locus-tag	class	description
GIS01_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GIS01_RS00010	COG0592	DNA-directed DNA polymerase activity
GIS01_RS00020	COG0187	DNA topoisomerase II activity
GIS01_RS00030	COG2378	regulation of single-species biofilm formation
GIS01_RS00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GIS01_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
GIS01_RS00050	COG0071	Belongs to the small heat shock protein (HSP20) family
GIS01_RS00055	COG3177	Filamentation induced by cAMP protein fic
GIS01_RS00065	COG3977	Valine--pyruvate aminotransferase
GIS01_RS00080	COG2814	Major facilitator Superfamily
GIS01_RS00085	COG0745	RESPONSE REGULATOR receiver
GIS01_RS00090	COG2205	protein histidine kinase activity
GIS01_RS00115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GIS01_RS00120	COG4191	Histidine kinase
GIS01_RS00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_RS00125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_RS00130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_RS00135	COG1309	transcriptional regulator
GIS01_RS00165	COG0561	phosphatase activity
GIS01_RS00170	COG2267	carboxylic ester hydrolase activity
GIS01_RS00180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GIS01_RS00185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GIS01_RS00190	COG1758	RNA polymerase activity
GIS01_RS00195	COG0194	GDP metabolic process
GIS01_RS00205	COG0859	PFAM glycosyl transferase family 9
GIS01_RS00210	COG3642	lipopolysaccharide core region biosynthetic process
GIS01_RS00250	COG0589	response to stress
GIS01_RS00255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GIS01_RS00260	COG1528	Iron-storage protein
GIS01_RS00265	COG2081	HI0933 family
GIS01_RS00270	COG3275	phosphorelay sensor kinase activity
GIS01_RS00275	COG3279	Response regulator of the LytR AlgR family
GIS01_RS00280	COG2223	nitrite transmembrane transporter activity
GIS01_RS00285	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GIS01_RS00290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GIS01_RS00305	COG0583	DNA-binding transcription factor activity
GIS01_RS00315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GIS01_RS00345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GIS01_RS00350	COG2166	iron-sulfur cluster assembly
GIS01_RS00355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GIS01_RS00370	COG3245	cytochrome
GIS01_RS00375	COG1063	alcohol dehydrogenase
GIS01_RS00390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GIS01_RS00400	COG3307	-O-antigen
GIS01_RS00435	COG1280	lysine exporter protein (LysE YggA)
GIS01_RS00470	COG1943	Transposase
GIS01_RS00480	COG2856	Zn peptidase
GIS01_RS00495	COG0210	DNA helicase
GIS01_RS00530	COG2239	Acts as a magnesium transporter
GIS01_RS00535	COG1648	precorrin-2 dehydrogenase activity
GIS01_RS00535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GIS01_RS00540	COG2116	formate transmembrane transporter activity
GIS01_RS00545	COG2146	nitrite reductase [NAD(P)H] activity
GIS01_RS00550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GIS01_RS00555	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GIS01_RS00560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GIS01_RS00570	COG0018	arginyl-trna synthetase
GIS01_RS00580	COG1595	DNA-templated transcription, initiation
GIS01_RS00590	COG1968	undecaprenyl-diphosphatase activity
GIS01_RS00595	COG2017	converts alpha-aldose to the beta-anomer
GIS01_RS00600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GIS01_RS00605	COG1085	galactose-1-phosphate uridylyltransferase
GIS01_RS00610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GIS01_RS00615	COG1609	Transcriptional regulator
GIS01_RS00620	COG3250	beta-galactosidase activity
GIS01_RS00630	COG1129	ABC transporter
GIS01_RS00635	COG4211	Belongs to the binding-protein-dependent transport system permease family
GIS01_RS00645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GIS01_RS00660	COG0366	Alpha amylase catalytic
GIS01_RS00675	COG0443	Heat shock 70 kDa protein
GIS01_RS00680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GIS01_RS00685	COG3045	CreA protein
GIS01_RS00700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GIS01_RS00705	COG0174	glutamine synthetase
GIS01_RS00725	COG3842	ATPase activity
GIS01_RS00730	COG1176	ABC-type spermidine putrescine transport system, permease component I
GIS01_RS00735	COG1177	transmembrane transport
GIS01_RS00740	COG2258	MOSC domain
GIS01_RS00755	COG2050	protein possibly involved in aromatic compounds catabolism
GIS01_RS00760	COG0514	ATP-dependent DNA helicase (RecQ)
GIS01_RS00770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GIS01_RS00780	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GIS01_RS00785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GIS01_RS00800	COG0254	rRNA binding
GIS01_RS00805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GIS01_RS00815	COG0702	epimerase
GIS01_RS00820	COG0814	amino acid
GIS01_RS00825	COG0281	malic enzyme
GIS01_RS00830	COG1295	ribonuclease BN
GIS01_RS00835	COG1490	D-aminoacyl-tRNA deacylase activity
GIS01_RS00840	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GIS01_RS00845	COG0456	acetyltransferase
GIS01_RS00855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GIS01_RS00860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GIS01_RS00865	COG2610	gluconate transmembrane transporter activity
GIS01_RS00870	COG3265	gluconokinase activity
GIS01_RS00875	COG0129	dihydroxy-acid dehydratase activity
GIS01_RS00880	COG0800	Aldolase
GIS01_RS00895	COG1609	Transcriptional regulator
GIS01_RS00905	COG4942	peptidase
GIS01_RS00910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GIS01_RS00915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GIS01_RS00920	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GIS01_RS00925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GIS01_RS00930	COG0316	Belongs to the HesB IscA family
GIS01_RS00930	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GIS01_RS00935	COG1040	competence protein
GIS01_RS00940	COG0596	Alpha beta hydrolase
GIS01_RS00960	COG2183	response to ionizing radiation
GIS01_RS00965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GIS01_RS00970	COG0745	RESPONSE REGULATOR receiver
GIS01_RS00985	COG0051	transcription antitermination factor activity, RNA binding
GIS01_RS00990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GIS01_RS00995	COG0088	Forms part of the polypeptide exit tunnel
GIS01_RS01000	COG0089	rRNA binding
GIS01_RS01005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GIS01_RS01010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GIS01_RS01015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GIS01_RS01020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GIS01_RS01025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GIS01_RS01030	COG0255	Belongs to the universal ribosomal protein uL29 family
GIS01_RS01035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GIS01_RS01040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GIS01_RS01045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GIS01_RS01050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GIS01_RS01055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GIS01_RS01060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GIS01_RS01065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GIS01_RS01070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GIS01_RS01075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GIS01_RS01080	COG1841	ribosomal large subunit assembly
GIS01_RS01085	COG0200	Binds to the 23S rRNA
GIS01_RS01090	COG0201	protein transport
GIS01_RS01095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GIS01_RS01100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GIS01_RS01105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GIS01_RS01110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GIS01_RS01115	COG0202	RNA polymerase activity
GIS01_RS01120	COG0203	ribosomal protein L17
GIS01_RS01155	COG4771	TonB-dependent receptor
GIS01_RS01160	COG3706	GGDEF domain
GIS01_RS01170	COG0745	RESPONSE REGULATOR receiver
GIS01_RS01190	COG0583	DNA-binding transcription factor activity
GIS01_RS01200	COG1741	Belongs to the pirin family
GIS01_RS01205	COG2259	Doxx family
GIS01_RS01210	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GIS01_RS01215	COG1074	ATP-dependent DNA helicase activity
GIS01_RS01220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GIS01_RS01230	COG3706	GGDEF domain
GIS01_RS01260	COG1175	transmembrane transport
GIS01_RS01270	COG3842	ATPase activity
GIS01_RS01300	COG2873	o-acetylhomoserine
GIS01_RS01310	COG4533	DNA binding
GIS01_RS01315	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GIS01_RS01330	COG5380	lipid catabolic process
GIS01_RS01335	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GIS01_RS01340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GIS01_RS01365	COG0753	catalase activity
GIS01_RS01370	COG0454	-acetyltransferase
GIS01_RS01370	COG0456	acetyltransferase
GIS01_RS01395	COG2927	DNA polymerase III (CHI subunit)
GIS01_RS01400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GIS01_RS01405	COG0795	lipopolysaccharide-transporting ATPase activity
GIS01_RS01410	COG0795	lipopolysaccharide-transporting ATPase activity
GIS01_RS01445	COG0531	amino acid
GIS01_RS01465	COG1494	fructose-1,6-bisphosphatase
GIS01_RS01480	COG2959	enzyme of heme biosynthesis
GIS01_RS01490	COG0181	hydroxymethylbilane synthase activity
GIS01_RS01495	COG3072	Adenylate cyclase
GIS01_RS01500	COG0400	carboxylic ester hydrolase activity
GIS01_RS01505	COG1965	Belongs to the frataxin family
GIS01_RS01515	COG0019	diaminopimelate decarboxylase activity
GIS01_RS01520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GIS01_RS01535	COG1011	Hydrolase
GIS01_RS01555	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GIS01_RS01560	COG3028	Belongs to the UPF0307 family
GIS01_RS01585	COG0328	RNA-DNA hybrid ribonuclease activity
GIS01_RS01630	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GIS01_RS01660	COG0312	modulator of DNA gyrase
GIS01_RS01665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GIS01_RS01670	COG5007	Belongs to the BolA IbaG family
GIS01_RS01680	COG2854	intermembrane phospholipid transfer
GIS01_RS01685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GIS01_RS01690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GIS01_RS01695	COG1127	ABC transporter
GIS01_RS01700	COG0517	IMP dehydrogenase activity
GIS01_RS01700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GIS01_RS01705	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GIS01_RS01710	COG3117	lipopolysaccharide transmembrane transporter activity
GIS01_RS01715	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GIS01_RS01720	COG1137	ATPase activity
GIS01_RS01735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_RS01740	COG1660	Displays ATPase and GTPase activities
GIS01_RS01745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_RS01750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_RS01750	COG3711	transcriptional antiterminator
GIS01_RS01765	COG3964	amidohydrolase
GIS01_RS01795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GIS01_RS01800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GIS01_RS01810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GIS01_RS01815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GIS01_RS01820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GIS01_RS01825	COG0723	plastoquinol--plastocyanin reductase activity
GIS01_RS01830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GIS01_RS01835	COG2857	Cytochrome c1
GIS01_RS01840	COG0625	glutathione transferase activity
GIS01_RS01845	COG2969	positive regulation of protein catabolic process
GIS01_RS01850	COG2823	Periplasmic or secreted lipoprotein
GIS01_RS01855	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GIS01_RS01860	COG0792	nuclease activity
GIS01_RS01865	COG3107	peptidoglycan biosynthetic process
GIS01_RS01870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GIS01_RS01895	COG1987	bacterial-type flagellum assembly
GIS01_RS01915	COG2204	response regulator
GIS01_RS01920	COG1677	Flagellar hook-basal body complex protein FliE
GIS01_RS01930	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GIS01_RS01965	COG1815	bacterial-type flagellum-dependent cell motility
GIS01_RS01970	COG1558	bacterial-type flagellum-dependent cell motility
GIS01_RS01975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GIS01_RS01980	COG1749	Flagellar hook protein flgE
GIS01_RS01985	COG4787	bacterial-type flagellum-dependent cell motility
GIS01_RS01990	COG4786	Flagellar basal body rod
GIS01_RS01995	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GIS01_RS02000	COG1706	bacterial-type flagellum-dependent cell motility
GIS01_RS02015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_RS02025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_RS02030	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GIS01_RS02055	COG1191	sigma factor activity
GIS01_RS02060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GIS01_RS02075	COG1388	LysM domain
GIS01_RS02075	COG0741	lytic transglycosylase activity
GIS01_RS02080	COG2001	Belongs to the MraZ family
GIS01_RS02085	COG0275	rRNA processing
GIS01_RS02090	COG3116	cell division
GIS01_RS02095	COG0768	penicillin binding
GIS01_RS02105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GIS01_RS02110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GIS01_RS02115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GIS01_RS02120	COG0772	Belongs to the SEDS family
GIS01_RS02125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GIS01_RS02130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GIS01_RS02140	COG0849	cell division
GIS01_RS02145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GIS01_RS02150	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GIS01_RS02160	COG0653	protein targeting
GIS01_RS02165	COG0494	nUDIX hydrolase
GIS01_RS02170	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GIS01_RS02175	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GIS01_RS02185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GIS01_RS02190	COG1459	type II secretion system
GIS01_RS02195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GIS01_RS02220	COG2186	Transcriptional regulator
GIS01_RS02225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GIS01_RS02230	COG0508	dehydrogenase complex catalyzes the overall conversion of
GIS01_RS02235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GIS01_RS02245	COG0840	transmembrane signaling receptor activity
GIS01_RS02250	COG1752	Esterase of the alpha-beta hydrolase superfamily
GIS01_RS02255	COG1049	propionate catabolic process, 2-methylcitrate cycle
GIS01_RS02260	COG2200	EAL domain
GIS01_RS02270	COG0523	cobalamin synthesis protein
GIS01_RS02275	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_RS02290	COG0477	Major facilitator Superfamily
GIS01_RS02305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GIS01_RS02310	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GIS01_RS02340	COG3422	double-strand break repair
GIS01_RS02385	COG2314	TM2 domain
GIS01_RS02435	COG0165	Argininosuccinate lyase
GIS01_RS02440	COG0137	argininosuccinate synthase activity
GIS01_RS02450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GIS01_RS02455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GIS01_RS02465	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GIS01_RS02475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GIS01_RS02485	COG0583	DNA-binding transcription factor activity
GIS01_RS02490	COG1380	Effector of murein hydrolase LrgA
GIS01_RS02495	COG1346	cytolysis
GIS01_RS02505	COG4667	esterase of the alpha-beta hydrolase superfamily
GIS01_RS02510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GIS01_RS02515	COG1546	Belongs to the CinA family
GIS01_RS02520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GIS01_RS02530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GIS01_RS02535	COG0527	aspartate kinase activity
GIS01_RS02540	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GIS01_RS02575	COG1686	Belongs to the peptidase S11 family
GIS01_RS02580	COG0586	Pfam SNARE associated Golgi protein
GIS01_RS02585	COG1253	flavin adenine dinucleotide binding
GIS01_RS02590	COG0252	asparaginase activity
GIS01_RS02610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GIS01_RS02610	COG1263	PTS System
GIS01_RS02615	COG0366	Alpha amylase catalytic
GIS01_RS02620	COG0110	maltose O-acetyltransferase activity
GIS01_RS02635	COG0564	pseudouridine synthase activity
GIS01_RS02640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GIS01_RS02670	COG2926	Belongs to the UPF0265 family
GIS01_RS02680	COG0561	phosphatase activity
GIS01_RS02690	COG1058	Belongs to the CinA family
GIS01_RS02690	COG1546	Belongs to the CinA family
GIS01_RS02700	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GIS01_RS02710	COG1522	sequence-specific DNA binding
GIS01_RS02715	COG1368	sulfuric ester hydrolase activity
GIS01_RS02750	COG4221	oxidoreductase activity
GIS01_RS02765	COG1979	alcohol dehydrogenase
GIS01_RS02770	COG1803	Methylglyoxal synthase
GIS01_RS02795	COG1444	tRNA N-acetyltransferase activity
GIS01_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_RS02805	COG0784	Response regulator, receiver
GIS01_RS02805	COG0835	chemotaxis
GIS01_RS02815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GIS01_RS02820	COG2949	membrane
GIS01_RS02825	COG3291	Pkd domain containing protein
GIS01_RS02835	COG3539	Fimbrial protein
GIS01_RS02845	COG3188	usher protein
GIS01_RS02850	COG3121	Chaperone
GIS01_RS02855	COG3539	Fimbrial protein
GIS01_RS02870	COG0318	PFAM AMP-dependent synthetase and ligase
GIS01_RS02875	COG1441	menaquinone biosynthetic process
GIS01_RS02880	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GIS01_RS02885	COG0596	Alpha beta hydrolase
GIS01_RS02890	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GIS01_RS02895	COG1169	isochorismate synthase
GIS01_RS02900	COG1575	Belongs to the MenA family. Type 1 subfamily
GIS01_RS02925	COG0513	Belongs to the DEAD box helicase family
GIS01_RS02930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GIS01_RS02935	COG1988	membrane-bound metal-dependent
GIS01_RS02940	COG1671	Belongs to the UPF0178 family
GIS01_RS02960	COG0484	heat shock protein binding
GIS01_RS02970	COG3722	fumarate hydratase activity
GIS01_RS02975	COG0246	Mannitol dehydrogenase
GIS01_RS02980	COG2213	PTS system mannitol-specific
GIS01_RS02980	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_RS02985	COG1560	Kdo2-lipid A biosynthetic process
GIS01_RS02990	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GIS01_RS02990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GIS01_RS02995	COG1538	Outer membrane efflux protein
GIS01_RS03000	COG0494	nUDIX hydrolase
GIS01_RS03005	COG3151	Protein conserved in bacteria
GIS01_RS03015	COG3150	esterase
GIS01_RS03020	COG0187	DNA topoisomerase II activity
GIS01_RS03030	COG3104	oligopeptide transport
GIS01_RS03060	COG2084	Dehydrogenase
GIS01_RS03065	COG0583	DNA-binding transcription factor activity
GIS01_RS03070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GIS01_RS03090	COG0204	Acyl-transferase
GIS01_RS03095	COG1842	Phage shock protein A
GIS01_RS03110	COG2827	Endonuclease containing a URI domain
GIS01_RS03125	COG1573	uracil-dna glycosylase
GIS01_RS03130	COG0697	spore germination
GIS01_RS03135	COG0583	DNA-binding transcription factor activity
GIS01_RS03140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GIS01_RS03145	COG1121	(ABC) transporter
GIS01_RS03150	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GIS01_RS03170	COG0739	heme binding
GIS01_RS03180	COG3068	Protein conserved in bacteria
GIS01_RS03200	COG0617	tRNA 3'-terminal CCA addition
GIS01_RS03205	COG1194	a g-specific adenine glycosylase
GIS01_RS03210	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GIS01_RS03220	COG3111	PFAM Bacterial OB fold (BOF) protein
GIS01_RS03225	COG3240	lipase activity
GIS01_RS03235	COG3706	GGDEF domain
GIS01_RS03240	COG0557	exoribonuclease II activity
GIS01_RS03260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GIS01_RS03270	COG2153	protein acetylation
GIS01_RS03275	COG0513	Belongs to the DEAD box helicase family
GIS01_RS03280	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GIS01_RS03305	COG0735	belongs to the Fur family
GIS01_RS03370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GIS01_RS03375	COG3385	transposase activity
GIS01_RS03380	COG1022	Amp-dependent synthetase and ligase
GIS01_RS03390	COG0456	acetyltransferase
GIS01_RS03405	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GIS01_RS03410	COG0745	RESPONSE REGULATOR receiver
GIS01_RS03410	COG3706	GGDEF domain
GIS01_RS03415	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_RS03430	COG0477	Major facilitator Superfamily
GIS01_RS03435	COG0583	DNA-binding transcription factor activity
GIS01_RS03445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GIS01_RS03450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GIS01_RS03460	COG0673	inositol 2-dehydrogenase activity
GIS01_RS03470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GIS01_RS03475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GIS01_RS03480	COG3036	rescue of stalled ribosome
GIS01_RS03490	COG0138	bifunctional purine biosynthesis protein purh
GIS01_RS03495	COG0151	Belongs to the GarS family
GIS01_RS03515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GIS01_RS03520	COG0358	DNA primase activity
GIS01_RS03525	COG1610	YqeY-like protein
GIS01_RS03530	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GIS01_RS03535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GIS01_RS03540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GIS01_RS03545	COG1027	Aspartate ammonia-lyase
GIS01_RS03550	COG3030	protein affecting phage T7 exclusion by the F plasmid
GIS01_RS03560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GIS01_RS03565	COG0459	protein refolding
GIS01_RS03615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GIS01_RS03620	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GIS01_RS03625	COG1178	ABC-type Fe3 transport system permease component
GIS01_RS03630	COG4143	(ABC) transporter
GIS01_RS03645	COG0066	3-isopropylmalate dehydratase activity
GIS01_RS03650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GIS01_RS03655	COG0473	3-isopropylmalate dehydrogenase activity
GIS01_RS03660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GIS01_RS03685	COG0028	Belongs to the TPP enzyme family
GIS01_RS03690	COG0440	acetolactate synthase activity
GIS01_RS03705	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GIS01_RS03720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_RS03750	COG0745	RESPONSE REGULATOR receiver
GIS01_RS03755	COG3104	oligopeptide transport
GIS01_RS03760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GIS01_RS03765	COG1555	photosystem II stabilization
GIS01_RS03770	COG0280	phosphate acetyltransferase
GIS01_RS03770	COG0857	belongs to the CobB CobQ family
GIS01_RS03775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GIS01_RS03780	COG3092	negative regulation of chromosome organization
GIS01_RS03785	COG3013	Belongs to the UPF0304 family
GIS01_RS03790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GIS01_RS03795	COG2716	regulation of RNA biosynthetic process
GIS01_RS03800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GIS01_RS03805	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GIS01_RS03810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GIS01_RS03845	COG5002	protein histidine kinase activity
GIS01_RS03845	COG2198	Histidine kinase
GIS01_RS03845	COG0784	Response regulator, receiver
GIS01_RS03870	COG0840	transmembrane signaling receptor activity
GIS01_RS03880	COG1464	Belongs to the NlpA lipoprotein family
GIS01_RS03885	COG2011	ABC-type metal ion transport system permease component
GIS01_RS03890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GIS01_RS03910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GIS01_RS03910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GIS01_RS03915	COG0802	atpase or kinase
GIS01_RS03925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GIS01_RS03930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GIS01_RS03935	COG1923	regulation of RNA biosynthetic process
GIS01_RS03940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GIS01_RS03945	COG0330	HflC and HflK could
GIS01_RS03950	COG0330	HflC and HflK could
GIS01_RS03955	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GIS01_RS03960	COG0142	geranyltranstransferase activity
GIS01_RS03965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GIS01_RS03970	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GIS01_RS03975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GIS01_RS03990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GIS01_RS04010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GIS01_RS04020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GIS01_RS04025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GIS01_RS04030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GIS01_RS04035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GIS01_RS04040	COG3178	'Phosphotransferase
GIS01_RS04045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GIS01_RS04050	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GIS01_RS04055	COG2195	Cleaves the N-terminal amino acid of tripeptides
GIS01_RS04065	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GIS01_RS04085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GIS01_RS04100	COG4628	conserved protein (DUF2132)
GIS01_RS04105	COG0688	phosphatidylethanolamine metabolic process
GIS01_RS04115	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GIS01_RS04145	COG1278	Cold shock
GIS01_RS04155	COG0840	transmembrane signaling receptor activity
GIS01_RS04160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GIS01_RS04165	COG2252	PERMEase
GIS01_RS04175	COG0488	(ABC) transporter
GIS01_RS04190	COG0741	lytic transglycosylase activity
GIS01_RS04200	COG3416	Protein conserved in bacteria
GIS01_RS04220	COG4608	Belongs to the ABC transporter superfamily
GIS01_RS04225	COG0444	Belongs to the ABC transporter superfamily
GIS01_RS04235	COG4239	(ABC) transporter, permease
GIS01_RS04240	COG4174	ABC transporter (Permease)
GIS01_RS04245	COG4206	TonB-dependent receptor
GIS01_RS04255	COG0811	peptide transport
GIS01_RS04260	COG0811	peptide transport
GIS01_RS04265	COG0848	biopolymer transport protein
GIS01_RS04285	COG0616	signal peptide processing
GIS01_RS04290	COG0446	pyridine nucleotide-disulphide oxidoreductase
GIS01_RS04290	COG1902	pentaerythritol trinitrate reductase activity
GIS01_RS04295	COG0778	Nitroreductase
GIS01_RS04300	COG0110	maltose O-acetyltransferase activity
GIS01_RS04310	COG2264	protein methyltransferase activity
GIS01_RS04315	COG0604	alcohol dehydrogenase
GIS01_RS04320	COG0583	DNA-binding transcription factor activity
GIS01_RS04325	COG1263	PTS System
GIS01_RS04325	COG2190	(PTS) system
GIS01_RS04325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GIS01_RS04330	COG4145	pantothenate transmembrane transporter activity
GIS01_RS04340	COG0439	Biotin carboxylase
GIS01_RS04345	COG0511	ligase activity, forming carbon-carbon bonds
GIS01_RS04350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GIS01_RS04355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GIS01_RS04375	COG3381	protein complex oligomerization
GIS01_RS04385	COG3005	denitrification pathway
GIS01_RS04390	COG0745	RESPONSE REGULATOR receiver
GIS01_RS04400	COG1879	ABC-type sugar transport system periplasmic component
GIS01_RS04405	COG2205	protein histidine kinase activity
GIS01_RS04405	COG2198	Histidine kinase
GIS01_RS04405	COG0784	Response regulator, receiver
GIS01_RS04415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GIS01_RS04420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GIS01_RS04425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GIS01_RS04425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GIS01_RS04440	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GIS01_RS04445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GIS01_RS04450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GIS01_RS04455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GIS01_RS04480	COG2900	Belongs to the SlyX family
GIS01_RS04490	COG0545	Peptidyl-prolyl cis-trans isomerase
GIS01_RS04495	COG2204	response regulator
GIS01_RS04515	COG0737	Belongs to the 5'-nucleotidase family
GIS01_RS04520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GIS01_RS04525	COG0142	geranyltranstransferase activity
GIS01_RS04530	COG1722	exodeoxyribonuclease VII activity
GIS01_RS04535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GIS01_RS04540	COG1360	Flagellar Motor Protein
GIS01_RS04545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GIS01_RS04555	COG1534	Rna-binding protein
GIS01_RS04560	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GIS01_RS04565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GIS01_RS04570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GIS01_RS04575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GIS01_RS04580	COG0149	triose-phosphate isomerase activity
GIS01_RS04585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GIS01_RS04600	COG0779	Required for maturation of 30S ribosomal subunits
GIS01_RS04605	COG0195	Participates in both transcription termination and antitermination
GIS01_RS04610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GIS01_RS04615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GIS01_RS04620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GIS01_RS04625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GIS01_RS04630	COG1185	polyribonucleotide nucleotidyltransferase activity
GIS01_RS04635	COG2201	protein-glutamate methylesterase activity
GIS01_RS04640	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GIS01_RS04650	COG0840	transmembrane signaling receptor activity
GIS01_RS04655	COG0835	chemotaxis
GIS01_RS04665	COG0643	Histidine kinase
GIS01_RS04665	COG2198	Histidine kinase
GIS01_RS04695	COG1280	lysine exporter protein (LysE YggA)
GIS01_RS04700	COG0826	peptidase U32
GIS01_RS04705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GIS01_RS04745	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GIS01_RS04770	COG0300	oxidoreductase activity
GIS01_RS04780	COG0840	transmembrane signaling receptor activity
GIS01_RS04825	COG2226	methyltransferase
GIS01_RS04865	COG1116	anion transmembrane transporter activity
GIS01_RS04885	COG4771	TonB-dependent receptor
GIS01_RS04910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GIS01_RS04915	COG0514	ATP-dependent DNA helicase (RecQ)
GIS01_RS04950	COG0720	synthase
GIS01_RS04975	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GIS01_RS04980	COG0602	queuosine metabolic process
GIS01_RS04990	COG2003	Belongs to the UPF0758 family
GIS01_RS05035	COG5377	YqaJ viral recombinase family
GIS01_RS05065	COG1605	Chorismate mutase
GIS01_RS05065	COG0077	Prephenate dehydratase
GIS01_RS05095	COG3272	Protein of unknown function (DUF1722)
GIS01_RS05100	COG0789	Transcriptional regulator
GIS01_RS05105	COG0415	Belongs to the DNA photolyase family
GIS01_RS05115	COG0300	oxidoreductase activity
GIS01_RS05130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GIS01_RS05160	COG1477	protein flavinylation
GIS01_RS05165	COG2871	sodium ion transport
GIS01_RS05170	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GIS01_RS05175	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GIS01_RS05185	COG1805	sodium ion transport
GIS01_RS05190	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GIS01_RS05195	COG0271	Belongs to the BolA IbaG family
GIS01_RS05200	COG2813	Specifically methylates the guanine in position
GIS01_RS05210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GIS01_RS05215	COG2211	Major facilitator Superfamily
GIS01_RS05220	COG3248	Nucleoside-binding outer membrane protein
GIS01_RS05225	COG1666	GTP binding
GIS01_RS05230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GIS01_RS05245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GIS01_RS05250	COG0840	transmembrane signaling receptor activity
GIS01_RS05255	COG0583	DNA-binding transcription factor activity
GIS01_RS05265	COG2363	Small membrane protein
GIS01_RS05270	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GIS01_RS05280	COG0473	3-isopropylmalate dehydrogenase activity
GIS01_RS05285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GIS01_RS05290	COG1611	Belongs to the LOG family
GIS01_RS05295	COG3706	GGDEF domain
GIS01_RS05305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GIS01_RS05305	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GIS01_RS05315	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GIS01_RS05340	COG0328	RNA-DNA hybrid ribonuclease activity
GIS01_RS05365	COG3645	SOS response
GIS01_RS05365	COG3646	Phage regulatory protein
GIS01_RS05390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GIS01_RS05420	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GIS01_RS05445	COG3098	single-species biofilm formation
GIS01_RS05450	COG0564	pseudouridine synthase activity
GIS01_RS05460	COG4580	involved in the transport of maltose and maltodextrins
GIS01_RS05470	COG1263	PTS System
GIS01_RS05470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GIS01_RS05480	COG2171	N-acyltransferase activity
GIS01_RS05485	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GIS01_RS05490	COG0024	Methionine aminopeptidase
GIS01_RS05495	COG0052	Belongs to the universal ribosomal protein uS2 family
GIS01_RS05500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GIS01_RS05505	COG0528	UMP kinase activity
GIS01_RS05510	COG0233	cytoplasmic translational termination
GIS01_RS05520	COG0575	Belongs to the CDS family
GIS01_RS05525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GIS01_RS05530	COG0750	zinc metalloprotease
GIS01_RS05545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GIS01_RS05550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GIS01_RS05555	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GIS01_RS05560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GIS01_RS05565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GIS01_RS05575	COG0825	malonyl-CoA metabolic process
GIS01_RS05585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GIS01_RS05590	COG1115	amino acid carrier protein
GIS01_RS05605	COG0714	Associated with various cellular activities
GIS01_RS05620	COG0583	DNA-binding transcription factor activity
GIS01_RS05625	COG3104	oligopeptide transport
GIS01_RS05630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GIS01_RS05635	COG1678	Uncharacterized ACR, COG1678
GIS01_RS05640	COG0189	ligase activity
GIS01_RS05645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GIS01_RS05655	COG3091	SprT-like family
GIS01_RS05665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GIS01_RS05680	COG0583	DNA-binding transcription factor activity
GIS01_RS05695	COG0251	oxidation-reduction process
GIS01_RS05710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GIS01_RS05715	COG0739	heme binding
GIS01_RS05720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GIS01_RS05750	COG0814	amino acid
GIS01_RS05770	COG0531	amino acid
GIS01_RS05775	COG3710	Transcriptional regulator
GIS01_RS05780	COG0531	amino acid
GIS01_RS05785	COG1982	Orn Lys Arg decarboxylase major
GIS01_RS05790	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GIS01_RS05800	COG3590	peptidase
GIS01_RS05810	COG2203	Gaf domain
GIS01_RS05810	COG2199	diguanylate cyclase activity
GIS01_RS05845	COG0366	Alpha amylase catalytic
GIS01_RS05860	COG0463	Glycosyl transferase, family 2
GIS01_RS05875	COG2989	Protein conserved in bacteria
GIS01_RS05880	COG3108	Peptidase M15
GIS01_RS05890	COG2860	membrane
GIS01_RS05900	COG1196	nuclear chromosome segregation
GIS01_RS05905	COG3115	cell septum assembly
GIS01_RS05910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GIS01_RS05920	COG1328	CTP reductase activity
GIS01_RS05925	COG0602	queuosine metabolic process
GIS01_RS05955	COG1566	PFAM secretion protein HlyD family protein
GIS01_RS05960	COG1846	Transcriptional regulator
GIS01_RS05970	COG0281	malic enzyme
GIS01_RS05975	COG3290	protein histidine kinase activity
GIS01_RS05985	COG0697	spore germination
GIS01_RS05995	COG3706	GGDEF domain
GIS01_RS06000	COG0346	lactoylglutathione lyase activity
GIS01_RS06005	COG0745	RESPONSE REGULATOR receiver
GIS01_RS06010	COG5002	protein histidine kinase activity
GIS01_RS06020	COG4783	chaperone-mediated protein folding
GIS01_RS06035	COG3142	Participates in the control of copper homeostasis
GIS01_RS06040	COG0545	Peptidyl-prolyl cis-trans isomerase
GIS01_RS06055	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GIS01_RS06065	COG0678	peroxiredoxin activity
GIS01_RS06075	COG0019	diaminopimelate decarboxylase activity
GIS01_RS06080	COG1115	amino acid carrier protein
GIS01_RS06085	COG0095	Lipoate-protein ligase
GIS01_RS06090	COG2233	PERMEase
GIS01_RS06095	COG3706	GGDEF domain
GIS01_RS06105	COG0534	Mate efflux family protein
GIS01_RS06115	COG0281	malic enzyme
GIS01_RS06145	COG0531	amino acid
GIS01_RS06150	COG1752	Esterase of the alpha-beta hydrolase superfamily
GIS01_RS06155	COG3706	GGDEF domain
GIS01_RS06160	COG1566	PFAM secretion protein HlyD family protein
GIS01_RS06170	COG1032	radical SAM domain protein
GIS01_RS06215	COG0583	DNA-binding transcription factor activity
GIS01_RS06220	COG0673	inositol 2-dehydrogenase activity
GIS01_RS06225	COG2920	part of a sulfur-relay system
GIS01_RS06230	COG1289	transmembrane transporter activity
GIS01_RS06235	COG0670	Belongs to the BI1 family
GIS01_RS06250	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GIS01_RS06260	COG3156	type II secretion system protein K
GIS01_RS06265	COG4795	General secretion pathway protein
GIS01_RS06270	COG2165	general secretion pathway protein
GIS01_RS06280	COG2165	general secretion pathway protein
GIS01_RS06285	COG1459	type II secretion system
GIS01_RS06290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GIS01_RS06300	COG3031	protein transport across the cell outer membrane
GIS01_RS06310	COG3267	Type II secretory pathway component ExeA
GIS01_RS06310	COG3409	Peptidoglycan-binding domain 1 protein
GIS01_RS06315	COG2770	Histidine kinase
GIS01_RS06315	COG3437	response regulator, receiver
GIS01_RS06330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GIS01_RS06335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GIS01_RS06340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_RS06350	COG2190	(PTS) system
GIS01_RS06355	COG3706	GGDEF domain
GIS01_RS06360	COG3590	peptidase
GIS01_RS06370	COG1196	nuclear chromosome segregation
GIS01_RS06370	COG3264	Mechanosensitive ion channel
GIS01_RS06375	COG0469	pyruvate kinase activity
GIS01_RS06385	COG3384	dioxygenase
GIS01_RS06390	COG0419	ATPase involved in DNA repair
GIS01_RS06395	COG0420	3'-5' exonuclease activity
GIS01_RS06405	COG2974	May be involved in recombination
GIS01_RS06410	COG0405	Gamma-glutamyltransferase
GIS01_RS06420	COG1283	sodium-dependent phosphate transmembrane transporter activity
GIS01_RS06430	COG0531	amino acid
GIS01_RS06440	COG0531	amino acid
GIS01_RS06455	COG1917	Cupin 2, conserved barrel domain protein
GIS01_RS06455	COG1396	sequence-specific DNA binding
GIS01_RS06460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_RS06480	COG0745	RESPONSE REGULATOR receiver
GIS01_RS06490	COG3038	cytochrome b561
GIS01_RS06495	COG1720	tRNA m6t6A37 methyltransferase activity
GIS01_RS06515	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GIS01_RS06520	COG4988	ABC transporter
GIS01_RS06535	COG0745	RESPONSE REGULATOR receiver
GIS01_RS06545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GIS01_RS06575	COG0798	PFAM Bile acid sodium symporter
GIS01_RS06585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GIS01_RS06605	COG1988	membrane-bound metal-dependent
GIS01_RS06620	COG0159	tryptophan synthase activity
GIS01_RS06625	COG0133	tryptophan synthase activity
GIS01_RS06630	COG0134	indole-3-glycerol-phosphate synthase activity
GIS01_RS06630	COG0135	phosphoribosylanthranilate isomerase activity
GIS01_RS06635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GIS01_RS06640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GIS01_RS06640	COG0512	Glutamine amidotransferase of anthranilate synthase
GIS01_RS06645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GIS01_RS06655	COG0009	L-threonylcarbamoyladenylate synthase
GIS01_RS06665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GIS01_RS06680	COG1946	Acyl-CoA thioesterase
GIS01_RS06685	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GIS01_RS06690	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GIS01_RS06705	COG0083	homoserine kinase activity
GIS01_RS06710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GIS01_RS06730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GIS01_RS06750	COG1342	Belongs to the UPF0251 family
GIS01_RS06765	COG1309	transcriptional regulator
GIS01_RS06770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_RS06775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_RS06785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GIS01_RS06790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GIS01_RS06800	COG1091	dTDP-4-dehydrorhamnose reductase activity
GIS01_RS06820	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GIS01_RS06825	COG2030	dehydratase
GIS01_RS06855	COG1216	Glycosyl transferase, family 2
GIS01_RS06860	COG0482	sulfurtransferase activity
GIS01_RS06865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GIS01_RS06875	COG1086	Polysaccharide biosynthesis protein
GIS01_RS06900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GIS01_RS06920	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GIS01_RS06930	COG0489	protein tyrosine kinase activity
GIS01_RS06930	COG3206	protein involved in exopolysaccharide biosynthesis
GIS01_RS06950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GIS01_RS06965	COG1538	Outer membrane efflux protein
GIS01_RS06970	COG0577	efflux transmembrane transporter activity
GIS01_RS06970	COG1136	(ABC) transporter
GIS01_RS06975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_RS06980	COG1227	inorganic diphosphatase activity
GIS01_RS06985	COG0497	DNA recombination
GIS01_RS06990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GIS01_RS06995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GIS01_RS07000	COG0443	Heat shock 70 kDa protein
GIS01_RS07005	COG0484	heat shock protein binding
GIS01_RS07035	COG1285	pathogenesis
GIS01_RS07065	COG2391	methyltransferase activity
GIS01_RS07080	COG1566	PFAM secretion protein HlyD family protein
GIS01_RS07085	COG1136	(ABC) transporter
GIS01_RS07085	COG0577	efflux transmembrane transporter activity
GIS01_RS07090	COG0577	efflux transmembrane transporter activity
GIS01_RS07090	COG1136	(ABC) transporter
GIS01_RS07095	COG1136	(ABC) transporter
GIS01_RS07095	COG0577	efflux transmembrane transporter activity
GIS01_RS07105	COG0095	Lipoate-protein ligase
GIS01_RS07115	COG0702	epimerase
GIS01_RS07120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GIS01_RS07125	COG1454	alcohol dehydrogenase
GIS01_RS07135	COG0564	pseudouridine synthase activity
GIS01_RS07170	COG1280	lysine exporter protein (LysE YggA)
GIS01_RS07185	COG3263	regulation of cellular component size
GIS01_RS07195	COG1876	peptidase activity
GIS01_RS07200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GIS01_RS07205	COG1393	Belongs to the ArsC family
GIS01_RS07215	COG3069	C4-dicarboxylate transmembrane transporter activity
GIS01_RS07220	COG1473	amidohydrolase
GIS01_RS07230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GIS01_RS07240	COG0017	Asparaginyl-tRNA synthetase
GIS01_RS07255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GIS01_RS07260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GIS01_RS07265	COG0156	8-amino-7-oxononanoate synthase activity
GIS01_RS07270	COG2226	methyltransferase
GIS01_RS07270	COG1073	alpha beta
GIS01_RS07275	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GIS01_RS07280	COG0501	Belongs to the peptidase M48B family
GIS01_RS07290	COG3217	Mosc domain protein beta barrel domain protein
GIS01_RS07290	COG0633	Ferredoxin
GIS01_RS07290	COG3217	Mosc domain protein beta barrel domain protein
GIS01_RS07290	COG0633	Ferredoxin
GIS01_RS07305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GIS01_RS07305	COG0674	pyruvate-flavodoxin oxidoreductase activity
GIS01_RS07305	COG1013	pyruvate-flavodoxin oxidoreductase activity
GIS01_RS07305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GIS01_RS07315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GIS01_RS07320	COG1607	acyl-coa hydrolase
GIS01_RS07330	COG3021	interspecies interaction between organisms
GIS01_RS07335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GIS01_RS07340	COG2027	D-alanyl-D-alanine carboxypeptidase
GIS01_RS07345	COG1061	Type III restriction enzyme res subunit
GIS01_RS07350	COG1566	PFAM secretion protein HlyD family protein
GIS01_RS07360	COG1966	Carbon starvation protein
GIS01_RS07365	COG3279	Response regulator of the LytR AlgR family
GIS01_RS07370	COG3275	phosphorelay sensor kinase activity
GIS01_RS07375	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_RS07375	COG2199	diguanylate cyclase activity
GIS01_RS07385	COG1940	carbohydrate kinase activity
GIS01_RS07385	COG1846	Transcriptional regulator
GIS01_RS07390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GIS01_RS07395	COG0363	glucosamine-6-phosphate deaminase activity
GIS01_RS07400	COG1263	PTS System
GIS01_RS07400	COG2190	(PTS) system
GIS01_RS07400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GIS01_RS07410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GIS01_RS07415	COG0735	belongs to the Fur family
GIS01_RS07425	COG0716	FMN binding
GIS01_RS07440	COG0596	Alpha beta hydrolase
GIS01_RS07445	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GIS01_RS07450	COG0033	Phosphoglucomutase
GIS01_RS07460	COG1846	Transcriptional regulator
GIS01_RS07465	COG2951	lytic endotransglycosylase activity
GIS01_RS07470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GIS01_RS07475	COG4136	ATPase activity
GIS01_RS07485	COG4134	Bacterial extracellular solute-binding protein
GIS01_RS07495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GIS01_RS07505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GIS01_RS07515	COG0729	surface antigen
GIS01_RS07520	COG2911	Protein conserved in bacteria
GIS01_RS07540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GIS01_RS07550	COG0741	lytic transglycosylase activity
GIS01_RS07560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GIS01_RS07565	COG4771	TonB-dependent receptor
GIS01_RS07570	COG1169	isochorismate synthase
GIS01_RS07575	COG1021	2,3-dihydroxybenzoate-AMP ligase
GIS01_RS07580	COG1535	isochorismatase
GIS01_RS07580	COG3433	isochorismatase activity
GIS01_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_RS07590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GIS01_RS07590	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GIS01_RS07615	COG1278	Cold shock
GIS01_RS07640	COG4166	transmembrane transport
GIS01_RS07645	COG1349	DNA-binding transcription factor activity
GIS01_RS07655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GIS01_RS07660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GIS01_RS07670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_RS07675	COG1187	pseudouridine synthase activity
GIS01_RS07685	COG4166	transmembrane transport
GIS01_RS07690	COG0622	Phosphoesterase
GIS01_RS07705	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GIS01_RS07710	COG0835	chemotaxis
GIS01_RS07710	COG0784	Response regulator, receiver
GIS01_RS07715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GIS01_RS07720	COG1815	bacterial-type flagellum-dependent cell motility
GIS01_RS07725	COG1558	bacterial-type flagellum-dependent cell motility
GIS01_RS07730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GIS01_RS07740	COG4787	bacterial-type flagellum-dependent cell motility
GIS01_RS07745	COG4786	Flagellar basal body rod
GIS01_RS07750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GIS01_RS07755	COG1706	bacterial-type flagellum-dependent cell motility
GIS01_RS07770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_RS07775	COG2239	Acts as a magnesium transporter
GIS01_RS07780	COG0248	Ppx GppA phosphatase
GIS01_RS07785	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GIS01_RS07790	COG2716	regulation of RNA biosynthetic process
GIS01_RS07800	COG2204	response regulator
GIS01_RS07805	COG3852	Histidine kinase
GIS01_RS07810	COG2204	response regulator
GIS01_RS07815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GIS01_RS07820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GIS01_RS07825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GIS01_RS07830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GIS01_RS07850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GIS01_RS07860	COG0590	tRNA wobble adenosine to inosine editing
GIS01_RS07865	COG0573	inorganic phosphate transmembrane transporter activity
GIS01_RS07870	COG0581	inorganic phosphate transmembrane transporter activity
GIS01_RS07880	COG0704	Plays a role in the regulation of phosphate uptake
GIS01_RS07885	COG1253	flavin adenine dinucleotide binding
GIS01_RS07900	COG0531	amino acid
GIS01_RS07915	COG1126	abc transporter atp-binding protein
GIS01_RS07920	COG0765	amino acid transport
GIS01_RS07925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_RS07930	COG3706	GGDEF domain
GIS01_RS07935	COG2271	Major facilitator Superfamily
GIS01_RS07945	COG2197	response regulator
GIS01_RS07950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GIS01_RS07970	COG1785	Belongs to the alkaline phosphatase family
GIS01_RS07975	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GIS01_RS07980	COG0123	including yeast histone deacetylase and acetoin utilization protein
GIS01_RS07990	COG1199	ATP-dependent helicase activity
GIS01_RS08000	COG0287	Prephenate dehydrogenase
GIS01_RS08000	COG1605	Chorismate mutase
GIS01_RS08005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GIS01_RS08015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GIS01_RS08020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GIS01_RS08055	COG0537	adenosine 5'-monophosphoramidase activity
GIS01_RS08070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GIS01_RS08085	COG1301	dicarboxylic acid transport
GIS01_RS08100	COG2354	Protein conserved in bacteria
GIS01_RS08110	COG2233	PERMEase
GIS01_RS08120	COG1252	NADH dehydrogenase
GIS01_RS08130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GIS01_RS08135	COG5001	Diguanylate cyclase
GIS01_RS08135	COG3300	MHYT domain
GIS01_RS08140	COG0446	pyridine nucleotide-disulphide oxidoreductase
GIS01_RS08150	COG2373	Large extracellular alpha-helical protein
GIS01_RS08155	COG4953	penicillin-binding protein 1C
GIS01_RS08185	COG0328	RNA-DNA hybrid ribonuclease activity
GIS01_RS08225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GIS01_RS08255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GIS01_RS08255	COG0301	tRNA thio-modification
GIS01_RS08275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_RS08280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_RS08285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_RS08290	COG1334	flagellar protein FlaG
GIS01_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_RS08320	COG1083	cytidylyl-transferase
GIS01_RS08325	COG0673	inositol 2-dehydrogenase activity
GIS01_RS08335	COG2030	dehydratase
GIS01_RS08345	COG2089	acid synthase
GIS01_RS08350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GIS01_RS08355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GIS01_RS08380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GIS01_RS08395	COG0483	inositol monophosphate 1-phosphatase activity
GIS01_RS08405	COG0625	glutathione transferase activity
GIS01_RS08410	COG2814	Major facilitator Superfamily
GIS01_RS08415	COG0583	DNA-binding transcription factor activity
GIS01_RS08420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GIS01_RS08425	COG0243	molybdopterin cofactor binding
GIS01_RS08435	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GIS01_RS08445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GIS01_RS08450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GIS01_RS08460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GIS01_RS08465	COG0509	glycine decarboxylation via glycine cleavage system
GIS01_RS08470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GIS01_RS08470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GIS01_RS08475	COG0840	transmembrane signaling receptor activity
GIS01_RS08505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GIS01_RS08510	COG0574	Belongs to the PEP-utilizing enzyme family
GIS01_RS08510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GIS01_RS08525	COG1464	Belongs to the NlpA lipoprotein family
GIS01_RS08530	COG3083	sulfuric ester hydrolase activity
GIS01_RS08535	COG3082	Protein of unknown function (DUF1414)
GIS01_RS08540	COG3081	Nucleoid-associated protein
GIS01_RS08550	COG1175	transmembrane transport
GIS01_RS08560	COG3842	ATPase activity
GIS01_RS08590	COG4783	chaperone-mediated protein folding
GIS01_RS08600	COG1393	Belongs to the ArsC family
GIS01_RS08615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_RS08620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GIS01_RS08625	COG2431	L-lysine efflux transmembrane transporter activity
GIS01_RS08635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_RS08640	COG4215	(ABC) transporter
GIS01_RS08645	COG4160	amino acid transport
GIS01_RS08650	COG0564	pseudouridine synthase activity
GIS01_RS08665	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GIS01_RS08675	COG0625	glutathione transferase activity
GIS01_RS08685	COG0367	asparagine synthase
GIS01_RS08695	COG4651	solute:proton antiporter activity
GIS01_RS08695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GIS01_RS08700	COG0647	UMP catabolic process
GIS01_RS08705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GIS01_RS08715	COG1902	pentaerythritol trinitrate reductase activity
GIS01_RS08720	COG1253	flavin adenine dinucleotide binding
GIS01_RS08730	COG0247	lactate metabolic process
GIS01_RS08730	COG0277	FAD linked oxidase domain protein
GIS01_RS08740	COG2050	protein possibly involved in aromatic compounds catabolism
GIS01_RS08750	COG2056	Na+-H+ antiporter family
GIS01_RS08755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GIS01_RS08760	COG0671	phosphoesterase, PA-phosphatase related
GIS01_RS08765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GIS01_RS08770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GIS01_RS08780	COG0101	tRNA pseudouridine synthase activity
GIS01_RS08785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GIS01_RS08790	COG0285	dihydrofolate synthase activity
GIS01_RS08795	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GIS01_RS08800	COG0393	Putative heavy-metal-binding
GIS01_RS08810	COG1648	precorrin-2 dehydrogenase activity
GIS01_RS08810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GIS01_RS08815	COG2221	Nitrite and sulphite reductase 4Fe-4S
GIS01_RS08830	COG4667	esterase of the alpha-beta hydrolase superfamily
GIS01_RS08835	COG1619	proteins homologs of microcin C7 resistance protein MccF
GIS01_RS08840	COG1368	sulfuric ester hydrolase activity
GIS01_RS08850	COG0527	aspartate kinase activity
GIS01_RS08855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GIS01_RS08855	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GIS01_RS08860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GIS01_RS08930	COG0596	Alpha beta hydrolase
GIS01_RS08960	COG1136	(ABC) transporter
GIS01_RS08975	COG2814	Major facilitator Superfamily
GIS01_RS08995	COG0672	)-iron permease
GIS01_RS09035	COG0659	secondary active sulfate transmembrane transporter activity
GIS01_RS09065	COG1629	transport
GIS01_RS09065	COG4771	TonB-dependent receptor
GIS01_RS09085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GIS01_RS09090	COG0326	Molecular chaperone. Has ATPase activity
GIS01_RS09095	COG4172	Belongs to the ABC transporter superfamily
GIS01_RS09100	COG4172	Belongs to the ABC transporter superfamily
GIS01_RS09105	COG4171	peptide transport system, permease
GIS01_RS09110	COG4168	peptide transport system, permease
GIS01_RS09120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GIS01_RS09125	COG1842	Phage shock protein A
GIS01_RS09140	COG3106	COG3106 Predicted ATPase
GIS01_RS09145	COG3768	UPF0283 membrane protein
GIS01_RS09150	COG0583	DNA-binding transcription factor activity
GIS01_RS09155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GIS01_RS09160	COG3842	ATPase activity
GIS01_RS09165	COG1176	ABC-type spermidine putrescine transport system, permease component I
GIS01_RS09170	COG1177	transmembrane transport
GIS01_RS09175	COG1012	belongs to the aldehyde dehydrogenase family
GIS01_RS09185	COG2154	pterin-4-alpha-carbinolamine dehydratase
GIS01_RS09205	COG2199	diguanylate cyclase activity
GIS01_RS09210	COG2885	chlorophyll binding
GIS01_RS09215	COG0861	Integral membrane protein TerC family
GIS01_RS09245	COG2910	NAD(P)H-binding
GIS01_RS09250	COG0583	DNA-binding transcription factor activity
GIS01_RS09255	COG0583	DNA-binding transcription factor activity
GIS01_RS09270	COG1335	isochorismatase
GIS01_RS09280	COG0583	DNA-binding transcription factor activity
GIS01_RS09285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GIS01_RS09295	COG0583	DNA-binding transcription factor activity
GIS01_RS09300	COG2723	6-phospho-beta-galactosidase activity
GIS01_RS09305	COG1944	ATP diphosphatase activity
GIS01_RS09310	COG2116	formate transmembrane transporter activity
GIS01_RS09315	COG1882	Formate acetyltransferase
GIS01_RS09325	COG4166	transmembrane transport
GIS01_RS09330	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GIS01_RS09335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GIS01_RS09345	COG4591	ABC-type transport system involved in lipoprotein release permease component
GIS01_RS09350	COG1136	(ABC) transporter
GIS01_RS09355	COG4591	ABC-type transport system involved in lipoprotein release permease component
GIS01_RS09360	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GIS01_RS09370	COG0544	peptidyl-prolyl cis-trans isomerase activity
GIS01_RS09375	COG0740	serine-type endopeptidase activity
GIS01_RS09380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GIS01_RS09385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GIS01_RS09390	COG0776	regulation of translation
GIS01_RS09395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GIS01_RS09400	COG0488	(ABC) transporter
GIS01_RS09405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GIS01_RS09410	COG3162	membrane
GIS01_RS09425	COG1024	Enoyl-CoA hydratase
GIS01_RS09430	COG4695	Portal protein
GIS01_RS09475	COG1115	amino acid carrier protein
GIS01_RS09490	COG1584	GPR1 FUN34 yaaH family protein
GIS01_RS09520	COG1024	Enoyl-CoA hydratase
GIS01_RS09525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GIS01_RS09530	COG1960	acyl-CoA dehydrogenase activity
GIS01_RS09535	COG1960	acyl-CoA dehydrogenase activity
GIS01_RS09540	COG1024	Enoyl-CoA hydratase
GIS01_RS09545	COG1024	Enoyl-CoA hydratase
GIS01_RS09555	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_RS09565	COG0730	response to heat
GIS01_RS09590	COG2826	transposase and inactivated derivatives, IS30 family
GIS01_RS09600	COG5001	Diguanylate cyclase
GIS01_RS09600	COG5002	protein histidine kinase activity
GIS01_RS09620	COG2003	Belongs to the UPF0758 family
GIS01_RS09635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GIS01_RS09685	COG3850	Histidine kinase
GIS01_RS09685	COG2205	protein histidine kinase activity
GIS01_RS09685	COG4999	Histidine kinase
GIS01_RS09685	COG3437	response regulator, receiver
GIS01_RS09725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GIS01_RS09730	COG1215	transferase activity, transferring glycosyl groups
GIS01_RS09735	COG0438	transferase activity, transferring glycosyl groups
GIS01_RS09780	COG0438	transferase activity, transferring glycosyl groups
GIS01_RS09800	COG0438	transferase activity, transferring glycosyl groups
GIS01_RS09805	COG0438	transferase activity, transferring glycosyl groups
GIS01_RS09810	COG5001	Diguanylate cyclase
GIS01_RS09810	COG4251	negative regulation of phosphorylation
GIS01_RS09810	COG3706	GGDEF domain
GIS01_RS09810	COG2203	Gaf domain
GIS01_RS09815	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_RS09820	COG3437	response regulator, receiver
GIS01_RS09825	COG2205	protein histidine kinase activity
GIS01_RS09825	COG4999	Histidine kinase
GIS01_RS09825	COG3437	response regulator, receiver
GIS01_RS09825	COG3850	Histidine kinase
GIS01_RS09830	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GIS01_RS09835	COG0437	4 iron, 4 sulfur cluster binding
GIS01_RS09840	COG5557	Pfam Polysulphide reductase, NrfD
GIS01_RS09845	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GIS01_RS09850	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GIS01_RS09855	COG1773	rubredoxin
GIS01_RS09870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GIS01_RS09880	COG3842	ATPase activity
GIS01_RS09885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GIS01_RS09890	COG0375	protein maturation
GIS01_RS09895	COG0309	Hydrogenase expression formation protein (HypE)
GIS01_RS09905	COG0298	carbon dioxide binding
GIS01_RS09910	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GIS01_RS09920	COG1921	L-seryl-tRNASec selenium transferase activity
GIS01_RS09930	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GIS01_RS09940	COG3260	NADH ubiquinone oxidoreductase 20
GIS01_RS09945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_RS09950	COG3261	NADH dehydrogenase
GIS01_RS09950	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GIS01_RS09955	COG0650	Formate hydrogenlyase subunit 4
GIS01_RS09960	COG0651	ATP synthesis coupled electron transport
GIS01_RS09965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GIS01_RS09970	COG3158	transport of potassium into the cell
GIS01_RS09985	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GIS01_RS10010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GIS01_RS10015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_RS10020	COG3046	protein related to deoxyribodipyrimidine photolyase
GIS01_RS10030	COG3033	Beta-eliminating lyase
GIS01_RS10035	COG0295	cytidine deaminase activity
GIS01_RS10040	COG1346	cytolysis
GIS01_RS10045	COG1380	Effector of murein hydrolase LrgA
GIS01_RS10050	COG3345	alpha-galactosidase
GIS01_RS10060	COG2925	Exonuclease
GIS01_RS10070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_RS10080	COG1643	Atp-dependent helicase
GIS01_RS10090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GIS01_RS10105	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GIS01_RS10110	COG2067	long-chain fatty acid transport protein
GIS01_RS10115	COG2067	long-chain fatty acid transport protein
GIS01_RS10125	COG1595	DNA-templated transcription, initiation
GIS01_RS10135	COG2304	oxidoreductase activity
GIS01_RS10155	COG0714	Associated with various cellular activities
GIS01_RS10160	COG0183	Belongs to the thiolase family
GIS01_RS10165	COG1024	Enoyl-CoA hydratase
GIS01_RS10165	COG1250	3-hydroxyacyl-CoA dehydrogenase
GIS01_RS10170	COG2719	SpoVR family
GIS01_RS10175	COG2718	Belongs to the UPF0229 family
GIS01_RS10180	COG2766	serine protein kinase
GIS01_RS10185	COG0514	ATP-dependent DNA helicase (RecQ)
GIS01_RS10190	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GIS01_RS10200	COG0814	amino acid
GIS01_RS10205	COG0494	nUDIX hydrolase
GIS01_RS10220	COG2824	Alkylphosphonate utilization operon protein PhnA
GIS01_RS10235	COG0406	alpha-ribazole phosphatase activity
GIS01_RS10240	COG3706	GGDEF domain
GIS01_RS10245	COG2840	Smr protein MutS2
GIS01_RS10250	COG2890	protein-(glutamine-N5) methyltransferase activity
GIS01_RS10255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GIS01_RS10265	COG0513	Belongs to the DEAD box helicase family
GIS01_RS10275	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GIS01_RS10290	COG0814	amino acid
GIS01_RS10295	COG1609	Transcriptional regulator
GIS01_RS10300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_RS10300	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_RS10305	COG1105	Belongs to the carbohydrate kinase PfkB family
GIS01_RS10310	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GIS01_RS10310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_RS10310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_RS10315	COG3313	Fe-S protein
GIS01_RS10320	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GIS01_RS10325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GIS01_RS10330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GIS01_RS10335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GIS01_RS10345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GIS01_RS10355	COG0366	Alpha amylase catalytic
GIS01_RS10370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GIS01_RS10375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GIS01_RS10380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GIS01_RS10385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GIS01_RS10390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GIS01_RS10395	COG0072	phenylalanine-tRNA ligase activity
GIS01_RS10395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIS01_RS10400	COG0776	regulation of translation
GIS01_RS10405	COG2205	protein histidine kinase activity
GIS01_RS10405	COG0784	Response regulator, receiver
GIS01_RS10420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GIS01_RS10430	COG3300	MHYT domain
GIS01_RS10430	COG5001	Diguanylate cyclase
GIS01_RS10435	COG1609	Transcriptional regulator
GIS01_RS10440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIS01_RS10445	COG1879	ABC-type sugar transport system periplasmic component
GIS01_RS10450	COG1172	Belongs to the binding-protein-dependent transport system permease family
GIS01_RS10455	COG1129	ABC transporter
GIS01_RS10460	COG1869	D-ribose catabolic process
GIS01_RS10465	COG0625	glutathione transferase activity
GIS01_RS10475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GIS01_RS10480	COG1177	transmembrane transport
GIS01_RS10485	COG1176	ABC-type spermidine putrescine transport system, permease component I
GIS01_RS10505	COG0037	tRNA processing
GIS01_RS10510	COG0589	response to stress
GIS01_RS10515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GIS01_RS10530	COG2217	Heavy metal translocating P-type atpase
GIS01_RS10540	COG2010	Cytochrome c
GIS01_RS10555	COG3278	Belongs to the heme-copper respiratory oxidase family
GIS01_RS10565	COG1956	GAF domain-containing protein
GIS01_RS10570	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GIS01_RS10580	COG0308	aminopeptidase N
GIS01_RS10590	COG2902	Dehydrogenase
GIS01_RS10595	COG0167	dihydroorotate dehydrogenase activity
GIS01_RS10605	COG0254	rRNA binding
GIS01_RS10610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GIS01_RS10615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GIS01_RS10615	COG0116	Belongs to the methyltransferase superfamily
GIS01_RS10625	COG0488	(ABC) transporter
GIS01_RS10635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GIS01_RS10640	COG1067	ATP-dependent peptidase activity
GIS01_RS10670	COG3141	response to X-ray
GIS01_RS10675	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GIS01_RS10680	COG4221	oxidoreductase activity
GIS01_RS10725	COG0372	Belongs to the citrate synthase family
GIS01_RS10730	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GIS01_RS10740	COG2995	paraquat-inducible protein a
GIS01_RS10745	COG3008	intermembrane lipid transfer
GIS01_RS10750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GIS01_RS10750	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GIS01_RS10765	COG0084	hydrolase, TatD family'
GIS01_RS10770	COG0470	DNA polymerase III
GIS01_RS10775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GIS01_RS10780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GIS01_RS10785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GIS01_RS10790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GIS01_RS10795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GIS01_RS10800	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_RS10810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GIS01_RS10815	COG0416	fatty acid biosynthetic process
GIS01_RS10820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GIS01_RS10825	COG1399	metal-binding, possibly nucleic acid-binding protein
GIS01_RS10950	COG2916	Histone family protein nucleoid-structuring protein H-NS
GIS01_RS10955	COG2200	EAL domain
GIS01_RS11110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GIS01_RS11120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GIS01_RS11130	COG0582	viral genome integration into host DNA
GIS01_RS11135	COG0424	maF-like protein
GIS01_RS11150	COG1530	ribonuclease E activity
GIS01_RS11160	COG0306	phosphate transporter
GIS01_RS11165	COG0717	Belongs to the dCTP deaminase family
GIS01_RS11170	COG0572	uridine kinase
GIS01_RS11175	COG0489	protein tyrosine kinase activity
GIS01_RS11180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIS01_RS11180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIS01_RS11190	COG1254	Belongs to the acylphosphatase family
GIS01_RS11195	COG0840	transmembrane signaling receptor activity
GIS01_RS11200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GIS01_RS11215	COG0709	Synthesizes selenophosphate from selenide and ATP
GIS01_RS11220	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GIS01_RS11225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GIS01_RS11235	COG0318	PFAM AMP-dependent synthetase and ligase
GIS01_RS11240	COG2267	carboxylic ester hydrolase activity
GIS01_RS11250	COG1214	PFAM Peptidase M22, glycoprotease
GIS01_RS11255	COG1199	ATP-dependent helicase activity
GIS01_RS11265	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GIS01_RS11270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GIS01_RS11275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GIS01_RS11280	COG0131	Imidazoleglycerol-phosphate dehydratase
GIS01_RS11280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GIS01_RS11285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GIS01_RS11290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GIS01_RS11295	COG0107	imidazoleglycerol-phosphate synthase activity
GIS01_RS11310	COG3706	GGDEF domain
GIS01_RS11315	COG0318	PFAM AMP-dependent synthetase and ligase
GIS01_RS11325	COG3134	Outer membrane lipoprotein
GIS01_RS11330	COG2080	2 iron, 2 sulfur cluster binding
GIS01_RS11335	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GIS01_RS11340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GIS01_RS11345	COG2252	PERMEase
GIS01_RS11350	COG0402	S-adenosylhomocysteine deaminase activity
GIS01_RS11355	COG2233	PERMEase
GIS01_RS11360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GIS01_RS11360	COG2080	2 iron, 2 sulfur cluster binding
GIS01_RS11365	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GIS01_RS11370	COG0402	S-adenosylhomocysteine deaminase activity
GIS01_RS11375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GIS01_RS11375	COG0493	'glutamate synthase
GIS01_RS11385	COG2068	MobA-Related Protein
GIS01_RS11390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GIS01_RS11395	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GIS01_RS11395	COG3608	succinylglutamate desuccinylase aspartoacylase
GIS01_RS11405	COG0697	spore germination
GIS01_RS11410	COG0549	Belongs to the carbamate kinase family
GIS01_RS11420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GIS01_RS11425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GIS01_RS11430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GIS01_RS11465	COG0242	peptide deformylase activity
GIS01_RS11475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GIS01_RS11480	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GIS01_RS11485	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GIS01_RS11495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GIS01_RS11500	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GIS01_RS11510	COG0205	6-phosphofructokinase activity
GIS01_RS11520	COG3123	guanosine phosphorylase activity
GIS01_RS11525	COG1760	l-serine dehydratase
GIS01_RS11530	COG1760	l-serine dehydratase
GIS01_RS11535	COG3100	YcgL domain-containing protein
GIS01_RS11540	COG0850	regulation of cytokinetic process
GIS01_RS11545	COG2894	cell division
GIS01_RS11550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GIS01_RS11560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GIS01_RS11600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GIS01_RS11605	COG0697	spore germination
GIS01_RS11610	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GIS01_RS11615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GIS01_RS11625	COG0307	riboflavin synthase, alpha
GIS01_RS11640	COG0534	Mate efflux family protein
GIS01_RS11685	COG4681	YaeQ
GIS01_RS11700	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GIS01_RS11705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GIS01_RS11710	COG0586	Pfam SNARE associated Golgi protein
GIS01_RS11720	COG0556	nucleotide-excision repair
GIS01_RS11735	COG0569	domain protein
GIS01_RS11735	COG2985	domain, Protein
GIS01_RS11745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GIS01_RS11750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_RS11750	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GIS01_RS11765	COG3069	C4-dicarboxylate transmembrane transporter activity
GIS01_RS11780	COG1451	nucleotide metabolic process
GIS01_RS11795	COG0417	DNA replication proofreading
GIS01_RS11820	COG1560	Kdo2-lipid A biosynthetic process
GIS01_RS11825	COG1560	Kdo2-lipid A biosynthetic process
GIS01_RS11840	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GIS01_RS11845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GIS01_RS11855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GIS01_RS11860	COG2832	Protein of unknown function (DUF454)
GIS01_RS11865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GIS01_RS11880	COG1011	Hydrolase
GIS01_RS11885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GIS01_RS11910	COG3593	DNA synthesis involved in DNA repair
GIS01_RS11925	COG0583	DNA-binding transcription factor activity
GIS01_RS11930	COG0730	response to heat
GIS01_RS11940	COG1846	Transcriptional regulator
GIS01_RS11940	COG1940	carbohydrate kinase activity
GIS01_RS11945	COG0840	transmembrane signaling receptor activity
GIS01_RS11950	COG3012	SEC-C Motif Domain Protein
GIS01_RS11955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GIS01_RS11960	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GIS01_RS11965	COG0247	lactate metabolic process
GIS01_RS11980	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GIS01_RS11985	COG0437	4 iron, 4 sulfur cluster binding
GIS01_RS11990	COG3301	Polysulphide reductase, NrfD
GIS01_RS11995	COG1138	Cytochrome C-type biogenesis protein
GIS01_RS12000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GIS01_RS12005	COG4235	cytochrome complex assembly
GIS01_RS12005	COG3088	subunit of a heme lyase
GIS01_RS12015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GIS01_RS12025	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GIS01_RS12035	COG1840	ABC-type Fe3 transport system, periplasmic component
GIS01_RS12040	COG3842	ATPase activity
GIS01_RS12050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_RS12070	COG0045	succinate-CoA ligase (ADP-forming) activity
GIS01_RS12075	COG0508	dehydrogenase complex catalyzes the overall conversion of
GIS01_RS12080	COG0567	Dehydrogenase, E1 component
GIS01_RS12090	COG1053	succinate dehydrogenase
GIS01_RS12095	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GIS01_RS12100	COG2009	succinate dehydrogenase
GIS01_RS12115	COG0456	acetyltransferase
GIS01_RS12135	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GIS01_RS12150	COG2501	S4 domain
GIS01_RS12160	COG1132	(ABC) transporter
GIS01_RS12165	COG1132	(ABC) transporter
GIS01_RS12175	COG3118	belongs to the thioredoxin family
GIS01_RS12180	COG0471	metal ion transport
GIS01_RS12185	COG0058	SHG alpha-glucan phosphorylase activity
GIS01_RS12200	COG0697	spore germination
GIS01_RS12210	COG2062	phosphohistidine phosphatase, SixA
GIS01_RS12215	COG1025	Belongs to the peptidase M16 family
GIS01_RS12220	COG0500	methyltransferase
GIS01_RS12240	COG1129	ABC transporter
GIS01_RS12250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GIS01_RS12250	COG0519	Catalyzes the synthesis of GMP from XMP
GIS01_RS12255	COG0517	IMP dehydrogenase activity
GIS01_RS12255	COG0516	GMP reductase activity
GIS01_RS12265	COG1570	exodeoxyribonuclease VII activity
GIS01_RS12270	COG2188	Transcriptional regulator
GIS01_RS12280	COG0383	alpha-mannosidase activity
GIS01_RS12285	COG1181	Belongs to the D-alanine--D-alanine ligase family
GIS01_RS12295	COG0386	Belongs to the glutathione peroxidase family
GIS01_RS12300	COG0513	Belongs to the DEAD box helicase family
GIS01_RS12315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GIS01_RS12320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GIS01_RS12325	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GIS01_RS12345	COG0598	Magnesium transport protein CorA
GIS01_RS12375	COG5001	Diguanylate cyclase
GIS01_RS12375	COG3300	MHYT domain
GIS01_RS12390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIS01_RS12400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GIS01_RS12405	COG0563	adenylate kinase activity
GIS01_RS12415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GIS01_RS12420	COG1286	toxin biosynthetic process
GIS01_RS12425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GIS01_RS12430	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GIS01_RS12435	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GIS01_RS12440	COG1674	ftsk spoiiie
GIS01_RS12440	COG0531	amino acid
GIS01_RS12450	COG0686	Belongs to the AlaDH PNT family
GIS01_RS12455	COG0492	ferredoxin-NADP+ reductase activity
GIS01_RS12460	COG3706	GGDEF domain
GIS01_RS12465	COG3134	Outer membrane lipoprotein
GIS01_RS12470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GIS01_RS12475	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GIS01_RS12480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GIS01_RS12485	COG0542	response to heat
GIS01_RS12490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GIS01_RS12495	COG1278	Cold shock
GIS01_RS12500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GIS01_RS12520	COG0745	RESPONSE REGULATOR receiver
GIS01_RS12525	COG2205	protein histidine kinase activity
GIS01_RS12535	COG0392	lysyltransferase activity
GIS01_RS12535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GIS01_RS12560	COG1435	thymidine kinase activity
GIS01_RS12565	COG1757	Na H antiporter
GIS01_RS12570	COG2916	Histone family protein nucleoid-structuring protein H-NS
GIS01_RS12575	COG2096	Adenosyltransferase
GIS01_RS12580	COG3530	Putative quorum-sensing-regulated virulence factor
GIS01_RS12585	COG0602	queuosine metabolic process
GIS01_RS12590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GIS01_RS12610	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GIS01_RS12620	COG0776	regulation of translation
GIS01_RS12625	COG0539	negative regulation of cytoplasmic translation
GIS01_RS12630	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GIS01_RS12635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GIS01_RS12650	COG2814	Major facilitator Superfamily
GIS01_RS12665	COG0778	Nitroreductase
GIS01_RS12670	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GIS01_RS12675	COG5001	Diguanylate cyclase
GIS01_RS12675	COG3300	MHYT domain
GIS01_RS12680	COG0583	DNA-binding transcription factor activity
GIS01_RS12685	COG3437	response regulator, receiver
GIS01_RS12710	COG4989	oxidoreductase activity
GIS01_RS12715	COG0724	RNA recognition motif
GIS01_RS12725	COG1126	abc transporter atp-binding protein
GIS01_RS12730	COG0765	amino acid transport
GIS01_RS12735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_RS12740	COG4597	amino acid ABC transporter
GIS01_RS12745	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GIS01_RS12755	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GIS01_RS12770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GIS01_RS12775	COG1360	Flagellar Motor Protein
GIS01_RS12785	COG1770	oligopeptidase
GIS01_RS12805	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_RS12810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_RS12815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_RS12815	COG0649	NAD binding
GIS01_RS12830	COG1034	ATP synthesis coupled electron transport
GIS01_RS12835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GIS01_RS12840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_RS12845	COG0839	Belongs to the complex I subunit 6 family
GIS01_RS12850	COG0713	ATP synthesis coupled electron transport
GIS01_RS12860	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_RS12865	COG1007	ATP synthesis coupled electron transport
GIS01_RS12880	COG2199	diguanylate cyclase activity
GIS01_RS12880	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_RS12885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GIS01_RS12885	COG0047	phosphoribosylformylglycinamidine synthase activity
GIS01_RS12890	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GIS01_RS12895	COG1645	bacterial-type flagellum-dependent swarming motility
GIS01_RS12900	COG1160	GTP binding
GIS01_RS12905	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GIS01_RS12910	COG2976	Protein conserved in bacteria
GIS01_RS12915	COG0124	histidyl-tRNA synthetase
GIS01_RS12935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GIS01_RS12940	COG0105	UTP biosynthetic process
GIS01_RS12955	COG0633	Ferredoxin
GIS01_RS12960	COG0443	Heat shock 70 kDa protein
GIS01_RS12965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GIS01_RS12975	COG0822	iron-sulfur transferase activity
GIS01_RS12980	COG1104	cysteine desulfurase activity
GIS01_RS13025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GIS01_RS13030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GIS01_RS13035	COG1862	Preprotein translocase
GIS01_RS13040	COG0343	queuine tRNA-ribosyltransferase activity
GIS01_RS13045	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GIS01_RS13050	COG0517	IMP dehydrogenase activity
GIS01_RS13055	COG0450	alkyl hydroperoxide reductase
GIS01_RS13060	COG3634	alkyl hydroperoxide reductase activity
GIS01_RS13105	COG1242	4 iron, 4 sulfur cluster binding
GIS01_RS13110	COG0067	glutamate synthase
GIS01_RS13110	COG0069	glutamate synthase activity
GIS01_RS13110	COG0070	glutamate synthase
GIS01_RS13115	COG0493	'glutamate synthase
GIS01_RS13125	COG0513	Belongs to the DEAD box helicase family
GIS01_RS13150	COG0023	Translation Initiation Factor
GIS01_RS13155	COG2119	membrane
GIS01_RS13205	COG0215	cysteine-tRNA ligase activity
GIS01_RS13210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GIS01_RS13220	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GIS01_RS13230	COG2261	transglycosylase associated protein
GIS01_RS13235	COG0642	Histidine kinase
GIS01_RS13280	COG0322	excinuclease ABC activity
GIS01_RS13285	COG2197	response regulator
GIS01_RS13290	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GIS01_RS13295	COG2835	tetraacyldisaccharide 4'-kinase activity
GIS01_RS13300	COG1663	tetraacyldisaccharide 4'-kinase activity
GIS01_RS13310	COG0658	competence protein
GIS01_RS13310	COG2333	competence protein COMEC
GIS01_RS13325	COG1448	Aminotransferase
GIS01_RS13350	COG0708	Exodeoxyribonuclease III
GIS01_RS13375	COG1122	ATPase activity
GIS01_RS13400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_RS13405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_RS13420	COG1120	ATPase activity
GIS01_RS13425	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GIS01_RS13430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GIS01_RS13435	COG4771	TonB-dependent receptor
GIS01_RS13440	COG2375	cellular response to nickel ion
GIS01_RS13445	COG3437	response regulator, receiver
GIS01_RS13445	COG0784	Response regulator, receiver
GIS01_RS13455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GIS01_RS13460	COG0328	RNA-DNA hybrid ribonuclease activity
GIS01_RS13465	COG2226	methyltransferase
GIS01_RS13470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GIS01_RS13475	COG1388	LysM domain
GIS01_RS13475	COG0741	lytic transglycosylase activity
GIS01_RS13500	COG5002	protein histidine kinase activity
GIS01_RS13500	COG5000	phosphorelay sensor kinase activity
GIS01_RS13505	COG0745	RESPONSE REGULATOR receiver
GIS01_RS13510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_RS13515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_RS13535	COG0583	DNA-binding transcription factor activity
GIS01_RS13540	COG3085	chromosome segregation
GIS01_RS13545	COG4574	serine-type endopeptidase inhibitor activity
GIS01_RS13550	COG0584	glycerophosphoryl diester phosphodiesterase
GIS01_RS13560	COG1349	DNA-binding transcription factor activity
GIS01_RS13565	COG2271	Major facilitator Superfamily
GIS01_RS13570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GIS01_RS13575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GIS01_RS13580	COG0840	transmembrane signaling receptor activity
GIS01_RS13590	COG0583	DNA-binding transcription factor activity
GIS01_RS13615	COG0656	L-ascorbic acid biosynthetic process
GIS01_RS13625	COG2814	Major facilitator Superfamily
GIS01_RS13630	COG2249	NAD(P)H dehydrogenase (quinone) activity
GIS01_RS13645	COG3220	belongs to the UPF0276 family
GIS01_RS13665	COG1294	oxidase, subunit
GIS01_RS13675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GIS01_RS13685	COG2979	Protein of unknown function (DUF533)
GIS01_RS13700	COG0583	DNA-binding transcription factor activity
GIS01_RS13710	COG2807	transmembrane transport
GIS01_RS13715	COG1187	pseudouridine synthase activity
GIS01_RS13725	COG0346	lactoylglutathione lyase activity
GIS01_RS13735	COG1061	Type III restriction enzyme res subunit
GIS01_RS13740	COG4657	Part of a membrane complex involved in electron transport
GIS01_RS13745	COG2878	Part of a membrane complex involved in electron transport
GIS01_RS13755	COG4658	electron transport chain
GIS01_RS13760	COG4659	FMN binding
GIS01_RS13770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GIS01_RS13775	COG0346	lactoylglutathione lyase activity
GIS01_RS13815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GIS01_RS13820	COG0505	Belongs to the CarA family
GIS01_RS13825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GIS01_RS13840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GIS01_RS13845	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GIS01_RS13850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GIS01_RS13855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GIS01_RS13860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GIS01_RS13865	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GIS01_RS13895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GIS01_RS13900	COG0861	Integral membrane protein TerC family
GIS01_RS13910	COG0444	Belongs to the ABC transporter superfamily
GIS01_RS13915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GIS01_RS13920	COG0601	transmembrane transport
GIS01_RS13930	COG2095	MarC family integral membrane protein
GIS01_RS13935	COG1454	alcohol dehydrogenase
GIS01_RS13935	COG1012	belongs to the aldehyde dehydrogenase family
GIS01_RS13945	COG0217	transcriptional regulatory protein
GIS01_RS13950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GIS01_RS13960	COG1801	Protein of unknown function DUF72
GIS01_RS13965	COG4106	trans-aconitate 2-methyltransferase activity
GIS01_RS13970	COG0500	methyltransferase
GIS01_RS13990	COG0450	alkyl hydroperoxide reductase
GIS01_RS13995	COG0583	DNA-binding transcription factor activity
GIS01_RS14000	COG0791	NLP P60 protein
GIS01_RS14010	COG0583	DNA-binding transcription factor activity
GIS01_RS14020	COG3048	D-serine ammonia-lyase activity
GIS01_RS14030	COG0538	isocitrate dehydrogenase activity
GIS01_RS14035	COG2207	Transcriptional regulator
GIS01_RS14040	COG1482	cell wall glycoprotein biosynthetic process
GIS01_RS14045	COG0840	transmembrane signaling receptor activity
GIS01_RS14050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_RS14065	COG3152	Membrane
GIS01_RS14100	COG1309	transcriptional regulator
GIS01_RS14130	COG0534	Mate efflux family protein
GIS01_RS14140	COG2841	Protein conserved in bacteria
GIS01_RS14145	COG1653	transport
GIS01_RS14150	COG3300	MHYT domain
GIS01_RS14150	COG5001	Diguanylate cyclase
GIS01_RS14155	COG3132	Protein of unknown function, DUF480
GIS01_RS14180	COG1388	LysM domain
GIS01_RS14180	COG1376	ErfK ybiS ycfS ynhG family protein
GIS01_RS14190	COG0471	metal ion transport
GIS01_RS14200	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GIS01_RS14205	COG0791	NLP P60 protein
GIS01_RS14215	COG3118	belongs to the thioredoxin family
GIS01_RS14225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GIS01_RS14230	COG0788	formyltetrahydrofolate deformylase activity
GIS01_RS14240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GIS01_RS14255	COG1196	nuclear chromosome segregation
GIS01_RS14255	COG0741	lytic transglycosylase activity
GIS01_RS14255	COG0739	heme binding
GIS01_RS14260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GIS01_RS14275	COG0436	Aminotransferase
GIS01_RS14280	COG1288	antiporter activity
GIS01_RS14285	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GIS01_RS14370	COG4397	Mu-like prophage major head subunit gpT
GIS01_RS14375	COG4388	Caudovirus prohead serine protease
GIS01_RS14405	COG4383	Mu-like prophage protein gp29
GIS01_RS14410	COG4373	Mu-like prophage FluMu protein gp28
GIS01_RS14420	COG0640	Transcriptional regulator
GIS01_RS14540	COG2932	Transcriptional regulator
GIS01_RS14555	COG2964	Protein conserved in bacteria
GIS01_RS14560	COG3681	Belongs to the UPF0597 family
GIS01_RS14570	COG0814	amino acid
GIS01_RS14590	COG1166	arginine decarboxylase activity
GIS01_RS14595	COG2195	Cleaves the N-terminal amino acid of tripeptides
GIS01_RS14610	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GIS01_RS14620	COG2353	YceI-like domain
GIS01_RS14625	COG0583	DNA-binding transcription factor activity
GIS01_RS14635	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GIS01_RS14640	COG0840	transmembrane signaling receptor activity
GIS01_RS14645	COG0302	gtp cyclohydrolase
GIS01_RS14650	COG0303	'Molybdopterin
GIS01_RS14655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GIS01_RS14670	COG2267	carboxylic ester hydrolase activity
GIS01_RS14675	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GIS01_RS14690	COG0314	molybdopterin synthase activity
GIS01_RS14695	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GIS01_RS14700	COG0315	cyclic pyranopterin monophosphate synthase activity
GIS01_RS14705	COG0521	Mo-molybdopterin cofactor biosynthetic process
GIS01_RS14710	COG3005	denitrification pathway
GIS01_RS14720	COG0348	domain, Protein
GIS01_RS14725	COG0437	4 iron, 4 sulfur cluster binding
GIS01_RS14730	COG0243	molybdopterin cofactor binding
GIS01_RS14740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GIS01_RS14745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GIS01_RS14750	COG3850	Histidine kinase
GIS01_RS14755	COG2197	response regulator
GIS01_RS14765	COG0784	Response regulator, receiver
GIS01_RS14765	COG2205	protein histidine kinase activity
GIS01_RS14785	COG0121	glutamine amidotransferase
GIS01_RS14790	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GIS01_RS14795	COG1960	acyl-CoA dehydrogenase activity
GIS01_RS14800	COG1473	amidohydrolase
GIS01_RS14810	COG2867	negative regulation of translational initiation
GIS01_RS14815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GIS01_RS15045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GIS01_RS15080	COG0270	DNA (cytosine-5-)-methyltransferase activity
GIS01_RS15115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GIS01_RS15145	COG2974	May be involved in recombination
GIS01_RS15215	COG2205	protein histidine kinase activity
GIS01_RS15215	COG0784	Response regulator, receiver
GIS01_RS15225	COG3383	formate dehydrogenase (NAD+) activity
GIS01_RS15235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GIS01_RS15245	COG1960	acyl-CoA dehydrogenase activity
GIS01_RS15250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_RS15260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GIS01_RS15265	COG1317	bacterial-type flagellum organization
GIS01_RS15355	COG0457	Tetratricopeptide repeat
GIS01_RS15425	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GIS01_RS15430	COG4790	Type iii secretion
GIS01_RS15435	COG4794	Type iii secretion
GIS01_RS15440	COG4791	protein targeting
GIS01_RS15445	COG4792	protein secretion
GIS01_RS15460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GIS01_RS15465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GIS01_RS15465	COG1263	PTS System
GIS01_RS15470	COG1609	Transcriptional regulator
GIS01_RS15480	COG4821	SIS domain
GIS01_RS15495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_RS15495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_RS15495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_RS15500	COG2271	Major facilitator Superfamily
GIS01_RS15505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_RS15515	COG1187	pseudouridine synthase activity
GIS01_RS15525	COG0482	sulfurtransferase activity
GIS01_RS15530	COG2915	High frequency lysogenization protein hflD homolog
GIS01_RS15535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GIS01_RS15540	COG2850	peptidyl-arginine hydroxylation
GIS01_RS15560	COG0625	glutathione transferase activity
GIS01_RS15565	COG0259	pyridoxamine-phosphate oxidase activity
GIS01_RS15605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GIS01_RS15605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GIS01_RS15610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GIS01_RS15620	COG2853	Lipoprotein
GIS01_RS15630	COG4235	cytochrome complex assembly
GIS01_RS15630	COG3088	subunit of a heme lyase
GIS01_RS15635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GIS01_RS15640	COG1138	Cytochrome C-type biogenesis protein
GIS01_RS15645	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GIS01_RS15650	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GIS01_RS15655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GIS01_RS15660	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GIS01_RS15675	COG0835	chemotaxis
GIS01_RS15685	COG1192	Involved in chromosome partitioning
GIS01_RS15690	COG1360	Flagellar Motor Protein
GIS01_RS15695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GIS01_RS15700	COG2201	protein-glutamate methylesterase activity
GIS01_RS15705	COG2198	Histidine kinase
GIS01_RS15705	COG0643	Histidine kinase
GIS01_RS15710	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GIS01_RS15725	COG0455	bacterial-type flagellum organization
GIS01_RS15735	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GIS01_RS15745	COG1684	flagellar biosynthetic protein fliR
GIS01_RS15750	COG1987	bacterial-type flagellum assembly
GIS01_RS15800	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GIS01_RS15810	COG1677	Flagellar hook-basal body complex protein FliE
GIS01_RS15830	COG0469	pyruvate kinase activity
GIS01_RS15835	COG1737	Transcriptional regulator
GIS01_RS15840	COG0837	glucose binding
GIS01_RS15870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_RS15890	COG0281	malic enzyme
GIS01_RS15910	COG0437	4 iron, 4 sulfur cluster binding
GIS01_RS15915	COG3383	formate dehydrogenase (NAD+) activity
GIS01_RS15915	COG3383	formate dehydrogenase (NAD+) activity
GIS01_RS15955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GIS01_RS15965	COG3852	Histidine kinase
GIS01_RS15970	COG2204	response regulator
GIS01_RS15980	COG4662	Binding-protein-dependent transport system inner membrane component
GIS01_RS15990	COG0746	molybdenum cofactor guanylyltransferase activity
GIS01_RS15995	COG0303	'Molybdopterin
GIS01_RS16000	COG1289	transmembrane transporter activity
GIS01_RS16005	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_RS16035	COG3220	belongs to the UPF0276 family
GIS01_RS16065	COG2205	protein histidine kinase activity
GIS01_RS16065	COG0784	Response regulator, receiver
GIS01_RS16080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GIS01_RS16085	COG0444	Belongs to the ABC transporter superfamily
GIS01_RS16090	COG4608	Belongs to the ABC transporter superfamily
GIS01_RS16100	COG2971	BadF BadG BcrA BcrD
GIS01_RS16110	COG0840	transmembrane signaling receptor activity
GIS01_RS16120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GIS01_RS16125	COG3724	N-succinylarginine dihydrolase activity
GIS01_RS16155	COG2197	response regulator
GIS01_RS16185	COG2199	diguanylate cyclase activity
GIS01_RS16185	COG2200	EAL domain
GIS01_RS16185	COG2203	Gaf domain
GIS01_RS16195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GIS01_RS16205	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GIS01_RS16210	COG3706	GGDEF domain
GIS01_RS16215	COG2211	Major facilitator Superfamily
GIS01_RS16220	COG0616	signal peptide processing
GIS01_RS16225	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_RS16230	COG0583	DNA-binding transcription factor activity
GIS01_RS16240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GIS01_RS16260	COG1881	PFAM PEBP family protein
GIS01_RS16280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GIS01_RS16295	COG1301	dicarboxylic acid transport
GIS01_RS16300	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GIS01_RS16305	COG2912	Transglutaminase-like superfamily
GIS01_RS16315	COG2890	protein-(glutamine-N5) methyltransferase activity
GIS01_RS16320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GIS01_RS16325	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GIS01_RS16330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GIS01_RS16335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GIS01_RS16345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GIS01_RS16350	COG0737	Belongs to the 5'-nucleotidase family
GIS01_RS16355	COG0193	aminoacyl-tRNA hydrolase activity
GIS01_RS16360	COG0012	GTP binding
GIS01_RS16405	COG0490	domain, Protein
GIS01_RS16405	COG0471	metal ion transport
GIS01_RS16415	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GIS01_RS16435	COG0366	Alpha amylase catalytic
GIS01_RS16440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_RS16440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GIS01_RS16440	COG1013	pyruvate-flavodoxin oxidoreductase activity
GIS01_RS16440	COG0674	pyruvate-flavodoxin oxidoreductase activity
GIS01_RS16450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GIS01_RS16465	COG1012	belongs to the aldehyde dehydrogenase family
GIS01_RS16475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GIS01_RS16480	COG0512	Glutamine amidotransferase of anthranilate synthase
GIS01_RS16490	COG0180	Tryptophanyl-tRNA synthetase
GIS01_RS16500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GIS01_RS16505	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GIS01_RS16515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GIS01_RS16520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GIS01_RS16550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GIS01_RS16555	COG0583	DNA-binding transcription factor activity
GIS01_RS16575	COG0583	DNA-binding transcription factor activity
GIS01_RS16585	COG0739	heme binding
GIS01_RS16595	COG3264	Mechanosensitive ion channel
GIS01_RS16595	COG1511	domain protein
GIS01_RS16600	COG0584	glycerophosphoryl diester phosphodiesterase
GIS01_RS16610	COG1053	succinate dehydrogenase
GIS01_RS16615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GIS01_RS16620	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GIS01_RS16625	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GIS01_RS16630	COG3366	ferrous iron transmembrane transporter activity
GIS01_RS16635	COG0700	Nucleoside recognition
GIS01_RS16640	COG2195	Cleaves the N-terminal amino acid of tripeptides
GIS01_RS16650	COG3214	Protein conserved in bacteria
GIS01_RS16665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_RS16680	COG1022	Amp-dependent synthetase and ligase
GIS01_RS16690	COG4221	oxidoreductase activity
GIS01_RS16700	COG0745	RESPONSE REGULATOR receiver
GIS01_RS16705	COG0642	Histidine kinase
GIS01_RS16725	COG0516	GMP reductase activity
GIS01_RS16735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GIS01_RS16745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GIS01_RS16770	COG0583	DNA-binding transcription factor activity
GIS01_RS16775	COG3706	GGDEF domain
GIS01_RS16785	COG1335	isochorismatase
GIS01_RS16790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GIS01_RS16795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GIS01_RS16800	COG1702	phosphate starvation-inducible protein PhoH
GIS01_RS16805	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GIS01_RS16810	COG4535	Mg2 and Co2 transporter CorC
GIS01_RS16815	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GIS01_RS16820	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GIS01_RS16830	COG0789	Transcriptional regulator
GIS01_RS16845	COG1970	mechanosensitive ion channel activity
GIS01_RS16850	COG4974	Belongs to the 'phage' integrase family
GIS01_RS16855	COG0716	FMN binding
GIS01_RS16865	COG0312	modulator of DNA gyrase
GIS01_RS16870	COG2888	peptidyl-tyrosine sulfation
GIS01_RS16875	COG0495	leucyl-tRNA aminoacylation
GIS01_RS16890	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GIS01_RS16895	COG0799	negative regulation of ribosome biogenesis
GIS01_RS16900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GIS01_RS16905	COG0768	penicillin binding
GIS01_RS16910	COG0772	Belongs to the SEDS family
GIS01_RS16915	COG2951	lytic endotransglycosylase activity
GIS01_RS16920	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GIS01_RS16925	COG1686	Belongs to the peptidase S11 family
GIS01_RS16930	COG2921	Belongs to the UPF0250 family
GIS01_RS16935	COG0321	lipoyl(octanoyl) transferase activity
GIS01_RS16940	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GIS01_RS16960	COG3139	Protein of unknown function (DUF1315)
GIS01_RS16965	COG0252	asparaginase activity
GIS01_RS16970	COG0786	glutamate:sodium symporter activity
GIS01_RS16985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GIS01_RS16990	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GIS01_RS16995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GIS01_RS17010	COG3610	response to peptide
GIS01_RS17015	COG2966	Psort location CytoplasmicMembrane, score
GIS01_RS17025	COG0521	Mo-molybdopterin cofactor biosynthetic process
GIS01_RS17040	COG2897	thiosulfate sulfurtransferase activity
GIS01_RS17045	COG2066	Belongs to the glutaminase family
GIS01_RS17050	COG3171	Protein conserved in bacteria
GIS01_RS17055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GIS01_RS17060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GIS01_RS17065	COG2200	EAL domain
GIS01_RS17070	COG1090	epimerase
GIS01_RS17075	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GIS01_RS17080	COG4181	ATPase activity
GIS01_RS17085	COG2755	lipolytic protein G-D-S-L family
GIS01_RS17090	COG0835	chemotaxis
GIS01_RS17090	COG0784	Response regulator, receiver
GIS01_RS17140	COG3397	chitin binding
GIS01_RS17160	COG5002	protein histidine kinase activity
GIS01_RS17160	COG0784	Response regulator, receiver
GIS01_RS17160	COG2205	protein histidine kinase activity
GIS01_RS17170	COG3655	Transcriptional regulator
GIS01_RS17180	COG2814	Major facilitator Superfamily
GIS01_RS17205	COG0748	coenzyme F420 binding
GIS01_RS17210	COG3721	Heme iron utilization protein
GIS01_RS17220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GIS01_RS17240	COG0432	Pfam Uncharacterised protein family UPF0047
GIS01_RS17245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GIS01_RS17250	COG0305	Participates in initiation and elongation during chromosome replication
GIS01_RS17265	COG1047	Peptidyl-prolyl cis-trans
GIS01_RS17270	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GIS01_RS17280	COG0835	chemotaxis
GIS01_RS17280	COG0784	Response regulator, receiver
GIS01_RS17285	COG0429	hydrolase of the alpha beta-hydrolase fold
GIS01_RS17290	COG5001	Diguanylate cyclase
GIS01_RS17290	COG3706	GGDEF domain
GIS01_RS17290	COG4251	negative regulation of phosphorylation
GIS01_RS17290	COG2203	Gaf domain
GIS01_RS17295	COG3089	Belongs to the UPF0270 family
GIS01_RS17300	COG3954	Phosphoribulokinase
GIS01_RS17315	COG1765	OsmC-like protein
GIS01_RS17320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GIS01_RS17355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIS01_RS17360	COG2313	pseudouridylate synthase activity
GIS01_RS17390	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GIS01_RS17410	COG0569	domain protein
GIS01_RS17410	COG2985	domain, Protein
GIS01_RS17415	COG1272	protein, Hemolysin III
GIS01_RS17420	COG0076	glutamate decarboxylase activity
GIS01_RS17425	COG2917	probably involved in intracellular septation
GIS01_RS17430	COG2350	Protein conserved in bacteria
GIS01_RS17440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GIS01_RS17445	COG1381	Involved in DNA repair and RecF pathway recombination
GIS01_RS17460	COG0681	Belongs to the peptidase S26 family
GIS01_RS17465	COG0481	GTPase activity
GIS01_RS17475	COG3026	antisigma factor binding
GIS01_RS17480	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GIS01_RS17485	COG1595	DNA-templated transcription, initiation
GIS01_RS17490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GIS01_RS17500	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GIS01_RS17505	COG0354	folic acid binding
GIS01_RS17530	COG4232	protein-disulfide reductase activity
GIS01_RS17550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_RS17555	COG0191	fructose-bisphosphate aldolase activity
GIS01_RS17560	COG0126	phosphoglycerate kinase activity
GIS01_RS17565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GIS01_RS17570	COG1940	carbohydrate kinase activity
GIS01_RS17575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GIS01_RS17580	COG2816	NAD+ diphosphatase activity
GIS01_RS17590	COG4991	sh3 domain protein
GIS01_RS17595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GIS01_RS17610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GIS01_RS17635	COG4191	Histidine kinase
GIS01_RS17700	COG1858	cytochrome C peroxidase
GIS01_RS17705	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GIS01_RS17715	COG2203	Gaf domain
GIS01_RS17715	COG2199	diguanylate cyclase activity
GIS01_RS17720	COG0513	Belongs to the DEAD box helicase family
GIS01_RS17750	COG0154	amidase activity
GIS01_RS17755	COG2957	Belongs to the agmatine deiminase family
GIS01_RS17775	COG1902	pentaerythritol trinitrate reductase activity
GIS01_RS17790	COG1238	metal cluster binding
GIS01_RS17795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GIS01_RS17800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GIS01_RS17805	COG0585	pseudouridine synthase activity
GIS01_RS17815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GIS01_RS17820	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GIS01_RS17825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GIS01_RS17835	COG1376	ErfK ybiS ycfS ynhG family protein
GIS01_RS17840	COG0668	transmembrane transport
GIS01_RS17850	COG2731	YhcH YjgK YiaL family protein
GIS01_RS17860	COG1794	racemase activity, acting on amino acids and derivatives
GIS01_RS17875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GIS01_RS17895	COG0488	(ABC) transporter
GIS01_RS17905	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GIS01_RS17950	COG0148	phosphopyruvate hydratase activity
GIS01_RS17955	COG0504	CTP synthase activity
GIS01_RS17960	COG3956	TIGRFAM MazG family protein
GIS01_RS17965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GIS01_RS17970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GIS01_RS17980	COG4807	Protein conserved in bacteria
GIS01_RS17985	COG3023	N-Acetylmuramoyl-L-alanine amidase
GIS01_RS17990	COG0783	Belongs to the Dps family
GIS01_RS17995	COG1151	hydroxylamine reductase activity
GIS01_RS18000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GIS01_RS18005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GIS01_RS18010	COG0671	phosphoesterase, PA-phosphatase related
GIS01_RS18015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GIS01_RS18020	COG0163	prenyltransferase activity
GIS01_RS18035	COG1131	(ABC) transporter
GIS01_RS18040	COG0842	Transport permease protein
GIS01_RS18045	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GIS01_RS18050	COG1924	4 iron, 4 sulfur cluster binding
GIS01_RS18075	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GIS01_RS18080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GIS01_RS18085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GIS01_RS18095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GIS01_RS18100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GIS01_RS18105	COG1489	DNA binding
GIS01_RS18115	COG1643	Atp-dependent helicase
GIS01_RS18120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GIS01_RS18125	COG0346	lactoylglutathione lyase activity
GIS01_RS18130	COG2076	Multidrug Resistance protein
GIS01_RS18135	COG2076	Multidrug Resistance protein
GIS01_RS18145	COG0784	Response regulator, receiver
GIS01_RS18145	COG3437	response regulator, receiver
GIS01_RS18150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GIS01_RS18165	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GIS01_RS18200	COG0840	transmembrane signaling receptor activity
GIS01_RS18215	COG0529	Catalyzes the synthesis of activated sulfate
GIS01_RS18220	COG3273	potassium ion transport
GIS01_RS18220	COG0471	metal ion transport
GIS01_RS18225	COG2895	sulfate adenylyltransferase (ATP) activity
GIS01_RS18230	COG0175	sulfate reduction
GIS01_RS18235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GIS01_RS18235	COG1648	precorrin-2 dehydrogenase activity
GIS01_RS18240	COG0330	HflC and HflK could
GIS01_RS18245	COG1585	Membrane protein implicated in regulation of membrane protease activity
GIS01_RS18250	COG0840	transmembrane signaling receptor activity
GIS01_RS18255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GIS01_RS18260	COG0676	glucose-6-phosphate 1-epimerase activity
GIS01_RS18265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GIS01_RS18270	COG1640	4-alpha-glucanotransferase
GIS01_RS18275	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GIS01_RS18310	COG1522	sequence-specific DNA binding
GIS01_RS18325	COG0561	phosphatase activity
GIS01_RS18340	COG0733	neurotransmitter:sodium symporter activity
GIS01_RS18350	COG0733	neurotransmitter:sodium symporter activity
GIS01_RS18375	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GIS01_RS18380	COG2885	chlorophyll binding
GIS01_RS18385	COG0823	Involved in the tonB-independent uptake of proteins
GIS01_RS18400	COG0811	peptide transport
GIS01_RS18405	COG0824	Thioesterase
GIS01_RS18410	COG3790	cyd operon protein YbgE
GIS01_RS18415	COG4890	Cyd operon protein YbgT
GIS01_RS18420	COG1294	oxidase, subunit
GIS01_RS18430	COG2255	four-way junction helicase activity
GIS01_RS18435	COG0632	four-way junction helicase activity
GIS01_RS18440	COG0840	transmembrane signaling receptor activity
GIS01_RS18450	COG2771	luxR family
GIS01_RS18455	COG3916	Acyl-homoserine-lactone synthase
GIS01_RS18465	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GIS01_RS18470	COG2203	Gaf domain
GIS01_RS18470	COG4251	negative regulation of phosphorylation
GIS01_RS18470	COG5001	Diguanylate cyclase
GIS01_RS18470	COG3706	GGDEF domain
GIS01_RS18480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GIS01_RS18490	COG2995	paraquat-inducible protein a
GIS01_RS18495	COG3008	intermembrane lipid transfer
GIS01_RS18495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GIS01_RS18505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GIS01_RS18510	COG0442	prolyl-tRNA aminoacylation
GIS01_RS18515	COG4221	oxidoreductase activity
GIS01_RS18530	COG1024	Enoyl-CoA hydratase
GIS01_RS18540	COG0110	maltose O-acetyltransferase activity
GIS01_RS18550	COG4166	transmembrane transport
GIS01_RS18560	COG0840	transmembrane signaling receptor activity
GIS01_RS18570	COG2918	glutathione biosynthetic process
GIS01_RS18575	COG0612	Peptidase, M16
GIS01_RS18580	COG1238	metal cluster binding
GIS01_RS18585	COG1064	alcohol dehydrogenase
GIS01_RS18610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GIS01_RS18615	COG0359	binds to the 23S rRNA
GIS01_RS18620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GIS01_RS18625	COG0360	Binds together with S18 to 16S ribosomal RNA
GIS01_RS18630	COG1914	H( )-stimulated, divalent metal cation uptake system
GIS01_RS18635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GIS01_RS18645	COG0776	regulation of translation
GIS01_RS18660	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GIS01_RS18675	COG0560	Phosphoserine phosphatase
GIS01_RS18685	COG0813	purine-nucleoside phosphorylase activity
GIS01_RS18690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GIS01_RS18695	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GIS01_RS18700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GIS01_RS18710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GIS01_RS18715	COG0084	hydrolase, TatD family'
GIS01_RS18720	COG4968	Prepilin-type N-terminal cleavage methylation domain
GIS01_RS18730	COG1854	S-ribosylhomocysteine lyase activity
GIS01_RS18745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GIS01_RS18745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GIS01_RS18785	COG4968	Prepilin-type N-terminal cleavage methylation domain
GIS01_RS18790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GIS01_RS18795	COG1047	Peptidyl-prolyl cis-trans
GIS01_RS18800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GIS01_RS18805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GIS01_RS18810	COG0196	riboflavin kinase activity
GIS01_RS18815	COG0728	peptidoglycan biosynthetic process
GIS01_RS18820	COG0268	Binds directly to 16S ribosomal RNA
GIS01_RS18825	COG0640	Transcriptional regulator
GIS01_RS18830	COG0583	DNA-binding transcription factor activity
GIS01_RS18840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GIS01_RS18845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GIS01_RS18850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GIS01_RS18855	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GIS01_RS18860	COG1051	belongs to the nudix hydrolase family
GIS01_RS18865	COG3066	DNA modification
GIS01_RS18875	COG0335	large ribosomal subunit rRNA binding
GIS01_RS18880	COG0336	Belongs to the RNA methyltransferase TrmD family
GIS01_RS18885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GIS01_RS18890	COG0228	four-way junction DNA binding
GIS01_RS18895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GIS01_RS18900	COG4137	Cytochrome C assembly protein
GIS01_RS18905	COG4536	flavin adenine dinucleotide binding
GIS01_RS18915	COG1017	nitric oxide dioxygenase activity
GIS01_RS18915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GIS01_RS18920	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GIS01_RS18925	COG0039	L-malate dehydrogenase activity
GIS01_RS18930	COG4160	amino acid transport
GIS01_RS18935	COG4215	(ABC) transporter
GIS01_RS18940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_RS18945	COG1126	abc transporter atp-binding protein
GIS01_RS18950	COG1438	arginine binding
GIS01_RS18965	COG1872	DUF167
GIS01_RS18970	COG0762	integral membrane protein
GIS01_RS18975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GIS01_RS18980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GIS01_RS18995	COG3022	response to hydroperoxide
GIS01_RS19015	COG0347	Belongs to the P(II) protein family
GIS01_RS19020	COG1840	ABC-type Fe3 transport system, periplasmic component
GIS01_RS19030	COG3842	ATPase activity
GIS01_RS19035	COG2837	iron assimilation
GIS01_RS19040	COG3385	transposase activity
GIS01_RS19045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GIS01_RS19050	COG0583	DNA-binding transcription factor activity
GIS01_RS19065	COG1929	Belongs to the glycerate kinase type-1 family
GIS01_RS19070	COG2610	gluconate transmembrane transporter activity
GIS01_RS19075	COG3835	regulator
GIS01_RS19080	COG3112	Uncharacterised protein family (UPF0231)
GIS01_RS19100	COG3568	Endonuclease Exonuclease Phosphatase
GIS01_RS19110	COG0513	Belongs to the DEAD box helicase family
GIS01_RS19150	COG1448	Aminotransferase
GIS01_RS19165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GIS01_RS19170	COG1328	CTP reductase activity
GIS01_RS19185	COG0543	2 iron, 2 sulfur cluster binding
GIS01_RS19185	COG0633	Ferredoxin
GIS01_RS19200	COG0840	transmembrane signaling receptor activity
GIS01_RS19205	COG3397	chitin binding
GIS01_RS19210	COG0583	DNA-binding transcription factor activity
GIS01_RS19215	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GIS01_RS19220	COG4208	sulfate ABC transporter
GIS01_RS19225	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GIS01_RS19235	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GIS01_RS19240	COG3174	membrane
GIS01_RS19245	COG0110	maltose O-acetyltransferase activity
GIS01_RS19260	COG1011	Hydrolase
GIS01_RS19265	COG0494	nUDIX hydrolase
GIS01_RS19270	COG1218	3'(2'),5'-bisphosphate nucleotidase
GIS01_RS19275	COG0814	amino acid
GIS01_RS19280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIS01_RS19295	COG0626	cystathionine gamma-synthase activity
GIS01_RS19300	COG0527	aspartate kinase activity
GIS01_RS19300	COG0460	homoserine dehydrogenase
GIS01_RS19305	COG0306	phosphate transporter
GIS01_RS19310	COG1392	Phosphate transport regulator
GIS01_RS19320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GIS01_RS19325	COG2813	Specifically methylates the guanine in position
GIS01_RS19330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GIS01_RS19335	COG0297	glycogen (starch) synthase activity
GIS01_RS19375	COG1757	Na H antiporter
GIS01_RS19380	COG0316	Belongs to the HesB IscA family
GIS01_RS19390	COG0038	chloride channel
GIS01_RS19395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GIS01_RS19445	COG1396	sequence-specific DNA binding
GIS01_RS19450	COG3135	benzoate transporter
GIS01_RS19475	COG0840	transmembrane signaling receptor activity
GIS01_RS19480	COG3047	cAMP biosynthetic process
GIS01_RS19485	COG3706	GGDEF domain
GIS01_RS19490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GIS01_RS19510	COG1462	curli production assembly transport component CsgG
GIS01_RS19525	COG2197	response regulator
GIS01_RS19565	COG5499	transcription regulator containing HTH domain
GIS01_RS19620	COG1278	Cold shock
GIS01_RS19625	COG2252	PERMEase
GIS01_RS19630	COG2376	Dihydroxyacetone kinase
GIS01_RS19635	COG1461	Dihydroxyacetone kinase
GIS01_RS19640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_RS19640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GIS01_RS19640	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GIS01_RS19650	COG3284	Transcriptional regulator
GIS01_RS19660	COG0628	permease
GIS01_RS19665	COG0494	nUDIX hydrolase
GIS01_RS19680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GIS01_RS19710	COG3133	Outer membrane lipoprotein
GIS01_RS19715	COG0004	ammonium transporteR
GIS01_RS19720	COG3706	GGDEF domain
GIS01_RS19730	COG3932	Exopolysaccharide synthesis, ExoD
GIS01_RS19735	COG0814	amino acid
GIS01_RS19740	COG3706	GGDEF domain
GIS01_RS19750	COG0110	maltose O-acetyltransferase activity
GIS01_RS19765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GIS01_RS19770	COG2022	thiamine diphosphate biosynthetic process
GIS01_RS19780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GIS01_RS19785	COG0352	thiamine-phosphate diphosphorylase activity
GIS01_RS19790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GIS01_RS19810	COG0745	RESPONSE REGULATOR receiver
GIS01_RS19820	COG0189	ligase activity
GIS01_RS19865	COG0477	Major facilitator Superfamily
GIS01_RS19880	COG0312	modulator of DNA gyrase
GIS01_RS19885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GIS01_RS19895	COG3164	Protein of unknown function
GIS01_RS19900	COG1530	ribonuclease E activity
GIS01_RS19905	COG0424	maF-like protein
GIS01_RS19910	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GIS01_RS19915	COG1792	Involved in formation and maintenance of cell shape
GIS01_RS19920	COG1077	Cell shape determining protein MreB Mrl
GIS01_RS19945	COG4968	Prepilin-type N-terminal cleavage methylation domain
GIS01_RS19950	COG4969	Belongs to the N-Me-Phe pilin family
GIS01_RS19965	COG1459	type II secretion system
GIS01_RS19970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GIS01_RS20015	COG2199	diguanylate cyclase activity
GIS01_RS20015	COG2200	EAL domain
GIS01_RS20020	COG2200	EAL domain
GIS01_RS20025	COG0387	Pfam Sodium calcium exchanger
GIS01_RS20030	COG2986	histidine ammonia-lyase
GIS01_RS20035	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GIS01_RS20040	COG0010	Belongs to the arginase family
GIS01_RS20045	COG1228	amidohydrolase
GIS01_RS20050	COG2188	Transcriptional regulator
GIS01_RS20055	COG0288	reversible hydration of carbon dioxide
GIS01_RS20065	COG2177	Part of the ABC transporter FtsEX involved in
GIS01_RS20070	COG2884	Cell division ATP-binding protein ftsE
GIS01_RS20075	COG0552	protein localization to endoplasmic reticulum
GIS01_RS20080	COG0742	ribosomal rna small subunit methyltransferase
GIS01_RS20105	COG2249	NAD(P)H dehydrogenase (quinone) activity
GIS01_RS20110	COG0583	DNA-binding transcription factor activity
GIS01_RS20115	COG4221	oxidoreductase activity
GIS01_RS20130	COG1770	oligopeptidase
GIS01_RS20145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GIS01_RS20150	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GIS01_RS20160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GIS01_RS20170	COG2095	MarC family integral membrane protein
GIS01_RS20180	COG1301	dicarboxylic acid transport
GIS01_RS20205	COG3714	YhhN family
GIS01_RS20260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GIS01_RS20265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GIS01_RS20270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GIS01_RS20275	COG0049	tRNA binding
GIS01_RS20280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GIS01_RS20285	COG2168	tRNA wobble position uridine thiolation
GIS01_RS20290	COG2923	Belongs to the DsrF TusC family
GIS01_RS20295	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GIS01_RS20305	COG2964	Protein conserved in bacteria
GIS01_RS20310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GIS01_RS20315	COG0085	RNA polymerase activity
GIS01_RS20320	COG0222	ribosome binding
GIS01_RS20325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GIS01_RS20330	COG0081	regulation of translation
GIS01_RS20335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GIS01_RS20340	COG0250	Participates in transcription elongation, termination and antitermination
GIS01_RS20345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GIS01_RS20355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GIS01_RS20380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GIS01_RS20385	COG0569	domain protein
GIS01_RS20390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GIS01_RS20420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_RS20420	COG4191	Histidine kinase
GIS01_RS20425	COG3005	denitrification pathway
GIS01_RS20430	COG0243	molybdopterin cofactor binding
GIS01_RS20440	COG2205	protein histidine kinase activity
GIS01_RS20445	COG0745	RESPONSE REGULATOR receiver
GIS01_RS20480	COG2204	response regulator
GIS01_RS20490	COG2205	protein histidine kinase activity
GIS01_RS20505	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_RS20510	COG0517	IMP dehydrogenase activity
GIS01_RS20510	COG0516	GMP reductase activity
GIS01_RS20515	COG5413	integral membrane protein
GIS01_RS20525	COG1522	sequence-specific DNA binding
GIS01_RS20530	COG2502	aspartate--ammonia ligase
GIS01_RS20535	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GIS01_RS20540	COG0542	response to heat
GIS01_RS20550	COG0564	pseudouridine synthase activity
GIS01_RS20555	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GIS01_RS20560	COG0446	pyridine nucleotide-disulphide oxidoreductase
GIS01_RS20570	COG3681	Belongs to the UPF0597 family
GIS01_RS20575	COG2964	Protein conserved in bacteria
GIS01_RS20585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GIS01_RS20590	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GIS01_RS20595	COG1979	alcohol dehydrogenase
GIS01_RS20600	COG2207	Transcriptional regulator
GIS01_RS20605	COG3040	lipid binding
GIS01_RS20620	COG0583	DNA-binding transcription factor activity
GIS01_RS20640	COG0540	Belongs to the ATCase OTCase family
GIS01_RS20645	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GIS01_RS20650	COG1438	arginine binding
GIS01_RS20655	COG1288	antiporter activity
GIS01_RS20660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GIS01_RS20685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GIS01_RS20695	COG3078	GTPase activator activity
GIS01_RS20705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GIS01_RS20715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GIS01_RS20720	COG0408	coproporphyrinogen oxidase activity
GIS01_RS20725	COG0009	L-threonylcarbamoyladenylate synthase
GIS01_RS20735	COG0551	DNA topoisomerase type I activity
GIS01_RS20740	COG2922	Belongs to the Smg family
GIS01_RS20745	COG0758	DNA mediated transformation
GIS01_RS20750	COG1652	LysM domain
GIS01_RS20755	COG0242	peptide deformylase activity
GIS01_RS20760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GIS01_RS20765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GIS01_RS20765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GIS01_RS20770	COG0569	domain protein
GIS01_RS20775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GIS01_RS20785	COG0174	glutamine synthetase
GIS01_RS20795	COG3852	Histidine kinase
GIS01_RS20800	COG2204	response regulator
GIS01_RS20805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GIS01_RS20815	COG1322	Protein conserved in bacteria
GIS01_RS20835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIS01_RS20840	COG0583	DNA-binding transcription factor activity
GIS01_RS20845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GIS01_RS20845	COG0519	Catalyzes the synthesis of GMP from XMP
GIS01_RS20860	COG1396	sequence-specific DNA binding
GIS01_RS20865	COG1012	belongs to the aldehyde dehydrogenase family
GIS01_RS20875	COG2962	Rard protein
GIS01_RS20885	COG2391	methyltransferase activity
GIS01_RS20900	COG0129	dihydroxy-acid dehydratase activity
GIS01_RS20905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GIS01_RS20910	COG3978	acetolactate synthase activity
GIS01_RS20925	COG0606	chelatase, subunit chli
GIS01_RS20930	COG0204	Acyl-transferase
GIS01_RS20935	COG0204	Acyl-transferase
GIS01_RS20940	COG1683	Conserved Protein
GIS01_RS20950	COG1335	isochorismatase
GIS01_RS20960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GIS01_RS20965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GIS01_RS20975	COG3084	Protein conserved in bacteria
GIS01_RS20980	COG5001	Diguanylate cyclase
GIS01_RS20980	COG4251	negative regulation of phosphorylation
GIS01_RS20980	COG3706	GGDEF domain
GIS01_RS20980	COG2203	Gaf domain
GIS01_RS20995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GIS01_RS21000	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GIS01_RS21005	COG1561	YicC-like family, N-terminal region
GIS01_RS21010	COG0583	DNA-binding transcription factor activity
GIS01_RS21035	COG0385	Bile acid
GIS01_RS21040	COG0531	amino acid
GIS01_RS21045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIS01_RS21050	COG0531	amino acid
GIS01_RS21055	COG2731	YhcH YjgK YiaL family protein
GIS01_RS21060	COG3250	beta-galactosidase activity
GIS01_RS21065	COG1609	Transcriptional regulator
GIS01_RS21100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GIS01_RS21105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GIS01_RS21105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GIS01_RS21110	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GIS01_RS21115	COG3074	FtsZ-dependent cytokinesis
GIS01_RS21125	COG1045	serine acetyltransferase
GIS01_RS21135	COG0745	RESPONSE REGULATOR receiver
GIS01_RS21140	COG2205	protein histidine kinase activity
GIS01_RS21145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GIS01_RS21150	COG0534	Mate efflux family protein
GIS01_RS21165	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GIS01_RS21170	COG2937	Belongs to the GPAT DAPAT family
GIS01_RS21175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GIS01_RS21180	COG3161	chorismate lyase activity
GIS01_RS21205	COG0604	alcohol dehydrogenase
GIS01_RS21210	COG1519	Transferase
GIS01_RS21215	COG0859	PFAM glycosyl transferase family 9
GIS01_RS21220	COG0463	Glycosyl transferase, family 2
GIS01_RS21225	COG0859	PFAM glycosyl transferase family 9
GIS01_RS21230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GIS01_RS21235	COG2990	Protein conserved in bacteria
GIS01_RS21240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GIS01_RS21250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GIS01_RS21255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GIS01_RS21260	COG2003	Belongs to the UPF0758 family
GIS01_RS21265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GIS01_RS21275	COG4974	Belongs to the 'phage' integrase family
GIS01_RS21315	COG2916	Histone family protein nucleoid-structuring protein H-NS
GIS01_RS21345	COG0756	dUTP diphosphatase activity
GIS01_RS21355	COG1309	transcriptional regulator
GIS01_RS21360	COG0668	transmembrane transport
GIS01_RS21365	COG0166	Belongs to the GPI family
GIS01_RS21370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GIS01_RS21375	COG0583	DNA-binding transcription factor activity
GIS01_RS21390	COG0045	succinate-CoA ligase (ADP-forming) activity
GIS01_RS21390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GIS01_RS21390	COG1042	CoA-binding domain protein
GIS01_RS21420	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GIS01_RS21425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GIS01_RS21430	COG1739	Uncharacterized protein family UPF0029
GIS01_RS21435	COG0006	proline dipeptidase activity
GIS01_RS21440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GIS01_RS21445	COG1024	Enoyl-CoA hydratase
GIS01_RS21445	COG1250	3-hydroxyacyl-CoA dehydrogenase
GIS01_RS21450	COG0183	Belongs to the thiolase family
GIS01_RS21455	COG0745	RESPONSE REGULATOR receiver
GIS01_RS21460	COG2205	protein histidine kinase activity
GIS01_RS21475	COG0425	Belongs to the sulfur carrier protein TusA family
GIS01_RS21480	COG0251	oxidation-reduction process
GIS01_RS21490	COG2885	chlorophyll binding
GIS01_RS21495	COG2818	Glycosylase
GIS01_RS21500	COG0752	glycyl-tRNA synthetase alpha subunit
GIS01_RS21505	COG0751	glycine-tRNA ligase activity
GIS01_RS21520	COG2199	diguanylate cyclase activity
GIS01_RS21520	COG2202	Pas domain
GIS01_RS21520	COG2200	EAL domain
GIS01_RS21545	COG1609	Transcriptional regulator
GIS01_RS21555	COG0559	Belongs to the binding-protein-dependent transport system permease family
GIS01_RS21575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GIS01_RS21590	COG2960	long-chain fatty acid transporting porin activity
GIS01_RS21595	COG5001	Diguanylate cyclase
GIS01_RS21605	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GIS01_RS21615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GIS01_RS21620	COG3118	belongs to the thioredoxin family
GIS01_RS21625	COG0513	Belongs to the DEAD box helicase family
GIS01_RS21630	COG0248	Ppx GppA phosphatase
GIS01_RS21640	COG0742	ribosomal rna small subunit methyltransferase
GIS01_RS21655	COG3469	chitinase activity
GIS01_RS21660	COG3397	chitin binding
GIS01_RS21670	COG0084	hydrolase, TatD family'
GIS01_RS21675	COG0805	protein transport
GIS01_RS21680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GIS01_RS21685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GIS01_RS21690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GIS01_RS21695	COG3165	ubiquinone biosynthetic process from chorismate
GIS01_RS21700	COG2226	methyltransferase
GIS01_RS21705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GIS01_RS21710	COG0402	S-adenosylhomocysteine deaminase activity
GIS01_RS21715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GIS01_RS21755	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GIS01_RS21760	COG0848	biopolymer transport protein
GIS01_RS21765	COG0811	peptide transport
GIS01_RS21770	COG0811	peptide transport
GIS01_RS21780	COG2771	luxR family
GIS01_RS21785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GIS01_RS21790	COG1349	DNA-binding transcription factor activity
GIS01_RS21795	COG0745	RESPONSE REGULATOR receiver
GIS01_RS21800	COG2205	protein histidine kinase activity
GIS01_RS21815	COG4452	Inner membrane protein CreD
GIS01_RS21820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GIS01_RS21825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GIS01_RS21830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GIS01_RS21835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GIS01_RS21840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GIS01_RS21845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GIS01_RS21850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GIS01_RS21860	COG0356	it plays a direct role in the translocation of protons across the membrane
GIS01_RS21870	COG1475	DNA binding
GIS01_RS21875	COG1192	Involved in chromosome partitioning
GIS01_RS21880	COG0357	Ribosomal RNA small subunit methyltransferase G
GIS01_RS21885	COG0445	tRNA wobble uridine modification
GIS01_RS21890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GIS01_RS21900	COG4615	Cyclic peptide transporter
GIS01_RS21905	COG1120	ATPase activity
GIS01_RS21910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GIS01_RS21920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GIS01_RS21925	COG0706	membrane insertase activity
GIS01_RS21930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GIS01_RS21935	COG0594	ribonuclease P activity
GIS01_RS21940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GIS01_RS21965	COG2026	Addiction module toxin, RelE StbE family
GIS01_RS22005	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
GIS01_RS22060	COG1192	Involved in chromosome partitioning
GIS01_RS22080	COG1609	Transcriptional regulator