	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LEO77_RS15605	COG0366	Alpha amylase catalytic
LEO77_RS15610	COG0674	pyruvate-flavodoxin oxidoreductase activity
LEO77_RS15610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LEO77_RS15610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LEO77_RS15610	COG1013	pyruvate-flavodoxin oxidoreductase activity
LEO77_RS15620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO77_RS15630	COG0251	oxidation-reduction process
LEO77_RS15645	COG0583	DNA-binding transcription factor activity
LEO77_RS15650	COG3321	synthase
LEO77_RS15650	COG1028	Short-chain dehydrogenase reductase Sdr
LEO77_RS15650	COG0604	alcohol dehydrogenase
LEO77_RS15660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LEO77_RS15670	COG3091	SprT-like family
LEO77_RS15680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LEO77_RS15685	COG0189	ligase activity
LEO77_RS15690	COG1678	Uncharacterized ACR, COG1678
LEO77_RS15695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LEO77_RS15700	COG3104	oligopeptide transport
LEO77_RS15715	COG0714	Associated with various cellular activities
LEO77_RS15730	COG1115	amino acid carrier protein
LEO77_RS15735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LEO77_RS15745	COG0825	malonyl-CoA metabolic process
LEO77_RS15755	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LEO77_RS15760	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO77_RS15765	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO77_RS15770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LEO77_RS15775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LEO77_RS15790	COG0750	zinc metalloprotease
LEO77_RS15795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LEO77_RS15800	COG0575	Belongs to the CDS family
LEO77_RS15805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LEO77_RS15810	COG0233	cytoplasmic translational termination
LEO77_RS15815	COG0528	UMP kinase activity
LEO77_RS15820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LEO77_RS15825	COG0052	Belongs to the universal ribosomal protein uS2 family
LEO77_RS15830	COG0024	Methionine aminopeptidase
LEO77_RS15835	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LEO77_RS15840	COG2171	N-acyltransferase activity
LEO77_RS15850	COG1263	PTS System
LEO77_RS15850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO77_RS15860	COG4580	involved in the transport of maltose and maltodextrins
LEO77_RS15870	COG0564	pseudouridine synthase activity
LEO77_RS15875	COG3098	single-species biofilm formation
LEO77_RS15900	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LEO77_RS15910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LEO77_RS15910	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LEO77_RS15925	COG1611	Belongs to the LOG family
LEO77_RS15930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LEO77_RS15935	COG0473	3-isopropylmalate dehydrogenase activity
LEO77_RS15945	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LEO77_RS15950	COG2363	Small membrane protein
LEO77_RS15960	COG0583	DNA-binding transcription factor activity
LEO77_RS15965	COG0840	transmembrane signaling receptor activity
LEO77_RS15970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LEO77_RS15985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LEO77_RS15990	COG1666	GTP binding
LEO77_RS15995	COG3248	Nucleoside-binding outer membrane protein
LEO77_RS16000	COG2211	Major facilitator Superfamily
LEO77_RS16005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LEO77_RS16015	COG2813	Specifically methylates the guanine in position
LEO77_RS16020	COG0271	Belongs to the BolA IbaG family
LEO77_RS16025	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO77_RS16030	COG1805	sodium ion transport
LEO77_RS16035	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO77_RS16040	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO77_RS16045	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LEO77_RS16050	COG2871	sodium ion transport
LEO77_RS16055	COG1477	protein flavinylation
LEO77_RS16085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LEO77_RS16100	COG0300	oxidoreductase activity
LEO77_RS16110	COG0415	Belongs to the DNA photolyase family
LEO77_RS16115	COG0789	Transcriptional regulator
LEO77_RS16120	COG3272	Protein of unknown function (DUF1722)
LEO77_RS16150	COG1605	Chorismate mutase
LEO77_RS16150	COG0077	Prephenate dehydratase
LEO77_RS16170	COG0784	Response regulator, receiver
LEO77_RS16170	COG0835	chemotaxis
LEO77_RS16235	COG0300	oxidoreductase activity
LEO77_RS16260	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LEO77_RS16300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LEO77_RS16305	COG0826	peptidase U32
LEO77_RS16310	COG1280	lysine exporter protein (LysE YggA)
LEO77_RS16320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LEO77_RS16325	COG1185	polyribonucleotide nucleotidyltransferase activity
LEO77_RS16330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LEO77_RS16335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LEO77_RS16340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LEO77_RS16345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LEO77_RS16350	COG0195	Participates in both transcription termination and antitermination
LEO77_RS16355	COG0779	Required for maturation of 30S ribosomal subunits
LEO77_RS16370	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LEO77_RS16375	COG0149	triose-phosphate isomerase activity
LEO77_RS16380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LEO77_RS16385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LEO77_RS16395	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LEO77_RS16400	COG1534	Rna-binding protein
LEO77_RS16415	COG1360	Flagellar Motor Protein
LEO77_RS16415	COG1360	Flagellar Motor Protein
LEO77_RS16420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LEO77_RS16425	COG1722	exodeoxyribonuclease VII activity
LEO77_RS16430	COG0142	geranyltranstransferase activity
LEO77_RS16435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LEO77_RS16445	COG0601	transmembrane transport
LEO77_RS16460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LEO77_RS16465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LEO77_RS16470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LEO77_RS16475	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LEO77_RS16490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEO77_RS16490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LEO77_RS16495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LEO77_RS16500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LEO77_RS16510	COG2198	Histidine kinase
LEO77_RS16510	COG2205	protein histidine kinase activity
LEO77_RS16510	COG0784	Response regulator, receiver
LEO77_RS16515	COG1879	ABC-type sugar transport system periplasmic component
LEO77_RS16525	COG0745	RESPONSE REGULATOR receiver
LEO77_RS16530	COG3005	denitrification pathway
LEO77_RS16540	COG3381	protein complex oligomerization
LEO77_RS16570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEO77_RS16575	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LEO77_RS16580	COG0511	ligase activity, forming carbon-carbon bonds
LEO77_RS16585	COG0439	Biotin carboxylase
LEO77_RS16590	COG3924	membrane
LEO77_RS16595	COG4145	pantothenate transmembrane transporter activity
LEO77_RS16600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO77_RS16600	COG1263	PTS System
LEO77_RS16600	COG2190	(PTS) system
LEO77_RS16605	COG0583	DNA-binding transcription factor activity
LEO77_RS16610	COG0604	alcohol dehydrogenase
LEO77_RS16615	COG2264	protein methyltransferase activity
LEO77_RS16625	COG0778	Nitroreductase
LEO77_RS16630	COG1902	pentaerythritol trinitrate reductase activity
LEO77_RS16630	COG0446	pyridine nucleotide-disulphide oxidoreductase
LEO77_RS16635	COG0616	signal peptide processing
LEO77_RS16655	COG0848	biopolymer transport protein
LEO77_RS16660	COG0811	peptide transport
LEO77_RS16665	COG0811	peptide transport
LEO77_RS16680	COG4174	ABC transporter (Permease)
LEO77_RS16685	COG4239	(ABC) transporter, permease
LEO77_RS16695	COG0444	Belongs to the ABC transporter superfamily
LEO77_RS16700	COG4608	Belongs to the ABC transporter superfamily
LEO77_RS16715	COG3416	Protein conserved in bacteria
LEO77_RS16725	COG0741	lytic transglycosylase activity
LEO77_RS16730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LEO77_RS16735	COG0488	(ABC) transporter
LEO77_RS16745	COG2252	PERMEase
LEO77_RS16750	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LEO77_RS16770	COG0745	RESPONSE REGULATOR receiver
LEO77_RS16785	COG2816	NAD+ diphosphatase activity
LEO77_RS16830	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
LEO77_RS16840	COG0513	Belongs to the DEAD box helicase family
LEO77_RS16850	COG0471	metal ion transport
LEO77_RS16865	COG0154	amidase activity
LEO77_RS16870	COG2957	Belongs to the agmatine deiminase family
LEO77_RS16885	COG1902	pentaerythritol trinitrate reductase activity
LEO77_RS16900	COG1238	metal cluster binding
LEO77_RS16905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LEO77_RS16910	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LEO77_RS16915	COG0585	pseudouridine synthase activity
LEO77_RS16925	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LEO77_RS16930	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LEO77_RS16935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LEO77_RS16945	COG1376	ErfK ybiS ycfS ynhG family protein
LEO77_RS16950	COG0668	transmembrane transport
LEO77_RS16960	COG2731	YhcH YjgK YiaL family protein
LEO77_RS16970	COG1794	racemase activity, acting on amino acids and derivatives
LEO77_RS16985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LEO77_RS17005	COG0488	(ABC) transporter
LEO77_RS17015	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LEO77_RS17060	COG0789	Transcriptional regulator
LEO77_RS17075	COG0148	phosphopyruvate hydratase activity
LEO77_RS17080	COG0504	CTP synthase activity
LEO77_RS17085	COG3956	TIGRFAM MazG family protein
LEO77_RS17090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LEO77_RS17095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO77_RS17105	COG4807	Protein conserved in bacteria
LEO77_RS17110	COG3023	N-Acetylmuramoyl-L-alanine amidase
LEO77_RS17115	COG0783	Belongs to the Dps family
LEO77_RS17120	COG1151	hydroxylamine reductase activity
LEO77_RS17125	COG1017	nitric oxide dioxygenase activity
LEO77_RS17125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LEO77_RS17130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEO77_RS17135	COG0671	phosphoesterase, PA-phosphatase related
LEO77_RS17140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LEO77_RS17145	COG0163	prenyltransferase activity
LEO77_RS17160	COG1131	(ABC) transporter
LEO77_RS17165	COG0842	Transport permease protein
LEO77_RS17195	COG1823	symporter activity
LEO77_RS17205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LEO77_RS17210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LEO77_RS17215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LEO77_RS17225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LEO77_RS17230	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LEO77_RS17235	COG1489	DNA binding
LEO77_RS17245	COG1643	Atp-dependent helicase
LEO77_RS17250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LEO77_RS17255	COG0346	lactoylglutathione lyase activity
LEO77_RS17260	COG2076	Multidrug Resistance protein
LEO77_RS17265	COG2076	Multidrug Resistance protein
LEO77_RS17275	COG0784	Response regulator, receiver
LEO77_RS17275	COG3437	response regulator, receiver
LEO77_RS17280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LEO77_RS17295	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LEO77_RS17310	COG1136	(ABC) transporter
LEO77_RS17330	COG0840	transmembrane signaling receptor activity
LEO77_RS17350	COG0529	Catalyzes the synthesis of activated sulfate
LEO77_RS17355	COG0471	metal ion transport
LEO77_RS17355	COG3273	potassium ion transport
LEO77_RS17360	COG2895	sulfate adenylyltransferase (ATP) activity
LEO77_RS17365	COG0175	sulfate reduction
LEO77_RS17370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO77_RS17370	COG1648	precorrin-2 dehydrogenase activity
LEO77_RS17375	COG0330	HflC and HflK could
LEO77_RS17380	COG1585	Membrane protein implicated in regulation of membrane protease activity
LEO77_RS17385	COG0840	transmembrane signaling receptor activity
LEO77_RS17390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LEO77_RS17395	COG0676	glucose-6-phosphate 1-epimerase activity
LEO77_RS17400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LEO77_RS17405	COG1640	4-alpha-glucanotransferase
LEO77_RS17410	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LEO77_RS17460	COG0561	phosphatase activity
LEO77_RS17475	COG0733	neurotransmitter:sodium symporter activity
LEO77_RS17485	COG0733	neurotransmitter:sodium symporter activity
LEO77_RS17545	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LEO77_RS17550	COG2885	chlorophyll binding
LEO77_RS17555	COG0823	Involved in the tonB-independent uptake of proteins
LEO77_RS17570	COG0811	peptide transport
LEO77_RS17575	COG0824	Thioesterase
LEO77_RS17580	COG3790	cyd operon protein YbgE
LEO77_RS17585	COG4890	Cyd operon protein YbgT
LEO77_RS17590	COG1294	oxidase, subunit
LEO77_RS17600	COG2255	four-way junction helicase activity
LEO77_RS17605	COG0632	four-way junction helicase activity
LEO77_RS17620	COG2771	luxR family
LEO77_RS17635	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LEO77_RS17640	COG3706	GGDEF domain
LEO77_RS17640	COG2203	Gaf domain
LEO77_RS17640	COG5001	Diguanylate cyclase
LEO77_RS17640	COG4251	negative regulation of phosphorylation
LEO77_RS17650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LEO77_RS17660	COG2995	paraquat-inducible protein a
LEO77_RS17665	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LEO77_RS17665	COG3008	intermembrane lipid transfer
LEO77_RS17675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO77_RS17680	COG0442	prolyl-tRNA aminoacylation
LEO77_RS17685	COG4221	oxidoreductase activity
LEO77_RS17700	COG1024	Enoyl-CoA hydratase
LEO77_RS17710	COG0110	maltose O-acetyltransferase activity
LEO77_RS17720	COG4166	transmembrane transport
LEO77_RS17730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LEO77_RS17735	COG0735	belongs to the Fur family
LEO77_RS17760	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LEO77_RS17765	COG0513	Belongs to the DEAD box helicase family
LEO77_RS17770	COG2153	protein acetylation
LEO77_RS17780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LEO77_RS17795	COG3540	Alkaline phosphatase
LEO77_RS17800	COG0557	exoribonuclease II activity
LEO77_RS17805	COG3706	GGDEF domain
LEO77_RS17810	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LEO77_RS17810	COG2885	chlorophyll binding
LEO77_RS17815	COG3240	lipase activity
LEO77_RS17820	COG3111	PFAM Bacterial OB fold (BOF) protein
LEO77_RS17830	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LEO77_RS17835	COG1194	a g-specific adenine glycosylase
LEO77_RS17840	COG0617	tRNA 3'-terminal CCA addition
LEO77_RS17860	COG3068	Protein conserved in bacteria
LEO77_RS17870	COG0739	heme binding
LEO77_RS17890	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LEO77_RS17895	COG1121	(ABC) transporter
LEO77_RS17900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LEO77_RS17905	COG0583	DNA-binding transcription factor activity
LEO77_RS17910	COG0697	spore germination
LEO77_RS17915	COG1573	uracil-dna glycosylase
LEO77_RS17930	COG2827	Endonuclease containing a URI domain
LEO77_RS17945	COG1842	Phage shock protein A
LEO77_RS17950	COG0204	Acyl-transferase
LEO77_RS17995	COG3104	oligopeptide transport
LEO77_RS18015	COG0187	DNA topoisomerase II activity
LEO77_RS18025	COG3150	esterase
LEO77_RS18035	COG3151	Protein conserved in bacteria
LEO77_RS18040	COG0494	nUDIX hydrolase
LEO77_RS18045	COG1538	Outer membrane efflux protein
LEO77_RS18050	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LEO77_RS18050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LEO77_RS18055	COG1560	Kdo2-lipid A biosynthetic process
LEO77_RS18060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LEO77_RS18060	COG2213	PTS system mannitol-specific
LEO77_RS18065	COG0246	Mannitol dehydrogenase
LEO77_RS18070	COG3722	fumarate hydratase activity
LEO77_RS18080	COG0484	heat shock protein binding
LEO77_RS18100	COG1448	Aminotransferase
LEO77_RS18115	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LEO77_RS18120	COG1328	CTP reductase activity
LEO77_RS18135	COG0633	Ferredoxin
LEO77_RS18135	COG0543	2 iron, 2 sulfur cluster binding
LEO77_RS18165	COG0840	transmembrane signaling receptor activity
LEO77_RS18170	COG3397	chitin binding
LEO77_RS18175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO77_RS18180	COG1126	abc transporter atp-binding protein
LEO77_RS18190	COG0765	amino acid transport
LEO77_RS18195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LEO77_RS18200	COG0583	DNA-binding transcription factor activity
LEO77_RS18205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LEO77_RS18210	COG4208	sulfate ABC transporter
LEO77_RS18215	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LEO77_RS18225	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LEO77_RS18230	COG3174	membrane
LEO77_RS18235	COG0110	maltose O-acetyltransferase activity
LEO77_RS18250	COG1011	Hydrolase
LEO77_RS18255	COG0494	nUDIX hydrolase
LEO77_RS18260	COG1218	3'(2'),5'-bisphosphate nucleotidase
LEO77_RS18270	COG0814	amino acid
LEO77_RS18275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LEO77_RS18290	COG0626	cystathionine gamma-synthase activity
LEO77_RS18295	COG0460	homoserine dehydrogenase
LEO77_RS18295	COG0527	aspartate kinase activity
LEO77_RS18300	COG0306	phosphate transporter
LEO77_RS18305	COG1392	Phosphate transport regulator
LEO77_RS18315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LEO77_RS18320	COG2813	Specifically methylates the guanine in position
LEO77_RS18325	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LEO77_RS18330	COG0297	glycogen (starch) synthase activity
LEO77_RS18370	COG1757	Na H antiporter
LEO77_RS18375	COG0316	Belongs to the HesB IscA family
LEO77_RS18385	COG0038	chloride channel
LEO77_RS18390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LEO77_RS18405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LEO77_RS18405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LEO77_RS18435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LEO77_RS18440	COG0564	pseudouridine synthase activity
LEO77_RS18455	COG0110	maltose O-acetyltransferase activity
LEO77_RS18460	COG0366	Alpha amylase catalytic
LEO77_RS18465	COG1263	PTS System
LEO77_RS18465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO77_RS18485	COG0252	asparaginase activity
LEO77_RS18490	COG1253	flavin adenine dinucleotide binding
LEO77_RS18495	COG0586	Pfam SNARE associated Golgi protein
LEO77_RS18500	COG1686	Belongs to the peptidase S11 family
LEO77_RS18535	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LEO77_RS18540	COG0527	aspartate kinase activity
LEO77_RS18545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LEO77_RS18555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LEO77_RS18560	COG1546	Belongs to the CinA family
LEO77_RS18565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LEO77_RS18570	COG0628	permease
LEO77_RS18575	COG0494	nUDIX hydrolase
LEO77_RS18590	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LEO77_RS18595	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LEO77_RS18615	COG0456	acetyltransferase
LEO77_RS18620	COG3133	Outer membrane lipoprotein
LEO77_RS18625	COG0004	ammonium transporteR
LEO77_RS18630	COG3706	GGDEF domain
LEO77_RS18640	COG3932	Exopolysaccharide synthesis, ExoD
LEO77_RS18645	COG0814	amino acid
LEO77_RS18650	COG3706	GGDEF domain
LEO77_RS18660	COG0110	maltose O-acetyltransferase activity
LEO77_RS18665	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LEO77_RS18685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LEO77_RS18690	COG2022	thiamine diphosphate biosynthetic process
LEO77_RS18700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LEO77_RS18705	COG0352	thiamine-phosphate diphosphorylase activity
LEO77_RS18710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LEO77_RS18730	COG0745	RESPONSE REGULATOR receiver
LEO77_RS18740	COG0189	ligase activity
LEO77_RS18785	COG1366	Belongs to the anti-sigma-factor antagonist family
LEO77_RS18790	COG2172	sigma factor antagonist activity
LEO77_RS18795	COG2205	protein histidine kinase activity
LEO77_RS18795	COG0784	Response regulator, receiver
LEO77_RS18795	COG5002	protein histidine kinase activity
LEO77_RS18800	COG3437	response regulator, receiver
LEO77_RS18810	COG0477	Major facilitator Superfamily
LEO77_RS18830	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LEO77_RS18835	COG1263	PTS System
LEO77_RS18835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LEO77_RS18840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LEO77_RS18845	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LEO77_RS18855	COG0312	modulator of DNA gyrase
LEO77_RS18860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LEO77_RS18870	COG3164	Protein of unknown function
LEO77_RS18875	COG1530	ribonuclease E activity
LEO77_RS18880	COG0424	maF-like protein
LEO77_RS18885	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LEO77_RS18890	COG1792	Involved in formation and maintenance of cell shape
LEO77_RS18895	COG1077	Cell shape determining protein MreB Mrl
LEO77_RS18940	COG1459	type II secretion system
LEO77_RS18945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LEO77_RS18990	COG2200	EAL domain
LEO77_RS18990	COG2199	diguanylate cyclase activity
LEO77_RS18995	COG2200	EAL domain
LEO77_RS19000	COG0387	Pfam Sodium calcium exchanger
LEO77_RS19005	COG2986	histidine ammonia-lyase
LEO77_RS19010	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LEO77_RS19015	COG0010	Belongs to the arginase family
LEO77_RS19020	COG1228	amidohydrolase
LEO77_RS19025	COG2188	Transcriptional regulator
LEO77_RS19030	COG0288	reversible hydration of carbon dioxide
LEO77_RS19040	COG2177	Part of the ABC transporter FtsEX involved in
LEO77_RS19045	COG2884	Cell division ATP-binding protein ftsE
LEO77_RS19050	COG0552	protein localization to endoplasmic reticulum
LEO77_RS19055	COG0742	ribosomal rna small subunit methyltransferase
LEO77_RS19080	COG2249	NAD(P)H dehydrogenase (quinone) activity
LEO77_RS19085	COG0583	DNA-binding transcription factor activity
LEO77_RS19090	COG4221	oxidoreductase activity
LEO77_RS19105	COG1770	oligopeptidase
LEO77_RS19125	COG0312	modulator of DNA gyrase
LEO77_RS19130	COG3028	Belongs to the UPF0307 family
LEO77_RS19135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LEO77_RS19145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LEO77_RS19155	COG1011	Hydrolase
LEO77_RS19170	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LEO77_RS19175	COG0019	diaminopimelate decarboxylase activity
LEO77_RS19185	COG1965	Belongs to the frataxin family
LEO77_RS19190	COG0400	carboxylic ester hydrolase activity
LEO77_RS19195	COG3072	Adenylate cyclase
LEO77_RS19200	COG0181	hydroxymethylbilane synthase activity
LEO77_RS19210	COG2959	enzyme of heme biosynthesis
LEO77_RS19225	COG1494	fructose-1,6-bisphosphatase
LEO77_RS19280	COG0795	lipopolysaccharide-transporting ATPase activity
LEO77_RS19285	COG0795	lipopolysaccharide-transporting ATPase activity
LEO77_RS19290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LEO77_RS19295	COG2927	DNA polymerase III (CHI subunit)
LEO77_RS19320	COG1247	-acetyltransferase
LEO77_RS19340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LEO77_RS19345	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LEO77_RS19350	COG5380	lipid catabolic process
LEO77_RS19365	COG4533	DNA binding
LEO77_RS19375	COG2873	o-acetylhomoserine
LEO77_RS19405	COG3842	ATPase activity
LEO77_RS19415	COG1175	transmembrane transport
LEO77_RS19455	COG0346	lactoylglutathione lyase activity
LEO77_RS19465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LEO77_RS19470	COG1074	ATP-dependent DNA helicase activity
LEO77_RS19475	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LEO77_RS19480	COG2259	Doxx family
LEO77_RS19485	COG1741	Belongs to the pirin family
LEO77_RS19495	COG0583	DNA-binding transcription factor activity
LEO77_RS19525	COG4771	TonB-dependent receptor
LEO77_RS19565	COG0203	ribosomal protein L17
LEO77_RS19570	COG0202	RNA polymerase activity
LEO77_RS19575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LEO77_RS19580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LEO77_RS19585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LEO77_RS19590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LEO77_RS19595	COG0201	protein transport
LEO77_RS19600	COG0200	Binds to the 23S rRNA
LEO77_RS19605	COG1841	ribosomal large subunit assembly
LEO77_RS19610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LEO77_RS19615	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LEO77_RS19620	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LEO77_RS19625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LEO77_RS19630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LEO77_RS19635	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LEO77_RS19640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LEO77_RS19645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LEO77_RS19650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LEO77_RS19655	COG0255	Belongs to the universal ribosomal protein uL29 family
LEO77_RS19660	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LEO77_RS19665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LEO77_RS19670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LEO77_RS19675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LEO77_RS19680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LEO77_RS19685	COG0089	rRNA binding
LEO77_RS19690	COG0088	Forms part of the polypeptide exit tunnel
LEO77_RS19695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LEO77_RS19700	COG0051	transcription antitermination factor activity, RNA binding
LEO77_RS19720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LEO77_RS19725	COG2183	response to ionizing radiation
LEO77_RS19745	COG0596	Alpha beta hydrolase
LEO77_RS19750	COG1040	competence protein
LEO77_RS19755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LEO77_RS19755	COG0316	Belongs to the HesB IscA family
LEO77_RS19760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LEO77_RS19765	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LEO77_RS19770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO77_RS19775	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LEO77_RS19780	COG4942	peptidase
LEO77_RS19790	COG1609	Transcriptional regulator
LEO77_RS19795	COG0800	Aldolase
LEO77_RS19805	COG3265	gluconokinase activity
LEO77_RS19810	COG2610	gluconate transmembrane transporter activity
LEO77_RS19815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LEO77_RS19820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LEO77_RS19830	COG0456	acetyltransferase
LEO77_RS19835	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LEO77_RS19840	COG1490	D-aminoacyl-tRNA deacylase activity
LEO77_RS19845	COG1295	ribonuclease BN
LEO77_RS19850	COG0281	malic enzyme
LEO77_RS19855	COG0814	amino acid
LEO77_RS19860	COG0702	epimerase
LEO77_RS19870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LEO77_RS19875	COG0254	rRNA binding
LEO77_RS19890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LEO77_RS19895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LEO77_RS19905	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LEO77_RS19915	COG0514	ATP-dependent DNA helicase (RecQ)
LEO77_RS19920	COG2050	protein possibly involved in aromatic compounds catabolism
LEO77_RS19935	COG2258	MOSC domain
LEO77_RS19940	COG1177	transmembrane transport
LEO77_RS19945	COG1176	ABC-type spermidine putrescine transport system, permease component I
LEO77_RS19950	COG3842	ATPase activity
LEO77_RS19970	COG0174	glutamine synthetase
LEO77_RS19990	COG3045	CreA protein
LEO77_RS19995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LEO77_RS20000	COG0443	Heat shock 70 kDa protein
LEO77_RS20015	COG0366	Alpha amylase catalytic
LEO77_RS20030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LEO77_RS20040	COG4211	Belongs to the binding-protein-dependent transport system permease family
LEO77_RS20045	COG1129	ABC transporter
LEO77_RS20055	COG3250	beta-galactosidase activity
LEO77_RS20060	COG1609	Transcriptional regulator
LEO77_RS20065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LEO77_RS20070	COG1085	galactose-1-phosphate uridylyltransferase
LEO77_RS20075	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LEO77_RS20080	COG2017	converts alpha-aldose to the beta-anomer
LEO77_RS20085	COG1609	Transcriptional regulator
LEO77_RS20095	COG2211	Major facilitator Superfamily
LEO77_RS20110	COG1968	undecaprenyl-diphosphatase activity
LEO77_RS20120	COG1595	DNA-templated transcription, initiation
LEO77_RS20145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LEO77_RS20150	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LEO77_RS20165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LEO77_RS20170	COG1131	(ABC) transporter
LEO77_RS20175	COG0842	Transport permease protein
LEO77_RS20180	COG0842	Transport permease protein
LEO77_RS20185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LEO77_RS20195	COG2116	formate transmembrane transporter activity
LEO77_RS20200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LEO77_RS20200	COG1648	precorrin-2 dehydrogenase activity
LEO77_RS20205	COG2239	Acts as a magnesium transporter
LEO77_RS20215	COG0737	Belongs to the 5'-nucleotidase family
LEO77_RS20220	COG1079	Belongs to the binding-protein-dependent transport system permease family
LEO77_RS20225	COG4603	Belongs to the binding-protein-dependent transport system permease family
LEO77_RS20230	COG3845	ABC transporter
LEO77_RS20235	COG1744	ABC transporter substrate-binding protein PnrA-like
LEO77_RS20240	COG0210	DNA helicase
LEO77_RS20300	COG1280	lysine exporter protein (LysE YggA)
LEO77_RS20330	COG3307	-O-antigen
LEO77_RS20340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LEO77_RS20355	COG1063	alcohol dehydrogenase
LEO77_RS20360	COG3245	cytochrome
LEO77_RS20375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LEO77_RS20380	COG2166	iron-sulfur cluster assembly
LEO77_RS20385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LEO77_RS20410	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
LEO77_RS20415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LEO77_RS20420	COG1739	Uncharacterized protein family UPF0029
LEO77_RS20425	COG0006	proline dipeptidase activity
LEO77_RS20430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LEO77_RS20435	COG1024	Enoyl-CoA hydratase
LEO77_RS20435	COG1250	3-hydroxyacyl-CoA dehydrogenase
LEO77_RS20440	COG0183	Belongs to the thiolase family
LEO77_RS20470	COG0425	Belongs to the sulfur carrier protein TusA family
LEO77_RS20475	COG0251	oxidation-reduction process
LEO77_RS20480	COG2885	chlorophyll binding
LEO77_RS20485	COG2818	Glycosylase
LEO77_RS20490	COG0752	glycyl-tRNA synthetase alpha subunit
LEO77_RS20495	COG0751	glycine-tRNA ligase activity
LEO77_RS20505	COG2200	EAL domain
LEO77_RS20505	COG2202	Pas domain
LEO77_RS20505	COG2199	diguanylate cyclase activity
LEO77_RS20510	COG0348	domain, Protein
LEO77_RS20515	COG2188	Transcriptional regulator
LEO77_RS20530	COG1609	Transcriptional regulator
LEO77_RS20560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LEO77_RS20575	COG2960	long-chain fatty acid transporting porin activity
LEO77_RS20580	COG5001	Diguanylate cyclase
LEO77_RS20590	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LEO77_RS20605	COG3118	belongs to the thioredoxin family
LEO77_RS20610	COG0513	Belongs to the DEAD box helicase family
LEO77_RS20615	COG0248	Ppx GppA phosphatase
LEO77_RS20630	COG0742	ribosomal rna small subunit methyltransferase
LEO77_RS20635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LEO77_RS20655	COG3397	chitin binding
LEO77_RS20670	COG0084	hydrolase, TatD family'
LEO77_RS20675	COG0805	protein transport
LEO77_RS20680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO77_RS20685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LEO77_RS20690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LEO77_RS20700	COG2226	methyltransferase
LEO77_RS20705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LEO77_RS20710	COG0402	S-adenosylhomocysteine deaminase activity
LEO77_RS20715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LEO77_RS20750	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LEO77_RS20755	COG0848	biopolymer transport protein
LEO77_RS20760	COG0811	peptide transport
LEO77_RS20765	COG0811	peptide transport
LEO77_RS20775	COG2771	luxR family
LEO77_RS20780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LEO77_RS20785	COG1349	DNA-binding transcription factor activity
LEO77_RS20790	COG0745	RESPONSE REGULATOR receiver
LEO77_RS20795	COG2205	protein histidine kinase activity
LEO77_RS20805	COG4452	Inner membrane protein CreD
LEO77_RS20820	COG0297	glycogen (starch) synthase activity
LEO77_RS20820	COG0438	transferase activity, transferring glycosyl groups
LEO77_RS20865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LEO77_RS20870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LEO77_RS20875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LEO77_RS20880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LEO77_RS20885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LEO77_RS20890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LEO77_RS20895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LEO77_RS20900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LEO77_RS20910	COG0356	it plays a direct role in the translocation of protons across the membrane
LEO77_RS20920	COG1475	DNA binding
LEO77_RS20925	COG1192	Involved in chromosome partitioning
LEO77_RS20930	COG0357	Ribosomal RNA small subunit methyltransferase G
LEO77_RS20935	COG0445	tRNA wobble uridine modification
LEO77_RS20940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LEO77_RS20950	COG4615	Cyclic peptide transporter
LEO77_RS20955	COG1120	ATPase activity
LEO77_RS20960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LEO77_RS20975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LEO77_RS20995	COG3550	peptidyl-serine autophosphorylation
LEO77_RS21045	COG1695	Transcriptional regulator
LEO77_RS21070	COG3173	Aminoglycoside phosphotransferase
LEO77_RS21160	COG4974	Belongs to the 'phage' integrase family
LEO77_RS21165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LEO77_RS21170	COG0706	membrane insertase activity
LEO77_RS21175	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LEO77_RS21180	COG0594	ribonuclease P activity
LEO77_RS21185	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LEO77_RS21195	COG1126	abc transporter atp-binding protein
LEO77_RS21210	COG3093	addiction module antidote protein HigA
LEO77_RS21300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LEO77_RS21340	COG0697	spore germination
LEO77_RS21385	COG1192	Involved in chromosome partitioning
LEO77_RS21440	COG2154	pterin-4-alpha-carbinolamine dehydratase