locus-tag	class	description
HXV88_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HXV88_RS00010	COG0592	DNA-directed DNA polymerase activity
HXV88_RS00020	COG0187	DNA topoisomerase II activity
HXV88_RS00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HXV88_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
HXV88_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
HXV88_RS00045	COG3977	Valine--pyruvate aminotransferase
HXV88_RS00060	COG2814	Major facilitator Superfamily
HXV88_RS00065	COG0745	RESPONSE REGULATOR receiver
HXV88_RS00070	COG2205	protein histidine kinase activity
HXV88_RS00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HXV88_RS00095	COG4191	Histidine kinase
HXV88_RS00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_RS00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_RS00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_RS00110	COG1309	transcriptional regulator
HXV88_RS00140	COG0561	phosphatase activity
HXV88_RS00145	COG2267	carboxylic ester hydrolase activity
HXV88_RS00155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HXV88_RS00160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HXV88_RS00165	COG1758	RNA polymerase activity
HXV88_RS00170	COG0194	GDP metabolic process
HXV88_RS00175	COG0859	PFAM glycosyl transferase family 9
HXV88_RS00180	COG3642	lipopolysaccharide core region biosynthetic process
HXV88_RS00220	COG0589	response to stress
HXV88_RS00225	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HXV88_RS00230	COG1528	Iron-storage protein
HXV88_RS00235	COG2081	HI0933 family
HXV88_RS00240	COG3275	phosphorelay sensor kinase activity
HXV88_RS00245	COG3279	Response regulator of the LytR AlgR family
HXV88_RS00250	COG2223	nitrite transmembrane transporter activity
HXV88_RS00255	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HXV88_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HXV88_RS00275	COG0583	DNA-binding transcription factor activity
HXV88_RS00315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HXV88_RS00320	COG2166	iron-sulfur cluster assembly
HXV88_RS00325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HXV88_RS00340	COG3245	cytochrome
HXV88_RS00345	COG1063	alcohol dehydrogenase
HXV88_RS00360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HXV88_RS00380	COG3306	glycosyltransferase involved in LPS biosynthesis
HXV88_RS00415	COG1280	lysine exporter protein (LysE YggA)
HXV88_RS00460	COG0210	DNA helicase
HXV88_RS00485	COG2239	Acts as a magnesium transporter
HXV88_RS00490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXV88_RS00490	COG1648	precorrin-2 dehydrogenase activity
HXV88_RS00495	COG2116	formate transmembrane transporter activity
HXV88_RS00505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HXV88_RS00510	COG0842	Transport permease protein
HXV88_RS00515	COG0842	Transport permease protein
HXV88_RS00520	COG1131	(ABC) transporter
HXV88_RS00525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_RS00535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HXV88_RS00540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HXV88_RS00550	COG0018	arginyl-trna synthetase
HXV88_RS00560	COG1595	DNA-templated transcription, initiation
HXV88_RS00570	COG1968	undecaprenyl-diphosphatase activity
HXV88_RS00575	COG2017	converts alpha-aldose to the beta-anomer
HXV88_RS00580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HXV88_RS00585	COG1085	galactose-1-phosphate uridylyltransferase
HXV88_RS00590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HXV88_RS00595	COG1609	Transcriptional regulator
HXV88_RS00600	COG3250	beta-galactosidase activity
HXV88_RS00610	COG1129	ABC transporter
HXV88_RS00615	COG4211	Belongs to the binding-protein-dependent transport system permease family
HXV88_RS00625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXV88_RS00640	COG0366	Alpha amylase catalytic
HXV88_RS00655	COG0443	Heat shock 70 kDa protein
HXV88_RS00660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HXV88_RS00665	COG3045	CreA protein
HXV88_RS00685	COG0174	glutamine synthetase
HXV88_RS00705	COG3842	ATPase activity
HXV88_RS00710	COG1176	ABC-type spermidine putrescine transport system, permease component I
HXV88_RS00715	COG1177	transmembrane transport
HXV88_RS00720	COG2258	MOSC domain
HXV88_RS00735	COG2050	protein possibly involved in aromatic compounds catabolism
HXV88_RS00740	COG0514	ATP-dependent DNA helicase (RecQ)
HXV88_RS00750	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HXV88_RS00760	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HXV88_RS00765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HXV88_RS00780	COG0254	rRNA binding
HXV88_RS00785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HXV88_RS00795	COG0702	epimerase
HXV88_RS00800	COG0814	amino acid
HXV88_RS00805	COG0281	malic enzyme
HXV88_RS00810	COG1295	ribonuclease BN
HXV88_RS00815	COG1490	D-aminoacyl-tRNA deacylase activity
HXV88_RS00820	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HXV88_RS00825	COG0456	acetyltransferase
HXV88_RS00835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HXV88_RS00840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HXV88_RS00845	COG2610	gluconate transmembrane transporter activity
HXV88_RS00850	COG3265	gluconokinase activity
HXV88_RS00860	COG0800	Aldolase
HXV88_RS00865	COG1609	Transcriptional regulator
HXV88_RS00875	COG4942	peptidase
HXV88_RS00880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HXV88_RS00885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXV88_RS00890	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HXV88_RS00895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HXV88_RS00900	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HXV88_RS00900	COG0316	Belongs to the HesB IscA family
HXV88_RS00905	COG1040	competence protein
HXV88_RS00910	COG0596	Alpha beta hydrolase
HXV88_RS00930	COG2183	response to ionizing radiation
HXV88_RS00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HXV88_RS00940	COG0745	RESPONSE REGULATOR receiver
HXV88_RS00955	COG0051	transcription antitermination factor activity, RNA binding
HXV88_RS00960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HXV88_RS00965	COG0088	Forms part of the polypeptide exit tunnel
HXV88_RS00970	COG0089	rRNA binding
HXV88_RS00975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HXV88_RS00980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HXV88_RS00985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HXV88_RS00990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HXV88_RS00995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HXV88_RS01000	COG0255	Belongs to the universal ribosomal protein uL29 family
HXV88_RS01005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HXV88_RS01010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HXV88_RS01015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HXV88_RS01020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HXV88_RS01025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HXV88_RS01030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HXV88_RS01035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HXV88_RS01040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HXV88_RS01045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HXV88_RS01050	COG1841	ribosomal large subunit assembly
HXV88_RS01055	COG0200	Binds to the 23S rRNA
HXV88_RS01060	COG0201	protein transport
HXV88_RS01065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HXV88_RS01070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HXV88_RS01075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HXV88_RS01080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HXV88_RS01085	COG0202	RNA polymerase activity
HXV88_RS01090	COG0203	ribosomal protein L17
HXV88_RS01120	COG4771	TonB-dependent receptor
HXV88_RS01125	COG3706	GGDEF domain
HXV88_RS01135	COG0745	RESPONSE REGULATOR receiver
HXV88_RS01145	COG0583	DNA-binding transcription factor activity
HXV88_RS01155	COG1741	Belongs to the pirin family
HXV88_RS01160	COG2259	Doxx family
HXV88_RS01165	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HXV88_RS01170	COG1074	ATP-dependent DNA helicase activity
HXV88_RS01175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HXV88_RS01190	COG3706	GGDEF domain
HXV88_RS01220	COG1175	transmembrane transport
HXV88_RS01230	COG3842	ATPase activity
HXV88_RS01260	COG2873	o-acetylhomoserine
HXV88_RS01270	COG4533	DNA binding
HXV88_RS01290	COG5380	lipid catabolic process
HXV88_RS01295	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HXV88_RS01300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HXV88_RS01325	COG0753	catalase activity
HXV88_RS01355	COG2927	DNA polymerase III (CHI subunit)
HXV88_RS01360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HXV88_RS01365	COG0795	lipopolysaccharide-transporting ATPase activity
HXV88_RS01370	COG0795	lipopolysaccharide-transporting ATPase activity
HXV88_RS01425	COG1494	fructose-1,6-bisphosphatase
HXV88_RS01440	COG2959	enzyme of heme biosynthesis
HXV88_RS01450	COG0181	hydroxymethylbilane synthase activity
HXV88_RS01455	COG3072	Adenylate cyclase
HXV88_RS01460	COG0400	carboxylic ester hydrolase activity
HXV88_RS01465	COG1965	Belongs to the frataxin family
HXV88_RS01475	COG0019	diaminopimelate decarboxylase activity
HXV88_RS01480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HXV88_RS01495	COG1011	Hydrolase
HXV88_RS01515	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HXV88_RS01520	COG3028	Belongs to the UPF0307 family
HXV88_RS01525	COG0312	modulator of DNA gyrase
HXV88_RS01530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HXV88_RS01535	COG5007	Belongs to the BolA IbaG family
HXV88_RS01545	COG2854	intermembrane phospholipid transfer
HXV88_RS01550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HXV88_RS01555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HXV88_RS01560	COG1127	ABC transporter
HXV88_RS01565	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HXV88_RS01565	COG0517	IMP dehydrogenase activity
HXV88_RS01570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HXV88_RS01575	COG3117	lipopolysaccharide transmembrane transporter activity
HXV88_RS01580	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HXV88_RS01585	COG1137	ATPase activity
HXV88_RS01600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_RS01605	COG1660	Displays ATPase and GTPase activities
HXV88_RS01610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_RS01615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_RS01615	COG3711	transcriptional antiterminator
HXV88_RS01630	COG3964	amidohydrolase
HXV88_RS01660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXV88_RS01665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXV88_RS01675	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HXV88_RS01680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HXV88_RS01685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HXV88_RS01690	COG0723	plastoquinol--plastocyanin reductase activity
HXV88_RS01695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HXV88_RS01700	COG2857	Cytochrome c1
HXV88_RS01705	COG0625	glutathione transferase activity
HXV88_RS01710	COG2969	positive regulation of protein catabolic process
HXV88_RS01720	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HXV88_RS01725	COG0792	nuclease activity
HXV88_RS01730	COG3107	peptidoglycan biosynthetic process
HXV88_RS01735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HXV88_RS01760	COG1987	bacterial-type flagellum assembly
HXV88_RS01785	COG1677	Flagellar hook-basal body complex protein FliE
HXV88_RS01795	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HXV88_RS01825	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HXV88_RS01830	COG1815	bacterial-type flagellum-dependent cell motility
HXV88_RS01845	COG1749	Flagellar hook protein flgE
HXV88_RS01850	COG4787	bacterial-type flagellum-dependent cell motility
HXV88_RS01855	COG4786	Flagellar basal body rod
HXV88_RS01860	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HXV88_RS01865	COG1706	bacterial-type flagellum-dependent cell motility
HXV88_RS01875	COG1256	bacterial-type flagellum assembly
HXV88_RS01875	COG4786	Flagellar basal body rod
HXV88_RS01880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXV88_RS01900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXV88_RS01905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HXV88_RS01930	COG1191	sigma factor activity
HXV88_RS01935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HXV88_RS01950	COG1388	LysM domain
HXV88_RS01950	COG0741	lytic transglycosylase activity
HXV88_RS01955	COG2001	Belongs to the MraZ family
HXV88_RS01960	COG0275	rRNA processing
HXV88_RS01965	COG3116	cell division
HXV88_RS01970	COG0768	penicillin binding
HXV88_RS01980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HXV88_RS01985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HXV88_RS01990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HXV88_RS01995	COG0772	Belongs to the SEDS family
HXV88_RS02000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HXV88_RS02005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HXV88_RS02015	COG0849	cell division
HXV88_RS02020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HXV88_RS02025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HXV88_RS02035	COG0653	protein targeting
HXV88_RS02040	COG0494	nUDIX hydrolase
HXV88_RS02045	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HXV88_RS02050	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HXV88_RS02060	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HXV88_RS02065	COG1459	type II secretion system
HXV88_RS02070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HXV88_RS02095	COG2186	Transcriptional regulator
HXV88_RS02100	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HXV88_RS02105	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXV88_RS02110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HXV88_RS02120	COG0840	transmembrane signaling receptor activity
HXV88_RS02125	COG1752	Esterase of the alpha-beta hydrolase superfamily
HXV88_RS02130	COG1049	propionate catabolic process, 2-methylcitrate cycle
HXV88_RS02135	COG2200	EAL domain
HXV88_RS02145	COG0523	cobalamin synthesis protein
HXV88_RS02150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_RS02165	COG0477	Major facilitator Superfamily
HXV88_RS02180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HXV88_RS02185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HXV88_RS02280	COG2314	TM2 domain
HXV88_RS02320	COG3121	Chaperone
HXV88_RS02325	COG3188	usher protein
HXV88_RS02335	COG2200	EAL domain
HXV88_RS02365	COG0165	Argininosuccinate lyase
HXV88_RS02370	COG0137	argininosuccinate synthase activity
HXV88_RS02380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HXV88_RS02385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HXV88_RS02395	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HXV88_RS02400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HXV88_RS02410	COG0583	DNA-binding transcription factor activity
HXV88_RS02415	COG1380	Effector of murein hydrolase LrgA
HXV88_RS02420	COG1346	cytolysis
HXV88_RS02430	COG4667	esterase of the alpha-beta hydrolase superfamily
HXV88_RS02435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HXV88_RS02440	COG1546	Belongs to the CinA family
HXV88_RS02445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HXV88_RS02455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HXV88_RS02460	COG0527	aspartate kinase activity
HXV88_RS02465	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HXV88_RS02500	COG1686	Belongs to the peptidase S11 family
HXV88_RS02505	COG0586	Pfam SNARE associated Golgi protein
HXV88_RS02510	COG1253	flavin adenine dinucleotide binding
HXV88_RS02515	COG0252	asparaginase activity
HXV88_RS02535	COG1263	PTS System
HXV88_RS02535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXV88_RS02540	COG0366	Alpha amylase catalytic
HXV88_RS02545	COG0110	maltose O-acetyltransferase activity
HXV88_RS02555	COG0564	pseudouridine synthase activity
HXV88_RS02560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HXV88_RS02590	COG2926	Belongs to the UPF0265 family
HXV88_RS02600	COG0561	phosphatase activity
HXV88_RS02610	COG1058	Belongs to the CinA family
HXV88_RS02610	COG1546	Belongs to the CinA family
HXV88_RS02620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HXV88_RS02630	COG1522	sequence-specific DNA binding
HXV88_RS02635	COG1368	sulfuric ester hydrolase activity
HXV88_RS02675	COG4221	oxidoreductase activity
HXV88_RS02690	COG1979	alcohol dehydrogenase
HXV88_RS02695	COG1803	Methylglyoxal synthase
HXV88_RS02715	COG1444	tRNA N-acetyltransferase activity
HXV88_RS02720	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_RS02725	COG0784	Response regulator, receiver
HXV88_RS02725	COG0835	chemotaxis
HXV88_RS02735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HXV88_RS02740	COG2949	membrane
HXV88_RS02745	COG3291	Pkd domain containing protein
HXV88_RS02750	COG0318	PFAM AMP-dependent synthetase and ligase
HXV88_RS02755	COG1441	menaquinone biosynthetic process
HXV88_RS02760	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HXV88_RS02765	COG0596	Alpha beta hydrolase
HXV88_RS02770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HXV88_RS02775	COG1169	isochorismate synthase
HXV88_RS02780	COG1575	Belongs to the MenA family. Type 1 subfamily
HXV88_RS02805	COG0513	Belongs to the DEAD box helicase family
HXV88_RS02810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HXV88_RS02815	COG1988	membrane-bound metal-dependent
HXV88_RS02820	COG1671	Belongs to the UPF0178 family
HXV88_RS02840	COG0484	heat shock protein binding
HXV88_RS02845	COG3263	regulation of cellular component size
HXV88_RS02850	COG3722	fumarate hydratase activity
HXV88_RS02855	COG0246	Mannitol dehydrogenase
HXV88_RS02860	COG2213	PTS system mannitol-specific
HXV88_RS02860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_RS02865	COG1560	Kdo2-lipid A biosynthetic process
HXV88_RS02870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HXV88_RS02870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HXV88_RS02875	COG1538	Outer membrane efflux protein
HXV88_RS02880	COG0494	nUDIX hydrolase
HXV88_RS02885	COG3151	Protein conserved in bacteria
HXV88_RS02895	COG3150	esterase
HXV88_RS02920	COG3104	oligopeptide transport
HXV88_RS02955	COG0583	DNA-binding transcription factor activity
HXV88_RS02960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXV88_RS02980	COG0204	Acyl-transferase
HXV88_RS02985	COG1842	Phage shock protein A
HXV88_RS03000	COG2827	Endonuclease containing a URI domain
HXV88_RS03015	COG1573	uracil-dna glycosylase
HXV88_RS03020	COG0697	spore germination
HXV88_RS03025	COG0583	DNA-binding transcription factor activity
HXV88_RS03030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HXV88_RS03035	COG1121	(ABC) transporter
HXV88_RS03040	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HXV88_RS03060	COG0739	heme binding
HXV88_RS03070	COG3068	Protein conserved in bacteria
HXV88_RS03075	COG3385	transposase activity
HXV88_RS03080	COG4536	flavin adenine dinucleotide binding
HXV88_RS03085	COG4137	Cytochrome C assembly protein
HXV88_RS03090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HXV88_RS03095	COG0228	four-way junction DNA binding
HXV88_RS03100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HXV88_RS03105	COG0336	Belongs to the RNA methyltransferase TrmD family
HXV88_RS03110	COG0335	large ribosomal subunit rRNA binding
HXV88_RS03120	COG3066	DNA modification
HXV88_RS03125	COG1051	belongs to the nudix hydrolase family
HXV88_RS03135	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HXV88_RS03140	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HXV88_RS03145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HXV88_RS03155	COG0583	DNA-binding transcription factor activity
HXV88_RS03160	COG0640	Transcriptional regulator
HXV88_RS03165	COG0268	Binds directly to 16S ribosomal RNA
HXV88_RS03170	COG0728	peptidoglycan biosynthetic process
HXV88_RS03175	COG0196	riboflavin kinase activity
HXV88_RS03180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HXV88_RS03185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HXV88_RS03190	COG1047	Peptidyl-prolyl cis-trans
HXV88_RS03195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HXV88_RS03240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HXV88_RS03240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HXV88_RS03255	COG1854	S-ribosylhomocysteine lyase activity
HXV88_RS03265	COG4968	Prepilin-type N-terminal cleavage methylation domain
HXV88_RS03270	COG0084	hydrolase, TatD family'
HXV88_RS03275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HXV88_RS03285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HXV88_RS03290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HXV88_RS03295	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HXV88_RS03300	COG0813	purine-nucleoside phosphorylase activity
HXV88_RS03310	COG0560	Phosphoserine phosphatase
HXV88_RS03325	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HXV88_RS03340	COG0776	regulation of translation
HXV88_RS03350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HXV88_RS03355	COG1914	H( )-stimulated, divalent metal cation uptake system
HXV88_RS03360	COG0360	Binds together with S18 to 16S ribosomal RNA
HXV88_RS03365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HXV88_RS03370	COG0359	binds to the 23S rRNA
HXV88_RS03375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HXV88_RS03400	COG1064	alcohol dehydrogenase
HXV88_RS03405	COG1238	metal cluster binding
HXV88_RS03410	COG0612	Peptidase, M16
HXV88_RS03415	COG2918	glutathione biosynthetic process
HXV88_RS03420	COG1022	Amp-dependent synthetase and ligase
HXV88_RS03430	COG0456	acetyltransferase
HXV88_RS03445	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HXV88_RS03455	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_RS03470	COG0477	Major facilitator Superfamily
HXV88_RS03475	COG0583	DNA-binding transcription factor activity
HXV88_RS03485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXV88_RS03490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXV88_RS03500	COG0673	inositol 2-dehydrogenase activity
HXV88_RS03510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HXV88_RS03515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HXV88_RS03520	COG3036	rescue of stalled ribosome
HXV88_RS03530	COG0138	bifunctional purine biosynthesis protein purh
HXV88_RS03535	COG0151	Belongs to the GarS family
HXV88_RS03555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HXV88_RS03565	COG1610	YqeY-like protein
HXV88_RS03570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HXV88_RS03575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HXV88_RS03580	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HXV88_RS03585	COG1027	Aspartate ammonia-lyase
HXV88_RS03590	COG3030	protein affecting phage T7 exclusion by the F plasmid
HXV88_RS03595	COG0534	Mate efflux family protein
HXV88_RS03600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HXV88_RS03605	COG0459	protein refolding
HXV88_RS03670	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HXV88_RS03675	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HXV88_RS03685	COG4143	(ABC) transporter
HXV88_RS03700	COG0066	3-isopropylmalate dehydratase activity
HXV88_RS03705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HXV88_RS03710	COG0473	3-isopropylmalate dehydrogenase activity
HXV88_RS03715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HXV88_RS03740	COG0028	Belongs to the TPP enzyme family
HXV88_RS03745	COG0440	acetolactate synthase activity
HXV88_RS03760	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HXV88_RS03775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_RS03805	COG0745	RESPONSE REGULATOR receiver
HXV88_RS03810	COG3104	oligopeptide transport
HXV88_RS03815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HXV88_RS03820	COG1555	photosystem II stabilization
HXV88_RS03825	COG0280	phosphate acetyltransferase
HXV88_RS03825	COG0857	belongs to the CobB CobQ family
HXV88_RS03830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HXV88_RS03840	COG3013	Belongs to the UPF0304 family
HXV88_RS03845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HXV88_RS03850	COG2716	regulation of RNA biosynthetic process
HXV88_RS03855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXV88_RS03860	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HXV88_RS03865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HXV88_RS03875	COG0583	DNA-binding transcription factor activity
HXV88_RS03900	COG0784	Response regulator, receiver
HXV88_RS03900	COG5002	protein histidine kinase activity
HXV88_RS03900	COG2198	Histidine kinase
HXV88_RS03925	COG0840	transmembrane signaling receptor activity
HXV88_RS03935	COG1464	Belongs to the NlpA lipoprotein family
HXV88_RS03940	COG2011	ABC-type metal ion transport system permease component
HXV88_RS03945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HXV88_RS03965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HXV88_RS03965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HXV88_RS03970	COG0802	atpase or kinase
HXV88_RS03980	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HXV88_RS03985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HXV88_RS03990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HXV88_RS03995	COG1923	regulation of RNA biosynthetic process
HXV88_RS04000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HXV88_RS04005	COG0330	HflC and HflK could
HXV88_RS04010	COG0330	HflC and HflK could
HXV88_RS04015	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HXV88_RS04020	COG0142	geranyltranstransferase activity
HXV88_RS04025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HXV88_RS04030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HXV88_RS04035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HXV88_RS04055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXV88_RS04075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HXV88_RS04080	COG2967	ApaG domain
HXV88_RS04085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HXV88_RS04090	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HXV88_RS04095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HXV88_RS04100	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HXV88_RS04105	COG3178	'Phosphotransferase
HXV88_RS04110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HXV88_RS04115	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HXV88_RS04120	COG2195	Cleaves the N-terminal amino acid of tripeptides
HXV88_RS04125	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HXV88_RS04145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HXV88_RS04160	COG2350	Protein conserved in bacteria
HXV88_RS04165	COG2917	probably involved in intracellular septation
HXV88_RS04170	COG0076	glutamate decarboxylase activity
HXV88_RS04175	COG1272	protein, Hemolysin III
HXV88_RS04180	COG2985	domain, Protein
HXV88_RS04180	COG0569	domain protein
HXV88_RS04200	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HXV88_RS04225	COG2264	protein methyltransferase activity
HXV88_RS04230	COG0604	alcohol dehydrogenase
HXV88_RS04235	COG0583	DNA-binding transcription factor activity
HXV88_RS04240	COG1263	PTS System
HXV88_RS04240	COG2190	(PTS) system
HXV88_RS04240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXV88_RS04245	COG4145	pantothenate transmembrane transporter activity
HXV88_RS04255	COG0439	Biotin carboxylase
HXV88_RS04260	COG0511	ligase activity, forming carbon-carbon bonds
HXV88_RS04265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HXV88_RS04270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HXV88_RS04290	COG3381	protein complex oligomerization
HXV88_RS04300	COG3005	denitrification pathway
HXV88_RS04305	COG0745	RESPONSE REGULATOR receiver
HXV88_RS04315	COG1879	ABC-type sugar transport system periplasmic component
HXV88_RS04320	COG2198	Histidine kinase
HXV88_RS04320	COG0784	Response regulator, receiver
HXV88_RS04320	COG2205	protein histidine kinase activity
HXV88_RS04330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HXV88_RS04335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HXV88_RS04340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HXV88_RS04340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HXV88_RS04355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HXV88_RS04360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HXV88_RS04365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HXV88_RS04370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HXV88_RS04395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HXV88_RS04400	COG0142	geranyltranstransferase activity
HXV88_RS04405	COG1722	exodeoxyribonuclease VII activity
HXV88_RS04410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HXV88_RS04415	COG1360	Flagellar Motor Protein
HXV88_RS04430	COG1534	Rna-binding protein
HXV88_RS04435	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HXV88_RS04445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HXV88_RS04450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HXV88_RS04455	COG0149	triose-phosphate isomerase activity
HXV88_RS04460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HXV88_RS04475	COG0779	Required for maturation of 30S ribosomal subunits
HXV88_RS04480	COG0195	Participates in both transcription termination and antitermination
HXV88_RS04485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HXV88_RS04490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HXV88_RS04495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HXV88_RS04500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HXV88_RS04505	COG1185	polyribonucleotide nucleotidyltransferase activity
HXV88_RS04510	COG2201	protein-glutamate methylesterase activity
HXV88_RS04515	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HXV88_RS04525	COG0840	transmembrane signaling receptor activity
HXV88_RS04530	COG0835	chemotaxis
HXV88_RS04540	COG2198	Histidine kinase
HXV88_RS04540	COG0643	Histidine kinase
HXV88_RS04550	COG0745	RESPONSE REGULATOR receiver
HXV88_RS04570	COG1280	lysine exporter protein (LysE YggA)
HXV88_RS04575	COG0826	peptidase U32
HXV88_RS04580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HXV88_RS04620	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HXV88_RS04645	COG0300	oxidoreductase activity
HXV88_RS04655	COG0840	transmembrane signaling receptor activity
HXV88_RS04670	COG3501	Rhs element vgr protein
HXV88_RS04715	COG0077	Prephenate dehydratase
HXV88_RS04715	COG1605	Chorismate mutase
HXV88_RS04745	COG3272	Protein of unknown function (DUF1722)
HXV88_RS04750	COG0789	Transcriptional regulator
HXV88_RS04755	COG0415	Belongs to the DNA photolyase family
HXV88_RS04765	COG0300	oxidoreductase activity
HXV88_RS04780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HXV88_RS04810	COG1477	protein flavinylation
HXV88_RS04815	COG2871	sodium ion transport
HXV88_RS04820	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HXV88_RS04825	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HXV88_RS04830	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HXV88_RS04835	COG1805	sodium ion transport
HXV88_RS04840	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HXV88_RS04845	COG0271	Belongs to the BolA IbaG family
HXV88_RS04850	COG2813	Specifically methylates the guanine in position
HXV88_RS04860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HXV88_RS04865	COG2211	Major facilitator Superfamily
HXV88_RS04875	COG1666	GTP binding
HXV88_RS04880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HXV88_RS04895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HXV88_RS04900	COG0840	transmembrane signaling receptor activity
HXV88_RS04905	COG0583	DNA-binding transcription factor activity
HXV88_RS04915	COG2363	Small membrane protein
HXV88_RS04920	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HXV88_RS04930	COG0473	3-isopropylmalate dehydrogenase activity
HXV88_RS04935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXV88_RS04940	COG1611	Belongs to the LOG family
HXV88_RS04945	COG3706	GGDEF domain
HXV88_RS04955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HXV88_RS04955	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HXV88_RS04965	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HXV88_RS04990	COG3098	single-species biofilm formation
HXV88_RS04995	COG0564	pseudouridine synthase activity
HXV88_RS05015	COG1263	PTS System
HXV88_RS05015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXV88_RS05025	COG2171	N-acyltransferase activity
HXV88_RS05035	COG0024	Methionine aminopeptidase
HXV88_RS05040	COG0052	Belongs to the universal ribosomal protein uS2 family
HXV88_RS05045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HXV88_RS05050	COG0528	UMP kinase activity
HXV88_RS05055	COG0233	cytoplasmic translational termination
HXV88_RS05060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HXV88_RS05065	COG0575	Belongs to the CDS family
HXV88_RS05070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HXV88_RS05075	COG0750	zinc metalloprotease
HXV88_RS05090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HXV88_RS05095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXV88_RS05100	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HXV88_RS05105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HXV88_RS05110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HXV88_RS05120	COG0825	malonyl-CoA metabolic process
HXV88_RS05130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HXV88_RS05135	COG1115	amino acid carrier protein
HXV88_RS05150	COG0714	Associated with various cellular activities
HXV88_RS05165	COG3104	oligopeptide transport
HXV88_RS05170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HXV88_RS05175	COG1678	Uncharacterized ACR, COG1678
HXV88_RS05180	COG0189	ligase activity
HXV88_RS05185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HXV88_RS05195	COG3091	SprT-like family
HXV88_RS05205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HXV88_RS05215	COG0251	oxidation-reduction process
HXV88_RS05230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HXV88_RS05235	COG0739	heme binding
HXV88_RS05240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HXV88_RS05270	COG0814	amino acid
HXV88_RS05290	COG0531	amino acid
HXV88_RS05295	COG3710	Transcriptional regulator
HXV88_RS05300	COG0531	amino acid
HXV88_RS05305	COG1982	Orn Lys Arg decarboxylase major
HXV88_RS05310	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HXV88_RS05320	COG3590	peptidase
HXV88_RS05330	COG2203	Gaf domain
HXV88_RS05330	COG2199	diguanylate cyclase activity
HXV88_RS05365	COG0366	Alpha amylase catalytic
HXV88_RS05380	COG0463	Glycosyl transferase, family 2
HXV88_RS05395	COG2989	Protein conserved in bacteria
HXV88_RS05400	COG3108	Peptidase M15
HXV88_RS05410	COG2860	membrane
HXV88_RS05420	COG1196	nuclear chromosome segregation
HXV88_RS05425	COG3115	cell septum assembly
HXV88_RS05430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HXV88_RS05440	COG1328	CTP reductase activity
HXV88_RS05445	COG0602	queuosine metabolic process
HXV88_RS05475	COG1566	PFAM secretion protein HlyD family protein
HXV88_RS05480	COG1846	Transcriptional regulator
HXV88_RS05490	COG0281	malic enzyme
HXV88_RS05495	COG3290	protein histidine kinase activity
HXV88_RS05505	COG0697	spore germination
HXV88_RS05520	COG0346	lactoylglutathione lyase activity
HXV88_RS05525	COG0745	RESPONSE REGULATOR receiver
HXV88_RS05530	COG5002	protein histidine kinase activity
HXV88_RS05555	COG3142	Participates in the control of copper homeostasis
HXV88_RS05560	COG0545	Peptidyl-prolyl cis-trans isomerase
HXV88_RS05585	COG0678	peroxiredoxin activity
HXV88_RS05595	COG0019	diaminopimelate decarboxylase activity
HXV88_RS05600	COG1115	amino acid carrier protein
HXV88_RS05605	COG0095	Lipoate-protein ligase
HXV88_RS05610	COG2233	PERMEase
HXV88_RS05615	COG3706	GGDEF domain
HXV88_RS05625	COG0534	Mate efflux family protein
HXV88_RS05635	COG0281	malic enzyme
HXV88_RS05665	COG0531	amino acid
HXV88_RS05670	COG1752	Esterase of the alpha-beta hydrolase superfamily
HXV88_RS05675	COG3706	GGDEF domain
HXV88_RS05680	COG1566	PFAM secretion protein HlyD family protein
HXV88_RS05690	COG1032	radical SAM domain protein
HXV88_RS05720	COG0583	DNA-binding transcription factor activity
HXV88_RS05725	COG0673	inositol 2-dehydrogenase activity
HXV88_RS05730	COG2920	part of a sulfur-relay system
HXV88_RS05735	COG1289	transmembrane transporter activity
HXV88_RS05740	COG0670	Belongs to the BI1 family
HXV88_RS05755	COG0003	Pfam Anion-transporting ATPase
HXV88_RS05840	COG3775	system Galactitol-specific IIC component
HXV88_RS05850	COG1484	DNA-dependent DNA replication
HXV88_RS05865	COG2003	Belongs to the UPF0758 family
HXV88_RS05905	COG4983	Phage plasmid primase, P4 family domain protein
HXV88_RS05910	COG3311	Transcriptional regulator
HXV88_RS05975	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HXV88_RS05985	COG3501	Rhs element vgr protein
HXV88_RS05995	COG4104	PAAR repeat-containing protein
HXV88_RS05995	COG3209	COG3209 Rhs family protein
HXV88_RS06010	COG0582	viral genome integration into host DNA
HXV88_RS06020	COG3623	hexulose-6-phosphate isomerase
HXV88_RS06025	COG0561	phosphatase activity
HXV88_RS06050	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HXV88_RS06060	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HXV88_RS06070	COG3156	type II secretion system protein K
HXV88_RS06075	COG4795	General secretion pathway protein
HXV88_RS06080	COG2165	general secretion pathway protein
HXV88_RS06090	COG2165	general secretion pathway protein
HXV88_RS06095	COG1459	type II secretion system
HXV88_RS06100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HXV88_RS06105	COG1450	Type ii and iii secretion system protein
HXV88_RS06120	COG3409	Peptidoglycan-binding domain 1 protein
HXV88_RS06120	COG3267	Type II secretory pathway component ExeA
HXV88_RS06125	COG3437	response regulator, receiver
HXV88_RS06125	COG2770	Histidine kinase
HXV88_RS06140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HXV88_RS06145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HXV88_RS06150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_RS06160	COG2190	(PTS) system
HXV88_RS06165	COG3706	GGDEF domain
HXV88_RS06170	COG3590	peptidase
HXV88_RS06180	COG1196	nuclear chromosome segregation
HXV88_RS06180	COG3264	Mechanosensitive ion channel
HXV88_RS06185	COG0469	pyruvate kinase activity
HXV88_RS06195	COG3384	dioxygenase
HXV88_RS06200	COG0419	ATPase involved in DNA repair
HXV88_RS06205	COG0420	3'-5' exonuclease activity
HXV88_RS06215	COG2974	May be involved in recombination
HXV88_RS06220	COG0405	Gamma-glutamyltransferase
HXV88_RS06225	COG0545	Peptidyl-prolyl cis-trans isomerase
HXV88_RS06230	COG1283	sodium-dependent phosphate transmembrane transporter activity
HXV88_RS06240	COG0531	amino acid
HXV88_RS06250	COG0531	amino acid
HXV88_RS06265	COG1396	sequence-specific DNA binding
HXV88_RS06265	COG1917	Cupin 2, conserved barrel domain protein
HXV88_RS06270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_RS06290	COG2862	Uncharacterized protein family, UPF0114
HXV88_RS06300	COG0745	RESPONSE REGULATOR receiver
HXV88_RS06310	COG3038	cytochrome b561
HXV88_RS06315	COG1720	tRNA m6t6A37 methyltransferase activity
HXV88_RS06335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HXV88_RS06340	COG4988	ABC transporter
HXV88_RS06355	COG0745	RESPONSE REGULATOR receiver
HXV88_RS06365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HXV88_RS06395	COG0798	PFAM Bile acid sodium symporter
HXV88_RS06400	COG1393	Belongs to the ArsC family
HXV88_RS06405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HXV88_RS06425	COG1988	membrane-bound metal-dependent
HXV88_RS06445	COG0159	tryptophan synthase activity
HXV88_RS06450	COG0133	tryptophan synthase activity
HXV88_RS06455	COG0135	phosphoribosylanthranilate isomerase activity
HXV88_RS06455	COG0134	indole-3-glycerol-phosphate synthase activity
HXV88_RS06460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HXV88_RS06465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HXV88_RS06465	COG0512	Glutamine amidotransferase of anthranilate synthase
HXV88_RS06470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HXV88_RS06480	COG0009	L-threonylcarbamoyladenylate synthase
HXV88_RS06490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HXV88_RS06505	COG3210	domain, Protein
HXV88_RS06525	COG1946	Acyl-CoA thioesterase
HXV88_RS06530	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HXV88_RS06535	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HXV88_RS06545	COG0083	homoserine kinase activity
HXV88_RS06550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HXV88_RS06575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXV88_RS06595	COG1342	Belongs to the UPF0251 family
HXV88_RS06610	COG1309	transcriptional regulator
HXV88_RS06615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_RS06620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_RS06635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HXV88_RS06640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HXV88_RS06645	COG2089	acid synthase
HXV88_RS06655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HXV88_RS06660	COG0673	inositol 2-dehydrogenase activity
HXV88_RS06665	COG1083	cytidylyl-transferase
HXV88_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_RS06705	COG1086	Polysaccharide biosynthesis protein
HXV88_RS06730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXV88_RS06745	COG1091	dTDP-4-dehydrorhamnose reductase activity
HXV88_RS06760	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HXV88_RS06780	COG0577	efflux transmembrane transporter activity
HXV88_RS06780	COG1136	(ABC) transporter
HXV88_RS06785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_RS06790	COG1227	inorganic diphosphatase activity
HXV88_RS06795	COG0497	DNA recombination
HXV88_RS06800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HXV88_RS06805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HXV88_RS06810	COG0443	Heat shock 70 kDa protein
HXV88_RS06815	COG0484	heat shock protein binding
HXV88_RS06845	COG1285	pathogenesis
HXV88_RS06855	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXV88_RS06890	COG1566	PFAM secretion protein HlyD family protein
HXV88_RS06895	COG0577	efflux transmembrane transporter activity
HXV88_RS06895	COG1136	(ABC) transporter
HXV88_RS06900	COG1136	(ABC) transporter
HXV88_RS06900	COG0577	efflux transmembrane transporter activity
HXV88_RS06905	COG1136	(ABC) transporter
HXV88_RS06905	COG0577	efflux transmembrane transporter activity
HXV88_RS06915	COG0095	Lipoate-protein ligase
HXV88_RS06925	COG0702	epimerase
HXV88_RS06930	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HXV88_RS06935	COG1454	alcohol dehydrogenase
HXV88_RS06945	COG0564	pseudouridine synthase activity
HXV88_RS06975	COG1280	lysine exporter protein (LysE YggA)
HXV88_RS06990	COG3263	regulation of cellular component size
HXV88_RS07000	COG1876	peptidase activity
HXV88_RS07005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXV88_RS07010	COG1393	Belongs to the ArsC family
HXV88_RS07015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HXV88_RS07025	COG2003	Belongs to the UPF0758 family
HXV88_RS07075	COG3069	C4-dicarboxylate transmembrane transporter activity
HXV88_RS07080	COG1473	amidohydrolase
HXV88_RS07090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HXV88_RS07100	COG0017	Asparaginyl-tRNA synthetase
HXV88_RS07115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HXV88_RS07120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HXV88_RS07125	COG0156	8-amino-7-oxononanoate synthase activity
HXV88_RS07135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HXV88_RS07140	COG0501	Belongs to the peptidase M48B family
HXV88_RS07150	COG0633	Ferredoxin
HXV88_RS07150	COG3217	Mosc domain protein beta barrel domain protein
HXV88_RS07150	COG0633	Ferredoxin
HXV88_RS07150	COG3217	Mosc domain protein beta barrel domain protein
HXV88_RS07165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HXV88_RS07165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HXV88_RS07165	COG1013	pyruvate-flavodoxin oxidoreductase activity
HXV88_RS07165	COG0674	pyruvate-flavodoxin oxidoreductase activity
HXV88_RS07175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HXV88_RS07180	COG1607	acyl-coa hydrolase
HXV88_RS07190	COG3021	interspecies interaction between organisms
HXV88_RS07195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HXV88_RS07200	COG2027	D-alanyl-D-alanine carboxypeptidase
HXV88_RS07205	COG1061	Type III restriction enzyme res subunit
HXV88_RS07210	COG1566	PFAM secretion protein HlyD family protein
HXV88_RS07220	COG1966	Carbon starvation protein
HXV88_RS07225	COG3279	Response regulator of the LytR AlgR family
HXV88_RS07230	COG3275	phosphorelay sensor kinase activity
HXV88_RS07235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXV88_RS07235	COG2199	diguanylate cyclase activity
HXV88_RS07245	COG1846	Transcriptional regulator
HXV88_RS07245	COG1940	carbohydrate kinase activity
HXV88_RS07250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HXV88_RS07255	COG0363	glucosamine-6-phosphate deaminase activity
HXV88_RS07260	COG2190	(PTS) system
HXV88_RS07260	COG1263	PTS System
HXV88_RS07260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXV88_RS07270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXV88_RS07275	COG0735	belongs to the Fur family
HXV88_RS07285	COG0716	FMN binding
HXV88_RS07300	COG0596	Alpha beta hydrolase
HXV88_RS07305	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HXV88_RS07310	COG0033	Phosphoglucomutase
HXV88_RS07325	COG2951	lytic endotransglycosylase activity
HXV88_RS07330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HXV88_RS07335	COG4136	ATPase activity
HXV88_RS07345	COG4134	Bacterial extracellular solute-binding protein
HXV88_RS07355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HXV88_RS07365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HXV88_RS07375	COG0729	surface antigen
HXV88_RS07380	COG2911	Protein conserved in bacteria
HXV88_RS07400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HXV88_RS07410	COG0741	lytic transglycosylase activity
HXV88_RS07420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HXV88_RS07425	COG4771	TonB-dependent receptor
HXV88_RS07430	COG1169	isochorismate synthase
HXV88_RS07435	COG1021	2,3-dihydroxybenzoate-AMP ligase
HXV88_RS07440	COG3433	isochorismatase activity
HXV88_RS07440	COG1535	isochorismatase
HXV88_RS07445	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_RS07450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HXV88_RS07450	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HXV88_RS07475	COG1278	Cold shock
HXV88_RS07500	COG4166	transmembrane transport
HXV88_RS07505	COG1349	DNA-binding transcription factor activity
HXV88_RS07510	COG1882	Formate acetyltransferase
HXV88_RS07515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HXV88_RS07520	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HXV88_RS07530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXV88_RS07545	COG4166	transmembrane transport
HXV88_RS07550	COG0622	Phosphoesterase
HXV88_RS07565	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HXV88_RS07570	COG0784	Response regulator, receiver
HXV88_RS07570	COG0835	chemotaxis
HXV88_RS07575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HXV88_RS07580	COG1815	bacterial-type flagellum-dependent cell motility
HXV88_RS07600	COG4787	bacterial-type flagellum-dependent cell motility
HXV88_RS07610	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HXV88_RS07615	COG1706	bacterial-type flagellum-dependent cell motility
HXV88_RS07630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXV88_RS07635	COG2239	Acts as a magnesium transporter
HXV88_RS07645	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HXV88_RS07650	COG2716	regulation of RNA biosynthetic process
HXV88_RS07665	COG3852	Histidine kinase
HXV88_RS07675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HXV88_RS07680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HXV88_RS07685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HXV88_RS07690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HXV88_RS07710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HXV88_RS07725	COG0590	tRNA wobble adenosine to inosine editing
HXV88_RS07730	COG0573	inorganic phosphate transmembrane transporter activity
HXV88_RS07735	COG0581	inorganic phosphate transmembrane transporter activity
HXV88_RS07745	COG0704	Plays a role in the regulation of phosphate uptake
HXV88_RS07750	COG1253	flavin adenine dinucleotide binding
HXV88_RS07765	COG0531	amino acid
HXV88_RS07780	COG1126	abc transporter atp-binding protein
HXV88_RS07785	COG0765	amino acid transport
HXV88_RS07790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_RS07795	COG2199	diguanylate cyclase activity
HXV88_RS07795	COG2203	Gaf domain
HXV88_RS07800	COG2271	Major facilitator Superfamily
HXV88_RS07810	COG2197	response regulator
HXV88_RS07815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HXV88_RS07835	COG1785	Belongs to the alkaline phosphatase family
HXV88_RS07840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HXV88_RS07845	COG0123	including yeast histone deacetylase and acetoin utilization protein
HXV88_RS07855	COG1199	ATP-dependent helicase activity
HXV88_RS07870	COG1605	Chorismate mutase
HXV88_RS07870	COG0287	Prephenate dehydrogenase
HXV88_RS07875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HXV88_RS07885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXV88_RS07890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXV88_RS07925	COG0537	adenosine 5'-monophosphoramidase activity
HXV88_RS07940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HXV88_RS07955	COG1301	dicarboxylic acid transport
HXV88_RS07975	COG2354	Protein conserved in bacteria
HXV88_RS07985	COG2233	PERMEase
HXV88_RS07990	COG3150	esterase
HXV88_RS07995	COG1252	NADH dehydrogenase
HXV88_RS08005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HXV88_RS08010	COG3300	MHYT domain
HXV88_RS08010	COG5001	Diguanylate cyclase
HXV88_RS08015	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXV88_RS08025	COG2373	Large extracellular alpha-helical protein
HXV88_RS08030	COG4953	penicillin-binding protein 1C
HXV88_RS08040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXV88_RS08040	COG0301	tRNA thio-modification
HXV88_RS08055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXV88_RS08065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXV88_RS08110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HXV88_RS08120	COG2089	acid synthase
HXV88_RS08130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HXV88_RS08135	COG1083	cytidylyl-transferase
HXV88_RS08140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HXV88_RS08145	COG1086	Polysaccharide biosynthesis protein
HXV88_RS08160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HXV88_RS08175	COG0483	inositol monophosphate 1-phosphatase activity
HXV88_RS08185	COG0625	glutathione transferase activity
HXV88_RS08190	COG2814	Major facilitator Superfamily
HXV88_RS08195	COG0583	DNA-binding transcription factor activity
HXV88_RS08200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HXV88_RS08205	COG0243	molybdopterin cofactor binding
HXV88_RS08225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HXV88_RS08230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HXV88_RS08235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HXV88_RS08240	COG0509	glycine decarboxylation via glycine cleavage system
HXV88_RS08245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HXV88_RS08245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HXV88_RS08250	COG0840	transmembrane signaling receptor activity
HXV88_RS08260	COG0367	asparagine synthase
HXV88_RS08270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HXV88_RS08270	COG4651	solute:proton antiporter activity
HXV88_RS08275	COG0647	UMP catabolic process
HXV88_RS08280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HXV88_RS08290	COG1902	pentaerythritol trinitrate reductase activity
HXV88_RS08295	COG1253	flavin adenine dinucleotide binding
HXV88_RS08305	COG0247	lactate metabolic process
HXV88_RS08305	COG0277	FAD linked oxidase domain protein
HXV88_RS08315	COG2050	protein possibly involved in aromatic compounds catabolism
HXV88_RS08330	COG3300	MHYT domain
HXV88_RS08330	COG5001	Diguanylate cyclase
HXV88_RS08335	COG2056	Na+-H+ antiporter family
HXV88_RS08340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HXV88_RS08345	COG0671	phosphoesterase, PA-phosphatase related
HXV88_RS08350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HXV88_RS08355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HXV88_RS08365	COG0101	tRNA pseudouridine synthase activity
HXV88_RS08370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HXV88_RS08375	COG0285	dihydrofolate synthase activity
HXV88_RS08380	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HXV88_RS08385	COG0393	Putative heavy-metal-binding
HXV88_RS08395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXV88_RS08395	COG1648	precorrin-2 dehydrogenase activity
HXV88_RS08415	COG4667	esterase of the alpha-beta hydrolase superfamily
HXV88_RS08420	COG1619	proteins homologs of microcin C7 resistance protein MccF
HXV88_RS08425	COG1368	sulfuric ester hydrolase activity
HXV88_RS08435	COG0527	aspartate kinase activity
HXV88_RS08440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HXV88_RS08440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HXV88_RS08445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HXV88_RS08625	COG0596	Alpha beta hydrolase
HXV88_RS08645	COG1136	(ABC) transporter
HXV88_RS08660	COG2814	Major facilitator Superfamily
HXV88_RS08680	COG0672	)-iron permease
HXV88_RS08700	COG0514	ATP-dependent DNA helicase (RecQ)
HXV88_RS08720	COG3039	Transposase
HXV88_RS08735	COG2314	TM2 domain
HXV88_RS08745	COG0582	viral genome integration into host DNA
HXV88_RS08810	COG0659	secondary active sulfate transmembrane transporter activity
HXV88_RS08900	COG3501	Rhs element vgr protein
HXV88_RS08910	COG3209	COG3209 Rhs family protein
HXV88_RS08935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HXV88_RS08940	COG0326	Molecular chaperone. Has ATPase activity
HXV88_RS08945	COG4172	Belongs to the ABC transporter superfamily
HXV88_RS08950	COG4172	Belongs to the ABC transporter superfamily
HXV88_RS08960	COG4168	peptide transport system, permease
HXV88_RS08970	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HXV88_RS08975	COG1842	Phage shock protein A
HXV88_RS08990	COG3106	COG3106 Predicted ATPase
HXV88_RS08995	COG3768	UPF0283 membrane protein
HXV88_RS09005	COG2154	pterin-4-alpha-carbinolamine dehydratase
HXV88_RS09025	COG2199	diguanylate cyclase activity
HXV88_RS09030	COG2885	chlorophyll binding
HXV88_RS09035	COG0861	Integral membrane protein TerC family
HXV88_RS09065	COG2910	NAD(P)H-binding
HXV88_RS09070	COG0583	DNA-binding transcription factor activity
HXV88_RS09075	COG0583	DNA-binding transcription factor activity
HXV88_RS09080	COG2271	Major facilitator Superfamily
HXV88_RS09090	COG1335	isochorismatase
HXV88_RS09105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HXV88_RS09115	COG0583	DNA-binding transcription factor activity
HXV88_RS09120	COG2723	6-phospho-beta-galactosidase activity
HXV88_RS09125	COG1944	ATP diphosphatase activity
HXV88_RS09130	COG2116	formate transmembrane transporter activity
HXV88_RS09135	COG1882	Formate acetyltransferase
HXV88_RS09140	COG2983	Belongs to the UPF0260 family
HXV88_RS09160	COG0058	SHG alpha-glucan phosphorylase activity
HXV88_RS09165	COG0471	metal ion transport
HXV88_RS09170	COG3118	belongs to the thioredoxin family
HXV88_RS09180	COG1132	(ABC) transporter
HXV88_RS09185	COG1132	(ABC) transporter
HXV88_RS09195	COG2501	S4 domain
HXV88_RS09210	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HXV88_RS09265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HXV88_RS09270	COG1053	succinate dehydrogenase
HXV88_RS09280	COG0567	Dehydrogenase, E1 component
HXV88_RS09285	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXV88_RS09290	COG0045	succinate-CoA ligase (ADP-forming) activity
HXV88_RS09305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_RS09315	COG3842	ATPase activity
HXV88_RS09320	COG1840	ABC-type Fe3 transport system, periplasmic component
HXV88_RS09330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HXV88_RS09340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXV88_RS09355	COG4235	cytochrome complex assembly
HXV88_RS09355	COG3088	subunit of a heme lyase
HXV88_RS09365	COG1138	Cytochrome C-type biogenesis protein
HXV88_RS09370	COG3301	Polysulphide reductase, NrfD
HXV88_RS09375	COG0437	4 iron, 4 sulfur cluster binding
HXV88_RS09380	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HXV88_RS09395	COG0247	lactate metabolic process
HXV88_RS09400	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HXV88_RS09405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HXV88_RS09410	COG3012	SEC-C Motif Domain Protein
HXV88_RS09415	COG0840	transmembrane signaling receptor activity
HXV88_RS09420	COG1940	carbohydrate kinase activity
HXV88_RS09420	COG1846	Transcriptional regulator
HXV88_RS09430	COG0730	response to heat
HXV88_RS09435	COG0583	DNA-binding transcription factor activity
HXV88_RS09450	COG3593	DNA synthesis involved in DNA repair
HXV88_RS09500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HXV88_RS09505	COG1011	Hydrolase
HXV88_RS09520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HXV88_RS09525	COG2832	Protein of unknown function (DUF454)
HXV88_RS09530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HXV88_RS09540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HXV88_RS09545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HXV88_RS09560	COG1560	Kdo2-lipid A biosynthetic process
HXV88_RS09565	COG1560	Kdo2-lipid A biosynthetic process
HXV88_RS09580	COG2203	Gaf domain
HXV88_RS09580	COG2199	diguanylate cyclase activity
HXV88_RS09590	COG0417	DNA replication proofreading
HXV88_RS09605	COG1451	nucleotide metabolic process
HXV88_RS09620	COG3069	C4-dicarboxylate transmembrane transporter activity
HXV88_RS09635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_RS09635	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HXV88_RS09640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXV88_RS09645	COG0569	domain protein
HXV88_RS09645	COG2985	domain, Protein
HXV88_RS09660	COG0556	nucleotide-excision repair
HXV88_RS09670	COG0586	Pfam SNARE associated Golgi protein
HXV88_RS09675	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HXV88_RS09680	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HXV88_RS09695	COG4681	YaeQ
HXV88_RS09750	COG0307	riboflavin synthase, alpha
HXV88_RS09760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXV88_RS09765	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HXV88_RS09770	COG0697	spore germination
HXV88_RS09775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HXV88_RS09815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXV88_RS09820	COG3099	Belongs to the UPF0263 family
HXV88_RS09825	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HXV88_RS09830	COG2894	cell division
HXV88_RS09835	COG0850	regulation of cytokinetic process
HXV88_RS09840	COG3100	YcgL domain-containing protein
HXV88_RS09845	COG1760	l-serine dehydratase
HXV88_RS09850	COG1760	l-serine dehydratase
HXV88_RS09855	COG3123	guanosine phosphorylase activity
HXV88_RS09865	COG0205	6-phosphofructokinase activity
HXV88_RS09875	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HXV88_RS09880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HXV88_RS09890	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HXV88_RS09895	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HXV88_RS09900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HXV88_RS09915	COG0242	peptide deformylase activity
HXV88_RS09945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HXV88_RS09950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HXV88_RS09955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXV88_RS09965	COG0549	Belongs to the carbamate kinase family
HXV88_RS09980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXV88_RS09990	COG0697	spore germination
HXV88_RS10000	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HXV88_RS10000	COG3608	succinylglutamate desuccinylase aspartoacylase
HXV88_RS10005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HXV88_RS10010	COG2068	MobA-Related Protein
HXV88_RS10015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXV88_RS10015	COG0493	'glutamate synthase
HXV88_RS10020	COG0402	S-adenosylhomocysteine deaminase activity
HXV88_RS10025	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HXV88_RS10030	COG2080	2 iron, 2 sulfur cluster binding
HXV88_RS10030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HXV88_RS10035	COG2233	PERMEase
HXV88_RS10040	COG0402	S-adenosylhomocysteine deaminase activity
HXV88_RS10045	COG2252	PERMEase
HXV88_RS10050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HXV88_RS10055	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HXV88_RS10060	COG2080	2 iron, 2 sulfur cluster binding
HXV88_RS10065	COG3134	Outer membrane lipoprotein
HXV88_RS10080	COG0318	PFAM AMP-dependent synthetase and ligase
HXV88_RS10085	COG3706	GGDEF domain
HXV88_RS10100	COG0107	imidazoleglycerol-phosphate synthase activity
HXV88_RS10105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HXV88_RS10110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HXV88_RS10115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HXV88_RS10115	COG0131	Imidazoleglycerol-phosphate dehydratase
HXV88_RS10120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HXV88_RS10125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HXV88_RS10130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HXV88_RS10140	COG1199	ATP-dependent helicase activity
HXV88_RS10145	COG1214	PFAM Peptidase M22, glycoprotease
HXV88_RS10155	COG2267	carboxylic ester hydrolase activity
HXV88_RS10160	COG0318	PFAM AMP-dependent synthetase and ligase
HXV88_RS10170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXV88_RS10175	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HXV88_RS10180	COG0709	Synthesizes selenophosphate from selenide and ATP
HXV88_RS10195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HXV88_RS10200	COG0840	transmembrane signaling receptor activity
HXV88_RS10205	COG1254	Belongs to the acylphosphatase family
HXV88_RS10215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXV88_RS10215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXV88_RS10220	COG0489	protein tyrosine kinase activity
HXV88_RS10225	COG0572	uridine kinase
HXV88_RS10230	COG0717	Belongs to the dCTP deaminase family
HXV88_RS10235	COG0306	phosphate transporter
HXV88_RS10240	COG3313	Fe-S protein
HXV88_RS10245	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HXV88_RS10250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HXV88_RS10255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HXV88_RS10260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HXV88_RS10270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HXV88_RS10280	COG0366	Alpha amylase catalytic
HXV88_RS10300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HXV88_RS10305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HXV88_RS10310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HXV88_RS10315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HXV88_RS10320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HXV88_RS10325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXV88_RS10325	COG0072	phenylalanine-tRNA ligase activity
HXV88_RS10330	COG0776	regulation of translation
HXV88_RS10335	COG2205	protein histidine kinase activity
HXV88_RS10335	COG0784	Response regulator, receiver
HXV88_RS10360	COG3300	MHYT domain
HXV88_RS10360	COG5001	Diguanylate cyclase
HXV88_RS10365	COG1609	Transcriptional regulator
HXV88_RS10370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXV88_RS10375	COG1879	ABC-type sugar transport system periplasmic component
HXV88_RS10380	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXV88_RS10385	COG1129	ABC transporter
HXV88_RS10390	COG1869	D-ribose catabolic process
HXV88_RS10425	COG1177	transmembrane transport
HXV88_RS10450	COG0037	tRNA processing
HXV88_RS10455	COG0589	response to stress
HXV88_RS10460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HXV88_RS10475	COG2217	Heavy metal translocating P-type atpase
HXV88_RS10485	COG2010	Cytochrome c
HXV88_RS10500	COG3278	Belongs to the heme-copper respiratory oxidase family
HXV88_RS10510	COG1956	GAF domain-containing protein
HXV88_RS10515	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HXV88_RS10525	COG0308	aminopeptidase N
HXV88_RS10535	COG2902	Dehydrogenase
HXV88_RS10540	COG0167	dihydroorotate dehydrogenase activity
HXV88_RS10555	COG0254	rRNA binding
HXV88_RS10560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HXV88_RS10565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HXV88_RS10565	COG0116	Belongs to the methyltransferase superfamily
HXV88_RS10585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXV88_RS10590	COG1067	ATP-dependent peptidase activity
HXV88_RS10605	COG4128	Pfam Zonular occludens toxin
HXV88_RS10655	COG4128	Pfam Zonular occludens toxin
HXV88_RS10710	COG3141	response to X-ray
HXV88_RS10715	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HXV88_RS10720	COG4221	oxidoreductase activity
HXV88_RS10765	COG0372	Belongs to the citrate synthase family
HXV88_RS10770	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HXV88_RS10780	COG2995	paraquat-inducible protein a
HXV88_RS10785	COG3008	intermembrane lipid transfer
HXV88_RS10790	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HXV88_RS10790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HXV88_RS10805	COG0084	hydrolase, TatD family'
HXV88_RS10810	COG0470	DNA polymerase III
HXV88_RS10815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HXV88_RS10820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HXV88_RS10825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HXV88_RS10830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXV88_RS10835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXV88_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_RS10850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HXV88_RS10855	COG0416	fatty acid biosynthetic process
HXV88_RS10860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HXV88_RS10865	COG1399	metal-binding, possibly nucleic acid-binding protein
HXV88_RS10870	COG0424	maF-like protein
HXV88_RS10885	COG1530	ribonuclease E activity
HXV88_RS10890	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HXV88_RS10890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_RS10890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_RS10895	COG1105	Belongs to the carbohydrate kinase PfkB family
HXV88_RS10900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_RS10900	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_RS10905	COG1609	Transcriptional regulator
HXV88_RS10910	COG0814	amino acid
HXV88_RS10930	COG0513	Belongs to the DEAD box helicase family
HXV88_RS10940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HXV88_RS10945	COG2890	protein-(glutamine-N5) methyltransferase activity
HXV88_RS10950	COG2840	Smr protein MutS2
HXV88_RS10955	COG3706	GGDEF domain
HXV88_RS10960	COG0406	alpha-ribazole phosphatase activity
HXV88_RS10980	COG2824	Alkylphosphonate utilization operon protein PhnA
HXV88_RS10995	COG0494	nUDIX hydrolase
HXV88_RS11000	COG0814	amino acid
HXV88_RS11005	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HXV88_RS11010	COG0514	ATP-dependent DNA helicase (RecQ)
HXV88_RS11015	COG2766	serine protein kinase
HXV88_RS11020	COG2718	Belongs to the UPF0229 family
HXV88_RS11025	COG2719	SpoVR family
HXV88_RS11030	COG1024	Enoyl-CoA hydratase
HXV88_RS11030	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXV88_RS11035	COG0183	Belongs to the thiolase family
HXV88_RS11040	COG0714	Associated with various cellular activities
HXV88_RS11060	COG2304	oxidoreductase activity
HXV88_RS11070	COG1595	DNA-templated transcription, initiation
HXV88_RS11080	COG2067	long-chain fatty acid transport protein
HXV88_RS11085	COG2067	long-chain fatty acid transport protein
HXV88_RS11090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HXV88_RS11105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HXV88_RS11115	COG1643	Atp-dependent helicase
HXV88_RS11120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HXV88_RS11120	COG0617	tRNA 3'-terminal CCA addition
HXV88_RS11120	COG0517	IMP dehydrogenase activity
HXV88_RS11125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXV88_RS11130	COG3119	arylsulfatase activity
HXV88_RS11135	COG0714	Associated with various cellular activities
HXV88_RS11150	COG2304	oxidoreductase activity
HXV88_RS11155	COG2304	oxidoreductase activity
HXV88_RS11185	COG0641	radical SAM
HXV88_RS11190	COG2925	Exonuclease
HXV88_RS11200	COG3345	alpha-galactosidase
HXV88_RS11205	COG1380	Effector of murein hydrolase LrgA
HXV88_RS11210	COG1346	cytolysis
HXV88_RS11215	COG0295	cytidine deaminase activity
HXV88_RS11220	COG3033	Beta-eliminating lyase
HXV88_RS11230	COG3046	protein related to deoxyribodipyrimidine photolyase
HXV88_RS11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_RS11240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HXV88_RS11265	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXV88_RS11280	COG3158	transport of potassium into the cell
HXV88_RS11295	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXV88_RS11300	COG0651	ATP synthesis coupled electron transport
HXV88_RS11305	COG0650	Formate hydrogenlyase subunit 4
HXV88_RS11310	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HXV88_RS11310	COG3261	NADH dehydrogenase
HXV88_RS11315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_RS11320	COG3260	NADH ubiquinone oxidoreductase 20
HXV88_RS11330	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HXV88_RS11340	COG1921	L-seryl-tRNASec selenium transferase activity
HXV88_RS11350	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HXV88_RS11355	COG0298	carbon dioxide binding
HXV88_RS11365	COG0309	Hydrogenase expression formation protein (HypE)
HXV88_RS11370	COG0375	protein maturation
HXV88_RS11375	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HXV88_RS11380	COG1124	(ABC) transporter
HXV88_RS11385	COG0444	Belongs to the ABC transporter superfamily
HXV88_RS11390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXV88_RS11405	COG1773	rubredoxin
HXV88_RS11410	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HXV88_RS11415	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HXV88_RS11420	COG5557	Pfam Polysulphide reductase, NrfD
HXV88_RS11425	COG0437	4 iron, 4 sulfur cluster binding
HXV88_RS11430	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HXV88_RS11435	COG4251	negative regulation of phosphorylation
HXV88_RS11435	COG2203	Gaf domain
HXV88_RS11435	COG3706	GGDEF domain
HXV88_RS11435	COG5001	Diguanylate cyclase
HXV88_RS11440	COG0438	transferase activity, transferring glycosyl groups
HXV88_RS11445	COG0438	transferase activity, transferring glycosyl groups
HXV88_RS11465	COG0438	transferase activity, transferring glycosyl groups
HXV88_RS11495	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HXV88_RS11510	COG0438	transferase activity, transferring glycosyl groups
HXV88_RS11515	COG1215	transferase activity, transferring glycosyl groups
HXV88_RS11520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXV88_RS11560	COG0784	Response regulator, receiver
HXV88_RS11560	COG2205	protein histidine kinase activity
HXV88_RS11595	COG0730	response to heat
HXV88_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_RS11615	COG1024	Enoyl-CoA hydratase
HXV88_RS11620	COG1024	Enoyl-CoA hydratase
HXV88_RS11625	COG1960	acyl-CoA dehydrogenase activity
HXV88_RS11630	COG1960	acyl-CoA dehydrogenase activity
HXV88_RS11635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HXV88_RS11640	COG1024	Enoyl-CoA hydratase
HXV88_RS11670	COG1584	GPR1 FUN34 yaaH family protein
HXV88_RS11675	COG4974	Belongs to the 'phage' integrase family
HXV88_RS11760	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HXV88_RS11765	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HXV88_RS11775	COG1073	alpha beta
HXV88_RS11780	COG0583	DNA-binding transcription factor activity
HXV88_RS11785	COG1073	alpha beta
HXV88_RS11800	COG1115	amino acid carrier protein
HXV88_RS11830	COG4695	Portal protein
HXV88_RS11835	COG1024	Enoyl-CoA hydratase
HXV88_RS11850	COG3162	membrane
HXV88_RS11855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXV88_RS12015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HXV88_RS12020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HXV88_RS12085	COG2319	Wd-40 repeat
HXV88_RS12085	COG1672	PFAM Archaeal ATPase
HXV88_RS12170	COG0582	viral genome integration into host DNA
HXV88_RS12175	COG0488	(ABC) transporter
HXV88_RS12180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HXV88_RS12185	COG0776	regulation of translation
HXV88_RS12190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HXV88_RS12195	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HXV88_RS12200	COG0740	serine-type endopeptidase activity
HXV88_RS12205	COG0544	peptidyl-prolyl cis-trans isomerase activity
HXV88_RS12215	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HXV88_RS12220	COG4591	ABC-type transport system involved in lipoprotein release permease component
HXV88_RS12225	COG1136	(ABC) transporter
HXV88_RS12230	COG4591	ABC-type transport system involved in lipoprotein release permease component
HXV88_RS12240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HXV88_RS12245	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HXV88_RS12255	COG0697	spore germination
HXV88_RS12265	COG2062	phosphohistidine phosphatase, SixA
HXV88_RS12270	COG1025	Belongs to the peptidase M16 family
HXV88_RS12305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HXV88_RS12305	COG0519	Catalyzes the synthesis of GMP from XMP
HXV88_RS12310	COG0517	IMP dehydrogenase activity
HXV88_RS12310	COG0516	GMP reductase activity
HXV88_RS12315	COG3038	cytochrome b561
HXV88_RS12320	COG1570	exodeoxyribonuclease VII activity
HXV88_RS12325	COG2188	Transcriptional regulator
HXV88_RS12330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_RS12330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_RS12330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_RS12335	COG0383	alpha-mannosidase activity
HXV88_RS12340	COG1181	Belongs to the D-alanine--D-alanine ligase family
HXV88_RS12350	COG0386	Belongs to the glutathione peroxidase family
HXV88_RS12355	COG0513	Belongs to the DEAD box helicase family
HXV88_RS12370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HXV88_RS12375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HXV88_RS12380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HXV88_RS12430	COG5001	Diguanylate cyclase
HXV88_RS12430	COG3300	MHYT domain
HXV88_RS12445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXV88_RS12455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HXV88_RS12460	COG0563	adenylate kinase activity
HXV88_RS12470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HXV88_RS12475	COG1286	toxin biosynthetic process
HXV88_RS12485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HXV88_RS12490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HXV88_RS12495	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HXV88_RS12500	COG0531	amino acid
HXV88_RS12500	COG1674	ftsk spoiiie
HXV88_RS12510	COG0686	Belongs to the AlaDH PNT family
HXV88_RS12515	COG0492	ferredoxin-NADP+ reductase activity
HXV88_RS12520	COG3706	GGDEF domain
HXV88_RS12525	COG3134	Outer membrane lipoprotein
HXV88_RS12530	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HXV88_RS12535	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HXV88_RS12540	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HXV88_RS12545	COG0542	response to heat
HXV88_RS12550	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HXV88_RS12555	COG1278	Cold shock
HXV88_RS12560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HXV88_RS12580	COG0745	RESPONSE REGULATOR receiver
HXV88_RS12585	COG2205	protein histidine kinase activity
HXV88_RS12595	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HXV88_RS12595	COG0392	lysyltransferase activity
HXV88_RS12620	COG1435	thymidine kinase activity
HXV88_RS12625	COG1757	Na H antiporter
HXV88_RS12630	COG2916	Histone family protein nucleoid-structuring protein H-NS
HXV88_RS12635	COG2096	Adenosyltransferase
HXV88_RS12640	COG3530	Putative quorum-sensing-regulated virulence factor
HXV88_RS12645	COG0602	queuosine metabolic process
HXV88_RS12650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HXV88_RS12670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HXV88_RS12680	COG0776	regulation of translation
HXV88_RS12685	COG0539	negative regulation of cytoplasmic translation
HXV88_RS12690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HXV88_RS12695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HXV88_RS12710	COG2814	Major facilitator Superfamily
HXV88_RS12730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HXV88_RS12735	COG5001	Diguanylate cyclase
HXV88_RS12735	COG3300	MHYT domain
HXV88_RS12740	COG0583	DNA-binding transcription factor activity
HXV88_RS12745	COG3437	response regulator, receiver
HXV88_RS12770	COG4989	oxidoreductase activity
HXV88_RS12775	COG0724	RNA recognition motif
HXV88_RS12785	COG1126	abc transporter atp-binding protein
HXV88_RS12790	COG0765	amino acid transport
HXV88_RS12800	COG4597	amino acid ABC transporter
HXV88_RS12805	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HXV88_RS12815	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HXV88_RS12830	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HXV88_RS12835	COG1360	Flagellar Motor Protein
HXV88_RS12840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_RS12845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_RS12850	COG0649	NAD binding
HXV88_RS12850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_RS12865	COG1034	ATP synthesis coupled electron transport
HXV88_RS12870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HXV88_RS12875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_RS12880	COG0839	Belongs to the complex I subunit 6 family
HXV88_RS12885	COG0713	ATP synthesis coupled electron transport
HXV88_RS12895	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_RS12900	COG1007	ATP synthesis coupled electron transport
HXV88_RS12915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXV88_RS12915	COG2199	diguanylate cyclase activity
HXV88_RS12920	COG0047	phosphoribosylformylglycinamidine synthase activity
HXV88_RS12920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HXV88_RS12925	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HXV88_RS12930	COG1645	bacterial-type flagellum-dependent swarming motility
HXV88_RS12935	COG1160	GTP binding
HXV88_RS12940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HXV88_RS12945	COG2976	Protein conserved in bacteria
HXV88_RS12950	COG0124	histidyl-tRNA synthetase
HXV88_RS12970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HXV88_RS12975	COG0105	UTP biosynthetic process
HXV88_RS12990	COG0633	Ferredoxin
HXV88_RS12995	COG0443	Heat shock 70 kDa protein
HXV88_RS13000	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HXV88_RS13010	COG0822	iron-sulfur transferase activity
HXV88_RS13015	COG1104	cysteine desulfurase activity
HXV88_RS13035	COG3154	lipid carrier protein
HXV88_RS13040	COG0826	peptidase U32
HXV88_RS13045	COG0826	peptidase U32
HXV88_RS13060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXV88_RS13065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXV88_RS13070	COG1862	Preprotein translocase
HXV88_RS13075	COG0343	queuine tRNA-ribosyltransferase activity
HXV88_RS13080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HXV88_RS13085	COG0517	IMP dehydrogenase activity
HXV88_RS13095	COG3634	alkyl hydroperoxide reductase activity
HXV88_RS13140	COG1242	4 iron, 4 sulfur cluster binding
HXV88_RS13145	COG0070	glutamate synthase
HXV88_RS13145	COG0067	glutamate synthase
HXV88_RS13145	COG0069	glutamate synthase activity
HXV88_RS13150	COG0493	'glutamate synthase
HXV88_RS13160	COG0513	Belongs to the DEAD box helicase family
HXV88_RS13185	COG0023	Translation Initiation Factor
HXV88_RS13190	COG2119	membrane
HXV88_RS13240	COG0215	cysteine-tRNA ligase activity
HXV88_RS13245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HXV88_RS13255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HXV88_RS13265	COG2261	transglycosylase associated protein
HXV88_RS13270	COG0642	Histidine kinase
HXV88_RS13295	COG0625	glutathione transferase activity
HXV88_RS13305	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HXV88_RS13320	COG0564	pseudouridine synthase activity
HXV88_RS13325	COG4160	amino acid transport
HXV88_RS13335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_RS13345	COG2431	L-lysine efflux transmembrane transporter activity
HXV88_RS13350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HXV88_RS13355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_RS13360	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HXV88_RS13370	COG1393	Belongs to the ArsC family
HXV88_RS13380	COG4783	chaperone-mediated protein folding
HXV88_RS13410	COG3842	ATPase activity
HXV88_RS13415	COG3833	ABC-type maltose transport systems, permease component
HXV88_RS13420	COG1175	transmembrane transport
HXV88_RS13430	COG3081	Nucleoid-associated protein
HXV88_RS13435	COG3082	Protein of unknown function (DUF1414)
HXV88_RS13440	COG3083	sulfuric ester hydrolase activity
HXV88_RS13445	COG1464	Belongs to the NlpA lipoprotein family
HXV88_RS13460	COG0574	Belongs to the PEP-utilizing enzyme family
HXV88_RS13460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXV88_RS13465	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HXV88_RS13540	COG0322	excinuclease ABC activity
HXV88_RS13545	COG2197	response regulator
HXV88_RS13550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HXV88_RS13555	COG2835	tetraacyldisaccharide 4'-kinase activity
HXV88_RS13560	COG1663	tetraacyldisaccharide 4'-kinase activity
HXV88_RS13570	COG0658	competence protein
HXV88_RS13570	COG2333	competence protein COMEC
HXV88_RS13585	COG1448	Aminotransferase
HXV88_RS13595	COG0583	DNA-binding transcription factor activity
HXV88_RS13600	COG3085	chromosome segregation
HXV88_RS13605	COG4574	serine-type endopeptidase inhibitor activity
HXV88_RS13610	COG0584	glycerophosphoryl diester phosphodiesterase
HXV88_RS13620	COG1349	DNA-binding transcription factor activity
HXV88_RS13625	COG2271	Major facilitator Superfamily
HXV88_RS13630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HXV88_RS13635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HXV88_RS13640	COG0840	transmembrane signaling receptor activity
HXV88_RS13650	COG0583	DNA-binding transcription factor activity
HXV88_RS13670	COG0656	L-ascorbic acid biosynthetic process
HXV88_RS13680	COG2814	Major facilitator Superfamily
HXV88_RS13685	COG2249	NAD(P)H dehydrogenase (quinone) activity
HXV88_RS13700	COG3220	belongs to the UPF0276 family
HXV88_RS13720	COG1294	oxidase, subunit
HXV88_RS13730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXV88_RS13740	COG2979	Protein of unknown function (DUF533)
HXV88_RS13755	COG0583	DNA-binding transcription factor activity
HXV88_RS13760	COG2807	transmembrane transport
HXV88_RS13765	COG1187	pseudouridine synthase activity
HXV88_RS13775	COG0346	lactoylglutathione lyase activity
HXV88_RS13785	COG1403	HNH endonuclease
HXV88_RS13790	COG4657	Part of a membrane complex involved in electron transport
HXV88_RS13795	COG2878	Part of a membrane complex involved in electron transport
HXV88_RS13805	COG4658	electron transport chain
HXV88_RS13810	COG4659	FMN binding
HXV88_RS13815	COG4660	Part of a membrane complex involved in electron transport
HXV88_RS13820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HXV88_RS13825	COG0346	lactoylglutathione lyase activity
HXV88_RS13865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HXV88_RS13870	COG0505	Belongs to the CarA family
HXV88_RS13875	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HXV88_RS13890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HXV88_RS13895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HXV88_RS13900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HXV88_RS13905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HXV88_RS13910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HXV88_RS13920	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HXV88_RS13950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HXV88_RS13955	COG0861	Integral membrane protein TerC family
HXV88_RS13970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXV88_RS13975	COG0601	transmembrane transport
HXV88_RS13985	COG2095	MarC family integral membrane protein
HXV88_RS13990	COG1012	belongs to the aldehyde dehydrogenase family
HXV88_RS13990	COG1454	alcohol dehydrogenase
HXV88_RS13995	COG0217	transcriptional regulatory protein
HXV88_RS14000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HXV88_RS14010	COG1801	Protein of unknown function DUF72
HXV88_RS14015	COG4106	trans-aconitate 2-methyltransferase activity
HXV88_RS14020	COG0500	methyltransferase
HXV88_RS14040	COG0450	alkyl hydroperoxide reductase
HXV88_RS14045	COG0583	DNA-binding transcription factor activity
HXV88_RS14050	COG0791	NLP P60 protein
HXV88_RS14060	COG0583	DNA-binding transcription factor activity
HXV88_RS14065	COG2610	gluconate transmembrane transporter activity
HXV88_RS14070	COG3048	D-serine ammonia-lyase activity
HXV88_RS14080	COG0538	isocitrate dehydrogenase activity
HXV88_RS14085	COG2207	Transcriptional regulator
HXV88_RS14090	COG1482	cell wall glycoprotein biosynthetic process
HXV88_RS14095	COG0840	transmembrane signaling receptor activity
HXV88_RS14100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_RS14115	COG3152	Membrane
HXV88_RS14150	COG1309	transcriptional regulator
HXV88_RS14180	COG0534	Mate efflux family protein
HXV88_RS14190	COG2841	Protein conserved in bacteria
HXV88_RS14200	COG3300	MHYT domain
HXV88_RS14200	COG5001	Diguanylate cyclase
HXV88_RS14205	COG3132	Protein of unknown function, DUF480
HXV88_RS14235	COG0708	Exodeoxyribonuclease III
HXV88_RS14270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_RS14275	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_RS14290	COG1120	ATPase activity
HXV88_RS14295	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXV88_RS14300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXV88_RS14305	COG2375	cellular response to nickel ion
HXV88_RS14310	COG3437	response regulator, receiver
HXV88_RS14310	COG0784	Response regulator, receiver
HXV88_RS14320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HXV88_RS14325	COG0328	RNA-DNA hybrid ribonuclease activity
HXV88_RS14330	COG2226	methyltransferase
HXV88_RS14335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXV88_RS14340	COG0741	lytic transglycosylase activity
HXV88_RS14340	COG1388	LysM domain
HXV88_RS14365	COG5000	phosphorelay sensor kinase activity
HXV88_RS14365	COG5002	protein histidine kinase activity
HXV88_RS14370	COG0745	RESPONSE REGULATOR receiver
HXV88_RS14375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_RS14380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_RS14405	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HXV88_RS14410	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HXV88_RS14465	COG1376	ErfK ybiS ycfS ynhG family protein
HXV88_RS14465	COG1388	LysM domain
HXV88_RS14475	COG0471	metal ion transport
HXV88_RS14485	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HXV88_RS14490	COG0791	NLP P60 protein
HXV88_RS14500	COG3118	belongs to the thioredoxin family
HXV88_RS14510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HXV88_RS14515	COG0788	formyltetrahydrofolate deformylase activity
HXV88_RS14525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HXV88_RS14540	COG1196	nuclear chromosome segregation
HXV88_RS14540	COG0741	lytic transglycosylase activity
HXV88_RS14540	COG0739	heme binding
HXV88_RS14545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HXV88_RS14555	COG0436	Aminotransferase
HXV88_RS14560	COG1288	antiporter activity
HXV88_RS14565	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HXV88_RS14580	COG2964	Protein conserved in bacteria
HXV88_RS14585	COG3681	Belongs to the UPF0597 family
HXV88_RS14595	COG0814	amino acid
HXV88_RS14615	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HXV88_RS14625	COG1166	arginine decarboxylase activity
HXV88_RS14630	COG2195	Cleaves the N-terminal amino acid of tripeptides
HXV88_RS14645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HXV88_RS14655	COG2353	YceI-like domain
HXV88_RS14660	COG0583	DNA-binding transcription factor activity
HXV88_RS14670	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HXV88_RS14675	COG0840	transmembrane signaling receptor activity
HXV88_RS14680	COG0302	gtp cyclohydrolase
HXV88_RS14690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HXV88_RS14710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HXV88_RS14725	COG0314	molybdopterin synthase activity
HXV88_RS14730	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HXV88_RS14735	COG0315	cyclic pyranopterin monophosphate synthase activity
HXV88_RS14740	COG0521	Mo-molybdopterin cofactor biosynthetic process
HXV88_RS14745	COG3005	denitrification pathway
HXV88_RS14755	COG0348	domain, Protein
HXV88_RS14760	COG0437	4 iron, 4 sulfur cluster binding
HXV88_RS14765	COG0243	molybdopterin cofactor binding
HXV88_RS14775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXV88_RS14780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HXV88_RS14785	COG3850	Histidine kinase
HXV88_RS14790	COG2197	response regulator
HXV88_RS14820	COG0121	glutamine amidotransferase
HXV88_RS14825	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HXV88_RS14830	COG1960	acyl-CoA dehydrogenase activity
HXV88_RS14835	COG1473	amidohydrolase
HXV88_RS14840	COG2914	Belongs to the UPF0125 (RnfH) family
HXV88_RS14845	COG2867	negative regulation of translational initiation
HXV88_RS14850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HXV88_RS14860	COG0784	Response regulator, receiver
HXV88_RS14860	COG2205	protein histidine kinase activity
HXV88_RS14870	COG3383	formate dehydrogenase (NAD+) activity
HXV88_RS14910	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXV88_RS14915	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXV88_RS14920	COG1129	ABC transporter
HXV88_RS14930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HXV88_RS14955	COG1061	Type III restriction enzyme res subunit
HXV88_RS14965	COG2003	Belongs to the UPF0758 family
HXV88_RS15005	COG5377	YqaJ viral recombinase family
HXV88_RS15110	COG0785	Cytochrome C biogenesis protein
HXV88_RS15155	COG0753	catalase activity
HXV88_RS15165	COG0641	radical SAM
HXV88_RS15170	COG3119	arylsulfatase activity
HXV88_RS15195	COG3311	Transcriptional regulator
HXV88_RS15200	COG4983	Phage plasmid primase, P4 family domain protein
HXV88_RS15240	COG2003	Belongs to the UPF0758 family
HXV88_RS15275	COG2003	Belongs to the UPF0758 family
HXV88_RS15300	COG1203	CRISPR-associated helicase, Cas3
HXV88_RS15305	COG1518	maintenance of DNA repeat elements
HXV88_RS15335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HXV88_RS15345	COG1960	acyl-CoA dehydrogenase activity
HXV88_RS15350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_RS15360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HXV88_RS15365	COG1317	bacterial-type flagellum organization
HXV88_RS15530	COG4790	Type iii secretion
HXV88_RS15535	COG4794	Type iii secretion
HXV88_RS15540	COG4791	protein targeting
HXV88_RS15545	COG4792	protein secretion
HXV88_RS15570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HXV88_RS15575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXV88_RS15575	COG1263	PTS System
HXV88_RS15580	COG1609	Transcriptional regulator
HXV88_RS15590	COG0789	Transcriptional regulator
HXV88_RS15605	COG0783	Belongs to the Dps family
HXV88_RS15630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_RS15630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_RS15630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_RS15635	COG2271	Major facilitator Superfamily
HXV88_RS15640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_RS15650	COG1187	pseudouridine synthase activity
HXV88_RS15660	COG0482	sulfurtransferase activity
HXV88_RS15665	COG2915	High frequency lysogenization protein hflD homolog
HXV88_RS15670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HXV88_RS15675	COG2850	peptidyl-arginine hydroxylation
HXV88_RS15695	COG0625	glutathione transferase activity
HXV88_RS15700	COG0259	pyridoxamine-phosphate oxidase activity
HXV88_RS15705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HXV88_RS15705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HXV88_RS15710	COG0251	oxidation-reduction process
HXV88_RS15715	COG1882	Formate acetyltransferase
HXV88_RS15720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HXV88_RS15730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HXV88_RS15735	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HXV88_RS15755	COG3088	subunit of a heme lyase
HXV88_RS15755	COG4235	cytochrome complex assembly
HXV88_RS15760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXV88_RS15765	COG1138	Cytochrome C-type biogenesis protein
HXV88_RS15770	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HXV88_RS15775	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXV88_RS15780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXV88_RS15785	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXV88_RS15800	COG0835	chemotaxis
HXV88_RS15810	COG1192	Involved in chromosome partitioning
HXV88_RS15815	COG1360	Flagellar Motor Protein
HXV88_RS15820	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HXV88_RS15830	COG2198	Histidine kinase
HXV88_RS15830	COG0784	Response regulator, receiver
HXV88_RS15830	COG0643	Histidine kinase
HXV88_RS15835	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HXV88_RS15860	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HXV88_RS15870	COG1684	flagellar biosynthetic protein fliR
HXV88_RS15875	COG1987	bacterial-type flagellum assembly
HXV88_RS15925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HXV88_RS15935	COG1677	Flagellar hook-basal body complex protein FliE
HXV88_RS15955	COG0469	pyruvate kinase activity
HXV88_RS15960	COG1737	Transcriptional regulator
HXV88_RS15965	COG0837	glucose binding
HXV88_RS15995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_RS16015	COG0281	malic enzyme
HXV88_RS16035	COG0437	4 iron, 4 sulfur cluster binding
HXV88_RS16040	COG3383	formate dehydrogenase (NAD+) activity
HXV88_RS16040	COG3383	formate dehydrogenase (NAD+) activity
HXV88_RS16075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HXV88_RS16085	COG3852	Histidine kinase
HXV88_RS16100	COG4662	Binding-protein-dependent transport system inner membrane component
HXV88_RS16110	COG0746	molybdenum cofactor guanylyltransferase activity
HXV88_RS16115	COG0303	'Molybdopterin
HXV88_RS16120	COG1289	transmembrane transporter activity
HXV88_RS16125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXV88_RS16155	COG3220	belongs to the UPF0276 family
HXV88_RS16185	COG2205	protein histidine kinase activity
HXV88_RS16185	COG0784	Response regulator, receiver
HXV88_RS16200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXV88_RS16205	COG0444	Belongs to the ABC transporter superfamily
HXV88_RS16210	COG4608	Belongs to the ABC transporter superfamily
HXV88_RS16220	COG2971	BadF BadG BcrA BcrD
HXV88_RS16230	COG0840	transmembrane signaling receptor activity
HXV88_RS16250	COG3724	N-succinylarginine dihydrolase activity
HXV88_RS16280	COG2197	response regulator
HXV88_RS16305	COG2203	Gaf domain
HXV88_RS16305	COG2200	EAL domain
HXV88_RS16305	COG2199	diguanylate cyclase activity
HXV88_RS16315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXV88_RS16320	COG1422	Protein of unknown function (DUF1090)
HXV88_RS16325	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HXV88_RS16330	COG3706	GGDEF domain
HXV88_RS16335	COG2211	Major facilitator Superfamily
HXV88_RS16340	COG0616	signal peptide processing
HXV88_RS16345	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_RS16350	COG0583	DNA-binding transcription factor activity
HXV88_RS16360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HXV88_RS16380	COG1881	PFAM PEBP family protein
HXV88_RS16395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HXV88_RS16410	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HXV88_RS16415	COG2912	Transglutaminase-like superfamily
HXV88_RS16425	COG2890	protein-(glutamine-N5) methyltransferase activity
HXV88_RS16430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HXV88_RS16435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HXV88_RS16440	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HXV88_RS16445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HXV88_RS16455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HXV88_RS16460	COG0737	Belongs to the 5'-nucleotidase family
HXV88_RS16465	COG0193	aminoacyl-tRNA hydrolase activity
HXV88_RS16470	COG0012	GTP binding
HXV88_RS16515	COG0490	domain, Protein
HXV88_RS16515	COG0471	metal ion transport
HXV88_RS16525	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HXV88_RS16545	COG0366	Alpha amylase catalytic
HXV88_RS16550	COG1013	pyruvate-flavodoxin oxidoreductase activity
HXV88_RS16550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_RS16550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HXV88_RS16550	COG0674	pyruvate-flavodoxin oxidoreductase activity
HXV88_RS16560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXV88_RS16575	COG1012	belongs to the aldehyde dehydrogenase family
HXV88_RS16585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HXV88_RS16590	COG0512	Glutamine amidotransferase of anthranilate synthase
HXV88_RS16600	COG0180	Tryptophanyl-tRNA synthetase
HXV88_RS16610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HXV88_RS16615	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HXV88_RS16625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HXV88_RS16630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HXV88_RS16660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HXV88_RS16665	COG0583	DNA-binding transcription factor activity
HXV88_RS16685	COG0583	DNA-binding transcription factor activity
HXV88_RS16695	COG0739	heme binding
HXV88_RS16705	COG1511	domain protein
HXV88_RS16705	COG3264	Mechanosensitive ion channel
HXV88_RS16710	COG0584	glycerophosphoryl diester phosphodiesterase
HXV88_RS16720	COG1053	succinate dehydrogenase
HXV88_RS16725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HXV88_RS16730	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HXV88_RS16735	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HXV88_RS16740	COG3366	ferrous iron transmembrane transporter activity
HXV88_RS16745	COG0700	Nucleoside recognition
HXV88_RS16750	COG2195	Cleaves the N-terminal amino acid of tripeptides
HXV88_RS16760	COG3214	Protein conserved in bacteria
HXV88_RS16775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_RS16780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_RS16800	COG1022	Amp-dependent synthetase and ligase
HXV88_RS16810	COG4221	oxidoreductase activity
HXV88_RS16825	COG0642	Histidine kinase
HXV88_RS16835	COG0516	GMP reductase activity
HXV88_RS16845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HXV88_RS16855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HXV88_RS16865	COG3447	MASE1 domain protein
HXV88_RS16865	COG5001	Diguanylate cyclase
HXV88_RS16865	COG5002	protein histidine kinase activity
HXV88_RS16885	COG0583	DNA-binding transcription factor activity
HXV88_RS16890	COG3706	GGDEF domain
HXV88_RS16900	COG1335	isochorismatase
HXV88_RS16905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HXV88_RS16910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXV88_RS16915	COG1702	phosphate starvation-inducible protein PhoH
HXV88_RS16920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HXV88_RS16925	COG4535	Mg2 and Co2 transporter CorC
HXV88_RS16930	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HXV88_RS16935	COG0789	Transcriptional regulator
HXV88_RS16950	COG1970	mechanosensitive ion channel activity
HXV88_RS16955	COG4974	Belongs to the 'phage' integrase family
HXV88_RS16960	COG0716	FMN binding
HXV88_RS16965	COG0312	modulator of DNA gyrase
HXV88_RS16970	COG0312	modulator of DNA gyrase
HXV88_RS16975	COG2888	peptidyl-tyrosine sulfation
HXV88_RS16980	COG0495	leucyl-tRNA aminoacylation
HXV88_RS16995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HXV88_RS17000	COG0799	negative regulation of ribosome biogenesis
HXV88_RS17005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HXV88_RS17010	COG0768	penicillin binding
HXV88_RS17015	COG0772	Belongs to the SEDS family
HXV88_RS17020	COG2951	lytic endotransglycosylase activity
HXV88_RS17025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HXV88_RS17030	COG1686	Belongs to the peptidase S11 family
HXV88_RS17035	COG2921	Belongs to the UPF0250 family
HXV88_RS17040	COG0321	lipoyl(octanoyl) transferase activity
HXV88_RS17045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HXV88_RS17065	COG3139	Protein of unknown function (DUF1315)
HXV88_RS17070	COG0252	asparaginase activity
HXV88_RS17075	COG0786	glutamate:sodium symporter activity
HXV88_RS17090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HXV88_RS17095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HXV88_RS17100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HXV88_RS17115	COG3610	response to peptide
HXV88_RS17120	COG2966	Psort location CytoplasmicMembrane, score
HXV88_RS17130	COG0521	Mo-molybdopterin cofactor biosynthetic process
HXV88_RS17145	COG2897	thiosulfate sulfurtransferase activity
HXV88_RS17150	COG2066	Belongs to the glutaminase family
HXV88_RS17155	COG3171	Protein conserved in bacteria
HXV88_RS17160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HXV88_RS17165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXV88_RS17170	COG2200	EAL domain
HXV88_RS17175	COG1090	epimerase
HXV88_RS17180	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HXV88_RS17185	COG4181	ATPase activity
HXV88_RS17190	COG2755	lipolytic protein G-D-S-L family
HXV88_RS17195	COG0835	chemotaxis
HXV88_RS17195	COG0784	Response regulator, receiver
HXV88_RS17235	COG3397	chitin binding
HXV88_RS17250	COG3706	GGDEF domain
HXV88_RS17260	COG2205	protein histidine kinase activity
HXV88_RS17260	COG5002	protein histidine kinase activity
HXV88_RS17260	COG0784	Response regulator, receiver
HXV88_RS17270	COG3655	Transcriptional regulator
HXV88_RS17280	COG2814	Major facilitator Superfamily
HXV88_RS17300	COG3501	Rhs element vgr protein
HXV88_RS17335	COG0748	coenzyme F420 binding
HXV88_RS17340	COG3721	Heme iron utilization protein
HXV88_RS17350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXV88_RS17375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HXV88_RS17390	COG0737	Belongs to the 5'-nucleotidase family
HXV88_RS17410	COG2204	response regulator
HXV88_RS17415	COG0545	Peptidyl-prolyl cis-trans isomerase
HXV88_RS17425	COG2900	Belongs to the SlyX family
HXV88_RS17430	COG1047	Peptidyl-prolyl cis-trans
HXV88_RS17435	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HXV88_RS17445	COG0784	Response regulator, receiver
HXV88_RS17445	COG0835	chemotaxis
HXV88_RS17450	COG0429	hydrolase of the alpha beta-hydrolase fold
HXV88_RS17455	COG5001	Diguanylate cyclase
HXV88_RS17455	COG4251	negative regulation of phosphorylation
HXV88_RS17455	COG2203	Gaf domain
HXV88_RS17455	COG3706	GGDEF domain
HXV88_RS17460	COG3089	Belongs to the UPF0270 family
HXV88_RS17465	COG3954	Phosphoribulokinase
HXV88_RS17480	COG1765	OsmC-like protein
HXV88_RS17520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXV88_RS17525	COG2313	pseudouridylate synthase activity
HXV88_RS17560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXV88_RS17570	COG0318	PFAM AMP-dependent synthetase and ligase
HXV88_RS17575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXV88_RS17585	COG2986	histidine ammonia-lyase
HXV88_RS17610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXV88_RS17615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXV88_RS17620	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_RS17625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXV88_RS17635	COG0778	Nitroreductase
HXV88_RS17640	COG1902	pentaerythritol trinitrate reductase activity
HXV88_RS17640	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXV88_RS17645	COG0616	signal peptide processing
HXV88_RS17665	COG0848	biopolymer transport protein
HXV88_RS17670	COG0811	peptide transport
HXV88_RS17675	COG0811	peptide transport
HXV88_RS17690	COG4174	ABC transporter (Permease)
HXV88_RS17695	COG4239	(ABC) transporter, permease
HXV88_RS17705	COG0444	Belongs to the ABC transporter superfamily
HXV88_RS17710	COG4608	Belongs to the ABC transporter superfamily
HXV88_RS17730	COG3416	Protein conserved in bacteria
HXV88_RS17740	COG0741	lytic transglycosylase activity
HXV88_RS17755	COG0488	(ABC) transporter
HXV88_RS17765	COG2252	PERMEase
HXV88_RS17770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXV88_RS17775	COG0840	transmembrane signaling receptor activity
HXV88_RS17785	COG1278	Cold shock
HXV88_RS17825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HXV88_RS17830	COG1162	GTPase activity
HXV88_RS17835	COG0688	phosphatidylethanolamine metabolic process
HXV88_RS17840	COG4628	conserved protein (DUF2132)
HXV88_RS17860	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HXV88_RS17865	COG1381	Involved in DNA repair and RecF pathway recombination
HXV88_RS17880	COG0681	Belongs to the peptidase S26 family
HXV88_RS17885	COG0481	GTPase activity
HXV88_RS17895	COG3026	antisigma factor binding
HXV88_RS17900	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HXV88_RS17905	COG1595	DNA-templated transcription, initiation
HXV88_RS17910	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HXV88_RS17920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HXV88_RS17925	COG0354	folic acid binding
HXV88_RS17970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_RS17975	COG0191	fructose-bisphosphate aldolase activity
HXV88_RS17980	COG0126	phosphoglycerate kinase activity
HXV88_RS17985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HXV88_RS17990	COG1940	carbohydrate kinase activity
HXV88_RS17995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HXV88_RS18000	COG2816	NAD+ diphosphatase activity
HXV88_RS18010	COG4991	sh3 domain protein
HXV88_RS18015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HXV88_RS18030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HXV88_RS18065	COG2816	NAD+ diphosphatase activity
HXV88_RS18110	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HXV88_RS18120	COG2203	Gaf domain
HXV88_RS18120	COG2199	diguanylate cyclase activity
HXV88_RS18125	COG0513	Belongs to the DEAD box helicase family
HXV88_RS18155	COG0154	amidase activity
HXV88_RS18160	COG2957	Belongs to the agmatine deiminase family
HXV88_RS18175	COG1902	pentaerythritol trinitrate reductase activity
HXV88_RS18190	COG1238	metal cluster binding
HXV88_RS18195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HXV88_RS18200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HXV88_RS18205	COG0585	pseudouridine synthase activity
HXV88_RS18215	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HXV88_RS18220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HXV88_RS18225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXV88_RS18235	COG1376	ErfK ybiS ycfS ynhG family protein
HXV88_RS18240	COG0668	transmembrane transport
HXV88_RS18250	COG2731	YhcH YjgK YiaL family protein
HXV88_RS18260	COG1794	racemase activity, acting on amino acids and derivatives
HXV88_RS18275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXV88_RS18290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HXV88_RS18290	COG0617	tRNA 3'-terminal CCA addition
HXV88_RS18290	COG0517	IMP dehydrogenase activity
HXV88_RS18330	COG0488	(ABC) transporter
HXV88_RS18340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HXV88_RS18385	COG0148	phosphopyruvate hydratase activity
HXV88_RS18390	COG0504	CTP synthase activity
HXV88_RS18395	COG3956	TIGRFAM MazG family protein
HXV88_RS18400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HXV88_RS18405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXV88_RS18415	COG4807	Protein conserved in bacteria
HXV88_RS18420	COG3023	N-Acetylmuramoyl-L-alanine amidase
HXV88_RS18425	COG0783	Belongs to the Dps family
HXV88_RS18430	COG1151	hydroxylamine reductase activity
HXV88_RS18435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HXV88_RS18440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HXV88_RS18445	COG0671	phosphoesterase, PA-phosphatase related
HXV88_RS18450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HXV88_RS18455	COG0163	prenyltransferase activity
HXV88_RS18470	COG1131	(ABC) transporter
HXV88_RS18475	COG0842	Transport permease protein
HXV88_RS18505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HXV88_RS18510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HXV88_RS18515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HXV88_RS18525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXV88_RS18530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HXV88_RS18535	COG1489	DNA binding
HXV88_RS18545	COG1643	Atp-dependent helicase
HXV88_RS18550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXV88_RS18555	COG0346	lactoylglutathione lyase activity
HXV88_RS18560	COG2076	Multidrug Resistance protein
HXV88_RS18565	COG2076	Multidrug Resistance protein
HXV88_RS18575	COG0784	Response regulator, receiver
HXV88_RS18575	COG3437	response regulator, receiver
HXV88_RS18580	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HXV88_RS18595	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HXV88_RS18610	COG1136	(ABC) transporter
HXV88_RS18630	COG0840	transmembrane signaling receptor activity
HXV88_RS18640	COG0529	Catalyzes the synthesis of activated sulfate
HXV88_RS18645	COG3273	potassium ion transport
HXV88_RS18645	COG0471	metal ion transport
HXV88_RS18650	COG2895	sulfate adenylyltransferase (ATP) activity
HXV88_RS18655	COG0175	sulfate reduction
HXV88_RS18660	COG1648	precorrin-2 dehydrogenase activity
HXV88_RS18660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXV88_RS18665	COG0330	HflC and HflK could
HXV88_RS18670	COG1585	Membrane protein implicated in regulation of membrane protease activity
HXV88_RS18675	COG0840	transmembrane signaling receptor activity
HXV88_RS18680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HXV88_RS18685	COG0676	glucose-6-phosphate 1-epimerase activity
HXV88_RS18690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HXV88_RS18695	COG1640	4-alpha-glucanotransferase
HXV88_RS18700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HXV88_RS18750	COG0561	phosphatase activity
HXV88_RS18765	COG0733	neurotransmitter:sodium symporter activity
HXV88_RS18775	COG0733	neurotransmitter:sodium symporter activity
HXV88_RS18840	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HXV88_RS18845	COG2885	chlorophyll binding
HXV88_RS18850	COG0823	Involved in the tonB-independent uptake of proteins
HXV88_RS18865	COG0811	peptide transport
HXV88_RS18870	COG0824	Thioesterase
HXV88_RS18875	COG3790	cyd operon protein YbgE
HXV88_RS18880	COG4890	Cyd operon protein YbgT
HXV88_RS18885	COG1294	oxidase, subunit
HXV88_RS18895	COG2255	four-way junction helicase activity
HXV88_RS18900	COG0632	four-way junction helicase activity
HXV88_RS18905	COG0840	transmembrane signaling receptor activity
HXV88_RS18930	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HXV88_RS18935	COG2203	Gaf domain
HXV88_RS18935	COG3706	GGDEF domain
HXV88_RS18935	COG4251	negative regulation of phosphorylation
HXV88_RS18935	COG5001	Diguanylate cyclase
HXV88_RS18945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXV88_RS18955	COG2995	paraquat-inducible protein a
HXV88_RS18960	COG3008	intermembrane lipid transfer
HXV88_RS18960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HXV88_RS18965	COG3009	Protein conserved in bacteria
HXV88_RS18970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXV88_RS18975	COG0442	prolyl-tRNA aminoacylation
HXV88_RS18980	COG4221	oxidoreductase activity
HXV88_RS18995	COG1024	Enoyl-CoA hydratase
HXV88_RS19005	COG0110	maltose O-acetyltransferase activity
HXV88_RS19015	COG4166	transmembrane transport
HXV88_RS19025	COG0840	transmembrane signaling receptor activity
HXV88_RS19050	COG1017	nitric oxide dioxygenase activity
HXV88_RS19050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HXV88_RS19055	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HXV88_RS19060	COG0039	L-malate dehydrogenase activity
HXV88_RS19065	COG4160	amino acid transport
HXV88_RS19070	COG4215	(ABC) transporter
HXV88_RS19075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_RS19080	COG1126	abc transporter atp-binding protein
HXV88_RS19085	COG1438	arginine binding
HXV88_RS19090	COG2837	iron assimilation
HXV88_RS19095	COG3842	ATPase activity
HXV88_RS19105	COG1840	ABC-type Fe3 transport system, periplasmic component
HXV88_RS19110	COG0347	Belongs to the P(II) protein family
HXV88_RS19130	COG3022	response to hydroperoxide
HXV88_RS19145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HXV88_RS19150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HXV88_RS19155	COG0762	integral membrane protein
HXV88_RS19160	COG1872	DUF167
HXV88_RS19170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HXV88_RS19175	COG0583	DNA-binding transcription factor activity
HXV88_RS19195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HXV88_RS19200	COG0735	belongs to the Fur family
HXV88_RS19225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HXV88_RS19230	COG0513	Belongs to the DEAD box helicase family
HXV88_RS19235	COG2153	protein acetylation
HXV88_RS19245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HXV88_RS19250	COG0557	exoribonuclease II activity
HXV88_RS19255	COG3706	GGDEF domain
HXV88_RS19260	COG2885	chlorophyll binding
HXV88_RS19260	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HXV88_RS19265	COG3240	lipase activity
HXV88_RS19270	COG3111	PFAM Bacterial OB fold (BOF) protein
HXV88_RS19280	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HXV88_RS19285	COG1194	a g-specific adenine glycosylase
HXV88_RS19290	COG0617	tRNA 3'-terminal CCA addition
HXV88_RS19310	COG1929	Belongs to the glycerate kinase type-1 family
HXV88_RS19315	COG2610	gluconate transmembrane transporter activity
HXV88_RS19320	COG3835	regulator
HXV88_RS19325	COG3112	Uncharacterised protein family (UPF0231)
HXV88_RS19355	COG0513	Belongs to the DEAD box helicase family
HXV88_RS19395	COG1448	Aminotransferase
HXV88_RS19410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HXV88_RS19415	COG1328	CTP reductase activity
HXV88_RS19440	COG0633	Ferredoxin
HXV88_RS19440	COG0543	2 iron, 2 sulfur cluster binding
HXV88_RS19455	COG1215	transferase activity, transferring glycosyl groups
HXV88_RS19460	COG0726	polysaccharide deacetylase
HXV88_RS19460	COG1649	PFAM Uncharacterised BCR, COG1649
HXV88_RS19475	COG0840	transmembrane signaling receptor activity
HXV88_RS19480	COG3397	chitin binding
HXV88_RS19485	COG3174	membrane
HXV88_RS19490	COG0110	maltose O-acetyltransferase activity
HXV88_RS19505	COG1011	Hydrolase
HXV88_RS19510	COG0494	nUDIX hydrolase
HXV88_RS19515	COG1218	3'(2'),5'-bisphosphate nucleotidase
HXV88_RS19525	COG0814	amino acid
HXV88_RS19530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXV88_RS19545	COG0626	cystathionine gamma-synthase activity
HXV88_RS19550	COG0460	homoserine dehydrogenase
HXV88_RS19550	COG0527	aspartate kinase activity
HXV88_RS19555	COG0306	phosphate transporter
HXV88_RS19560	COG1392	Phosphate transport regulator
HXV88_RS19570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXV88_RS19575	COG2813	Specifically methylates the guanine in position
HXV88_RS19580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HXV88_RS19585	COG0297	glycogen (starch) synthase activity
HXV88_RS19625	COG1757	Na H antiporter
HXV88_RS19630	COG0316	Belongs to the HesB IscA family
HXV88_RS19640	COG0038	chloride channel
HXV88_RS19645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HXV88_RS19660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HXV88_RS19660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HXV88_RS19680	COG1204	response to ionizing radiation
HXV88_RS19735	COG2003	Belongs to the UPF0758 family
HXV88_RS19770	COG3311	Transcriptional regulator
HXV88_RS19795	COG3501	Rhs element vgr protein
HXV88_RS19830	COG0582	viral genome integration into host DNA
HXV88_RS19860	COG1396	sequence-specific DNA binding
HXV88_RS19865	COG3135	benzoate transporter
HXV88_RS19890	COG0840	transmembrane signaling receptor activity
HXV88_RS19895	COG3047	cAMP biosynthetic process
HXV88_RS19900	COG3706	GGDEF domain
HXV88_RS19905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HXV88_RS19940	COG2197	response regulator
HXV88_RS19955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HXV88_RS19965	COG1278	Cold shock
HXV88_RS19970	COG2252	PERMEase
HXV88_RS19975	COG2376	Dihydroxyacetone kinase
HXV88_RS19980	COG1461	Dihydroxyacetone kinase
HXV88_RS19985	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HXV88_RS19985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_RS19985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXV88_RS19995	COG3284	Transcriptional regulator
HXV88_RS20005	COG0628	permease
HXV88_RS20010	COG0494	nUDIX hydrolase
HXV88_RS20025	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HXV88_RS20050	COG0456	acetyltransferase
HXV88_RS20055	COG3133	Outer membrane lipoprotein
HXV88_RS20060	COG0004	ammonium transporteR
HXV88_RS20065	COG3706	GGDEF domain
HXV88_RS20075	COG3932	Exopolysaccharide synthesis, ExoD
HXV88_RS20080	COG0814	amino acid
HXV88_RS20085	COG3706	GGDEF domain
HXV88_RS20095	COG0110	maltose O-acetyltransferase activity
HXV88_RS20125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HXV88_RS20130	COG2022	thiamine diphosphate biosynthetic process
HXV88_RS20140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HXV88_RS20145	COG0352	thiamine-phosphate diphosphorylase activity
HXV88_RS20150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HXV88_RS20170	COG0745	RESPONSE REGULATOR receiver
HXV88_RS20175	COG0642	Histidine kinase
HXV88_RS20180	COG0189	ligase activity
HXV88_RS20230	COG0477	Major facilitator Superfamily
HXV88_RS20245	COG0312	modulator of DNA gyrase
HXV88_RS20250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HXV88_RS20260	COG3164	Protein of unknown function
HXV88_RS20265	COG1530	ribonuclease E activity
HXV88_RS20270	COG0424	maF-like protein
HXV88_RS20275	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HXV88_RS20280	COG1792	Involved in formation and maintenance of cell shape
HXV88_RS20285	COG1077	Cell shape determining protein MreB Mrl
HXV88_RS20330	COG1459	type II secretion system
HXV88_RS20335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HXV88_RS20380	COG2200	EAL domain
HXV88_RS20380	COG2199	diguanylate cyclase activity
HXV88_RS20385	COG2200	EAL domain
HXV88_RS20390	COG0387	Pfam Sodium calcium exchanger
HXV88_RS20395	COG2986	histidine ammonia-lyase
HXV88_RS20400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HXV88_RS20405	COG0010	Belongs to the arginase family
HXV88_RS20410	COG1228	amidohydrolase
HXV88_RS20415	COG2188	Transcriptional regulator
HXV88_RS20420	COG0288	reversible hydration of carbon dioxide
HXV88_RS20430	COG2177	Part of the ABC transporter FtsEX involved in
HXV88_RS20435	COG2884	Cell division ATP-binding protein ftsE
HXV88_RS20440	COG0552	protein localization to endoplasmic reticulum
HXV88_RS20445	COG0742	ribosomal rna small subunit methyltransferase
HXV88_RS20470	COG2249	NAD(P)H dehydrogenase (quinone) activity
HXV88_RS20475	COG0583	DNA-binding transcription factor activity
HXV88_RS20480	COG4221	oxidoreductase activity
HXV88_RS20495	COG1770	oligopeptidase
HXV88_RS20510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HXV88_RS20520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HXV88_RS20530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HXV88_RS20540	COG2095	MarC family integral membrane protein
HXV88_RS20550	COG1301	dicarboxylic acid transport
HXV88_RS20575	COG3714	YhhN family
HXV88_RS20630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HXV88_RS20635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HXV88_RS20640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HXV88_RS20645	COG0049	tRNA binding
HXV88_RS20650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HXV88_RS20655	COG2168	tRNA wobble position uridine thiolation
HXV88_RS20660	COG2923	Belongs to the DsrF TusC family
HXV88_RS20665	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HXV88_RS20675	COG2964	Protein conserved in bacteria
HXV88_RS20680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HXV88_RS20685	COG0085	RNA polymerase activity
HXV88_RS20690	COG0222	ribosome binding
HXV88_RS20695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HXV88_RS20700	COG0081	regulation of translation
HXV88_RS20705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HXV88_RS20710	COG0250	Participates in transcription elongation, termination and antitermination
HXV88_RS20725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HXV88_RS20750	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HXV88_RS20755	COG0569	domain protein
HXV88_RS20760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HXV88_RS20790	COG4191	Histidine kinase
HXV88_RS20790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_RS20795	COG3005	denitrification pathway
HXV88_RS20800	COG0243	molybdopterin cofactor binding
HXV88_RS20810	COG2205	protein histidine kinase activity
HXV88_RS20815	COG0745	RESPONSE REGULATOR receiver
HXV88_RS20845	COG2204	response regulator
HXV88_RS20855	COG2205	protein histidine kinase activity
HXV88_RS20870	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_RS20875	COG0516	GMP reductase activity
HXV88_RS20875	COG0517	IMP dehydrogenase activity
HXV88_RS20880	COG5413	integral membrane protein
HXV88_RS20890	COG1522	sequence-specific DNA binding
HXV88_RS20895	COG2502	aspartate--ammonia ligase
HXV88_RS20900	COG0542	response to heat
HXV88_RS20910	COG0564	pseudouridine synthase activity
HXV88_RS20915	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HXV88_RS20920	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXV88_RS20930	COG3681	Belongs to the UPF0597 family
HXV88_RS20935	COG2964	Protein conserved in bacteria
HXV88_RS20945	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HXV88_RS20950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HXV88_RS20955	COG1979	alcohol dehydrogenase
HXV88_RS20960	COG2207	Transcriptional regulator
HXV88_RS20965	COG3040	lipid binding
HXV88_RS20980	COG0583	DNA-binding transcription factor activity
HXV88_RS21000	COG0540	Belongs to the ATCase OTCase family
HXV88_RS21005	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HXV88_RS21010	COG1438	arginine binding
HXV88_RS21015	COG1288	antiporter activity
HXV88_RS21020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HXV88_RS21050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HXV88_RS21060	COG3078	GTPase activator activity
HXV88_RS21070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HXV88_RS21080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HXV88_RS21085	COG0408	coproporphyrinogen oxidase activity
HXV88_RS21090	COG0009	L-threonylcarbamoyladenylate synthase
HXV88_RS21100	COG0551	DNA topoisomerase type I activity
HXV88_RS21105	COG2922	Belongs to the Smg family
HXV88_RS21110	COG0758	DNA mediated transformation
HXV88_RS21115	COG1652	LysM domain
HXV88_RS21120	COG0242	peptide deformylase activity
HXV88_RS21125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HXV88_RS21130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HXV88_RS21130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HXV88_RS21135	COG0569	domain protein
HXV88_RS21140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HXV88_RS21150	COG0174	glutamine synthetase
HXV88_RS21165	COG2204	response regulator
HXV88_RS21170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HXV88_RS21175	COG1322	Protein conserved in bacteria
HXV88_RS21195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXV88_RS21200	COG0583	DNA-binding transcription factor activity
HXV88_RS21205	COG0519	Catalyzes the synthesis of GMP from XMP
HXV88_RS21205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HXV88_RS21220	COG1396	sequence-specific DNA binding
HXV88_RS21225	COG1012	belongs to the aldehyde dehydrogenase family
HXV88_RS21235	COG2962	Rard protein
HXV88_RS21240	COG0840	transmembrane signaling receptor activity
HXV88_RS21245	COG2391	methyltransferase activity
HXV88_RS21260	COG0129	dihydroxy-acid dehydratase activity
HXV88_RS21270	COG3978	acetolactate synthase activity
HXV88_RS21280	COG0606	chelatase, subunit chli
HXV88_RS21285	COG0204	Acyl-transferase
HXV88_RS21290	COG0204	Acyl-transferase
HXV88_RS21295	COG1683	Conserved Protein
HXV88_RS21305	COG1335	isochorismatase
HXV88_RS21315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HXV88_RS21320	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HXV88_RS21330	COG3084	Protein conserved in bacteria
HXV88_RS21335	COG4251	negative regulation of phosphorylation
HXV88_RS21335	COG3706	GGDEF domain
HXV88_RS21335	COG5001	Diguanylate cyclase
HXV88_RS21335	COG2203	Gaf domain
HXV88_RS21350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HXV88_RS21355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HXV88_RS21360	COG1561	YicC-like family, N-terminal region
HXV88_RS21365	COG0583	DNA-binding transcription factor activity
HXV88_RS21380	COG0583	DNA-binding transcription factor activity
HXV88_RS21420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HXV88_RS21425	COG0385	Bile acid
HXV88_RS21430	COG0531	amino acid
HXV88_RS21435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXV88_RS21440	COG0531	amino acid
HXV88_RS21445	COG2731	YhcH YjgK YiaL family protein
HXV88_RS21450	COG3250	beta-galactosidase activity
HXV88_RS21455	COG1609	Transcriptional regulator
HXV88_RS21490	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HXV88_RS21495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXV88_RS21495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXV88_RS21500	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HXV88_RS21505	COG3074	FtsZ-dependent cytokinesis
HXV88_RS21515	COG1045	serine acetyltransferase
HXV88_RS21525	COG0745	RESPONSE REGULATOR receiver
HXV88_RS21530	COG2205	protein histidine kinase activity
HXV88_RS21535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HXV88_RS21540	COG0534	Mate efflux family protein
HXV88_RS21555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HXV88_RS21560	COG2937	Belongs to the GPAT DAPAT family
HXV88_RS21565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HXV88_RS21570	COG3161	chorismate lyase activity
HXV88_RS21590	COG0604	alcohol dehydrogenase
HXV88_RS21595	COG1609	Transcriptional regulator
HXV88_RS21600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_RS21615	COG1519	Transferase
HXV88_RS21620	COG0859	PFAM glycosyl transferase family 9
HXV88_RS21625	COG0463	Glycosyl transferase, family 2
HXV88_RS21630	COG0859	PFAM glycosyl transferase family 9
HXV88_RS21635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HXV88_RS21640	COG2990	Protein conserved in bacteria
HXV88_RS21645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HXV88_RS21655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HXV88_RS21660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HXV88_RS21665	COG2003	Belongs to the UPF0758 family
HXV88_RS21670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HXV88_RS21680	COG4974	Belongs to the 'phage' integrase family
HXV88_RS21700	COG1278	Cold shock
HXV88_RS21710	COG5642	Protein of unknown function (DUF2384)
HXV88_RS21725	COG2916	Histone family protein nucleoid-structuring protein H-NS
HXV88_RS21755	COG0756	dUTP diphosphatase activity
HXV88_RS21765	COG1309	transcriptional regulator
HXV88_RS21770	COG0668	transmembrane transport
HXV88_RS21775	COG0166	Belongs to the GPI family
HXV88_RS21780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HXV88_RS21800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXV88_RS21800	COG1042	CoA-binding domain protein
HXV88_RS21800	COG0045	succinate-CoA ligase (ADP-forming) activity
HXV88_RS21830	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HXV88_RS21835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HXV88_RS21840	COG1739	Uncharacterized protein family UPF0029
HXV88_RS21845	COG0006	proline dipeptidase activity
HXV88_RS21850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HXV88_RS21855	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXV88_RS21855	COG1024	Enoyl-CoA hydratase
HXV88_RS21860	COG0183	Belongs to the thiolase family
HXV88_RS21865	COG0745	RESPONSE REGULATOR receiver
HXV88_RS21870	COG2205	protein histidine kinase activity
HXV88_RS21885	COG0425	Belongs to the sulfur carrier protein TusA family
HXV88_RS21890	COG0251	oxidation-reduction process
HXV88_RS21895	COG2885	chlorophyll binding
HXV88_RS21900	COG2818	Glycosylase
HXV88_RS21905	COG0752	glycyl-tRNA synthetase alpha subunit
HXV88_RS21910	COG0751	glycine-tRNA ligase activity
HXV88_RS21955	COG2188	Transcriptional regulator
HXV88_RS21970	COG1609	Transcriptional regulator
HXV88_RS22000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXV88_RS22010	COG2960	long-chain fatty acid transporting porin activity
HXV88_RS22015	COG5001	Diguanylate cyclase
HXV88_RS22025	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HXV88_RS22040	COG3118	belongs to the thioredoxin family
HXV88_RS22045	COG0513	Belongs to the DEAD box helicase family
HXV88_RS22050	COG0248	Ppx GppA phosphatase
HXV88_RS22060	COG0742	ribosomal rna small subunit methyltransferase
HXV88_RS22080	COG3469	chitinase activity
HXV88_RS22085	COG3397	chitin binding
HXV88_RS22095	COG0084	hydrolase, TatD family'
HXV88_RS22100	COG0805	protein transport
HXV88_RS22105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HXV88_RS22110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HXV88_RS22115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HXV88_RS22120	COG3165	ubiquinone biosynthetic process from chorismate
HXV88_RS22125	COG2226	methyltransferase
HXV88_RS22130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HXV88_RS22135	COG0402	S-adenosylhomocysteine deaminase activity
HXV88_RS22140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HXV88_RS22185	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HXV88_RS22190	COG0848	biopolymer transport protein
HXV88_RS22195	COG0811	peptide transport
HXV88_RS22200	COG0811	peptide transport
HXV88_RS22210	COG2771	luxR family
HXV88_RS22215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HXV88_RS22220	COG1349	DNA-binding transcription factor activity
HXV88_RS22225	COG0745	RESPONSE REGULATOR receiver
HXV88_RS22230	COG2205	protein histidine kinase activity
HXV88_RS22245	COG4452	Inner membrane protein CreD
HXV88_RS22260	COG0297	glycogen (starch) synthase activity
HXV88_RS22260	COG0438	transferase activity, transferring glycosyl groups
HXV88_RS22305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXV88_RS22310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HXV88_RS22315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HXV88_RS22320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HXV88_RS22325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HXV88_RS22330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HXV88_RS22335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HXV88_RS22340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HXV88_RS22350	COG0356	it plays a direct role in the translocation of protons across the membrane
HXV88_RS22360	COG1475	DNA binding
HXV88_RS22365	COG1192	Involved in chromosome partitioning
HXV88_RS22370	COG0357	Ribosomal RNA small subunit methyltransferase G
HXV88_RS22375	COG0445	tRNA wobble uridine modification
HXV88_RS22380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HXV88_RS22390	COG4615	Cyclic peptide transporter
HXV88_RS22395	COG1120	ATPase activity
HXV88_RS22400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXV88_RS22405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXV88_RS22410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HXV88_RS22415	COG0706	membrane insertase activity
HXV88_RS22420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HXV88_RS22425	COG0594	ribonuclease P activity
HXV88_RS22430	COG0230	Belongs to the bacterial ribosomal protein bL34 family