locus-tag	class	description
EFI48_RS00005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EFI48_RS00010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EFI48_RS00015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EFI48_RS00020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EFI48_RS00025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EFI48_RS00030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EFI48_RS00075	COG0438	transferase activity, transferring glycosyl groups
EFI48_RS00075	COG0297	glycogen (starch) synthase activity
EFI48_RS00090	COG4452	Inner membrane protein CreD
EFI48_RS00105	COG2205	protein histidine kinase activity
EFI48_RS00110	COG0745	RESPONSE REGULATOR receiver
EFI48_RS00115	COG1349	DNA-binding transcription factor activity
EFI48_RS00120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EFI48_RS00125	COG2771	luxR family
EFI48_RS00135	COG0811	peptide transport
EFI48_RS00140	COG0811	peptide transport
EFI48_RS00145	COG0848	biopolymer transport protein
EFI48_RS00150	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EFI48_RS00185	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EFI48_RS00190	COG0402	S-adenosylhomocysteine deaminase activity
EFI48_RS00195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EFI48_RS00200	COG2226	methyltransferase
EFI48_RS00205	COG3165	ubiquinone biosynthetic process from chorismate
EFI48_RS00210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EFI48_RS00215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EFI48_RS00220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EFI48_RS00225	COG0805	protein transport
EFI48_RS00230	COG0084	hydrolase, TatD family'
EFI48_RS00240	COG3397	chitin binding
EFI48_RS00245	COG3469	chitinase activity
EFI48_RS00260	COG0742	ribosomal rna small subunit methyltransferase
EFI48_RS00270	COG0248	Ppx GppA phosphatase
EFI48_RS00275	COG0513	Belongs to the DEAD box helicase family
EFI48_RS00280	COG3118	belongs to the thioredoxin family
EFI48_RS00295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EFI48_RS00305	COG5002	protein histidine kinase activity
EFI48_RS00305	COG5001	Diguanylate cyclase
EFI48_RS00310	COG2960	long-chain fatty acid transporting porin activity
EFI48_RS00325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EFI48_RS00355	COG1609	Transcriptional regulator
EFI48_RS00370	COG2188	Transcriptional regulator
EFI48_RS00410	COG0751	glycine-tRNA ligase activity
EFI48_RS00415	COG0752	glycyl-tRNA synthetase alpha subunit
EFI48_RS00420	COG2818	Glycosylase
EFI48_RS00425	COG2885	chlorophyll binding
EFI48_RS00430	COG0251	oxidation-reduction process
EFI48_RS00435	COG0425	Belongs to the sulfur carrier protein TusA family
EFI48_RS00460	COG0183	Belongs to the thiolase family
EFI48_RS00465	COG1250	3-hydroxyacyl-CoA dehydrogenase
EFI48_RS00465	COG1024	Enoyl-CoA hydratase
EFI48_RS00470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EFI48_RS00475	COG0006	proline dipeptidase activity
EFI48_RS00480	COG1739	Uncharacterized protein family UPF0029
EFI48_RS00485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EFI48_RS00490	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EFI48_RS00525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EFI48_RS00530	COG2166	iron-sulfur cluster assembly
EFI48_RS00535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EFI48_RS00550	COG3245	cytochrome
EFI48_RS00555	COG1063	alcohol dehydrogenase
EFI48_RS00570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EFI48_RS00615	COG1280	lysine exporter protein (LysE YggA)
EFI48_RS00655	COG1943	Transposase
EFI48_RS00660	COG0210	DNA helicase
EFI48_RS00665	COG1744	ABC transporter substrate-binding protein PnrA-like
EFI48_RS00670	COG3845	ABC transporter
EFI48_RS00675	COG4603	Belongs to the binding-protein-dependent transport system permease family
EFI48_RS00680	COG1079	Belongs to the binding-protein-dependent transport system permease family
EFI48_RS00690	COG0737	Belongs to the 5'-nucleotidase family
EFI48_RS00700	COG2239	Acts as a magnesium transporter
EFI48_RS00705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EFI48_RS00705	COG1648	precorrin-2 dehydrogenase activity
EFI48_RS00710	COG2116	formate transmembrane transporter activity
EFI48_RS00720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EFI48_RS00725	COG0842	Transport permease protein
EFI48_RS00730	COG0842	Transport permease protein
EFI48_RS00735	COG1131	(ABC) transporter
EFI48_RS00740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EFI48_RS00750	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EFI48_RS00755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EFI48_RS00765	COG0018	arginyl-trna synthetase
EFI48_RS00775	COG1595	DNA-templated transcription, initiation
EFI48_RS00785	COG1968	undecaprenyl-diphosphatase activity
EFI48_RS00790	COG2017	converts alpha-aldose to the beta-anomer
EFI48_RS00795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EFI48_RS00800	COG1085	galactose-1-phosphate uridylyltransferase
EFI48_RS00805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EFI48_RS00810	COG1609	Transcriptional regulator
EFI48_RS00815	COG3250	beta-galactosidase activity
EFI48_RS00825	COG1129	ABC transporter
EFI48_RS00830	COG4211	Belongs to the binding-protein-dependent transport system permease family
EFI48_RS00840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EFI48_RS00855	COG0366	Alpha amylase catalytic
EFI48_RS00870	COG0443	Heat shock 70 kDa protein
EFI48_RS00875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EFI48_RS00880	COG3045	CreA protein
EFI48_RS00900	COG0174	glutamine synthetase
EFI48_RS00920	COG3842	ATPase activity
EFI48_RS00925	COG1176	ABC-type spermidine putrescine transport system, permease component I
EFI48_RS00930	COG1177	transmembrane transport
EFI48_RS00935	COG2258	MOSC domain
EFI48_RS00950	COG2050	protein possibly involved in aromatic compounds catabolism
EFI48_RS00955	COG0514	ATP-dependent DNA helicase (RecQ)
EFI48_RS00965	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EFI48_RS00975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EFI48_RS00980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EFI48_RS01000	COG0254	rRNA binding
EFI48_RS01005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EFI48_RS01015	COG0702	epimerase
EFI48_RS01020	COG0814	amino acid
EFI48_RS01025	COG0281	malic enzyme
EFI48_RS01030	COG1295	ribonuclease BN
EFI48_RS01035	COG1490	D-aminoacyl-tRNA deacylase activity
EFI48_RS01045	COG0456	acetyltransferase
EFI48_RS01055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EFI48_RS01060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EFI48_RS01065	COG2610	gluconate transmembrane transporter activity
EFI48_RS01070	COG3265	gluconokinase activity
EFI48_RS01075	COG0129	dihydroxy-acid dehydratase activity
EFI48_RS01080	COG0800	Aldolase
EFI48_RS01085	COG1609	Transcriptional regulator
EFI48_RS01095	COG4942	peptidase
EFI48_RS01100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EFI48_RS01105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EFI48_RS01110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EFI48_RS01115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EFI48_RS01120	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EFI48_RS01120	COG0316	Belongs to the HesB IscA family
EFI48_RS01125	COG1040	competence protein
EFI48_RS01130	COG0596	Alpha beta hydrolase
EFI48_RS01150	COG2183	response to ionizing radiation
EFI48_RS01155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EFI48_RS01175	COG0051	transcription antitermination factor activity, RNA binding
EFI48_RS01180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EFI48_RS01185	COG0088	Forms part of the polypeptide exit tunnel
EFI48_RS01190	COG0089	rRNA binding
EFI48_RS01195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EFI48_RS01200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EFI48_RS01205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EFI48_RS01210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EFI48_RS01215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EFI48_RS01220	COG0255	Belongs to the universal ribosomal protein uL29 family
EFI48_RS01225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EFI48_RS01230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EFI48_RS01235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EFI48_RS01240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EFI48_RS01245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EFI48_RS01250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EFI48_RS01255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EFI48_RS01260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EFI48_RS01265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EFI48_RS01270	COG1841	ribosomal large subunit assembly
EFI48_RS01275	COG0200	Binds to the 23S rRNA
EFI48_RS01280	COG0201	protein transport
EFI48_RS01285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EFI48_RS01290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EFI48_RS01295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EFI48_RS01300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EFI48_RS01305	COG0202	RNA polymerase activity
EFI48_RS01310	COG0203	ribosomal protein L17
EFI48_RS01350	COG4771	TonB-dependent receptor
EFI48_RS01355	COG3706	GGDEF domain
EFI48_RS01380	COG0583	DNA-binding transcription factor activity
EFI48_RS01390	COG1741	Belongs to the pirin family
EFI48_RS01395	COG2259	Doxx family
EFI48_RS01400	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EFI48_RS01405	COG1074	ATP-dependent DNA helicase activity
EFI48_RS01410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EFI48_RS01450	COG1175	transmembrane transport
EFI48_RS01460	COG3842	ATPase activity
EFI48_RS01490	COG2873	o-acetylhomoserine
EFI48_RS01500	COG4533	DNA binding
EFI48_RS01520	COG5380	lipid catabolic process
EFI48_RS01525	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EFI48_RS01530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EFI48_RS01555	COG0753	catalase activity
EFI48_RS01560	COG0454	-acetyltransferase
EFI48_RS01560	COG0456	acetyltransferase
EFI48_RS01585	COG2927	DNA polymerase III (CHI subunit)
EFI48_RS01590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EFI48_RS01595	COG0795	lipopolysaccharide-transporting ATPase activity
EFI48_RS01600	COG0795	lipopolysaccharide-transporting ATPase activity
EFI48_RS01615	COG0582	viral genome integration into host DNA
EFI48_RS01730	COG1494	fructose-1,6-bisphosphatase
EFI48_RS01745	COG2959	enzyme of heme biosynthesis
EFI48_RS01755	COG0181	hydroxymethylbilane synthase activity
EFI48_RS01760	COG3072	Adenylate cyclase
EFI48_RS01765	COG0400	carboxylic ester hydrolase activity
EFI48_RS01770	COG1965	Belongs to the frataxin family
EFI48_RS01780	COG0019	diaminopimelate decarboxylase activity
EFI48_RS01785	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EFI48_RS01800	COG1011	Hydrolase
EFI48_RS01820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EFI48_RS01825	COG3028	Belongs to the UPF0307 family
EFI48_RS01830	COG0312	modulator of DNA gyrase
EFI48_RS01840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EFI48_RS01845	COG5007	Belongs to the BolA IbaG family
EFI48_RS01855	COG2854	intermembrane phospholipid transfer
EFI48_RS01860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EFI48_RS01865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EFI48_RS01870	COG1127	ABC transporter
EFI48_RS01875	COG0517	IMP dehydrogenase activity
EFI48_RS01875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EFI48_RS01880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EFI48_RS01885	COG3117	lipopolysaccharide transmembrane transporter activity
EFI48_RS01890	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EFI48_RS01895	COG1137	ATPase activity
EFI48_RS01910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFI48_RS01915	COG1660	Displays ATPase and GTPase activities
EFI48_RS01920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFI48_RS01925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFI48_RS01925	COG3711	transcriptional antiterminator
EFI48_RS01940	COG3964	amidohydrolase
EFI48_RS01970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EFI48_RS01975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EFI48_RS01985	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EFI48_RS01990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EFI48_RS01995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EFI48_RS02000	COG0723	plastoquinol--plastocyanin reductase activity
EFI48_RS02005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EFI48_RS02010	COG2857	Cytochrome c1
EFI48_RS02015	COG0625	glutathione transferase activity
EFI48_RS02020	COG2969	positive regulation of protein catabolic process
EFI48_RS02030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EFI48_RS02035	COG0792	nuclease activity
EFI48_RS02040	COG3107	peptidoglycan biosynthetic process
EFI48_RS02045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EFI48_RS02055	COG2001	Belongs to the MraZ family
EFI48_RS02060	COG0275	rRNA processing
EFI48_RS02065	COG3116	cell division
EFI48_RS02070	COG0768	penicillin binding
EFI48_RS02080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EFI48_RS02085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EFI48_RS02090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EFI48_RS02095	COG0772	Belongs to the SEDS family
EFI48_RS02100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EFI48_RS02105	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EFI48_RS02115	COG0849	cell division
EFI48_RS02120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EFI48_RS02125	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EFI48_RS02135	COG0653	protein targeting
EFI48_RS02140	COG0494	nUDIX hydrolase
EFI48_RS02145	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EFI48_RS02150	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EFI48_RS02160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EFI48_RS02165	COG1459	type II secretion system
EFI48_RS02170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EFI48_RS02200	COG2186	Transcriptional regulator
EFI48_RS02205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EFI48_RS02210	COG0508	dehydrogenase complex catalyzes the overall conversion of
EFI48_RS02215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EFI48_RS02225	COG0840	transmembrane signaling receptor activity
EFI48_RS02230	COG1752	Esterase of the alpha-beta hydrolase superfamily
EFI48_RS02235	COG1049	propionate catabolic process, 2-methylcitrate cycle
EFI48_RS02240	COG2200	EAL domain
EFI48_RS02250	COG0523	cobalamin synthesis protein
EFI48_RS02255	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EFI48_RS02270	COG2814	Major facilitator Superfamily
EFI48_RS02285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EFI48_RS02290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EFI48_RS02315	COG3314	Sporulation integral membrane protein YlbJ
EFI48_RS02335	COG0165	Argininosuccinate lyase
EFI48_RS02340	COG0137	argininosuccinate synthase activity
EFI48_RS02350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EFI48_RS02355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EFI48_RS02365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EFI48_RS02370	COG0110	maltose O-acetyltransferase activity
EFI48_RS02380	COG3706	GGDEF domain
EFI48_RS02385	COG0814	amino acid
EFI48_RS02390	COG3932	Exopolysaccharide synthesis, ExoD
EFI48_RS02400	COG3706	GGDEF domain
EFI48_RS02405	COG0004	ammonium transporteR
EFI48_RS02410	COG3133	Outer membrane lipoprotein
EFI48_RS02415	COG0456	acetyltransferase
EFI48_RS02435	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EFI48_RS02440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EFI48_RS02455	COG0494	nUDIX hydrolase
EFI48_RS02460	COG0628	permease
EFI48_RS02465	COG5433	transposase activity
EFI48_RS02490	COG3284	Transcriptional regulator
EFI48_RS02500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFI48_RS02500	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EFI48_RS02500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EFI48_RS02505	COG1461	Dihydroxyacetone kinase
EFI48_RS02510	COG2376	Dihydroxyacetone kinase
EFI48_RS02515	COG2252	PERMEase
EFI48_RS02520	COG1278	Cold shock
EFI48_RS02550	COG1396	sequence-specific DNA binding
EFI48_RS02595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EFI48_RS02635	COG2197	response regulator
EFI48_RS02670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EFI48_RS02680	COG3047	cAMP biosynthetic process
EFI48_RS02685	COG0840	transmembrane signaling receptor activity
EFI48_RS02710	COG3135	benzoate transporter
EFI48_RS02715	COG1396	sequence-specific DNA binding
EFI48_RS02750	COG2926	Belongs to the UPF0265 family
EFI48_RS02760	COG0561	phosphatase activity
EFI48_RS02770	COG1058	Belongs to the CinA family
EFI48_RS02770	COG1546	Belongs to the CinA family
EFI48_RS02780	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EFI48_RS02790	COG1522	sequence-specific DNA binding
EFI48_RS02795	COG1368	sulfuric ester hydrolase activity
EFI48_RS02830	COG4221	oxidoreductase activity
EFI48_RS02845	COG1979	alcohol dehydrogenase
EFI48_RS02850	COG1803	Methylglyoxal synthase
EFI48_RS02870	COG1444	tRNA N-acetyltransferase activity
EFI48_RS02875	COG1028	Short-chain dehydrogenase reductase Sdr
EFI48_RS02880	COG0835	chemotaxis
EFI48_RS02880	COG0784	Response regulator, receiver
EFI48_RS02890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EFI48_RS02895	COG2949	membrane
EFI48_RS02900	COG3291	Pkd domain containing protein
EFI48_RS02905	COG0318	PFAM AMP-dependent synthetase and ligase
EFI48_RS02910	COG1441	menaquinone biosynthetic process
EFI48_RS02915	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EFI48_RS02920	COG0596	Alpha beta hydrolase
EFI48_RS02925	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EFI48_RS02930	COG1169	isochorismate synthase
EFI48_RS02935	COG1575	Belongs to the MenA family. Type 1 subfamily
EFI48_RS02955	COG0513	Belongs to the DEAD box helicase family
EFI48_RS02960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EFI48_RS02965	COG1988	membrane-bound metal-dependent
EFI48_RS02970	COG1671	Belongs to the UPF0178 family
EFI48_RS02990	COG0484	heat shock protein binding
EFI48_RS03000	COG3722	fumarate hydratase activity
EFI48_RS03005	COG0246	Mannitol dehydrogenase
EFI48_RS03010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFI48_RS03010	COG2213	PTS system mannitol-specific
EFI48_RS03015	COG1560	Kdo2-lipid A biosynthetic process
EFI48_RS03020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EFI48_RS03020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EFI48_RS03025	COG1538	Outer membrane efflux protein
EFI48_RS03030	COG0494	nUDIX hydrolase
EFI48_RS03035	COG3151	Protein conserved in bacteria
EFI48_RS03045	COG3150	esterase
EFI48_RS03065	COG3104	oligopeptide transport
EFI48_RS03095	COG2084	Dehydrogenase
EFI48_RS03100	COG0583	DNA-binding transcription factor activity
EFI48_RS03105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EFI48_RS03125	COG0204	Acyl-transferase
EFI48_RS03130	COG1842	Phage shock protein A
EFI48_RS03145	COG2827	Endonuclease containing a URI domain
EFI48_RS03160	COG1573	uracil-dna glycosylase
EFI48_RS03170	COG0583	DNA-binding transcription factor activity
EFI48_RS03175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EFI48_RS03180	COG1121	(ABC) transporter
EFI48_RS03185	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EFI48_RS03205	COG0739	heme binding
EFI48_RS03215	COG3068	Protein conserved in bacteria
EFI48_RS03235	COG0617	tRNA 3'-terminal CCA addition
EFI48_RS03240	COG1194	a g-specific adenine glycosylase
EFI48_RS03245	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EFI48_RS03255	COG3111	PFAM Bacterial OB fold (BOF) protein
EFI48_RS03260	COG3240	lipase activity
EFI48_RS03265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EFI48_RS03265	COG2885	chlorophyll binding
EFI48_RS03270	COG3706	GGDEF domain
EFI48_RS03275	COG0557	exoribonuclease II activity
EFI48_RS03290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EFI48_RS03300	COG2153	protein acetylation
EFI48_RS03305	COG0513	Belongs to the DEAD box helicase family
EFI48_RS03310	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EFI48_RS03335	COG0735	belongs to the Fur family
EFI48_RS03340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EFI48_RS03345	COG0840	transmembrane signaling receptor activity
EFI48_RS03355	COG4166	transmembrane transport
EFI48_RS03365	COG0110	maltose O-acetyltransferase activity
EFI48_RS03375	COG1024	Enoyl-CoA hydratase
EFI48_RS03390	COG4221	oxidoreductase activity
EFI48_RS03395	COG0442	prolyl-tRNA aminoacylation
EFI48_RS03400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EFI48_RS03410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EFI48_RS03410	COG3008	intermembrane lipid transfer
EFI48_RS03415	COG2995	paraquat-inducible protein a
EFI48_RS03425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EFI48_RS03435	COG2203	Gaf domain
EFI48_RS03435	COG4251	negative regulation of phosphorylation
EFI48_RS03435	COG3706	GGDEF domain
EFI48_RS03435	COG5001	Diguanylate cyclase
EFI48_RS03440	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EFI48_RS03450	COG3916	Acyl-homoserine-lactone synthase
EFI48_RS03455	COG2771	luxR family
EFI48_RS03465	COG0840	transmembrane signaling receptor activity
EFI48_RS03470	COG0632	four-way junction helicase activity
EFI48_RS03475	COG2255	four-way junction helicase activity
EFI48_RS03485	COG1294	oxidase, subunit
EFI48_RS03490	COG4890	Cyd operon protein YbgT
EFI48_RS03495	COG3790	cyd operon protein YbgE
EFI48_RS03500	COG0824	Thioesterase
EFI48_RS03505	COG0811	peptide transport
EFI48_RS03520	COG0823	Involved in the tonB-independent uptake of proteins
EFI48_RS03525	COG2885	chlorophyll binding
EFI48_RS03530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EFI48_RS03600	COG0733	neurotransmitter:sodium symporter activity
EFI48_RS03610	COG0733	neurotransmitter:sodium symporter activity
EFI48_RS03625	COG0561	phosphatase activity
EFI48_RS03670	COG5433	transposase activity
EFI48_RS03680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EFI48_RS03685	COG1640	4-alpha-glucanotransferase
EFI48_RS03690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EFI48_RS03695	COG0676	glucose-6-phosphate 1-epimerase activity
EFI48_RS03700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EFI48_RS03705	COG0840	transmembrane signaling receptor activity
EFI48_RS03710	COG1585	Membrane protein implicated in regulation of membrane protease activity
EFI48_RS03715	COG0330	HflC and HflK could
EFI48_RS03720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EFI48_RS03720	COG1648	precorrin-2 dehydrogenase activity
EFI48_RS03725	COG0175	sulfate reduction
EFI48_RS03730	COG2895	sulfate adenylyltransferase (ATP) activity
EFI48_RS03735	COG3273	potassium ion transport
EFI48_RS03735	COG0471	metal ion transport
EFI48_RS03740	COG0529	Catalyzes the synthesis of activated sulfate
EFI48_RS03755	COG0840	transmembrane signaling receptor activity
EFI48_RS03775	COG1136	(ABC) transporter
EFI48_RS03790	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EFI48_RS03805	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EFI48_RS03810	COG3437	response regulator, receiver
EFI48_RS03810	COG0784	Response regulator, receiver
EFI48_RS03820	COG2076	Multidrug Resistance protein
EFI48_RS03825	COG2076	Multidrug Resistance protein
EFI48_RS03830	COG0346	lactoylglutathione lyase activity
EFI48_RS03835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EFI48_RS03840	COG1643	Atp-dependent helicase
EFI48_RS03850	COG1489	DNA binding
EFI48_RS03855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EFI48_RS03860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EFI48_RS03870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EFI48_RS03875	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EFI48_RS03880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EFI48_RS03890	COG1823	symporter activity
EFI48_RS03910	COG1924	4 iron, 4 sulfur cluster binding
EFI48_RS03915	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
EFI48_RS03920	COG0842	Transport permease protein
EFI48_RS03925	COG1131	(ABC) transporter
EFI48_RS03940	COG0163	prenyltransferase activity
EFI48_RS03945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EFI48_RS03950	COG0671	phosphoesterase, PA-phosphatase related
EFI48_RS03955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EFI48_RS03960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EFI48_RS03965	COG1151	hydroxylamine reductase activity
EFI48_RS03970	COG0783	Belongs to the Dps family
EFI48_RS03975	COG3023	N-Acetylmuramoyl-L-alanine amidase
EFI48_RS03980	COG4807	Protein conserved in bacteria
EFI48_RS03990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EFI48_RS03995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EFI48_RS04000	COG3956	TIGRFAM MazG family protein
EFI48_RS04005	COG0504	CTP synthase activity
EFI48_RS04010	COG0148	phosphopyruvate hydratase activity
EFI48_RS04055	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EFI48_RS04065	COG0488	(ABC) transporter
EFI48_RS04070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EFI48_RS04070	COG0617	tRNA 3'-terminal CCA addition
EFI48_RS04070	COG0517	IMP dehydrogenase activity
EFI48_RS04085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EFI48_RS04100	COG1794	racemase activity, acting on amino acids and derivatives
EFI48_RS04110	COG2731	YhcH YjgK YiaL family protein
EFI48_RS04120	COG0668	transmembrane transport
EFI48_RS04125	COG1376	ErfK ybiS ycfS ynhG family protein
EFI48_RS04135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EFI48_RS04140	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EFI48_RS04145	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EFI48_RS04155	COG0585	pseudouridine synthase activity
EFI48_RS04160	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EFI48_RS04165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EFI48_RS04170	COG1238	metal cluster binding
EFI48_RS04185	COG1902	pentaerythritol trinitrate reductase activity
EFI48_RS04195	COG2852	Protein conserved in bacteria
EFI48_RS04205	COG2957	Belongs to the agmatine deiminase family
EFI48_RS04210	COG0154	amidase activity
EFI48_RS04230	COG0513	Belongs to the DEAD box helicase family
EFI48_RS04235	COG2203	Gaf domain
EFI48_RS04235	COG2199	diguanylate cyclase activity
EFI48_RS04245	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
EFI48_RS04290	COG2816	NAD+ diphosphatase activity
EFI48_RS04325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EFI48_RS04340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EFI48_RS04345	COG4991	sh3 domain protein
EFI48_RS04355	COG2816	NAD+ diphosphatase activity
EFI48_RS04360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EFI48_RS04365	COG1940	carbohydrate kinase activity
EFI48_RS04370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EFI48_RS04375	COG0126	phosphoglycerate kinase activity
EFI48_RS04380	COG0191	fructose-bisphosphate aldolase activity
EFI48_RS04385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EFI48_RS04400	COG4232	protein-disulfide reductase activity
EFI48_RS04425	COG0354	folic acid binding
EFI48_RS04430	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EFI48_RS04440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EFI48_RS04445	COG1595	DNA-templated transcription, initiation
EFI48_RS04450	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
EFI48_RS04455	COG3026	antisigma factor binding
EFI48_RS04465	COG0481	GTPase activity
EFI48_RS04470	COG0681	Belongs to the peptidase S26 family
EFI48_RS04485	COG1381	Involved in DNA repair and RecF pathway recombination
EFI48_RS04490	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EFI48_RS04500	COG2350	Protein conserved in bacteria
EFI48_RS04505	COG2917	probably involved in intracellular septation
EFI48_RS04510	COG0076	glutamate decarboxylase activity
EFI48_RS04515	COG1272	protein, Hemolysin III
EFI48_RS04520	COG2985	domain, Protein
EFI48_RS04520	COG0569	domain protein
EFI48_RS04655	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
EFI48_RS04680	COG2313	pseudouridylate synthase activity
EFI48_RS04685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EFI48_RS04725	COG1765	OsmC-like protein
EFI48_RS04740	COG3954	Phosphoribulokinase
EFI48_RS04745	COG3089	Belongs to the UPF0270 family
EFI48_RS04750	COG5001	Diguanylate cyclase
EFI48_RS04750	COG4251	negative regulation of phosphorylation
EFI48_RS04750	COG3706	GGDEF domain
EFI48_RS04750	COG2203	Gaf domain
EFI48_RS04755	COG0429	hydrolase of the alpha beta-hydrolase fold
EFI48_RS04760	COG0784	Response regulator, receiver
EFI48_RS04760	COG0835	chemotaxis
EFI48_RS04770	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EFI48_RS04775	COG1047	Peptidyl-prolyl cis-trans
EFI48_RS04795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EFI48_RS04805	COG3340	Belongs to the peptidase S51 family
EFI48_RS04820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EFI48_RS04830	COG3721	Heme iron utilization protein
EFI48_RS04835	COG0748	coenzyme F420 binding
EFI48_RS04865	COG2814	Major facilitator Superfamily
EFI48_RS04875	COG3655	Transcriptional regulator
EFI48_RS04885	COG2205	protein histidine kinase activity
EFI48_RS04885	COG0784	Response regulator, receiver
EFI48_RS04885	COG5002	protein histidine kinase activity
EFI48_RS04895	COG3706	GGDEF domain
EFI48_RS04910	COG3397	chitin binding
EFI48_RS04955	COG0835	chemotaxis
EFI48_RS04955	COG0784	Response regulator, receiver
EFI48_RS04960	COG2755	lipolytic protein G-D-S-L family
EFI48_RS04965	COG4181	ATPase activity
EFI48_RS04970	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EFI48_RS04975	COG1090	epimerase
EFI48_RS04980	COG2200	EAL domain
EFI48_RS04985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EFI48_RS04990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EFI48_RS04995	COG3171	Protein conserved in bacteria
EFI48_RS05000	COG2066	Belongs to the glutaminase family
EFI48_RS05005	COG2897	thiosulfate sulfurtransferase activity
EFI48_RS05020	COG0521	Mo-molybdopterin cofactor biosynthetic process
EFI48_RS05030	COG2966	Psort location CytoplasmicMembrane, score
EFI48_RS05035	COG3610	response to peptide
EFI48_RS05050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EFI48_RS05055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EFI48_RS05065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EFI48_RS05080	COG0786	glutamate:sodium symporter activity
EFI48_RS05085	COG0252	asparaginase activity
EFI48_RS05090	COG3139	Protein of unknown function (DUF1315)
EFI48_RS05110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EFI48_RS05115	COG0321	lipoyl(octanoyl) transferase activity
EFI48_RS05120	COG2921	Belongs to the UPF0250 family
EFI48_RS05125	COG1686	Belongs to the peptidase S11 family
EFI48_RS05130	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EFI48_RS05135	COG2951	lytic endotransglycosylase activity
EFI48_RS05140	COG0772	Belongs to the SEDS family
EFI48_RS05145	COG0768	penicillin binding
EFI48_RS05150	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EFI48_RS05155	COG0799	negative regulation of ribosome biogenesis
EFI48_RS05160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EFI48_RS05175	COG0495	leucyl-tRNA aminoacylation
EFI48_RS05180	COG2888	peptidyl-tyrosine sulfation
EFI48_RS05185	COG0312	modulator of DNA gyrase
EFI48_RS05190	COG0312	modulator of DNA gyrase
EFI48_RS05195	COG0716	FMN binding
EFI48_RS05200	COG4974	Belongs to the 'phage' integrase family
EFI48_RS05210	COG1970	mechanosensitive ion channel activity
EFI48_RS05225	COG0789	Transcriptional regulator
EFI48_RS05230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EFI48_RS05235	COG4535	Mg2 and Co2 transporter CorC
EFI48_RS05240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EFI48_RS05245	COG1702	phosphate starvation-inducible protein PhoH
EFI48_RS05250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EFI48_RS05255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EFI48_RS05260	COG1335	isochorismatase
EFI48_RS05270	COG3706	GGDEF domain
EFI48_RS05275	COG0583	DNA-binding transcription factor activity
EFI48_RS05305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EFI48_RS05315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EFI48_RS05325	COG0516	GMP reductase activity
EFI48_RS05335	COG0642	Histidine kinase
EFI48_RS05350	COG4221	oxidoreductase activity
EFI48_RS05375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EFI48_RS05390	COG3214	Protein conserved in bacteria
EFI48_RS05400	COG2195	Cleaves the N-terminal amino acid of tripeptides
EFI48_RS05405	COG0700	Nucleoside recognition
EFI48_RS05410	COG3366	ferrous iron transmembrane transporter activity
EFI48_RS05415	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EFI48_RS05420	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EFI48_RS05425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EFI48_RS05430	COG1053	succinate dehydrogenase
EFI48_RS05440	COG0584	glycerophosphoryl diester phosphodiesterase
EFI48_RS05445	COG3264	Mechanosensitive ion channel
EFI48_RS05445	COG1511	domain protein
EFI48_RS05455	COG0739	heme binding
EFI48_RS05465	COG0583	DNA-binding transcription factor activity
EFI48_RS05485	COG0583	DNA-binding transcription factor activity
EFI48_RS05490	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EFI48_RS05520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EFI48_RS05525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EFI48_RS05535	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EFI48_RS05540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EFI48_RS05550	COG0180	Tryptophanyl-tRNA synthetase
EFI48_RS05560	COG0512	Glutamine amidotransferase of anthranilate synthase
EFI48_RS05565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EFI48_RS05575	COG1012	belongs to the aldehyde dehydrogenase family
EFI48_RS05590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EFI48_RS05600	COG1013	pyruvate-flavodoxin oxidoreductase activity
EFI48_RS05600	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EFI48_RS05600	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EFI48_RS05600	COG0674	pyruvate-flavodoxin oxidoreductase activity
EFI48_RS05605	COG0366	Alpha amylase catalytic
EFI48_RS05630	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EFI48_RS05640	COG0471	metal ion transport
EFI48_RS05640	COG0490	domain, Protein
EFI48_RS05715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EFI48_RS05720	COG1085	galactose-1-phosphate uridylyltransferase
EFI48_RS05725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EFI48_RS05730	COG1609	Transcriptional regulator
EFI48_RS05735	COG4580	involved in the transport of maltose and maltodextrins
EFI48_RS05760	COG2182	Extracellular solute-binding protein
EFI48_RS05765	COG1175	transmembrane transport
EFI48_RS05770	COG3833	ABC-type maltose transport systems, permease component
EFI48_RS05775	COG3867	Arabinogalactan endo-beta-1,4-galactanase
EFI48_RS05780	COG1874	Beta-galactosidase
EFI48_RS05785	COG1263	PTS System
EFI48_RS05785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EFI48_RS05795	COG0469	pyruvate kinase activity
EFI48_RS05810	COG2003	Belongs to the UPF0758 family
EFI48_RS05855	COG5377	YqaJ viral recombinase family
EFI48_RS05865	COG0012	GTP binding
EFI48_RS05870	COG0193	aminoacyl-tRNA hydrolase activity
EFI48_RS05875	COG0737	Belongs to the 5'-nucleotidase family
EFI48_RS05880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EFI48_RS05890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EFI48_RS05895	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EFI48_RS05900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EFI48_RS05905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EFI48_RS05910	COG2890	protein-(glutamine-N5) methyltransferase activity
EFI48_RS05920	COG2912	Transglutaminase-like superfamily
EFI48_RS05925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EFI48_RS05930	COG1301	dicarboxylic acid transport
EFI48_RS05945	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EFI48_RS05955	COG3408	Glycogen debranching enzyme
EFI48_RS05955	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
EFI48_RS05965	COG1881	PFAM PEBP family protein
EFI48_RS05970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EFI48_RS05985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EFI48_RS05995	COG0583	DNA-binding transcription factor activity
EFI48_RS06000	COG1028	Short-chain dehydrogenase reductase Sdr
EFI48_RS06005	COG0616	signal peptide processing
EFI48_RS06010	COG2211	Major facilitator Superfamily
EFI48_RS06015	COG3706	GGDEF domain
EFI48_RS06020	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EFI48_RS06030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EFI48_RS06035	COG0826	peptidase U32
EFI48_RS06040	COG2200	EAL domain
EFI48_RS06040	COG2203	Gaf domain
EFI48_RS06040	COG2199	diguanylate cyclase activity
EFI48_RS06060	COG2197	response regulator
EFI48_RS06090	COG3724	N-succinylarginine dihydrolase activity
EFI48_RS06105	COG0840	transmembrane signaling receptor activity
EFI48_RS06115	COG2971	BadF BadG BcrA BcrD
EFI48_RS06125	COG4608	Belongs to the ABC transporter superfamily
EFI48_RS06130	COG0444	Belongs to the ABC transporter superfamily
EFI48_RS06135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EFI48_RS06150	COG0784	Response regulator, receiver
EFI48_RS06150	COG2205	protein histidine kinase activity
EFI48_RS06180	COG3220	belongs to the UPF0276 family
EFI48_RS06210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EFI48_RS06215	COG1289	transmembrane transporter activity
EFI48_RS06220	COG0303	'Molybdopterin
EFI48_RS06225	COG0746	molybdenum cofactor guanylyltransferase activity
EFI48_RS06235	COG4662	Binding-protein-dependent transport system inner membrane component
EFI48_RS06250	COG3852	Histidine kinase
EFI48_RS06260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EFI48_RS06295	COG3383	formate dehydrogenase (NAD+) activity
EFI48_RS06295	COG3383	formate dehydrogenase (NAD+) activity
EFI48_RS06300	COG0437	4 iron, 4 sulfur cluster binding
EFI48_RS06320	COG0281	malic enzyme
EFI48_RS06340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFI48_RS06370	COG0837	glucose binding
EFI48_RS06375	COG1737	Transcriptional regulator
EFI48_RS06380	COG0469	pyruvate kinase activity
EFI48_RS06400	COG1677	Flagellar hook-basal body complex protein FliE
EFI48_RS06410	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EFI48_RS06460	COG1987	bacterial-type flagellum assembly
EFI48_RS06465	COG1684	flagellar biosynthetic protein fliR
EFI48_RS06475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EFI48_RS06500	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EFI48_RS06505	COG0643	Histidine kinase
EFI48_RS06505	COG0784	Response regulator, receiver
EFI48_RS06505	COG2198	Histidine kinase
EFI48_RS06510	COG2201	protein-glutamate methylesterase activity
EFI48_RS06515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EFI48_RS06520	COG1360	Flagellar Motor Protein
EFI48_RS06525	COG1192	Involved in chromosome partitioning
EFI48_RS06535	COG0835	chemotaxis
EFI48_RS06550	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EFI48_RS06555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EFI48_RS06560	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EFI48_RS06565	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EFI48_RS06570	COG1138	Cytochrome C-type biogenesis protein
EFI48_RS06575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EFI48_RS06580	COG4235	cytochrome complex assembly
EFI48_RS06580	COG3088	subunit of a heme lyase
EFI48_RS06590	COG2853	Lipoprotein
EFI48_RS06600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EFI48_RS06605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EFI48_RS06615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EFI48_RS06620	COG1882	Formate acetyltransferase
EFI48_RS06630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EFI48_RS06630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EFI48_RS06665	COG0259	pyridoxamine-phosphate oxidase activity
EFI48_RS06670	COG0625	glutathione transferase activity
EFI48_RS06690	COG2850	peptidyl-arginine hydroxylation
EFI48_RS06695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EFI48_RS06700	COG2915	High frequency lysogenization protein hflD homolog
EFI48_RS06705	COG0482	sulfurtransferase activity
EFI48_RS06715	COG1187	pseudouridine synthase activity
EFI48_RS06725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EFI48_RS06735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFI48_RS06735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EFI48_RS06735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EFI48_RS06755	COG5433	transposase activity
EFI48_RS06760	COG5433	transposase activity
EFI48_RS06770	COG1176	ABC-type spermidine putrescine transport system, permease component I
EFI48_RS06800	COG0583	DNA-binding transcription factor activity
EFI48_RS06805	COG1380	Effector of murein hydrolase LrgA
EFI48_RS06810	COG1346	cytolysis
EFI48_RS06840	COG0783	Belongs to the Dps family
EFI48_RS06860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EFI48_RS06870	COG1609	Transcriptional regulator
EFI48_RS06875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EFI48_RS06875	COG1263	PTS System
EFI48_RS06880	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EFI48_RS06885	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EFI48_RS06895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EFI48_RS06900	COG1960	acyl-CoA dehydrogenase activity
EFI48_RS06910	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EFI48_RS06970	COG2916	Histone family protein nucleoid-structuring protein H-NS
EFI48_RS06980	COG5642	Protein of unknown function (DUF2384)
EFI48_RS06985	COG2199	diguanylate cyclase activity
EFI48_RS06985	COG2203	Gaf domain
EFI48_RS06995	COG2199	diguanylate cyclase activity
EFI48_RS06995	COG2203	Gaf domain
EFI48_RS07005	COG3706	GGDEF domain
EFI48_RS07010	COG2197	response regulator
EFI48_RS07015	COG3604	Transcriptional regulator
EFI48_RS07020	COG1773	rubredoxin
EFI48_RS07020	COG0426	domain, Protein
EFI48_RS07025	COG0446	pyridine nucleotide-disulphide oxidoreductase
EFI48_RS07095	COG3383	formate dehydrogenase (NAD+) activity
EFI48_RS07105	COG2205	protein histidine kinase activity
EFI48_RS07105	COG0784	Response regulator, receiver
EFI48_RS07115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EFI48_RS07120	COG2867	negative regulation of translational initiation
EFI48_RS07125	COG2914	Belongs to the UPF0125 (RnfH) family
EFI48_RS07130	COG1473	amidohydrolase
EFI48_RS07135	COG1960	acyl-CoA dehydrogenase activity
EFI48_RS07140	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EFI48_RS07145	COG0121	glutamine amidotransferase
EFI48_RS07175	COG2197	response regulator
EFI48_RS07180	COG3850	Histidine kinase
EFI48_RS07185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EFI48_RS07190	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EFI48_RS07200	COG0243	molybdopterin cofactor binding
EFI48_RS07205	COG0437	4 iron, 4 sulfur cluster binding
EFI48_RS07210	COG0348	domain, Protein
EFI48_RS07220	COG3005	denitrification pathway
EFI48_RS07225	COG0521	Mo-molybdopterin cofactor biosynthetic process
EFI48_RS07230	COG0315	cyclic pyranopterin monophosphate synthase activity
EFI48_RS07235	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EFI48_RS07240	COG0314	molybdopterin synthase activity
EFI48_RS07255	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EFI48_RS07260	COG2267	carboxylic ester hydrolase activity
EFI48_RS07265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EFI48_RS07275	COG0302	gtp cyclohydrolase
EFI48_RS07280	COG0840	transmembrane signaling receptor activity
EFI48_RS07285	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EFI48_RS07295	COG0583	DNA-binding transcription factor activity
EFI48_RS07300	COG2353	YceI-like domain
EFI48_RS07310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EFI48_RS07325	COG2195	Cleaves the N-terminal amino acid of tripeptides
EFI48_RS07335	COG1166	arginine decarboxylase activity
EFI48_RS07345	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EFI48_RS07365	COG0814	amino acid
EFI48_RS07375	COG3681	Belongs to the UPF0597 family
EFI48_RS07380	COG2964	Protein conserved in bacteria
EFI48_RS07395	COG2932	Transcriptional regulator
EFI48_RS07510	COG0640	Transcriptional regulator
EFI48_RS07520	COG4373	Mu-like prophage FluMu protein gp28
EFI48_RS07525	COG4383	Mu-like prophage protein gp29
EFI48_RS07560	COG4388	Caudovirus prohead serine protease
EFI48_RS07565	COG4397	Mu-like prophage major head subunit gpT
EFI48_RS07645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EFI48_RS07650	COG1288	antiporter activity
EFI48_RS07655	COG0436	Aminotransferase
EFI48_RS07665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EFI48_RS07670	COG1196	nuclear chromosome segregation
EFI48_RS07670	COG0739	heme binding
EFI48_RS07670	COG0741	lytic transglycosylase activity
EFI48_RS07685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EFI48_RS07695	COG0788	formyltetrahydrofolate deformylase activity
EFI48_RS07700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EFI48_RS07710	COG3118	belongs to the thioredoxin family
EFI48_RS07720	COG0791	NLP P60 protein
EFI48_RS07725	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EFI48_RS07735	COG0471	metal ion transport
EFI48_RS07745	COG1388	LysM domain
EFI48_RS07745	COG1376	ErfK ybiS ycfS ynhG family protein
EFI48_RS07760	COG1447	Phosphotransferase system cellobiose-specific component IIA
EFI48_RS07765	COG2723	6-phospho-beta-galactosidase activity
EFI48_RS07775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EFI48_RS07780	COG5297	Belongs to the glycosyl hydrolase family 6
EFI48_RS07780	COG2273	Hydrolase Family 16
EFI48_RS07785	COG1472	Belongs to the glycosyl hydrolase 3 family
EFI48_RS07795	COG2182	Extracellular solute-binding protein
EFI48_RS07800	COG1609	Transcriptional regulator
EFI48_RS07820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EFI48_RS07825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EFI48_RS07830	COG0745	RESPONSE REGULATOR receiver
EFI48_RS07835	COG5002	protein histidine kinase activity
EFI48_RS07835	COG5000	phosphorelay sensor kinase activity
EFI48_RS07860	COG1388	LysM domain
EFI48_RS07860	COG0741	lytic transglycosylase activity
EFI48_RS07865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EFI48_RS07870	COG2226	methyltransferase
EFI48_RS07875	COG0328	RNA-DNA hybrid ribonuclease activity
EFI48_RS07880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EFI48_RS07890	COG3437	response regulator, receiver
EFI48_RS07890	COG0784	Response regulator, receiver
EFI48_RS07895	COG2375	cellular response to nickel ion
EFI48_RS07900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EFI48_RS07905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EFI48_RS07910	COG1120	ATPase activity
EFI48_RS07915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EFI48_RS07925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EFI48_RS07930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EFI48_RS07965	COG0708	Exodeoxyribonuclease III
EFI48_RS07995	COG3132	Protein of unknown function, DUF480
EFI48_RS08000	COG3300	MHYT domain
EFI48_RS08000	COG5001	Diguanylate cyclase
EFI48_RS08010	COG2841	Protein conserved in bacteria
EFI48_RS08020	COG0534	Mate efflux family protein
EFI48_RS08055	COG1309	transcriptional regulator
EFI48_RS08090	COG3152	Membrane
EFI48_RS08105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EFI48_RS08115	COG1482	cell wall glycoprotein biosynthetic process
EFI48_RS08120	COG2207	Transcriptional regulator
EFI48_RS08125	COG0538	isocitrate dehydrogenase activity
EFI48_RS08135	COG3048	D-serine ammonia-lyase activity
EFI48_RS08140	COG2610	gluconate transmembrane transporter activity
EFI48_RS08145	COG0583	DNA-binding transcription factor activity
EFI48_RS08155	COG0791	NLP P60 protein
EFI48_RS08160	COG0583	DNA-binding transcription factor activity
EFI48_RS08165	COG0450	alkyl hydroperoxide reductase
EFI48_RS08185	COG0500	methyltransferase
EFI48_RS08190	COG4106	trans-aconitate 2-methyltransferase activity
EFI48_RS08195	COG1801	Protein of unknown function DUF72
EFI48_RS08205	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EFI48_RS08210	COG0217	transcriptional regulatory protein
EFI48_RS08220	COG1454	alcohol dehydrogenase
EFI48_RS08220	COG1012	belongs to the aldehyde dehydrogenase family
EFI48_RS08225	COG2095	MarC family integral membrane protein
EFI48_RS08235	COG0601	transmembrane transport
EFI48_RS08240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EFI48_RS08255	COG0861	Integral membrane protein TerC family
EFI48_RS08260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EFI48_RS08290	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EFI48_RS08295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EFI48_RS08300	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EFI48_RS08305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EFI48_RS08310	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EFI48_RS08315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EFI48_RS08330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EFI48_RS08335	COG0505	Belongs to the CarA family
EFI48_RS08340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EFI48_RS08350	COG0287	Prephenate dehydrogenase
EFI48_RS08350	COG1605	Chorismate mutase
EFI48_RS08355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EFI48_RS08365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EFI48_RS08370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EFI48_RS08405	COG0537	adenosine 5'-monophosphoramidase activity
EFI48_RS08420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EFI48_RS08435	COG1301	dicarboxylic acid transport
EFI48_RS08440	COG0840	transmembrane signaling receptor activity
EFI48_RS08450	COG2354	Protein conserved in bacteria
EFI48_RS08460	COG2233	PERMEase
EFI48_RS08465	COG3150	esterase
EFI48_RS08470	COG1252	NADH dehydrogenase
EFI48_RS08480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EFI48_RS08485	COG3300	MHYT domain
EFI48_RS08485	COG5001	Diguanylate cyclase
EFI48_RS08490	COG0446	pyridine nucleotide-disulphide oxidoreductase
EFI48_RS08500	COG2373	Large extracellular alpha-helical protein
EFI48_RS08505	COG4953	penicillin-binding protein 1C
EFI48_RS08520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EFI48_RS08520	COG0301	tRNA thio-modification
EFI48_RS08580	COG2089	acid synthase
EFI48_RS08590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EFI48_RS08595	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EFI48_RS08605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EFI48_RS08610	COG1086	Polysaccharide biosynthesis protein
EFI48_RS08625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EFI48_RS08635	COG0483	inositol monophosphate 1-phosphatase activity
EFI48_RS08645	COG0625	glutathione transferase activity
EFI48_RS08650	COG2814	Major facilitator Superfamily
EFI48_RS08655	COG0583	DNA-binding transcription factor activity
EFI48_RS08660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EFI48_RS08665	COG0243	molybdopterin cofactor binding
EFI48_RS08685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EFI48_RS08690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EFI48_RS08700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EFI48_RS08705	COG0509	glycine decarboxylation via glycine cleavage system
EFI48_RS08710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EFI48_RS08710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EFI48_RS08795	COG0840	transmembrane signaling receptor activity
EFI48_RS08825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EFI48_RS08830	COG0574	Belongs to the PEP-utilizing enzyme family
EFI48_RS08830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EFI48_RS08845	COG1464	Belongs to the NlpA lipoprotein family
EFI48_RS08850	COG3083	sulfuric ester hydrolase activity
EFI48_RS08855	COG3082	Protein of unknown function (DUF1414)
EFI48_RS08860	COG3081	Nucleoid-associated protein
EFI48_RS08870	COG1175	transmembrane transport
EFI48_RS08875	COG3833	ABC-type maltose transport systems, permease component
EFI48_RS08880	COG3842	ATPase activity
EFI48_RS08910	COG4783	chaperone-mediated protein folding
EFI48_RS08920	COG1393	Belongs to the ArsC family
EFI48_RS08930	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EFI48_RS08935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFI48_RS08940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EFI48_RS08945	COG2431	L-lysine efflux transmembrane transporter activity
EFI48_RS08955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFI48_RS08965	COG4160	amino acid transport
EFI48_RS08970	COG0564	pseudouridine synthase activity
EFI48_RS08985	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EFI48_RS08995	COG0625	glutathione transferase activity
EFI48_RS09020	COG0642	Histidine kinase
EFI48_RS09025	COG2261	transglycosylase associated protein
EFI48_RS09040	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EFI48_RS09050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EFI48_RS09055	COG0215	cysteine-tRNA ligase activity
EFI48_RS09060	COG0210	DNA helicase
EFI48_RS09100	COG2119	membrane
EFI48_RS09105	COG0023	Translation Initiation Factor
EFI48_RS09130	COG0513	Belongs to the DEAD box helicase family
EFI48_RS09140	COG0493	'glutamate synthase
EFI48_RS09145	COG0070	glutamate synthase
EFI48_RS09145	COG0069	glutamate synthase activity
EFI48_RS09145	COG0067	glutamate synthase
EFI48_RS09150	COG1242	4 iron, 4 sulfur cluster binding
EFI48_RS09205	COG3634	alkyl hydroperoxide reductase activity
EFI48_RS09215	COG0517	IMP dehydrogenase activity
EFI48_RS09220	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EFI48_RS09225	COG0343	queuine tRNA-ribosyltransferase activity
EFI48_RS09230	COG1862	Preprotein translocase
EFI48_RS09235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EFI48_RS09240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EFI48_RS09255	COG0826	peptidase U32
EFI48_RS09260	COG0826	peptidase U32
EFI48_RS09265	COG3154	lipid carrier protein
EFI48_RS09285	COG1104	cysteine desulfurase activity
EFI48_RS09290	COG0822	iron-sulfur transferase activity
EFI48_RS09300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EFI48_RS09305	COG0443	Heat shock 70 kDa protein
EFI48_RS09310	COG0633	Ferredoxin
EFI48_RS09325	COG0105	UTP biosynthetic process
EFI48_RS09330	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EFI48_RS09345	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EFI48_RS09350	COG0124	histidyl-tRNA synthetase
EFI48_RS09355	COG2976	Protein conserved in bacteria
EFI48_RS09360	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EFI48_RS09365	COG1160	GTP binding
EFI48_RS09370	COG1645	bacterial-type flagellum-dependent swarming motility
EFI48_RS09380	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EFI48_RS09385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EFI48_RS09385	COG0047	phosphoribosylformylglycinamidine synthase activity
EFI48_RS09390	COG2199	diguanylate cyclase activity
EFI48_RS09390	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EFI48_RS09405	COG1007	ATP synthesis coupled electron transport
EFI48_RS09410	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EFI48_RS09420	COG0713	ATP synthesis coupled electron transport
EFI48_RS09425	COG0839	Belongs to the complex I subunit 6 family
EFI48_RS09430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EFI48_RS09435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EFI48_RS09440	COG1034	ATP synthesis coupled electron transport
EFI48_RS09455	COG0649	NAD binding
EFI48_RS09455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EFI48_RS09460	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EFI48_RS09465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EFI48_RS09485	COG1770	oligopeptidase
EFI48_RS09490	COG4771	TonB-dependent receptor
EFI48_RS09495	COG1360	Flagellar Motor Protein
EFI48_RS09500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EFI48_RS09515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EFI48_RS09525	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
EFI48_RS09530	COG4597	amino acid ABC transporter
EFI48_RS09535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFI48_RS09540	COG0765	amino acid transport
EFI48_RS09545	COG1126	abc transporter atp-binding protein
EFI48_RS09555	COG0724	RNA recognition motif
EFI48_RS09560	COG4989	oxidoreductase activity
EFI48_RS09585	COG3437	response regulator, receiver
EFI48_RS09590	COG0583	DNA-binding transcription factor activity
EFI48_RS09595	COG3300	MHYT domain
EFI48_RS09595	COG5001	Diguanylate cyclase
EFI48_RS09600	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EFI48_RS09620	COG2814	Major facilitator Superfamily
EFI48_RS09635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EFI48_RS09640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EFI48_RS09645	COG0539	negative regulation of cytoplasmic translation
EFI48_RS09650	COG0776	regulation of translation
EFI48_RS09660	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EFI48_RS09680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EFI48_RS09685	COG0602	queuosine metabolic process
EFI48_RS09690	COG3530	Putative quorum-sensing-regulated virulence factor
EFI48_RS09695	COG2096	Adenosyltransferase
EFI48_RS09700	COG2916	Histone family protein nucleoid-structuring protein H-NS
EFI48_RS09705	COG1757	Na H antiporter
EFI48_RS09710	COG1435	thymidine kinase activity
EFI48_RS09730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EFI48_RS09735	COG0326	Molecular chaperone. Has ATPase activity
EFI48_RS09740	COG4172	Belongs to the ABC transporter superfamily
EFI48_RS09745	COG4172	Belongs to the ABC transporter superfamily
EFI48_RS09755	COG4168	peptide transport system, permease
EFI48_RS09765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EFI48_RS09770	COG1842	Phage shock protein A
EFI48_RS09785	COG3106	COG3106 Predicted ATPase
EFI48_RS09790	COG3768	UPF0283 membrane protein
EFI48_RS09795	COG0583	DNA-binding transcription factor activity
EFI48_RS09800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EFI48_RS09805	COG3842	ATPase activity
EFI48_RS09810	COG1176	ABC-type spermidine putrescine transport system, permease component I
EFI48_RS09815	COG1177	transmembrane transport
EFI48_RS09820	COG1012	belongs to the aldehyde dehydrogenase family
EFI48_RS09830	COG2154	pterin-4-alpha-carbinolamine dehydratase
EFI48_RS09850	COG2199	diguanylate cyclase activity
EFI48_RS09855	COG2885	chlorophyll binding
EFI48_RS09860	COG0861	Integral membrane protein TerC family
EFI48_RS09890	COG2910	NAD(P)H-binding
EFI48_RS09895	COG0583	DNA-binding transcription factor activity
EFI48_RS09900	COG0583	DNA-binding transcription factor activity
EFI48_RS09905	COG2271	Major facilitator Superfamily
EFI48_RS09915	COG1335	isochorismatase
EFI48_RS09930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EFI48_RS09940	COG0583	DNA-binding transcription factor activity
EFI48_RS09945	COG2723	6-phospho-beta-galactosidase activity
EFI48_RS09950	COG1944	ATP diphosphatase activity
EFI48_RS09955	COG2116	formate transmembrane transporter activity
EFI48_RS09960	COG1882	Formate acetyltransferase
EFI48_RS09965	COG2983	Belongs to the UPF0260 family
EFI48_RS09980	COG0058	SHG alpha-glucan phosphorylase activity
EFI48_RS09985	COG0471	metal ion transport
EFI48_RS09990	COG3118	belongs to the thioredoxin family
EFI48_RS10000	COG1132	(ABC) transporter
EFI48_RS10005	COG1132	(ABC) transporter
EFI48_RS10015	COG2501	S4 domain
EFI48_RS10030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EFI48_RS10075	COG2009	succinate dehydrogenase
EFI48_RS10080	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EFI48_RS10085	COG1053	succinate dehydrogenase
EFI48_RS10095	COG0567	Dehydrogenase, E1 component
EFI48_RS10100	COG0508	dehydrogenase complex catalyzes the overall conversion of
EFI48_RS10105	COG0045	succinate-CoA ligase (ADP-forming) activity
EFI48_RS10125	COG1584	GPR1 FUN34 yaaH family protein
EFI48_RS10155	COG1024	Enoyl-CoA hydratase
EFI48_RS10160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EFI48_RS10165	COG1960	acyl-CoA dehydrogenase activity
EFI48_RS10170	COG1960	acyl-CoA dehydrogenase activity
EFI48_RS10175	COG1024	Enoyl-CoA hydratase
EFI48_RS10180	COG1024	Enoyl-CoA hydratase
EFI48_RS10190	COG1028	Short-chain dehydrogenase reductase Sdr
EFI48_RS10200	COG0730	response to heat
EFI48_RS10240	COG0784	Response regulator, receiver
EFI48_RS10240	COG2205	protein histidine kinase activity
EFI48_RS10280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EFI48_RS10285	COG1215	transferase activity, transferring glycosyl groups
EFI48_RS10290	COG0438	transferase activity, transferring glycosyl groups
EFI48_RS10335	COG0438	transferase activity, transferring glycosyl groups
EFI48_RS10355	COG0438	transferase activity, transferring glycosyl groups
EFI48_RS10360	COG0438	transferase activity, transferring glycosyl groups
EFI48_RS10365	COG5001	Diguanylate cyclase
EFI48_RS10365	COG2203	Gaf domain
EFI48_RS10365	COG4251	negative regulation of phosphorylation
EFI48_RS10365	COG3706	GGDEF domain
EFI48_RS10370	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EFI48_RS10375	COG0437	4 iron, 4 sulfur cluster binding
EFI48_RS10380	COG5557	Pfam Polysulphide reductase, NrfD
EFI48_RS10385	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EFI48_RS10390	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EFI48_RS10395	COG1773	rubredoxin
EFI48_RS10410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EFI48_RS10420	COG1124	(ABC) transporter
EFI48_RS10425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EFI48_RS10430	COG0375	protein maturation
EFI48_RS10435	COG0309	Hydrogenase expression formation protein (HypE)
EFI48_RS10445	COG0298	carbon dioxide binding
EFI48_RS10450	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EFI48_RS10460	COG1921	L-seryl-tRNASec selenium transferase activity
EFI48_RS10465	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EFI48_RS10475	COG3260	NADH ubiquinone oxidoreductase 20
EFI48_RS10480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EFI48_RS10485	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
EFI48_RS10485	COG3261	NADH dehydrogenase
EFI48_RS10490	COG0650	Formate hydrogenlyase subunit 4
EFI48_RS10495	COG0651	ATP synthesis coupled electron transport
EFI48_RS10500	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EFI48_RS10505	COG3158	transport of potassium into the cell
EFI48_RS10510	COG1196	nuclear chromosome segregation
EFI48_RS10520	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EFI48_RS10545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EFI48_RS10550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EFI48_RS10555	COG3046	protein related to deoxyribodipyrimidine photolyase
EFI48_RS10565	COG3033	Beta-eliminating lyase
EFI48_RS10570	COG0295	cytidine deaminase activity
EFI48_RS10575	COG1346	cytolysis
EFI48_RS10580	COG1380	Effector of murein hydrolase LrgA
EFI48_RS10585	COG3345	alpha-galactosidase
EFI48_RS10595	COG2925	Exonuclease
EFI48_RS10600	COG0641	radical SAM
EFI48_RS10625	COG2304	oxidoreductase activity
EFI48_RS10630	COG2304	oxidoreductase activity
EFI48_RS10645	COG0714	Associated with various cellular activities
EFI48_RS10650	COG3119	arylsulfatase activity
EFI48_RS10655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EFI48_RS10660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EFI48_RS10660	COG0517	IMP dehydrogenase activity
EFI48_RS10660	COG0617	tRNA 3'-terminal CCA addition
EFI48_RS10665	COG1643	Atp-dependent helicase
EFI48_RS10675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EFI48_RS10690	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EFI48_RS10695	COG2067	long-chain fatty acid transport protein
EFI48_RS10700	COG2067	long-chain fatty acid transport protein
EFI48_RS10710	COG1595	DNA-templated transcription, initiation
EFI48_RS10720	COG2304	oxidoreductase activity
EFI48_RS10740	COG0714	Associated with various cellular activities
EFI48_RS10745	COG0183	Belongs to the thiolase family
EFI48_RS10750	COG1024	Enoyl-CoA hydratase
EFI48_RS10750	COG1250	3-hydroxyacyl-CoA dehydrogenase
EFI48_RS10755	COG2719	SpoVR family
EFI48_RS10760	COG2718	Belongs to the UPF0229 family
EFI48_RS10765	COG2766	serine protein kinase
EFI48_RS10770	COG0514	ATP-dependent DNA helicase (RecQ)
EFI48_RS10775	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EFI48_RS10785	COG0814	amino acid
EFI48_RS10790	COG0494	nUDIX hydrolase
EFI48_RS10805	COG2824	Alkylphosphonate utilization operon protein PhnA
EFI48_RS10825	COG0406	alpha-ribazole phosphatase activity
EFI48_RS10830	COG3706	GGDEF domain
EFI48_RS10835	COG2840	Smr protein MutS2
EFI48_RS10840	COG2890	protein-(glutamine-N5) methyltransferase activity
EFI48_RS10845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EFI48_RS10855	COG0513	Belongs to the DEAD box helicase family
EFI48_RS10865	COG3788	relative of glutathione S-transferase, MAPEG superfamily
EFI48_RS10875	COG0814	amino acid
EFI48_RS10880	COG1609	Transcriptional regulator
EFI48_RS10885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFI48_RS10885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFI48_RS10890	COG1105	Belongs to the carbohydrate kinase PfkB family
EFI48_RS10895	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EFI48_RS10895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EFI48_RS10895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EFI48_RS10900	COG1530	ribonuclease E activity
EFI48_RS10915	COG0424	maF-like protein
EFI48_RS10920	COG1399	metal-binding, possibly nucleic acid-binding protein
EFI48_RS10925	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EFI48_RS10930	COG0416	fatty acid biosynthetic process
EFI48_RS10935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EFI48_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
EFI48_RS10950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EFI48_RS10955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EFI48_RS10960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EFI48_RS10965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EFI48_RS10970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EFI48_RS10975	COG0470	DNA polymerase III
EFI48_RS10980	COG0084	hydrolase, TatD family'
EFI48_RS10995	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EFI48_RS10995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EFI48_RS11000	COG3008	intermembrane lipid transfer
EFI48_RS11005	COG2995	paraquat-inducible protein a
EFI48_RS11015	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EFI48_RS11020	COG0372	Belongs to the citrate synthase family
EFI48_RS11065	COG4221	oxidoreductase activity
EFI48_RS11070	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EFI48_RS11075	COG3141	response to X-ray
EFI48_RS11110	COG1067	ATP-dependent peptidase activity
EFI48_RS11115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EFI48_RS11125	COG0488	(ABC) transporter
EFI48_RS11135	COG0116	Belongs to the methyltransferase superfamily
EFI48_RS11135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EFI48_RS11140	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EFI48_RS11145	COG0254	rRNA binding
EFI48_RS11160	COG0167	dihydroorotate dehydrogenase activity
EFI48_RS11165	COG2902	Dehydrogenase
EFI48_RS11175	COG0308	aminopeptidase N
EFI48_RS11185	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EFI48_RS11190	COG1956	GAF domain-containing protein
EFI48_RS11200	COG3278	Belongs to the heme-copper respiratory oxidase family
EFI48_RS11215	COG2010	Cytochrome c
EFI48_RS11225	COG2217	Heavy metal translocating P-type atpase
EFI48_RS11240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EFI48_RS11245	COG0589	response to stress
EFI48_RS11250	COG0037	tRNA processing
EFI48_RS11275	COG1177	transmembrane transport
EFI48_RS11295	COG0625	glutathione transferase activity
EFI48_RS11300	COG1869	D-ribose catabolic process
EFI48_RS11305	COG1129	ABC transporter
EFI48_RS11310	COG1172	Belongs to the binding-protein-dependent transport system permease family
EFI48_RS11315	COG1879	ABC-type sugar transport system periplasmic component
EFI48_RS11320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EFI48_RS11325	COG1609	Transcriptional regulator
EFI48_RS11330	COG5001	Diguanylate cyclase
EFI48_RS11330	COG3300	MHYT domain
EFI48_RS11355	COG0784	Response regulator, receiver
EFI48_RS11355	COG2205	protein histidine kinase activity
EFI48_RS11360	COG0776	regulation of translation
EFI48_RS11365	COG0072	phenylalanine-tRNA ligase activity
EFI48_RS11365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EFI48_RS11370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EFI48_RS11375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EFI48_RS11380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EFI48_RS11385	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EFI48_RS11390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EFI48_RS11405	COG0366	Alpha amylase catalytic
EFI48_RS11415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EFI48_RS11425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EFI48_RS11430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EFI48_RS11435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EFI48_RS11440	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EFI48_RS11445	COG3313	Fe-S protein
EFI48_RS11450	COG0306	phosphate transporter
EFI48_RS11455	COG0717	Belongs to the dCTP deaminase family
EFI48_RS11460	COG0572	uridine kinase
EFI48_RS11465	COG0489	protein tyrosine kinase activity
EFI48_RS11470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EFI48_RS11470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EFI48_RS11480	COG1254	Belongs to the acylphosphatase family
EFI48_RS11485	COG0840	transmembrane signaling receptor activity
EFI48_RS11490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EFI48_RS11495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EFI48_RS11510	COG0709	Synthesizes selenophosphate from selenide and ATP
EFI48_RS11515	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EFI48_RS11520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EFI48_RS11535	COG0318	PFAM AMP-dependent synthetase and ligase
EFI48_RS11540	COG2267	carboxylic ester hydrolase activity
EFI48_RS11550	COG1214	PFAM Peptidase M22, glycoprotease
EFI48_RS11555	COG1199	ATP-dependent helicase activity
EFI48_RS11565	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EFI48_RS11570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EFI48_RS11575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EFI48_RS11580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EFI48_RS11580	COG0131	Imidazoleglycerol-phosphate dehydratase
EFI48_RS11585	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EFI48_RS11590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EFI48_RS11595	COG0107	imidazoleglycerol-phosphate synthase activity
EFI48_RS11610	COG2199	diguanylate cyclase activity
EFI48_RS11615	COG0318	PFAM AMP-dependent synthetase and ligase
EFI48_RS11625	COG3134	Outer membrane lipoprotein
EFI48_RS11630	COG2080	2 iron, 2 sulfur cluster binding
EFI48_RS11635	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EFI48_RS11640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EFI48_RS11645	COG2252	PERMEase
EFI48_RS11650	COG0402	S-adenosylhomocysteine deaminase activity
EFI48_RS11655	COG2233	PERMEase
EFI48_RS11660	COG2080	2 iron, 2 sulfur cluster binding
EFI48_RS11660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EFI48_RS11665	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EFI48_RS11670	COG0402	S-adenosylhomocysteine deaminase activity
EFI48_RS11675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EFI48_RS11675	COG0493	'glutamate synthase
EFI48_RS11680	COG2068	MobA-Related Protein
EFI48_RS11685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EFI48_RS11690	COG3608	succinylglutamate desuccinylase aspartoacylase
EFI48_RS11690	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EFI48_RS11700	COG0697	spore germination
EFI48_RS11705	COG0549	Belongs to the carbamate kinase family
EFI48_RS11715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EFI48_RS11720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EFI48_RS11725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EFI48_RS11760	COG0242	peptide deformylase activity
EFI48_RS11775	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EFI48_RS11780	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EFI48_RS11790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EFI48_RS11795	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EFI48_RS11805	COG0205	6-phosphofructokinase activity
EFI48_RS11815	COG3123	guanosine phosphorylase activity
EFI48_RS11820	COG1760	l-serine dehydratase
EFI48_RS11830	COG1760	l-serine dehydratase
EFI48_RS11835	COG3100	YcgL domain-containing protein
EFI48_RS11840	COG0850	regulation of cytokinetic process
EFI48_RS11845	COG2894	cell division
EFI48_RS11850	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EFI48_RS11855	COG3099	Belongs to the UPF0263 family
EFI48_RS11860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EFI48_RS11905	COG0697	spore germination
EFI48_RS11910	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EFI48_RS11915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EFI48_RS11925	COG0307	riboflavin synthase, alpha
EFI48_RS11970	COG3829	transcription factor binding
EFI48_RS11985	COG4681	YaeQ
EFI48_RS12000	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EFI48_RS12005	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EFI48_RS12010	COG0586	Pfam SNARE associated Golgi protein
EFI48_RS12020	COG0556	nucleotide-excision repair
EFI48_RS12035	COG2985	domain, Protein
EFI48_RS12035	COG0569	domain protein
EFI48_RS12040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EFI48_RS12045	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EFI48_RS12045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EFI48_RS12060	COG3069	C4-dicarboxylate transmembrane transporter activity
EFI48_RS12075	COG1451	nucleotide metabolic process
EFI48_RS12090	COG0417	DNA replication proofreading
EFI48_RS12115	COG1560	Kdo2-lipid A biosynthetic process
EFI48_RS12120	COG1560	Kdo2-lipid A biosynthetic process
EFI48_RS12135	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EFI48_RS12140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EFI48_RS12145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EFI48_RS12150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EFI48_RS12155	COG2832	Protein of unknown function (DUF454)
EFI48_RS12160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EFI48_RS12175	COG1011	Hydrolase
EFI48_RS12180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EFI48_RS12230	COG3593	DNA synthesis involved in DNA repair
EFI48_RS12245	COG0583	DNA-binding transcription factor activity
EFI48_RS12250	COG0730	response to heat
EFI48_RS12255	COG3148	PFAM DTW domain containing protein
EFI48_RS12260	COG1940	carbohydrate kinase activity
EFI48_RS12260	COG1846	Transcriptional regulator
EFI48_RS12265	COG0840	transmembrane signaling receptor activity
EFI48_RS12270	COG3012	SEC-C Motif Domain Protein
EFI48_RS12275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EFI48_RS12280	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EFI48_RS12285	COG0247	lactate metabolic process
EFI48_RS12300	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EFI48_RS12305	COG0437	4 iron, 4 sulfur cluster binding
EFI48_RS12310	COG3301	Polysulphide reductase, NrfD
EFI48_RS12315	COG1138	Cytochrome C-type biogenesis protein
EFI48_RS12325	COG4235	cytochrome complex assembly
EFI48_RS12325	COG3088	subunit of a heme lyase
EFI48_RS12330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EFI48_RS12335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EFI48_RS12340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EFI48_RS12350	COG1840	ABC-type Fe3 transport system, periplasmic component
EFI48_RS12355	COG3842	ATPase activity
EFI48_RS12365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EFI48_RS12370	COG2801	Transposase and inactivated derivatives
EFI48_RS12385	COG1115	amino acid carrier protein
EFI48_RS12415	COG4695	Portal protein
EFI48_RS12420	COG1024	Enoyl-CoA hydratase
EFI48_RS12435	COG3162	membrane
EFI48_RS12440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EFI48_RS12445	COG0488	(ABC) transporter
EFI48_RS12450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EFI48_RS12455	COG0776	regulation of translation
EFI48_RS12460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EFI48_RS12465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EFI48_RS12470	COG0740	serine-type endopeptidase activity
EFI48_RS12475	COG0544	peptidyl-prolyl cis-trans isomerase activity
EFI48_RS12490	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EFI48_RS12495	COG4591	ABC-type transport system involved in lipoprotein release permease component
EFI48_RS12500	COG1136	(ABC) transporter
EFI48_RS12505	COG4591	ABC-type transport system involved in lipoprotein release permease component
EFI48_RS12515	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EFI48_RS12520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EFI48_RS12525	COG4166	transmembrane transport
EFI48_RS12530	COG0697	spore germination
EFI48_RS12540	COG2062	phosphohistidine phosphatase, SixA
EFI48_RS12545	COG1025	Belongs to the peptidase M16 family
EFI48_RS12585	COG0519	Catalyzes the synthesis of GMP from XMP
EFI48_RS12585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EFI48_RS12590	COG0517	IMP dehydrogenase activity
EFI48_RS12590	COG0516	GMP reductase activity
EFI48_RS12595	COG1278	Cold shock
EFI48_RS12600	COG1570	exodeoxyribonuclease VII activity
EFI48_RS12605	COG2188	Transcriptional regulator
EFI48_RS12610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EFI48_RS12610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFI48_RS12610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EFI48_RS12615	COG0383	alpha-mannosidase activity
EFI48_RS12620	COG1181	Belongs to the D-alanine--D-alanine ligase family
EFI48_RS12630	COG0386	Belongs to the glutathione peroxidase family
EFI48_RS12635	COG0513	Belongs to the DEAD box helicase family
EFI48_RS12650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EFI48_RS12655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EFI48_RS12660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EFI48_RS12680	COG0644	oxidoreductase
EFI48_RS12680	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EFI48_RS12685	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EFI48_RS12685	COG0644	oxidoreductase
EFI48_RS12720	COG3300	MHYT domain
EFI48_RS12720	COG5001	Diguanylate cyclase
EFI48_RS12735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EFI48_RS12745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EFI48_RS12750	COG0563	adenylate kinase activity
EFI48_RS12760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EFI48_RS12765	COG1286	toxin biosynthetic process
EFI48_RS12770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EFI48_RS12775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EFI48_RS12780	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EFI48_RS12785	COG1674	ftsk spoiiie
EFI48_RS12785	COG0531	amino acid
EFI48_RS12795	COG0686	Belongs to the AlaDH PNT family
EFI48_RS12800	COG0492	ferredoxin-NADP+ reductase activity
EFI48_RS12805	COG3706	GGDEF domain
EFI48_RS12810	COG3134	Outer membrane lipoprotein
EFI48_RS12815	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EFI48_RS12820	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EFI48_RS12825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EFI48_RS12830	COG0542	response to heat
EFI48_RS12835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EFI48_RS12840	COG1278	Cold shock
EFI48_RS12845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EFI48_RS12865	COG0745	RESPONSE REGULATOR receiver
EFI48_RS12870	COG2205	protein histidine kinase activity
EFI48_RS12880	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EFI48_RS12880	COG0392	lysyltransferase activity
EFI48_RS12900	COG5642	Protein of unknown function (DUF2384)
EFI48_RS12905	COG2801	Transposase and inactivated derivatives
EFI48_RS12965	COG4974	Belongs to the 'phage' integrase family
EFI48_RS12980	COG0659	secondary active sulfate transmembrane transporter activity
EFI48_RS13005	COG0514	ATP-dependent DNA helicase (RecQ)
EFI48_RS13025	COG0672	)-iron permease
EFI48_RS13045	COG2814	Major facilitator Superfamily
EFI48_RS13060	COG1136	(ABC) transporter
EFI48_RS13065	COG0577	efflux transmembrane transporter activity
EFI48_RS13080	COG0596	Alpha beta hydrolase
EFI48_RS13100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EFI48_RS13105	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EFI48_RS13105	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EFI48_RS13110	COG0527	aspartate kinase activity
EFI48_RS13120	COG1368	sulfuric ester hydrolase activity
EFI48_RS13125	COG1619	proteins homologs of microcin C7 resistance protein MccF
EFI48_RS13130	COG4667	esterase of the alpha-beta hydrolase superfamily
EFI48_RS13150	COG1648	precorrin-2 dehydrogenase activity
EFI48_RS13150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EFI48_RS13160	COG0393	Putative heavy-metal-binding
EFI48_RS13165	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EFI48_RS13170	COG0285	dihydrofolate synthase activity
EFI48_RS13175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EFI48_RS13180	COG0101	tRNA pseudouridine synthase activity
EFI48_RS13190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EFI48_RS13195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EFI48_RS13200	COG0671	phosphoesterase, PA-phosphatase related
EFI48_RS13205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EFI48_RS13210	COG2056	Na+-H+ antiporter family
EFI48_RS13215	COG3300	MHYT domain
EFI48_RS13215	COG5001	Diguanylate cyclase
EFI48_RS13230	COG2050	protein possibly involved in aromatic compounds catabolism
EFI48_RS13240	COG0247	lactate metabolic process
EFI48_RS13240	COG0277	FAD linked oxidase domain protein
EFI48_RS13250	COG1253	flavin adenine dinucleotide binding
EFI48_RS13255	COG1902	pentaerythritol trinitrate reductase activity
EFI48_RS13270	COG0647	UMP catabolic process
EFI48_RS13275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EFI48_RS13275	COG4651	solute:proton antiporter activity
EFI48_RS13285	COG0367	asparagine synthase
EFI48_RS13315	COG0322	excinuclease ABC activity
EFI48_RS13320	COG2197	response regulator
EFI48_RS13325	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EFI48_RS13330	COG2835	tetraacyldisaccharide 4'-kinase activity
EFI48_RS13335	COG1663	tetraacyldisaccharide 4'-kinase activity
EFI48_RS13345	COG2333	competence protein COMEC
EFI48_RS13345	COG0658	competence protein
EFI48_RS13360	COG1448	Aminotransferase
EFI48_RS13370	COG0583	DNA-binding transcription factor activity
EFI48_RS13375	COG3085	chromosome segregation
EFI48_RS13380	COG4574	serine-type endopeptidase inhibitor activity
EFI48_RS13385	COG0584	glycerophosphoryl diester phosphodiesterase
EFI48_RS13395	COG1349	DNA-binding transcription factor activity
EFI48_RS13400	COG2271	Major facilitator Superfamily
EFI48_RS13405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EFI48_RS13410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EFI48_RS13415	COG0840	transmembrane signaling receptor activity
EFI48_RS13425	COG0583	DNA-binding transcription factor activity
EFI48_RS13445	COG0656	L-ascorbic acid biosynthetic process
EFI48_RS13455	COG2814	Major facilitator Superfamily
EFI48_RS13460	COG2249	NAD(P)H dehydrogenase (quinone) activity
EFI48_RS13475	COG3220	belongs to the UPF0276 family
EFI48_RS13495	COG1294	oxidase, subunit
EFI48_RS13505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EFI48_RS13510	COG2979	Protein of unknown function (DUF533)
EFI48_RS13525	COG0583	DNA-binding transcription factor activity
EFI48_RS13530	COG2807	transmembrane transport
EFI48_RS13535	COG1187	pseudouridine synthase activity
EFI48_RS13545	COG0346	lactoylglutathione lyase activity
EFI48_RS13555	COG1403	HNH endonuclease
EFI48_RS13560	COG4657	Part of a membrane complex involved in electron transport
EFI48_RS13565	COG2878	Part of a membrane complex involved in electron transport
EFI48_RS13575	COG4658	electron transport chain
EFI48_RS13580	COG4659	FMN binding
EFI48_RS13585	COG4660	Part of a membrane complex involved in electron transport
EFI48_RS13590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EFI48_RS13595	COG0346	lactoylglutathione lyase activity
EFI48_RS13635	COG1199	ATP-dependent helicase activity
EFI48_RS13645	COG0123	including yeast histone deacetylase and acetoin utilization protein
EFI48_RS13650	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EFI48_RS13655	COG1785	Belongs to the alkaline phosphatase family
EFI48_RS13675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EFI48_RS13680	COG2197	response regulator
EFI48_RS13690	COG2271	Major facilitator Superfamily
EFI48_RS13695	COG3706	GGDEF domain
EFI48_RS13700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFI48_RS13705	COG0765	amino acid transport
EFI48_RS13710	COG1126	abc transporter atp-binding protein
EFI48_RS13725	COG0531	amino acid
EFI48_RS13745	COG1253	flavin adenine dinucleotide binding
EFI48_RS13750	COG0704	Plays a role in the regulation of phosphate uptake
EFI48_RS13755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EFI48_RS13760	COG0581	inorganic phosphate transmembrane transporter activity
EFI48_RS13765	COG0573	inorganic phosphate transmembrane transporter activity
EFI48_RS13770	COG0590	tRNA wobble adenosine to inosine editing
EFI48_RS13780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EFI48_RS13800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EFI48_RS13805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EFI48_RS13810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EFI48_RS13815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EFI48_RS13840	COG2716	regulation of RNA biosynthetic process
EFI48_RS13845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EFI48_RS13855	COG2239	Acts as a magnesium transporter
EFI48_RS13860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EFI48_RS13870	COG3951	Flagellar rod assembly protein muramidase FlgJ
EFI48_RS13870	COG1705	Flagellar rod assembly protein muramidase FlgJ
EFI48_RS13875	COG1706	bacterial-type flagellum-dependent cell motility
EFI48_RS13880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EFI48_RS13890	COG4787	bacterial-type flagellum-dependent cell motility
EFI48_RS13910	COG1815	bacterial-type flagellum-dependent cell motility
EFI48_RS13915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EFI48_RS13920	COG0835	chemotaxis
EFI48_RS13920	COG0784	Response regulator, receiver
EFI48_RS13925	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
EFI48_RS13940	COG0622	Phosphoesterase
EFI48_RS13945	COG4166	transmembrane transport
EFI48_RS13970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EFI48_RS13975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EFI48_RS13980	COG1882	Formate acetyltransferase
EFI48_RS13985	COG1349	DNA-binding transcription factor activity
EFI48_RS13990	COG4166	transmembrane transport
EFI48_RS14015	COG1278	Cold shock
EFI48_RS14040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EFI48_RS14040	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EFI48_RS14045	COG1028	Short-chain dehydrogenase reductase Sdr
EFI48_RS14050	COG3433	isochorismatase activity
EFI48_RS14050	COG1535	isochorismatase
EFI48_RS14055	COG1021	2,3-dihydroxybenzoate-AMP ligase
EFI48_RS14060	COG1169	isochorismate synthase
EFI48_RS14065	COG4771	TonB-dependent receptor
EFI48_RS14070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EFI48_RS14075	COG1609	Transcriptional regulator
EFI48_RS14080	COG0741	lytic transglycosylase activity
EFI48_RS14090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EFI48_RS14110	COG2911	Protein conserved in bacteria
EFI48_RS14115	COG0729	surface antigen
EFI48_RS14125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EFI48_RS14135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EFI48_RS14145	COG4134	Bacterial extracellular solute-binding protein
EFI48_RS14155	COG4136	ATPase activity
EFI48_RS14160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EFI48_RS14165	COG2951	lytic endotransglycosylase activity
EFI48_RS14170	COG1846	Transcriptional regulator
EFI48_RS14180	COG0033	Phosphoglucomutase
EFI48_RS14185	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EFI48_RS14190	COG0596	Alpha beta hydrolase
EFI48_RS14205	COG0716	FMN binding
EFI48_RS14215	COG0735	belongs to the Fur family
EFI48_RS14220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EFI48_RS14230	COG2190	(PTS) system
EFI48_RS14230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EFI48_RS14230	COG1263	PTS System
EFI48_RS14235	COG0363	glucosamine-6-phosphate deaminase activity
EFI48_RS14240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EFI48_RS14245	COG1940	carbohydrate kinase activity
EFI48_RS14245	COG1846	Transcriptional regulator
EFI48_RS14250	COG2194	sulfuric ester hydrolase activity
EFI48_RS14255	COG2199	diguanylate cyclase activity
EFI48_RS14255	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EFI48_RS14260	COG3275	phosphorelay sensor kinase activity
EFI48_RS14265	COG3279	Response regulator of the LytR AlgR family
EFI48_RS14270	COG1966	Carbon starvation protein
EFI48_RS14280	COG1566	PFAM secretion protein HlyD family protein
EFI48_RS14285	COG1061	Type III restriction enzyme res subunit
EFI48_RS14290	COG2027	D-alanyl-D-alanine carboxypeptidase
EFI48_RS14295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EFI48_RS14300	COG3021	interspecies interaction between organisms
EFI48_RS14310	COG1607	acyl-coa hydrolase
EFI48_RS14315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EFI48_RS14320	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EFI48_RS14320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EFI48_RS14320	COG1013	pyruvate-flavodoxin oxidoreductase activity
EFI48_RS14320	COG0674	pyruvate-flavodoxin oxidoreductase activity
EFI48_RS14335	COG0633	Ferredoxin
EFI48_RS14335	COG3217	Mosc domain protein beta barrel domain protein
EFI48_RS14335	COG0633	Ferredoxin
EFI48_RS14335	COG3217	Mosc domain protein beta barrel domain protein
EFI48_RS14345	COG0501	Belongs to the peptidase M48B family
EFI48_RS14350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EFI48_RS14355	COG1073	alpha beta
EFI48_RS14355	COG2226	methyltransferase
EFI48_RS14360	COG0156	8-amino-7-oxononanoate synthase activity
EFI48_RS14365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EFI48_RS14370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EFI48_RS14385	COG0017	Asparaginyl-tRNA synthetase
EFI48_RS14395	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EFI48_RS14405	COG1473	amidohydrolase
EFI48_RS14410	COG3069	C4-dicarboxylate transmembrane transporter activity
EFI48_RS14420	COG1393	Belongs to the ArsC family
EFI48_RS14425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EFI48_RS14430	COG1876	peptidase activity
EFI48_RS14440	COG3263	regulation of cellular component size
EFI48_RS14455	COG1280	lysine exporter protein (LysE YggA)
EFI48_RS14485	COG0564	pseudouridine synthase activity
EFI48_RS14495	COG1454	alcohol dehydrogenase
EFI48_RS14535	COG2894	cell division
EFI48_RS14545	COG4964	Belongs to the GSP D family
EFI48_RS14575	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EFI48_RS14580	COG0702	epimerase
EFI48_RS14590	COG0095	Lipoate-protein ligase
EFI48_RS14600	COG1136	(ABC) transporter
EFI48_RS14600	COG0577	efflux transmembrane transporter activity
EFI48_RS14605	COG1136	(ABC) transporter
EFI48_RS14605	COG0577	efflux transmembrane transporter activity
EFI48_RS14610	COG0577	efflux transmembrane transporter activity
EFI48_RS14610	COG1136	(ABC) transporter
EFI48_RS14615	COG1566	PFAM secretion protein HlyD family protein
EFI48_RS14650	COG0446	pyridine nucleotide-disulphide oxidoreductase
EFI48_RS14660	COG1285	pathogenesis
EFI48_RS14690	COG0484	heat shock protein binding
EFI48_RS14695	COG0443	Heat shock 70 kDa protein
EFI48_RS14700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EFI48_RS14705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EFI48_RS14710	COG0497	DNA recombination
EFI48_RS14715	COG1227	inorganic diphosphatase activity
EFI48_RS14720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EFI48_RS14725	COG0577	efflux transmembrane transporter activity
EFI48_RS14725	COG1136	(ABC) transporter
EFI48_RS14745	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EFI48_RS14765	COG0489	protein tyrosine kinase activity
EFI48_RS14765	COG3206	protein involved in exopolysaccharide biosynthesis
EFI48_RS14770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EFI48_RS14775	COG1596	polysaccharide export
EFI48_RS14795	COG1216	Glycosyl transferase, family 2
EFI48_RS14805	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EFI48_RS14830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EFI48_RS14855	COG1216	Glycosyl transferase, family 2
EFI48_RS14855	COG0463	Glycosyl transferase, family 2
EFI48_RS14875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EFI48_RS14900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EFI48_RS14905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EFI48_RS14910	COG1309	transcriptional regulator
EFI48_RS14925	COG1342	Belongs to the UPF0251 family
EFI48_RS14945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EFI48_RS14970	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EFI48_RS14975	COG0083	homoserine kinase activity
EFI48_RS14990	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EFI48_RS14995	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EFI48_RS15000	COG1946	Acyl-CoA thioesterase
EFI48_RS15015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EFI48_RS15025	COG0009	L-threonylcarbamoyladenylate synthase
EFI48_RS15035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EFI48_RS15040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EFI48_RS15040	COG0512	Glutamine amidotransferase of anthranilate synthase
EFI48_RS15045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EFI48_RS15050	COG0135	phosphoribosylanthranilate isomerase activity
EFI48_RS15050	COG0134	indole-3-glycerol-phosphate synthase activity
EFI48_RS15055	COG0133	tryptophan synthase activity
EFI48_RS15060	COG0159	tryptophan synthase activity
EFI48_RS15095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EFI48_RS15105	COG0798	PFAM Bile acid sodium symporter
EFI48_RS15135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EFI48_RS15145	COG0745	RESPONSE REGULATOR receiver
EFI48_RS15160	COG4988	ABC transporter
EFI48_RS15165	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EFI48_RS15185	COG1720	tRNA m6t6A37 methyltransferase activity
EFI48_RS15190	COG3038	cytochrome b561
EFI48_RS15230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EFI48_RS15235	COG1396	sequence-specific DNA binding
EFI48_RS15235	COG1917	Cupin 2, conserved barrel domain protein
EFI48_RS15250	COG0531	amino acid
EFI48_RS15260	COG0531	amino acid
EFI48_RS15265	COG1283	sodium-dependent phosphate transmembrane transporter activity
EFI48_RS15275	COG0405	Gamma-glutamyltransferase
EFI48_RS15280	COG2974	May be involved in recombination
EFI48_RS15290	COG0420	3'-5' exonuclease activity
EFI48_RS15295	COG0419	ATPase involved in DNA repair
EFI48_RS15310	COG0469	pyruvate kinase activity
EFI48_RS15315	COG1196	nuclear chromosome segregation
EFI48_RS15315	COG3264	Mechanosensitive ion channel
EFI48_RS15325	COG3590	peptidase
EFI48_RS15335	COG2190	(PTS) system
EFI48_RS15345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFI48_RS15350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EFI48_RS15355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EFI48_RS15370	COG3437	response regulator, receiver
EFI48_RS15370	COG2770	Histidine kinase
EFI48_RS15375	COG3409	Peptidoglycan-binding domain 1 protein
EFI48_RS15375	COG3267	Type II secretory pathway component ExeA
EFI48_RS15385	COG3031	protein transport across the cell outer membrane
EFI48_RS15395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EFI48_RS15400	COG1459	type II secretion system
EFI48_RS15405	COG2165	general secretion pathway protein
EFI48_RS15415	COG2165	general secretion pathway protein
EFI48_RS15420	COG4795	General secretion pathway protein
EFI48_RS15425	COG3156	type II secretion system protein K
EFI48_RS15435	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EFI48_RS15450	COG0670	Belongs to the BI1 family
EFI48_RS15455	COG1289	transmembrane transporter activity
EFI48_RS15460	COG2920	part of a sulfur-relay system
EFI48_RS15465	COG0673	inositol 2-dehydrogenase activity
EFI48_RS15470	COG0583	DNA-binding transcription factor activity
EFI48_RS15490	COG5433	transposase activity
EFI48_RS15495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EFI48_RS15500	COG1032	radical SAM domain protein
EFI48_RS15510	COG1566	PFAM secretion protein HlyD family protein
EFI48_RS15520	COG1752	Esterase of the alpha-beta hydrolase superfamily
EFI48_RS15525	COG0531	amino acid
EFI48_RS15560	COG0281	malic enzyme
EFI48_RS15570	COG0534	Mate efflux family protein
EFI48_RS15585	COG2233	PERMEase
EFI48_RS15590	COG0095	Lipoate-protein ligase
EFI48_RS15595	COG1115	amino acid carrier protein
EFI48_RS15600	COG0019	diaminopimelate decarboxylase activity
EFI48_RS15610	COG0678	peroxiredoxin activity
EFI48_RS15635	COG0545	Peptidyl-prolyl cis-trans isomerase
EFI48_RS15640	COG3142	Participates in the control of copper homeostasis
EFI48_RS15665	COG5002	protein histidine kinase activity
EFI48_RS15670	COG0745	RESPONSE REGULATOR receiver
EFI48_RS15675	COG0346	lactoylglutathione lyase activity
EFI48_RS15680	COG3284	Transcriptional regulator
EFI48_RS15695	COG0697	spore germination
EFI48_RS15705	COG3290	protein histidine kinase activity
EFI48_RS15710	COG0281	malic enzyme
EFI48_RS15725	COG1846	Transcriptional regulator
EFI48_RS15760	COG0602	queuosine metabolic process
EFI48_RS15765	COG1328	CTP reductase activity
EFI48_RS15775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EFI48_RS15780	COG3115	cell septum assembly
EFI48_RS15785	COG1196	nuclear chromosome segregation
EFI48_RS15795	COG2860	membrane
EFI48_RS15805	COG3108	Peptidase M15
EFI48_RS15810	COG2989	Protein conserved in bacteria
EFI48_RS15825	COG0463	Glycosyl transferase, family 2
EFI48_RS15840	COG0366	Alpha amylase catalytic
EFI48_RS15875	COG2199	diguanylate cyclase activity
EFI48_RS15875	COG2203	Gaf domain
EFI48_RS15885	COG3590	peptidase
EFI48_RS15895	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EFI48_RS15900	COG1982	Orn Lys Arg decarboxylase major
EFI48_RS15905	COG0531	amino acid
EFI48_RS15910	COG3710	Transcriptional regulator
EFI48_RS15915	COG0531	amino acid
EFI48_RS15940	COG0814	amino acid
EFI48_RS15970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EFI48_RS15975	COG0739	heme binding
EFI48_RS15980	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EFI48_RS15995	COG0251	oxidation-reduction process
EFI48_RS16010	COG0583	DNA-binding transcription factor activity
EFI48_RS16015	COG0604	alcohol dehydrogenase
EFI48_RS16015	COG1028	Short-chain dehydrogenase reductase Sdr
EFI48_RS16015	COG3321	synthase
EFI48_RS16025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EFI48_RS16035	COG3091	SprT-like family
EFI48_RS16045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EFI48_RS16050	COG0189	ligase activity
EFI48_RS16055	COG1678	Uncharacterized ACR, COG1678
EFI48_RS16060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EFI48_RS16080	COG5433	transposase activity
EFI48_RS16090	COG2814	Major facilitator Superfamily
EFI48_RS16095	COG0714	Associated with various cellular activities
EFI48_RS16110	COG1115	amino acid carrier protein
EFI48_RS16115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EFI48_RS16125	COG0825	malonyl-CoA metabolic process
EFI48_RS16135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EFI48_RS16140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EFI48_RS16145	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EFI48_RS16150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EFI48_RS16155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EFI48_RS16165	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EFI48_RS16170	COG0750	zinc metalloprotease
EFI48_RS16175	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EFI48_RS16180	COG0575	Belongs to the CDS family
EFI48_RS16185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EFI48_RS16190	COG0233	cytoplasmic translational termination
EFI48_RS16195	COG0528	UMP kinase activity
EFI48_RS16200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EFI48_RS16205	COG0052	Belongs to the universal ribosomal protein uS2 family
EFI48_RS16210	COG0024	Methionine aminopeptidase
EFI48_RS16220	COG2171	N-acyltransferase activity
EFI48_RS16230	COG1263	PTS System
EFI48_RS16230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EFI48_RS16240	COG4580	involved in the transport of maltose and maltodextrins
EFI48_RS16250	COG0564	pseudouridine synthase activity
EFI48_RS16255	COG3098	single-species biofilm formation
EFI48_RS16280	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EFI48_RS16290	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EFI48_RS16290	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EFI48_RS16305	COG1611	Belongs to the LOG family
EFI48_RS16310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EFI48_RS16315	COG0473	3-isopropylmalate dehydrogenase activity
EFI48_RS16325	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EFI48_RS16330	COG2363	Small membrane protein
EFI48_RS16340	COG0583	DNA-binding transcription factor activity
EFI48_RS16345	COG0840	transmembrane signaling receptor activity
EFI48_RS16350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EFI48_RS16365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EFI48_RS16370	COG1666	GTP binding
EFI48_RS16380	COG2211	Major facilitator Superfamily
EFI48_RS16385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EFI48_RS16395	COG2813	Specifically methylates the guanine in position
EFI48_RS16400	COG0271	Belongs to the BolA IbaG family
EFI48_RS16405	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EFI48_RS16410	COG1805	sodium ion transport
EFI48_RS16415	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EFI48_RS16420	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EFI48_RS16425	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EFI48_RS16430	COG2871	sodium ion transport
EFI48_RS16435	COG1477	protein flavinylation
EFI48_RS16465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EFI48_RS16480	COG0300	oxidoreductase activity
EFI48_RS16490	COG0415	Belongs to the DNA photolyase family
EFI48_RS16495	COG0789	Transcriptional regulator
EFI48_RS16500	COG3272	Protein of unknown function (DUF1722)
EFI48_RS16530	COG0077	Prephenate dehydratase
EFI48_RS16530	COG1605	Chorismate mutase
EFI48_RS16560	COG0840	transmembrane signaling receptor activity
EFI48_RS16570	COG0300	oxidoreductase activity
EFI48_RS16595	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EFI48_RS16635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EFI48_RS16640	COG0826	peptidase U32
EFI48_RS16645	COG1280	lysine exporter protein (LysE YggA)
EFI48_RS16655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EFI48_RS16665	COG0745	RESPONSE REGULATOR receiver
EFI48_RS16675	COG0643	Histidine kinase
EFI48_RS16675	COG2198	Histidine kinase
EFI48_RS16685	COG0835	chemotaxis
EFI48_RS16690	COG0840	transmembrane signaling receptor activity
EFI48_RS16700	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EFI48_RS16705	COG2201	protein-glutamate methylesterase activity
EFI48_RS16710	COG1185	polyribonucleotide nucleotidyltransferase activity
EFI48_RS16715	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EFI48_RS16720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EFI48_RS16725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EFI48_RS16730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EFI48_RS16735	COG0195	Participates in both transcription termination and antitermination
EFI48_RS16740	COG0779	Required for maturation of 30S ribosomal subunits
EFI48_RS16755	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EFI48_RS16760	COG0149	triose-phosphate isomerase activity
EFI48_RS16765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EFI48_RS16770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EFI48_RS16780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EFI48_RS16785	COG1534	Rna-binding protein
EFI48_RS16800	COG1360	Flagellar Motor Protein
EFI48_RS16805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EFI48_RS16810	COG1722	exodeoxyribonuclease VII activity
EFI48_RS16815	COG0142	geranyltranstransferase activity
EFI48_RS16820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EFI48_RS16825	COG0737	Belongs to the 5'-nucleotidase family
EFI48_RS16845	COG2204	response regulator
EFI48_RS16850	COG0545	Peptidyl-prolyl cis-trans isomerase
EFI48_RS16860	COG2900	Belongs to the SlyX family
EFI48_RS16870	COG0601	transmembrane transport
EFI48_RS16885	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EFI48_RS16890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EFI48_RS16895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EFI48_RS16900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EFI48_RS16915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EFI48_RS16915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EFI48_RS16920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EFI48_RS16925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EFI48_RS16935	COG2205	protein histidine kinase activity
EFI48_RS16935	COG2198	Histidine kinase
EFI48_RS16935	COG0784	Response regulator, receiver
EFI48_RS16940	COG1879	ABC-type sugar transport system periplasmic component
EFI48_RS16950	COG0745	RESPONSE REGULATOR receiver
EFI48_RS16955	COG3005	denitrification pathway
EFI48_RS16965	COG3381	protein complex oligomerization
EFI48_RS16985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EFI48_RS16990	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EFI48_RS16995	COG0511	ligase activity, forming carbon-carbon bonds
EFI48_RS17000	COG0439	Biotin carboxylase
EFI48_RS17005	COG3924	membrane
EFI48_RS17010	COG4145	pantothenate transmembrane transporter activity
EFI48_RS17015	COG2190	(PTS) system
EFI48_RS17015	COG1263	PTS System
EFI48_RS17015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EFI48_RS17020	COG0583	DNA-binding transcription factor activity
EFI48_RS17025	COG0604	alcohol dehydrogenase
EFI48_RS17030	COG2264	protein methyltransferase activity
EFI48_RS17040	COG0778	Nitroreductase
EFI48_RS17045	COG0446	pyridine nucleotide-disulphide oxidoreductase
EFI48_RS17045	COG1902	pentaerythritol trinitrate reductase activity
EFI48_RS17050	COG0616	signal peptide processing
EFI48_RS17070	COG0848	biopolymer transport protein
EFI48_RS17075	COG0811	peptide transport
EFI48_RS17080	COG0811	peptide transport
EFI48_RS17095	COG4174	ABC transporter (Permease)
EFI48_RS17100	COG4239	(ABC) transporter, permease
EFI48_RS17110	COG0444	Belongs to the ABC transporter superfamily
EFI48_RS17115	COG4608	Belongs to the ABC transporter superfamily
EFI48_RS17135	COG3416	Protein conserved in bacteria
EFI48_RS17145	COG0741	lytic transglycosylase activity
EFI48_RS17160	COG0488	(ABC) transporter
EFI48_RS17170	COG2252	PERMEase
EFI48_RS17175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EFI48_RS17180	COG0840	transmembrane signaling receptor activity
EFI48_RS17190	COG1278	Cold shock
EFI48_RS17230	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EFI48_RS17235	COG1162	GTPase activity
EFI48_RS17240	COG0688	phosphatidylethanolamine metabolic process
EFI48_RS17245	COG4628	conserved protein (DUF2132)
EFI48_RS17260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EFI48_RS17275	COG1073	alpha beta
EFI48_RS17280	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EFI48_RS17290	COG2195	Cleaves the N-terminal amino acid of tripeptides
EFI48_RS17295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EFI48_RS17300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EFI48_RS17305	COG3178	'Phosphotransferase
EFI48_RS17310	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EFI48_RS17315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EFI48_RS17320	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EFI48_RS17325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EFI48_RS17330	COG2967	ApaG domain
EFI48_RS17335	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EFI48_RS17350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFI48_RS17360	COG3314	Sporulation integral membrane protein YlbJ
EFI48_RS17365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EFI48_RS17370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EFI48_RS17375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EFI48_RS17380	COG0142	geranyltranstransferase activity
EFI48_RS17385	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EFI48_RS17390	COG0330	HflC and HflK could
EFI48_RS17395	COG0330	HflC and HflK could
EFI48_RS17400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EFI48_RS17405	COG1923	regulation of RNA biosynthetic process
EFI48_RS17410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EFI48_RS17415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EFI48_RS17420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EFI48_RS17430	COG0802	atpase or kinase
EFI48_RS17435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EFI48_RS17435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EFI48_RS17455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EFI48_RS17460	COG2011	ABC-type metal ion transport system permease component
EFI48_RS17465	COG1464	Belongs to the NlpA lipoprotein family
EFI48_RS17500	COG0784	Response regulator, receiver
EFI48_RS17500	COG5002	protein histidine kinase activity
EFI48_RS17500	COG2198	Histidine kinase
EFI48_RS17535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EFI48_RS17540	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EFI48_RS17545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EFI48_RS17550	COG2716	regulation of RNA biosynthetic process
EFI48_RS17555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EFI48_RS17560	COG3013	Belongs to the UPF0304 family
EFI48_RS17570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EFI48_RS17575	COG0857	belongs to the CobB CobQ family
EFI48_RS17575	COG0280	phosphate acetyltransferase
EFI48_RS17580	COG1555	photosystem II stabilization
EFI48_RS17585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EFI48_RS17590	COG3104	oligopeptide transport
EFI48_RS17595	COG0745	RESPONSE REGULATOR receiver
EFI48_RS17625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EFI48_RS17640	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EFI48_RS17685	COG0582	viral genome integration into host DNA
EFI48_RS17720	COG0440	acetolactate synthase activity
EFI48_RS17725	COG0028	Belongs to the TPP enzyme family
EFI48_RS17750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EFI48_RS17755	COG0473	3-isopropylmalate dehydrogenase activity
EFI48_RS17760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EFI48_RS17765	COG0066	3-isopropylmalate dehydratase activity
EFI48_RS17780	COG4143	(ABC) transporter
EFI48_RS17785	COG1178	ABC-type Fe3 transport system permease component
EFI48_RS17790	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EFI48_RS17795	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EFI48_RS17845	COG0459	protein refolding
EFI48_RS17850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EFI48_RS17860	COG0534	Mate efflux family protein
EFI48_RS17865	COG3030	protein affecting phage T7 exclusion by the F plasmid
EFI48_RS17870	COG1027	Aspartate ammonia-lyase
EFI48_RS17875	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EFI48_RS17880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EFI48_RS17885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EFI48_RS17890	COG1610	YqeY-like protein
EFI48_RS17895	COG0358	DNA primase activity
EFI48_RS17900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EFI48_RS17920	COG0151	Belongs to the GarS family
EFI48_RS17925	COG0138	bifunctional purine biosynthesis protein purh
EFI48_RS17935	COG3036	rescue of stalled ribosome
EFI48_RS17940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EFI48_RS17945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EFI48_RS17955	COG0673	inositol 2-dehydrogenase activity
EFI48_RS17965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EFI48_RS17970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EFI48_RS17980	COG0583	DNA-binding transcription factor activity
EFI48_RS17985	COG0477	Major facilitator Superfamily
EFI48_RS18005	COG1028	Short-chain dehydrogenase reductase Sdr
EFI48_RS18015	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EFI48_RS18030	COG0456	acetyltransferase
EFI48_RS18040	COG1022	Amp-dependent synthetase and ligase
EFI48_RS18050	COG2918	glutathione biosynthetic process
EFI48_RS18055	COG0612	Peptidase, M16
EFI48_RS18060	COG1238	metal cluster binding
EFI48_RS18065	COG1064	alcohol dehydrogenase
EFI48_RS18090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EFI48_RS18095	COG0359	binds to the 23S rRNA
EFI48_RS18100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EFI48_RS18105	COG0360	Binds together with S18 to 16S ribosomal RNA
EFI48_RS18110	COG1914	H( )-stimulated, divalent metal cation uptake system
EFI48_RS18115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EFI48_RS18125	COG0776	regulation of translation
EFI48_RS18140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EFI48_RS18155	COG0560	Phosphoserine phosphatase
EFI48_RS18165	COG0813	purine-nucleoside phosphorylase activity
EFI48_RS18170	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EFI48_RS18175	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EFI48_RS18180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EFI48_RS18190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EFI48_RS18195	COG0084	hydrolase, TatD family'
EFI48_RS18200	COG2165	general secretion pathway protein
EFI48_RS18210	COG1854	S-ribosylhomocysteine lyase activity
EFI48_RS18225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EFI48_RS18225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EFI48_RS18285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EFI48_RS18290	COG1047	Peptidyl-prolyl cis-trans
EFI48_RS18295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EFI48_RS18300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EFI48_RS18305	COG0196	riboflavin kinase activity
EFI48_RS18310	COG0728	peptidoglycan biosynthetic process
EFI48_RS18315	COG0268	Binds directly to 16S ribosomal RNA
EFI48_RS18320	COG0640	Transcriptional regulator
EFI48_RS18325	COG0583	DNA-binding transcription factor activity
EFI48_RS18335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EFI48_RS18340	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EFI48_RS18345	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EFI48_RS18355	COG1051	belongs to the nudix hydrolase family
EFI48_RS18360	COG3066	DNA modification
EFI48_RS18370	COG0335	large ribosomal subunit rRNA binding
EFI48_RS18375	COG0336	Belongs to the RNA methyltransferase TrmD family
EFI48_RS18380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EFI48_RS18385	COG0228	four-way junction DNA binding
EFI48_RS18390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EFI48_RS18395	COG4137	Cytochrome C assembly protein
EFI48_RS18400	COG4536	flavin adenine dinucleotide binding
EFI48_RS18410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EFI48_RS18410	COG1017	nitric oxide dioxygenase activity
EFI48_RS18415	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EFI48_RS18420	COG0039	L-malate dehydrogenase activity
EFI48_RS18425	COG4160	amino acid transport
EFI48_RS18430	COG4215	(ABC) transporter
EFI48_RS18435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFI48_RS18440	COG1126	abc transporter atp-binding protein
EFI48_RS18445	COG1438	arginine binding
EFI48_RS18450	COG2837	iron assimilation
EFI48_RS18455	COG3842	ATPase activity
EFI48_RS18465	COG1840	ABC-type Fe3 transport system, periplasmic component
EFI48_RS18475	COG0347	Belongs to the P(II) protein family
EFI48_RS18495	COG3022	response to hydroperoxide
EFI48_RS18510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EFI48_RS18515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EFI48_RS18520	COG0762	integral membrane protein
EFI48_RS18525	COG1872	DUF167
EFI48_RS18535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EFI48_RS18540	COG0583	DNA-binding transcription factor activity
EFI48_RS18555	COG1929	Belongs to the glycerate kinase type-1 family
EFI48_RS18560	COG2610	gluconate transmembrane transporter activity
EFI48_RS18565	COG3835	regulator
EFI48_RS18570	COG3112	Uncharacterised protein family (UPF0231)
EFI48_RS18590	COG3568	Endonuclease Exonuclease Phosphatase
EFI48_RS18600	COG0513	Belongs to the DEAD box helicase family
EFI48_RS18640	COG1448	Aminotransferase
EFI48_RS18660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EFI48_RS18665	COG1328	CTP reductase activity
EFI48_RS18690	COG0543	2 iron, 2 sulfur cluster binding
EFI48_RS18690	COG0633	Ferredoxin
EFI48_RS18705	COG1215	transferase activity, transferring glycosyl groups
EFI48_RS18710	COG1649	PFAM Uncharacterised BCR, COG1649
EFI48_RS18710	COG0726	polysaccharide deacetylase
EFI48_RS18725	COG0840	transmembrane signaling receptor activity
EFI48_RS18730	COG3397	chitin binding
EFI48_RS18735	COG0583	DNA-binding transcription factor activity
EFI48_RS18740	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EFI48_RS18745	COG4208	sulfate ABC transporter
EFI48_RS18750	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EFI48_RS18760	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EFI48_RS18765	COG3174	membrane
EFI48_RS18770	COG0110	maltose O-acetyltransferase activity
EFI48_RS18785	COG1011	Hydrolase
EFI48_RS18790	COG0494	nUDIX hydrolase
EFI48_RS18795	COG1218	3'(2'),5'-bisphosphate nucleotidase
EFI48_RS18800	COG0814	amino acid
EFI48_RS18805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EFI48_RS18820	COG0626	cystathionine gamma-synthase activity
EFI48_RS18825	COG0460	homoserine dehydrogenase
EFI48_RS18825	COG0527	aspartate kinase activity
EFI48_RS18830	COG0306	phosphate transporter
EFI48_RS18835	COG1392	Phosphate transport regulator
EFI48_RS18845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EFI48_RS18850	COG2813	Specifically methylates the guanine in position
EFI48_RS18855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EFI48_RS18860	COG0297	glycogen (starch) synthase activity
EFI48_RS18900	COG1757	Na H antiporter
EFI48_RS18905	COG0316	Belongs to the HesB IscA family
EFI48_RS18915	COG0038	chloride channel
EFI48_RS18920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EFI48_RS18935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EFI48_RS18935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EFI48_RS18970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EFI48_RS18975	COG0564	pseudouridine synthase activity
EFI48_RS18990	COG0110	maltose O-acetyltransferase activity
EFI48_RS18995	COG0366	Alpha amylase catalytic
EFI48_RS19000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EFI48_RS19000	COG1263	PTS System
EFI48_RS19020	COG0252	asparaginase activity
EFI48_RS19025	COG1253	flavin adenine dinucleotide binding
EFI48_RS19030	COG0586	Pfam SNARE associated Golgi protein
EFI48_RS19035	COG1686	Belongs to the peptidase S11 family
EFI48_RS19070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EFI48_RS19075	COG0527	aspartate kinase activity
EFI48_RS19080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EFI48_RS19090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EFI48_RS19095	COG1546	Belongs to the CinA family
EFI48_RS19105	COG5377	YqaJ viral recombinase family
EFI48_RS19150	COG2003	Belongs to the UPF0758 family
EFI48_RS19175	COG4667	esterase of the alpha-beta hydrolase superfamily
EFI48_RS19180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EFI48_RS19185	COG0582	viral genome integration into host DNA
EFI48_RS19210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EFI48_RS19255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EFI48_RS19295	COG1346	cytolysis
EFI48_RS19305	COG0583	DNA-binding transcription factor activity
EFI48_RS19325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EFI48_RS19345	COG2856	Zn peptidase
EFI48_RS19355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EFI48_RS19360	COG2022	thiamine diphosphate biosynthetic process
EFI48_RS19370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EFI48_RS19375	COG0352	thiamine-phosphate diphosphorylase activity
EFI48_RS19380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EFI48_RS19400	COG0745	RESPONSE REGULATOR receiver
EFI48_RS19405	COG0642	Histidine kinase
EFI48_RS19410	COG0189	ligase activity
EFI48_RS19460	COG0477	Major facilitator Superfamily
EFI48_RS19475	COG0312	modulator of DNA gyrase
EFI48_RS19480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EFI48_RS19490	COG3164	Protein of unknown function
EFI48_RS19495	COG1530	ribonuclease E activity
EFI48_RS19500	COG0424	maF-like protein
EFI48_RS19505	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EFI48_RS19510	COG1792	Involved in formation and maintenance of cell shape
EFI48_RS19515	COG1077	Cell shape determining protein MreB Mrl
EFI48_RS19540	COG4968	Prepilin-type N-terminal cleavage methylation domain
EFI48_RS19545	COG2165	general secretion pathway protein
EFI48_RS19560	COG1459	type II secretion system
EFI48_RS19565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EFI48_RS19610	COG2200	EAL domain
EFI48_RS19610	COG2199	diguanylate cyclase activity
EFI48_RS19615	COG2200	EAL domain
EFI48_RS19620	COG0387	Pfam Sodium calcium exchanger
EFI48_RS19625	COG2986	histidine ammonia-lyase
EFI48_RS19630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EFI48_RS19635	COG0010	Belongs to the arginase family
EFI48_RS19640	COG1228	amidohydrolase
EFI48_RS19645	COG2188	Transcriptional regulator
EFI48_RS19650	COG0288	reversible hydration of carbon dioxide
EFI48_RS19660	COG2177	Part of the ABC transporter FtsEX involved in
EFI48_RS19665	COG2884	Cell division ATP-binding protein ftsE
EFI48_RS19670	COG0552	protein localization to endoplasmic reticulum
EFI48_RS19675	COG0742	ribosomal rna small subunit methyltransferase
EFI48_RS19700	COG2249	NAD(P)H dehydrogenase (quinone) activity
EFI48_RS19705	COG0583	DNA-binding transcription factor activity
EFI48_RS19710	COG4221	oxidoreductase activity
EFI48_RS19725	COG1770	oligopeptidase
EFI48_RS19740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EFI48_RS19745	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EFI48_RS19755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EFI48_RS19765	COG2095	MarC family integral membrane protein
EFI48_RS19775	COG1301	dicarboxylic acid transport
EFI48_RS19800	COG3714	YhhN family
EFI48_RS19850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EFI48_RS19855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EFI48_RS19860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EFI48_RS19865	COG0049	tRNA binding
EFI48_RS19870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EFI48_RS19875	COG2168	tRNA wobble position uridine thiolation
EFI48_RS19885	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EFI48_RS19895	COG2964	Protein conserved in bacteria
EFI48_RS19900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EFI48_RS19905	COG0085	RNA polymerase activity
EFI48_RS19910	COG0222	ribosome binding
EFI48_RS19915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EFI48_RS19920	COG0081	regulation of translation
EFI48_RS19925	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EFI48_RS19930	COG0250	Participates in transcription elongation, termination and antitermination
EFI48_RS19945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EFI48_RS19970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EFI48_RS19975	COG0569	domain protein
EFI48_RS19980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EFI48_RS20010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFI48_RS20010	COG4191	Histidine kinase
EFI48_RS20015	COG3005	denitrification pathway
EFI48_RS20020	COG0243	molybdopterin cofactor binding
EFI48_RS20070	COG2204	response regulator
EFI48_RS20080	COG2205	protein histidine kinase activity
EFI48_RS20095	COG1028	Short-chain dehydrogenase reductase Sdr
EFI48_RS20100	COG0516	GMP reductase activity
EFI48_RS20100	COG0517	IMP dehydrogenase activity
EFI48_RS20105	COG5413	integral membrane protein
EFI48_RS20115	COG1522	sequence-specific DNA binding
EFI48_RS20120	COG2502	aspartate--ammonia ligase
EFI48_RS20125	COG0542	response to heat
EFI48_RS20135	COG0564	pseudouridine synthase activity
EFI48_RS20140	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EFI48_RS20145	COG0446	pyridine nucleotide-disulphide oxidoreductase
EFI48_RS20155	COG3681	Belongs to the UPF0597 family
EFI48_RS20160	COG2964	Protein conserved in bacteria
EFI48_RS20170	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EFI48_RS20175	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EFI48_RS20180	COG1979	alcohol dehydrogenase
EFI48_RS20185	COG2207	Transcriptional regulator
EFI48_RS20205	COG0583	DNA-binding transcription factor activity
EFI48_RS20220	COG0540	Belongs to the ATCase OTCase family
EFI48_RS20225	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EFI48_RS20230	COG1438	arginine binding
EFI48_RS20235	COG1288	antiporter activity
EFI48_RS20240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EFI48_RS20265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EFI48_RS20275	COG3078	GTPase activator activity
EFI48_RS20290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EFI48_RS20300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EFI48_RS20305	COG0408	coproporphyrinogen oxidase activity
EFI48_RS20310	COG0009	L-threonylcarbamoyladenylate synthase
EFI48_RS20320	COG0551	DNA topoisomerase type I activity
EFI48_RS20325	COG2922	Belongs to the Smg family
EFI48_RS20330	COG0758	DNA mediated transformation
EFI48_RS20335	COG1652	LysM domain
EFI48_RS20340	COG0242	peptide deformylase activity
EFI48_RS20345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EFI48_RS20350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EFI48_RS20350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EFI48_RS20355	COG0569	domain protein
EFI48_RS20360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EFI48_RS20365	COG1217	gtp-binding protein TYPA
EFI48_RS20370	COG0174	glutamine synthetase
EFI48_RS20385	COG2204	response regulator
EFI48_RS20390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EFI48_RS20395	COG1322	Protein conserved in bacteria
EFI48_RS20415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EFI48_RS20420	COG0583	DNA-binding transcription factor activity
EFI48_RS20425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EFI48_RS20425	COG0519	Catalyzes the synthesis of GMP from XMP
EFI48_RS20435	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EFI48_RS20440	COG1396	sequence-specific DNA binding
EFI48_RS20445	COG1012	belongs to the aldehyde dehydrogenase family
EFI48_RS20455	COG2962	Rard protein
EFI48_RS20460	COG0840	transmembrane signaling receptor activity
EFI48_RS20465	COG2391	methyltransferase activity
EFI48_RS20480	COG0129	dihydroxy-acid dehydratase activity
EFI48_RS20490	COG3978	acetolactate synthase activity
EFI48_RS20505	COG0606	chelatase, subunit chli
EFI48_RS20510	COG0204	Acyl-transferase
EFI48_RS20515	COG0204	Acyl-transferase
EFI48_RS20520	COG1683	Conserved Protein
EFI48_RS20530	COG1335	isochorismatase
EFI48_RS20540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EFI48_RS20545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EFI48_RS20555	COG3084	Protein conserved in bacteria
EFI48_RS20560	COG2203	Gaf domain
EFI48_RS20560	COG3706	GGDEF domain
EFI48_RS20560	COG4251	negative regulation of phosphorylation
EFI48_RS20560	COG5001	Diguanylate cyclase
EFI48_RS20570	COG2217	Heavy metal translocating P-type atpase
EFI48_RS20575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EFI48_RS20580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EFI48_RS20585	COG1561	YicC-like family, N-terminal region
EFI48_RS20615	COG1715	Restriction endonuclease
EFI48_RS20625	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EFI48_RS20630	COG0732	type I restriction modification DNA specificity domain
EFI48_RS20635	COG5433	transposase activity
EFI48_RS20670	COG0583	DNA-binding transcription factor activity
EFI48_RS20690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EFI48_RS20695	COG0385	Bile acid
EFI48_RS20700	COG0531	amino acid
EFI48_RS20705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EFI48_RS20710	COG0531	amino acid
EFI48_RS20715	COG2731	YhcH YjgK YiaL family protein
EFI48_RS20720	COG3250	beta-galactosidase activity
EFI48_RS20725	COG1609	Transcriptional regulator
EFI48_RS20760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EFI48_RS20765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EFI48_RS20765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EFI48_RS20775	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EFI48_RS20780	COG3074	FtsZ-dependent cytokinesis
EFI48_RS20790	COG1045	serine acetyltransferase
EFI48_RS20800	COG0745	RESPONSE REGULATOR receiver
EFI48_RS20805	COG2205	protein histidine kinase activity
EFI48_RS20810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EFI48_RS20815	COG0534	Mate efflux family protein
EFI48_RS20830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EFI48_RS20835	COG2937	Belongs to the GPAT DAPAT family
EFI48_RS20840	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EFI48_RS20845	COG3161	chorismate lyase activity
EFI48_RS20870	COG0604	alcohol dehydrogenase
EFI48_RS20875	COG1609	Transcriptional regulator
EFI48_RS20880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EFI48_RS20895	COG1519	Transferase
EFI48_RS20900	COG0859	PFAM glycosyl transferase family 9
EFI48_RS20905	COG0463	Glycosyl transferase, family 2
EFI48_RS20910	COG0859	PFAM glycosyl transferase family 9
EFI48_RS20915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EFI48_RS20920	COG2990	Protein conserved in bacteria
EFI48_RS20925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EFI48_RS20935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EFI48_RS20940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EFI48_RS20945	COG2003	Belongs to the UPF0758 family
EFI48_RS20950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EFI48_RS20955	COG0756	dUTP diphosphatase activity
EFI48_RS20960	COG1309	transcriptional regulator
EFI48_RS20965	COG0668	transmembrane transport
EFI48_RS20970	COG0166	Belongs to the GPI family
EFI48_RS20975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EFI48_RS20995	COG1042	CoA-binding domain protein
EFI48_RS20995	COG0045	succinate-CoA ligase (ADP-forming) activity
EFI48_RS20995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EFI48_RS21035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EFI48_RS21045	COG0583	DNA-binding transcription factor activity
EFI48_RS21060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EFI48_RS21065	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EFI48_RS21070	COG2223	nitrite transmembrane transporter activity
EFI48_RS21075	COG3279	Response regulator of the LytR AlgR family
EFI48_RS21080	COG3275	phosphorelay sensor kinase activity
EFI48_RS21085	COG2081	HI0933 family
EFI48_RS21090	COG1528	Iron-storage protein
EFI48_RS21095	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EFI48_RS21105	COG0589	response to stress
EFI48_RS21145	COG3642	lipopolysaccharide core region biosynthetic process
EFI48_RS21150	COG0859	PFAM glycosyl transferase family 9
EFI48_RS21160	COG0194	GDP metabolic process
EFI48_RS21165	COG1758	RNA polymerase activity
EFI48_RS21170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EFI48_RS21175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EFI48_RS21185	COG2267	carboxylic ester hydrolase activity
EFI48_RS21190	COG0561	phosphatase activity
EFI48_RS21220	COG1309	transcriptional regulator
EFI48_RS21225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EFI48_RS21230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EFI48_RS21235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFI48_RS21235	COG4191	Histidine kinase
EFI48_RS21240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EFI48_RS21265	COG2205	protein histidine kinase activity
EFI48_RS21270	COG0745	RESPONSE REGULATOR receiver
EFI48_RS21275	COG2814	Major facilitator Superfamily
EFI48_RS21290	COG3977	Valine--pyruvate aminotransferase
EFI48_RS21295	COG0071	Belongs to the small heat shock protein (HSP20) family
EFI48_RS21300	COG0071	Belongs to the small heat shock protein (HSP20) family
EFI48_RS21305	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EFI48_RS21315	COG2378	regulation of single-species biofilm formation
EFI48_RS21330	COG0187	DNA topoisomerase II activity
EFI48_RS21340	COG0592	DNA-directed DNA polymerase activity
EFI48_RS21345	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EFI48_RS21360	COG1126	abc transporter atp-binding protein
EFI48_RS21365	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EFI48_RS21370	COG0594	ribonuclease P activity
EFI48_RS21375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EFI48_RS21380	COG0706	membrane insertase activity
EFI48_RS21385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EFI48_RS21390	COG4974	Belongs to the 'phage' integrase family
EFI48_RS21570	COG3550	peptidyl-serine autophosphorylation
EFI48_RS21575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EFI48_RS21580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EFI48_RS21585	COG1120	ATPase activity
EFI48_RS21590	COG4615	Cyclic peptide transporter
EFI48_RS21595	COG4774	siderophore transport
EFI48_RS21600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EFI48_RS21605	COG0445	tRNA wobble uridine modification
EFI48_RS21610	COG0357	Ribosomal RNA small subunit methyltransferase G
EFI48_RS21615	COG1192	Involved in chromosome partitioning
EFI48_RS21620	COG1475	DNA binding
EFI48_RS21630	COG0356	it plays a direct role in the translocation of protons across the membrane
EFI48_RS21640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EFI48_RS21645	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation