locus-tag	class	description
H7R62_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7R62_RS00010	COG0592	DNA-directed DNA polymerase activity
H7R62_RS00020	COG0187	DNA topoisomerase II activity
H7R62_RS00030	COG2378	regulation of single-species biofilm formation
H7R62_RS00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7R62_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R62_RS00050	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R62_RS00055	COG3977	Valine--pyruvate aminotransferase
H7R62_RS00070	COG2814	Major facilitator Superfamily
H7R62_RS00075	COG0745	RESPONSE REGULATOR receiver
H7R62_RS00080	COG2205	protein histidine kinase activity
H7R62_RS00100	COG1733	regulation of RNA biosynthetic process
H7R62_RS00105	COG0604	alcohol dehydrogenase
H7R62_RS00115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R62_RS00120	COG4191	Histidine kinase
H7R62_RS00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R62_RS00125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R62_RS00130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R62_RS00135	COG1309	transcriptional regulator
H7R62_RS00165	COG0469	pyruvate kinase activity
H7R62_RS00170	COG2271	Major facilitator Superfamily
H7R62_RS00195	COG0561	phosphatase activity
H7R62_RS00200	COG2267	carboxylic ester hydrolase activity
H7R62_RS00205	COG0110	maltose O-acetyltransferase activity
H7R62_RS00210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R62_RS00215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R62_RS00220	COG1758	RNA polymerase activity
H7R62_RS00225	COG0194	GDP metabolic process
H7R62_RS00230	COG0859	PFAM glycosyl transferase family 9
H7R62_RS00235	COG3642	lipopolysaccharide core region biosynthetic process
H7R62_RS00275	COG0589	response to stress
H7R62_RS00280	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7R62_RS00285	COG1528	Iron-storage protein
H7R62_RS00290	COG2081	HI0933 family
H7R62_RS00295	COG3275	phosphorelay sensor kinase activity
H7R62_RS00300	COG3279	Response regulator of the LytR AlgR family
H7R62_RS00305	COG2223	nitrite transmembrane transporter activity
H7R62_RS00310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7R62_RS00315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7R62_RS00330	COG0583	DNA-binding transcription factor activity
H7R62_RS00375	COG3012	SEC-C Motif Domain Protein
H7R62_RS00375	COG3318	Belongs to the UPF0149 family
H7R62_RS00460	COG2003	Belongs to the UPF0758 family
H7R62_RS00510	COG3311	Transcriptional regulator
H7R62_RS00520	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R62_RS00545	COG0582	viral genome integration into host DNA
H7R62_RS00555	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R62_RS00555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R62_RS00555	COG1042	CoA-binding domain protein
H7R62_RS00575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7R62_RS00580	COG0166	Belongs to the GPI family
H7R62_RS00585	COG0668	transmembrane transport
H7R62_RS00590	COG1309	transcriptional regulator
H7R62_RS00595	COG0756	dUTP diphosphatase activity
H7R62_RS00600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7R62_RS00605	COG2003	Belongs to the UPF0758 family
H7R62_RS00610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7R62_RS00615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7R62_RS00625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7R62_RS00630	COG2990	Protein conserved in bacteria
H7R62_RS00635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7R62_RS00640	COG0859	PFAM glycosyl transferase family 9
H7R62_RS00645	COG0463	Glycosyl transferase, family 2
H7R62_RS00650	COG0859	PFAM glycosyl transferase family 9
H7R62_RS00655	COG1519	Transferase
H7R62_RS00670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R62_RS00675	COG1609	Transcriptional regulator
H7R62_RS00680	COG0604	alcohol dehydrogenase
H7R62_RS00700	COG3161	chorismate lyase activity
H7R62_RS00705	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7R62_RS00710	COG2937	Belongs to the GPAT DAPAT family
H7R62_RS00715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R62_RS00735	COG0534	Mate efflux family protein
H7R62_RS00740	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7R62_RS00745	COG2205	protein histidine kinase activity
H7R62_RS00750	COG0745	RESPONSE REGULATOR receiver
H7R62_RS00760	COG1045	serine acetyltransferase
H7R62_RS00770	COG3074	FtsZ-dependent cytokinesis
H7R62_RS00775	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H7R62_RS00780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R62_RS00780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R62_RS00785	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7R62_RS00825	COG1609	Transcriptional regulator
H7R62_RS00830	COG3250	beta-galactosidase activity
H7R62_RS00835	COG2731	YhcH YjgK YiaL family protein
H7R62_RS00840	COG0531	amino acid
H7R62_RS00845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R62_RS00850	COG0531	amino acid
H7R62_RS00855	COG0385	Bile acid
H7R62_RS00880	COG0583	DNA-binding transcription factor activity
H7R62_RS00885	COG2814	Major facilitator Superfamily
H7R62_RS00895	COG1538	Outer membrane efflux protein
H7R62_RS00900	COG1309	transcriptional regulator
H7R62_RS00905	COG1561	YicC-like family, N-terminal region
H7R62_RS00910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7R62_RS00915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7R62_RS00930	COG4251	negative regulation of phosphorylation
H7R62_RS00930	COG5001	Diguanylate cyclase
H7R62_RS00930	COG2203	Gaf domain
H7R62_RS00930	COG3706	GGDEF domain
H7R62_RS00935	COG3084	Protein conserved in bacteria
H7R62_RS00945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7R62_RS00950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R62_RS00960	COG1335	isochorismatase
H7R62_RS00970	COG1683	Conserved Protein
H7R62_RS00975	COG0204	Acyl-transferase
H7R62_RS00980	COG0204	Acyl-transferase
H7R62_RS00985	COG0606	chelatase, subunit chli
H7R62_RS00995	COG3978	acetolactate synthase activity
H7R62_RS01005	COG0129	dihydroxy-acid dehydratase activity
H7R62_RS01020	COG2391	methyltransferase activity
H7R62_RS01025	COG0840	transmembrane signaling receptor activity
H7R62_RS01030	COG2962	Rard protein
H7R62_RS01040	COG1012	belongs to the aldehyde dehydrogenase family
H7R62_RS01045	COG1396	sequence-specific DNA binding
H7R62_RS01050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7R62_RS01060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R62_RS01060	COG0519	Catalyzes the synthesis of GMP from XMP
H7R62_RS01065	COG0583	DNA-binding transcription factor activity
H7R62_RS01070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R62_RS01095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7R62_RS01100	COG2204	response regulator
H7R62_RS01115	COG0174	glutamine synthetase
H7R62_RS01120	COG1217	gtp-binding protein TYPA
H7R62_RS01125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R62_RS01130	COG0569	domain protein
H7R62_RS01135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R62_RS01135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R62_RS01140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7R62_RS01145	COG0242	peptide deformylase activity
H7R62_RS01150	COG1652	LysM domain
H7R62_RS01155	COG0758	DNA mediated transformation
H7R62_RS01160	COG2922	Belongs to the Smg family
H7R62_RS01165	COG0551	DNA topoisomerase type I activity
H7R62_RS01175	COG0009	L-threonylcarbamoyladenylate synthase
H7R62_RS01180	COG0408	coproporphyrinogen oxidase activity
H7R62_RS01185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7R62_RS01195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7R62_RS01205	COG3078	GTPase activator activity
H7R62_RS01215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7R62_RS01245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7R62_RS01250	COG1288	antiporter activity
H7R62_RS01255	COG1438	arginine binding
H7R62_RS01260	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H7R62_RS01265	COG0540	Belongs to the ATCase OTCase family
H7R62_RS01295	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H7R62_RS01320	COG3040	lipid binding
H7R62_RS01325	COG2207	Transcriptional regulator
H7R62_RS01330	COG1979	alcohol dehydrogenase
H7R62_RS01335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H7R62_RS01340	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H7R62_RS01345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R62_RS01350	COG2964	Protein conserved in bacteria
H7R62_RS01355	COG3681	Belongs to the UPF0597 family
H7R62_RS01365	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R62_RS01370	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R62_RS01375	COG0564	pseudouridine synthase activity
H7R62_RS01385	COG0542	response to heat
H7R62_RS01390	COG2502	aspartate--ammonia ligase
H7R62_RS01395	COG1522	sequence-specific DNA binding
H7R62_RS01405	COG5413	integral membrane protein
H7R62_RS01410	COG0516	GMP reductase activity
H7R62_RS01410	COG0517	IMP dehydrogenase activity
H7R62_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
H7R62_RS01430	COG2205	protein histidine kinase activity
H7R62_RS01440	COG2204	response regulator
H7R62_RS01455	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H7R62_RS01485	COG0243	molybdopterin cofactor binding
H7R62_RS01490	COG3005	denitrification pathway
H7R62_RS01495	COG4191	Histidine kinase
H7R62_RS01495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R62_RS01510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R62_RS01515	COG0569	domain protein
H7R62_RS01520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7R62_RS01545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R62_RS01560	COG0250	Participates in transcription elongation, termination and antitermination
H7R62_RS01565	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7R62_RS01570	COG0081	regulation of translation
H7R62_RS01575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7R62_RS01580	COG0222	ribosome binding
H7R62_RS01585	COG0085	RNA polymerase activity
H7R62_RS01590	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7R62_RS01595	COG2964	Protein conserved in bacteria
H7R62_RS01605	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R62_RS01610	COG2923	Belongs to the DsrF TusC family
H7R62_RS01615	COG2168	tRNA wobble position uridine thiolation
H7R62_RS01620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7R62_RS01625	COG0049	tRNA binding
H7R62_RS01630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7R62_RS01635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R62_RS01640	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R62_RS01675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R62_RS01675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R62_RS01690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7R62_RS01695	COG0038	chloride channel
H7R62_RS01705	COG0316	Belongs to the HesB IscA family
H7R62_RS01710	COG1757	Na H antiporter
H7R62_RS01750	COG0297	glycogen (starch) synthase activity
H7R62_RS01755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7R62_RS01760	COG2813	Specifically methylates the guanine in position
H7R62_RS01765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R62_RS01775	COG1392	Phosphate transport regulator
H7R62_RS01780	COG0306	phosphate transporter
H7R62_RS01785	COG0460	homoserine dehydrogenase
H7R62_RS01785	COG0527	aspartate kinase activity
H7R62_RS01790	COG0626	cystathionine gamma-synthase activity
H7R62_RS01800	COG0814	amino acid
H7R62_RS01805	COG1218	3'(2'),5'-bisphosphate nucleotidase
H7R62_RS01810	COG0494	nUDIX hydrolase
H7R62_RS01815	COG1011	Hydrolase
H7R62_RS01830	COG0110	maltose O-acetyltransferase activity
H7R62_RS01835	COG3174	membrane
H7R62_RS01840	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7R62_RS01850	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7R62_RS01855	COG4208	sulfate ABC transporter
H7R62_RS01860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7R62_RS01865	COG0583	DNA-binding transcription factor activity
H7R62_RS01875	COG0765	amino acid transport
H7R62_RS01885	COG1126	abc transporter atp-binding protein
H7R62_RS01890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R62_RS01895	COG3397	chitin binding
H7R62_RS01900	COG0840	transmembrane signaling receptor activity
H7R62_RS01915	COG1649	PFAM Uncharacterised BCR, COG1649
H7R62_RS01915	COG0726	polysaccharide deacetylase
H7R62_RS01920	COG1215	transferase activity, transferring glycosyl groups
H7R62_RS01950	COG1328	CTP reductase activity
H7R62_RS01955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R62_RS01970	COG1448	Aminotransferase
H7R62_RS01995	COG5433	transposase activity
H7R62_RS02020	COG0513	Belongs to the DEAD box helicase family
H7R62_RS02045	COG3112	Uncharacterised protein family (UPF0231)
H7R62_RS02050	COG3835	regulator
H7R62_RS02055	COG2610	gluconate transmembrane transporter activity
H7R62_RS02060	COG1929	Belongs to the glycerate kinase type-1 family
H7R62_RS02080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R62_RS02090	COG1872	DUF167
H7R62_RS02095	COG0762	integral membrane protein
H7R62_RS02100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7R62_RS02105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7R62_RS02120	COG3022	response to hydroperoxide
H7R62_RS02140	COG0347	Belongs to the P(II) protein family
H7R62_RS02145	COG1840	ABC-type Fe3 transport system, periplasmic component
H7R62_RS02155	COG3842	ATPase activity
H7R62_RS02160	COG2837	iron assimilation
H7R62_RS02165	COG1438	arginine binding
H7R62_RS02170	COG1126	abc transporter atp-binding protein
H7R62_RS02175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R62_RS02180	COG4215	(ABC) transporter
H7R62_RS02185	COG4160	amino acid transport
H7R62_RS02190	COG0039	L-malate dehydrogenase activity
H7R62_RS02195	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H7R62_RS02200	COG1017	nitric oxide dioxygenase activity
H7R62_RS02200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R62_RS02210	COG4536	flavin adenine dinucleotide binding
H7R62_RS02215	COG4137	Cytochrome C assembly protein
H7R62_RS02225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7R62_RS02230	COG0228	four-way junction DNA binding
H7R62_RS02235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7R62_RS02240	COG0336	Belongs to the RNA methyltransferase TrmD family
H7R62_RS02245	COG0335	large ribosomal subunit rRNA binding
H7R62_RS02255	COG3066	DNA modification
H7R62_RS02260	COG1051	belongs to the nudix hydrolase family
H7R62_RS02270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7R62_RS02275	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7R62_RS02280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R62_RS02290	COG0583	DNA-binding transcription factor activity
H7R62_RS02295	COG0640	Transcriptional regulator
H7R62_RS02300	COG0268	Binds directly to 16S ribosomal RNA
H7R62_RS02305	COG0728	peptidoglycan biosynthetic process
H7R62_RS02310	COG0196	riboflavin kinase activity
H7R62_RS02315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7R62_RS02320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7R62_RS02325	COG1047	Peptidyl-prolyl cis-trans
H7R62_RS02330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7R62_RS02360	COG5433	transposase activity
H7R62_RS02385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R62_RS02385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7R62_RS02400	COG1854	S-ribosylhomocysteine lyase activity
H7R62_RS02405	COG2165	general secretion pathway protein
H7R62_RS02410	COG0084	hydrolase, TatD family'
H7R62_RS02415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R62_RS02425	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7R62_RS02430	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7R62_RS02435	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H7R62_RS02445	COG5002	protein histidine kinase activity
H7R62_RS02445	COG5001	Diguanylate cyclase
H7R62_RS02445	COG3447	MASE1 domain protein
H7R62_RS02455	COG0560	Phosphoserine phosphatase
H7R62_RS02470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H7R62_RS02485	COG0776	regulation of translation
H7R62_RS02495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7R62_RS02500	COG1914	H( )-stimulated, divalent metal cation uptake system
H7R62_RS02505	COG0360	Binds together with S18 to 16S ribosomal RNA
H7R62_RS02510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7R62_RS02515	COG0359	binds to the 23S rRNA
H7R62_RS02520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R62_RS02540	COG1064	alcohol dehydrogenase
H7R62_RS02545	COG1238	metal cluster binding
H7R62_RS02550	COG0612	Peptidase, M16
H7R62_RS02555	COG2918	glutathione biosynthetic process
H7R62_RS02565	COG1022	Amp-dependent synthetase and ligase
H7R62_RS02575	COG0456	acetyltransferase
H7R62_RS02595	COG2199	diguanylate cyclase activity
H7R62_RS02600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H7R62_RS02620	COG0477	Major facilitator Superfamily
H7R62_RS02625	COG0583	DNA-binding transcription factor activity
H7R62_RS02630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R62_RS02635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R62_RS02645	COG0673	inositol 2-dehydrogenase activity
H7R62_RS02655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7R62_RS02660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7R62_RS02665	COG3036	rescue of stalled ribosome
H7R62_RS02675	COG0138	bifunctional purine biosynthesis protein purh
H7R62_RS02680	COG0151	Belongs to the GarS family
H7R62_RS02700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7R62_RS02705	COG0358	DNA primase activity
H7R62_RS02710	COG1610	YqeY-like protein
H7R62_RS02715	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7R62_RS02720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7R62_RS02725	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R62_RS02730	COG1027	Aspartate ammonia-lyase
H7R62_RS02735	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7R62_RS02740	COG0534	Mate efflux family protein
H7R62_RS02745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7R62_RS02750	COG0459	protein refolding
H7R62_RS02815	COG3714	YhhN family
H7R62_RS02840	COG1301	dicarboxylic acid transport
H7R62_RS02850	COG2095	MarC family integral membrane protein
H7R62_RS02860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R62_RS02870	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R62_RS02880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R62_RS02895	COG1770	oligopeptidase
H7R62_RS02910	COG4221	oxidoreductase activity
H7R62_RS02915	COG0583	DNA-binding transcription factor activity
H7R62_RS02920	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R62_RS02945	COG0742	ribosomal rna small subunit methyltransferase
H7R62_RS02950	COG0552	protein localization to endoplasmic reticulum
H7R62_RS02955	COG2884	Cell division ATP-binding protein ftsE
H7R62_RS02960	COG2177	Part of the ABC transporter FtsEX involved in
H7R62_RS02970	COG0288	reversible hydration of carbon dioxide
H7R62_RS02975	COG2188	Transcriptional regulator
H7R62_RS02980	COG1228	amidohydrolase
H7R62_RS02985	COG0010	Belongs to the arginase family
H7R62_RS02990	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7R62_RS02995	COG2986	histidine ammonia-lyase
H7R62_RS03000	COG0387	Pfam Sodium calcium exchanger
H7R62_RS03005	COG2200	EAL domain
H7R62_RS03010	COG2200	EAL domain
H7R62_RS03010	COG2199	diguanylate cyclase activity
H7R62_RS03055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R62_RS03060	COG1459	type II secretion system
H7R62_RS03080	COG4968	Prepilin-type N-terminal cleavage methylation domain
H7R62_RS03105	COG1077	Cell shape determining protein MreB Mrl
H7R62_RS03110	COG1792	Involved in formation and maintenance of cell shape
H7R62_RS03115	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7R62_RS03120	COG0424	maF-like protein
H7R62_RS03125	COG1530	ribonuclease E activity
H7R62_RS03130	COG3164	Protein of unknown function
H7R62_RS03140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R62_RS03145	COG0312	modulator of DNA gyrase
H7R62_RS03165	COG0477	Major facilitator Superfamily
H7R62_RS03210	COG0189	ligase activity
H7R62_RS03215	COG0642	Histidine kinase
H7R62_RS03220	COG0745	RESPONSE REGULATOR receiver
H7R62_RS03235	COG0789	Transcriptional regulator
H7R62_RS03240	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7R62_RS03245	COG0352	thiamine-phosphate diphosphorylase activity
H7R62_RS03250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R62_RS03260	COG2022	thiamine diphosphate biosynthetic process
H7R62_RS03265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R62_RS03270	COG5433	transposase activity
H7R62_RS03305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7R62_RS03325	COG0583	DNA-binding transcription factor activity
H7R62_RS03330	COG1380	Effector of murein hydrolase LrgA
H7R62_RS03335	COG1346	cytolysis
H7R62_RS03350	COG4667	esterase of the alpha-beta hydrolase superfamily
H7R62_RS03355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7R62_RS03360	COG0582	viral genome integration into host DNA
H7R62_RS03400	COG3706	GGDEF domain
H7R62_RS03410	COG0840	transmembrane signaling receptor activity
H7R62_RS03430	COG4467	Involved in initiation control of chromosome replication
H7R62_RS03540	COG2003	Belongs to the UPF0758 family
H7R62_RS03595	COG5377	YqaJ viral recombinase family
H7R62_RS03605	COG1546	Belongs to the CinA family
H7R62_RS03610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7R62_RS03620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7R62_RS03630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7R62_RS03665	COG1686	Belongs to the peptidase S11 family
H7R62_RS03670	COG0586	Pfam SNARE associated Golgi protein
H7R62_RS03675	COG1253	flavin adenine dinucleotide binding
H7R62_RS03680	COG0252	asparaginase activity
H7R62_RS03700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R62_RS03700	COG1263	PTS System
H7R62_RS03705	COG0366	Alpha amylase catalytic
H7R62_RS03710	COG0110	maltose O-acetyltransferase activity
H7R62_RS03720	COG0564	pseudouridine synthase activity
H7R62_RS03725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R62_RS03755	COG1484	DNA-dependent DNA replication
H7R62_RS03760	COG4584	PFAM Integrase catalytic
H7R62_RS03780	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7R62_RS03785	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H7R62_RS03790	COG1178	ABC-type Fe3 transport system permease component
H7R62_RS03810	COG0066	3-isopropylmalate dehydratase activity
H7R62_RS03815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7R62_RS03820	COG0473	3-isopropylmalate dehydrogenase activity
H7R62_RS03825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7R62_RS03850	COG0028	Belongs to the TPP enzyme family
H7R62_RS03855	COG0440	acetolactate synthase activity
H7R62_RS03860	COG3385	transposase activity
H7R62_RS03905	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7R62_RS03920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R62_RS03950	COG0745	RESPONSE REGULATOR receiver
H7R62_RS03955	COG3104	oligopeptide transport
H7R62_RS03960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7R62_RS03965	COG1555	photosystem II stabilization
H7R62_RS03970	COG0280	phosphate acetyltransferase
H7R62_RS03970	COG0857	belongs to the CobB CobQ family
H7R62_RS03975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R62_RS03985	COG3013	Belongs to the UPF0304 family
H7R62_RS03990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7R62_RS03995	COG2716	regulation of RNA biosynthetic process
H7R62_RS04000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R62_RS04005	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H7R62_RS04010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7R62_RS04045	COG0784	Response regulator, receiver
H7R62_RS04045	COG2198	Histidine kinase
H7R62_RS04045	COG5002	protein histidine kinase activity
H7R62_RS04060	COG2205	protein histidine kinase activity
H7R62_RS04060	COG0784	Response regulator, receiver
H7R62_RS04080	COG1464	Belongs to the NlpA lipoprotein family
H7R62_RS04085	COG2011	ABC-type metal ion transport system permease component
H7R62_RS04090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7R62_RS04110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7R62_RS04110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7R62_RS04115	COG0802	atpase or kinase
H7R62_RS04125	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7R62_RS04130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7R62_RS04135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7R62_RS04140	COG1923	regulation of RNA biosynthetic process
H7R62_RS04145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7R62_RS04150	COG0330	HflC and HflK could
H7R62_RS04155	COG0330	HflC and HflK could
H7R62_RS04160	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H7R62_RS04165	COG0142	geranyltranstransferase activity
H7R62_RS04170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7R62_RS04175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7R62_RS04180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7R62_RS04185	COG3314	Sporulation integral membrane protein YlbJ
H7R62_RS04190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7R62_RS04200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7R62_RS04205	COG2967	ApaG domain
H7R62_RS04210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7R62_RS04215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7R62_RS04220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R62_RS04225	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7R62_RS04230	COG3178	'Phosphotransferase
H7R62_RS04235	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7R62_RS04240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R62_RS04245	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R62_RS04250	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H7R62_RS04255	COG1073	alpha beta
H7R62_RS04270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7R62_RS04285	COG4628	conserved protein (DUF2132)
H7R62_RS04290	COG0688	phosphatidylethanolamine metabolic process
H7R62_RS04300	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7R62_RS04340	COG1278	Cold shock
H7R62_RS04350	COG0840	transmembrane signaling receptor activity
H7R62_RS04355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R62_RS04365	COG2252	PERMEase
H7R62_RS04375	COG0488	(ABC) transporter
H7R62_RS04390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7R62_RS04395	COG0741	lytic transglycosylase activity
H7R62_RS04420	COG4608	Belongs to the ABC transporter superfamily
H7R62_RS04425	COG0444	Belongs to the ABC transporter superfamily
H7R62_RS04435	COG4239	(ABC) transporter, permease
H7R62_RS04440	COG4174	ABC transporter (Permease)
H7R62_RS04445	COG4206	TonB-dependent receptor
H7R62_RS04455	COG0811	peptide transport
H7R62_RS04460	COG0811	peptide transport
H7R62_RS04465	COG0848	biopolymer transport protein
H7R62_RS04485	COG0616	signal peptide processing
H7R62_RS04490	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R62_RS04490	COG1902	pentaerythritol trinitrate reductase activity
H7R62_RS04495	COG0778	Nitroreductase
H7R62_RS04505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R62_RS04510	COG2264	protein methyltransferase activity
H7R62_RS04515	COG0604	alcohol dehydrogenase
H7R62_RS04520	COG0583	DNA-binding transcription factor activity
H7R62_RS04525	COG2190	(PTS) system
H7R62_RS04525	COG1263	PTS System
H7R62_RS04525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R62_RS04530	COG4145	pantothenate transmembrane transporter activity
H7R62_RS04540	COG0439	Biotin carboxylase
H7R62_RS04545	COG0511	ligase activity, forming carbon-carbon bonds
H7R62_RS04550	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7R62_RS04555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R62_RS04585	COG3381	protein complex oligomerization
H7R62_RS04595	COG3005	denitrification pathway
H7R62_RS04600	COG0745	RESPONSE REGULATOR receiver
H7R62_RS04610	COG1879	ABC-type sugar transport system periplasmic component
H7R62_RS04640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7R62_RS04645	COG3385	transposase activity
H7R62_RS04650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7R62_RS04655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R62_RS04655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R62_RS04670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7R62_RS04675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R62_RS04680	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7R62_RS04685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7R62_RS04700	COG0601	transmembrane transport
H7R62_RS04710	COG2900	Belongs to the SlyX family
H7R62_RS04720	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R62_RS04725	COG2204	response regulator
H7R62_RS04745	COG0737	Belongs to the 5'-nucleotidase family
H7R62_RS04785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7R62_RS04790	COG0142	geranyltranstransferase activity
H7R62_RS04795	COG1722	exodeoxyribonuclease VII activity
H7R62_RS04800	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R62_RS04805	COG1360	Flagellar Motor Protein
H7R62_RS04820	COG1534	Rna-binding protein
H7R62_RS04825	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7R62_RS04835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7R62_RS04840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7R62_RS04845	COG0149	triose-phosphate isomerase activity
H7R62_RS04850	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7R62_RS04865	COG0779	Required for maturation of 30S ribosomal subunits
H7R62_RS04870	COG0195	Participates in both transcription termination and antitermination
H7R62_RS04875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7R62_RS04880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7R62_RS04885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7R62_RS04890	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7R62_RS04895	COG1185	polyribonucleotide nucleotidyltransferase activity
H7R62_RS04900	COG2201	protein-glutamate methylesterase activity
H7R62_RS04905	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H7R62_RS04915	COG0840	transmembrane signaling receptor activity
H7R62_RS04920	COG0835	chemotaxis
H7R62_RS04930	COG2198	Histidine kinase
H7R62_RS04930	COG0643	Histidine kinase
H7R62_RS04940	COG0745	RESPONSE REGULATOR receiver
H7R62_RS04950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R62_RS04955	COG0583	DNA-binding transcription factor activity
H7R62_RS04960	COG1280	lysine exporter protein (LysE YggA)
H7R62_RS04965	COG0826	peptidase U32
H7R62_RS04970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R62_RS04980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R62_RS04990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R62_RS04995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7R62_RS05035	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H7R62_RS05060	COG0300	oxidoreductase activity
H7R62_RS05180	COG2003	Belongs to the UPF0758 family
H7R62_RS05225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R62_RS05250	COG1879	ABC-type sugar transport system periplasmic component
H7R62_RS05260	COG3041	Addiction module toxin RelE StbE family
H7R62_RS05265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R62_RS05275	COG5377	YqaJ viral recombinase family
H7R62_RS05305	COG0077	Prephenate dehydratase
H7R62_RS05305	COG1605	Chorismate mutase
H7R62_RS05340	COG3272	Protein of unknown function (DUF1722)
H7R62_RS05345	COG0789	Transcriptional regulator
H7R62_RS05350	COG0415	Belongs to the DNA photolyase family
H7R62_RS05360	COG0300	oxidoreductase activity
H7R62_RS05375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7R62_RS05405	COG1477	protein flavinylation
H7R62_RS05410	COG2871	sodium ion transport
H7R62_RS05415	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R62_RS05420	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R62_RS05425	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R62_RS05430	COG1805	sodium ion transport
H7R62_RS05435	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R62_RS05440	COG0271	Belongs to the BolA IbaG family
H7R62_RS05445	COG2813	Specifically methylates the guanine in position
H7R62_RS05455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R62_RS05460	COG2211	Major facilitator Superfamily
H7R62_RS05465	COG3248	Nucleoside-binding outer membrane protein
H7R62_RS05470	COG1666	GTP binding
H7R62_RS05475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7R62_RS05480	COG0693	protein deglycase activity
H7R62_RS05490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7R62_RS05495	COG0840	transmembrane signaling receptor activity
H7R62_RS05500	COG0583	DNA-binding transcription factor activity
H7R62_RS05510	COG2363	Small membrane protein
H7R62_RS05515	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H7R62_RS05525	COG0473	3-isopropylmalate dehydrogenase activity
H7R62_RS05530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R62_RS05535	COG1611	Belongs to the LOG family
H7R62_RS05550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R62_RS05550	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R62_RS05560	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H7R62_RS05585	COG3098	single-species biofilm formation
H7R62_RS05590	COG0564	pseudouridine synthase activity
H7R62_RS05610	COG1263	PTS System
H7R62_RS05610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R62_RS05620	COG2171	N-acyltransferase activity
H7R62_RS05630	COG0024	Methionine aminopeptidase
H7R62_RS05635	COG0052	Belongs to the universal ribosomal protein uS2 family
H7R62_RS05640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7R62_RS05645	COG0528	UMP kinase activity
H7R62_RS05650	COG0233	cytoplasmic translational termination
H7R62_RS05655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7R62_RS05660	COG0575	Belongs to the CDS family
H7R62_RS05665	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7R62_RS05670	COG0750	zinc metalloprotease
H7R62_RS05685	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R62_RS05690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R62_RS05695	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R62_RS05700	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R62_RS05705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7R62_RS05715	COG0825	malonyl-CoA metabolic process
H7R62_RS05725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R62_RS05730	COG1115	amino acid carrier protein
H7R62_RS05745	COG0714	Associated with various cellular activities
H7R62_RS05805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7R62_RS05810	COG1678	Uncharacterized ACR, COG1678
H7R62_RS05820	COG0189	ligase activity
H7R62_RS05825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7R62_RS05835	COG3091	SprT-like family
H7R62_RS05845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7R62_RS05855	COG0251	oxidation-reduction process
H7R62_RS05860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7R62_RS05865	COG0739	heme binding
H7R62_RS05870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R62_RS05885	COG0814	amino acid
H7R62_RS05900	COG0531	amino acid
H7R62_RS05910	COG0488	(ABC) transporter
H7R62_RS05915	COG3710	Transcriptional regulator
H7R62_RS05920	COG0531	amino acid
H7R62_RS05925	COG1982	Orn Lys Arg decarboxylase major
H7R62_RS05930	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7R62_RS05945	COG3590	peptidase
H7R62_RS05955	COG2203	Gaf domain
H7R62_RS05955	COG2199	diguanylate cyclase activity
H7R62_RS05990	COG0366	Alpha amylase catalytic
H7R62_RS06005	COG0463	Glycosyl transferase, family 2
H7R62_RS06020	COG2989	Protein conserved in bacteria
H7R62_RS06025	COG3108	Peptidase M15
H7R62_RS06035	COG2860	membrane
H7R62_RS06045	COG1196	nuclear chromosome segregation
H7R62_RS06050	COG3115	cell septum assembly
H7R62_RS06055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7R62_RS06070	COG0602	queuosine metabolic process
H7R62_RS06105	COG1846	Transcriptional regulator
H7R62_RS06115	COG0281	malic enzyme
H7R62_RS06120	COG3290	protein histidine kinase activity
H7R62_RS06130	COG0697	spore germination
H7R62_RS06135	COG3385	transposase activity
H7R62_RS06145	COG0346	lactoylglutathione lyase activity
H7R62_RS06150	COG0745	RESPONSE REGULATOR receiver
H7R62_RS06155	COG5002	protein histidine kinase activity
H7R62_RS06180	COG3142	Participates in the control of copper homeostasis
H7R62_RS06185	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R62_RS06210	COG0678	peroxiredoxin activity
H7R62_RS06220	COG0019	diaminopimelate decarboxylase activity
H7R62_RS06225	COG1115	amino acid carrier protein
H7R62_RS06230	COG0095	Lipoate-protein ligase
H7R62_RS06235	COG2233	PERMEase
H7R62_RS06250	COG0534	Mate efflux family protein
H7R62_RS06260	COG0281	malic enzyme
H7R62_RS06290	COG0733	neurotransmitter:sodium symporter activity
H7R62_RS06295	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R62_RS06300	COG3706	GGDEF domain
H7R62_RS06305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R62_RS06315	COG1032	radical SAM domain protein
H7R62_RS06340	COG0673	inositol 2-dehydrogenase activity
H7R62_RS06345	COG2920	part of a sulfur-relay system
H7R62_RS06350	COG1289	transmembrane transporter activity
H7R62_RS06355	COG0670	Belongs to the BI1 family
H7R62_RS06375	COG1486	melibiose metabolic process
H7R62_RS06380	COG1917	Cupin 2, conserved barrel domain protein
H7R62_RS06380	COG2169	Transcriptional regulator
H7R62_RS06385	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7R62_RS06390	COG2723	6-phospho-beta-galactosidase activity
H7R62_RS06395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7R62_RS06400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7R62_RS06410	COG1446	asparaginase
H7R62_RS06415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R62_RS06420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7R62_RS06425	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7R62_RS06440	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H7R62_RS06450	COG3156	type II secretion system protein K
H7R62_RS06455	COG4795	General secretion pathway protein
H7R62_RS06460	COG2165	general secretion pathway protein
H7R62_RS06470	COG2165	general secretion pathway protein
H7R62_RS06475	COG1459	type II secretion system
H7R62_RS06480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R62_RS06500	COG3409	Peptidoglycan-binding domain 1 protein
H7R62_RS06500	COG3267	Type II secretory pathway component ExeA
H7R62_RS06505	COG2770	Histidine kinase
H7R62_RS06505	COG3437	response regulator, receiver
H7R62_RS06520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7R62_RS06525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7R62_RS06530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R62_RS06540	COG2190	(PTS) system
H7R62_RS06550	COG3264	Mechanosensitive ion channel
H7R62_RS06550	COG1196	nuclear chromosome segregation
H7R62_RS06555	COG0469	pyruvate kinase activity
H7R62_RS06565	COG3384	dioxygenase
H7R62_RS06570	COG0419	ATPase involved in DNA repair
H7R62_RS06575	COG0420	3'-5' exonuclease activity
H7R62_RS06585	COG2974	May be involved in recombination
H7R62_RS06605	COG0531	amino acid
H7R62_RS06610	COG0531	amino acid
H7R62_RS06625	COG1917	Cupin 2, conserved barrel domain protein
H7R62_RS06625	COG1396	sequence-specific DNA binding
H7R62_RS06630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R62_RS06695	COG3038	cytochrome b561
H7R62_RS06700	COG1720	tRNA m6t6A37 methyltransferase activity
H7R62_RS06720	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7R62_RS06725	COG4988	ABC transporter
H7R62_RS06740	COG0745	RESPONSE REGULATOR receiver
H7R62_RS06750	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R62_RS06785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R62_RS06790	COG3385	transposase activity
H7R62_RS06795	COG3550	peptidyl-serine autophosphorylation
H7R62_RS06800	COG1396	sequence-specific DNA binding
H7R62_RS06805	COG1988	membrane-bound metal-dependent
H7R62_RS06830	COG0159	tryptophan synthase activity
H7R62_RS06835	COG0133	tryptophan synthase activity
H7R62_RS06840	COG0135	phosphoribosylanthranilate isomerase activity
H7R62_RS06840	COG0134	indole-3-glycerol-phosphate synthase activity
H7R62_RS06845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R62_RS06850	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R62_RS06850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R62_RS06855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7R62_RS06865	COG0009	L-threonylcarbamoyladenylate synthase
H7R62_RS06875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7R62_RS06885	COG1946	Acyl-CoA thioesterase
H7R62_RS06890	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H7R62_RS06895	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7R62_RS06905	COG0083	homoserine kinase activity
H7R62_RS06910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7R62_RS06920	COG1484	DNA-dependent DNA replication
H7R62_RS06925	COG4584	PFAM Integrase catalytic
H7R62_RS06935	COG1943	Transposase
H7R62_RS06940	COG1484	DNA-dependent DNA replication
H7R62_RS06945	COG4584	PFAM Integrase catalytic
H7R62_RS06955	COG0675	Transposase, IS605 OrfB family
H7R62_RS06970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R62_RS06990	COG1342	Belongs to the UPF0251 family
H7R62_RS07005	COG1309	transcriptional regulator
H7R62_RS07010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R62_RS07015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R62_RS07030	COG0686	Belongs to the AlaDH PNT family
H7R62_RS07050	COG0438	transferase activity, transferring glycosyl groups
H7R62_RS07075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7R62_RS07090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7R62_RS07105	COG3206	protein involved in exopolysaccharide biosynthesis
H7R62_RS07105	COG0489	protein tyrosine kinase activity
H7R62_RS07125	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R62_RS07150	COG1136	(ABC) transporter
H7R62_RS07150	COG0577	efflux transmembrane transporter activity
H7R62_RS07155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R62_RS07170	COG0675	Transposase, IS605 OrfB family
H7R62_RS07175	COG1227	inorganic diphosphatase activity
H7R62_RS07185	COG0497	DNA recombination
H7R62_RS07190	COG1486	melibiose metabolic process
H7R62_RS07200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7R62_RS07205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7R62_RS07210	COG0443	Heat shock 70 kDa protein
H7R62_RS07215	COG0484	heat shock protein binding
H7R62_RS07250	COG1285	pathogenesis
H7R62_RS07290	COG1566	PFAM secretion protein HlyD family protein
H7R62_RS07295	COG0577	efflux transmembrane transporter activity
H7R62_RS07295	COG1136	(ABC) transporter
H7R62_RS07300	COG0577	efflux transmembrane transporter activity
H7R62_RS07300	COG1136	(ABC) transporter
H7R62_RS07305	COG0577	efflux transmembrane transporter activity
H7R62_RS07305	COG1136	(ABC) transporter
H7R62_RS07315	COG0095	Lipoate-protein ligase
H7R62_RS07325	COG0702	epimerase
H7R62_RS07330	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R62_RS07335	COG1454	alcohol dehydrogenase
H7R62_RS07345	COG0564	pseudouridine synthase activity
H7R62_RS07375	COG1280	lysine exporter protein (LysE YggA)
H7R62_RS07390	COG3263	regulation of cellular component size
H7R62_RS07400	COG1876	peptidase activity
H7R62_RS07405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7R62_RS07410	COG1393	Belongs to the ArsC family
H7R62_RS07420	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R62_RS07425	COG1473	amidohydrolase
H7R62_RS07435	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R62_RS07445	COG0017	Asparaginyl-tRNA synthetase
H7R62_RS07460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7R62_RS07465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R62_RS07470	COG0156	8-amino-7-oxononanoate synthase activity
H7R62_RS07475	COG2226	methyltransferase
H7R62_RS07475	COG1073	alpha beta
H7R62_RS07480	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7R62_RS07485	COG0501	Belongs to the peptidase M48B family
H7R62_RS07495	COG0633	Ferredoxin
H7R62_RS07495	COG3217	Mosc domain protein beta barrel domain protein
H7R62_RS07495	COG3217	Mosc domain protein beta barrel domain protein
H7R62_RS07495	COG0633	Ferredoxin
H7R62_RS07510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7R62_RS07510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7R62_RS07510	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7R62_RS07510	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7R62_RS07520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R62_RS07525	COG1607	acyl-coa hydrolase
H7R62_RS07535	COG3021	interspecies interaction between organisms
H7R62_RS07540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7R62_RS07545	COG2027	D-alanyl-D-alanine carboxypeptidase
H7R62_RS07550	COG1061	Type III restriction enzyme res subunit
H7R62_RS07555	COG1566	PFAM secretion protein HlyD family protein
H7R62_RS07565	COG1966	Carbon starvation protein
H7R62_RS07570	COG3279	Response regulator of the LytR AlgR family
H7R62_RS07575	COG3275	phosphorelay sensor kinase activity
H7R62_RS07580	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R62_RS07580	COG2199	diguanylate cyclase activity
H7R62_RS07585	COG2194	sulfuric ester hydrolase activity
H7R62_RS07590	COG1846	Transcriptional regulator
H7R62_RS07590	COG1940	carbohydrate kinase activity
H7R62_RS07595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R62_RS07600	COG0363	glucosamine-6-phosphate deaminase activity
H7R62_RS07605	COG1263	PTS System
H7R62_RS07605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R62_RS07605	COG2190	(PTS) system
H7R62_RS07615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R62_RS07620	COG0735	belongs to the Fur family
H7R62_RS07630	COG0716	FMN binding
H7R62_RS07645	COG0596	Alpha beta hydrolase
H7R62_RS07650	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H7R62_RS07655	COG0033	Phosphoglucomutase
H7R62_RS07660	COG2951	lytic endotransglycosylase activity
H7R62_RS07665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7R62_RS07670	COG4136	ATPase activity
H7R62_RS07675	COG4135	transport system, permease component
H7R62_RS07680	COG4134	Bacterial extracellular solute-binding protein
H7R62_RS07690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7R62_RS07700	COG0675	Transposase, IS605 OrfB family
H7R62_RS07710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R62_RS07720	COG0729	surface antigen
H7R62_RS07725	COG2911	Protein conserved in bacteria
H7R62_RS07740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7R62_RS07750	COG0741	lytic transglycosylase activity
H7R62_RS07785	COG1278	Cold shock
H7R62_RS07810	COG0697	spore germination
H7R62_RS07815	COG1349	DNA-binding transcription factor activity
H7R62_RS07820	COG1882	Formate acetyltransferase
H7R62_RS07825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R62_RS07830	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R62_RS07845	COG1187	pseudouridine synthase activity
H7R62_RS07855	COG4166	transmembrane transport
H7R62_RS07860	COG0622	Phosphoesterase
H7R62_RS07875	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H7R62_RS07880	COG0784	Response regulator, receiver
H7R62_RS07880	COG0835	chemotaxis
H7R62_RS07885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7R62_RS07890	COG1815	bacterial-type flagellum-dependent cell motility
H7R62_RS07900	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7R62_RS07910	COG4787	bacterial-type flagellum-dependent cell motility
H7R62_RS07920	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7R62_RS07925	COG1706	bacterial-type flagellum-dependent cell motility
H7R62_RS07940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7R62_RS07945	COG2239	Acts as a magnesium transporter
H7R62_RS07955	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7R62_RS07960	COG2716	regulation of RNA biosynthetic process
H7R62_RS07985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7R62_RS07990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7R62_RS07995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7R62_RS08000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7R62_RS08020	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7R62_RS08035	COG0590	tRNA wobble adenosine to inosine editing
H7R62_RS08040	COG0573	inorganic phosphate transmembrane transporter activity
H7R62_RS08045	COG0581	inorganic phosphate transmembrane transporter activity
H7R62_RS08050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7R62_RS08055	COG0704	Plays a role in the regulation of phosphate uptake
H7R62_RS08060	COG1253	flavin adenine dinucleotide binding
H7R62_RS08070	COG1410	methionine synthase
H7R62_RS08070	COG0646	methionine synthase
H7R62_RS08075	COG0531	amino acid
H7R62_RS08090	COG1126	abc transporter atp-binding protein
H7R62_RS08095	COG0765	amino acid transport
H7R62_RS08100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R62_RS08105	COG3706	GGDEF domain
H7R62_RS08110	COG2271	Major facilitator Superfamily
H7R62_RS08120	COG2197	response regulator
H7R62_RS08125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R62_RS08145	COG1785	Belongs to the alkaline phosphatase family
H7R62_RS08150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7R62_RS08155	COG3385	transposase activity
H7R62_RS08160	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7R62_RS08170	COG1199	ATP-dependent helicase activity
H7R62_RS08180	COG1605	Chorismate mutase
H7R62_RS08180	COG0287	Prephenate dehydrogenase
H7R62_RS08185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R62_RS08195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R62_RS08200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R62_RS08235	COG0537	adenosine 5'-monophosphoramidase activity
H7R62_RS08250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7R62_RS08265	COG1301	dicarboxylic acid transport
H7R62_RS08280	COG2354	Protein conserved in bacteria
H7R62_RS08290	COG2233	PERMEase
H7R62_RS08295	COG3150	esterase
H7R62_RS08300	COG1252	NADH dehydrogenase
H7R62_RS08310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R62_RS08315	COG5001	Diguanylate cyclase
H7R62_RS08315	COG3300	MHYT domain
H7R62_RS08320	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R62_RS08330	COG2373	Large extracellular alpha-helical protein
H7R62_RS08335	COG4953	penicillin-binding protein 1C
H7R62_RS08350	COG0301	tRNA thio-modification
H7R62_RS08350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R62_RS08355	COG3385	transposase activity
H7R62_RS08450	COG1083	cytidylyl-transferase
H7R62_RS08480	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R62_RS08490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R62_RS08505	COG1106	Psort location Cytoplasmic, score
H7R62_RS08550	COG3385	transposase activity
H7R62_RS08555	COG2119	membrane
H7R62_RS08560	COG0023	Translation Initiation Factor
H7R62_RS08585	COG0513	Belongs to the DEAD box helicase family
H7R62_RS08600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R62_RS08605	COG0765	amino acid transport
H7R62_RS08610	COG1126	abc transporter atp-binding protein
H7R62_RS08615	COG0493	'glutamate synthase
H7R62_RS08620	COG0070	glutamate synthase
H7R62_RS08620	COG0067	glutamate synthase
H7R62_RS08620	COG0069	glutamate synthase activity
H7R62_RS08625	COG1242	4 iron, 4 sulfur cluster binding
H7R62_RS08660	COG4584	PFAM Integrase catalytic
H7R62_RS08665	COG1484	DNA-dependent DNA replication
H7R62_RS08695	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7R62_RS08705	COG4804	nuclease activity
H7R62_RS08715	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7R62_RS08720	COG3634	alkyl hydroperoxide reductase activity
H7R62_RS08730	COG0517	IMP dehydrogenase activity
H7R62_RS08735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7R62_RS08740	COG0343	queuine tRNA-ribosyltransferase activity
H7R62_RS08745	COG1862	Preprotein translocase
H7R62_RS08750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R62_RS08755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R62_RS08760	COG2897	thiosulfate sulfurtransferase activity
H7R62_RS08770	COG0826	peptidase U32
H7R62_RS08775	COG0826	peptidase U32
H7R62_RS08780	COG3154	lipid carrier protein
H7R62_RS08800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7R62_RS08805	COG0574	Belongs to the PEP-utilizing enzyme family
H7R62_RS08805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7R62_RS08820	COG1464	Belongs to the NlpA lipoprotein family
H7R62_RS08825	COG3083	sulfuric ester hydrolase activity
H7R62_RS08830	COG3082	Protein of unknown function (DUF1414)
H7R62_RS08835	COG3081	Nucleoid-associated protein
H7R62_RS08845	COG1175	transmembrane transport
H7R62_RS08850	COG3833	ABC-type maltose transport systems, permease component
H7R62_RS08855	COG3842	ATPase activity
H7R62_RS08880	COG0425	Belongs to the sulfur carrier protein TusA family
H7R62_RS08885	COG4783	chaperone-mediated protein folding
H7R62_RS08895	COG1393	Belongs to the ArsC family
H7R62_RS08915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R62_RS08920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R62_RS08925	COG2431	L-lysine efflux transmembrane transporter activity
H7R62_RS08935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R62_RS08945	COG4160	amino acid transport
H7R62_RS08950	COG0564	pseudouridine synthase activity
H7R62_RS08965	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7R62_RS08975	COG0625	glutathione transferase activity
H7R62_RS08985	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R62_RS08990	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R62_RS08995	COG0367	asparagine synthase
H7R62_RS09005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7R62_RS09005	COG4651	solute:proton antiporter activity
H7R62_RS09010	COG0647	UMP catabolic process
H7R62_RS09025	COG1902	pentaerythritol trinitrate reductase activity
H7R62_RS09030	COG1253	flavin adenine dinucleotide binding
H7R62_RS09040	COG0277	FAD linked oxidase domain protein
H7R62_RS09040	COG0247	lactate metabolic process
H7R62_RS09050	COG2050	protein possibly involved in aromatic compounds catabolism
H7R62_RS09055	COG0513	Belongs to the DEAD box helicase family
H7R62_RS09060	COG2056	Na+-H+ antiporter family
H7R62_RS09065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R62_RS09070	COG0671	phosphoesterase, PA-phosphatase related
H7R62_RS09075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R62_RS09080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R62_RS09090	COG0101	tRNA pseudouridine synthase activity
H7R62_RS09095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7R62_RS09100	COG0285	dihydrofolate synthase activity
H7R62_RS09105	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H7R62_RS09110	COG0393	Putative heavy-metal-binding
H7R62_RS09120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R62_RS09120	COG1648	precorrin-2 dehydrogenase activity
H7R62_RS09140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R62_RS09160	COG4667	esterase of the alpha-beta hydrolase superfamily
H7R62_RS09165	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7R62_RS09170	COG1368	sulfuric ester hydrolase activity
H7R62_RS09185	COG2814	Major facilitator Superfamily
H7R62_RS09200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R62_RS09205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7R62_RS09210	COG0539	negative regulation of cytoplasmic translation
H7R62_RS09215	COG0776	regulation of translation
H7R62_RS09225	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7R62_RS09245	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7R62_RS09250	COG0602	queuosine metabolic process
H7R62_RS09255	COG3530	Putative quorum-sensing-regulated virulence factor
H7R62_RS09260	COG2096	Adenosyltransferase
H7R62_RS09265	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R62_RS09270	COG1757	Na H antiporter
H7R62_RS09275	COG1435	thymidine kinase activity
H7R62_RS09295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7R62_RS09300	COG0326	Molecular chaperone. Has ATPase activity
H7R62_RS09305	COG4172	Belongs to the ABC transporter superfamily
H7R62_RS09310	COG4172	Belongs to the ABC transporter superfamily
H7R62_RS09320	COG4168	peptide transport system, permease
H7R62_RS09325	COG0747	negative chemotaxis
H7R62_RS09330	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7R62_RS09335	COG1842	Phage shock protein A
H7R62_RS09350	COG3106	COG3106 Predicted ATPase
H7R62_RS09355	COG3768	UPF0283 membrane protein
H7R62_RS09360	COG0583	DNA-binding transcription factor activity
H7R62_RS09365	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7R62_RS09370	COG3842	ATPase activity
H7R62_RS09375	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R62_RS09380	COG1177	transmembrane transport
H7R62_RS09385	COG1012	belongs to the aldehyde dehydrogenase family
H7R62_RS09395	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7R62_RS09415	COG2199	diguanylate cyclase activity
H7R62_RS09420	COG2885	chlorophyll binding
H7R62_RS09425	COG0861	Integral membrane protein TerC family
H7R62_RS09440	COG1022	Amp-dependent synthetase and ligase
H7R62_RS09455	COG2910	NAD(P)H-binding
H7R62_RS09460	COG0583	DNA-binding transcription factor activity
H7R62_RS09465	COG0583	DNA-binding transcription factor activity
H7R62_RS09470	COG0583	DNA-binding transcription factor activity
H7R62_RS09475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7R62_RS09485	COG0583	DNA-binding transcription factor activity
H7R62_RS09490	COG2723	6-phospho-beta-galactosidase activity
H7R62_RS09495	COG1944	ATP diphosphatase activity
H7R62_RS09500	COG2116	formate transmembrane transporter activity
H7R62_RS09505	COG1882	Formate acetyltransferase
H7R62_RS09510	COG2983	Belongs to the UPF0260 family
H7R62_RS09515	COG4166	transmembrane transport
H7R62_RS09520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7R62_RS09525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7R62_RS09535	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R62_RS09540	COG1136	(ABC) transporter
H7R62_RS09545	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R62_RS09550	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H7R62_RS09560	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7R62_RS09565	COG0740	serine-type endopeptidase activity
H7R62_RS09570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7R62_RS09575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7R62_RS09580	COG0776	regulation of translation
H7R62_RS09585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R62_RS09590	COG0488	(ABC) transporter
H7R62_RS09595	COG0582	viral genome integration into host DNA
H7R62_RS09615	COG2974	May be involved in recombination
H7R62_RS09655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R62_RS09725	COG0270	DNA (cytosine-5-)-methyltransferase activity
H7R62_RS09935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R62_RS09940	COG3162	membrane
H7R62_RS09955	COG1024	Enoyl-CoA hydratase
H7R62_RS09960	COG1115	amino acid carrier protein
H7R62_RS09975	COG1584	GPR1 FUN34 yaaH family protein
H7R62_RS10005	COG1024	Enoyl-CoA hydratase
H7R62_RS10010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7R62_RS10015	COG1960	acyl-CoA dehydrogenase activity
H7R62_RS10020	COG1960	acyl-CoA dehydrogenase activity
H7R62_RS10025	COG1024	Enoyl-CoA hydratase
H7R62_RS10030	COG1024	Enoyl-CoA hydratase
H7R62_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
H7R62_RS10050	COG0730	response to heat
H7R62_RS10070	COG0640	Transcriptional regulator
H7R62_RS10085	COG0798	PFAM Bile acid sodium symporter
H7R62_RS10090	COG1393	Belongs to the ArsC family
H7R62_RS10125	COG1993	acr, cog1993
H7R62_RS10130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7R62_RS10150	COG2203	Gaf domain
H7R62_RS10150	COG4251	negative regulation of phosphorylation
H7R62_RS10150	COG3706	GGDEF domain
H7R62_RS10150	COG5001	Diguanylate cyclase
H7R62_RS10155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R62_RS10160	COG3437	response regulator, receiver
H7R62_RS10175	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H7R62_RS10180	COG0437	4 iron, 4 sulfur cluster binding
H7R62_RS10185	COG5557	Pfam Polysulphide reductase, NrfD
H7R62_RS10190	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H7R62_RS10195	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7R62_RS10200	COG1773	rubredoxin
H7R62_RS10210	COG0601	transmembrane transport
H7R62_RS10215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R62_RS10225	COG3842	ATPase activity
H7R62_RS10230	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H7R62_RS10235	COG0375	protein maturation
H7R62_RS10240	COG0309	Hydrogenase expression formation protein (HypE)
H7R62_RS10250	COG0298	carbon dioxide binding
H7R62_RS10255	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7R62_RS10265	COG1921	L-seryl-tRNASec selenium transferase activity
H7R62_RS10270	COG3385	transposase activity
H7R62_RS10280	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7R62_RS10290	COG3260	NADH ubiquinone oxidoreductase 20
H7R62_RS10295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R62_RS10300	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H7R62_RS10300	COG3261	NADH dehydrogenase
H7R62_RS10305	COG0650	Formate hydrogenlyase subunit 4
H7R62_RS10310	COG0651	ATP synthesis coupled electron transport
H7R62_RS10315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R62_RS10335	COG0583	DNA-binding transcription factor activity
H7R62_RS10345	COG1560	Kdo2-lipid A biosynthetic process
H7R62_RS10350	COG1560	Kdo2-lipid A biosynthetic process
H7R62_RS10365	COG2199	diguanylate cyclase activity
H7R62_RS10365	COG2203	Gaf domain
H7R62_RS10375	COG0417	DNA replication proofreading
H7R62_RS10390	COG1451	nucleotide metabolic process
H7R62_RS10405	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R62_RS10420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R62_RS10420	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7R62_RS10425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7R62_RS10430	COG0569	domain protein
H7R62_RS10430	COG2985	domain, Protein
H7R62_RS10440	COG0556	nucleotide-excision repair
H7R62_RS10450	COG0586	Pfam SNARE associated Golgi protein
H7R62_RS10455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7R62_RS10460	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R62_RS10475	COG4681	YaeQ
H7R62_RS10485	COG3829	transcription factor binding
H7R62_RS10525	COG0307	riboflavin synthase, alpha
H7R62_RS10530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R62_RS10535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R62_RS10550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R62_RS10555	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H7R62_RS10560	COG0697	spore germination
H7R62_RS10565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7R62_RS10605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R62_RS10610	COG3099	Belongs to the UPF0263 family
H7R62_RS10615	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7R62_RS10620	COG2894	cell division
H7R62_RS10625	COG0850	regulation of cytokinetic process
H7R62_RS10630	COG3100	YcgL domain-containing protein
H7R62_RS10635	COG1760	l-serine dehydratase
H7R62_RS10640	COG1760	l-serine dehydratase
H7R62_RS10645	COG3123	guanosine phosphorylase activity
H7R62_RS10660	COG0205	6-phosphofructokinase activity
H7R62_RS10670	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H7R62_RS10675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R62_RS10685	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H7R62_RS10690	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7R62_RS10695	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7R62_RS10740	COG0641	radical SAM
H7R62_RS10750	COG5433	transposase activity
H7R62_RS10755	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R62_RS10765	COG5433	transposase activity
H7R62_RS10790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7R62_RS10795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7R62_RS10800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7R62_RS10810	COG0549	Belongs to the carbamate kinase family
H7R62_RS10815	COG0697	spore germination
H7R62_RS10825	COG3608	succinylglutamate desuccinylase aspartoacylase
H7R62_RS10825	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7R62_RS10830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7R62_RS10835	COG2068	MobA-Related Protein
H7R62_RS10840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R62_RS10840	COG0493	'glutamate synthase
H7R62_RS10845	COG0402	S-adenosylhomocysteine deaminase activity
H7R62_RS10850	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7R62_RS10855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7R62_RS10855	COG2080	2 iron, 2 sulfur cluster binding
H7R62_RS10860	COG2233	PERMEase
H7R62_RS10865	COG0402	S-adenosylhomocysteine deaminase activity
H7R62_RS10870	COG2252	PERMEase
H7R62_RS10880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7R62_RS10885	COG2080	2 iron, 2 sulfur cluster binding
H7R62_RS10890	COG3134	Outer membrane lipoprotein
H7R62_RS10900	COG1288	antiporter activity
H7R62_RS10905	COG0318	PFAM AMP-dependent synthetase and ligase
H7R62_RS10910	COG2199	diguanylate cyclase activity
H7R62_RS10925	COG0107	imidazoleglycerol-phosphate synthase activity
H7R62_RS10930	COG2205	protein histidine kinase activity
H7R62_RS10930	COG0784	Response regulator, receiver
H7R62_RS10930	COG2198	Histidine kinase
H7R62_RS10935	COG2199	diguanylate cyclase activity
H7R62_RS10940	COG3437	response regulator, receiver
H7R62_RS10945	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7R62_RS10950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7R62_RS10955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R62_RS10955	COG0131	Imidazoleglycerol-phosphate dehydratase
H7R62_RS10960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7R62_RS10965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7R62_RS10970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7R62_RS10980	COG1199	ATP-dependent helicase activity
H7R62_RS10985	COG1214	PFAM Peptidase M22, glycoprotease
H7R62_RS10995	COG2267	carboxylic ester hydrolase activity
H7R62_RS11000	COG0318	PFAM AMP-dependent synthetase and ligase
H7R62_RS11010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R62_RS11015	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H7R62_RS11020	COG0709	Synthesizes selenophosphate from selenide and ATP
H7R62_RS11035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R62_RS11040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7R62_RS11045	COG0840	transmembrane signaling receptor activity
H7R62_RS11050	COG1254	Belongs to the acylphosphatase family
H7R62_RS11060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R62_RS11060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R62_RS11065	COG0489	protein tyrosine kinase activity
H7R62_RS11070	COG0572	uridine kinase
H7R62_RS11075	COG0717	Belongs to the dCTP deaminase family
H7R62_RS11080	COG0306	phosphate transporter
H7R62_RS11090	COG1530	ribonuclease E activity
H7R62_RS11095	COG0564	pseudouridine synthase activity
H7R62_RS11100	COG0546	phosphoglycolate phosphatase activity
H7R62_RS11120	COG0583	DNA-binding transcription factor activity
H7R62_RS11125	COG0424	maF-like protein
H7R62_RS11130	COG1399	metal-binding, possibly nucleic acid-binding protein
H7R62_RS11135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7R62_RS11140	COG0416	fatty acid biosynthetic process
H7R62_RS11145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R62_RS11155	COG1028	Short-chain dehydrogenase reductase Sdr
H7R62_RS11160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7R62_RS11170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7R62_RS11175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7R62_RS11180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7R62_RS11185	COG0470	DNA polymerase III
H7R62_RS11190	COG0084	hydrolase, TatD family'
H7R62_RS11205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R62_RS11205	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H7R62_RS11250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R62_RS11275	COG1192	Involved in chromosome partitioning
H7R62_RS11325	COG3041	Addiction module toxin RelE StbE family
H7R62_RS11330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R62_RS11370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7R62_RS11420	COG0110	maltose O-acetyltransferase activity
H7R62_RS11435	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H7R62_RS11495	COG0789	Transcriptional regulator
H7R62_RS11505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R62_RS11545	COG3008	intermembrane lipid transfer
H7R62_RS11550	COG2995	paraquat-inducible protein a
H7R62_RS11560	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7R62_RS11565	COG0372	Belongs to the citrate synthase family
H7R62_RS11615	COG5433	transposase activity
H7R62_RS11625	COG0596	Alpha beta hydrolase
H7R62_RS11630	COG3141	response to X-ray
H7R62_RS11655	COG1067	ATP-dependent peptidase activity
H7R62_RS11660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R62_RS11670	COG0488	(ABC) transporter
H7R62_RS11680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R62_RS11680	COG0116	Belongs to the methyltransferase superfamily
H7R62_RS11685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7R62_RS11690	COG0254	rRNA binding
H7R62_RS11700	COG0167	dihydroorotate dehydrogenase activity
H7R62_RS11705	COG2902	Dehydrogenase
H7R62_RS11715	COG0308	aminopeptidase N
H7R62_RS11725	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H7R62_RS11730	COG1956	GAF domain-containing protein
H7R62_RS11740	COG3278	Belongs to the heme-copper respiratory oxidase family
H7R62_RS11755	COG2010	Cytochrome c
H7R62_RS11765	COG2217	Heavy metal translocating P-type atpase
H7R62_RS11780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R62_RS11785	COG0589	response to stress
H7R62_RS11790	COG0037	tRNA processing
H7R62_RS11815	COG1177	transmembrane transport
H7R62_RS11830	COG5654	RES domain protein
H7R62_RS11835	COG0625	glutathione transferase activity
H7R62_RS11840	COG1869	D-ribose catabolic process
H7R62_RS11845	COG1129	ABC transporter
H7R62_RS11850	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7R62_RS11855	COG1879	ABC-type sugar transport system periplasmic component
H7R62_RS11860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R62_RS11865	COG1609	Transcriptional regulator
H7R62_RS11885	COG0784	Response regulator, receiver
H7R62_RS11885	COG2205	protein histidine kinase activity
H7R62_RS11890	COG0776	regulation of translation
H7R62_RS11895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R62_RS11895	COG0072	phenylalanine-tRNA ligase activity
H7R62_RS11900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7R62_RS11905	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7R62_RS11910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7R62_RS11915	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7R62_RS11920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7R62_RS11940	COG0366	Alpha amylase catalytic
H7R62_RS11950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R62_RS11960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R62_RS11965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R62_RS11970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R62_RS11975	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H7R62_RS11980	COG3313	Fe-S protein
H7R62_RS11985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R62_RS11985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R62_RS11985	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H7R62_RS11990	COG1105	Belongs to the carbohydrate kinase PfkB family
H7R62_RS11995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R62_RS11995	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R62_RS12000	COG1609	Transcriptional regulator
H7R62_RS12005	COG0814	amino acid
H7R62_RS12010	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H7R62_RS12015	COG0513	Belongs to the DEAD box helicase family
H7R62_RS12025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7R62_RS12030	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R62_RS12035	COG2840	Smr protein MutS2
H7R62_RS12050	COG3791	Glutathione-dependent formaldehyde-activating
H7R62_RS12065	COG2824	Alkylphosphonate utilization operon protein PhnA
H7R62_RS12080	COG0494	nUDIX hydrolase
H7R62_RS12085	COG0814	amino acid
H7R62_RS12095	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H7R62_RS12100	COG0514	ATP-dependent DNA helicase (RecQ)
H7R62_RS12105	COG2766	serine protein kinase
H7R62_RS12110	COG2718	Belongs to the UPF0229 family
H7R62_RS12115	COG2719	SpoVR family
H7R62_RS12120	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R62_RS12120	COG1024	Enoyl-CoA hydratase
H7R62_RS12125	COG0183	Belongs to the thiolase family
H7R62_RS12130	COG0714	Associated with various cellular activities
H7R62_RS12150	COG2304	oxidoreductase activity
H7R62_RS12160	COG1595	DNA-templated transcription, initiation
H7R62_RS12170	COG2067	long-chain fatty acid transport protein
H7R62_RS12175	COG2067	long-chain fatty acid transport protein
H7R62_RS12180	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7R62_RS12195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7R62_RS12205	COG1643	Atp-dependent helicase
H7R62_RS12210	COG0617	tRNA 3'-terminal CCA addition
H7R62_RS12210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7R62_RS12210	COG0517	IMP dehydrogenase activity
H7R62_RS12215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R62_RS12220	COG3119	arylsulfatase activity
H7R62_RS12225	COG0714	Associated with various cellular activities
H7R62_RS12240	COG2304	oxidoreductase activity
H7R62_RS12270	COG0641	radical SAM
H7R62_RS12275	COG2326	polyphosphate kinase activity
H7R62_RS12305	COG1160	GTP binding
H7R62_RS12320	COG5433	transposase activity
H7R62_RS12325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7R62_RS12330	COG2925	Exonuclease
H7R62_RS12340	COG3345	alpha-galactosidase
H7R62_RS12345	COG1380	Effector of murein hydrolase LrgA
H7R62_RS12350	COG1346	cytolysis
H7R62_RS12355	COG0295	cytidine deaminase activity
H7R62_RS12360	COG3033	Beta-eliminating lyase
H7R62_RS12370	COG3046	protein related to deoxyribodipyrimidine photolyase
H7R62_RS12375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R62_RS12380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R62_RS12390	COG3604	Transcriptional regulator
H7R62_RS12405	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R62_RS12420	COG3158	transport of potassium into the cell
H7R62_RS12435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H7R62_RS12450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7R62_RS12460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7R62_RS12465	COG2832	Protein of unknown function (DUF454)
H7R62_RS12470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R62_RS12485	COG1011	Hydrolase
H7R62_RS12490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R62_RS12545	COG3593	DNA synthesis involved in DNA repair
H7R62_RS12565	COG0730	response to heat
H7R62_RS12570	COG3148	PFAM DTW domain containing protein
H7R62_RS12575	COG1940	carbohydrate kinase activity
H7R62_RS12575	COG1846	Transcriptional regulator
H7R62_RS12595	COG3012	SEC-C Motif Domain Protein
H7R62_RS12600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7R62_RS12605	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
H7R62_RS12610	COG0247	lactate metabolic process
H7R62_RS12635	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H7R62_RS12640	COG0437	4 iron, 4 sulfur cluster binding
H7R62_RS12645	COG3301	Polysulphide reductase, NrfD
H7R62_RS12650	COG1138	Cytochrome C-type biogenesis protein
H7R62_RS12660	COG4235	cytochrome complex assembly
H7R62_RS12660	COG3088	subunit of a heme lyase
H7R62_RS12695	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R62_RS12700	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R62_RS12705	COG0567	Dehydrogenase, E1 component
H7R62_RS12715	COG1053	succinate dehydrogenase
H7R62_RS12720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7R62_RS12755	COG1742	UPF0060 membrane protein
H7R62_RS12770	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7R62_RS12785	COG2501	S4 domain
H7R62_RS12795	COG1132	(ABC) transporter
H7R62_RS12800	COG1132	(ABC) transporter
H7R62_RS12810	COG3118	belongs to the thioredoxin family
H7R62_RS12815	COG0471	metal ion transport
H7R62_RS12820	COG0058	SHG alpha-glucan phosphorylase activity
H7R62_RS12840	COG0697	spore germination
H7R62_RS12850	COG2062	phosphohistidine phosphatase, SixA
H7R62_RS12855	COG1025	Belongs to the peptidase M16 family
H7R62_RS12885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R62_RS12885	COG0519	Catalyzes the synthesis of GMP from XMP
H7R62_RS12890	COG0517	IMP dehydrogenase activity
H7R62_RS12890	COG0516	GMP reductase activity
H7R62_RS12895	COG1278	Cold shock
H7R62_RS12900	COG1570	exodeoxyribonuclease VII activity
H7R62_RS12905	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7R62_RS12915	COG0386	Belongs to the glutathione peroxidase family
H7R62_RS12920	COG0513	Belongs to the DEAD box helicase family
H7R62_RS12930	COG0840	transmembrane signaling receptor activity
H7R62_RS12935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R62_RS12940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7R62_RS12945	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7R62_RS13000	COG5001	Diguanylate cyclase
H7R62_RS13000	COG3300	MHYT domain
H7R62_RS13015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R62_RS13025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7R62_RS13030	COG0563	adenylate kinase activity
H7R62_RS13040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7R62_RS13045	COG1286	toxin biosynthetic process
H7R62_RS13055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7R62_RS13060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7R62_RS13065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7R62_RS13070	COG1674	ftsk spoiiie
H7R62_RS13070	COG0531	amino acid
H7R62_RS13080	COG0686	Belongs to the AlaDH PNT family
H7R62_RS13085	COG0492	ferredoxin-NADP+ reductase activity
H7R62_RS13090	COG3706	GGDEF domain
H7R62_RS13095	COG3134	Outer membrane lipoprotein
H7R62_RS13100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7R62_RS13105	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7R62_RS13110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7R62_RS13115	COG0542	response to heat
H7R62_RS13120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7R62_RS13125	COG1278	Cold shock
H7R62_RS13130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7R62_RS13165	COG0745	RESPONSE REGULATOR receiver
H7R62_RS13175	COG3039	Transposase
H7R62_RS13180	COG3039	Transposase
H7R62_RS13265	COG3550	peptidyl-serine autophosphorylation
H7R62_RS13285	COG0659	secondary active sulfate transmembrane transporter activity
H7R62_RS13345	COG2814	Major facilitator Superfamily
H7R62_RS13360	COG1136	(ABC) transporter
H7R62_RS13365	COG0577	efflux transmembrane transporter activity
H7R62_RS13380	COG0596	Alpha beta hydrolase
H7R62_RS13400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R62_RS13405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R62_RS13405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7R62_RS13410	COG0527	aspartate kinase activity
H7R62_RS13430	COG0778	Nitroreductase
H7R62_RS13435	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H7R62_RS13440	COG3300	MHYT domain
H7R62_RS13440	COG5001	Diguanylate cyclase
H7R62_RS13450	COG3437	response regulator, receiver
H7R62_RS13475	COG4989	oxidoreductase activity
H7R62_RS13480	COG0724	RNA recognition motif
H7R62_RS13490	COG1126	abc transporter atp-binding protein
H7R62_RS13495	COG0765	amino acid transport
H7R62_RS13500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R62_RS13505	COG0765	amino acid transport
H7R62_RS13510	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H7R62_RS13520	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H7R62_RS13535	COG3385	transposase activity
H7R62_RS13545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R62_RS13550	COG1360	Flagellar Motor Protein
H7R62_RS13555	COG4771	TonB-dependent receptor
H7R62_RS13560	COG1770	oligopeptidase
H7R62_RS13580	COG3385	transposase activity
H7R62_RS13585	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R62_RS13590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R62_RS13595	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R62_RS13595	COG0649	NAD binding
H7R62_RS13600	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H7R62_RS13610	COG1034	ATP synthesis coupled electron transport
H7R62_RS13615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7R62_RS13620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R62_RS13625	COG0839	Belongs to the complex I subunit 6 family
H7R62_RS13630	COG0713	ATP synthesis coupled electron transport
H7R62_RS13640	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R62_RS13645	COG1007	ATP synthesis coupled electron transport
H7R62_RS13650	COG0047	phosphoribosylformylglycinamidine synthase activity
H7R62_RS13650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7R62_RS13655	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R62_RS13660	COG1645	bacterial-type flagellum-dependent swarming motility
H7R62_RS13665	COG1160	GTP binding
H7R62_RS13670	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R62_RS13675	COG2976	Protein conserved in bacteria
H7R62_RS13680	COG0124	histidyl-tRNA synthetase
H7R62_RS13685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7R62_RS13700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7R62_RS13705	COG0105	UTP biosynthetic process
H7R62_RS13720	COG0633	Ferredoxin
H7R62_RS13725	COG0443	Heat shock 70 kDa protein
H7R62_RS13730	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R62_RS13740	COG0822	iron-sulfur transferase activity
H7R62_RS13745	COG1104	cysteine desulfurase activity
H7R62_RS13750	COG1959	2 iron, 2 sulfur cluster binding
H7R62_RS13760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R62_RS13760	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R62_RS13765	COG0509	glycine decarboxylation via glycine cleavage system
H7R62_RS13770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7R62_RS13775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R62_RS13780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R62_RS13800	COG2814	Major facilitator Superfamily
H7R62_RS13805	COG0625	glutathione transferase activity
H7R62_RS13820	COG0483	inositol monophosphate 1-phosphatase activity
H7R62_RS13830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7R62_RS13850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7R62_RS13855	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H7R62_RS13860	COG2089	acid synthase
H7R62_RS13875	COG5433	transposase activity
H7R62_RS13885	COG0673	inositol 2-dehydrogenase activity
H7R62_RS13890	COG1083	cytidylyl-transferase
H7R62_RS13895	COG1028	Short-chain dehydrogenase reductase Sdr
H7R62_RS13940	COG0322	excinuclease ABC activity
H7R62_RS13945	COG2197	response regulator
H7R62_RS13950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7R62_RS13955	COG2835	tetraacyldisaccharide 4'-kinase activity
H7R62_RS13960	COG1663	tetraacyldisaccharide 4'-kinase activity
H7R62_RS13970	COG2333	competence protein COMEC
H7R62_RS13970	COG0658	competence protein
H7R62_RS13985	COG1448	Aminotransferase
H7R62_RS13995	COG0583	DNA-binding transcription factor activity
H7R62_RS14000	COG3085	chromosome segregation
H7R62_RS14005	COG4574	serine-type endopeptidase inhibitor activity
H7R62_RS14010	COG0584	glycerophosphoryl diester phosphodiesterase
H7R62_RS14020	COG1349	DNA-binding transcription factor activity
H7R62_RS14025	COG2271	Major facilitator Superfamily
H7R62_RS14030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R62_RS14035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7R62_RS14040	COG0583	DNA-binding transcription factor activity
H7R62_RS14060	COG0656	L-ascorbic acid biosynthetic process
H7R62_RS14070	COG2814	Major facilitator Superfamily
H7R62_RS14085	COG3220	belongs to the UPF0276 family
H7R62_RS14105	COG1294	oxidase, subunit
H7R62_RS14115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R62_RS14120	COG2979	Protein of unknown function (DUF533)
H7R62_RS14140	COG0583	DNA-binding transcription factor activity
H7R62_RS14150	COG2807	transmembrane transport
H7R62_RS14155	COG1187	pseudouridine synthase activity
H7R62_RS14160	COG0346	lactoylglutathione lyase activity
H7R62_RS14185	COG0270	DNA (cytosine-5-)-methyltransferase activity
H7R62_RS14195	COG4657	Part of a membrane complex involved in electron transport
H7R62_RS14200	COG2878	Part of a membrane complex involved in electron transport
H7R62_RS14210	COG4658	electron transport chain
H7R62_RS14215	COG4659	FMN binding
H7R62_RS14220	COG4660	Part of a membrane complex involved in electron transport
H7R62_RS14225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7R62_RS14230	COG0346	lactoylglutathione lyase activity
H7R62_RS14285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7R62_RS14290	COG0505	Belongs to the CarA family
H7R62_RS14300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7R62_RS14310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7R62_RS14315	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7R62_RS14320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R62_RS14325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7R62_RS14330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R62_RS14335	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H7R62_RS14365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R62_RS14370	COG0861	Integral membrane protein TerC family
H7R62_RS14385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R62_RS14390	COG0601	transmembrane transport
H7R62_RS14400	COG2095	MarC family integral membrane protein
H7R62_RS14405	COG1454	alcohol dehydrogenase
H7R62_RS14405	COG1012	belongs to the aldehyde dehydrogenase family
H7R62_RS14410	COG0217	transcriptional regulatory protein
H7R62_RS14415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7R62_RS14425	COG1801	Protein of unknown function DUF72
H7R62_RS14430	COG4106	trans-aconitate 2-methyltransferase activity
H7R62_RS14435	COG0500	methyltransferase
H7R62_RS14455	COG0450	alkyl hydroperoxide reductase
H7R62_RS14460	COG0583	DNA-binding transcription factor activity
H7R62_RS14465	COG0791	NLP P60 protein
H7R62_RS14475	COG0583	DNA-binding transcription factor activity
H7R62_RS14480	COG2610	gluconate transmembrane transporter activity
H7R62_RS14485	COG3048	D-serine ammonia-lyase activity
H7R62_RS14495	COG0538	isocitrate dehydrogenase activity
H7R62_RS14500	COG2207	Transcriptional regulator
H7R62_RS14510	COG5433	transposase activity
H7R62_RS14515	COG3537	Alpha-1,2-mannosidase
H7R62_RS14550	COG3537	Alpha-1,2-mannosidase
H7R62_RS14555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R62_RS14570	COG4521	taurine ABC transporter
H7R62_RS14575	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H7R62_RS14580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7R62_RS14585	COG2175	clavaminate synthase activity
H7R62_RS14590	COG3152	Membrane
H7R62_RS14625	COG1309	transcriptional regulator
H7R62_RS14660	COG0534	Mate efflux family protein
H7R62_RS14670	COG2841	Protein conserved in bacteria
H7R62_RS14680	COG5002	protein histidine kinase activity
H7R62_RS14680	COG5001	Diguanylate cyclase
H7R62_RS14685	COG3132	Protein of unknown function, DUF480
H7R62_RS14715	COG0708	Exodeoxyribonuclease III
H7R62_RS14740	COG1122	ATPase activity
H7R62_RS14780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R62_RS14785	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R62_RS14795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R62_RS14800	COG1120	ATPase activity
H7R62_RS14805	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R62_RS14810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R62_RS14815	COG4771	TonB-dependent receptor
H7R62_RS14820	COG2375	cellular response to nickel ion
H7R62_RS14845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R62_RS14850	COG4974	Belongs to the 'phage' integrase family
H7R62_RS14900	COG5433	transposase activity
H7R62_RS14920	COG2194	sulfuric ester hydrolase activity
H7R62_RS14935	COG0640	Transcriptional regulator
H7R62_RS14960	COG0671	phosphoesterase, PA-phosphatase related
H7R62_RS14970	COG2132	Multicopper oxidase
H7R62_RS14980	COG5642	Protein of unknown function (DUF2384)
H7R62_RS14985	COG1484	DNA-dependent DNA replication
H7R62_RS14990	COG4584	PFAM Integrase catalytic
H7R62_RS15005	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R62_RS15055	COG0328	RNA-DNA hybrid ribonuclease activity
H7R62_RS15060	COG2226	methyltransferase
H7R62_RS15065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R62_RS15070	COG0741	lytic transglycosylase activity
H7R62_RS15070	COG1388	LysM domain
H7R62_RS15100	COG1388	LysM domain
H7R62_RS15100	COG1376	ErfK ybiS ycfS ynhG family protein
H7R62_RS15110	COG0471	metal ion transport
H7R62_RS15120	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H7R62_RS15125	COG0791	NLP P60 protein
H7R62_RS15145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R62_RS15150	COG0788	formyltetrahydrofolate deformylase activity
H7R62_RS15160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R62_RS15175	COG0741	lytic transglycosylase activity
H7R62_RS15175	COG1196	nuclear chromosome segregation
H7R62_RS15175	COG0739	heme binding
H7R62_RS15180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R62_RS15190	COG0436	Aminotransferase
H7R62_RS15195	COG1288	antiporter activity
H7R62_RS15200	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7R62_RS15210	COG2964	Protein conserved in bacteria
H7R62_RS15215	COG3681	Belongs to the UPF0597 family
H7R62_RS15220	COG0251	oxidation-reduction process
H7R62_RS15225	COG0814	amino acid
H7R62_RS15245	COG1166	arginine decarboxylase activity
H7R62_RS15250	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R62_RS15265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7R62_RS15275	COG2353	YceI-like domain
H7R62_RS15280	COG0583	DNA-binding transcription factor activity
H7R62_RS15290	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H7R62_RS15295	COG0840	transmembrane signaling receptor activity
H7R62_RS15300	COG0302	gtp cyclohydrolase
H7R62_RS15310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R62_RS15320	COG2267	carboxylic ester hydrolase activity
H7R62_RS15325	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7R62_RS15340	COG0314	molybdopterin synthase activity
H7R62_RS15345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7R62_RS15350	COG0315	cyclic pyranopterin monophosphate synthase activity
H7R62_RS15355	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R62_RS15360	COG3005	denitrification pathway
H7R62_RS15370	COG0348	domain, Protein
H7R62_RS15375	COG0437	4 iron, 4 sulfur cluster binding
H7R62_RS15380	COG0243	molybdopterin cofactor binding
H7R62_RS15390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R62_RS15395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7R62_RS15400	COG3850	Histidine kinase
H7R62_RS15405	COG2197	response regulator
H7R62_RS15415	COG2205	protein histidine kinase activity
H7R62_RS15415	COG0784	Response regulator, receiver
H7R62_RS15435	COG0121	glutamine amidotransferase
H7R62_RS15440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R62_RS15445	COG1960	acyl-CoA dehydrogenase activity
H7R62_RS15450	COG1473	amidohydrolase
H7R62_RS15455	COG2914	Belongs to the UPF0125 (RnfH) family
H7R62_RS15460	COG2867	negative regulation of translational initiation
H7R62_RS15465	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7R62_RS15475	COG0582	viral genome integration into host DNA
H7R62_RS15495	COG4251	negative regulation of phosphorylation
H7R62_RS15585	COG2862	Uncharacterized protein family, UPF0114
H7R62_RS15605	COG5499	transcription regulator containing HTH domain
H7R62_RS15635	COG4584	PFAM Integrase catalytic
H7R62_RS15640	COG1484	DNA-dependent DNA replication
H7R62_RS15665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7R62_RS15675	COG1960	acyl-CoA dehydrogenase activity
H7R62_RS15680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R62_RS15690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7R62_RS15705	COG1317	bacterial-type flagellum organization
H7R62_RS15775	COG5433	transposase activity
H7R62_RS15805	COG0457	Tetratricopeptide repeat
H7R62_RS15875	COG4790	Type iii secretion
H7R62_RS15880	COG4794	Type iii secretion
H7R62_RS15885	COG4791	protein targeting
H7R62_RS15890	COG4792	protein secretion
H7R62_RS15905	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7R62_RS15910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R62_RS15910	COG1263	PTS System
H7R62_RS15915	COG1609	Transcriptional regulator
H7R62_RS15935	COG0737	Belongs to the 5'-nucleotidase family
H7R62_RS15940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R62_RS15940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R62_RS15940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R62_RS15960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R62_RS15970	COG1187	pseudouridine synthase activity
H7R62_RS15975	COG1051	belongs to the nudix hydrolase family
H7R62_RS15980	COG0482	sulfurtransferase activity
H7R62_RS15985	COG2915	High frequency lysogenization protein hflD homolog
H7R62_RS15990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7R62_RS15995	COG2850	peptidyl-arginine hydroxylation
H7R62_RS16015	COG0625	glutathione transferase activity
H7R62_RS16020	COG0259	pyridoxamine-phosphate oxidase activity
H7R62_RS16045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R62_RS16045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R62_RS16050	COG0251	oxidation-reduction process
H7R62_RS16055	COG1882	Formate acetyltransferase
H7R62_RS16060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R62_RS16070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7R62_RS16075	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7R62_RS16085	COG3385	transposase activity
H7R62_RS16090	COG2853	Lipoprotein
H7R62_RS16100	COG4235	cytochrome complex assembly
H7R62_RS16100	COG3088	subunit of a heme lyase
H7R62_RS16105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R62_RS16110	COG1138	Cytochrome C-type biogenesis protein
H7R62_RS16115	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7R62_RS16120	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R62_RS16125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R62_RS16130	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R62_RS16145	COG0835	chemotaxis
H7R62_RS16155	COG1192	Involved in chromosome partitioning
H7R62_RS16160	COG1360	Flagellar Motor Protein
H7R62_RS16165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R62_RS16170	COG2201	protein-glutamate methylesterase activity
H7R62_RS16175	COG0643	Histidine kinase
H7R62_RS16175	COG0784	Response regulator, receiver
H7R62_RS16175	COG2198	Histidine kinase
H7R62_RS16180	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H7R62_RS16205	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7R62_RS16215	COG1684	flagellar biosynthetic protein fliR
H7R62_RS16270	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7R62_RS16280	COG1677	Flagellar hook-basal body complex protein FliE
H7R62_RS16290	COG3385	transposase activity
H7R62_RS16300	COG0469	pyruvate kinase activity
H7R62_RS16305	COG1737	Transcriptional regulator
H7R62_RS16310	COG0837	glucose binding
H7R62_RS16340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R62_RS16350	COG0281	malic enzyme
H7R62_RS16375	COG0437	4 iron, 4 sulfur cluster binding
H7R62_RS16380	COG3383	formate dehydrogenase (NAD+) activity
H7R62_RS16380	COG3383	formate dehydrogenase (NAD+) activity
H7R62_RS16425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7R62_RS16435	COG3852	Histidine kinase
H7R62_RS16440	COG2204	response regulator
H7R62_RS16450	COG4662	Binding-protein-dependent transport system inner membrane component
H7R62_RS16460	COG0746	molybdenum cofactor guanylyltransferase activity
H7R62_RS16465	COG0303	'Molybdopterin
H7R62_RS16470	COG1289	transmembrane transporter activity
H7R62_RS16510	COG2205	protein histidine kinase activity
H7R62_RS16510	COG0784	Response regulator, receiver
H7R62_RS16525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R62_RS16530	COG0444	Belongs to the ABC transporter superfamily
H7R62_RS16535	COG4608	Belongs to the ABC transporter superfamily
H7R62_RS16545	COG2971	BadF BadG BcrA BcrD
H7R62_RS16570	COG3724	N-succinylarginine dihydrolase activity
H7R62_RS16590	COG2197	response regulator
H7R62_RS16595	COG5433	transposase activity
H7R62_RS16625	COG2203	Gaf domain
H7R62_RS16625	COG2200	EAL domain
H7R62_RS16625	COG2199	diguanylate cyclase activity
H7R62_RS16630	COG0826	peptidase U32
H7R62_RS16635	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R62_RS16650	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R62_RS16655	COG3706	GGDEF domain
H7R62_RS16660	COG2211	Major facilitator Superfamily
H7R62_RS16665	COG0616	signal peptide processing
H7R62_RS16675	COG1028	Short-chain dehydrogenase reductase Sdr
H7R62_RS16680	COG0583	DNA-binding transcription factor activity
H7R62_RS16690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7R62_RS16705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7R62_RS16740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7R62_RS16755	COG1301	dicarboxylic acid transport
H7R62_RS16760	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7R62_RS16765	COG2912	Transglutaminase-like superfamily
H7R62_RS16775	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R62_RS16780	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7R62_RS16785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7R62_RS16790	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H7R62_RS16795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7R62_RS16805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7R62_RS16810	COG0737	Belongs to the 5'-nucleotidase family
H7R62_RS16815	COG0193	aminoacyl-tRNA hydrolase activity
H7R62_RS16820	COG0012	GTP binding
H7R62_RS16865	COG0471	metal ion transport
H7R62_RS16865	COG0490	domain, Protein
H7R62_RS16875	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H7R62_RS16895	COG0366	Alpha amylase catalytic
H7R62_RS16905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R62_RS16920	COG1012	belongs to the aldehyde dehydrogenase family
H7R62_RS16930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7R62_RS16935	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R62_RS16945	COG0180	Tryptophanyl-tRNA synthetase
H7R62_RS16955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7R62_RS16960	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H7R62_RS16970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7R62_RS16975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7R62_RS17005	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7R62_RS17010	COG0583	DNA-binding transcription factor activity
H7R62_RS17030	COG0583	DNA-binding transcription factor activity
H7R62_RS17040	COG0739	heme binding
H7R62_RS17050	COG3264	Mechanosensitive ion channel
H7R62_RS17050	COG1511	domain protein
H7R62_RS17055	COG0584	glycerophosphoryl diester phosphodiesterase
H7R62_RS17070	COG1053	succinate dehydrogenase
H7R62_RS17075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7R62_RS17080	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R62_RS17085	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R62_RS17095	COG3214	Protein conserved in bacteria
H7R62_RS17110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R62_RS17115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R62_RS17130	COG1022	Amp-dependent synthetase and ligase
H7R62_RS17140	COG4221	oxidoreductase activity
H7R62_RS17155	COG0642	Histidine kinase
H7R62_RS17165	COG0516	GMP reductase activity
H7R62_RS17175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7R62_RS17200	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H7R62_RS17220	COG3385	transposase activity
H7R62_RS17265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R62_RS17270	COG2204	response regulator
H7R62_RS17285	COG1879	ABC-type sugar transport system periplasmic component
H7R62_RS17295	COG3706	GGDEF domain
H7R62_RS17295	COG2203	Gaf domain
H7R62_RS17295	COG5001	Diguanylate cyclase
H7R62_RS17295	COG4251	negative regulation of phosphorylation
H7R62_RS17300	COG3706	GGDEF domain
H7R62_RS17315	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R62_RS17320	COG0753	catalase activity
H7R62_RS17325	COG0583	DNA-binding transcription factor activity
H7R62_RS17330	COG5433	transposase activity
H7R62_RS17350	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R62_RS17380	COG0183	Belongs to the thiolase family
H7R62_RS17390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7R62_RS17410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R62_RS17430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R62_RS17465	COG0625	glutathione transferase activity
H7R62_RS17470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R62_RS17480	COG0583	DNA-binding transcription factor activity
H7R62_RS17490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R62_RS17505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7R62_RS17525	COG1846	Transcriptional regulator
H7R62_RS17530	COG0583	DNA-binding transcription factor activity
H7R62_RS17540	COG2948	multi-organism process
H7R62_RS17560	COG1192	Involved in chromosome partitioning
H7R62_RS17590	COG3385	transposase activity
H7R62_RS17610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R62_RS17620	COG0583	DNA-binding transcription factor activity
H7R62_RS17625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H7R62_RS17635	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R62_RS17660	COG3706	GGDEF domain
H7R62_RS17670	COG1335	isochorismatase
H7R62_RS17675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R62_RS17680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R62_RS17685	COG1702	phosphate starvation-inducible protein PhoH
H7R62_RS17690	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7R62_RS17695	COG4535	Mg2 and Co2 transporter CorC
H7R62_RS17700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7R62_RS17705	COG0789	Transcriptional regulator
H7R62_RS17720	COG1970	mechanosensitive ion channel activity
H7R62_RS17725	COG4974	Belongs to the 'phage' integrase family
H7R62_RS17730	COG0716	FMN binding
H7R62_RS17740	COG0312	modulator of DNA gyrase
H7R62_RS17745	COG2888	peptidyl-tyrosine sulfation
H7R62_RS17750	COG0495	leucyl-tRNA aminoacylation
H7R62_RS17765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7R62_RS17770	COG0799	negative regulation of ribosome biogenesis
H7R62_RS17775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7R62_RS17780	COG0768	penicillin binding
H7R62_RS17785	COG0772	Belongs to the SEDS family
H7R62_RS17790	COG2951	lytic endotransglycosylase activity
H7R62_RS17795	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7R62_RS17800	COG1686	Belongs to the peptidase S11 family
H7R62_RS17805	COG2921	Belongs to the UPF0250 family
H7R62_RS17810	COG0321	lipoyl(octanoyl) transferase activity
H7R62_RS17815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7R62_RS17835	COG3139	Protein of unknown function (DUF1315)
H7R62_RS17840	COG0252	asparaginase activity
H7R62_RS17845	COG0786	glutamate:sodium symporter activity
H7R62_RS17860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7R62_RS17865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7R62_RS17870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R62_RS17875	COG0175	sulfate reduction
H7R62_RS17880	COG2113	Glycine betaine
H7R62_RS17885	COG4176	ABC-type proline glycine betaine transport system permease component
H7R62_RS17890	COG4175	Glycine betaine
H7R62_RS17905	COG2966	Psort location CytoplasmicMembrane, score
H7R62_RS17915	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R62_RS17930	COG2897	thiosulfate sulfurtransferase activity
H7R62_RS17935	COG2066	Belongs to the glutaminase family
H7R62_RS17940	COG3171	Protein conserved in bacteria
H7R62_RS17945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7R62_RS17950	COG4935	Belongs to the peptidase S8 family
H7R62_RS17950	COG2234	aminopeptidase activity
H7R62_RS17955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R62_RS17960	COG2200	EAL domain
H7R62_RS17965	COG1090	epimerase
H7R62_RS17970	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H7R62_RS17975	COG4181	ATPase activity
H7R62_RS17980	COG2755	lipolytic protein G-D-S-L family
H7R62_RS17985	COG0784	Response regulator, receiver
H7R62_RS17985	COG0835	chemotaxis
H7R62_RS18025	COG3397	chitin binding
H7R62_RS18035	COG3706	GGDEF domain
H7R62_RS18045	COG5002	protein histidine kinase activity
H7R62_RS18045	COG2205	protein histidine kinase activity
H7R62_RS18045	COG0784	Response regulator, receiver
H7R62_RS18055	COG3655	Transcriptional regulator
H7R62_RS18065	COG2814	Major facilitator Superfamily
H7R62_RS18090	COG0748	coenzyme F420 binding
H7R62_RS18095	COG3721	Heme iron utilization protein
H7R62_RS18105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R62_RS18120	COG3275	phosphorelay sensor kinase activity
H7R62_RS18125	COG3279	Response regulator of the LytR AlgR family
H7R62_RS18130	COG1966	Carbon starvation protein
H7R62_RS18135	COG3340	Belongs to the peptidase S51 family
H7R62_RS18145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R62_RS18160	COG1047	Peptidyl-prolyl cis-trans
H7R62_RS18165	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H7R62_RS18175	COG0835	chemotaxis
H7R62_RS18175	COG0784	Response regulator, receiver
H7R62_RS18180	COG0429	hydrolase of the alpha beta-hydrolase fold
H7R62_RS18185	COG3706	GGDEF domain
H7R62_RS18190	COG3089	Belongs to the UPF0270 family
H7R62_RS18195	COG3954	Phosphoribulokinase
H7R62_RS18210	COG1765	OsmC-like protein
H7R62_RS18250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R62_RS18255	COG2313	pseudouridylate synthase activity
H7R62_RS18280	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
H7R62_RS18305	COG0569	domain protein
H7R62_RS18305	COG2985	domain, Protein
H7R62_RS18310	COG1272	protein, Hemolysin III
H7R62_RS18315	COG0076	glutamate decarboxylase activity
H7R62_RS18320	COG2917	probably involved in intracellular septation
H7R62_RS18325	COG2350	Protein conserved in bacteria
H7R62_RS18335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7R62_RS18340	COG1381	Involved in DNA repair and RecF pathway recombination
H7R62_RS18355	COG0681	Belongs to the peptidase S26 family
H7R62_RS18360	COG0481	GTPase activity
H7R62_RS18370	COG3026	antisigma factor binding
H7R62_RS18375	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H7R62_RS18380	COG1595	DNA-templated transcription, initiation
H7R62_RS18385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7R62_RS18395	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H7R62_RS18400	COG0354	folic acid binding
H7R62_RS18425	COG4232	protein-disulfide reductase activity
H7R62_RS18445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R62_RS18450	COG0191	fructose-bisphosphate aldolase activity
H7R62_RS18455	COG0126	phosphoglycerate kinase activity
H7R62_RS18460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R62_RS18465	COG1940	carbohydrate kinase activity
H7R62_RS18470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7R62_RS18475	COG2816	NAD+ diphosphatase activity
H7R62_RS18485	COG4991	sh3 domain protein
H7R62_RS18490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R62_RS18505	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7R62_RS18520	COG0745	RESPONSE REGULATOR receiver
H7R62_RS18535	COG2816	NAD+ diphosphatase activity
H7R62_RS18580	COG1858	cytochrome C peroxidase
H7R62_RS18585	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
H7R62_RS18595	COG5001	Diguanylate cyclase
H7R62_RS18600	COG0513	Belongs to the DEAD box helicase family
H7R62_RS18635	COG0154	amidase activity
H7R62_RS18640	COG2957	Belongs to the agmatine deiminase family
H7R62_RS18655	COG1902	pentaerythritol trinitrate reductase activity
H7R62_RS18670	COG1238	metal cluster binding
H7R62_RS18675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7R62_RS18680	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7R62_RS18685	COG0585	pseudouridine synthase activity
H7R62_RS18695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7R62_RS18700	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7R62_RS18705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R62_RS18715	COG1376	ErfK ybiS ycfS ynhG family protein
H7R62_RS18720	COG0668	transmembrane transport
H7R62_RS18730	COG2731	YhcH YjgK YiaL family protein
H7R62_RS18740	COG1794	racemase activity, acting on amino acids and derivatives
H7R62_RS18755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R62_RS18775	COG0488	(ABC) transporter
H7R62_RS18785	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7R62_RS18820	COG0148	phosphopyruvate hydratase activity
H7R62_RS18825	COG0504	CTP synthase activity
H7R62_RS18830	COG3956	TIGRFAM MazG family protein
H7R62_RS18835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R62_RS18840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R62_RS18850	COG4807	Protein conserved in bacteria
H7R62_RS18855	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7R62_RS18860	COG0783	Belongs to the Dps family
H7R62_RS18865	COG1151	hydroxylamine reductase activity
H7R62_RS18870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R62_RS18875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R62_RS18880	COG0671	phosphoesterase, PA-phosphatase related
H7R62_RS18885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R62_RS18890	COG0163	prenyltransferase activity
H7R62_RS18905	COG1131	(ABC) transporter
H7R62_RS18910	COG0842	Transport permease protein
H7R62_RS18915	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
H7R62_RS18920	COG1924	4 iron, 4 sulfur cluster binding
H7R62_RS18935	COG1129	ABC transporter
H7R62_RS18945	COG1486	melibiose metabolic process
H7R62_RS18960	COG1823	symporter activity
H7R62_RS18970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7R62_RS18975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7R62_RS18980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7R62_RS18985	COG0617	tRNA 3'-terminal CCA addition
H7R62_RS18990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R62_RS18995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7R62_RS19000	COG1489	DNA binding
H7R62_RS19010	COG1643	Atp-dependent helicase
H7R62_RS19015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R62_RS19020	COG0346	lactoylglutathione lyase activity
H7R62_RS19025	COG2076	Multidrug Resistance protein
H7R62_RS19030	COG2076	Multidrug Resistance protein
H7R62_RS19035	COG0583	DNA-binding transcription factor activity
H7R62_RS19040	COG3437	response regulator, receiver
H7R62_RS19040	COG0784	Response regulator, receiver
H7R62_RS19045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7R62_RS19060	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H7R62_RS19075	COG1136	(ABC) transporter
H7R62_RS19095	COG0840	transmembrane signaling receptor activity
H7R62_RS19115	COG3039	Transposase
H7R62_RS19120	COG0529	Catalyzes the synthesis of activated sulfate
H7R62_RS19125	COG0471	metal ion transport
H7R62_RS19125	COG3273	potassium ion transport
H7R62_RS19130	COG2895	sulfate adenylyltransferase (ATP) activity
H7R62_RS19135	COG0175	sulfate reduction
H7R62_RS19140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R62_RS19140	COG1648	precorrin-2 dehydrogenase activity
H7R62_RS19145	COG0330	HflC and HflK could
H7R62_RS19150	COG1585	Membrane protein implicated in regulation of membrane protease activity
H7R62_RS19155	COG0840	transmembrane signaling receptor activity
H7R62_RS19160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7R62_RS19165	COG0676	glucose-6-phosphate 1-epimerase activity
H7R62_RS19170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R62_RS19175	COG1640	4-alpha-glucanotransferase
H7R62_RS19180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7R62_RS19230	COG0561	phosphatase activity
H7R62_RS19245	COG0733	neurotransmitter:sodium symporter activity
H7R62_RS19265	COG0733	neurotransmitter:sodium symporter activity
H7R62_RS19330	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H7R62_RS19335	COG2885	chlorophyll binding
H7R62_RS19340	COG0823	Involved in the tonB-independent uptake of proteins
H7R62_RS19355	COG0811	peptide transport
H7R62_RS19360	COG0824	Thioesterase
H7R62_RS19365	COG3790	cyd operon protein YbgE
H7R62_RS19370	COG4890	Cyd operon protein YbgT
H7R62_RS19375	COG1294	oxidase, subunit
H7R62_RS19385	COG2255	four-way junction helicase activity
H7R62_RS19390	COG0632	four-way junction helicase activity
H7R62_RS19410	COG2771	luxR family
H7R62_RS19415	COG3916	Acyl-homoserine-lactone synthase
H7R62_RS19425	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H7R62_RS19430	COG5001	Diguanylate cyclase
H7R62_RS19430	COG4251	negative regulation of phosphorylation
H7R62_RS19430	COG3706	GGDEF domain
H7R62_RS19430	COG2203	Gaf domain
H7R62_RS19440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R62_RS19450	COG2995	paraquat-inducible protein a
H7R62_RS19455	COG3008	intermembrane lipid transfer
H7R62_RS19455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R62_RS19465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R62_RS19470	COG0442	prolyl-tRNA aminoacylation
H7R62_RS19475	COG4221	oxidoreductase activity
H7R62_RS19490	COG1024	Enoyl-CoA hydratase
H7R62_RS19500	COG0110	maltose O-acetyltransferase activity
H7R62_RS19510	COG4166	transmembrane transport
H7R62_RS19520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R62_RS19530	COG3385	transposase activity
H7R62_RS19535	COG3039	Transposase
H7R62_RS19540	COG0456	acetyltransferase
H7R62_RS19545	COG0735	belongs to the Fur family
H7R62_RS19570	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7R62_RS19575	COG0513	Belongs to the DEAD box helicase family
H7R62_RS19580	COG2153	protein acetylation
H7R62_RS19590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R62_RS19595	COG0557	exoribonuclease II activity
H7R62_RS19600	COG3706	GGDEF domain
H7R62_RS19610	COG3240	lipase activity
H7R62_RS19615	COG3111	PFAM Bacterial OB fold (BOF) protein
H7R62_RS19625	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H7R62_RS19630	COG1194	a g-specific adenine glycosylase
H7R62_RS19635	COG0617	tRNA 3'-terminal CCA addition
H7R62_RS19655	COG3068	Protein conserved in bacteria
H7R62_RS19665	COG0739	heme binding
H7R62_RS19695	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H7R62_RS19700	COG1121	(ABC) transporter
H7R62_RS19705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7R62_RS19710	COG0583	DNA-binding transcription factor activity
H7R62_RS19720	COG1573	uracil-dna glycosylase
H7R62_RS19735	COG2827	Endonuclease containing a URI domain
H7R62_RS19750	COG1842	Phage shock protein A
H7R62_RS19755	COG0204	Acyl-transferase
H7R62_RS19775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R62_RS19780	COG0484	heat shock protein binding
H7R62_RS19800	COG3104	oligopeptide transport
H7R62_RS19835	COG3150	esterase
H7R62_RS19845	COG3151	Protein conserved in bacteria
H7R62_RS19850	COG0494	nUDIX hydrolase
H7R62_RS19855	COG1538	Outer membrane efflux protein
H7R62_RS19860	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7R62_RS19860	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7R62_RS19865	COG1560	Kdo2-lipid A biosynthetic process
H7R62_RS19870	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R62_RS19870	COG2213	PTS system mannitol-specific
H7R62_RS19875	COG0246	Mannitol dehydrogenase
H7R62_RS19880	COG3722	fumarate hydratase activity
H7R62_RS19905	COG1671	Belongs to the UPF0178 family
H7R62_RS19910	COG1988	membrane-bound metal-dependent
H7R62_RS19915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R62_RS19920	COG0513	Belongs to the DEAD box helicase family
H7R62_RS19940	COG1575	Belongs to the MenA family. Type 1 subfamily
H7R62_RS19945	COG1169	isochorismate synthase
H7R62_RS19950	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H7R62_RS19955	COG0596	Alpha beta hydrolase
H7R62_RS19965	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7R62_RS19970	COG1441	menaquinone biosynthetic process
H7R62_RS19975	COG0318	PFAM AMP-dependent synthetase and ligase
H7R62_RS19980	COG3291	Pkd domain containing protein
H7R62_RS19985	COG2949	membrane
H7R62_RS19990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7R62_RS20000	COG0835	chemotaxis
H7R62_RS20000	COG0784	Response regulator, receiver
H7R62_RS20005	COG1028	Short-chain dehydrogenase reductase Sdr
H7R62_RS20010	COG1444	tRNA N-acetyltransferase activity
H7R62_RS20035	COG1803	Methylglyoxal synthase
H7R62_RS20040	COG1979	alcohol dehydrogenase
H7R62_RS20060	COG4221	oxidoreductase activity
H7R62_RS20095	COG1368	sulfuric ester hydrolase activity
H7R62_RS20100	COG1522	sequence-specific DNA binding
H7R62_RS20110	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H7R62_RS20120	COG1546	Belongs to the CinA family
H7R62_RS20120	COG1058	Belongs to the CinA family
H7R62_RS20130	COG0561	phosphatase activity
H7R62_RS20140	COG2926	Belongs to the UPF0265 family
H7R62_RS20175	COG1396	sequence-specific DNA binding
H7R62_RS20180	COG3135	benzoate transporter
H7R62_RS20215	COG0840	transmembrane signaling receptor activity
H7R62_RS20220	COG3047	cAMP biosynthetic process
H7R62_RS20230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7R62_RS20245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7R62_RS20255	COG1278	Cold shock
H7R62_RS20260	COG2252	PERMEase
H7R62_RS20265	COG2376	Dihydroxyacetone kinase
H7R62_RS20270	COG1461	Dihydroxyacetone kinase
H7R62_RS20275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7R62_RS20275	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H7R62_RS20275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R62_RS20285	COG3284	Transcriptional regulator
H7R62_RS20295	COG5433	transposase activity
H7R62_RS20310	COG0583	DNA-binding transcription factor activity
H7R62_RS20315	COG2957	Belongs to the agmatine deiminase family
H7R62_RS20330	COG0628	permease
H7R62_RS20335	COG0494	nUDIX hydrolase
H7R62_RS20350	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7R62_RS20355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7R62_RS20375	COG0456	acetyltransferase
H7R62_RS20380	COG3133	Outer membrane lipoprotein
H7R62_RS20385	COG0004	ammonium transporteR
H7R62_RS20390	COG3706	GGDEF domain
H7R62_RS20400	COG3932	Exopolysaccharide synthesis, ExoD
H7R62_RS20405	COG0814	amino acid
H7R62_RS20420	COG0110	maltose O-acetyltransferase activity
H7R62_RS20425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7R62_RS20435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7R62_RS20440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R62_RS20450	COG0137	argininosuccinate synthase activity
H7R62_RS20455	COG0165	Argininosuccinate lyase
H7R62_RS20485	COG3314	Sporulation integral membrane protein YlbJ
H7R62_RS20510	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7R62_RS20515	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7R62_RS20530	COG0477	Major facilitator Superfamily
H7R62_RS20535	COG0523	cobalamin synthesis protein
H7R62_RS20545	COG1280	lysine exporter protein (LysE YggA)
H7R62_RS20560	COG1028	Short-chain dehydrogenase reductase Sdr
H7R62_RS20565	COG2200	EAL domain
H7R62_RS20575	COG1049	propionate catabolic process, 2-methylcitrate cycle
H7R62_RS20580	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R62_RS20585	COG0840	transmembrane signaling receptor activity
H7R62_RS20595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R62_RS20600	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R62_RS20605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7R62_RS20610	COG2186	Transcriptional regulator
H7R62_RS20635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R62_RS20640	COG1459	type II secretion system
H7R62_RS20655	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H7R62_RS20660	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H7R62_RS20665	COG0494	nUDIX hydrolase
H7R62_RS20670	COG0653	protein targeting
H7R62_RS20680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7R62_RS20685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7R62_RS20690	COG0849	cell division
H7R62_RS20700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R62_RS20705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7R62_RS20710	COG0772	Belongs to the SEDS family
H7R62_RS20715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7R62_RS20720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7R62_RS20725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7R62_RS20735	COG0768	penicillin binding
H7R62_RS20740	COG3116	cell division
H7R62_RS20745	COG0275	rRNA processing
H7R62_RS20750	COG2001	Belongs to the MraZ family
H7R62_RS20775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7R62_RS20780	COG3107	peptidoglycan biosynthetic process
H7R62_RS20785	COG0792	nuclease activity
H7R62_RS20790	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R62_RS20800	COG2969	positive regulation of protein catabolic process
H7R62_RS20805	COG0625	glutathione transferase activity
H7R62_RS20810	COG2857	Cytochrome c1
H7R62_RS20815	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7R62_RS20820	COG0723	plastoquinol--plastocyanin reductase activity
H7R62_RS20825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7R62_RS20830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7R62_RS20835	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7R62_RS20845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R62_RS20850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R62_RS20855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R62_RS20860	COG1660	Displays ATPase and GTPase activities
H7R62_RS20865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R62_RS20880	COG1137	ATPase activity
H7R62_RS20885	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7R62_RS20890	COG3117	lipopolysaccharide transmembrane transporter activity
H7R62_RS20895	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7R62_RS20900	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7R62_RS20900	COG0517	IMP dehydrogenase activity
H7R62_RS20905	COG1127	ABC transporter
H7R62_RS20910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7R62_RS20915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R62_RS20920	COG2854	intermembrane phospholipid transfer
H7R62_RS20930	COG5007	Belongs to the BolA IbaG family
H7R62_RS20935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7R62_RS20940	COG0312	modulator of DNA gyrase
H7R62_RS20945	COG3028	Belongs to the UPF0307 family
H7R62_RS20950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7R62_RS20960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R62_RS20970	COG1011	Hydrolase
H7R62_RS20985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7R62_RS20990	COG0019	diaminopimelate decarboxylase activity
H7R62_RS21000	COG1965	Belongs to the frataxin family
H7R62_RS21005	COG0400	carboxylic ester hydrolase activity
H7R62_RS21010	COG3072	Adenylate cyclase
H7R62_RS21015	COG0181	hydroxymethylbilane synthase activity
H7R62_RS21025	COG2959	enzyme of heme biosynthesis
H7R62_RS21040	COG1494	fructose-1,6-bisphosphatase
H7R62_RS21095	COG0795	lipopolysaccharide-transporting ATPase activity
H7R62_RS21100	COG0795	lipopolysaccharide-transporting ATPase activity
H7R62_RS21105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R62_RS21110	COG2927	DNA polymerase III (CHI subunit)
H7R62_RS21135	COG0456	acetyltransferase
H7R62_RS21135	COG0454	-acetyltransferase
H7R62_RS21140	COG0753	catalase activity
H7R62_RS21165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R62_RS21170	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7R62_RS21175	COG5380	lipid catabolic process
H7R62_RS21195	COG4533	DNA binding
H7R62_RS21205	COG2873	o-acetylhomoserine
H7R62_RS21210	COG3385	transposase activity
H7R62_RS21240	COG3842	ATPase activity
H7R62_RS21250	COG1175	transmembrane transport
H7R62_RS21285	COG5433	transposase activity
H7R62_RS21315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R62_RS21320	COG1074	ATP-dependent DNA helicase activity
H7R62_RS21325	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7R62_RS21330	COG2259	Doxx family
H7R62_RS21335	COG1741	Belongs to the pirin family
H7R62_RS21345	COG0583	DNA-binding transcription factor activity
H7R62_RS21375	COG3706	GGDEF domain
H7R62_RS21380	COG4771	TonB-dependent receptor
H7R62_RS21425	COG0203	ribosomal protein L17
H7R62_RS21430	COG0202	RNA polymerase activity
H7R62_RS21435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7R62_RS21440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7R62_RS21445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7R62_RS21450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7R62_RS21455	COG0201	protein transport
H7R62_RS21460	COG0200	Binds to the 23S rRNA
H7R62_RS21465	COG1841	ribosomal large subunit assembly
H7R62_RS21470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7R62_RS21475	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7R62_RS21480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7R62_RS21485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7R62_RS21490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7R62_RS21495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7R62_RS21500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7R62_RS21505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7R62_RS21510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7R62_RS21515	COG0255	Belongs to the universal ribosomal protein uL29 family
H7R62_RS21520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7R62_RS21525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7R62_RS21530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7R62_RS21535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7R62_RS21540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7R62_RS21545	COG0089	rRNA binding
H7R62_RS21550	COG0088	Forms part of the polypeptide exit tunnel
H7R62_RS21555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7R62_RS21560	COG0051	transcription antitermination factor activity, RNA binding
H7R62_RS21580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R62_RS21585	COG2183	response to ionizing radiation
H7R62_RS21605	COG0596	Alpha beta hydrolase
H7R62_RS21610	COG1040	competence protein
H7R62_RS21615	COG0316	Belongs to the HesB IscA family
H7R62_RS21615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7R62_RS21620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7R62_RS21625	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7R62_RS21630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R62_RS21635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7R62_RS21640	COG4942	peptidase
H7R62_RS21650	COG1609	Transcriptional regulator
H7R62_RS21655	COG0800	Aldolase
H7R62_RS21660	COG0129	dihydroxy-acid dehydratase activity
H7R62_RS21665	COG3265	gluconokinase activity
H7R62_RS21670	COG2610	gluconate transmembrane transporter activity
H7R62_RS21675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R62_RS21680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7R62_RS21690	COG0456	acetyltransferase
H7R62_RS21695	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7R62_RS21700	COG1490	D-aminoacyl-tRNA deacylase activity
H7R62_RS21705	COG1295	ribonuclease BN
H7R62_RS21710	COG0281	malic enzyme
H7R62_RS21715	COG0814	amino acid
H7R62_RS21720	COG0702	epimerase
H7R62_RS21730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7R62_RS21735	COG0254	rRNA binding
H7R62_RS21750	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R62_RS21755	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7R62_RS21765	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7R62_RS21775	COG0514	ATP-dependent DNA helicase (RecQ)
H7R62_RS21780	COG2050	protein possibly involved in aromatic compounds catabolism
H7R62_RS21795	COG2258	MOSC domain
H7R62_RS21800	COG1177	transmembrane transport
H7R62_RS21805	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R62_RS21810	COG3842	ATPase activity
H7R62_RS21830	COG0174	glutamine synthetase
H7R62_RS21850	COG3045	CreA protein
H7R62_RS21855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R62_RS21860	COG0443	Heat shock 70 kDa protein
H7R62_RS21875	COG0366	Alpha amylase catalytic
H7R62_RS21880	COG3385	transposase activity
H7R62_RS21895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R62_RS21905	COG4211	Belongs to the binding-protein-dependent transport system permease family
H7R62_RS21920	COG3250	beta-galactosidase activity
H7R62_RS21925	COG1609	Transcriptional regulator
H7R62_RS21930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R62_RS21940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7R62_RS21945	COG2017	converts alpha-aldose to the beta-anomer
H7R62_RS21950	COG1968	undecaprenyl-diphosphatase activity
H7R62_RS21960	COG1595	DNA-templated transcription, initiation
H7R62_RS21970	COG0018	arginyl-trna synthetase
H7R62_RS21980	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7R62_RS21985	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7R62_RS21995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R62_RS22000	COG1131	(ABC) transporter
H7R62_RS22005	COG0842	Transport permease protein
H7R62_RS22010	COG0842	Transport permease protein
H7R62_RS22015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R62_RS22025	COG2116	formate transmembrane transporter activity
H7R62_RS22030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R62_RS22030	COG1648	precorrin-2 dehydrogenase activity
H7R62_RS22035	COG2239	Acts as a magnesium transporter
H7R62_RS22040	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7R62_RS22045	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7R62_RS22050	COG3845	ABC transporter
H7R62_RS22055	COG1744	ABC transporter substrate-binding protein PnrA-like
H7R62_RS22070	COG0210	DNA helicase
H7R62_RS22085	COG1943	Transposase
H7R62_RS22135	COG1280	lysine exporter protein (LysE YggA)
H7R62_RS22175	COG3306	glycosyltransferase involved in LPS biosynthesis
H7R62_RS22180	COG3307	-O-antigen
H7R62_RS22195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R62_RS22210	COG1063	alcohol dehydrogenase
H7R62_RS22215	COG3245	cytochrome
H7R62_RS22230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7R62_RS22235	COG2166	iron-sulfur cluster assembly
H7R62_RS22240	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7R62_RS22265	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H7R62_RS22270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R62_RS22275	COG1739	Uncharacterized protein family UPF0029
H7R62_RS22280	COG0006	proline dipeptidase activity
H7R62_RS22285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R62_RS22290	COG1024	Enoyl-CoA hydratase
H7R62_RS22290	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R62_RS22295	COG0183	Belongs to the thiolase family
H7R62_RS22320	COG0425	Belongs to the sulfur carrier protein TusA family
H7R62_RS22325	COG0251	oxidation-reduction process
H7R62_RS22335	COG2885	chlorophyll binding
H7R62_RS22350	COG2818	Glycosylase
H7R62_RS22355	COG0752	glycyl-tRNA synthetase alpha subunit
H7R62_RS22360	COG0751	glycine-tRNA ligase activity
H7R62_RS22405	COG1609	Transcriptional regulator
H7R62_RS22435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R62_RS22450	COG2960	long-chain fatty acid transporting porin activity
H7R62_RS22455	COG5001	Diguanylate cyclase
H7R62_RS22465	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7R62_RS22480	COG3118	belongs to the thioredoxin family
H7R62_RS22485	COG0513	Belongs to the DEAD box helicase family
H7R62_RS22490	COG0248	Ppx GppA phosphatase
H7R62_RS22500	COG0742	ribosomal rna small subunit methyltransferase
H7R62_RS22510	COG3385	transposase activity
H7R62_RS22520	COG3469	chitinase activity
H7R62_RS22530	COG0084	hydrolase, TatD family'
H7R62_RS22535	COG0805	protein transport
H7R62_RS22540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R62_RS22545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R62_RS22550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7R62_RS22555	COG3165	ubiquinone biosynthetic process from chorismate
H7R62_RS22560	COG2226	methyltransferase
H7R62_RS22565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7R62_RS22570	COG0402	S-adenosylhomocysteine deaminase activity
H7R62_RS22575	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H7R62_RS22610	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H7R62_RS22615	COG0848	biopolymer transport protein
H7R62_RS22620	COG0811	peptide transport
H7R62_RS22625	COG0811	peptide transport
H7R62_RS22635	COG2771	luxR family
H7R62_RS22645	COG1111	helicase
H7R62_RS22645	COG1205	dead DEAH box helicase
H7R62_RS22775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7R62_RS22780	COG1349	DNA-binding transcription factor activity
H7R62_RS22785	COG0745	RESPONSE REGULATOR receiver
H7R62_RS22790	COG2205	protein histidine kinase activity
H7R62_RS22805	COG4452	Inner membrane protein CreD
H7R62_RS22810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7R62_RS22815	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7R62_RS22820	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7R62_RS22825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7R62_RS22830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7R62_RS22835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7R62_RS22840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7R62_RS22850	COG0356	it plays a direct role in the translocation of protons across the membrane
H7R62_RS22860	COG1475	DNA binding
H7R62_RS22865	COG1192	Involved in chromosome partitioning
H7R62_RS22870	COG0357	Ribosomal RNA small subunit methyltransferase G
H7R62_RS22875	COG0445	tRNA wobble uridine modification
H7R62_RS22880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7R62_RS22885	COG4774	siderophore transport
H7R62_RS22890	COG4615	Cyclic peptide transporter
H7R62_RS22895	COG1120	ATPase activity
H7R62_RS22900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R62_RS22905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R62_RS22910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7R62_RS22915	COG0706	membrane insertase activity
H7R62_RS22920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7R62_RS22925	COG0594	ribonuclease P activity
H7R62_RS22930	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7R62_RS22935	COG1126	abc transporter atp-binding protein
H7R62_RS22975	COG3077	Addiction module antitoxin, RelB DinJ family
H7R62_RS22980	COG2026	Addiction module toxin, RelE StbE family