locus-tag	class	description
H7R57_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7R57_RS00010	COG0592	DNA-directed DNA polymerase activity
H7R57_RS00035	COG2378	regulation of single-species biofilm formation
H7R57_RS00045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7R57_RS00050	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R57_RS00060	COG1484	DNA-dependent DNA replication
H7R57_RS00065	COG4584	PFAM Integrase catalytic
H7R57_RS00070	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R57_RS00075	COG3977	Valine--pyruvate aminotransferase
H7R57_RS00085	COG2814	Major facilitator Superfamily
H7R57_RS00090	COG0745	RESPONSE REGULATOR receiver
H7R57_RS00095	COG2205	protein histidine kinase activity
H7R57_RS00115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R57_RS00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R57_RS00120	COG4191	Histidine kinase
H7R57_RS00125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R57_RS00130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R57_RS00135	COG1309	transcriptional regulator
H7R57_RS00165	COG1484	DNA-dependent DNA replication
H7R57_RS00170	COG4584	PFAM Integrase catalytic
H7R57_RS00185	COG0561	phosphatase activity
H7R57_RS00190	COG2267	carboxylic ester hydrolase activity
H7R57_RS00200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R57_RS00205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R57_RS00210	COG1758	RNA polymerase activity
H7R57_RS00220	COG0859	PFAM glycosyl transferase family 9
H7R57_RS00225	COG3642	lipopolysaccharide core region biosynthetic process
H7R57_RS00265	COG0589	response to stress
H7R57_RS00275	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7R57_RS00280	COG1528	Iron-storage protein
H7R57_RS00285	COG2081	HI0933 family
H7R57_RS00290	COG3275	phosphorelay sensor kinase activity
H7R57_RS00295	COG3279	Response regulator of the LytR AlgR family
H7R57_RS00300	COG2223	nitrite transmembrane transporter activity
H7R57_RS00305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7R57_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7R57_RS00325	COG0583	DNA-binding transcription factor activity
H7R57_RS00335	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H7R57_RS00365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7R57_RS00370	COG2166	iron-sulfur cluster assembly
H7R57_RS00375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7R57_RS00390	COG3245	cytochrome
H7R57_RS00395	COG1063	alcohol dehydrogenase
H7R57_RS00400	COG0156	8-amino-7-oxononanoate synthase activity
H7R57_RS00410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R57_RS00430	COG0438	transferase activity, transferring glycosyl groups
H7R57_RS00435	COG3306	glycosyltransferase involved in LPS biosynthesis
H7R57_RS00470	COG1280	lysine exporter protein (LysE YggA)
H7R57_RS00515	COG0210	DNA helicase
H7R57_RS00520	COG1744	ABC transporter substrate-binding protein PnrA-like
H7R57_RS00525	COG3845	ABC transporter
H7R57_RS00530	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7R57_RS00535	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7R57_RS00540	COG2239	Acts as a magnesium transporter
H7R57_RS00545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R57_RS00545	COG1648	precorrin-2 dehydrogenase activity
H7R57_RS00550	COG2116	formate transmembrane transporter activity
H7R57_RS00560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R57_RS00565	COG0842	Transport permease protein
H7R57_RS00570	COG0842	Transport permease protein
H7R57_RS00575	COG1131	(ABC) transporter
H7R57_RS00580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R57_RS00595	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7R57_RS00600	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7R57_RS00610	COG0018	arginyl-trna synthetase
H7R57_RS00620	COG1595	DNA-templated transcription, initiation
H7R57_RS00630	COG1968	undecaprenyl-diphosphatase activity
H7R57_RS00635	COG2017	converts alpha-aldose to the beta-anomer
H7R57_RS00640	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7R57_RS00645	COG1085	galactose-1-phosphate uridylyltransferase
H7R57_RS00650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R57_RS00655	COG1609	Transcriptional regulator
H7R57_RS00660	COG3250	beta-galactosidase activity
H7R57_RS00685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R57_RS00700	COG0366	Alpha amylase catalytic
H7R57_RS00715	COG0443	Heat shock 70 kDa protein
H7R57_RS00720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R57_RS00725	COG3045	CreA protein
H7R57_RS00745	COG0174	glutamine synthetase
H7R57_RS00765	COG3842	ATPase activity
H7R57_RS00770	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R57_RS00775	COG1177	transmembrane transport
H7R57_RS00780	COG2258	MOSC domain
H7R57_RS00795	COG2050	protein possibly involved in aromatic compounds catabolism
H7R57_RS00800	COG0514	ATP-dependent DNA helicase (RecQ)
H7R57_RS00810	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7R57_RS00820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7R57_RS00835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R57_RS00850	COG0254	rRNA binding
H7R57_RS00855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7R57_RS00865	COG0702	epimerase
H7R57_RS00870	COG0814	amino acid
H7R57_RS00875	COG0281	malic enzyme
H7R57_RS00880	COG1295	ribonuclease BN
H7R57_RS00885	COG1490	D-aminoacyl-tRNA deacylase activity
H7R57_RS00890	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7R57_RS00895	COG0456	acetyltransferase
H7R57_RS00905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7R57_RS00910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R57_RS00915	COG2610	gluconate transmembrane transporter activity
H7R57_RS00920	COG3265	gluconokinase activity
H7R57_RS00930	COG0800	Aldolase
H7R57_RS00935	COG2207	Transcriptional regulator
H7R57_RS00945	COG1609	Transcriptional regulator
H7R57_RS00955	COG4942	peptidase
H7R57_RS00960	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7R57_RS00965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R57_RS00970	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7R57_RS00975	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7R57_RS00980	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7R57_RS00980	COG0316	Belongs to the HesB IscA family
H7R57_RS00985	COG1040	competence protein
H7R57_RS00990	COG0596	Alpha beta hydrolase
H7R57_RS01010	COG2183	response to ionizing radiation
H7R57_RS01035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R57_RS01050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7R57_RS01055	COG1484	DNA-dependent DNA replication
H7R57_RS01060	COG4584	PFAM Integrase catalytic
H7R57_RS01115	COG0051	transcription antitermination factor activity, RNA binding
H7R57_RS01120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7R57_RS01125	COG0088	Forms part of the polypeptide exit tunnel
H7R57_RS01130	COG0089	rRNA binding
H7R57_RS01135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7R57_RS01140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7R57_RS01145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7R57_RS01150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7R57_RS01155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7R57_RS01160	COG0255	Belongs to the universal ribosomal protein uL29 family
H7R57_RS01165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7R57_RS01170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7R57_RS01175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7R57_RS01180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7R57_RS01185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7R57_RS01190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7R57_RS01195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7R57_RS01200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7R57_RS01205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7R57_RS01210	COG1841	ribosomal large subunit assembly
H7R57_RS01215	COG0200	Binds to the 23S rRNA
H7R57_RS01220	COG0201	protein transport
H7R57_RS01225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7R57_RS01230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7R57_RS01235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7R57_RS01240	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7R57_RS01245	COG0202	RNA polymerase activity
H7R57_RS01250	COG0203	ribosomal protein L17
H7R57_RS01285	COG4584	PFAM Integrase catalytic
H7R57_RS01290	COG1484	DNA-dependent DNA replication
H7R57_RS01300	COG3706	GGDEF domain
H7R57_RS01325	COG0583	DNA-binding transcription factor activity
H7R57_RS01335	COG1741	Belongs to the pirin family
H7R57_RS01340	COG2259	Doxx family
H7R57_RS01345	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7R57_RS01350	COG1074	ATP-dependent DNA helicase activity
H7R57_RS01355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R57_RS01370	COG2199	diguanylate cyclase activity
H7R57_RS01370	COG2203	Gaf domain
H7R57_RS01385	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R57_RS01410	COG1175	transmembrane transport
H7R57_RS01420	COG3842	ATPase activity
H7R57_RS01450	COG2873	o-acetylhomoserine
H7R57_RS01475	COG5380	lipid catabolic process
H7R57_RS01480	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7R57_RS01485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R57_RS01510	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H7R57_RS01510	COG0456	acetyltransferase
H7R57_RS01515	COG0454	-acetyltransferase
H7R57_RS01515	COG0456	acetyltransferase
H7R57_RS01540	COG2927	DNA polymerase III (CHI subunit)
H7R57_RS01545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R57_RS01550	COG0795	lipopolysaccharide-transporting ATPase activity
H7R57_RS01555	COG0795	lipopolysaccharide-transporting ATPase activity
H7R57_RS01705	COG4695	Portal protein
H7R57_RS01820	COG4974	Belongs to the 'phage' integrase family
H7R57_RS01825	COG0582	viral genome integration into host DNA
H7R57_RS01885	COG5002	protein histidine kinase activity
H7R57_RS01885	COG2176	DNA-directed DNA polymerase activity
H7R57_RS01905	COG1484	DNA-dependent DNA replication
H7R57_RS01910	COG4584	PFAM Integrase catalytic
H7R57_RS01925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7R57_RS01930	COG1288	antiporter activity
H7R57_RS01940	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R57_RS01945	COG0564	pseudouridine synthase activity
H7R57_RS01955	COG0542	response to heat
H7R57_RS01960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7R57_RS01965	COG2502	aspartate--ammonia ligase
H7R57_RS01970	COG1522	sequence-specific DNA binding
H7R57_RS01980	COG5413	integral membrane protein
H7R57_RS02000	COG2205	protein histidine kinase activity
H7R57_RS02010	COG2204	response regulator
H7R57_RS02025	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H7R57_RS02055	COG0243	molybdopterin cofactor binding
H7R57_RS02060	COG3005	denitrification pathway
H7R57_RS02065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R57_RS02065	COG4191	Histidine kinase
H7R57_RS02075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7R57_RS02080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R57_RS02085	COG0569	domain protein
H7R57_RS02090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7R57_RS02115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R57_RS02130	COG0250	Participates in transcription elongation, termination and antitermination
H7R57_RS02135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7R57_RS02140	COG0081	regulation of translation
H7R57_RS02145	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7R57_RS02150	COG0222	ribosome binding
H7R57_RS02155	COG0085	RNA polymerase activity
H7R57_RS02160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7R57_RS02165	COG2964	Protein conserved in bacteria
H7R57_RS02175	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R57_RS02180	COG2923	Belongs to the DsrF TusC family
H7R57_RS02185	COG2168	tRNA wobble position uridine thiolation
H7R57_RS02190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7R57_RS02195	COG0049	tRNA binding
H7R57_RS02200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7R57_RS02205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R57_RS02210	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R57_RS02260	COG3714	YhhN family
H7R57_RS02285	COG1301	dicarboxylic acid transport
H7R57_RS02295	COG2095	MarC family integral membrane protein
H7R57_RS02305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R57_RS02315	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R57_RS02325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R57_RS02340	COG1770	oligopeptidase
H7R57_RS02355	COG4221	oxidoreductase activity
H7R57_RS02360	COG0583	DNA-binding transcription factor activity
H7R57_RS02365	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R57_RS02390	COG0742	ribosomal rna small subunit methyltransferase
H7R57_RS02395	COG0552	protein localization to endoplasmic reticulum
H7R57_RS02400	COG2884	Cell division ATP-binding protein ftsE
H7R57_RS02405	COG2177	Part of the ABC transporter FtsEX involved in
H7R57_RS02415	COG0288	reversible hydration of carbon dioxide
H7R57_RS02420	COG2188	Transcriptional regulator
H7R57_RS02425	COG1228	amidohydrolase
H7R57_RS02430	COG0010	Belongs to the arginase family
H7R57_RS02435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7R57_RS02440	COG2986	histidine ammonia-lyase
H7R57_RS02445	COG0387	Pfam Sodium calcium exchanger
H7R57_RS02455	COG2200	EAL domain
H7R57_RS02460	COG2199	diguanylate cyclase activity
H7R57_RS02460	COG2200	EAL domain
H7R57_RS02505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R57_RS02510	COG1459	type II secretion system
H7R57_RS02525	COG4969	Belongs to the N-Me-Phe pilin family
H7R57_RS02530	COG4968	Prepilin-type N-terminal cleavage methylation domain
H7R57_RS02555	COG1077	Cell shape determining protein MreB Mrl
H7R57_RS02560	COG1792	Involved in formation and maintenance of cell shape
H7R57_RS02565	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7R57_RS02570	COG0424	maF-like protein
H7R57_RS02575	COG1530	ribonuclease E activity
H7R57_RS02580	COG3164	Protein of unknown function
H7R57_RS02590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R57_RS02595	COG0312	modulator of DNA gyrase
H7R57_RS02605	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H7R57_RS02610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H7R57_RS02615	COG1263	PTS System
H7R57_RS02615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R57_RS02620	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H7R57_RS02640	COG0477	Major facilitator Superfamily
H7R57_RS02680	COG0646	methionine synthase
H7R57_RS02680	COG1410	methionine synthase
H7R57_RS02685	COG0189	ligase activity
H7R57_RS02690	COG0642	Histidine kinase
H7R57_RS02695	COG0745	RESPONSE REGULATOR receiver
H7R57_RS02715	COG0789	Transcriptional regulator
H7R57_RS02720	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7R57_RS02725	COG0352	thiamine-phosphate diphosphorylase activity
H7R57_RS02730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R57_RS02740	COG2022	thiamine diphosphate biosynthetic process
H7R57_RS02745	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R57_RS02770	COG0110	maltose O-acetyltransferase activity
H7R57_RS02785	COG0814	amino acid
H7R57_RS02790	COG3932	Exopolysaccharide synthesis, ExoD
H7R57_RS02805	COG0004	ammonium transporteR
H7R57_RS02810	COG3133	Outer membrane lipoprotein
H7R57_RS02815	COG0456	acetyltransferase
H7R57_RS02840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7R57_RS02845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7R57_RS02860	COG0494	nUDIX hydrolase
H7R57_RS02865	COG0628	permease
H7R57_RS02890	COG3284	Transcriptional regulator
H7R57_RS02900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R57_RS02900	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H7R57_RS02900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7R57_RS02905	COG1461	Dihydroxyacetone kinase
H7R57_RS02910	COG2376	Dihydroxyacetone kinase
H7R57_RS02920	COG2252	PERMEase
H7R57_RS02955	COG1396	sequence-specific DNA binding
H7R57_RS02990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R57_RS03035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7R57_RS03050	COG3047	cAMP biosynthetic process
H7R57_RS03055	COG0840	transmembrane signaling receptor activity
H7R57_RS03080	COG3135	benzoate transporter
H7R57_RS03085	COG1396	sequence-specific DNA binding
H7R57_RS03130	COG4584	PFAM Integrase catalytic
H7R57_RS03135	COG1484	DNA-dependent DNA replication
H7R57_RS03145	COG4584	PFAM Integrase catalytic
H7R57_RS03150	COG1484	DNA-dependent DNA replication
H7R57_RS03160	COG1042	CoA-binding domain protein
H7R57_RS03160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R57_RS03160	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R57_RS03195	COG2194	sulfuric ester hydrolase activity
H7R57_RS03205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7R57_RS03210	COG5642	Protein of unknown function (DUF2384)
H7R57_RS03230	COG0789	Transcriptional regulator
H7R57_RS03245	COG0672	)-iron permease
H7R57_RS03250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R57_RS03340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R57_RS03380	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7R57_RS03385	COG0038	chloride channel
H7R57_RS03395	COG0316	Belongs to the HesB IscA family
H7R57_RS03405	COG1757	Na H antiporter
H7R57_RS03420	COG1484	DNA-dependent DNA replication
H7R57_RS03425	COG4584	PFAM Integrase catalytic
H7R57_RS03460	COG0297	glycogen (starch) synthase activity
H7R57_RS03465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7R57_RS03470	COG2813	Specifically methylates the guanine in position
H7R57_RS03475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R57_RS03480	COG3025	triphosphatase activity
H7R57_RS03485	COG1392	Phosphate transport regulator
H7R57_RS03490	COG0306	phosphate transporter
H7R57_RS03495	COG0527	aspartate kinase activity
H7R57_RS03495	COG0460	homoserine dehydrogenase
H7R57_RS03500	COG0626	cystathionine gamma-synthase activity
H7R57_RS03515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R57_RS03520	COG0814	amino acid
H7R57_RS03525	COG1218	3'(2'),5'-bisphosphate nucleotidase
H7R57_RS03530	COG0494	nUDIX hydrolase
H7R57_RS03535	COG1011	Hydrolase
H7R57_RS03550	COG0110	maltose O-acetyltransferase activity
H7R57_RS03555	COG3174	membrane
H7R57_RS03560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7R57_RS03570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7R57_RS03575	COG4208	sulfate ABC transporter
H7R57_RS03580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7R57_RS03585	COG0583	DNA-binding transcription factor activity
H7R57_RS03590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7R57_RS03595	COG0765	amino acid transport
H7R57_RS03605	COG1126	abc transporter atp-binding protein
H7R57_RS03610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R57_RS03615	COG3397	chitin binding
H7R57_RS03620	COG0840	transmembrane signaling receptor activity
H7R57_RS03635	COG0633	Ferredoxin
H7R57_RS03635	COG0543	2 iron, 2 sulfur cluster binding
H7R57_RS03650	COG1328	CTP reductase activity
H7R57_RS03655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R57_RS03670	COG1448	Aminotransferase
H7R57_RS03710	COG0513	Belongs to the DEAD box helicase family
H7R57_RS03740	COG3112	Uncharacterised protein family (UPF0231)
H7R57_RS03745	COG3835	regulator
H7R57_RS03750	COG2610	gluconate transmembrane transporter activity
H7R57_RS03755	COG1929	Belongs to the glycerate kinase type-1 family
H7R57_RS03770	COG0583	DNA-binding transcription factor activity
H7R57_RS03775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R57_RS03785	COG1872	DUF167
H7R57_RS03790	COG0762	integral membrane protein
H7R57_RS03795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7R57_RS03800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7R57_RS03825	COG3022	response to hydroperoxide
H7R57_RS03845	COG0347	Belongs to the P(II) protein family
H7R57_RS03850	COG1840	ABC-type Fe3 transport system, periplasmic component
H7R57_RS03860	COG3842	ATPase activity
H7R57_RS03865	COG2837	iron assimilation
H7R57_RS03870	COG1438	arginine binding
H7R57_RS03875	COG1126	abc transporter atp-binding protein
H7R57_RS03880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R57_RS03885	COG4215	(ABC) transporter
H7R57_RS03890	COG4160	amino acid transport
H7R57_RS03895	COG0039	L-malate dehydrogenase activity
H7R57_RS03900	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H7R57_RS03905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R57_RS03905	COG1017	nitric oxide dioxygenase activity
H7R57_RS03915	COG4536	flavin adenine dinucleotide binding
H7R57_RS03920	COG4137	Cytochrome C assembly protein
H7R57_RS03925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7R57_RS03930	COG0228	four-way junction DNA binding
H7R57_RS03935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7R57_RS03940	COG0336	Belongs to the RNA methyltransferase TrmD family
H7R57_RS03945	COG0335	large ribosomal subunit rRNA binding
H7R57_RS03960	COG1051	belongs to the nudix hydrolase family
H7R57_RS03965	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
H7R57_RS03970	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7R57_RS03975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7R57_RS03980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R57_RS03990	COG0583	DNA-binding transcription factor activity
H7R57_RS03995	COG0640	Transcriptional regulator
H7R57_RS04000	COG0268	Binds directly to 16S ribosomal RNA
H7R57_RS04005	COG0728	peptidoglycan biosynthetic process
H7R57_RS04010	COG0196	riboflavin kinase activity
H7R57_RS04015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7R57_RS04020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7R57_RS04025	COG1047	Peptidyl-prolyl cis-trans
H7R57_RS04030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7R57_RS04065	COG4584	PFAM Integrase catalytic
H7R57_RS04070	COG1484	DNA-dependent DNA replication
H7R57_RS04105	COG4969	Belongs to the N-Me-Phe pilin family
H7R57_RS04110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R57_RS04110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7R57_RS04125	COG1854	S-ribosylhomocysteine lyase activity
H7R57_RS04135	COG2165	general secretion pathway protein
H7R57_RS04140	COG0084	hydrolase, TatD family'
H7R57_RS04145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R57_RS04155	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7R57_RS04160	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7R57_RS04165	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H7R57_RS04170	COG0813	purine-nucleoside phosphorylase activity
H7R57_RS04180	COG0560	Phosphoserine phosphatase
H7R57_RS04195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H7R57_RS04205	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H7R57_RS04210	COG0776	regulation of translation
H7R57_RS04225	COG1914	H( )-stimulated, divalent metal cation uptake system
H7R57_RS04230	COG0360	Binds together with S18 to 16S ribosomal RNA
H7R57_RS04235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7R57_RS04240	COG0359	binds to the 23S rRNA
H7R57_RS04245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R57_RS04270	COG3321	synthase
H7R57_RS04270	COG0604	alcohol dehydrogenase
H7R57_RS04270	COG4221	oxidoreductase activity
H7R57_RS04270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7R57_RS04275	COG1238	metal cluster binding
H7R57_RS04280	COG0612	Peptidase, M16
H7R57_RS04285	COG2918	glutathione biosynthetic process
H7R57_RS04290	COG1022	Amp-dependent synthetase and ligase
H7R57_RS04295	COG0456	acetyltransferase
H7R57_RS04310	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H7R57_RS04330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7R57_RS04340	COG0477	Major facilitator Superfamily
H7R57_RS04345	COG0583	DNA-binding transcription factor activity
H7R57_RS04355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R57_RS04360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R57_RS04370	COG0673	inositol 2-dehydrogenase activity
H7R57_RS04380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7R57_RS04385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7R57_RS04390	COG3036	rescue of stalled ribosome
H7R57_RS04400	COG0138	bifunctional purine biosynthesis protein purh
H7R57_RS04405	COG0151	Belongs to the GarS family
H7R57_RS04425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7R57_RS04435	COG1610	YqeY-like protein
H7R57_RS04440	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7R57_RS04445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7R57_RS04450	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R57_RS04455	COG1027	Aspartate ammonia-lyase
H7R57_RS04460	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7R57_RS04465	COG0534	Mate efflux family protein
H7R57_RS04470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7R57_RS04475	COG0459	protein refolding
H7R57_RS04515	COG1484	DNA-dependent DNA replication
H7R57_RS04520	COG4584	PFAM Integrase catalytic
H7R57_RS04535	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7R57_RS04540	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H7R57_RS04545	COG1178	ABC-type Fe3 transport system permease component
H7R57_RS04565	COG0066	3-isopropylmalate dehydratase activity
H7R57_RS04570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7R57_RS04575	COG0473	3-isopropylmalate dehydrogenase activity
H7R57_RS04580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7R57_RS04605	COG0028	Belongs to the TPP enzyme family
H7R57_RS04610	COG0440	acetolactate synthase activity
H7R57_RS04655	COG3311	Transcriptional regulator
H7R57_RS04705	COG4584	PFAM Integrase catalytic
H7R57_RS04710	COG1484	DNA-dependent DNA replication
H7R57_RS04720	COG2003	Belongs to the UPF0758 family
H7R57_RS04770	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7R57_RS04775	COG0732	type I restriction modification DNA specificity domain
H7R57_RS04780	COG1401	restriction endodeoxyribonuclease activity
H7R57_RS04780	COG1401	restriction endodeoxyribonuclease activity
H7R57_RS04790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7R57_RS04795	COG4584	PFAM Integrase catalytic
H7R57_RS04800	COG1484	DNA-dependent DNA replication
H7R57_RS04820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7R57_RS04835	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7R57_RS04850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R57_RS04880	COG0745	RESPONSE REGULATOR receiver
H7R57_RS04885	COG3104	oligopeptide transport
H7R57_RS04890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7R57_RS04895	COG1555	photosystem II stabilization
H7R57_RS04900	COG0280	phosphate acetyltransferase
H7R57_RS04900	COG0857	belongs to the CobB CobQ family
H7R57_RS04905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R57_RS04915	COG3013	Belongs to the UPF0304 family
H7R57_RS04920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7R57_RS04925	COG2716	regulation of RNA biosynthetic process
H7R57_RS04930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R57_RS04935	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H7R57_RS04940	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7R57_RS04975	COG2198	Histidine kinase
H7R57_RS04975	COG5002	protein histidine kinase activity
H7R57_RS04975	COG0784	Response regulator, receiver
H7R57_RS05010	COG1464	Belongs to the NlpA lipoprotein family
H7R57_RS05015	COG2011	ABC-type metal ion transport system permease component
H7R57_RS05020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7R57_RS05040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7R57_RS05040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7R57_RS05045	COG0802	atpase or kinase
H7R57_RS05055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7R57_RS05060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7R57_RS05065	COG1923	regulation of RNA biosynthetic process
H7R57_RS05070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7R57_RS05075	COG0330	HflC and HflK could
H7R57_RS05080	COG0330	HflC and HflK could
H7R57_RS05085	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H7R57_RS05090	COG0142	geranyltranstransferase activity
H7R57_RS05095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7R57_RS05100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7R57_RS05105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7R57_RS05110	COG3314	Sporulation integral membrane protein YlbJ
H7R57_RS05115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7R57_RS05125	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7R57_RS05130	COG2967	ApaG domain
H7R57_RS05135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7R57_RS05140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7R57_RS05145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R57_RS05150	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7R57_RS05155	COG3178	'Phosphotransferase
H7R57_RS05160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7R57_RS05165	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R57_RS05170	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R57_RS05175	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H7R57_RS05180	COG1073	alpha beta
H7R57_RS05200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7R57_RS05215	COG4628	conserved protein (DUF2132)
H7R57_RS05220	COG0688	phosphatidylethanolamine metabolic process
H7R57_RS05225	COG1162	GTPase activity
H7R57_RS05230	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7R57_RS05270	COG1278	Cold shock
H7R57_RS05280	COG0840	transmembrane signaling receptor activity
H7R57_RS05285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R57_RS05290	COG2252	PERMEase
H7R57_RS05300	COG0488	(ABC) transporter
H7R57_RS05315	COG0741	lytic transglycosylase activity
H7R57_RS05325	COG3416	Protein conserved in bacteria
H7R57_RS05345	COG4608	Belongs to the ABC transporter superfamily
H7R57_RS05350	COG0444	Belongs to the ABC transporter superfamily
H7R57_RS05355	COG4239	(ABC) transporter, permease
H7R57_RS05360	COG4174	ABC transporter (Permease)
H7R57_RS05370	COG0616	signal peptide processing
H7R57_RS05375	COG1902	pentaerythritol trinitrate reductase activity
H7R57_RS05375	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R57_RS05380	COG0778	Nitroreductase
H7R57_RS05390	COG2264	protein methyltransferase activity
H7R57_RS05395	COG0604	alcohol dehydrogenase
H7R57_RS05400	COG0583	DNA-binding transcription factor activity
H7R57_RS05405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R57_RS05405	COG1263	PTS System
H7R57_RS05405	COG2190	(PTS) system
H7R57_RS05410	COG4145	pantothenate transmembrane transporter activity
H7R57_RS05415	COG3924	membrane
H7R57_RS05420	COG0439	Biotin carboxylase
H7R57_RS05425	COG0511	ligase activity, forming carbon-carbon bonds
H7R57_RS05430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7R57_RS05435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R57_RS05455	COG3381	protein complex oligomerization
H7R57_RS05470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7R57_RS05480	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7R57_RS05485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R57_RS05485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R57_RS05505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R57_RS05510	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7R57_RS05515	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7R57_RS05525	COG4166	transmembrane transport
H7R57_RS05530	COG0601	transmembrane transport
H7R57_RS05540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7R57_RS05545	COG0142	geranyltranstransferase activity
H7R57_RS05550	COG1722	exodeoxyribonuclease VII activity
H7R57_RS05555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R57_RS05560	COG1360	Flagellar Motor Protein
H7R57_RS05560	COG1360	Flagellar Motor Protein
H7R57_RS05575	COG1534	Rna-binding protein
H7R57_RS05580	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7R57_RS05590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7R57_RS05595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7R57_RS05600	COG0149	triose-phosphate isomerase activity
H7R57_RS05605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7R57_RS05620	COG0779	Required for maturation of 30S ribosomal subunits
H7R57_RS05625	COG0195	Participates in both transcription termination and antitermination
H7R57_RS05630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7R57_RS05635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7R57_RS05640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7R57_RS05645	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7R57_RS05650	COG1185	polyribonucleotide nucleotidyltransferase activity
H7R57_RS05655	COG2201	protein-glutamate methylesterase activity
H7R57_RS05660	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H7R57_RS05670	COG0840	transmembrane signaling receptor activity
H7R57_RS05680	COG0835	chemotaxis
H7R57_RS05695	COG4584	PFAM Integrase catalytic
H7R57_RS05700	COG1484	DNA-dependent DNA replication
H7R57_RS05720	COG0643	Histidine kinase
H7R57_RS05720	COG2198	Histidine kinase
H7R57_RS05730	COG0745	RESPONSE REGULATOR receiver
H7R57_RS05735	COG0840	transmembrane signaling receptor activity
H7R57_RS05740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R57_RS05750	COG1280	lysine exporter protein (LysE YggA)
H7R57_RS05755	COG0826	peptidase U32
H7R57_RS05760	COG0737	Belongs to the 5'-nucleotidase family
H7R57_RS05765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7R57_RS05780	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H7R57_RS05805	COG0300	oxidoreductase activity
H7R57_RS05845	COG1605	Chorismate mutase
H7R57_RS05845	COG0077	Prephenate dehydratase
H7R57_RS05875	COG3272	Protein of unknown function (DUF1722)
H7R57_RS05880	COG0789	Transcriptional regulator
H7R57_RS05885	COG0415	Belongs to the DNA photolyase family
H7R57_RS05895	COG0300	oxidoreductase activity
H7R57_RS05910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7R57_RS05940	COG1477	protein flavinylation
H7R57_RS05945	COG2871	sodium ion transport
H7R57_RS05950	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R57_RS05955	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R57_RS05960	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R57_RS05965	COG1805	sodium ion transport
H7R57_RS05970	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R57_RS05975	COG0271	Belongs to the BolA IbaG family
H7R57_RS05980	COG2813	Specifically methylates the guanine in position
H7R57_RS05990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R57_RS06000	COG3248	Nucleoside-binding outer membrane protein
H7R57_RS06005	COG1666	GTP binding
H7R57_RS06010	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7R57_RS06025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7R57_RS06030	COG0840	transmembrane signaling receptor activity
H7R57_RS06035	COG0583	DNA-binding transcription factor activity
H7R57_RS06045	COG2363	Small membrane protein
H7R57_RS06050	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H7R57_RS06060	COG0473	3-isopropylmalate dehydrogenase activity
H7R57_RS06065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R57_RS06070	COG1611	Belongs to the LOG family
H7R57_RS06085	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R57_RS06085	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R57_RS06095	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H7R57_RS06125	COG3098	single-species biofilm formation
H7R57_RS06130	COG0564	pseudouridine synthase activity
H7R57_RS06150	COG1263	PTS System
H7R57_RS06150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R57_RS06160	COG2171	N-acyltransferase activity
H7R57_RS06170	COG0024	Methionine aminopeptidase
H7R57_RS06175	COG0052	Belongs to the universal ribosomal protein uS2 family
H7R57_RS06180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7R57_RS06185	COG0528	UMP kinase activity
H7R57_RS06190	COG0233	cytoplasmic translational termination
H7R57_RS06195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7R57_RS06200	COG0575	Belongs to the CDS family
H7R57_RS06205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7R57_RS06210	COG0750	zinc metalloprotease
H7R57_RS06215	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R57_RS06225	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R57_RS06230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R57_RS06235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R57_RS06240	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R57_RS06245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7R57_RS06255	COG0825	malonyl-CoA metabolic process
H7R57_RS06265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R57_RS06275	COG4584	PFAM Integrase catalytic
H7R57_RS06280	COG1484	DNA-dependent DNA replication
H7R57_RS06295	COG0714	Associated with various cellular activities
H7R57_RS06325	COG3104	oligopeptide transport
H7R57_RS06330	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7R57_RS06335	COG1678	Uncharacterized ACR, COG1678
H7R57_RS06345	COG0189	ligase activity
H7R57_RS06350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7R57_RS06360	COG3091	SprT-like family
H7R57_RS06370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7R57_RS06395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7R57_RS06400	COG0739	heme binding
H7R57_RS06405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R57_RS06440	COG0814	amino acid
H7R57_RS06460	COG0531	amino acid
H7R57_RS06465	COG3710	Transcriptional regulator
H7R57_RS06475	COG0531	amino acid
H7R57_RS06480	COG1982	Orn Lys Arg decarboxylase major
H7R57_RS06485	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7R57_RS06495	COG3590	peptidase
H7R57_RS06505	COG2199	diguanylate cyclase activity
H7R57_RS06505	COG2203	Gaf domain
H7R57_RS06540	COG0366	Alpha amylase catalytic
H7R57_RS06555	COG0463	Glycosyl transferase, family 2
H7R57_RS06570	COG2989	Protein conserved in bacteria
H7R57_RS06575	COG3108	Peptidase M15
H7R57_RS06585	COG2860	membrane
H7R57_RS06595	COG1196	nuclear chromosome segregation
H7R57_RS06600	COG3115	cell septum assembly
H7R57_RS06605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7R57_RS06615	COG1328	CTP reductase activity
H7R57_RS06620	COG0602	queuosine metabolic process
H7R57_RS06665	COG0281	malic enzyme
H7R57_RS06670	COG3290	protein histidine kinase activity
H7R57_RS06680	COG0697	spore germination
H7R57_RS06690	COG3706	GGDEF domain
H7R57_RS06695	COG0346	lactoylglutathione lyase activity
H7R57_RS06700	COG0745	RESPONSE REGULATOR receiver
H7R57_RS06705	COG5002	protein histidine kinase activity
H7R57_RS06730	COG3142	Participates in the control of copper homeostasis
H7R57_RS06735	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R57_RS06750	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H7R57_RS06770	COG0019	diaminopimelate decarboxylase activity
H7R57_RS06775	COG1115	amino acid carrier protein
H7R57_RS06780	COG2233	PERMEase
H7R57_RS06795	COG0534	Mate efflux family protein
H7R57_RS06805	COG0281	malic enzyme
H7R57_RS06840	COG0733	neurotransmitter:sodium symporter activity
H7R57_RS06850	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R57_RS06855	COG3706	GGDEF domain
H7R57_RS06865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R57_RS06870	COG1032	radical SAM domain protein
H7R57_RS06905	COG0673	inositol 2-dehydrogenase activity
H7R57_RS06910	COG2920	part of a sulfur-relay system
H7R57_RS06915	COG1289	transmembrane transporter activity
H7R57_RS06920	COG0670	Belongs to the BI1 family
H7R57_RS06935	COG1486	melibiose metabolic process
H7R57_RS06940	COG1917	Cupin 2, conserved barrel domain protein
H7R57_RS06940	COG2169	Transcriptional regulator
H7R57_RS06945	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7R57_RS06950	COG2723	6-phospho-beta-galactosidase activity
H7R57_RS06955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7R57_RS06960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7R57_RS06970	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H7R57_RS06980	COG3156	type II secretion system protein K
H7R57_RS06985	COG4795	General secretion pathway protein
H7R57_RS06990	COG2165	general secretion pathway protein
H7R57_RS07000	COG2165	general secretion pathway protein
H7R57_RS07005	COG1459	type II secretion system
H7R57_RS07010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R57_RS07015	COG1450	Type ii and iii secretion system protein
H7R57_RS07030	COG3409	Peptidoglycan-binding domain 1 protein
H7R57_RS07030	COG3267	Type II secretory pathway component ExeA
H7R57_RS07035	COG2770	Histidine kinase
H7R57_RS07035	COG3437	response regulator, receiver
H7R57_RS07050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7R57_RS07055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7R57_RS07060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R57_RS07070	COG2190	(PTS) system
H7R57_RS07075	COG3706	GGDEF domain
H7R57_RS07080	COG3264	Mechanosensitive ion channel
H7R57_RS07080	COG1196	nuclear chromosome segregation
H7R57_RS07085	COG0469	pyruvate kinase activity
H7R57_RS07095	COG3384	dioxygenase
H7R57_RS07100	COG0419	ATPase involved in DNA repair
H7R57_RS07105	COG0420	3'-5' exonuclease activity
H7R57_RS07115	COG2974	May be involved in recombination
H7R57_RS07125	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7R57_RS07135	COG0531	amino acid
H7R57_RS07145	COG0531	amino acid
H7R57_RS07160	COG1917	Cupin 2, conserved barrel domain protein
H7R57_RS07160	COG1396	sequence-specific DNA binding
H7R57_RS07165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R57_RS07195	COG3152	Membrane
H7R57_RS07200	COG3161	chorismate lyase activity
H7R57_RS07225	COG1720	tRNA m6t6A37 methyltransferase activity
H7R57_RS07245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7R57_RS07250	COG4988	ABC transporter
H7R57_RS07265	COG0745	RESPONSE REGULATOR receiver
H7R57_RS07275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R57_RS07290	COG0640	Transcriptional regulator
H7R57_RS07305	COG0798	PFAM Bile acid sodium symporter
H7R57_RS07315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R57_RS07320	COG3550	peptidyl-serine autophosphorylation
H7R57_RS07325	COG1396	sequence-specific DNA binding
H7R57_RS07330	COG1988	membrane-bound metal-dependent
H7R57_RS07345	COG0159	tryptophan synthase activity
H7R57_RS07350	COG0133	tryptophan synthase activity
H7R57_RS07355	COG0135	phosphoribosylanthranilate isomerase activity
H7R57_RS07355	COG0134	indole-3-glycerol-phosphate synthase activity
H7R57_RS07360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R57_RS07365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R57_RS07365	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R57_RS07370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7R57_RS07380	COG0009	L-threonylcarbamoyladenylate synthase
H7R57_RS07390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7R57_RS07400	COG1993	acr, cog1993
H7R57_RS07405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7R57_RS07415	COG1946	Acyl-CoA thioesterase
H7R57_RS07420	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H7R57_RS07425	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7R57_RS07435	COG0083	homoserine kinase activity
H7R57_RS07440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7R57_RS07450	COG1484	DNA-dependent DNA replication
H7R57_RS07455	COG4584	PFAM Integrase catalytic
H7R57_RS07460	COG1943	Transposase
H7R57_RS07470	COG4584	PFAM Integrase catalytic
H7R57_RS07475	COG1484	DNA-dependent DNA replication
H7R57_RS07480	COG0675	Transposase, IS605 OrfB family
H7R57_RS07495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R57_RS07515	COG1342	Belongs to the UPF0251 family
H7R57_RS07530	COG1309	transcriptional regulator
H7R57_RS07535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R57_RS07540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R57_RS07550	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7R57_RS07590	COG0367	asparagine synthase
H7R57_RS07600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H7R57_RS07620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7R57_RS07635	COG1091	dTDP-4-dehydrorhamnose reductase activity
H7R57_RS07650	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H7R57_RS07660	COG1484	DNA-dependent DNA replication
H7R57_RS07665	COG4584	PFAM Integrase catalytic
H7R57_RS07685	COG1136	(ABC) transporter
H7R57_RS07685	COG0577	efflux transmembrane transporter activity
H7R57_RS07690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R57_RS07695	COG1227	inorganic diphosphatase activity
H7R57_RS07700	COG0497	DNA recombination
H7R57_RS07705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7R57_RS07710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7R57_RS07715	COG0443	Heat shock 70 kDa protein
H7R57_RS07720	COG0484	heat shock protein binding
H7R57_RS07750	COG1285	pathogenesis
H7R57_RS07760	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R57_RS07795	COG5001	Diguanylate cyclase
H7R57_RS07800	COG0095	Lipoate-protein ligase
H7R57_RS07810	COG0702	epimerase
H7R57_RS07815	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R57_RS07825	COG1484	DNA-dependent DNA replication
H7R57_RS07840	COG0564	pseudouridine synthase activity
H7R57_RS07845	COG1957	nucleoside hydrolase
H7R57_RS07875	COG1280	lysine exporter protein (LysE YggA)
H7R57_RS07890	COG3263	regulation of cellular component size
H7R57_RS07900	COG1876	peptidase activity
H7R57_RS07905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7R57_RS07910	COG1393	Belongs to the ArsC family
H7R57_RS07920	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R57_RS07925	COG1473	amidohydrolase
H7R57_RS07935	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R57_RS07945	COG0017	Asparaginyl-tRNA synthetase
H7R57_RS07960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7R57_RS07965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R57_RS07970	COG0156	8-amino-7-oxononanoate synthase activity
H7R57_RS07975	COG1073	alpha beta
H7R57_RS07975	COG2226	methyltransferase
H7R57_RS07980	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7R57_RS07985	COG0501	Belongs to the peptidase M48B family
H7R57_RS07990	COG0633	Ferredoxin
H7R57_RS07990	COG0633	Ferredoxin
H7R57_RS07990	COG3217	Mosc domain protein beta barrel domain protein
H7R57_RS07990	COG3217	Mosc domain protein beta barrel domain protein
H7R57_RS08000	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7R57_RS08000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7R57_RS08000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7R57_RS08000	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7R57_RS08010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R57_RS08015	COG1607	acyl-coa hydrolase
H7R57_RS08025	COG3021	interspecies interaction between organisms
H7R57_RS08030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7R57_RS08035	COG2027	D-alanyl-D-alanine carboxypeptidase
H7R57_RS08040	COG1061	Type III restriction enzyme res subunit
H7R57_RS08045	COG1566	PFAM secretion protein HlyD family protein
H7R57_RS08055	COG1966	Carbon starvation protein
H7R57_RS08060	COG3279	Response regulator of the LytR AlgR family
H7R57_RS08065	COG3275	phosphorelay sensor kinase activity
H7R57_RS08080	COG1940	carbohydrate kinase activity
H7R57_RS08080	COG1846	Transcriptional regulator
H7R57_RS08085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R57_RS08090	COG0363	glucosamine-6-phosphate deaminase activity
H7R57_RS08095	COG1263	PTS System
H7R57_RS08095	COG2190	(PTS) system
H7R57_RS08095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R57_RS08115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R57_RS08120	COG0735	belongs to the Fur family
H7R57_RS08130	COG0716	FMN binding
H7R57_RS08145	COG0596	Alpha beta hydrolase
H7R57_RS08150	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H7R57_RS08155	COG0033	Phosphoglucomutase
H7R57_RS08160	COG2951	lytic endotransglycosylase activity
H7R57_RS08165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7R57_RS08170	COG4136	ATPase activity
H7R57_RS08175	COG4135	transport system, permease component
H7R57_RS08180	COG4134	Bacterial extracellular solute-binding protein
H7R57_RS08185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R57_RS08190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7R57_RS08200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R57_RS08210	COG0729	surface antigen
H7R57_RS08215	COG2911	Protein conserved in bacteria
H7R57_RS08235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7R57_RS08245	COG0741	lytic transglycosylase activity
H7R57_RS08255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R57_RS08260	COG4771	TonB-dependent receptor
H7R57_RS08265	COG1169	isochorismate synthase
H7R57_RS08270	COG1021	2,3-dihydroxybenzoate-AMP ligase
H7R57_RS08275	COG1535	isochorismatase
H7R57_RS08275	COG3433	isochorismatase activity
H7R57_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
H7R57_RS08285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7R57_RS08285	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H7R57_RS08310	COG1278	Cold shock
H7R57_RS08335	COG0747	negative chemotaxis
H7R57_RS08340	COG0697	spore germination
H7R57_RS08345	COG1349	DNA-binding transcription factor activity
H7R57_RS08350	COG1882	Formate acetyltransferase
H7R57_RS08355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R57_RS08360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R57_RS08385	COG4166	transmembrane transport
H7R57_RS08390	COG0622	Phosphoesterase
H7R57_RS08405	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H7R57_RS08410	COG0835	chemotaxis
H7R57_RS08410	COG0784	Response regulator, receiver
H7R57_RS08415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7R57_RS08420	COG1815	bacterial-type flagellum-dependent cell motility
H7R57_RS08440	COG4787	bacterial-type flagellum-dependent cell motility
H7R57_RS08450	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7R57_RS08455	COG1706	bacterial-type flagellum-dependent cell motility
H7R57_RS08460	COG3951	Flagellar rod assembly protein muramidase FlgJ
H7R57_RS08460	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7R57_RS08475	COG2239	Acts as a magnesium transporter
H7R57_RS08485	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7R57_RS08490	COG2716	regulation of RNA biosynthetic process
H7R57_RS08515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7R57_RS08520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7R57_RS08525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7R57_RS08530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7R57_RS08550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7R57_RS08570	COG0590	tRNA wobble adenosine to inosine editing
H7R57_RS08575	COG0573	inorganic phosphate transmembrane transporter activity
H7R57_RS08580	COG0581	inorganic phosphate transmembrane transporter activity
H7R57_RS08585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7R57_RS08590	COG0704	Plays a role in the regulation of phosphate uptake
H7R57_RS08595	COG1253	flavin adenine dinucleotide binding
H7R57_RS08615	COG4584	PFAM Integrase catalytic
H7R57_RS08620	COG1484	DNA-dependent DNA replication
H7R57_RS08640	COG1126	abc transporter atp-binding protein
H7R57_RS08645	COG0765	amino acid transport
H7R57_RS08650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R57_RS08655	COG2199	diguanylate cyclase activity
H7R57_RS08670	COG2197	response regulator
H7R57_RS08675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R57_RS08700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7R57_RS08705	COG0477	Major facilitator Superfamily
H7R57_RS08710	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7R57_RS08720	COG1199	ATP-dependent helicase activity
H7R57_RS08730	COG0287	Prephenate dehydrogenase
H7R57_RS08730	COG1605	Chorismate mutase
H7R57_RS08735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R57_RS08745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R57_RS08750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R57_RS08785	COG0537	adenosine 5'-monophosphoramidase activity
H7R57_RS08790	COG0840	transmembrane signaling receptor activity
H7R57_RS08800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7R57_RS08815	COG1301	dicarboxylic acid transport
H7R57_RS08825	COG2354	Protein conserved in bacteria
H7R57_RS08830	COG1164	Oligoendopeptidase f
H7R57_RS08835	COG2233	PERMEase
H7R57_RS08840	COG3150	esterase
H7R57_RS08845	COG1252	NADH dehydrogenase
H7R57_RS08855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R57_RS08865	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R57_RS08875	COG2373	Large extracellular alpha-helical protein
H7R57_RS08880	COG4953	penicillin-binding protein 1C
H7R57_RS08895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R57_RS08895	COG0301	tRNA thio-modification
H7R57_RS08960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7R57_RS08970	COG2089	acid synthase
H7R57_RS08980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7R57_RS08985	COG1083	cytidylyl-transferase
H7R57_RS08995	COG1086	Polysaccharide biosynthesis protein
H7R57_RS09000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R57_RS09010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7R57_RS09025	COG0483	inositol monophosphate 1-phosphatase activity
H7R57_RS09035	COG0625	glutathione transferase activity
H7R57_RS09040	COG2814	Major facilitator Superfamily
H7R57_RS09045	COG0583	DNA-binding transcription factor activity
H7R57_RS09055	COG0243	molybdopterin cofactor binding
H7R57_RS09075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R57_RS09080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R57_RS09085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7R57_RS09090	COG0509	glycine decarboxylation via glycine cleavage system
H7R57_RS09095	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R57_RS09095	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R57_RS09100	COG0840	transmembrane signaling receptor activity
H7R57_RS09105	COG0546	phosphoglycolate phosphatase activity
H7R57_RS09130	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7R57_RS09135	COG0574	Belongs to the PEP-utilizing enzyme family
H7R57_RS09135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7R57_RS09150	COG1464	Belongs to the NlpA lipoprotein family
H7R57_RS09155	COG3083	sulfuric ester hydrolase activity
H7R57_RS09160	COG3082	Protein of unknown function (DUF1414)
H7R57_RS09165	COG3081	Nucleoid-associated protein
H7R57_RS09175	COG1175	transmembrane transport
H7R57_RS09180	COG3833	ABC-type maltose transport systems, permease component
H7R57_RS09185	COG3842	ATPase activity
H7R57_RS09210	COG0425	Belongs to the sulfur carrier protein TusA family
H7R57_RS09215	COG4783	chaperone-mediated protein folding
H7R57_RS09225	COG1393	Belongs to the ArsC family
H7R57_RS09240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R57_RS09245	COG2431	L-lysine efflux transmembrane transporter activity
H7R57_RS09265	COG4160	amino acid transport
H7R57_RS09285	COG0564	pseudouridine synthase activity
H7R57_RS09300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7R57_RS09310	COG0625	glutathione transferase activity
H7R57_RS09315	COG0367	asparagine synthase
H7R57_RS09325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7R57_RS09325	COG4651	solute:proton antiporter activity
H7R57_RS09330	COG0647	UMP catabolic process
H7R57_RS09345	COG1902	pentaerythritol trinitrate reductase activity
H7R57_RS09350	COG1253	flavin adenine dinucleotide binding
H7R57_RS09360	COG0247	lactate metabolic process
H7R57_RS09360	COG0277	FAD linked oxidase domain protein
H7R57_RS09370	COG2050	protein possibly involved in aromatic compounds catabolism
H7R57_RS09385	COG3300	MHYT domain
H7R57_RS09385	COG5001	Diguanylate cyclase
H7R57_RS09390	COG2056	Na+-H+ antiporter family
H7R57_RS09395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R57_RS09400	COG0671	phosphoesterase, PA-phosphatase related
H7R57_RS09405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R57_RS09410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R57_RS09420	COG0101	tRNA pseudouridine synthase activity
H7R57_RS09425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7R57_RS09430	COG0285	dihydrofolate synthase activity
H7R57_RS09435	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H7R57_RS09440	COG0393	Putative heavy-metal-binding
H7R57_RS09450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R57_RS09450	COG1648	precorrin-2 dehydrogenase activity
H7R57_RS09475	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7R57_RS09480	COG1368	sulfuric ester hydrolase activity
H7R57_RS09490	COG0527	aspartate kinase activity
H7R57_RS09495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R57_RS09495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7R57_RS09500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R57_RS09520	COG0596	Alpha beta hydrolase
H7R57_RS09540	COG2814	Major facilitator Superfamily
H7R57_RS09560	COG0672	)-iron permease
H7R57_RS09640	COG4584	PFAM Integrase catalytic
H7R57_RS09645	COG1484	DNA-dependent DNA replication
H7R57_RS09650	COG0393	Putative heavy-metal-binding
H7R57_RS09730	COG3706	GGDEF domain
H7R57_RS09760	COG4584	PFAM Integrase catalytic
H7R57_RS09765	COG1484	DNA-dependent DNA replication
H7R57_RS09770	COG0582	viral genome integration into host DNA
H7R57_RS09790	COG0659	secondary active sulfate transmembrane transporter activity
H7R57_RS09810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7R57_RS09820	COG0392	lysyltransferase activity
H7R57_RS09820	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7R57_RS09830	COG2205	protein histidine kinase activity
H7R57_RS09835	COG0745	RESPONSE REGULATOR receiver
H7R57_RS09910	COG4584	PFAM Integrase catalytic
H7R57_RS09915	COG1484	DNA-dependent DNA replication
H7R57_RS09955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7R57_RS09960	COG1278	Cold shock
H7R57_RS09965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7R57_RS09970	COG0542	response to heat
H7R57_RS09975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7R57_RS09980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7R57_RS09985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7R57_RS09990	COG3134	Outer membrane lipoprotein
H7R57_RS09995	COG3706	GGDEF domain
H7R57_RS10000	COG0492	ferredoxin-NADP+ reductase activity
H7R57_RS10005	COG0686	Belongs to the AlaDH PNT family
H7R57_RS10015	COG1674	ftsk spoiiie
H7R57_RS10015	COG0531	amino acid
H7R57_RS10020	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7R57_RS10025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7R57_RS10030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7R57_RS10035	COG1286	toxin biosynthetic process
H7R57_RS10040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7R57_RS10050	COG0563	adenylate kinase activity
H7R57_RS10055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7R57_RS10065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R57_RS10080	COG5001	Diguanylate cyclase
H7R57_RS10080	COG3300	MHYT domain
H7R57_RS10135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7R57_RS10140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R57_RS10155	COG0513	Belongs to the DEAD box helicase family
H7R57_RS10160	COG0386	Belongs to the glutathione peroxidase family
H7R57_RS10170	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7R57_RS10175	COG0383	alpha-mannosidase activity
H7R57_RS10180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R57_RS10180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R57_RS10180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R57_RS10185	COG2188	Transcriptional regulator
H7R57_RS10190	COG1570	exodeoxyribonuclease VII activity
H7R57_RS10210	COG0517	IMP dehydrogenase activity
H7R57_RS10210	COG0516	GMP reductase activity
H7R57_RS10215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R57_RS10215	COG0519	Catalyzes the synthesis of GMP from XMP
H7R57_RS10260	COG2062	phosphohistidine phosphatase, SixA
H7R57_RS10270	COG0697	spore germination
H7R57_RS10275	COG4166	transmembrane transport
H7R57_RS10280	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7R57_RS10285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7R57_RS10295	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R57_RS10300	COG1136	(ABC) transporter
H7R57_RS10305	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R57_RS10310	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H7R57_RS10320	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7R57_RS10325	COG0740	serine-type endopeptidase activity
H7R57_RS10330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7R57_RS10335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7R57_RS10340	COG0776	regulation of translation
H7R57_RS10345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R57_RS10350	COG0488	(ABC) transporter
H7R57_RS10355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R57_RS10360	COG3162	membrane
H7R57_RS10375	COG1024	Enoyl-CoA hydratase
H7R57_RS10380	COG1115	amino acid carrier protein
H7R57_RS10390	COG3228	Belongs to the MtfA family
H7R57_RS10395	COG1584	GPR1 FUN34 yaaH family protein
H7R57_RS10425	COG1024	Enoyl-CoA hydratase
H7R57_RS10430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7R57_RS10435	COG1960	acyl-CoA dehydrogenase activity
H7R57_RS10440	COG1960	acyl-CoA dehydrogenase activity
H7R57_RS10445	COG1024	Enoyl-CoA hydratase
H7R57_RS10450	COG1024	Enoyl-CoA hydratase
H7R57_RS10460	COG1028	Short-chain dehydrogenase reductase Sdr
H7R57_RS10470	COG0730	response to heat
H7R57_RS10480	COG0582	viral genome integration into host DNA
H7R57_RS10495	COG4584	PFAM Integrase catalytic
H7R57_RS10500	COG1484	DNA-dependent DNA replication
H7R57_RS10515	COG2003	Belongs to the UPF0758 family
H7R57_RS10580	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H7R57_RS10585	COG0437	4 iron, 4 sulfur cluster binding
H7R57_RS10590	COG5557	Pfam Polysulphide reductase, NrfD
H7R57_RS10595	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H7R57_RS10600	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7R57_RS10605	COG1773	rubredoxin
H7R57_RS10620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R57_RS10625	COG0444	Belongs to the ABC transporter superfamily
H7R57_RS10630	COG3842	ATPase activity
H7R57_RS10635	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H7R57_RS10640	COG0375	protein maturation
H7R57_RS10645	COG0309	Hydrogenase expression formation protein (HypE)
H7R57_RS10655	COG0298	carbon dioxide binding
H7R57_RS10660	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7R57_RS10670	COG1921	L-seryl-tRNASec selenium transferase activity
H7R57_RS10680	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7R57_RS10690	COG3260	NADH ubiquinone oxidoreductase 20
H7R57_RS10695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R57_RS10700	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H7R57_RS10700	COG3261	NADH dehydrogenase
H7R57_RS10705	COG0650	Formate hydrogenlyase subunit 4
H7R57_RS10710	COG0651	ATP synthesis coupled electron transport
H7R57_RS10715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R57_RS10720	COG3158	transport of potassium into the cell
H7R57_RS10725	COG1196	nuclear chromosome segregation
H7R57_RS10730	COG5433	transposase activity
H7R57_RS10735	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R57_RS10760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R57_RS10770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R57_RS10775	COG3046	protein related to deoxyribodipyrimidine photolyase
H7R57_RS10785	COG3033	Beta-eliminating lyase
H7R57_RS10790	COG0295	cytidine deaminase activity
H7R57_RS10795	COG1346	cytolysis
H7R57_RS10800	COG1380	Effector of murein hydrolase LrgA
H7R57_RS10805	COG3345	alpha-galactosidase
H7R57_RS10815	COG2925	Exonuclease
H7R57_RS10845	COG1484	DNA-dependent DNA replication
H7R57_RS10850	COG4584	PFAM Integrase catalytic
H7R57_RS10860	COG3088	subunit of a heme lyase
H7R57_RS10860	COG4235	cytochrome complex assembly
H7R57_RS10865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R57_RS10870	COG1138	Cytochrome C-type biogenesis protein
H7R57_RS10875	COG3301	Polysulphide reductase, NrfD
H7R57_RS10880	COG0437	4 iron, 4 sulfur cluster binding
H7R57_RS10885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H7R57_RS10910	COG0247	lactate metabolic process
H7R57_RS10915	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
H7R57_RS10920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7R57_RS10930	COG3012	SEC-C Motif Domain Protein
H7R57_RS10935	COG0840	transmembrane signaling receptor activity
H7R57_RS10940	COG1940	carbohydrate kinase activity
H7R57_RS10940	COG1846	Transcriptional regulator
H7R57_RS10945	COG3148	PFAM DTW domain containing protein
H7R57_RS10950	COG0730	response to heat
H7R57_RS10955	COG0583	DNA-binding transcription factor activity
H7R57_RS10970	COG3593	DNA synthesis involved in DNA repair
H7R57_RS11020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R57_RS11025	COG1011	Hydrolase
H7R57_RS11040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R57_RS11045	COG2832	Protein of unknown function (DUF454)
H7R57_RS11050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7R57_RS11060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7R57_RS11085	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H7R57_RS11090	COG0583	DNA-binding transcription factor activity
H7R57_RS11100	COG1560	Kdo2-lipid A biosynthetic process
H7R57_RS11105	COG1560	Kdo2-lipid A biosynthetic process
H7R57_RS11125	COG0417	DNA replication proofreading
H7R57_RS11140	COG1451	nucleotide metabolic process
H7R57_RS11155	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R57_RS11170	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7R57_RS11170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R57_RS11175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7R57_RS11180	COG2985	domain, Protein
H7R57_RS11180	COG0569	domain protein
H7R57_RS11190	COG0556	nucleotide-excision repair
H7R57_RS11200	COG0586	Pfam SNARE associated Golgi protein
H7R57_RS11205	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7R57_RS11210	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R57_RS11235	COG3829	transcription factor binding
H7R57_RS11265	COG0534	Mate efflux family protein
H7R57_RS11280	COG0307	riboflavin synthase, alpha
H7R57_RS11295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R57_RS11300	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H7R57_RS11305	COG0697	spore germination
H7R57_RS11310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7R57_RS11350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R57_RS11355	COG3099	Belongs to the UPF0263 family
H7R57_RS11360	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7R57_RS11365	COG2894	cell division
H7R57_RS11370	COG0850	regulation of cytokinetic process
H7R57_RS11375	COG3100	YcgL domain-containing protein
H7R57_RS11385	COG2824	Alkylphosphonate utilization operon protein PhnA
H7R57_RS11400	COG3791	Glutathione-dependent formaldehyde-activating
H7R57_RS11405	COG0406	alpha-ribazole phosphatase activity
H7R57_RS11410	COG3706	GGDEF domain
H7R57_RS11415	COG2840	Smr protein MutS2
H7R57_RS11420	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R57_RS11425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7R57_RS11435	COG0513	Belongs to the DEAD box helicase family
H7R57_RS11440	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H7R57_RS11460	COG4584	PFAM Integrase catalytic
H7R57_RS11465	COG1484	DNA-dependent DNA replication
H7R57_RS11475	COG1609	Transcriptional regulator
H7R57_RS11480	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R57_RS11480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R57_RS11485	COG1105	Belongs to the carbohydrate kinase PfkB family
H7R57_RS11490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R57_RS11490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R57_RS11490	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H7R57_RS11495	COG3313	Fe-S protein
H7R57_RS11500	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H7R57_RS11505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R57_RS11510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R57_RS11515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R57_RS11525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R57_RS11535	COG0366	Alpha amylase catalytic
H7R57_RS11555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7R57_RS11560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7R57_RS11565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7R57_RS11570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7R57_RS11575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R57_RS11580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7R57_RS11585	COG0072	phenylalanine-tRNA ligase activity
H7R57_RS11585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R57_RS11590	COG0776	regulation of translation
H7R57_RS11615	COG1609	Transcriptional regulator
H7R57_RS11620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R57_RS11625	COG1879	ABC-type sugar transport system periplasmic component
H7R57_RS11630	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7R57_RS11635	COG1129	ABC transporter
H7R57_RS11640	COG1869	D-ribose catabolic process
H7R57_RS11645	COG0625	glutathione transferase activity
H7R57_RS11675	COG1177	transmembrane transport
H7R57_RS11700	COG0037	tRNA processing
H7R57_RS11705	COG0589	response to stress
H7R57_RS11710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R57_RS11735	COG2010	Cytochrome c
H7R57_RS11750	COG3278	Belongs to the heme-copper respiratory oxidase family
H7R57_RS11760	COG1956	GAF domain-containing protein
H7R57_RS11765	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H7R57_RS11775	COG0308	aminopeptidase N
H7R57_RS11790	COG0167	dihydroorotate dehydrogenase activity
H7R57_RS11805	COG5001	Diguanylate cyclase
H7R57_RS11805	COG4251	negative regulation of phosphorylation
H7R57_RS11805	COG3706	GGDEF domain
H7R57_RS11805	COG2203	Gaf domain
H7R57_RS11810	COG2201	protein-glutamate methylesterase activity
H7R57_RS11845	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R57_RS11885	COG0835	chemotaxis
H7R57_RS11890	COG0840	transmembrane signaling receptor activity
H7R57_RS11920	COG0116	Belongs to the methyltransferase superfamily
H7R57_RS11920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R57_RS11930	COG0488	(ABC) transporter
H7R57_RS11940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R57_RS11945	COG1067	ATP-dependent peptidase activity
H7R57_RS11960	COG1484	DNA-dependent DNA replication
H7R57_RS11965	COG4584	PFAM Integrase catalytic
H7R57_RS11975	COG3141	response to X-ray
H7R57_RS11985	COG4221	oxidoreductase activity
H7R57_RS12010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7R57_RS12030	COG0372	Belongs to the citrate synthase family
H7R57_RS12035	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7R57_RS12045	COG2995	paraquat-inducible protein a
H7R57_RS12050	COG3008	intermembrane lipid transfer
H7R57_RS12075	COG4644	lycopene metabolic process
H7R57_RS12095	COG0084	hydrolase, TatD family'
H7R57_RS12100	COG0470	DNA polymerase III
H7R57_RS12105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7R57_RS12110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7R57_RS12115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7R57_RS12125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7R57_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
H7R57_RS12140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R57_RS12145	COG0416	fatty acid biosynthetic process
H7R57_RS12150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7R57_RS12155	COG1399	metal-binding, possibly nucleic acid-binding protein
H7R57_RS12160	COG0424	maF-like protein
H7R57_RS12180	COG1530	ribonuclease E activity
H7R57_RS12190	COG0306	phosphate transporter
H7R57_RS12195	COG0717	Belongs to the dCTP deaminase family
H7R57_RS12200	COG0572	uridine kinase
H7R57_RS12205	COG0489	protein tyrosine kinase activity
H7R57_RS12210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R57_RS12210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R57_RS12220	COG1254	Belongs to the acylphosphatase family
H7R57_RS12230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R57_RS12240	COG0709	Synthesizes selenophosphate from selenide and ATP
H7R57_RS12245	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H7R57_RS12255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R57_RS12265	COG0318	PFAM AMP-dependent synthetase and ligase
H7R57_RS12270	COG0596	Alpha beta hydrolase
H7R57_RS12280	COG1214	PFAM Peptidase M22, glycoprotease
H7R57_RS12285	COG1199	ATP-dependent helicase activity
H7R57_RS12295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7R57_RS12300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7R57_RS12305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7R57_RS12310	COG0131	Imidazoleglycerol-phosphate dehydratase
H7R57_RS12310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R57_RS12315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7R57_RS12320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7R57_RS12325	COG0107	imidazoleglycerol-phosphate synthase activity
H7R57_RS12330	COG0140	phosphoribosyl-ATP diphosphatase activity
H7R57_RS12330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H7R57_RS12345	COG2199	diguanylate cyclase activity
H7R57_RS12350	COG0318	PFAM AMP-dependent synthetase and ligase
H7R57_RS12360	COG3134	Outer membrane lipoprotein
H7R57_RS12365	COG2080	2 iron, 2 sulfur cluster binding
H7R57_RS12370	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7R57_RS12375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7R57_RS12380	COG2252	PERMEase
H7R57_RS12385	COG0402	S-adenosylhomocysteine deaminase activity
H7R57_RS12395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7R57_RS12395	COG2080	2 iron, 2 sulfur cluster binding
H7R57_RS12400	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7R57_RS12405	COG0402	S-adenosylhomocysteine deaminase activity
H7R57_RS12410	COG0493	'glutamate synthase
H7R57_RS12410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R57_RS12420	COG2068	MobA-Related Protein
H7R57_RS12425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7R57_RS12430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7R57_RS12430	COG3608	succinylglutamate desuccinylase aspartoacylase
H7R57_RS12435	COG0697	spore germination
H7R57_RS12440	COG0549	Belongs to the carbamate kinase family
H7R57_RS12450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7R57_RS12455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7R57_RS12460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7R57_RS12480	COG0242	peptide deformylase activity
H7R57_RS12490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7R57_RS12495	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7R57_RS12500	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H7R57_RS12510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R57_RS12515	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H7R57_RS12525	COG0205	6-phosphofructokinase activity
H7R57_RS12535	COG1301	dicarboxylic acid transport
H7R57_RS12540	COG3123	guanosine phosphorylase activity
H7R57_RS12545	COG1760	l-serine dehydratase
H7R57_RS12550	COG1760	l-serine dehydratase
H7R57_RS12570	COG0814	amino acid
H7R57_RS12585	COG4584	PFAM Integrase catalytic
H7R57_RS12590	COG1484	DNA-dependent DNA replication
H7R57_RS12600	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H7R57_RS12605	COG0514	ATP-dependent DNA helicase (RecQ)
H7R57_RS12610	COG2766	serine protein kinase
H7R57_RS12615	COG2718	Belongs to the UPF0229 family
H7R57_RS12620	COG2719	SpoVR family
H7R57_RS12625	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R57_RS12625	COG1024	Enoyl-CoA hydratase
H7R57_RS12630	COG0183	Belongs to the thiolase family
H7R57_RS12635	COG0714	Associated with various cellular activities
H7R57_RS12670	COG1595	DNA-templated transcription, initiation
H7R57_RS12680	COG2067	long-chain fatty acid transport protein
H7R57_RS12685	COG2067	long-chain fatty acid transport protein
H7R57_RS12690	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7R57_RS12705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7R57_RS12715	COG1643	Atp-dependent helicase
H7R57_RS12720	COG0617	tRNA 3'-terminal CCA addition
H7R57_RS12720	COG0517	IMP dehydrogenase activity
H7R57_RS12720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7R57_RS12740	COG1484	DNA-dependent DNA replication
H7R57_RS12745	COG4584	PFAM Integrase catalytic
H7R57_RS12775	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7R57_RS12795	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7R57_RS12840	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R57_RS12845	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R57_RS12850	COG0567	Dehydrogenase, E1 component
H7R57_RS12860	COG1053	succinate dehydrogenase
H7R57_RS12865	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7R57_RS12870	COG2009	succinate dehydrogenase
H7R57_RS12910	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7R57_RS12925	COG2501	S4 domain
H7R57_RS12935	COG1132	(ABC) transporter
H7R57_RS12940	COG1132	(ABC) transporter
H7R57_RS12945	COG3437	response regulator, receiver
H7R57_RS12945	COG2205	protein histidine kinase activity
H7R57_RS12945	COG4999	Histidine kinase
H7R57_RS12945	COG3850	Histidine kinase
H7R57_RS12950	COG3118	belongs to the thioredoxin family
H7R57_RS12955	COG0471	metal ion transport
H7R57_RS12960	COG0058	SHG alpha-glucan phosphorylase activity
H7R57_RS12980	COG4584	PFAM Integrase catalytic
H7R57_RS12985	COG1484	DNA-dependent DNA replication
H7R57_RS12995	COG1882	Formate acetyltransferase
H7R57_RS13000	COG2116	formate transmembrane transporter activity
H7R57_RS13005	COG1944	ATP diphosphatase activity
H7R57_RS13010	COG2723	6-phospho-beta-galactosidase activity
H7R57_RS13015	COG0583	DNA-binding transcription factor activity
H7R57_RS13030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7R57_RS13035	COG0583	DNA-binding transcription factor activity
H7R57_RS13045	COG1335	isochorismatase
H7R57_RS13060	COG0583	DNA-binding transcription factor activity
H7R57_RS13065	COG2910	NAD(P)H-binding
H7R57_RS13080	COG1022	Amp-dependent synthetase and ligase
H7R57_RS13095	COG0861	Integral membrane protein TerC family
H7R57_RS13100	COG2885	chlorophyll binding
H7R57_RS13125	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7R57_RS13135	COG3768	UPF0283 membrane protein
H7R57_RS13140	COG3106	COG3106 Predicted ATPase
H7R57_RS13155	COG1842	Phage shock protein A
H7R57_RS13160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7R57_RS13185	COG4172	Belongs to the ABC transporter superfamily
H7R57_RS13190	COG0326	Molecular chaperone. Has ATPase activity
H7R57_RS13195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7R57_RS13215	COG1435	thymidine kinase activity
H7R57_RS13220	COG1757	Na H antiporter
H7R57_RS13225	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R57_RS13230	COG2096	Adenosyltransferase
H7R57_RS13235	COG3530	Putative quorum-sensing-regulated virulence factor
H7R57_RS13240	COG0602	queuosine metabolic process
H7R57_RS13245	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7R57_RS13265	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7R57_RS13275	COG0776	regulation of translation
H7R57_RS13280	COG0539	negative regulation of cytoplasmic translation
H7R57_RS13285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7R57_RS13290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R57_RS13305	COG2814	Major facilitator Superfamily
H7R57_RS13325	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H7R57_RS13330	COG3300	MHYT domain
H7R57_RS13330	COG5001	Diguanylate cyclase
H7R57_RS13335	COG0583	DNA-binding transcription factor activity
H7R57_RS13340	COG3437	response regulator, receiver
H7R57_RS13350	COG3385	transposase activity
H7R57_RS13370	COG4989	oxidoreductase activity
H7R57_RS13375	COG0724	RNA recognition motif
H7R57_RS13390	COG0765	amino acid transport
H7R57_RS13395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R57_RS13400	COG4597	amino acid ABC transporter
H7R57_RS13405	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H7R57_RS13415	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H7R57_RS13430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R57_RS13435	COG1360	Flagellar Motor Protein
H7R57_RS13440	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R57_RS13445	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R57_RS13450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R57_RS13450	COG0649	NAD binding
H7R57_RS13465	COG1034	ATP synthesis coupled electron transport
H7R57_RS13470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7R57_RS13475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R57_RS13480	COG0839	Belongs to the complex I subunit 6 family
H7R57_RS13485	COG0713	ATP synthesis coupled electron transport
H7R57_RS13495	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R57_RS13500	COG1007	ATP synthesis coupled electron transport
H7R57_RS13505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7R57_RS13505	COG0047	phosphoribosylformylglycinamidine synthase activity
H7R57_RS13510	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R57_RS13520	COG1645	bacterial-type flagellum-dependent swarming motility
H7R57_RS13525	COG1160	GTP binding
H7R57_RS13530	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R57_RS13535	COG2976	Protein conserved in bacteria
H7R57_RS13540	COG0124	histidyl-tRNA synthetase
H7R57_RS13550	COG1426	Protein conserved in bacteria
H7R57_RS13560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7R57_RS13565	COG0105	UTP biosynthetic process
H7R57_RS13575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R57_RS13585	COG0633	Ferredoxin
H7R57_RS13590	COG0443	Heat shock 70 kDa protein
H7R57_RS13595	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R57_RS13605	COG0822	iron-sulfur transferase activity
H7R57_RS13610	COG1104	cysteine desulfurase activity
H7R57_RS13615	COG1959	2 iron, 2 sulfur cluster binding
H7R57_RS13630	COG3154	lipid carrier protein
H7R57_RS13635	COG0826	peptidase U32
H7R57_RS13640	COG0826	peptidase U32
H7R57_RS13655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R57_RS13660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R57_RS13665	COG1862	Preprotein translocase
H7R57_RS13670	COG0343	queuine tRNA-ribosyltransferase activity
H7R57_RS13675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7R57_RS13680	COG0517	IMP dehydrogenase activity
H7R57_RS13680	COG1125	glycine betaine transport
H7R57_RS13690	COG3634	alkyl hydroperoxide reductase activity
H7R57_RS13715	COG1484	DNA-dependent DNA replication
H7R57_RS13720	COG4584	PFAM Integrase catalytic
H7R57_RS13765	COG1242	4 iron, 4 sulfur cluster binding
H7R57_RS13770	COG0067	glutamate synthase
H7R57_RS13770	COG0070	glutamate synthase
H7R57_RS13770	COG0069	glutamate synthase activity
H7R57_RS13775	COG0493	'glutamate synthase
H7R57_RS13780	COG1126	abc transporter atp-binding protein
H7R57_RS13785	COG0765	amino acid transport
H7R57_RS13790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R57_RS13805	COG0513	Belongs to the DEAD box helicase family
H7R57_RS13820	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H7R57_RS13830	COG0023	Translation Initiation Factor
H7R57_RS13835	COG2119	membrane
H7R57_RS13895	COG0215	cysteine-tRNA ligase activity
H7R57_RS13900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R57_RS13910	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R57_RS13915	COG2261	transglycosylase associated protein
H7R57_RS13920	COG0642	Histidine kinase
H7R57_RS13985	COG2314	TM2 domain
H7R57_RS14000	COG1484	DNA-dependent DNA replication
H7R57_RS14005	COG4584	PFAM Integrase catalytic
H7R57_RS14025	COG1484	DNA-dependent DNA replication
H7R57_RS14030	COG4584	PFAM Integrase catalytic
H7R57_RS14035	COG0582	viral genome integration into host DNA
H7R57_RS14150	COG0582	viral genome integration into host DNA
H7R57_RS14175	COG0322	excinuclease ABC activity
H7R57_RS14180	COG2197	response regulator
H7R57_RS14185	COG3385	transposase activity
H7R57_RS14190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7R57_RS14195	COG2835	tetraacyldisaccharide 4'-kinase activity
H7R57_RS14200	COG1663	tetraacyldisaccharide 4'-kinase activity
H7R57_RS14210	COG0658	competence protein
H7R57_RS14210	COG2333	competence protein COMEC
H7R57_RS14225	COG1448	Aminotransferase
H7R57_RS14235	COG0583	DNA-binding transcription factor activity
H7R57_RS14240	COG3085	chromosome segregation
H7R57_RS14245	COG4574	serine-type endopeptidase inhibitor activity
H7R57_RS14250	COG0584	glycerophosphoryl diester phosphodiesterase
H7R57_RS14260	COG1349	DNA-binding transcription factor activity
H7R57_RS14270	COG1484	DNA-dependent DNA replication
H7R57_RS14275	COG4584	PFAM Integrase catalytic
H7R57_RS14290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R57_RS14295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7R57_RS14300	COG0840	transmembrane signaling receptor activity
H7R57_RS14310	COG0583	DNA-binding transcription factor activity
H7R57_RS14330	COG0656	L-ascorbic acid biosynthetic process
H7R57_RS14335	COG2814	Major facilitator Superfamily
H7R57_RS14340	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R57_RS14355	COG3220	belongs to the UPF0276 family
H7R57_RS14375	COG1294	oxidase, subunit
H7R57_RS14385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R57_RS14395	COG2979	Protein of unknown function (DUF533)
H7R57_RS14410	COG0583	DNA-binding transcription factor activity
H7R57_RS14420	COG2807	transmembrane transport
H7R57_RS14425	COG1187	pseudouridine synthase activity
H7R57_RS14445	COG1403	HNH endonuclease
H7R57_RS14450	COG4657	Part of a membrane complex involved in electron transport
H7R57_RS14455	COG2878	Part of a membrane complex involved in electron transport
H7R57_RS14465	COG4658	electron transport chain
H7R57_RS14470	COG4659	FMN binding
H7R57_RS14475	COG4660	Part of a membrane complex involved in electron transport
H7R57_RS14480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7R57_RS14485	COG0346	lactoylglutathione lyase activity
H7R57_RS14500	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H7R57_RS14515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7R57_RS14520	COG0505	Belongs to the CarA family
H7R57_RS14525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7R57_RS14535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7R57_RS14540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7R57_RS14545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R57_RS14550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7R57_RS14555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R57_RS14585	COG2020	methyltransferase activity
H7R57_RS14590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R57_RS14595	COG0861	Integral membrane protein TerC family
H7R57_RS14610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R57_RS14615	COG0601	transmembrane transport
H7R57_RS14625	COG2095	MarC family integral membrane protein
H7R57_RS14630	COG1012	belongs to the aldehyde dehydrogenase family
H7R57_RS14630	COG1454	alcohol dehydrogenase
H7R57_RS14635	COG0217	transcriptional regulatory protein
H7R57_RS14640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7R57_RS14650	COG1801	Protein of unknown function DUF72
H7R57_RS14655	COG4106	trans-aconitate 2-methyltransferase activity
H7R57_RS14660	COG0500	methyltransferase
H7R57_RS14685	COG0450	alkyl hydroperoxide reductase
H7R57_RS14690	COG0583	DNA-binding transcription factor activity
H7R57_RS14695	COG0791	NLP P60 protein
H7R57_RS14705	COG0538	isocitrate dehydrogenase activity
H7R57_RS14710	COG2207	Transcriptional regulator
H7R57_RS14735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R57_RS14750	COG3152	Membrane
H7R57_RS14755	COG2814	Major facilitator Superfamily
H7R57_RS14760	COG0109	protoheme IX farnesyltransferase activity
H7R57_RS14765	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H7R57_RS14770	COG1845	cytochrome c oxidase, subunit III
H7R57_RS14775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H7R57_RS14780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H7R57_RS14790	COG2010	Cytochrome c
H7R57_RS14815	COG1309	transcriptional regulator
H7R57_RS14825	COG1454	alcohol dehydrogenase
H7R57_RS14845	COG0534	Mate efflux family protein
H7R57_RS14855	COG2841	Protein conserved in bacteria
H7R57_RS14860	COG3132	Protein of unknown function, DUF480
H7R57_RS14890	COG0708	Exodeoxyribonuclease III
H7R57_RS14910	COG1122	ATPase activity
H7R57_RS14915	COG1122	ATPase activity
H7R57_RS14935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R57_RS14940	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R57_RS14950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R57_RS14955	COG1120	ATPase activity
H7R57_RS14960	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R57_RS14965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R57_RS14970	COG2375	cellular response to nickel ion
H7R57_RS14975	COG0784	Response regulator, receiver
H7R57_RS14975	COG3437	response regulator, receiver
H7R57_RS14985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R57_RS14990	COG0328	RNA-DNA hybrid ribonuclease activity
H7R57_RS14995	COG2226	methyltransferase
H7R57_RS15000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R57_RS15005	COG1388	LysM domain
H7R57_RS15005	COG0741	lytic transglycosylase activity
H7R57_RS15030	COG0582	viral genome integration into host DNA
H7R57_RS15040	COG4584	PFAM Integrase catalytic
H7R57_RS15045	COG1484	DNA-dependent DNA replication
H7R57_RS15050	COG3012	SEC-C Motif Domain Protein
H7R57_RS15050	COG3318	Belongs to the UPF0149 family
H7R57_RS15060	COG1388	LysM domain
H7R57_RS15060	COG1376	ErfK ybiS ycfS ynhG family protein
H7R57_RS15070	COG0471	metal ion transport
H7R57_RS15080	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H7R57_RS15085	COG0791	NLP P60 protein
H7R57_RS15095	COG3118	belongs to the thioredoxin family
H7R57_RS15105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R57_RS15110	COG0788	formyltetrahydrofolate deformylase activity
H7R57_RS15135	COG0741	lytic transglycosylase activity
H7R57_RS15135	COG1196	nuclear chromosome segregation
H7R57_RS15135	COG0739	heme binding
H7R57_RS15140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R57_RS15150	COG0436	Aminotransferase
H7R57_RS15160	COG1288	antiporter activity
H7R57_RS15170	COG1879	ABC-type sugar transport system periplasmic component
H7R57_RS15180	COG0406	alpha-ribazole phosphatase activity
H7R57_RS15185	COG2964	Protein conserved in bacteria
H7R57_RS15190	COG3681	Belongs to the UPF0597 family
H7R57_RS15200	COG0814	amino acid
H7R57_RS15220	COG1166	arginine decarboxylase activity
H7R57_RS15225	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R57_RS15255	COG0583	DNA-binding transcription factor activity
H7R57_RS15265	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H7R57_RS15270	COG0840	transmembrane signaling receptor activity
H7R57_RS15275	COG0302	gtp cyclohydrolase
H7R57_RS15280	COG0303	'Molybdopterin
H7R57_RS15285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R57_RS15295	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7R57_RS15310	COG0314	molybdopterin synthase activity
H7R57_RS15315	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7R57_RS15320	COG0315	cyclic pyranopterin monophosphate synthase activity
H7R57_RS15325	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R57_RS15330	COG3005	denitrification pathway
H7R57_RS15340	COG0348	domain, Protein
H7R57_RS15345	COG0437	4 iron, 4 sulfur cluster binding
H7R57_RS15350	COG0243	molybdopterin cofactor binding
H7R57_RS15360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R57_RS15365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7R57_RS15370	COG3850	Histidine kinase
H7R57_RS15375	COG2197	response regulator
H7R57_RS15405	COG0121	glutamine amidotransferase
H7R57_RS15410	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R57_RS15415	COG1960	acyl-CoA dehydrogenase activity
H7R57_RS15420	COG1473	amidohydrolase
H7R57_RS15425	COG2914	Belongs to the UPF0125 (RnfH) family
H7R57_RS15430	COG2867	negative regulation of translational initiation
H7R57_RS15435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7R57_RS15625	COG3645	SOS response
H7R57_RS15625	COG3646	Phage regulatory protein
H7R57_RS15720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R57_RS15760	COG2974	May be involved in recombination
H7R57_RS15810	COG0582	viral genome integration into host DNA
H7R57_RS15815	COG0582	viral genome integration into host DNA
H7R57_RS15835	COG0477	Major facilitator Superfamily
H7R57_RS15835	COG2814	Major facilitator Superfamily
H7R57_RS15840	COG0457	Tetratricopeptide repeat
H7R57_RS15845	COG1940	carbohydrate kinase activity
H7R57_RS15850	COG3383	formate dehydrogenase (NAD+) activity
H7R57_RS15900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R57_RS15915	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H7R57_RS15945	COG3706	GGDEF domain
H7R57_RS15955	COG3447	MASE1 domain protein
H7R57_RS15955	COG5001	Diguanylate cyclase
H7R57_RS15955	COG5002	protein histidine kinase activity
H7R57_RS15965	COG3311	Transcriptional regulator
H7R57_RS15970	COG4983	Phage plasmid primase, P4 family domain protein
H7R57_RS15985	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7R57_RS15995	COG1960	acyl-CoA dehydrogenase activity
H7R57_RS16000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7R57_RS16020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7R57_RS16025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R57_RS16025	COG1263	PTS System
H7R57_RS16030	COG1609	Transcriptional regulator
H7R57_RS16055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R57_RS16055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R57_RS16055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R57_RS16065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R57_RS16075	COG1187	pseudouridine synthase activity
H7R57_RS16080	COG1051	belongs to the nudix hydrolase family
H7R57_RS16085	COG0482	sulfurtransferase activity
H7R57_RS16090	COG2915	High frequency lysogenization protein hflD homolog
H7R57_RS16095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7R57_RS16100	COG2850	peptidyl-arginine hydroxylation
H7R57_RS16115	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H7R57_RS16130	COG1397	ADP-ribosylglycohydrolase
H7R57_RS16140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R57_RS16160	COG0625	glutathione transferase activity
H7R57_RS16165	COG0259	pyridoxamine-phosphate oxidase activity
H7R57_RS16185	COG4584	PFAM Integrase catalytic
H7R57_RS16190	COG1484	DNA-dependent DNA replication
H7R57_RS16200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R57_RS16205	COG1882	Formate acetyltransferase
H7R57_RS16225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R57_RS16225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R57_RS16235	COG1484	DNA-dependent DNA replication
H7R57_RS16240	COG4584	PFAM Integrase catalytic
H7R57_RS16255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7R57_RS16270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7R57_RS16295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R57_RS16300	COG1138	Cytochrome C-type biogenesis protein
H7R57_RS16305	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7R57_RS16310	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R57_RS16315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R57_RS16320	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R57_RS16335	COG0835	chemotaxis
H7R57_RS16345	COG1192	Involved in chromosome partitioning
H7R57_RS16350	COG1360	Flagellar Motor Protein
H7R57_RS16355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R57_RS16360	COG2201	protein-glutamate methylesterase activity
H7R57_RS16365	COG0643	Histidine kinase
H7R57_RS16365	COG0784	Response regulator, receiver
H7R57_RS16365	COG2198	Histidine kinase
H7R57_RS16370	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H7R57_RS16395	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7R57_RS16405	COG1684	flagellar biosynthetic protein fliR
H7R57_RS16460	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7R57_RS16470	COG1677	Flagellar hook-basal body complex protein FliE
H7R57_RS16480	COG0469	pyruvate kinase activity
H7R57_RS16485	COG1737	Transcriptional regulator
H7R57_RS16520	COG2233	PERMEase
H7R57_RS16540	COG0281	malic enzyme
H7R57_RS16545	COG0745	RESPONSE REGULATOR receiver
H7R57_RS16555	COG0437	4 iron, 4 sulfur cluster binding
H7R57_RS16560	COG3383	formate dehydrogenase (NAD+) activity
H7R57_RS16560	COG3383	formate dehydrogenase (NAD+) activity
H7R57_RS16595	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7R57_RS16610	COG2204	response regulator
H7R57_RS16620	COG4662	Binding-protein-dependent transport system inner membrane component
H7R57_RS16625	COG1136	(ABC) transporter
H7R57_RS16630	COG0746	molybdenum cofactor guanylyltransferase activity
H7R57_RS16635	COG0303	'Molybdopterin
H7R57_RS16640	COG1289	transmembrane transporter activity
H7R57_RS16650	COG1484	DNA-dependent DNA replication
H7R57_RS16655	COG4584	PFAM Integrase catalytic
H7R57_RS16700	COG0784	Response regulator, receiver
H7R57_RS16700	COG2205	protein histidine kinase activity
H7R57_RS16705	COG4166	transmembrane transport
H7R57_RS16710	COG0601	transmembrane transport
H7R57_RS16715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R57_RS16720	COG0444	Belongs to the ABC transporter superfamily
H7R57_RS16725	COG4608	Belongs to the ABC transporter superfamily
H7R57_RS16735	COG2971	BadF BadG BcrA BcrD
H7R57_RS16780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7R57_RS16785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7R57_RS16795	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H7R57_RS16800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7R57_RS16810	COG0180	Tryptophanyl-tRNA synthetase
H7R57_RS16825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7R57_RS16835	COG1012	belongs to the aldehyde dehydrogenase family
H7R57_RS16850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R57_RS16860	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7R57_RS16860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7R57_RS16860	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7R57_RS16860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R57_RS16865	COG0366	Alpha amylase catalytic
H7R57_RS16875	COG3097	Belongs to the UPF0267 family
H7R57_RS16885	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H7R57_RS16895	COG0471	metal ion transport
H7R57_RS16895	COG0490	domain, Protein
H7R57_RS16945	COG0583	DNA-binding transcription factor activity
H7R57_RS16950	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7R57_RS16955	COG3842	ATPase activity
H7R57_RS16960	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R57_RS16965	COG1177	transmembrane transport
H7R57_RS16970	COG1012	belongs to the aldehyde dehydrogenase family
H7R57_RS16975	COG0012	GTP binding
H7R57_RS16980	COG0193	aminoacyl-tRNA hydrolase activity
H7R57_RS16985	COG0737	Belongs to the 5'-nucleotidase family
H7R57_RS16990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7R57_RS17000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7R57_RS17005	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H7R57_RS17010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7R57_RS17015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7R57_RS17020	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R57_RS17030	COG2912	Transglutaminase-like superfamily
H7R57_RS17035	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7R57_RS17040	COG1301	dicarboxylic acid transport
H7R57_RS17055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7R57_RS17065	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H7R57_RS17065	COG3408	Glycogen debranching enzyme
H7R57_RS17075	COG1881	PFAM PEBP family protein
H7R57_RS17080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7R57_RS17095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7R57_RS17105	COG0583	DNA-binding transcription factor activity
H7R57_RS17110	COG1028	Short-chain dehydrogenase reductase Sdr
H7R57_RS17115	COG0616	signal peptide processing
H7R57_RS17120	COG2211	Major facilitator Superfamily
H7R57_RS17125	COG2203	Gaf domain
H7R57_RS17125	COG2199	diguanylate cyclase activity
H7R57_RS17130	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R57_RS17140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R57_RS17145	COG0826	peptidase U32
H7R57_RS17150	COG2199	diguanylate cyclase activity
H7R57_RS17150	COG2203	Gaf domain
H7R57_RS17150	COG2200	EAL domain
H7R57_RS17175	COG5433	transposase activity
H7R57_RS17185	COG2197	response regulator
H7R57_RS17190	COG0784	Response regulator, receiver
H7R57_RS17190	COG2205	protein histidine kinase activity
H7R57_RS17190	COG5002	protein histidine kinase activity
H7R57_RS17215	COG3724	N-succinylarginine dihydrolase activity
H7R57_RS17240	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7R57_RS17245	COG0583	DNA-binding transcription factor activity
H7R57_RS17265	COG0583	DNA-binding transcription factor activity
H7R57_RS17275	COG0739	heme binding
H7R57_RS17285	COG3264	Mechanosensitive ion channel
H7R57_RS17285	COG1511	domain protein
H7R57_RS17290	COG0584	glycerophosphoryl diester phosphodiesterase
H7R57_RS17310	COG1053	succinate dehydrogenase
H7R57_RS17315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7R57_RS17320	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R57_RS17325	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R57_RS17330	COG3366	ferrous iron transmembrane transporter activity
H7R57_RS17335	COG0700	Nucleoside recognition
H7R57_RS17340	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R57_RS17350	COG3214	Protein conserved in bacteria
H7R57_RS17365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R57_RS17370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R57_RS17395	COG1028	Short-chain dehydrogenase reductase Sdr
H7R57_RS17420	COG0516	GMP reductase activity
H7R57_RS17430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7R57_RS17440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R57_RS17450	COG0583	DNA-binding transcription factor activity
H7R57_RS17455	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7R57_RS17465	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R57_RS17490	COG3706	GGDEF domain
H7R57_RS17500	COG1335	isochorismatase
H7R57_RS17510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R57_RS17515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R57_RS17520	COG1702	phosphate starvation-inducible protein PhoH
H7R57_RS17525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7R57_RS17530	COG4535	Mg2 and Co2 transporter CorC
H7R57_RS17535	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7R57_RS17560	COG1970	mechanosensitive ion channel activity
H7R57_RS17565	COG4974	Belongs to the 'phage' integrase family
H7R57_RS17570	COG0716	FMN binding
H7R57_RS17580	COG0312	modulator of DNA gyrase
H7R57_RS17590	COG2888	peptidyl-tyrosine sulfation
H7R57_RS17595	COG0495	leucyl-tRNA aminoacylation
H7R57_RS17610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7R57_RS17615	COG0799	negative regulation of ribosome biogenesis
H7R57_RS17620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7R57_RS17625	COG0768	penicillin binding
H7R57_RS17630	COG0772	Belongs to the SEDS family
H7R57_RS17635	COG2951	lytic endotransglycosylase activity
H7R57_RS17640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7R57_RS17645	COG1686	Belongs to the peptidase S11 family
H7R57_RS17650	COG2921	Belongs to the UPF0250 family
H7R57_RS17655	COG0321	lipoyl(octanoyl) transferase activity
H7R57_RS17660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7R57_RS17680	COG3139	Protein of unknown function (DUF1315)
H7R57_RS17685	COG0252	asparaginase activity
H7R57_RS17690	COG0786	glutamate:sodium symporter activity
H7R57_RS17705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7R57_RS17710	COG0384	phenazine biosynthesis protein PhzF
H7R57_RS17715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7R57_RS17720	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R57_RS17725	COG0175	sulfate reduction
H7R57_RS17740	COG2966	Psort location CytoplasmicMembrane, score
H7R57_RS17750	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R57_RS17765	COG2897	thiosulfate sulfurtransferase activity
H7R57_RS17770	COG2066	Belongs to the glutaminase family
H7R57_RS17775	COG3171	Protein conserved in bacteria
H7R57_RS17780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7R57_RS17785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R57_RS17795	COG1090	epimerase
H7R57_RS17800	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H7R57_RS17805	COG4181	ATPase activity
H7R57_RS17810	COG2755	lipolytic protein G-D-S-L family
H7R57_RS17815	COG0835	chemotaxis
H7R57_RS17815	COG0784	Response regulator, receiver
H7R57_RS17855	COG3397	chitin binding
H7R57_RS17870	COG0784	Response regulator, receiver
H7R57_RS17870	COG2205	protein histidine kinase activity
H7R57_RS17870	COG5002	protein histidine kinase activity
H7R57_RS17880	COG3655	Transcriptional regulator
H7R57_RS17890	COG2814	Major facilitator Superfamily
H7R57_RS17915	COG0748	coenzyme F420 binding
H7R57_RS17920	COG3721	Heme iron utilization protein
H7R57_RS17930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R57_RS17955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R57_RS17990	COG2204	response regulator
H7R57_RS17995	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R57_RS18010	COG1047	Peptidyl-prolyl cis-trans
H7R57_RS18015	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H7R57_RS18025	COG0784	Response regulator, receiver
H7R57_RS18025	COG0835	chemotaxis
H7R57_RS18030	COG0429	hydrolase of the alpha beta-hydrolase fold
H7R57_RS18035	COG2203	Gaf domain
H7R57_RS18035	COG5001	Diguanylate cyclase
H7R57_RS18035	COG4251	negative regulation of phosphorylation
H7R57_RS18035	COG3706	GGDEF domain
H7R57_RS18040	COG3089	Belongs to the UPF0270 family
H7R57_RS18045	COG3954	Phosphoribulokinase
H7R57_RS18060	COG1765	OsmC-like protein
H7R57_RS18100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R57_RS18105	COG2313	pseudouridylate synthase activity
H7R57_RS18140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7R57_RS18155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R57_RS18165	COG2986	histidine ammonia-lyase
H7R57_RS18190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7R57_RS18195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R57_RS18200	COG1028	Short-chain dehydrogenase reductase Sdr
H7R57_RS18205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7R57_RS18225	COG0582	viral genome integration into host DNA
H7R57_RS18240	COG1484	DNA-dependent DNA replication
H7R57_RS18245	COG4584	PFAM Integrase catalytic
H7R57_RS18270	COG4974	Belongs to the 'phage' integrase family
H7R57_RS18295	COG2203	Gaf domain
H7R57_RS18295	COG3706	GGDEF domain
H7R57_RS18295	COG5001	Diguanylate cyclase
H7R57_RS18295	COG4251	negative regulation of phosphorylation
H7R57_RS18305	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
H7R57_RS18330	COG0569	domain protein
H7R57_RS18330	COG2985	domain, Protein
H7R57_RS18335	COG1272	protein, Hemolysin III
H7R57_RS18340	COG0076	glutamate decarboxylase activity
H7R57_RS18345	COG2917	probably involved in intracellular septation
H7R57_RS18350	COG2350	Protein conserved in bacteria
H7R57_RS18360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7R57_RS18365	COG1381	Involved in DNA repair and RecF pathway recombination
H7R57_RS18380	COG0681	Belongs to the peptidase S26 family
H7R57_RS18385	COG0481	GTPase activity
H7R57_RS18395	COG3026	antisigma factor binding
H7R57_RS18400	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H7R57_RS18405	COG1595	DNA-templated transcription, initiation
H7R57_RS18410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7R57_RS18425	COG0354	folic acid binding
H7R57_RS18470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R57_RS18480	COG0126	phosphoglycerate kinase activity
H7R57_RS18485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R57_RS18490	COG1940	carbohydrate kinase activity
H7R57_RS18495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7R57_RS18510	COG4991	sh3 domain protein
H7R57_RS18515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R57_RS18530	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7R57_RS18565	COG2816	NAD+ diphosphatase activity
H7R57_RS18605	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
H7R57_RS18615	COG2199	diguanylate cyclase activity
H7R57_RS18615	COG2203	Gaf domain
H7R57_RS18620	COG0513	Belongs to the DEAD box helicase family
H7R57_RS18635	COG0471	metal ion transport
H7R57_RS18650	COG0154	amidase activity
H7R57_RS18655	COG2957	Belongs to the agmatine deiminase family
H7R57_RS18665	COG2852	Protein conserved in bacteria
H7R57_RS18675	COG1902	pentaerythritol trinitrate reductase activity
H7R57_RS18685	COG1388	LysM domain
H7R57_RS18685	COG4942	peptidase
H7R57_RS18690	COG1238	metal cluster binding
H7R57_RS18695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7R57_RS18700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7R57_RS18705	COG0585	pseudouridine synthase activity
H7R57_RS18715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7R57_RS18720	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7R57_RS18725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R57_RS18735	COG1376	ErfK ybiS ycfS ynhG family protein
H7R57_RS18740	COG0668	transmembrane transport
H7R57_RS18750	COG2731	YhcH YjgK YiaL family protein
H7R57_RS18760	COG1794	racemase activity, acting on amino acids and derivatives
H7R57_RS18775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R57_RS18795	COG0488	(ABC) transporter
H7R57_RS18805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7R57_RS18825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7R57_RS18835	COG0148	phosphopyruvate hydratase activity
H7R57_RS18840	COG0504	CTP synthase activity
H7R57_RS18845	COG3956	TIGRFAM MazG family protein
H7R57_RS18850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R57_RS18855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R57_RS18865	COG4807	Protein conserved in bacteria
H7R57_RS18870	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7R57_RS18875	COG0783	Belongs to the Dps family
H7R57_RS18880	COG1151	hydroxylamine reductase activity
H7R57_RS18885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R57_RS18890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R57_RS18895	COG0671	phosphoesterase, PA-phosphatase related
H7R57_RS18900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R57_RS18905	COG0163	prenyltransferase activity
H7R57_RS18920	COG1131	(ABC) transporter
H7R57_RS18925	COG0842	Transport permease protein
H7R57_RS18930	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
H7R57_RS18935	COG1924	4 iron, 4 sulfur cluster binding
H7R57_RS18960	COG1486	melibiose metabolic process
H7R57_RS18975	COG1823	symporter activity
H7R57_RS18985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7R57_RS18990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7R57_RS18995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7R57_RS19005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R57_RS19010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7R57_RS19015	COG1489	DNA binding
H7R57_RS19025	COG1643	Atp-dependent helicase
H7R57_RS19030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R57_RS19035	COG0346	lactoylglutathione lyase activity
H7R57_RS19040	COG2076	Multidrug Resistance protein
H7R57_RS19045	COG2076	Multidrug Resistance protein
H7R57_RS19055	COG0784	Response regulator, receiver
H7R57_RS19055	COG3437	response regulator, receiver
H7R57_RS19060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7R57_RS19075	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H7R57_RS19115	COG1484	DNA-dependent DNA replication
H7R57_RS19120	COG4584	PFAM Integrase catalytic
H7R57_RS19135	COG0529	Catalyzes the synthesis of activated sulfate
H7R57_RS19140	COG2895	sulfate adenylyltransferase (ATP) activity
H7R57_RS19145	COG0175	sulfate reduction
H7R57_RS19150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R57_RS19150	COG1648	precorrin-2 dehydrogenase activity
H7R57_RS19155	COG0330	HflC and HflK could
H7R57_RS19160	COG1585	Membrane protein implicated in regulation of membrane protease activity
H7R57_RS19165	COG0840	transmembrane signaling receptor activity
H7R57_RS19170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7R57_RS19180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R57_RS19185	COG1640	4-alpha-glucanotransferase
H7R57_RS19190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7R57_RS19210	COG1051	belongs to the nudix hydrolase family
H7R57_RS19235	COG0561	phosphatase activity
H7R57_RS19250	COG0733	neurotransmitter:sodium symporter activity
H7R57_RS19260	COG0733	neurotransmitter:sodium symporter activity
H7R57_RS19325	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H7R57_RS19330	COG2885	chlorophyll binding
H7R57_RS19335	COG0823	Involved in the tonB-independent uptake of proteins
H7R57_RS19350	COG0811	peptide transport
H7R57_RS19355	COG0824	Thioesterase
H7R57_RS19360	COG3790	cyd operon protein YbgE
H7R57_RS19365	COG4890	Cyd operon protein YbgT
H7R57_RS19370	COG1294	oxidase, subunit
H7R57_RS19380	COG2255	four-way junction helicase activity
H7R57_RS19385	COG0632	four-way junction helicase activity
H7R57_RS19390	COG0840	transmembrane signaling receptor activity
H7R57_RS19400	COG2771	luxR family
H7R57_RS19405	COG3916	Acyl-homoserine-lactone synthase
H7R57_RS19415	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H7R57_RS19420	COG2203	Gaf domain
H7R57_RS19420	COG3706	GGDEF domain
H7R57_RS19420	COG4251	negative regulation of phosphorylation
H7R57_RS19420	COG5001	Diguanylate cyclase
H7R57_RS19430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R57_RS19440	COG2995	paraquat-inducible protein a
H7R57_RS19445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R57_RS19445	COG3008	intermembrane lipid transfer
H7R57_RS19450	COG3009	Protein conserved in bacteria
H7R57_RS19455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R57_RS19460	COG0442	prolyl-tRNA aminoacylation
H7R57_RS19470	COG1309	transcriptional regulator
H7R57_RS19485	COG4221	oxidoreductase activity
H7R57_RS19500	COG1024	Enoyl-CoA hydratase
H7R57_RS19510	COG0110	maltose O-acetyltransferase activity
H7R57_RS19520	COG4166	transmembrane transport
H7R57_RS19530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R57_RS19535	COG0735	belongs to the Fur family
H7R57_RS19560	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7R57_RS19565	COG0513	Belongs to the DEAD box helicase family
H7R57_RS19570	COG2153	protein acetylation
H7R57_RS19585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R57_RS19590	COG0557	exoribonuclease II activity
H7R57_RS19595	COG3706	GGDEF domain
H7R57_RS19605	COG3240	lipase activity
H7R57_RS19620	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H7R57_RS19625	COG1194	a g-specific adenine glycosylase
H7R57_RS19630	COG0617	tRNA 3'-terminal CCA addition
H7R57_RS19650	COG3068	Protein conserved in bacteria
H7R57_RS19660	COG0739	heme binding
H7R57_RS19680	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H7R57_RS19685	COG1121	(ABC) transporter
H7R57_RS19690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7R57_RS19695	COG0583	DNA-binding transcription factor activity
H7R57_RS19700	COG0697	spore germination
H7R57_RS19705	COG1573	uracil-dna glycosylase
H7R57_RS19720	COG2827	Endonuclease containing a URI domain
H7R57_RS19735	COG1842	Phage shock protein A
H7R57_RS19740	COG0204	Acyl-transferase
H7R57_RS19760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R57_RS19765	COG0583	DNA-binding transcription factor activity
H7R57_RS19800	COG3104	oligopeptide transport
H7R57_RS19820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7R57_RS19840	COG0187	DNA topoisomerase II activity
H7R57_RS19845	COG1289	transmembrane transporter activity
H7R57_RS19850	COG1566	PFAM secretion protein HlyD family protein
H7R57_RS19870	COG1051	belongs to the nudix hydrolase family
H7R57_RS19875	COG3150	esterase
H7R57_RS19885	COG3151	Protein conserved in bacteria
H7R57_RS19890	COG0494	nUDIX hydrolase
H7R57_RS19895	COG1538	Outer membrane efflux protein
H7R57_RS19900	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7R57_RS19900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7R57_RS19905	COG1560	Kdo2-lipid A biosynthetic process
H7R57_RS19910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R57_RS19910	COG2213	PTS system mannitol-specific
H7R57_RS19915	COG0246	Mannitol dehydrogenase
H7R57_RS19920	COG3722	fumarate hydratase activity
H7R57_RS19945	COG1671	Belongs to the UPF0178 family
H7R57_RS19960	COG1988	membrane-bound metal-dependent
H7R57_RS19965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R57_RS19975	COG0513	Belongs to the DEAD box helicase family
H7R57_RS19995	COG1575	Belongs to the MenA family. Type 1 subfamily
H7R57_RS20000	COG1169	isochorismate synthase
H7R57_RS20005	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H7R57_RS20010	COG0596	Alpha beta hydrolase
H7R57_RS20015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7R57_RS20025	COG0318	PFAM AMP-dependent synthetase and ligase
H7R57_RS20040	COG3539	Fimbrial protein
H7R57_RS20050	COG3121	Chaperone
H7R57_RS20055	COG3188	usher protein
H7R57_RS20080	COG3291	Pkd domain containing protein
H7R57_RS20085	COG2949	membrane
H7R57_RS20090	COG0835	chemotaxis
H7R57_RS20090	COG0784	Response regulator, receiver
H7R57_RS20100	COG1444	tRNA N-acetyltransferase activity
H7R57_RS20120	COG1803	Methylglyoxal synthase
H7R57_RS20125	COG1979	alcohol dehydrogenase
H7R57_RS20140	COG4221	oxidoreductase activity
H7R57_RS20160	COG1285	pathogenesis
H7R57_RS20180	COG1368	sulfuric ester hydrolase activity
H7R57_RS20185	COG1522	sequence-specific DNA binding
H7R57_RS20195	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H7R57_RS20200	COG1418	mRNA catabolic process
H7R57_RS20205	COG1058	Belongs to the CinA family
H7R57_RS20205	COG1546	Belongs to the CinA family
H7R57_RS20215	COG0561	phosphatase activity
H7R57_RS20225	COG2926	Belongs to the UPF0265 family
H7R57_RS20245	COG1484	DNA-dependent DNA replication
H7R57_RS20250	COG4584	PFAM Integrase catalytic
H7R57_RS20280	COG3655	Transcriptional regulator
H7R57_RS20330	COG4584	PFAM Integrase catalytic
H7R57_RS20335	COG1484	DNA-dependent DNA replication
H7R57_RS20355	COG0840	transmembrane signaling receptor activity
H7R57_RS20360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R57_RS20400	COG4584	PFAM Integrase catalytic
H7R57_RS20405	COG1484	DNA-dependent DNA replication
H7R57_RS20465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R57_RS20470	COG0564	pseudouridine synthase activity
H7R57_RS20480	COG0110	maltose O-acetyltransferase activity
H7R57_RS20485	COG0366	Alpha amylase catalytic
H7R57_RS20490	COG1263	PTS System
H7R57_RS20490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R57_RS20510	COG0252	asparaginase activity
H7R57_RS20515	COG1253	flavin adenine dinucleotide binding
H7R57_RS20520	COG0586	Pfam SNARE associated Golgi protein
H7R57_RS20525	COG1686	Belongs to the peptidase S11 family
H7R57_RS20560	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7R57_RS20570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7R57_RS20580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7R57_RS20585	COG1546	Belongs to the CinA family
H7R57_RS20605	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H7R57_RS20625	COG0582	viral genome integration into host DNA
H7R57_RS20630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7R57_RS20635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7R57_RS20640	COG4667	esterase of the alpha-beta hydrolase superfamily
H7R57_RS20650	COG1346	cytolysis
H7R57_RS20655	COG1380	Effector of murein hydrolase LrgA
H7R57_RS20675	COG0583	DNA-binding transcription factor activity
H7R57_RS20705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7R57_RS20715	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7R57_RS20720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R57_RS20730	COG0137	argininosuccinate synthase activity
H7R57_RS20735	COG0165	Argininosuccinate lyase
H7R57_RS20750	COG3314	Sporulation integral membrane protein YlbJ
H7R57_RS20775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7R57_RS20780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7R57_RS20790	COG0477	Major facilitator Superfamily
H7R57_RS20795	COG0523	cobalamin synthesis protein
H7R57_RS20805	COG2200	EAL domain
H7R57_RS20810	COG1049	propionate catabolic process, 2-methylcitrate cycle
H7R57_RS20815	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R57_RS20820	COG0840	transmembrane signaling receptor activity
H7R57_RS20830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R57_RS20835	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R57_RS20840	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7R57_RS20845	COG2186	Transcriptional regulator
H7R57_RS20865	COG4969	Belongs to the N-Me-Phe pilin family
H7R57_RS20870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R57_RS20875	COG1459	type II secretion system
H7R57_RS20890	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H7R57_RS20895	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H7R57_RS20900	COG0494	nUDIX hydrolase
H7R57_RS20905	COG0653	protein targeting
H7R57_RS20915	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7R57_RS20920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7R57_RS20925	COG0849	cell division
H7R57_RS20935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R57_RS20940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7R57_RS20945	COG0772	Belongs to the SEDS family
H7R57_RS20950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7R57_RS20955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7R57_RS20960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7R57_RS20965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7R57_RS20970	COG0768	penicillin binding
H7R57_RS20975	COG3116	cell division
H7R57_RS20980	COG0275	rRNA processing
H7R57_RS20985	COG2001	Belongs to the MraZ family
H7R57_RS20995	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7R57_RS21000	COG3107	peptidoglycan biosynthetic process
H7R57_RS21005	COG0792	nuclease activity
H7R57_RS21010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R57_RS21020	COG2969	positive regulation of protein catabolic process
H7R57_RS21025	COG0625	glutathione transferase activity
H7R57_RS21030	COG2857	Cytochrome c1
H7R57_RS21035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7R57_RS21040	COG0723	plastoquinol--plastocyanin reductase activity
H7R57_RS21045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7R57_RS21050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7R57_RS21055	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7R57_RS21065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R57_RS21070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R57_RS21100	COG3964	amidohydrolase
H7R57_RS21115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R57_RS21115	COG3711	transcriptional antiterminator
H7R57_RS21120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R57_RS21125	COG1660	Displays ATPase and GTPase activities
H7R57_RS21130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R57_RS21140	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7R57_RS21145	COG1137	ATPase activity
H7R57_RS21150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7R57_RS21160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7R57_RS21165	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7R57_RS21165	COG0517	IMP dehydrogenase activity
H7R57_RS21170	COG1127	ABC transporter
H7R57_RS21175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7R57_RS21180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R57_RS21185	COG2854	intermembrane phospholipid transfer
H7R57_RS21195	COG5007	Belongs to the BolA IbaG family
H7R57_RS21200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7R57_RS21205	COG0312	modulator of DNA gyrase
H7R57_RS21210	COG3028	Belongs to the UPF0307 family
H7R57_RS21220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7R57_RS21230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R57_RS21235	COG1011	Hydrolase
H7R57_RS21250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7R57_RS21255	COG0019	diaminopimelate decarboxylase activity
H7R57_RS21265	COG1965	Belongs to the frataxin family
H7R57_RS21270	COG0400	carboxylic ester hydrolase activity
H7R57_RS21275	COG3072	Adenylate cyclase
H7R57_RS21280	COG0181	hydroxymethylbilane synthase activity
H7R57_RS21290	COG2959	enzyme of heme biosynthesis
H7R57_RS21305	COG1494	fructose-1,6-bisphosphatase
H7R57_RS21330	COG1686	Belongs to the peptidase S11 family
H7R57_RS21340	COG4584	PFAM Integrase catalytic
H7R57_RS21345	COG1484	DNA-dependent DNA replication
H7R57_RS21365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7R57_RS21375	COG3078	GTPase activator activity
H7R57_RS21385	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7R57_RS21395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7R57_RS21400	COG0408	coproporphyrinogen oxidase activity
H7R57_RS21405	COG0009	L-threonylcarbamoyladenylate synthase
H7R57_RS21415	COG0551	DNA topoisomerase type I activity
H7R57_RS21420	COG2922	Belongs to the Smg family
H7R57_RS21425	COG0758	DNA mediated transformation
H7R57_RS21430	COG1652	LysM domain
H7R57_RS21435	COG0242	peptide deformylase activity
H7R57_RS21440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7R57_RS21445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R57_RS21445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R57_RS21450	COG0569	domain protein
H7R57_RS21455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R57_RS21460	COG1217	gtp-binding protein TYPA
H7R57_RS21465	COG0174	glutamine synthetase
H7R57_RS21485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7R57_RS21490	COG1322	Protein conserved in bacteria
H7R57_RS21510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R57_RS21515	COG0583	DNA-binding transcription factor activity
H7R57_RS21520	COG0519	Catalyzes the synthesis of GMP from XMP
H7R57_RS21520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R57_RS21530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7R57_RS21535	COG1396	sequence-specific DNA binding
H7R57_RS21540	COG1012	belongs to the aldehyde dehydrogenase family
H7R57_RS21550	COG2962	Rard protein
H7R57_RS21555	COG0840	transmembrane signaling receptor activity
H7R57_RS21560	COG2391	methyltransferase activity
H7R57_RS21580	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R57_RS21590	COG3681	Belongs to the UPF0597 family
H7R57_RS21600	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H7R57_RS21605	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H7R57_RS21610	COG1979	alcohol dehydrogenase
H7R57_RS21615	COG2207	Transcriptional regulator
H7R57_RS21620	COG3040	lipid binding
H7R57_RS21635	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H7R57_RS21655	COG0583	DNA-binding transcription factor activity
H7R57_RS21660	COG0688	phosphatidylethanolamine metabolic process
H7R57_RS21675	COG0540	Belongs to the ATCase OTCase family
H7R57_RS21680	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H7R57_RS21685	COG1438	arginine binding
H7R57_RS21720	COG1401	restriction endodeoxyribonuclease activity
H7R57_RS21725	COG1401	restriction endodeoxyribonuclease activity
H7R57_RS21730	COG4584	PFAM Integrase catalytic
H7R57_RS21735	COG1484	DNA-dependent DNA replication
H7R57_RS21740	COG1401	restriction endodeoxyribonuclease activity
H7R57_RS21760	COG0129	dihydroxy-acid dehydratase activity
H7R57_RS21770	COG3978	acetolactate synthase activity
H7R57_RS21780	COG0606	chelatase, subunit chli
H7R57_RS21785	COG0204	Acyl-transferase
H7R57_RS21790	COG0204	Acyl-transferase
H7R57_RS21795	COG1683	Conserved Protein
H7R57_RS21805	COG1335	isochorismatase
H7R57_RS21815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R57_RS21820	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7R57_RS21830	COG3084	Protein conserved in bacteria
H7R57_RS21835	COG2203	Gaf domain
H7R57_RS21835	COG3706	GGDEF domain
H7R57_RS21835	COG4251	negative regulation of phosphorylation
H7R57_RS21835	COG5001	Diguanylate cyclase
H7R57_RS21850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7R57_RS21855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7R57_RS21860	COG1561	YicC-like family, N-terminal region
H7R57_RS21865	COG0583	DNA-binding transcription factor activity
H7R57_RS21880	COG0583	DNA-binding transcription factor activity
H7R57_RS21920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7R57_RS21925	COG0385	Bile acid
H7R57_RS21930	COG0531	amino acid
H7R57_RS21935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R57_RS21940	COG0531	amino acid
H7R57_RS21945	COG2731	YhcH YjgK YiaL family protein
H7R57_RS21950	COG3250	beta-galactosidase activity
H7R57_RS21955	COG1609	Transcriptional regulator
H7R57_RS21995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7R57_RS22000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R57_RS22000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R57_RS22005	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H7R57_RS22015	COG3074	FtsZ-dependent cytokinesis
H7R57_RS22025	COG1045	serine acetyltransferase
H7R57_RS22035	COG0745	RESPONSE REGULATOR receiver
H7R57_RS22040	COG2205	protein histidine kinase activity
H7R57_RS22045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7R57_RS22050	COG0534	Mate efflux family protein
H7R57_RS22065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R57_RS22070	COG2937	Belongs to the GPAT DAPAT family
H7R57_RS22075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7R57_RS22080	COG3161	chorismate lyase activity
H7R57_RS22085	COG1580	Controls the rotational direction of flagella during chemotaxis
H7R57_RS22100	COG0604	alcohol dehydrogenase
H7R57_RS22105	COG1609	Transcriptional regulator
H7R57_RS22110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R57_RS22125	COG1519	Transferase
H7R57_RS22130	COG0859	PFAM glycosyl transferase family 9
H7R57_RS22135	COG0463	Glycosyl transferase, family 2
H7R57_RS22140	COG0859	PFAM glycosyl transferase family 9
H7R57_RS22145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7R57_RS22150	COG2990	Protein conserved in bacteria
H7R57_RS22155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7R57_RS22165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7R57_RS22170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7R57_RS22175	COG2003	Belongs to the UPF0758 family
H7R57_RS22180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7R57_RS22185	COG0756	dUTP diphosphatase activity
H7R57_RS22190	COG1309	transcriptional regulator
H7R57_RS22195	COG0668	transmembrane transport
H7R57_RS22200	COG0166	Belongs to the GPI family
H7R57_RS22205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7R57_RS22265	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H7R57_RS22270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R57_RS22275	COG1739	Uncharacterized protein family UPF0029
H7R57_RS22280	COG0006	proline dipeptidase activity
H7R57_RS22290	COG4584	PFAM Integrase catalytic
H7R57_RS22295	COG1484	DNA-dependent DNA replication
H7R57_RS22305	COG1024	Enoyl-CoA hydratase
H7R57_RS22305	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R57_RS22310	COG0183	Belongs to the thiolase family
H7R57_RS22335	COG0425	Belongs to the sulfur carrier protein TusA family
H7R57_RS22340	COG0251	oxidation-reduction process
H7R57_RS22345	COG2885	chlorophyll binding
H7R57_RS22350	COG0840	transmembrane signaling receptor activity
H7R57_RS22355	COG2818	Glycosylase
H7R57_RS22360	COG0752	glycyl-tRNA synthetase alpha subunit
H7R57_RS22365	COG0751	glycine-tRNA ligase activity
H7R57_RS22380	COG5001	Diguanylate cyclase
H7R57_RS22380	COG4251	negative regulation of phosphorylation
H7R57_RS22380	COG3706	GGDEF domain
H7R57_RS22380	COG2203	Gaf domain
H7R57_RS22425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R57_RS22440	COG2960	long-chain fatty acid transporting porin activity
H7R57_RS22445	COG5002	protein histidine kinase activity
H7R57_RS22445	COG5001	Diguanylate cyclase
H7R57_RS22455	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7R57_RS22470	COG3118	belongs to the thioredoxin family
H7R57_RS22475	COG0513	Belongs to the DEAD box helicase family
H7R57_RS22480	COG0248	Ppx GppA phosphatase
H7R57_RS22490	COG0742	ribosomal rna small subunit methyltransferase
H7R57_RS22495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R57_RS22510	COG3469	chitinase activity
H7R57_RS22520	COG0084	hydrolase, TatD family'
H7R57_RS22525	COG0805	protein transport
H7R57_RS22530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R57_RS22540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7R57_RS22550	COG2226	methyltransferase
H7R57_RS22555	COG0402	S-adenosylhomocysteine deaminase activity
H7R57_RS22605	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H7R57_RS22610	COG0848	biopolymer transport protein
H7R57_RS22615	COG0811	peptide transport
H7R57_RS22620	COG0811	peptide transport
H7R57_RS22630	COG2771	luxR family
H7R57_RS22635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7R57_RS22640	COG1349	DNA-binding transcription factor activity
H7R57_RS22645	COG0745	RESPONSE REGULATOR receiver
H7R57_RS22650	COG2205	protein histidine kinase activity
H7R57_RS22665	COG4452	Inner membrane protein CreD
H7R57_RS22670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7R57_RS22675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7R57_RS22680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7R57_RS22685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7R57_RS22690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7R57_RS22695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7R57_RS22700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7R57_RS22710	COG0356	it plays a direct role in the translocation of protons across the membrane
H7R57_RS22720	COG1475	DNA binding
H7R57_RS22725	COG1192	Involved in chromosome partitioning
H7R57_RS22730	COG0357	Ribosomal RNA small subunit methyltransferase G
H7R57_RS22735	COG0445	tRNA wobble uridine modification
H7R57_RS22740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7R57_RS22745	COG3550	peptidyl-serine autophosphorylation
H7R57_RS22800	COG3385	transposase activity
H7R57_RS22820	COG4974	Belongs to the 'phage' integrase family
H7R57_RS22825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7R57_RS22830	COG0706	membrane insertase activity
H7R57_RS22835	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7R57_RS22840	COG0594	ribonuclease P activity
H7R57_RS22845	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7R57_RS22850	COG1126	abc transporter atp-binding protein
H7R57_RS22920	COG5433	transposase activity
H7R57_RS22925	COG0358	DNA primase activity
H7R57_RS22930	COG3041	Addiction module toxin RelE StbE family
H7R57_RS22935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R57_RS22950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R57_RS22965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R57_RS22980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R57_RS22985	COG3077	Addiction module antitoxin, RelB DinJ family
H7R57_RS23000	COG5433	transposase activity
H7R57_RS23030	COG2194	sulfuric ester hydrolase activity
H7R57_RS23065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7R57_RS23085	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
H7R57_RS23140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7R57_RS23175	COG3293	Transposase
H7R57_RS23185	COG1475	DNA binding
H7R57_RS23190	COG0556	nucleotide-excision repair
H7R57_RS23220	COG1702	phosphate starvation-inducible protein PhoH
H7R57_RS23230	COG4974	Belongs to the 'phage' integrase family
H7R57_RS23285	COG3041	Addiction module toxin RelE StbE family
H7R57_RS23290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R57_RS23300	COG1357	PFAM Pentapeptide repeats (8 copies)
H7R57_RS23335	COG1192	Involved in chromosome partitioning
H7R57_RS23475	COG2194	sulfuric ester hydrolase activity