locus-tag	class	description
H7R84_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7R84_RS00010	COG0592	DNA-directed DNA polymerase activity
H7R84_RS00020	COG0187	DNA topoisomerase II activity
H7R84_RS00035	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7R84_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R84_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R84_RS00050	COG3977	Valine--pyruvate aminotransferase
H7R84_RS00065	COG2814	Major facilitator Superfamily
H7R84_RS00070	COG0745	RESPONSE REGULATOR receiver
H7R84_RS00075	COG2205	protein histidine kinase activity
H7R84_RS00095	COG1733	regulation of RNA biosynthetic process
H7R84_RS00105	COG0604	alcohol dehydrogenase
H7R84_RS00115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R84_RS00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R84_RS00120	COG4191	Histidine kinase
H7R84_RS00125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R84_RS00130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R84_RS00135	COG1309	transcriptional regulator
H7R84_RS00165	COG0469	pyruvate kinase activity
H7R84_RS00170	COG2271	Major facilitator Superfamily
H7R84_RS00195	COG0561	phosphatase activity
H7R84_RS00200	COG2267	carboxylic ester hydrolase activity
H7R84_RS00205	COG0110	maltose O-acetyltransferase activity
H7R84_RS00210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R84_RS00215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R84_RS00220	COG1758	RNA polymerase activity
H7R84_RS00225	COG0194	GDP metabolic process
H7R84_RS00230	COG0859	PFAM glycosyl transferase family 9
H7R84_RS00235	COG3642	lipopolysaccharide core region biosynthetic process
H7R84_RS00275	COG0589	response to stress
H7R84_RS00280	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7R84_RS00285	COG1528	Iron-storage protein
H7R84_RS00290	COG2081	HI0933 family
H7R84_RS00295	COG3275	phosphorelay sensor kinase activity
H7R84_RS00300	COG3279	Response regulator of the LytR AlgR family
H7R84_RS00305	COG2223	nitrite transmembrane transporter activity
H7R84_RS00310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7R84_RS00315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7R84_RS00330	COG0583	DNA-binding transcription factor activity
H7R84_RS00370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7R84_RS00375	COG2166	iron-sulfur cluster assembly
H7R84_RS00380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7R84_RS00395	COG3245	cytochrome
H7R84_RS00400	COG1063	alcohol dehydrogenase
H7R84_RS00415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R84_RS00430	COG3307	-O-antigen
H7R84_RS00435	COG3306	glycosyltransferase involved in LPS biosynthesis
H7R84_RS00470	COG1280	lysine exporter protein (LysE YggA)
H7R84_RS00510	COG1943	Transposase
H7R84_RS00525	COG0210	DNA helicase
H7R84_RS00530	COG1744	ABC transporter substrate-binding protein PnrA-like
H7R84_RS00535	COG3845	ABC transporter
H7R84_RS00540	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7R84_RS00545	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7R84_RS00550	COG2239	Acts as a magnesium transporter
H7R84_RS00555	COG1648	precorrin-2 dehydrogenase activity
H7R84_RS00555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R84_RS00560	COG2116	formate transmembrane transporter activity
H7R84_RS00570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R84_RS00575	COG0842	Transport permease protein
H7R84_RS00580	COG0842	Transport permease protein
H7R84_RS00585	COG1131	(ABC) transporter
H7R84_RS00590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R84_RS00605	COG0477	Major facilitator Superfamily
H7R84_RS00610	COG3385	transposase activity
H7R84_RS00615	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7R84_RS00620	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7R84_RS00630	COG0018	arginyl-trna synthetase
H7R84_RS00640	COG1595	DNA-templated transcription, initiation
H7R84_RS00650	COG1968	undecaprenyl-diphosphatase activity
H7R84_RS00655	COG2017	converts alpha-aldose to the beta-anomer
H7R84_RS00660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7R84_RS00665	COG1085	galactose-1-phosphate uridylyltransferase
H7R84_RS00670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R84_RS00675	COG1609	Transcriptional regulator
H7R84_RS00680	COG3250	beta-galactosidase activity
H7R84_RS00695	COG4211	Belongs to the binding-protein-dependent transport system permease family
H7R84_RS00705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R84_RS00720	COG0366	Alpha amylase catalytic
H7R84_RS00735	COG0443	Heat shock 70 kDa protein
H7R84_RS00740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R84_RS00745	COG3045	CreA protein
H7R84_RS00765	COG0174	glutamine synthetase
H7R84_RS00785	COG3842	ATPase activity
H7R84_RS00790	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R84_RS00795	COG1177	transmembrane transport
H7R84_RS00800	COG2258	MOSC domain
H7R84_RS00845	COG0732	type I restriction modification DNA specificity domain
H7R84_RS00900	COG2050	protein possibly involved in aromatic compounds catabolism
H7R84_RS00905	COG0514	ATP-dependent DNA helicase (RecQ)
H7R84_RS00910	COG0514	ATP-dependent DNA helicase (RecQ)
H7R84_RS00920	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7R84_RS00930	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7R84_RS00935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R84_RS00950	COG0254	rRNA binding
H7R84_RS00955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7R84_RS00965	COG0702	epimerase
H7R84_RS00970	COG0814	amino acid
H7R84_RS00975	COG0281	malic enzyme
H7R84_RS00980	COG1295	ribonuclease BN
H7R84_RS00985	COG1490	D-aminoacyl-tRNA deacylase activity
H7R84_RS00990	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7R84_RS00995	COG0456	acetyltransferase
H7R84_RS01005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7R84_RS01010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R84_RS01015	COG2610	gluconate transmembrane transporter activity
H7R84_RS01020	COG3265	gluconokinase activity
H7R84_RS01025	COG0129	dihydroxy-acid dehydratase activity
H7R84_RS01030	COG0800	Aldolase
H7R84_RS01035	COG1609	Transcriptional regulator
H7R84_RS01045	COG4942	peptidase
H7R84_RS01050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7R84_RS01055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R84_RS01060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7R84_RS01065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7R84_RS01070	COG0316	Belongs to the HesB IscA family
H7R84_RS01070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7R84_RS01075	COG1040	competence protein
H7R84_RS01080	COG0596	Alpha beta hydrolase
H7R84_RS01100	COG2183	response to ionizing radiation
H7R84_RS01105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R84_RS01125	COG0051	transcription antitermination factor activity, RNA binding
H7R84_RS01130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7R84_RS01135	COG0088	Forms part of the polypeptide exit tunnel
H7R84_RS01140	COG0089	rRNA binding
H7R84_RS01145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7R84_RS01150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7R84_RS01155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7R84_RS01160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7R84_RS01165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7R84_RS01170	COG0255	Belongs to the universal ribosomal protein uL29 family
H7R84_RS01175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7R84_RS01180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7R84_RS01185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7R84_RS01190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7R84_RS01195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7R84_RS01200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7R84_RS01205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7R84_RS01210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7R84_RS01215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7R84_RS01220	COG1841	ribosomal large subunit assembly
H7R84_RS01225	COG0200	Binds to the 23S rRNA
H7R84_RS01230	COG0201	protein transport
H7R84_RS01235	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7R84_RS01240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7R84_RS01245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7R84_RS01250	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7R84_RS01255	COG0202	RNA polymerase activity
H7R84_RS01260	COG0203	ribosomal protein L17
H7R84_RS01315	COG3714	YhhN family
H7R84_RS01340	COG1301	dicarboxylic acid transport
H7R84_RS01350	COG2095	MarC family integral membrane protein
H7R84_RS01355	COG0583	DNA-binding transcription factor activity
H7R84_RS01360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R84_RS01370	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R84_RS01380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R84_RS01395	COG1770	oligopeptidase
H7R84_RS01410	COG4221	oxidoreductase activity
H7R84_RS01415	COG0583	DNA-binding transcription factor activity
H7R84_RS01420	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R84_RS01445	COG0742	ribosomal rna small subunit methyltransferase
H7R84_RS01450	COG0552	protein localization to endoplasmic reticulum
H7R84_RS01455	COG2884	Cell division ATP-binding protein ftsE
H7R84_RS01460	COG2177	Part of the ABC transporter FtsEX involved in
H7R84_RS01470	COG0288	reversible hydration of carbon dioxide
H7R84_RS01475	COG2188	Transcriptional regulator
H7R84_RS01480	COG1228	amidohydrolase
H7R84_RS01485	COG0010	Belongs to the arginase family
H7R84_RS01490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7R84_RS01495	COG2986	histidine ammonia-lyase
H7R84_RS01500	COG0387	Pfam Sodium calcium exchanger
H7R84_RS01505	COG2200	EAL domain
H7R84_RS01510	COG2200	EAL domain
H7R84_RS01510	COG2199	diguanylate cyclase activity
H7R84_RS01560	COG3941	tape measure
H7R84_RS01565	COG4397	Mu-like prophage major head subunit gpT
H7R84_RS01615	COG1459	type II secretion system
H7R84_RS01630	COG2165	general secretion pathway protein
H7R84_RS01635	COG4968	Prepilin-type N-terminal cleavage methylation domain
H7R84_RS01660	COG1077	Cell shape determining protein MreB Mrl
H7R84_RS01665	COG1792	Involved in formation and maintenance of cell shape
H7R84_RS01670	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7R84_RS01675	COG0424	maF-like protein
H7R84_RS01680	COG1530	ribonuclease E activity
H7R84_RS01685	COG3164	Protein of unknown function
H7R84_RS01695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R84_RS01700	COG0312	modulator of DNA gyrase
H7R84_RS01720	COG0477	Major facilitator Superfamily
H7R84_RS01765	COG0189	ligase activity
H7R84_RS01770	COG0642	Histidine kinase
H7R84_RS01775	COG0745	RESPONSE REGULATOR receiver
H7R84_RS01790	COG0789	Transcriptional regulator
H7R84_RS01795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7R84_RS01800	COG0352	thiamine-phosphate diphosphorylase activity
H7R84_RS01805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R84_RS01815	COG2022	thiamine diphosphate biosynthetic process
H7R84_RS01820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R84_RS01830	COG0110	maltose O-acetyltransferase activity
H7R84_RS01845	COG0814	amino acid
H7R84_RS01850	COG3932	Exopolysaccharide synthesis, ExoD
H7R84_RS01860	COG3706	GGDEF domain
H7R84_RS01870	COG0004	ammonium transporteR
H7R84_RS01875	COG3133	Outer membrane lipoprotein
H7R84_RS01880	COG0456	acetyltransferase
H7R84_RS01900	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7R84_RS01905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7R84_RS01920	COG0671	phosphoesterase, PA-phosphatase related
H7R84_RS01925	COG0628	permease
H7R84_RS01940	COG2957	Belongs to the agmatine deiminase family
H7R84_RS01945	COG0583	DNA-binding transcription factor activity
H7R84_RS01965	COG3284	Transcriptional regulator
H7R84_RS01975	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H7R84_RS01975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R84_RS01975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7R84_RS01980	COG1461	Dihydroxyacetone kinase
H7R84_RS01985	COG2376	Dihydroxyacetone kinase
H7R84_RS01990	COG2252	PERMEase
H7R84_RS01995	COG1278	Cold shock
H7R84_RS02005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7R84_RS02020	COG2197	response regulator
H7R84_RS02055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7R84_RS02065	COG3047	cAMP biosynthetic process
H7R84_RS02070	COG3385	transposase activity
H7R84_RS02075	COG0840	transmembrane signaling receptor activity
H7R84_RS02100	COG3135	benzoate transporter
H7R84_RS02105	COG1396	sequence-specific DNA binding
H7R84_RS02140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R84_RS02140	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R84_RS02155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7R84_RS02160	COG0038	chloride channel
H7R84_RS02170	COG0316	Belongs to the HesB IscA family
H7R84_RS02175	COG1757	Na H antiporter
H7R84_RS02215	COG0297	glycogen (starch) synthase activity
H7R84_RS02220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7R84_RS02225	COG2813	Specifically methylates the guanine in position
H7R84_RS02230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R84_RS02240	COG1392	Phosphate transport regulator
H7R84_RS02245	COG0306	phosphate transporter
H7R84_RS02250	COG0527	aspartate kinase activity
H7R84_RS02250	COG0460	homoserine dehydrogenase
H7R84_RS02255	COG0626	cystathionine gamma-synthase activity
H7R84_RS02265	COG0814	amino acid
H7R84_RS02275	COG1218	3'(2'),5'-bisphosphate nucleotidase
H7R84_RS02280	COG0494	nUDIX hydrolase
H7R84_RS02285	COG1011	Hydrolase
H7R84_RS02300	COG0110	maltose O-acetyltransferase activity
H7R84_RS02305	COG3174	membrane
H7R84_RS02310	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7R84_RS02320	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7R84_RS02325	COG4208	sulfate ABC transporter
H7R84_RS02330	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7R84_RS02335	COG0583	DNA-binding transcription factor activity
H7R84_RS02340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7R84_RS02345	COG0765	amino acid transport
H7R84_RS02355	COG1126	abc transporter atp-binding protein
H7R84_RS02360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R84_RS02365	COG3397	chitin binding
H7R84_RS02370	COG0840	transmembrane signaling receptor activity
H7R84_RS02400	COG0543	2 iron, 2 sulfur cluster binding
H7R84_RS02400	COG0633	Ferredoxin
H7R84_RS02415	COG1328	CTP reductase activity
H7R84_RS02420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R84_RS02435	COG1448	Aminotransferase
H7R84_RS02455	COG1215	transferase activity, transferring glycosyl groups
H7R84_RS02465	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H7R84_RS02470	COG3118	belongs to the thioredoxin family
H7R84_RS02470	COG0457	Tetratricopeptide repeat
H7R84_RS02505	COG3385	transposase activity
H7R84_RS02515	COG0513	Belongs to the DEAD box helicase family
H7R84_RS02540	COG3112	Uncharacterised protein family (UPF0231)
H7R84_RS02550	COG3835	regulator
H7R84_RS02555	COG2610	gluconate transmembrane transporter activity
H7R84_RS02560	COG1929	Belongs to the glycerate kinase type-1 family
H7R84_RS02580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R84_RS02590	COG1872	DUF167
H7R84_RS02595	COG0762	integral membrane protein
H7R84_RS02600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7R84_RS02605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7R84_RS02620	COG3022	response to hydroperoxide
H7R84_RS02640	COG0347	Belongs to the P(II) protein family
H7R84_RS02645	COG1840	ABC-type Fe3 transport system, periplasmic component
H7R84_RS02655	COG3842	ATPase activity
H7R84_RS02660	COG2837	iron assimilation
H7R84_RS02665	COG1438	arginine binding
H7R84_RS02670	COG1126	abc transporter atp-binding protein
H7R84_RS02675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R84_RS02680	COG4215	(ABC) transporter
H7R84_RS02685	COG4160	amino acid transport
H7R84_RS02690	COG0039	L-malate dehydrogenase activity
H7R84_RS02695	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H7R84_RS02700	COG1017	nitric oxide dioxygenase activity
H7R84_RS02700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R84_RS02710	COG4536	flavin adenine dinucleotide binding
H7R84_RS02715	COG4137	Cytochrome C assembly protein
H7R84_RS02720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7R84_RS02725	COG0228	four-way junction DNA binding
H7R84_RS02730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7R84_RS02735	COG0336	Belongs to the RNA methyltransferase TrmD family
H7R84_RS02740	COG0335	large ribosomal subunit rRNA binding
H7R84_RS02750	COG3066	DNA modification
H7R84_RS02755	COG1051	belongs to the nudix hydrolase family
H7R84_RS02765	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7R84_RS02770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7R84_RS02775	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R84_RS02785	COG0583	DNA-binding transcription factor activity
H7R84_RS02790	COG0640	Transcriptional regulator
H7R84_RS02795	COG0268	Binds directly to 16S ribosomal RNA
H7R84_RS02800	COG0728	peptidoglycan biosynthetic process
H7R84_RS02805	COG0196	riboflavin kinase activity
H7R84_RS02810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7R84_RS02815	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7R84_RS02820	COG1047	Peptidyl-prolyl cis-trans
H7R84_RS02825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7R84_RS02835	COG3039	Transposase
H7R84_RS02880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7R84_RS02880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R84_RS02895	COG1854	S-ribosylhomocysteine lyase activity
H7R84_RS02900	COG2165	general secretion pathway protein
H7R84_RS02905	COG0084	hydrolase, TatD family'
H7R84_RS02910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R84_RS02920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7R84_RS02925	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7R84_RS02930	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H7R84_RS02950	COG0560	Phosphoserine phosphatase
H7R84_RS02965	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H7R84_RS02970	COG3385	transposase activity
H7R84_RS02985	COG0776	regulation of translation
H7R84_RS02995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7R84_RS03000	COG1914	H( )-stimulated, divalent metal cation uptake system
H7R84_RS03005	COG0360	Binds together with S18 to 16S ribosomal RNA
H7R84_RS03010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7R84_RS03015	COG0359	binds to the 23S rRNA
H7R84_RS03020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R84_RS03040	COG1064	alcohol dehydrogenase
H7R84_RS03045	COG1238	metal cluster binding
H7R84_RS03050	COG0612	Peptidase, M16
H7R84_RS03055	COG2918	glutathione biosynthetic process
H7R84_RS03065	COG3385	transposase activity
H7R84_RS03070	COG1022	Amp-dependent synthetase and ligase
H7R84_RS03080	COG0456	acetyltransferase
H7R84_RS03105	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H7R84_RS03125	COG0477	Major facilitator Superfamily
H7R84_RS03130	COG0583	DNA-binding transcription factor activity
H7R84_RS03135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R84_RS03140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R84_RS03150	COG0673	inositol 2-dehydrogenase activity
H7R84_RS03160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7R84_RS03165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7R84_RS03170	COG3036	rescue of stalled ribosome
H7R84_RS03180	COG0138	bifunctional purine biosynthesis protein purh
H7R84_RS03185	COG0151	Belongs to the GarS family
H7R84_RS03250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7R84_RS03255	COG0358	DNA primase activity
H7R84_RS03260	COG1610	YqeY-like protein
H7R84_RS03265	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7R84_RS03270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7R84_RS03275	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R84_RS03280	COG1027	Aspartate ammonia-lyase
H7R84_RS03285	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7R84_RS03290	COG0534	Mate efflux family protein
H7R84_RS03295	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7R84_RS03300	COG0459	protein refolding
H7R84_RS03360	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7R84_RS03365	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H7R84_RS03375	COG4143	(ABC) transporter
H7R84_RS03390	COG0066	3-isopropylmalate dehydratase activity
H7R84_RS03395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7R84_RS03400	COG0473	3-isopropylmalate dehydrogenase activity
H7R84_RS03405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7R84_RS03415	COG0671	phosphoesterase, PA-phosphatase related
H7R84_RS03430	COG0028	Belongs to the TPP enzyme family
H7R84_RS03435	COG0440	acetolactate synthase activity
H7R84_RS03485	COG3311	Transcriptional regulator
H7R84_RS03575	COG2003	Belongs to the UPF0758 family
H7R84_RS03630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R84_RS03645	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H7R84_RS03655	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7R84_RS03670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R84_RS03700	COG0745	RESPONSE REGULATOR receiver
H7R84_RS03705	COG3104	oligopeptide transport
H7R84_RS03710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7R84_RS03715	COG1555	photosystem II stabilization
H7R84_RS03720	COG0280	phosphate acetyltransferase
H7R84_RS03720	COG0857	belongs to the CobB CobQ family
H7R84_RS03725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R84_RS03735	COG3013	Belongs to the UPF0304 family
H7R84_RS03740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7R84_RS03745	COG2716	regulation of RNA biosynthetic process
H7R84_RS03750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R84_RS03755	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H7R84_RS03760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7R84_RS03795	COG2198	Histidine kinase
H7R84_RS03795	COG0784	Response regulator, receiver
H7R84_RS03795	COG5002	protein histidine kinase activity
H7R84_RS03800	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H7R84_RS03810	COG0784	Response regulator, receiver
H7R84_RS03810	COG5002	protein histidine kinase activity
H7R84_RS03810	COG2205	protein histidine kinase activity
H7R84_RS03830	COG1464	Belongs to the NlpA lipoprotein family
H7R84_RS03835	COG2011	ABC-type metal ion transport system permease component
H7R84_RS03860	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7R84_RS03860	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7R84_RS03865	COG0802	atpase or kinase
H7R84_RS03875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7R84_RS03880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7R84_RS03885	COG1923	regulation of RNA biosynthetic process
H7R84_RS03890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7R84_RS03895	COG0330	HflC and HflK could
H7R84_RS03900	COG0330	HflC and HflK could
H7R84_RS03905	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H7R84_RS03915	COG0142	geranyltranstransferase activity
H7R84_RS03920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7R84_RS03925	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7R84_RS03930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7R84_RS03935	COG3314	Sporulation integral membrane protein YlbJ
H7R84_RS03940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7R84_RS03950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7R84_RS03955	COG2967	ApaG domain
H7R84_RS03960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7R84_RS03965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7R84_RS03970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R84_RS03975	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7R84_RS03980	COG3178	'Phosphotransferase
H7R84_RS03985	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7R84_RS03990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R84_RS03995	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R84_RS04020	COG0840	transmembrane signaling receptor activity
H7R84_RS04040	COG1136	(ABC) transporter
H7R84_RS04055	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H7R84_RS04070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7R84_RS04075	COG0784	Response regulator, receiver
H7R84_RS04075	COG3437	response regulator, receiver
H7R84_RS04080	COG0583	DNA-binding transcription factor activity
H7R84_RS04085	COG2076	Multidrug Resistance protein
H7R84_RS04090	COG2076	Multidrug Resistance protein
H7R84_RS04095	COG0346	lactoylglutathione lyase activity
H7R84_RS04100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R84_RS04105	COG1643	Atp-dependent helicase
H7R84_RS04115	COG1489	DNA binding
H7R84_RS04120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7R84_RS04125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R84_RS04130	COG0617	tRNA 3'-terminal CCA addition
H7R84_RS04135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7R84_RS04140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7R84_RS04145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7R84_RS04155	COG1823	symporter activity
H7R84_RS04170	COG1486	melibiose metabolic process
H7R84_RS04180	COG1129	ABC transporter
H7R84_RS04195	COG1924	4 iron, 4 sulfur cluster binding
H7R84_RS04200	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
H7R84_RS04205	COG0842	Transport permease protein
H7R84_RS04210	COG1131	(ABC) transporter
H7R84_RS04225	COG0163	prenyltransferase activity
H7R84_RS04230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R84_RS04235	COG0671	phosphoesterase, PA-phosphatase related
H7R84_RS04240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R84_RS04245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R84_RS04250	COG1151	hydroxylamine reductase activity
H7R84_RS04255	COG0783	Belongs to the Dps family
H7R84_RS04260	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7R84_RS04265	COG4807	Protein conserved in bacteria
H7R84_RS04275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R84_RS04280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R84_RS04285	COG3956	TIGRFAM MazG family protein
H7R84_RS04290	COG0504	CTP synthase activity
H7R84_RS04295	COG0148	phosphopyruvate hydratase activity
H7R84_RS04335	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7R84_RS04345	COG0488	(ABC) transporter
H7R84_RS04365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R84_RS04380	COG1794	racemase activity, acting on amino acids and derivatives
H7R84_RS04390	COG2731	YhcH YjgK YiaL family protein
H7R84_RS04400	COG0668	transmembrane transport
H7R84_RS04405	COG1376	ErfK ybiS ycfS ynhG family protein
H7R84_RS04415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R84_RS04420	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7R84_RS04425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7R84_RS04435	COG0585	pseudouridine synthase activity
H7R84_RS04440	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7R84_RS04445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7R84_RS04450	COG1238	metal cluster binding
H7R84_RS04465	COG1902	pentaerythritol trinitrate reductase activity
H7R84_RS04480	COG2957	Belongs to the agmatine deiminase family
H7R84_RS04485	COG0154	amidase activity
H7R84_RS04510	COG0513	Belongs to the DEAD box helicase family
H7R84_RS04515	COG2199	diguanylate cyclase activity
H7R84_RS04515	COG2203	Gaf domain
H7R84_RS04525	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
H7R84_RS04530	COG1858	cytochrome C peroxidase
H7R84_RS04595	COG2188	Transcriptional regulator
H7R84_RS04610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7R84_RS04620	COG4608	Belongs to the ABC transporter superfamily
H7R84_RS04625	COG0444	Belongs to the ABC transporter superfamily
H7R84_RS04635	COG4239	(ABC) transporter, permease
H7R84_RS04640	COG4174	ABC transporter (Permease)
H7R84_RS04655	COG0811	peptide transport
H7R84_RS04660	COG0811	peptide transport
H7R84_RS04665	COG0848	biopolymer transport protein
H7R84_RS04685	COG0616	signal peptide processing
H7R84_RS04690	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R84_RS04690	COG1902	pentaerythritol trinitrate reductase activity
H7R84_RS04695	COG0778	Nitroreductase
H7R84_RS04705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R84_RS04710	COG2264	protein methyltransferase activity
H7R84_RS04715	COG0604	alcohol dehydrogenase
H7R84_RS04720	COG0583	DNA-binding transcription factor activity
H7R84_RS04725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R84_RS04725	COG1263	PTS System
H7R84_RS04725	COG2190	(PTS) system
H7R84_RS04730	COG4145	pantothenate transmembrane transporter activity
H7R84_RS04735	COG3924	membrane
H7R84_RS04740	COG0439	Biotin carboxylase
H7R84_RS04745	COG0511	ligase activity, forming carbon-carbon bonds
H7R84_RS04750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7R84_RS04755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R84_RS04785	COG3381	protein complex oligomerization
H7R84_RS04795	COG3005	denitrification pathway
H7R84_RS04800	COG0745	RESPONSE REGULATOR receiver
H7R84_RS04810	COG1879	ABC-type sugar transport system periplasmic component
H7R84_RS04815	COG0784	Response regulator, receiver
H7R84_RS04815	COG2205	protein histidine kinase activity
H7R84_RS04815	COG2198	Histidine kinase
H7R84_RS04825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7R84_RS04830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7R84_RS04835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R84_RS04835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R84_RS04850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7R84_RS04855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R84_RS04860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7R84_RS04865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7R84_RS04880	COG0601	transmembrane transport
H7R84_RS04890	COG2900	Belongs to the SlyX family
H7R84_RS04900	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R84_RS04905	COG2204	response regulator
H7R84_RS04925	COG0737	Belongs to the 5'-nucleotidase family
H7R84_RS04945	COG3655	Transcriptional regulator
H7R84_RS04955	COG2205	protein histidine kinase activity
H7R84_RS04955	COG5002	protein histidine kinase activity
H7R84_RS04955	COG0784	Response regulator, receiver
H7R84_RS04965	COG3706	GGDEF domain
H7R84_RS04975	COG3397	chitin binding
H7R84_RS05015	COG0784	Response regulator, receiver
H7R84_RS05015	COG0835	chemotaxis
H7R84_RS05020	COG2755	lipolytic protein G-D-S-L family
H7R84_RS05025	COG4181	ATPase activity
H7R84_RS05030	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H7R84_RS05035	COG1090	epimerase
H7R84_RS05040	COG2200	EAL domain
H7R84_RS05045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R84_RS05050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7R84_RS05055	COG3171	Protein conserved in bacteria
H7R84_RS05060	COG2066	Belongs to the glutaminase family
H7R84_RS05065	COG2897	thiosulfate sulfurtransferase activity
H7R84_RS05080	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R84_RS05090	COG2966	Psort location CytoplasmicMembrane, score
H7R84_RS05105	COG4175	Glycine betaine
H7R84_RS05110	COG4176	ABC-type proline glycine betaine transport system permease component
H7R84_RS05115	COG2113	Glycine betaine
H7R84_RS05130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R84_RS05140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7R84_RS05155	COG5001	Diguanylate cyclase
H7R84_RS05160	COG0786	glutamate:sodium symporter activity
H7R84_RS05165	COG0252	asparaginase activity
H7R84_RS05170	COG3139	Protein of unknown function (DUF1315)
H7R84_RS05190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7R84_RS05195	COG0321	lipoyl(octanoyl) transferase activity
H7R84_RS05200	COG2921	Belongs to the UPF0250 family
H7R84_RS05205	COG1686	Belongs to the peptidase S11 family
H7R84_RS05210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7R84_RS05215	COG2951	lytic endotransglycosylase activity
H7R84_RS05220	COG0772	Belongs to the SEDS family
H7R84_RS05225	COG0772	Belongs to the SEDS family
H7R84_RS05230	COG0768	penicillin binding
H7R84_RS05235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7R84_RS05240	COG0799	negative regulation of ribosome biogenesis
H7R84_RS05245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7R84_RS05260	COG0495	leucyl-tRNA aminoacylation
H7R84_RS05265	COG2888	peptidyl-tyrosine sulfation
H7R84_RS05270	COG0312	modulator of DNA gyrase
H7R84_RS05280	COG0716	FMN binding
H7R84_RS05285	COG4974	Belongs to the 'phage' integrase family
H7R84_RS05290	COG1970	mechanosensitive ion channel activity
H7R84_RS05305	COG0789	Transcriptional regulator
H7R84_RS05310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7R84_RS05315	COG4535	Mg2 and Co2 transporter CorC
H7R84_RS05320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7R84_RS05325	COG1702	phosphate starvation-inducible protein PhoH
H7R84_RS05330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R84_RS05335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R84_RS05340	COG1335	isochorismatase
H7R84_RS05350	COG3706	GGDEF domain
H7R84_RS05355	COG0583	DNA-binding transcription factor activity
H7R84_RS05385	COG1611	Belongs to the LOG family
H7R84_RS05400	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R84_RS05400	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R84_RS05410	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H7R84_RS05435	COG3098	single-species biofilm formation
H7R84_RS05440	COG0564	pseudouridine synthase activity
H7R84_RS05445	COG0716	FMN binding
H7R84_RS05460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R84_RS05460	COG1263	PTS System
H7R84_RS05470	COG2171	N-acyltransferase activity
H7R84_RS05475	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H7R84_RS05480	COG0024	Methionine aminopeptidase
H7R84_RS05485	COG0052	Belongs to the universal ribosomal protein uS2 family
H7R84_RS05490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7R84_RS05495	COG0528	UMP kinase activity
H7R84_RS05500	COG0233	cytoplasmic translational termination
H7R84_RS05505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7R84_RS05510	COG0575	Belongs to the CDS family
H7R84_RS05515	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7R84_RS05520	COG0750	zinc metalloprotease
H7R84_RS05535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R84_RS05540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R84_RS05545	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R84_RS05550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R84_RS05555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7R84_RS05565	COG0825	malonyl-CoA metabolic process
H7R84_RS05580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R84_RS05585	COG1115	amino acid carrier protein
H7R84_RS05600	COG0714	Associated with various cellular activities
H7R84_RS05630	COG3039	Transposase
H7R84_RS05645	COG3104	oligopeptide transport
H7R84_RS05650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7R84_RS05655	COG1678	Uncharacterized ACR, COG1678
H7R84_RS05695	COG1846	Transcriptional regulator
H7R84_RS05710	COG0281	malic enzyme
H7R84_RS05715	COG3290	protein histidine kinase activity
H7R84_RS05725	COG0697	spore germination
H7R84_RS05735	COG0346	lactoylglutathione lyase activity
H7R84_RS05740	COG0745	RESPONSE REGULATOR receiver
H7R84_RS05745	COG5002	protein histidine kinase activity
H7R84_RS05770	COG3142	Participates in the control of copper homeostasis
H7R84_RS05785	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R84_RS05810	COG0678	peroxiredoxin activity
H7R84_RS05820	COG0019	diaminopimelate decarboxylase activity
H7R84_RS05825	COG1115	amino acid carrier protein
H7R84_RS05835	COG0095	Lipoate-protein ligase
H7R84_RS05845	COG2233	PERMEase
H7R84_RS05860	COG0534	Mate efflux family protein
H7R84_RS05870	COG0281	malic enzyme
H7R84_RS05900	COG0733	neurotransmitter:sodium symporter activity
H7R84_RS05905	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R84_RS05910	COG3706	GGDEF domain
H7R84_RS05915	COG1566	PFAM secretion protein HlyD family protein
H7R84_RS05925	COG1032	radical SAM domain protein
H7R84_RS05940	COG3039	Transposase
H7R84_RS05965	COG0673	inositol 2-dehydrogenase activity
H7R84_RS05970	COG2920	part of a sulfur-relay system
H7R84_RS05975	COG1289	transmembrane transporter activity
H7R84_RS05980	COG0670	Belongs to the BI1 family
H7R84_RS06000	COG1486	melibiose metabolic process
H7R84_RS06005	COG1917	Cupin 2, conserved barrel domain protein
H7R84_RS06005	COG2169	Transcriptional regulator
H7R84_RS06010	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7R84_RS06015	COG2723	6-phospho-beta-galactosidase activity
H7R84_RS06020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7R84_RS06025	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7R84_RS06030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7R84_RS06035	COG1446	asparaginase
H7R84_RS06045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7R84_RS06050	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7R84_RS06055	COG3385	transposase activity
H7R84_RS06070	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H7R84_RS06080	COG3156	type II secretion system protein K
H7R84_RS06085	COG4795	General secretion pathway protein
H7R84_RS06090	COG2165	general secretion pathway protein
H7R84_RS06105	COG2165	general secretion pathway protein
H7R84_RS06110	COG1459	type II secretion system
H7R84_RS06115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R84_RS06125	COG3031	protein transport across the cell outer membrane
H7R84_RS06135	COG3409	Peptidoglycan-binding domain 1 protein
H7R84_RS06135	COG3267	Type II secretory pathway component ExeA
H7R84_RS06140	COG2770	Histidine kinase
H7R84_RS06140	COG3437	response regulator, receiver
H7R84_RS06155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7R84_RS06160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7R84_RS06165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R84_RS06175	COG2190	(PTS) system
H7R84_RS06180	COG3706	GGDEF domain
H7R84_RS06190	COG1196	nuclear chromosome segregation
H7R84_RS06190	COG3264	Mechanosensitive ion channel
H7R84_RS06195	COG0469	pyruvate kinase activity
H7R84_RS06205	COG3384	dioxygenase
H7R84_RS06210	COG0419	ATPase involved in DNA repair
H7R84_RS06215	COG0420	3'-5' exonuclease activity
H7R84_RS06225	COG2974	May be involved in recombination
H7R84_RS06235	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7R84_RS06245	COG0531	amino acid
H7R84_RS06250	COG0531	amino acid
H7R84_RS06265	COG1917	Cupin 2, conserved barrel domain protein
H7R84_RS06265	COG1396	sequence-specific DNA binding
H7R84_RS06270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R84_RS06315	COG3038	cytochrome b561
H7R84_RS06325	COG1720	tRNA m6t6A37 methyltransferase activity
H7R84_RS06345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7R84_RS06350	COG4988	ABC transporter
H7R84_RS06365	COG0745	RESPONSE REGULATOR receiver
H7R84_RS06375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R84_RS06405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R84_RS06410	COG1988	membrane-bound metal-dependent
H7R84_RS06430	COG3385	transposase activity
H7R84_RS06435	COG0159	tryptophan synthase activity
H7R84_RS06440	COG0133	tryptophan synthase activity
H7R84_RS06445	COG0135	phosphoribosylanthranilate isomerase activity
H7R84_RS06445	COG0134	indole-3-glycerol-phosphate synthase activity
H7R84_RS06450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R84_RS06455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R84_RS06455	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R84_RS06460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7R84_RS06470	COG0009	L-threonylcarbamoyladenylate synthase
H7R84_RS06480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7R84_RS06490	COG1946	Acyl-CoA thioesterase
H7R84_RS06495	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H7R84_RS06500	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7R84_RS06510	COG0083	homoserine kinase activity
H7R84_RS06515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7R84_RS06520	COG3039	Transposase
H7R84_RS06525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R84_RS06540	COG3385	transposase activity
H7R84_RS06545	COG2850	peptidyl-arginine hydroxylation
H7R84_RS06550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7R84_RS06555	COG2915	High frequency lysogenization protein hflD homolog
H7R84_RS06560	COG0482	sulfurtransferase activity
H7R84_RS06570	COG1187	pseudouridine synthase activity
H7R84_RS06580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R84_RS06600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R84_RS06600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R84_RS06600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R84_RS06605	COG0737	Belongs to the 5'-nucleotidase family
H7R84_RS06640	COG1609	Transcriptional regulator
H7R84_RS06645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R84_RS06645	COG1263	PTS System
H7R84_RS06650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7R84_RS06655	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7R84_RS06665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R84_RS06670	COG1960	acyl-CoA dehydrogenase activity
H7R84_RS06680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7R84_RS06705	COG3383	formate dehydrogenase (NAD+) activity
H7R84_RS06715	COG2205	protein histidine kinase activity
H7R84_RS06715	COG0784	Response regulator, receiver
H7R84_RS06720	COG0514	ATP-dependent DNA helicase (RecQ)
H7R84_RS06725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7R84_RS06745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7R84_RS06750	COG2867	negative regulation of translational initiation
H7R84_RS06755	COG2914	Belongs to the UPF0125 (RnfH) family
H7R84_RS06760	COG1473	amidohydrolase
H7R84_RS06765	COG1960	acyl-CoA dehydrogenase activity
H7R84_RS06770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R84_RS06775	COG0121	glutamine amidotransferase
H7R84_RS06805	COG2197	response regulator
H7R84_RS06810	COG3850	Histidine kinase
H7R84_RS06815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7R84_RS06820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R84_RS06830	COG0243	molybdopterin cofactor binding
H7R84_RS06835	COG0437	4 iron, 4 sulfur cluster binding
H7R84_RS06840	COG0348	domain, Protein
H7R84_RS06850	COG3005	denitrification pathway
H7R84_RS06855	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R84_RS06860	COG0315	cyclic pyranopterin monophosphate synthase activity
H7R84_RS06865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7R84_RS06870	COG0314	molybdopterin synthase activity
H7R84_RS06885	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7R84_RS06890	COG2267	carboxylic ester hydrolase activity
H7R84_RS06895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R84_RS06905	COG0302	gtp cyclohydrolase
H7R84_RS06910	COG0840	transmembrane signaling receptor activity
H7R84_RS06915	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H7R84_RS06925	COG0583	DNA-binding transcription factor activity
H7R84_RS06930	COG2353	YceI-like domain
H7R84_RS06940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7R84_RS06955	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R84_RS06960	COG1166	arginine decarboxylase activity
H7R84_RS06980	COG0814	amino acid
H7R84_RS06985	COG0251	oxidation-reduction process
H7R84_RS06990	COG3681	Belongs to the UPF0597 family
H7R84_RS06995	COG2964	Protein conserved in bacteria
H7R84_RS07015	COG1879	ABC-type sugar transport system periplasmic component
H7R84_RS07020	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7R84_RS07025	COG1288	antiporter activity
H7R84_RS07030	COG0436	Aminotransferase
H7R84_RS07040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R84_RS07045	COG1196	nuclear chromosome segregation
H7R84_RS07045	COG0741	lytic transglycosylase activity
H7R84_RS07045	COG0739	heme binding
H7R84_RS07060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R84_RS07070	COG0788	formyltetrahydrofolate deformylase activity
H7R84_RS07075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R84_RS07095	COG0791	NLP P60 protein
H7R84_RS07105	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H7R84_RS07115	COG0471	metal ion transport
H7R84_RS07125	COG1376	ErfK ybiS ycfS ynhG family protein
H7R84_RS07125	COG1388	LysM domain
H7R84_RS07135	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7R84_RS07140	COG1085	galactose-1-phosphate uridylyltransferase
H7R84_RS07145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R84_RS07150	COG1609	Transcriptional regulator
H7R84_RS07155	COG4580	involved in the transport of maltose and maltodextrins
H7R84_RS07195	COG2182	Extracellular solute-binding protein
H7R84_RS07200	COG1175	transmembrane transport
H7R84_RS07205	COG3833	ABC-type maltose transport systems, permease component
H7R84_RS07210	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H7R84_RS07215	COG1874	Beta-galactosidase
H7R84_RS07220	COG1263	PTS System
H7R84_RS07220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R84_RS07220	COG2190	(PTS) system
H7R84_RS07225	COG0469	pyruvate kinase activity
H7R84_RS07250	COG1388	LysM domain
H7R84_RS07250	COG0741	lytic transglycosylase activity
H7R84_RS07255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R84_RS07260	COG2226	methyltransferase
H7R84_RS07265	COG0328	RNA-DNA hybrid ribonuclease activity
H7R84_RS07270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R84_RS07280	COG0784	Response regulator, receiver
H7R84_RS07280	COG3437	response regulator, receiver
H7R84_RS07285	COG2375	cellular response to nickel ion
H7R84_RS07290	COG4771	TonB-dependent receptor
H7R84_RS07295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R84_RS07300	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R84_RS07305	COG1120	ATPase activity
H7R84_RS07310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R84_RS07320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R84_RS07325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R84_RS07355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R84_RS07360	COG1122	ATPase activity
H7R84_RS07385	COG0708	Exodeoxyribonuclease III
H7R84_RS07425	COG3132	Protein of unknown function, DUF480
H7R84_RS07430	COG3300	MHYT domain
H7R84_RS07430	COG5001	Diguanylate cyclase
H7R84_RS07440	COG2841	Protein conserved in bacteria
H7R84_RS07450	COG0534	Mate efflux family protein
H7R84_RS07475	COG1454	alcohol dehydrogenase
H7R84_RS07485	COG1309	transcriptional regulator
H7R84_RS07520	COG3152	Membrane
H7R84_RS07535	COG0589	response to stress
H7R84_RS07540	COG0659	secondary active sulfate transmembrane transporter activity
H7R84_RS07545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R84_RS07565	COG3537	Alpha-1,2-mannosidase
H7R84_RS07575	COG2207	Transcriptional regulator
H7R84_RS07580	COG0538	isocitrate dehydrogenase activity
H7R84_RS07590	COG3048	D-serine ammonia-lyase activity
H7R84_RS07595	COG2610	gluconate transmembrane transporter activity
H7R84_RS07600	COG0583	DNA-binding transcription factor activity
H7R84_RS07610	COG0791	NLP P60 protein
H7R84_RS07615	COG0583	DNA-binding transcription factor activity
H7R84_RS07620	COG0450	alkyl hydroperoxide reductase
H7R84_RS07640	COG0500	methyltransferase
H7R84_RS07645	COG4106	trans-aconitate 2-methyltransferase activity
H7R84_RS07650	COG1801	Protein of unknown function DUF72
H7R84_RS07660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7R84_RS07665	COG0217	transcriptional regulatory protein
H7R84_RS07675	COG1454	alcohol dehydrogenase
H7R84_RS07675	COG1012	belongs to the aldehyde dehydrogenase family
H7R84_RS07680	COG2095	MarC family integral membrane protein
H7R84_RS07690	COG0601	transmembrane transport
H7R84_RS07695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R84_RS07715	COG0861	Integral membrane protein TerC family
H7R84_RS07720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R84_RS07750	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H7R84_RS07755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R84_RS07760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7R84_RS07770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R84_RS07775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7R84_RS07780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7R84_RS07790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7R84_RS07800	COG0505	Belongs to the CarA family
H7R84_RS07805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7R84_RS07835	COG0346	lactoylglutathione lyase activity
H7R84_RS07840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7R84_RS07845	COG4660	Part of a membrane complex involved in electron transport
H7R84_RS07850	COG4659	FMN binding
H7R84_RS07855	COG4658	electron transport chain
H7R84_RS07865	COG2878	Part of a membrane complex involved in electron transport
H7R84_RS07870	COG4657	Part of a membrane complex involved in electron transport
H7R84_RS07875	COG1061	Type III restriction enzyme res subunit
H7R84_RS07885	COG0346	lactoylglutathione lyase activity
H7R84_RS07890	COG1187	pseudouridine synthase activity
H7R84_RS07905	COG0583	DNA-binding transcription factor activity
H7R84_RS07920	COG2979	Protein of unknown function (DUF533)
H7R84_RS07925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R84_RS07935	COG1294	oxidase, subunit
H7R84_RS07955	COG3220	belongs to the UPF0276 family
H7R84_RS07970	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R84_RS07975	COG2814	Major facilitator Superfamily
H7R84_RS07980	COG0656	L-ascorbic acid biosynthetic process
H7R84_RS08000	COG0583	DNA-binding transcription factor activity
H7R84_RS08005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7R84_RS08010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R84_RS08020	COG1349	DNA-binding transcription factor activity
H7R84_RS08030	COG0584	glycerophosphoryl diester phosphodiesterase
H7R84_RS08035	COG4574	serine-type endopeptidase inhibitor activity
H7R84_RS08040	COG3085	chromosome segregation
H7R84_RS08045	COG0583	DNA-binding transcription factor activity
H7R84_RS08055	COG1448	Aminotransferase
H7R84_RS08070	COG2333	competence protein COMEC
H7R84_RS08070	COG0658	competence protein
H7R84_RS08080	COG1663	tetraacyldisaccharide 4'-kinase activity
H7R84_RS08085	COG2835	tetraacyldisaccharide 4'-kinase activity
H7R84_RS08090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7R84_RS08095	COG2197	response regulator
H7R84_RS08100	COG0322	excinuclease ABC activity
H7R84_RS08125	COG3039	Transposase
H7R84_RS08190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R84_RS08200	COG4974	Belongs to the 'phage' integrase family
H7R84_RS08215	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R84_RS08225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R84_RS08280	COG2119	membrane
H7R84_RS08285	COG0023	Translation Initiation Factor
H7R84_RS08310	COG0513	Belongs to the DEAD box helicase family
H7R84_RS08320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R84_RS08325	COG0765	amino acid transport
H7R84_RS08330	COG1126	abc transporter atp-binding protein
H7R84_RS08335	COG0493	'glutamate synthase
H7R84_RS08340	COG0069	glutamate synthase activity
H7R84_RS08340	COG0070	glutamate synthase
H7R84_RS08340	COG0067	glutamate synthase
H7R84_RS08345	COG1242	4 iron, 4 sulfur cluster binding
H7R84_RS08390	COG3634	alkyl hydroperoxide reductase activity
H7R84_RS08400	COG0517	IMP dehydrogenase activity
H7R84_RS08405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7R84_RS08410	COG0343	queuine tRNA-ribosyltransferase activity
H7R84_RS08415	COG1862	Preprotein translocase
H7R84_RS08420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R84_RS08425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R84_RS08430	COG2897	thiosulfate sulfurtransferase activity
H7R84_RS08440	COG0826	peptidase U32
H7R84_RS08445	COG0826	peptidase U32
H7R84_RS08450	COG3154	lipid carrier protein
H7R84_RS08470	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7R84_RS08475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7R84_RS08475	COG0574	Belongs to the PEP-utilizing enzyme family
H7R84_RS08480	COG2207	Transcriptional regulator
H7R84_RS08500	COG1464	Belongs to the NlpA lipoprotein family
H7R84_RS08505	COG3083	sulfuric ester hydrolase activity
H7R84_RS08510	COG3082	Protein of unknown function (DUF1414)
H7R84_RS08515	COG3081	Nucleoid-associated protein
H7R84_RS08525	COG1175	transmembrane transport
H7R84_RS08530	COG3833	ABC-type maltose transport systems, permease component
H7R84_RS08535	COG3842	ATPase activity
H7R84_RS08560	COG0425	Belongs to the sulfur carrier protein TusA family
H7R84_RS08565	COG4783	chaperone-mediated protein folding
H7R84_RS08575	COG1393	Belongs to the ArsC family
H7R84_RS08585	COG3385	transposase activity
H7R84_RS08590	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H7R84_RS08595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R84_RS08600	COG2431	L-lysine efflux transmembrane transporter activity
H7R84_RS08610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R84_RS08620	COG4160	amino acid transport
H7R84_RS08625	COG0564	pseudouridine synthase activity
H7R84_RS08640	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7R84_RS08650	COG0625	glutathione transferase activity
H7R84_RS08660	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R84_RS08665	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R84_RS08670	COG0367	asparagine synthase
H7R84_RS08680	COG4651	solute:proton antiporter activity
H7R84_RS08680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7R84_RS08685	COG0647	UMP catabolic process
H7R84_RS08700	COG1902	pentaerythritol trinitrate reductase activity
H7R84_RS08705	COG1253	flavin adenine dinucleotide binding
H7R84_RS08715	COG0247	lactate metabolic process
H7R84_RS08715	COG0277	FAD linked oxidase domain protein
H7R84_RS08725	COG2050	protein possibly involved in aromatic compounds catabolism
H7R84_RS08730	COG0513	Belongs to the DEAD box helicase family
H7R84_RS08740	COG3300	MHYT domain
H7R84_RS08740	COG5001	Diguanylate cyclase
H7R84_RS08745	COG2056	Na+-H+ antiporter family
H7R84_RS08750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R84_RS08755	COG0671	phosphoesterase, PA-phosphatase related
H7R84_RS08760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R84_RS08765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R84_RS08775	COG0101	tRNA pseudouridine synthase activity
H7R84_RS08780	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7R84_RS08785	COG0285	dihydrofolate synthase activity
H7R84_RS08790	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H7R84_RS08795	COG0393	Putative heavy-metal-binding
H7R84_RS08810	COG4667	esterase of the alpha-beta hydrolase superfamily
H7R84_RS08815	COG1368	sulfuric ester hydrolase activity
H7R84_RS08825	COG0527	aspartate kinase activity
H7R84_RS08830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7R84_RS08830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R84_RS08835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R84_RS08855	COG0596	Alpha beta hydrolase
H7R84_RS08875	COG0577	efflux transmembrane transporter activity
H7R84_RS08880	COG1136	(ABC) transporter
H7R84_RS08895	COG2814	Major facilitator Superfamily
H7R84_RS08915	COG0672	)-iron permease
H7R84_RS08950	COG0659	secondary active sulfate transmembrane transporter activity
H7R84_RS08960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7R84_RS08965	COG0326	Molecular chaperone. Has ATPase activity
H7R84_RS08970	COG4172	Belongs to the ABC transporter superfamily
H7R84_RS08975	COG4172	Belongs to the ABC transporter superfamily
H7R84_RS08985	COG4168	peptide transport system, permease
H7R84_RS08995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7R84_RS09000	COG1842	Phage shock protein A
H7R84_RS09015	COG3106	COG3106 Predicted ATPase
H7R84_RS09020	COG3768	UPF0283 membrane protein
H7R84_RS09025	COG0583	DNA-binding transcription factor activity
H7R84_RS09030	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7R84_RS09035	COG3842	ATPase activity
H7R84_RS09040	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R84_RS09045	COG1177	transmembrane transport
H7R84_RS09050	COG1012	belongs to the aldehyde dehydrogenase family
H7R84_RS09060	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7R84_RS09075	COG2199	diguanylate cyclase activity
H7R84_RS09080	COG2885	chlorophyll binding
H7R84_RS09085	COG0861	Integral membrane protein TerC family
H7R84_RS09100	COG1022	Amp-dependent synthetase and ligase
H7R84_RS09115	COG2910	NAD(P)H-binding
H7R84_RS09120	COG0583	DNA-binding transcription factor activity
H7R84_RS09125	COG0583	DNA-binding transcription factor activity
H7R84_RS09130	COG0583	DNA-binding transcription factor activity
H7R84_RS09135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7R84_RS09145	COG0583	DNA-binding transcription factor activity
H7R84_RS09150	COG2723	6-phospho-beta-galactosidase activity
H7R84_RS09155	COG1944	ATP diphosphatase activity
H7R84_RS09160	COG2116	formate transmembrane transporter activity
H7R84_RS09165	COG1882	Formate acetyltransferase
H7R84_RS09170	COG2983	Belongs to the UPF0260 family
H7R84_RS09180	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7R84_RS09185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7R84_RS09195	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R84_RS09200	COG1136	(ABC) transporter
H7R84_RS09205	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R84_RS09210	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H7R84_RS09220	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7R84_RS09225	COG0740	serine-type endopeptidase activity
H7R84_RS09230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7R84_RS09235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7R84_RS09240	COG0776	regulation of translation
H7R84_RS09245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R84_RS09265	COG0488	(ABC) transporter
H7R84_RS09270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R84_RS09275	COG3162	membrane
H7R84_RS09290	COG1024	Enoyl-CoA hydratase
H7R84_RS09295	COG1115	amino acid carrier protein
H7R84_RS09320	COG1584	GPR1 FUN34 yaaH family protein
H7R84_RS09360	COG1024	Enoyl-CoA hydratase
H7R84_RS09365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7R84_RS09370	COG1960	acyl-CoA dehydrogenase activity
H7R84_RS09375	COG1960	acyl-CoA dehydrogenase activity
H7R84_RS09380	COG1024	Enoyl-CoA hydratase
H7R84_RS09385	COG1024	Enoyl-CoA hydratase
H7R84_RS09395	COG1028	Short-chain dehydrogenase reductase Sdr
H7R84_RS09405	COG0730	response to heat
H7R84_RS09440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7R84_RS09450	COG2003	Belongs to the UPF0758 family
H7R84_RS09500	COG0640	Transcriptional regulator
H7R84_RS09515	COG0798	PFAM Bile acid sodium symporter
H7R84_RS09520	COG1393	Belongs to the ArsC family
H7R84_RS09555	COG1993	acr, cog1993
H7R84_RS09560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7R84_RS09580	COG5001	Diguanylate cyclase
H7R84_RS09580	COG3706	GGDEF domain
H7R84_RS09580	COG2203	Gaf domain
H7R84_RS09580	COG4251	negative regulation of phosphorylation
H7R84_RS09585	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R84_RS09590	COG3437	response regulator, receiver
H7R84_RS09605	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H7R84_RS09610	COG0437	4 iron, 4 sulfur cluster binding
H7R84_RS09615	COG5557	Pfam Polysulphide reductase, NrfD
H7R84_RS09620	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H7R84_RS09625	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7R84_RS09630	COG1773	rubredoxin
H7R84_RS09640	COG0601	transmembrane transport
H7R84_RS09645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R84_RS09655	COG3842	ATPase activity
H7R84_RS09660	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H7R84_RS09665	COG0375	protein maturation
H7R84_RS09670	COG0309	Hydrogenase expression formation protein (HypE)
H7R84_RS09680	COG0298	carbon dioxide binding
H7R84_RS09685	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7R84_RS09695	COG1921	L-seryl-tRNASec selenium transferase activity
H7R84_RS09705	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7R84_RS09715	COG3260	NADH ubiquinone oxidoreductase 20
H7R84_RS09720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R84_RS09725	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H7R84_RS09725	COG3261	NADH dehydrogenase
H7R84_RS09730	COG0650	Formate hydrogenlyase subunit 4
H7R84_RS09735	COG0651	ATP synthesis coupled electron transport
H7R84_RS09740	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R84_RS09745	COG3158	transport of potassium into the cell
H7R84_RS09765	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R84_RS09795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R84_RS09800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R84_RS09805	COG3046	protein related to deoxyribodipyrimidine photolyase
H7R84_RS09815	COG3033	Beta-eliminating lyase
H7R84_RS09820	COG0295	cytidine deaminase activity
H7R84_RS09825	COG1346	cytolysis
H7R84_RS09830	COG1380	Effector of murein hydrolase LrgA
H7R84_RS09835	COG3345	alpha-galactosidase
H7R84_RS09845	COG2925	Exonuclease
H7R84_RS09850	COG0582	viral genome integration into host DNA
H7R84_RS09995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R84_RS10010	COG4416	COG NOG18757 non supervised orthologous group
H7R84_RS10055	COG1802	Transcriptional regulator
H7R84_RS10055	COG4626	Terminase
H7R84_RS10070	COG0616	signal peptide processing
H7R84_RS10110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H7R84_RS10165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7R84_RS10180	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H7R84_RS10215	COG0641	radical SAM
H7R84_RS10245	COG2304	oxidoreductase activity
H7R84_RS10260	COG0714	Associated with various cellular activities
H7R84_RS10265	COG3119	arylsulfatase activity
H7R84_RS10270	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R84_RS10275	COG0517	IMP dehydrogenase activity
H7R84_RS10275	COG0617	tRNA 3'-terminal CCA addition
H7R84_RS10275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7R84_RS10280	COG1643	Atp-dependent helicase
H7R84_RS10290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7R84_RS10305	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7R84_RS10310	COG2067	long-chain fatty acid transport protein
H7R84_RS10315	COG2067	long-chain fatty acid transport protein
H7R84_RS10325	COG1595	DNA-templated transcription, initiation
H7R84_RS10335	COG2304	oxidoreductase activity
H7R84_RS10355	COG0714	Associated with various cellular activities
H7R84_RS10360	COG0183	Belongs to the thiolase family
H7R84_RS10365	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R84_RS10365	COG1024	Enoyl-CoA hydratase
H7R84_RS10370	COG2719	SpoVR family
H7R84_RS10375	COG2718	Belongs to the UPF0229 family
H7R84_RS10380	COG2766	serine protein kinase
H7R84_RS10385	COG0514	ATP-dependent DNA helicase (RecQ)
H7R84_RS10390	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H7R84_RS10400	COG0814	amino acid
H7R84_RS10405	COG0494	nUDIX hydrolase
H7R84_RS10420	COG2824	Alkylphosphonate utilization operon protein PhnA
H7R84_RS10435	COG3791	Glutathione-dependent formaldehyde-activating
H7R84_RS10440	COG0406	alpha-ribazole phosphatase activity
H7R84_RS10445	COG3706	GGDEF domain
H7R84_RS10450	COG2840	Smr protein MutS2
H7R84_RS10455	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R84_RS10460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7R84_RS10470	COG0513	Belongs to the DEAD box helicase family
H7R84_RS10475	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H7R84_RS10480	COG0814	amino acid
H7R84_RS10485	COG1609	Transcriptional regulator
H7R84_RS10490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R84_RS10490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R84_RS10495	COG1105	Belongs to the carbohydrate kinase PfkB family
H7R84_RS10500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R84_RS10500	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H7R84_RS10500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R84_RS10505	COG3313	Fe-S protein
H7R84_RS10510	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H7R84_RS10515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R84_RS10520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R84_RS10525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R84_RS10535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R84_RS10545	COG3385	transposase activity
H7R84_RS10550	COG0366	Alpha amylase catalytic
H7R84_RS10570	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7R84_RS10575	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7R84_RS10580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7R84_RS10585	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7R84_RS10590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7R84_RS10595	COG0072	phenylalanine-tRNA ligase activity
H7R84_RS10595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R84_RS10600	COG0776	regulation of translation
H7R84_RS10605	COG2205	protein histidine kinase activity
H7R84_RS10605	COG0784	Response regulator, receiver
H7R84_RS10625	COG1609	Transcriptional regulator
H7R84_RS10630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R84_RS10635	COG1879	ABC-type sugar transport system periplasmic component
H7R84_RS10640	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7R84_RS10645	COG1129	ABC transporter
H7R84_RS10650	COG1869	D-ribose catabolic process
H7R84_RS10655	COG0625	glutathione transferase activity
H7R84_RS10670	COG1177	transmembrane transport
H7R84_RS10685	COG3423	Transcriptional regulator
H7R84_RS10690	COG2801	Transposase and inactivated derivatives
H7R84_RS10800	COG0640	Transcriptional regulator
H7R84_RS10815	COG4373	Mu-like prophage FluMu protein gp28
H7R84_RS10820	COG4383	Mu-like prophage protein gp29
H7R84_RS10835	COG4397	Mu-like prophage major head subunit gpT
H7R84_RS10875	COG4386	tail sheath protein
H7R84_RS10885	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
H7R84_RS10905	COG4384	Bacteriophage Mu Gp45 protein
H7R84_RS10915	COG3299	homolog of phage Mu protein gp47
H7R84_RS10945	COG3385	transposase activity
H7R84_RS10950	COG0037	tRNA processing
H7R84_RS10955	COG0589	response to stress
H7R84_RS10960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R84_RS10975	COG2217	Heavy metal translocating P-type atpase
H7R84_RS10985	COG2010	Cytochrome c
H7R84_RS11000	COG3278	Belongs to the heme-copper respiratory oxidase family
H7R84_RS11010	COG1956	GAF domain-containing protein
H7R84_RS11015	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H7R84_RS11025	COG0308	aminopeptidase N
H7R84_RS11035	COG2902	Dehydrogenase
H7R84_RS11040	COG0167	dihydroorotate dehydrogenase activity
H7R84_RS11050	COG0254	rRNA binding
H7R84_RS11055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7R84_RS11060	COG0116	Belongs to the methyltransferase superfamily
H7R84_RS11060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R84_RS11070	COG0488	(ABC) transporter
H7R84_RS11080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R84_RS11085	COG1067	ATP-dependent peptidase activity
H7R84_RS11130	COG4128	Pfam Zonular occludens toxin
H7R84_RS11165	COG3141	response to X-ray
H7R84_RS11170	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7R84_RS11175	COG4221	oxidoreductase activity
H7R84_RS11220	COG0372	Belongs to the citrate synthase family
H7R84_RS11225	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7R84_RS11235	COG2995	paraquat-inducible protein a
H7R84_RS11240	COG3008	intermembrane lipid transfer
H7R84_RS11245	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H7R84_RS11245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R84_RS11260	COG0084	hydrolase, TatD family'
H7R84_RS11265	COG0470	DNA polymerase III
H7R84_RS11270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7R84_RS11275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7R84_RS11280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7R84_RS11290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7R84_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
H7R84_RS11305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R84_RS11310	COG0416	fatty acid biosynthetic process
H7R84_RS11315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7R84_RS11320	COG1399	metal-binding, possibly nucleic acid-binding protein
H7R84_RS11325	COG0424	maF-like protein
H7R84_RS11330	COG0583	DNA-binding transcription factor activity
H7R84_RS11350	COG0546	phosphoglycolate phosphatase activity
H7R84_RS11355	COG0564	pseudouridine synthase activity
H7R84_RS11360	COG1530	ribonuclease E activity
H7R84_RS11365	COG3385	transposase activity
H7R84_RS11385	COG0306	phosphate transporter
H7R84_RS11390	COG0717	Belongs to the dCTP deaminase family
H7R84_RS11395	COG0572	uridine kinase
H7R84_RS11400	COG0489	protein tyrosine kinase activity
H7R84_RS11405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R84_RS11405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R84_RS11415	COG1254	Belongs to the acylphosphatase family
H7R84_RS11420	COG0840	transmembrane signaling receptor activity
H7R84_RS11425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R84_RS11440	COG0709	Synthesizes selenophosphate from selenide and ATP
H7R84_RS11445	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H7R84_RS11450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R84_RS11460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7R84_RS11465	COG3039	Transposase
H7R84_RS11480	COG0318	PFAM AMP-dependent synthetase and ligase
H7R84_RS11485	COG2267	carboxylic ester hydrolase activity
H7R84_RS11495	COG1214	PFAM Peptidase M22, glycoprotease
H7R84_RS11500	COG1199	ATP-dependent helicase activity
H7R84_RS11510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7R84_RS11515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7R84_RS11520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7R84_RS11525	COG0131	Imidazoleglycerol-phosphate dehydratase
H7R84_RS11525	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R84_RS11530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7R84_RS11535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7R84_RS11540	COG3437	response regulator, receiver
H7R84_RS11545	COG2199	diguanylate cyclase activity
H7R84_RS11550	COG2198	Histidine kinase
H7R84_RS11550	COG0784	Response regulator, receiver
H7R84_RS11550	COG2205	protein histidine kinase activity
H7R84_RS11555	COG0107	imidazoleglycerol-phosphate synthase activity
H7R84_RS11570	COG2199	diguanylate cyclase activity
H7R84_RS11575	COG0318	PFAM AMP-dependent synthetase and ligase
H7R84_RS11580	COG1288	antiporter activity
H7R84_RS11590	COG3134	Outer membrane lipoprotein
H7R84_RS11595	COG2080	2 iron, 2 sulfur cluster binding
H7R84_RS11600	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7R84_RS11605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7R84_RS11610	COG2252	PERMEase
H7R84_RS11615	COG0402	S-adenosylhomocysteine deaminase activity
H7R84_RS11620	COG2233	PERMEase
H7R84_RS11625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7R84_RS11625	COG2080	2 iron, 2 sulfur cluster binding
H7R84_RS11630	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7R84_RS11635	COG0402	S-adenosylhomocysteine deaminase activity
H7R84_RS11640	COG0493	'glutamate synthase
H7R84_RS11640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R84_RS11645	COG2068	MobA-Related Protein
H7R84_RS11650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7R84_RS11655	COG3608	succinylglutamate desuccinylase aspartoacylase
H7R84_RS11655	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7R84_RS11665	COG0697	spore germination
H7R84_RS11670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R84_RS11675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R84_RS11690	COG0549	Belongs to the carbamate kinase family
H7R84_RS11700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7R84_RS11705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7R84_RS11710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7R84_RS11725	COG3039	Transposase
H7R84_RS11735	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R84_RS11740	COG0641	radical SAM
H7R84_RS11765	COG0242	peptide deformylase activity
H7R84_RS11785	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7R84_RS11790	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H7R84_RS11800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R84_RS11805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H7R84_RS11815	COG0205	6-phosphofructokinase activity
H7R84_RS11820	COG1301	dicarboxylic acid transport
H7R84_RS11825	COG3039	Transposase
H7R84_RS11830	COG3123	guanosine phosphorylase activity
H7R84_RS11835	COG1760	l-serine dehydratase
H7R84_RS11840	COG1760	l-serine dehydratase
H7R84_RS11845	COG3100	YcgL domain-containing protein
H7R84_RS11850	COG0850	regulation of cytokinetic process
H7R84_RS11855	COG2894	cell division
H7R84_RS11860	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7R84_RS11865	COG3099	Belongs to the UPF0263 family
H7R84_RS11870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R84_RS11910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7R84_RS11915	COG0697	spore germination
H7R84_RS11920	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H7R84_RS11925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R84_RS11940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R84_RS11945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R84_RS11950	COG0307	riboflavin synthase, alpha
H7R84_RS11990	COG3829	transcription factor binding
H7R84_RS12000	COG4681	YaeQ
H7R84_RS12015	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R84_RS12020	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7R84_RS12025	COG0586	Pfam SNARE associated Golgi protein
H7R84_RS12035	COG0556	nucleotide-excision repair
H7R84_RS12045	COG2985	domain, Protein
H7R84_RS12045	COG0569	domain protein
H7R84_RS12070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7R84_RS12075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R84_RS12075	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7R84_RS12090	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R84_RS12105	COG1451	nucleotide metabolic process
H7R84_RS12120	COG0417	DNA replication proofreading
H7R84_RS12130	COG2199	diguanylate cyclase activity
H7R84_RS12130	COG2203	Gaf domain
H7R84_RS12145	COG1560	Kdo2-lipid A biosynthetic process
H7R84_RS12150	COG1560	Kdo2-lipid A biosynthetic process
H7R84_RS12165	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H7R84_RS12180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7R84_RS12185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7R84_RS12190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7R84_RS12195	COG2832	Protein of unknown function (DUF454)
H7R84_RS12200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R84_RS12215	COG1011	Hydrolase
H7R84_RS12220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R84_RS12275	COG3593	DNA synthesis involved in DNA repair
H7R84_RS12290	COG0583	DNA-binding transcription factor activity
H7R84_RS12295	COG0730	response to heat
H7R84_RS12300	COG3148	PFAM DTW domain containing protein
H7R84_RS12305	COG1940	carbohydrate kinase activity
H7R84_RS12305	COG1846	Transcriptional regulator
H7R84_RS12310	COG0840	transmembrane signaling receptor activity
H7R84_RS12315	COG3012	SEC-C Motif Domain Protein
H7R84_RS12320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7R84_RS12325	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
H7R84_RS12330	COG0247	lactate metabolic process
H7R84_RS12355	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H7R84_RS12360	COG0437	4 iron, 4 sulfur cluster binding
H7R84_RS12365	COG3301	Polysulphide reductase, NrfD
H7R84_RS12370	COG1138	Cytochrome C-type biogenesis protein
H7R84_RS12380	COG3088	subunit of a heme lyase
H7R84_RS12380	COG4235	cytochrome complex assembly
H7R84_RS12410	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R84_RS12415	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R84_RS12420	COG0567	Dehydrogenase, E1 component
H7R84_RS12430	COG1053	succinate dehydrogenase
H7R84_RS12435	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7R84_RS12470	COG1742	UPF0060 membrane protein
H7R84_RS12485	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7R84_RS12500	COG2501	S4 domain
H7R84_RS12510	COG1132	(ABC) transporter
H7R84_RS12515	COG1132	(ABC) transporter
H7R84_RS12525	COG3118	belongs to the thioredoxin family
H7R84_RS12530	COG0471	metal ion transport
H7R84_RS12535	COG0058	SHG alpha-glucan phosphorylase activity
H7R84_RS12565	COG2062	phosphohistidine phosphatase, SixA
H7R84_RS12570	COG1025	Belongs to the peptidase M16 family
H7R84_RS12590	COG3039	Transposase
H7R84_RS12600	COG0519	Catalyzes the synthesis of GMP from XMP
H7R84_RS12600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R84_RS12605	COG0516	GMP reductase activity
H7R84_RS12605	COG0517	IMP dehydrogenase activity
H7R84_RS12610	COG1278	Cold shock
H7R84_RS12615	COG1570	exodeoxyribonuclease VII activity
H7R84_RS12620	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7R84_RS12630	COG0386	Belongs to the glutathione peroxidase family
H7R84_RS12635	COG0513	Belongs to the DEAD box helicase family
H7R84_RS12645	COG0840	transmembrane signaling receptor activity
H7R84_RS12650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R84_RS12655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7R84_RS12660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7R84_RS12680	COG0644	oxidoreductase
H7R84_RS12680	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H7R84_RS12720	COG5001	Diguanylate cyclase
H7R84_RS12720	COG3300	MHYT domain
H7R84_RS12735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R84_RS12745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7R84_RS12750	COG0563	adenylate kinase activity
H7R84_RS12760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7R84_RS12765	COG1286	toxin biosynthetic process
H7R84_RS12775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7R84_RS12780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7R84_RS12785	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7R84_RS12790	COG1674	ftsk spoiiie
H7R84_RS12790	COG0531	amino acid
H7R84_RS12800	COG0686	Belongs to the AlaDH PNT family
H7R84_RS12805	COG0492	ferredoxin-NADP+ reductase activity
H7R84_RS12810	COG3706	GGDEF domain
H7R84_RS12815	COG3134	Outer membrane lipoprotein
H7R84_RS12820	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7R84_RS12825	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7R84_RS12830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7R84_RS12835	COG0542	response to heat
H7R84_RS12840	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7R84_RS12845	COG1278	Cold shock
H7R84_RS12850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7R84_RS12870	COG0745	RESPONSE REGULATOR receiver
H7R84_RS12875	COG2205	protein histidine kinase activity
H7R84_RS12885	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7R84_RS12885	COG0392	lysyltransferase activity
H7R84_RS12925	COG4974	Belongs to the 'phage' integrase family
H7R84_RS12950	COG1435	thymidine kinase activity
H7R84_RS12955	COG1757	Na H antiporter
H7R84_RS12960	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R84_RS12965	COG2096	Adenosyltransferase
H7R84_RS12970	COG3530	Putative quorum-sensing-regulated virulence factor
H7R84_RS12975	COG0602	queuosine metabolic process
H7R84_RS12980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7R84_RS13000	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7R84_RS13010	COG0776	regulation of translation
H7R84_RS13015	COG0539	negative regulation of cytoplasmic translation
H7R84_RS13020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7R84_RS13025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R84_RS13040	COG2814	Major facilitator Superfamily
H7R84_RS13060	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H7R84_RS13065	COG3300	MHYT domain
H7R84_RS13065	COG5001	Diguanylate cyclase
H7R84_RS13075	COG0583	DNA-binding transcription factor activity
H7R84_RS13080	COG3437	response regulator, receiver
H7R84_RS13105	COG4989	oxidoreductase activity
H7R84_RS13110	COG0724	RNA recognition motif
H7R84_RS13120	COG1126	abc transporter atp-binding protein
H7R84_RS13125	COG0765	amino acid transport
H7R84_RS13130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R84_RS13135	COG0765	amino acid transport
H7R84_RS13140	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H7R84_RS13150	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H7R84_RS13175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7R84_RS13185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R84_RS13190	COG1360	Flagellar Motor Protein
H7R84_RS13195	COG4771	TonB-dependent receptor
H7R84_RS13200	COG1770	oligopeptidase
H7R84_RS13225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R84_RS13230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R84_RS13235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R84_RS13235	COG0649	NAD binding
H7R84_RS13250	COG1034	ATP synthesis coupled electron transport
H7R84_RS13255	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7R84_RS13260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R84_RS13265	COG0839	Belongs to the complex I subunit 6 family
H7R84_RS13270	COG0713	ATP synthesis coupled electron transport
H7R84_RS13280	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R84_RS13285	COG1007	ATP synthesis coupled electron transport
H7R84_RS13290	COG0047	phosphoribosylformylglycinamidine synthase activity
H7R84_RS13290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7R84_RS13295	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R84_RS13300	COG1645	bacterial-type flagellum-dependent swarming motility
H7R84_RS13305	COG1160	GTP binding
H7R84_RS13310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R84_RS13315	COG2976	Protein conserved in bacteria
H7R84_RS13320	COG0124	histidyl-tRNA synthetase
H7R84_RS13325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7R84_RS13330	COG1426	Protein conserved in bacteria
H7R84_RS13340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7R84_RS13345	COG0105	UTP biosynthetic process
H7R84_RS13360	COG0633	Ferredoxin
H7R84_RS13365	COG0443	Heat shock 70 kDa protein
H7R84_RS13370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R84_RS13380	COG0822	iron-sulfur transferase activity
H7R84_RS13385	COG1104	cysteine desulfurase activity
H7R84_RS13390	COG1959	2 iron, 2 sulfur cluster binding
H7R84_RS13410	COG5642	Protein of unknown function (DUF2384)
H7R84_RS13430	COG3039	Transposase
H7R84_RS13480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R84_RS13480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R84_RS13485	COG0509	glycine decarboxylation via glycine cleavage system
H7R84_RS13490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7R84_RS13500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R84_RS13505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R84_RS13525	COG2814	Major facilitator Superfamily
H7R84_RS13530	COG0625	glutathione transferase activity
H7R84_RS13540	COG0483	inositol monophosphate 1-phosphatase activity
H7R84_RS13555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7R84_RS13570	COG1086	Polysaccharide biosynthesis protein
H7R84_RS13575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7R84_RS13590	COG0574	Belongs to the PEP-utilizing enzyme family
H7R84_RS13590	COG3848	Pyruvate phosphate dikinase
H7R84_RS13610	COG3039	Transposase
H7R84_RS13615	COG0529	Catalyzes the synthesis of activated sulfate
H7R84_RS13640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7R84_RS13650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7R84_RS13670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7R84_RS13690	COG1442	glycosyl transferase family 8
H7R84_RS13695	COG1215	transferase activity, transferring glycosyl groups
H7R84_RS13710	COG0318	PFAM AMP-dependent synthetase and ligase
H7R84_RS13715	COG1028	Short-chain dehydrogenase reductase Sdr
H7R84_RS13730	COG1083	cytidylyl-transferase
H7R84_RS13740	COG2089	acid synthase
H7R84_RS13760	COG4310	Domain of unknown function (DUF2172)
H7R84_RS13815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7R84_RS13830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R84_RS13830	COG0301	tRNA thio-modification
H7R84_RS13845	COG4953	penicillin-binding protein 1C
H7R84_RS13850	COG2373	Large extracellular alpha-helical protein
H7R84_RS13860	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R84_RS13865	COG3300	MHYT domain
H7R84_RS13865	COG5001	Diguanylate cyclase
H7R84_RS13870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R84_RS13880	COG1252	NADH dehydrogenase
H7R84_RS13885	COG3150	esterase
H7R84_RS13890	COG2233	PERMEase
H7R84_RS13900	COG2354	Protein conserved in bacteria
H7R84_RS13915	COG1301	dicarboxylic acid transport
H7R84_RS13930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7R84_RS13945	COG0537	adenosine 5'-monophosphoramidase activity
H7R84_RS13980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R84_RS13985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R84_RS13995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R84_RS14000	COG1605	Chorismate mutase
H7R84_RS14000	COG0287	Prephenate dehydrogenase
H7R84_RS14015	COG1199	ATP-dependent helicase activity
H7R84_RS14025	COG3385	transposase activity
H7R84_RS14030	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7R84_RS14035	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7R84_RS14040	COG1785	Belongs to the alkaline phosphatase family
H7R84_RS14060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R84_RS14065	COG2197	response regulator
H7R84_RS14080	COG3706	GGDEF domain
H7R84_RS14085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R84_RS14090	COG0765	amino acid transport
H7R84_RS14095	COG1126	abc transporter atp-binding protein
H7R84_RS14110	COG0531	amino acid
H7R84_RS14125	COG1253	flavin adenine dinucleotide binding
H7R84_RS14130	COG0704	Plays a role in the regulation of phosphate uptake
H7R84_RS14135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7R84_RS14140	COG0581	inorganic phosphate transmembrane transporter activity
H7R84_RS14145	COG0573	inorganic phosphate transmembrane transporter activity
H7R84_RS14150	COG0590	tRNA wobble adenosine to inosine editing
H7R84_RS14170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7R84_RS14190	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7R84_RS14195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7R84_RS14200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7R84_RS14205	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7R84_RS14230	COG2716	regulation of RNA biosynthetic process
H7R84_RS14235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7R84_RS14245	COG2239	Acts as a magnesium transporter
H7R84_RS14265	COG1706	bacterial-type flagellum-dependent cell motility
H7R84_RS14270	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7R84_RS14280	COG4787	bacterial-type flagellum-dependent cell motility
H7R84_RS14285	COG3385	transposase activity
H7R84_RS14290	COG1749	Flagellar hook protein flgE
H7R84_RS14295	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7R84_RS14305	COG1815	bacterial-type flagellum-dependent cell motility
H7R84_RS14310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7R84_RS14315	COG0835	chemotaxis
H7R84_RS14315	COG0784	Response regulator, receiver
H7R84_RS14320	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H7R84_RS14335	COG0622	Phosphoesterase
H7R84_RS14340	COG4166	transmembrane transport
H7R84_RS14350	COG1187	pseudouridine synthase activity
H7R84_RS14365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R84_RS14370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R84_RS14375	COG1882	Formate acetyltransferase
H7R84_RS14380	COG1349	DNA-binding transcription factor activity
H7R84_RS14385	COG0697	spore germination
H7R84_RS14400	COG0583	DNA-binding transcription factor activity
H7R84_RS14415	COG1121	(ABC) transporter
H7R84_RS14450	COG4771	TonB-dependent receptor
H7R84_RS14465	COG1278	Cold shock
H7R84_RS14490	COG4771	TonB-dependent receptor
H7R84_RS14500	COG0741	lytic transglycosylase activity
H7R84_RS14510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7R84_RS14530	COG2911	Protein conserved in bacteria
H7R84_RS14535	COG0729	surface antigen
H7R84_RS14545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R84_RS14550	COG3039	Transposase
H7R84_RS14580	COG2003	Belongs to the UPF0758 family
H7R84_RS14655	COG1660	Displays ATPase and GTPase activities
H7R84_RS14680	COG3173	Aminoglycoside phosphotransferase
H7R84_RS14740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7R84_RS14750	COG4134	Bacterial extracellular solute-binding protein
H7R84_RS14760	COG4136	ATPase activity
H7R84_RS14765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7R84_RS14770	COG2951	lytic endotransglycosylase activity
H7R84_RS14775	COG0033	Phosphoglucomutase
H7R84_RS14780	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H7R84_RS14785	COG0596	Alpha beta hydrolase
H7R84_RS14800	COG0716	FMN binding
H7R84_RS14810	COG0735	belongs to the Fur family
H7R84_RS14815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R84_RS14825	COG2190	(PTS) system
H7R84_RS14825	COG1263	PTS System
H7R84_RS14825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R84_RS14830	COG0363	glucosamine-6-phosphate deaminase activity
H7R84_RS14835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R84_RS14840	COG1940	carbohydrate kinase activity
H7R84_RS14840	COG1846	Transcriptional regulator
H7R84_RS14845	COG2194	sulfuric ester hydrolase activity
H7R84_RS14860	COG3275	phosphorelay sensor kinase activity
H7R84_RS14865	COG3279	Response regulator of the LytR AlgR family
H7R84_RS14870	COG1966	Carbon starvation protein
H7R84_RS14880	COG1566	PFAM secretion protein HlyD family protein
H7R84_RS14885	COG1061	Type III restriction enzyme res subunit
H7R84_RS14890	COG2027	D-alanyl-D-alanine carboxypeptidase
H7R84_RS14895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7R84_RS14900	COG3021	interspecies interaction between organisms
H7R84_RS14910	COG1607	acyl-coa hydrolase
H7R84_RS14915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R84_RS14925	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7R84_RS14925	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7R84_RS14925	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7R84_RS14925	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7R84_RS14940	COG3217	Mosc domain protein beta barrel domain protein
H7R84_RS14940	COG3217	Mosc domain protein beta barrel domain protein
H7R84_RS14940	COG0633	Ferredoxin
H7R84_RS14940	COG0633	Ferredoxin
H7R84_RS14950	COG0501	Belongs to the peptidase M48B family
H7R84_RS14955	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7R84_RS14960	COG1073	alpha beta
H7R84_RS14960	COG2226	methyltransferase
H7R84_RS14965	COG0156	8-amino-7-oxononanoate synthase activity
H7R84_RS14970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R84_RS14975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7R84_RS14990	COG0017	Asparaginyl-tRNA synthetase
H7R84_RS15000	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R84_RS15010	COG1473	amidohydrolase
H7R84_RS15015	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R84_RS15025	COG1393	Belongs to the ArsC family
H7R84_RS15030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7R84_RS15035	COG1876	peptidase activity
H7R84_RS15095	COG3039	Transposase
H7R84_RS15100	COG2932	Transcriptional regulator
H7R84_RS15105	COG3263	regulation of cellular component size
H7R84_RS15120	COG1280	lysine exporter protein (LysE YggA)
H7R84_RS15145	COG1957	nucleoside hydrolase
H7R84_RS15230	COG4397	Mu-like prophage major head subunit gpT
H7R84_RS15235	COG4388	Caudovirus prohead serine protease
H7R84_RS15255	COG4383	Mu-like prophage protein gp29
H7R84_RS15260	COG4373	Mu-like prophage FluMu protein gp28
H7R84_RS15270	COG0640	Transcriptional regulator
H7R84_RS15395	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R84_RS15400	COG0702	epimerase
H7R84_RS15410	COG0095	Lipoate-protein ligase
H7R84_RS15420	COG1136	(ABC) transporter
H7R84_RS15420	COG0577	efflux transmembrane transporter activity
H7R84_RS15425	COG1136	(ABC) transporter
H7R84_RS15425	COG0577	efflux transmembrane transporter activity
H7R84_RS15430	COG1136	(ABC) transporter
H7R84_RS15430	COG0577	efflux transmembrane transporter activity
H7R84_RS15435	COG1566	PFAM secretion protein HlyD family protein
H7R84_RS15470	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R84_RS15480	COG1285	pathogenesis
H7R84_RS15510	COG0484	heat shock protein binding
H7R84_RS15515	COG0443	Heat shock 70 kDa protein
H7R84_RS15520	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7R84_RS15525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7R84_RS15530	COG0497	DNA recombination
H7R84_RS15535	COG1227	inorganic diphosphatase activity
H7R84_RS15540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R84_RS15545	COG1136	(ABC) transporter
H7R84_RS15545	COG0577	efflux transmembrane transporter activity
H7R84_RS15565	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H7R84_RS15580	COG3385	transposase activity
H7R84_RS15585	COG1091	dTDP-4-dehydrorhamnose reductase activity
H7R84_RS15600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7R84_RS15615	COG0297	glycogen (starch) synthase activity
H7R84_RS15620	COG3306	glycosyltransferase involved in LPS biosynthesis
H7R84_RS15655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7R84_RS15665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R84_RS15670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R84_RS15675	COG1309	transcriptional regulator
H7R84_RS15690	COG1342	Belongs to the UPF0251 family
H7R84_RS15720	COG0625	glutathione transferase activity
H7R84_RS15725	COG0259	pyridoxamine-phosphate oxidase activity
H7R84_RS15770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R84_RS15770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R84_RS15775	COG0251	oxidation-reduction process
H7R84_RS15780	COG1882	Formate acetyltransferase
H7R84_RS15785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R84_RS15795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7R84_RS15800	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7R84_RS15820	COG3088	subunit of a heme lyase
H7R84_RS15820	COG4235	cytochrome complex assembly
H7R84_RS15825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R84_RS15830	COG1138	Cytochrome C-type biogenesis protein
H7R84_RS15835	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7R84_RS15840	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R84_RS15845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R84_RS15850	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R84_RS15865	COG0835	chemotaxis
H7R84_RS15875	COG1192	Involved in chromosome partitioning
H7R84_RS15880	COG1360	Flagellar Motor Protein
H7R84_RS15885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R84_RS15890	COG2201	protein-glutamate methylesterase activity
H7R84_RS15895	COG2198	Histidine kinase
H7R84_RS15895	COG0784	Response regulator, receiver
H7R84_RS15895	COG0643	Histidine kinase
H7R84_RS15900	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H7R84_RS15925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7R84_RS15935	COG1684	flagellar biosynthetic protein fliR
H7R84_RS15990	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7R84_RS16000	COG1677	Flagellar hook-basal body complex protein FliE
H7R84_RS16015	COG0469	pyruvate kinase activity
H7R84_RS16020	COG1737	Transcriptional regulator
H7R84_RS16025	COG0837	glucose binding
H7R84_RS16055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R84_RS16065	COG0281	malic enzyme
H7R84_RS16085	COG0437	4 iron, 4 sulfur cluster binding
H7R84_RS16090	COG3383	formate dehydrogenase (NAD+) activity
H7R84_RS16090	COG3383	formate dehydrogenase (NAD+) activity
H7R84_RS16120	COG3039	Transposase
H7R84_RS16135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7R84_RS16145	COG3852	Histidine kinase
H7R84_RS16150	COG2204	response regulator
H7R84_RS16160	COG4662	Binding-protein-dependent transport system inner membrane component
H7R84_RS16170	COG0746	molybdenum cofactor guanylyltransferase activity
H7R84_RS16175	COG0303	'Molybdopterin
H7R84_RS16180	COG1289	transmembrane transporter activity
H7R84_RS16220	COG0784	Response regulator, receiver
H7R84_RS16220	COG2205	protein histidine kinase activity
H7R84_RS16235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R84_RS16240	COG0444	Belongs to the ABC transporter superfamily
H7R84_RS16245	COG4608	Belongs to the ABC transporter superfamily
H7R84_RS16255	COG2971	BadF BadG BcrA BcrD
H7R84_RS16280	COG3724	N-succinylarginine dihydrolase activity
H7R84_RS16310	COG0826	peptidase U32
H7R84_RS16315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R84_RS16330	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R84_RS16335	COG3706	GGDEF domain
H7R84_RS16340	COG2211	Major facilitator Superfamily
H7R84_RS16345	COG0616	signal peptide processing
H7R84_RS16350	COG1028	Short-chain dehydrogenase reductase Sdr
H7R84_RS16355	COG0583	DNA-binding transcription factor activity
H7R84_RS16365	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7R84_RS16380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7R84_RS16385	COG1881	PFAM PEBP family protein
H7R84_RS16400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7R84_RS16420	COG1301	dicarboxylic acid transport
H7R84_RS16425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7R84_RS16430	COG2912	Transglutaminase-like superfamily
H7R84_RS16440	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R84_RS16445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7R84_RS16450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7R84_RS16455	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H7R84_RS16460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7R84_RS16470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7R84_RS16475	COG0737	Belongs to the 5'-nucleotidase family
H7R84_RS16480	COG0193	aminoacyl-tRNA hydrolase activity
H7R84_RS16485	COG0012	GTP binding
H7R84_RS16530	COG0471	metal ion transport
H7R84_RS16530	COG0490	domain, Protein
H7R84_RS16540	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H7R84_RS16560	COG0366	Alpha amylase catalytic
H7R84_RS16565	COG0488	(ABC) transporter
H7R84_RS16575	COG3385	transposase activity
H7R84_RS16585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R84_RS16600	COG1012	belongs to the aldehyde dehydrogenase family
H7R84_RS16610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7R84_RS16615	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R84_RS16625	COG0180	Tryptophanyl-tRNA synthetase
H7R84_RS16635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7R84_RS16640	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H7R84_RS16650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7R84_RS16655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7R84_RS16685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7R84_RS16695	COG0583	DNA-binding transcription factor activity
H7R84_RS16715	COG0583	DNA-binding transcription factor activity
H7R84_RS16725	COG0739	heme binding
H7R84_RS16735	COG1511	domain protein
H7R84_RS16735	COG3264	Mechanosensitive ion channel
H7R84_RS16740	COG0584	glycerophosphoryl diester phosphodiesterase
H7R84_RS16750	COG1053	succinate dehydrogenase
H7R84_RS16755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7R84_RS16760	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R84_RS16765	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R84_RS16775	COG0602	queuosine metabolic process
H7R84_RS16790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7R84_RS16795	COG3115	cell septum assembly
H7R84_RS16800	COG1196	nuclear chromosome segregation
H7R84_RS16810	COG2860	membrane
H7R84_RS16820	COG3108	Peptidase M15
H7R84_RS16825	COG2989	Protein conserved in bacteria
H7R84_RS16840	COG0463	Glycosyl transferase, family 2
H7R84_RS16855	COG0366	Alpha amylase catalytic
H7R84_RS16890	COG2203	Gaf domain
H7R84_RS16890	COG2199	diguanylate cyclase activity
H7R84_RS16900	COG3590	peptidase
H7R84_RS16915	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7R84_RS16920	COG1982	Orn Lys Arg decarboxylase major
H7R84_RS16925	COG0531	amino acid
H7R84_RS16935	COG3710	Transcriptional regulator
H7R84_RS16940	COG0531	amino acid
H7R84_RS16945	COG0814	amino acid
H7R84_RS16960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R84_RS16965	COG0739	heme binding
H7R84_RS16970	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7R84_RS16975	COG0251	oxidation-reduction process
H7R84_RS16985	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7R84_RS16995	COG3091	SprT-like family
H7R84_RS17005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7R84_RS17010	COG0189	ligase activity
H7R84_RS17035	COG1022	Amp-dependent synthetase and ligase
H7R84_RS17045	COG4221	oxidoreductase activity
H7R84_RS17060	COG0642	Histidine kinase
H7R84_RS17070	COG0516	GMP reductase activity
H7R84_RS17080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7R84_RS17085	COG3647	Membrane
H7R84_RS17095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R84_RS17130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R84_RS17135	COG0473	3-isopropylmalate dehydrogenase activity
H7R84_RS17145	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H7R84_RS17150	COG2363	Small membrane protein
H7R84_RS17160	COG0583	DNA-binding transcription factor activity
H7R84_RS17165	COG0840	transmembrane signaling receptor activity
H7R84_RS17170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7R84_RS17185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7R84_RS17190	COG1666	GTP binding
H7R84_RS17200	COG2211	Major facilitator Superfamily
H7R84_RS17205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R84_RS17215	COG2813	Specifically methylates the guanine in position
H7R84_RS17220	COG0271	Belongs to the BolA IbaG family
H7R84_RS17225	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R84_RS17230	COG1805	sodium ion transport
H7R84_RS17235	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R84_RS17240	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R84_RS17245	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R84_RS17250	COG2871	sodium ion transport
H7R84_RS17255	COG1477	protein flavinylation
H7R84_RS17285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7R84_RS17300	COG0300	oxidoreductase activity
H7R84_RS17310	COG0415	Belongs to the DNA photolyase family
H7R84_RS17315	COG0789	Transcriptional regulator
H7R84_RS17320	COG3272	Protein of unknown function (DUF1722)
H7R84_RS17350	COG1605	Chorismate mutase
H7R84_RS17350	COG0077	Prephenate dehydratase
H7R84_RS17410	COG1160	GTP binding
H7R84_RS17465	COG0300	oxidoreductase activity
H7R84_RS17490	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H7R84_RS17530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7R84_RS17535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R84_RS17545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R84_RS17550	COG0826	peptidase U32
H7R84_RS17555	COG1280	lysine exporter protein (LysE YggA)
H7R84_RS17565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R84_RS17585	COG2198	Histidine kinase
H7R84_RS17585	COG0643	Histidine kinase
H7R84_RS17595	COG0835	chemotaxis
H7R84_RS17600	COG0840	transmembrane signaling receptor activity
H7R84_RS17610	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H7R84_RS17615	COG2201	protein-glutamate methylesterase activity
H7R84_RS17620	COG1185	polyribonucleotide nucleotidyltransferase activity
H7R84_RS17625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7R84_RS17630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7R84_RS17635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7R84_RS17640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7R84_RS17645	COG0195	Participates in both transcription termination and antitermination
H7R84_RS17650	COG0779	Required for maturation of 30S ribosomal subunits
H7R84_RS17665	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7R84_RS17670	COG0149	triose-phosphate isomerase activity
H7R84_RS17675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7R84_RS17680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7R84_RS17690	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7R84_RS17695	COG1534	Rna-binding protein
H7R84_RS17710	COG1360	Flagellar Motor Protein
H7R84_RS17715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R84_RS17720	COG1722	exodeoxyribonuclease VII activity
H7R84_RS17725	COG0142	geranyltranstransferase activity
H7R84_RS17730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7R84_RS17745	COG2814	Major facilitator Superfamily
H7R84_RS17770	COG0748	coenzyme F420 binding
H7R84_RS17775	COG3721	Heme iron utilization protein
H7R84_RS17785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R84_RS17800	COG3275	phosphorelay sensor kinase activity
H7R84_RS17805	COG3279	Response regulator of the LytR AlgR family
H7R84_RS17810	COG1966	Carbon starvation protein
H7R84_RS17820	COG3340	Belongs to the peptidase S51 family
H7R84_RS17830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R84_RS17845	COG1047	Peptidyl-prolyl cis-trans
H7R84_RS17850	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H7R84_RS17860	COG0835	chemotaxis
H7R84_RS17860	COG0784	Response regulator, receiver
H7R84_RS17865	COG0429	hydrolase of the alpha beta-hydrolase fold
H7R84_RS17875	COG3089	Belongs to the UPF0270 family
H7R84_RS17880	COG3954	Phosphoribulokinase
H7R84_RS17895	COG1765	OsmC-like protein
H7R84_RS17935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R84_RS17940	COG2313	pseudouridylate synthase activity
H7R84_RS17945	COG3385	transposase activity
H7R84_RS17970	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
H7R84_RS17975	COG5001	Diguanylate cyclase
H7R84_RS17975	COG3300	MHYT domain
H7R84_RS18000	COG2985	domain, Protein
H7R84_RS18000	COG0569	domain protein
H7R84_RS18005	COG1272	protein, Hemolysin III
H7R84_RS18010	COG0076	glutamate decarboxylase activity
H7R84_RS18015	COG2917	probably involved in intracellular septation
H7R84_RS18020	COG2350	Protein conserved in bacteria
H7R84_RS18030	COG1349	DNA-binding transcription factor activity
H7R84_RS18040	COG2222	sugar isomerase
H7R84_RS18045	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R84_RS18055	COG3716	PTS system mannose fructose sorbose family IID component
H7R84_RS18060	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R84_RS18065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R84_RS18075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7R84_RS18080	COG1381	Involved in DNA repair and RecF pathway recombination
H7R84_RS18090	COG0571	ribonuclease III activity
H7R84_RS18095	COG0681	Belongs to the peptidase S26 family
H7R84_RS18100	COG0481	GTPase activity
H7R84_RS18110	COG3026	antisigma factor binding
H7R84_RS18115	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H7R84_RS18120	COG1595	DNA-templated transcription, initiation
H7R84_RS18125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7R84_RS18135	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H7R84_RS18140	COG0354	folic acid binding
H7R84_RS18165	COG4232	protein-disulfide reductase activity
H7R84_RS18180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R84_RS18185	COG0191	fructose-bisphosphate aldolase activity
H7R84_RS18190	COG0126	phosphoglycerate kinase activity
H7R84_RS18195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R84_RS18200	COG1940	carbohydrate kinase activity
H7R84_RS18205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7R84_RS18210	COG2816	NAD+ diphosphatase activity
H7R84_RS18220	COG4991	sh3 domain protein
H7R84_RS18225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R84_RS18255	COG0741	lytic transglycosylase activity
H7R84_RS18260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7R84_RS18275	COG0488	(ABC) transporter
H7R84_RS18285	COG2252	PERMEase
H7R84_RS18290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R84_RS18295	COG0840	transmembrane signaling receptor activity
H7R84_RS18305	COG1278	Cold shock
H7R84_RS18345	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7R84_RS18355	COG0688	phosphatidylethanolamine metabolic process
H7R84_RS18360	COG4628	conserved protein (DUF2132)
H7R84_RS18375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7R84_RS18390	COG1073	alpha beta
H7R84_RS18395	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H7R84_RS18400	COG4974	Belongs to the 'phage' integrase family
H7R84_RS18435	COG3274	enterobacterial common antigen metabolic process
H7R84_RS18440	COG4695	Portal protein
H7R84_RS18460	COG0529	Catalyzes the synthesis of activated sulfate
H7R84_RS18465	COG3273	potassium ion transport
H7R84_RS18465	COG0471	metal ion transport
H7R84_RS18470	COG2895	sulfate adenylyltransferase (ATP) activity
H7R84_RS18475	COG0175	sulfate reduction
H7R84_RS18480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R84_RS18480	COG1648	precorrin-2 dehydrogenase activity
H7R84_RS18485	COG0330	HflC and HflK could
H7R84_RS18490	COG1585	Membrane protein implicated in regulation of membrane protease activity
H7R84_RS18495	COG0840	transmembrane signaling receptor activity
H7R84_RS18500	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7R84_RS18505	COG0676	glucose-6-phosphate 1-epimerase activity
H7R84_RS18510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R84_RS18515	COG1640	4-alpha-glucanotransferase
H7R84_RS18520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7R84_RS18570	COG0561	phosphatase activity
H7R84_RS18585	COG0733	neurotransmitter:sodium symporter activity
H7R84_RS18595	COG0733	neurotransmitter:sodium symporter activity
H7R84_RS18660	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H7R84_RS18665	COG2885	chlorophyll binding
H7R84_RS18670	COG0823	Involved in the tonB-independent uptake of proteins
H7R84_RS18685	COG0811	peptide transport
H7R84_RS18690	COG0824	Thioesterase
H7R84_RS18695	COG3790	cyd operon protein YbgE
H7R84_RS18700	COG4890	Cyd operon protein YbgT
H7R84_RS18705	COG1294	oxidase, subunit
H7R84_RS18715	COG2255	four-way junction helicase activity
H7R84_RS18720	COG0632	four-way junction helicase activity
H7R84_RS18740	COG2771	luxR family
H7R84_RS18755	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H7R84_RS18760	COG2203	Gaf domain
H7R84_RS18760	COG3706	GGDEF domain
H7R84_RS18760	COG4251	negative regulation of phosphorylation
H7R84_RS18760	COG5001	Diguanylate cyclase
H7R84_RS18770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R84_RS18780	COG2995	paraquat-inducible protein a
H7R84_RS18785	COG3008	intermembrane lipid transfer
H7R84_RS18785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R84_RS18795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R84_RS18800	COG0442	prolyl-tRNA aminoacylation
H7R84_RS18805	COG4221	oxidoreductase activity
H7R84_RS18820	COG1024	Enoyl-CoA hydratase
H7R84_RS18830	COG0110	maltose O-acetyltransferase activity
H7R84_RS18840	COG4166	transmembrane transport
H7R84_RS18850	COG0840	transmembrane signaling receptor activity
H7R84_RS18855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R84_RS18860	COG0735	belongs to the Fur family
H7R84_RS18885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7R84_RS18890	COG0513	Belongs to the DEAD box helicase family
H7R84_RS18895	COG2153	protein acetylation
H7R84_RS18905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R84_RS18910	COG0557	exoribonuclease II activity
H7R84_RS18915	COG3706	GGDEF domain
H7R84_RS18920	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7R84_RS18920	COG2885	chlorophyll binding
H7R84_RS18925	COG3240	lipase activity
H7R84_RS18930	COG3111	PFAM Bacterial OB fold (BOF) protein
H7R84_RS18940	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H7R84_RS18945	COG1194	a g-specific adenine glycosylase
H7R84_RS18950	COG0617	tRNA 3'-terminal CCA addition
H7R84_RS18970	COG3068	Protein conserved in bacteria
H7R84_RS18980	COG0739	heme binding
H7R84_RS19000	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H7R84_RS19005	COG1121	(ABC) transporter
H7R84_RS19010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7R84_RS19015	COG0583	DNA-binding transcription factor activity
H7R84_RS19025	COG1573	uracil-dna glycosylase
H7R84_RS19040	COG2827	Endonuclease containing a URI domain
H7R84_RS19055	COG1842	Phage shock protein A
H7R84_RS19060	COG0204	Acyl-transferase
H7R84_RS19080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R84_RS19085	COG0484	heat shock protein binding
H7R84_RS19105	COG3104	oligopeptide transport
H7R84_RS19140	COG3150	esterase
H7R84_RS19150	COG3151	Protein conserved in bacteria
H7R84_RS19155	COG0494	nUDIX hydrolase
H7R84_RS19160	COG1538	Outer membrane efflux protein
H7R84_RS19165	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7R84_RS19165	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7R84_RS19170	COG1560	Kdo2-lipid A biosynthetic process
H7R84_RS19175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R84_RS19175	COG2213	PTS system mannitol-specific
H7R84_RS19180	COG0246	Mannitol dehydrogenase
H7R84_RS19185	COG3722	fumarate hydratase activity
H7R84_RS19215	COG1671	Belongs to the UPF0178 family
H7R84_RS19220	COG1988	membrane-bound metal-dependent
H7R84_RS19225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R84_RS19230	COG0513	Belongs to the DEAD box helicase family
H7R84_RS19250	COG1575	Belongs to the MenA family. Type 1 subfamily
H7R84_RS19255	COG1169	isochorismate synthase
H7R84_RS19260	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H7R84_RS19265	COG0596	Alpha beta hydrolase
H7R84_RS19275	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7R84_RS19280	COG1441	menaquinone biosynthetic process
H7R84_RS19285	COG0318	PFAM AMP-dependent synthetase and ligase
H7R84_RS19290	COG3291	Pkd domain containing protein
H7R84_RS19295	COG2949	membrane
H7R84_RS19300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7R84_RS19310	COG0784	Response regulator, receiver
H7R84_RS19310	COG0835	chemotaxis
H7R84_RS19320	COG1444	tRNA N-acetyltransferase activity
H7R84_RS19345	COG1803	Methylglyoxal synthase
H7R84_RS19350	COG1979	alcohol dehydrogenase
H7R84_RS19370	COG4221	oxidoreductase activity
H7R84_RS19405	COG1368	sulfuric ester hydrolase activity
H7R84_RS19410	COG1522	sequence-specific DNA binding
H7R84_RS19420	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H7R84_RS19430	COG1058	Belongs to the CinA family
H7R84_RS19430	COG1546	Belongs to the CinA family
H7R84_RS19440	COG0561	phosphatase activity
H7R84_RS19450	COG2926	Belongs to the UPF0265 family
H7R84_RS19480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R84_RS19485	COG0564	pseudouridine synthase activity
H7R84_RS19495	COG0110	maltose O-acetyltransferase activity
H7R84_RS19500	COG0366	Alpha amylase catalytic
H7R84_RS19505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R84_RS19505	COG1263	PTS System
H7R84_RS19525	COG0252	asparaginase activity
H7R84_RS19530	COG1253	flavin adenine dinucleotide binding
H7R84_RS19535	COG0586	Pfam SNARE associated Golgi protein
H7R84_RS19540	COG1686	Belongs to the peptidase S11 family
H7R84_RS19575	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7R84_RS19585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7R84_RS19595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7R84_RS19600	COG1546	Belongs to the CinA family
H7R84_RS19605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7R84_RS19610	COG4667	esterase of the alpha-beta hydrolase superfamily
H7R84_RS19625	COG1346	cytolysis
H7R84_RS19630	COG1380	Effector of murein hydrolase LrgA
H7R84_RS19635	COG0583	DNA-binding transcription factor activity
H7R84_RS19655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7R84_RS19660	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7R84_RS19670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7R84_RS19675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R84_RS19685	COG0137	argininosuccinate synthase activity
H7R84_RS19690	COG0165	Argininosuccinate lyase
H7R84_RS19710	COG3314	Sporulation integral membrane protein YlbJ
H7R84_RS19735	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7R84_RS19740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7R84_RS19755	COG0477	Major facilitator Superfamily
H7R84_RS19760	COG0523	cobalamin synthesis protein
H7R84_RS19770	COG1280	lysine exporter protein (LysE YggA)
H7R84_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
H7R84_RS19790	COG2200	EAL domain
H7R84_RS19795	COG1049	propionate catabolic process, 2-methylcitrate cycle
H7R84_RS19800	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R84_RS19805	COG0840	transmembrane signaling receptor activity
H7R84_RS19815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R84_RS19820	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R84_RS19825	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7R84_RS19830	COG2186	Transcriptional regulator
H7R84_RS19855	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R84_RS19860	COG1459	type II secretion system
H7R84_RS19875	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H7R84_RS19880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H7R84_RS19885	COG0494	nUDIX hydrolase
H7R84_RS19890	COG0653	protein targeting
H7R84_RS19900	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7R84_RS19905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7R84_RS19910	COG0849	cell division
H7R84_RS19920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R84_RS19925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7R84_RS19930	COG0772	Belongs to the SEDS family
H7R84_RS19935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7R84_RS19940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7R84_RS19945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7R84_RS19955	COG0768	penicillin binding
H7R84_RS19960	COG3116	cell division
H7R84_RS19965	COG0275	rRNA processing
H7R84_RS19970	COG2001	Belongs to the MraZ family
H7R84_RS19980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7R84_RS19985	COG3107	peptidoglycan biosynthetic process
H7R84_RS19990	COG0792	nuclease activity
H7R84_RS19995	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R84_RS20005	COG2969	positive regulation of protein catabolic process
H7R84_RS20010	COG0625	glutathione transferase activity
H7R84_RS20015	COG2857	Cytochrome c1
H7R84_RS20020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7R84_RS20025	COG0723	plastoquinol--plastocyanin reductase activity
H7R84_RS20030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7R84_RS20035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7R84_RS20040	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7R84_RS20050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R84_RS20055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R84_RS20060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R84_RS20065	COG1660	Displays ATPase and GTPase activities
H7R84_RS20070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R84_RS20080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7R84_RS20085	COG1137	ATPase activity
H7R84_RS20090	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7R84_RS20095	COG3117	lipopolysaccharide transmembrane transporter activity
H7R84_RS20100	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7R84_RS20105	COG0517	IMP dehydrogenase activity
H7R84_RS20105	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7R84_RS20110	COG1127	ABC transporter
H7R84_RS20115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7R84_RS20120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R84_RS20125	COG2854	intermembrane phospholipid transfer
H7R84_RS20135	COG5007	Belongs to the BolA IbaG family
H7R84_RS20140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7R84_RS20145	COG0312	modulator of DNA gyrase
H7R84_RS20150	COG3028	Belongs to the UPF0307 family
H7R84_RS20155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7R84_RS20175	COG1011	Hydrolase
H7R84_RS20190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7R84_RS20195	COG0019	diaminopimelate decarboxylase activity
H7R84_RS20205	COG1965	Belongs to the frataxin family
H7R84_RS20210	COG0400	carboxylic ester hydrolase activity
H7R84_RS20215	COG3072	Adenylate cyclase
H7R84_RS20220	COG0181	hydroxymethylbilane synthase activity
H7R84_RS20230	COG2959	enzyme of heme biosynthesis
H7R84_RS20245	COG1494	fructose-1,6-bisphosphatase
H7R84_RS20305	COG1160	GTP binding
H7R84_RS20315	COG0582	viral genome integration into host DNA
H7R84_RS20360	COG0582	viral genome integration into host DNA
H7R84_RS20375	COG0795	lipopolysaccharide-transporting ATPase activity
H7R84_RS20380	COG0795	lipopolysaccharide-transporting ATPase activity
H7R84_RS20385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R84_RS20390	COG2927	DNA polymerase III (CHI subunit)
H7R84_RS20415	COG0454	-acetyltransferase
H7R84_RS20415	COG0456	acetyltransferase
H7R84_RS20420	COG0753	catalase activity
H7R84_RS20425	COG3385	transposase activity
H7R84_RS20450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R84_RS20455	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7R84_RS20460	COG5380	lipid catabolic process
H7R84_RS20475	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H7R84_RS20480	COG4533	DNA binding
H7R84_RS20490	COG2873	o-acetylhomoserine
H7R84_RS20520	COG3842	ATPase activity
H7R84_RS20530	COG1175	transmembrane transport
H7R84_RS20555	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R84_RS20580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R84_RS20585	COG1074	ATP-dependent DNA helicase activity
H7R84_RS20590	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7R84_RS20595	COG2259	Doxx family
H7R84_RS20600	COG1741	Belongs to the pirin family
H7R84_RS20610	COG0583	DNA-binding transcription factor activity
H7R84_RS20640	COG3706	GGDEF domain
H7R84_RS20645	COG4771	TonB-dependent receptor
H7R84_RS20675	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R84_RS20680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R84_RS20685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7R84_RS20690	COG0049	tRNA binding
H7R84_RS20695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7R84_RS20700	COG2168	tRNA wobble position uridine thiolation
H7R84_RS20705	COG2923	Belongs to the DsrF TusC family
H7R84_RS20710	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R84_RS20720	COG2964	Protein conserved in bacteria
H7R84_RS20725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7R84_RS20730	COG0085	RNA polymerase activity
H7R84_RS20735	COG0222	ribosome binding
H7R84_RS20740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7R84_RS20745	COG0081	regulation of translation
H7R84_RS20750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7R84_RS20755	COG0250	Participates in transcription elongation, termination and antitermination
H7R84_RS20770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R84_RS20795	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7R84_RS20800	COG0569	domain protein
H7R84_RS20805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R84_RS20820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R84_RS20820	COG4191	Histidine kinase
H7R84_RS20825	COG3005	denitrification pathway
H7R84_RS20830	COG0243	molybdopterin cofactor binding
H7R84_RS20875	COG2204	response regulator
H7R84_RS20885	COG2205	protein histidine kinase activity
H7R84_RS20900	COG1028	Short-chain dehydrogenase reductase Sdr
H7R84_RS20910	COG5413	integral membrane protein
H7R84_RS20920	COG1522	sequence-specific DNA binding
H7R84_RS20925	COG2502	aspartate--ammonia ligase
H7R84_RS20930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7R84_RS20935	COG0542	response to heat
H7R84_RS20945	COG0564	pseudouridine synthase activity
H7R84_RS20950	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R84_RS20960	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R84_RS20970	COG3681	Belongs to the UPF0597 family
H7R84_RS20975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R84_RS20980	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H7R84_RS20985	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H7R84_RS20990	COG1979	alcohol dehydrogenase
H7R84_RS20995	COG2207	Transcriptional regulator
H7R84_RS21015	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H7R84_RS21045	COG0540	Belongs to the ATCase OTCase family
H7R84_RS21050	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H7R84_RS21055	COG1438	arginine binding
H7R84_RS21060	COG1288	antiporter activity
H7R84_RS21065	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7R84_RS21105	COG3078	GTPase activator activity
H7R84_RS21115	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7R84_RS21130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7R84_RS21135	COG0408	coproporphyrinogen oxidase activity
H7R84_RS21140	COG0009	L-threonylcarbamoyladenylate synthase
H7R84_RS21150	COG0551	DNA topoisomerase type I activity
H7R84_RS21155	COG2922	Belongs to the Smg family
H7R84_RS21160	COG0758	DNA mediated transformation
H7R84_RS21165	COG1652	LysM domain
H7R84_RS21170	COG0242	peptide deformylase activity
H7R84_RS21175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7R84_RS21180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R84_RS21180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R84_RS21185	COG0569	domain protein
H7R84_RS21190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R84_RS21195	COG1217	gtp-binding protein TYPA
H7R84_RS21200	COG0174	glutamine synthetase
H7R84_RS21215	COG2204	response regulator
H7R84_RS21220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7R84_RS21225	COG1322	Protein conserved in bacteria
H7R84_RS21245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R84_RS21250	COG0583	DNA-binding transcription factor activity
H7R84_RS21255	COG0519	Catalyzes the synthesis of GMP from XMP
H7R84_RS21255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R84_RS21265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7R84_RS21270	COG1396	sequence-specific DNA binding
H7R84_RS21275	COG1012	belongs to the aldehyde dehydrogenase family
H7R84_RS21285	COG2962	Rard protein
H7R84_RS21290	COG0840	transmembrane signaling receptor activity
H7R84_RS21295	COG2391	methyltransferase activity
H7R84_RS21310	COG0129	dihydroxy-acid dehydratase activity
H7R84_RS21320	COG3978	acetolactate synthase activity
H7R84_RS21330	COG0606	chelatase, subunit chli
H7R84_RS21350	COG2129	metallophosphoesterase
H7R84_RS21415	COG0606	chelatase, subunit chli
H7R84_RS21420	COG0204	Acyl-transferase
H7R84_RS21425	COG0204	Acyl-transferase
H7R84_RS21430	COG1683	Conserved Protein
H7R84_RS21440	COG1335	isochorismatase
H7R84_RS21450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R84_RS21455	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7R84_RS21465	COG3084	Protein conserved in bacteria
H7R84_RS21470	COG3706	GGDEF domain
H7R84_RS21470	COG4251	negative regulation of phosphorylation
H7R84_RS21470	COG5001	Diguanylate cyclase
H7R84_RS21470	COG2203	Gaf domain
H7R84_RS21485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7R84_RS21495	COG1561	YicC-like family, N-terminal region
H7R84_RS21500	COG1309	transcriptional regulator
H7R84_RS21505	COG1538	Outer membrane efflux protein
H7R84_RS21515	COG2814	Major facilitator Superfamily
H7R84_RS21520	COG0583	DNA-binding transcription factor activity
H7R84_RS21540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7R84_RS21545	COG0385	Bile acid
H7R84_RS21605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7R84_RS21610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R84_RS21610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R84_RS21615	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H7R84_RS21620	COG3074	FtsZ-dependent cytokinesis
H7R84_RS21630	COG1045	serine acetyltransferase
H7R84_RS21640	COG0745	RESPONSE REGULATOR receiver
H7R84_RS21645	COG2205	protein histidine kinase activity
H7R84_RS21650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7R84_RS21655	COG0534	Mate efflux family protein
H7R84_RS21665	COG3385	transposase activity
H7R84_RS21675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R84_RS21680	COG2937	Belongs to the GPAT DAPAT family
H7R84_RS21685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7R84_RS21690	COG3161	chorismate lyase activity
H7R84_RS21710	COG0604	alcohol dehydrogenase
H7R84_RS21715	COG1609	Transcriptional regulator
H7R84_RS21720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R84_RS21735	COG1519	Transferase
H7R84_RS21740	COG0859	PFAM glycosyl transferase family 9
H7R84_RS21750	COG0463	Glycosyl transferase, family 2
H7R84_RS21755	COG0859	PFAM glycosyl transferase family 9
H7R84_RS21760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7R84_RS21765	COG2990	Protein conserved in bacteria
H7R84_RS21770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7R84_RS21780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7R84_RS21785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7R84_RS21790	COG2003	Belongs to the UPF0758 family
H7R84_RS21795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7R84_RS21800	COG0756	dUTP diphosphatase activity
H7R84_RS21805	COG1309	transcriptional regulator
H7R84_RS21810	COG0668	transmembrane transport
H7R84_RS21815	COG0166	Belongs to the GPI family
H7R84_RS21820	COG3385	transposase activity
H7R84_RS21825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7R84_RS21845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R84_RS21845	COG1042	CoA-binding domain protein
H7R84_RS21845	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R84_RS21880	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H7R84_RS21885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R84_RS21890	COG1739	Uncharacterized protein family UPF0029
H7R84_RS21895	COG0006	proline dipeptidase activity
H7R84_RS21900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R84_RS21905	COG1024	Enoyl-CoA hydratase
H7R84_RS21905	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R84_RS21910	COG0183	Belongs to the thiolase family
H7R84_RS21935	COG0425	Belongs to the sulfur carrier protein TusA family
H7R84_RS21940	COG0251	oxidation-reduction process
H7R84_RS21950	COG2885	chlorophyll binding
H7R84_RS21965	COG2818	Glycosylase
H7R84_RS21970	COG0752	glycyl-tRNA synthetase alpha subunit
H7R84_RS21975	COG0751	glycine-tRNA ligase activity
H7R84_RS21985	COG2200	EAL domain
H7R84_RS22010	COG1609	Transcriptional regulator
H7R84_RS22040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R84_RS22055	COG2960	long-chain fatty acid transporting porin activity
H7R84_RS22060	COG5001	Diguanylate cyclase
H7R84_RS22060	COG5002	protein histidine kinase activity
H7R84_RS22070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7R84_RS22085	COG3118	belongs to the thioredoxin family
H7R84_RS22090	COG0513	Belongs to the DEAD box helicase family
H7R84_RS22095	COG0248	Ppx GppA phosphatase
H7R84_RS22105	COG0742	ribosomal rna small subunit methyltransferase
H7R84_RS22120	COG3469	chitinase activity
H7R84_RS22130	COG0084	hydrolase, TatD family'
H7R84_RS22135	COG0805	protein transport
H7R84_RS22140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R84_RS22145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R84_RS22150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7R84_RS22155	COG3165	ubiquinone biosynthetic process from chorismate
H7R84_RS22160	COG2226	methyltransferase
H7R84_RS22165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7R84_RS22170	COG0402	S-adenosylhomocysteine deaminase activity
H7R84_RS22220	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H7R84_RS22225	COG0848	biopolymer transport protein
H7R84_RS22230	COG0811	peptide transport
H7R84_RS22235	COG0811	peptide transport
H7R84_RS22245	COG2771	luxR family
H7R84_RS22260	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7R84_RS22320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7R84_RS22325	COG1349	DNA-binding transcription factor activity
H7R84_RS22330	COG0745	RESPONSE REGULATOR receiver
H7R84_RS22335	COG2205	protein histidine kinase activity
H7R84_RS22345	COG4452	Inner membrane protein CreD
H7R84_RS22350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7R84_RS22355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7R84_RS22360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7R84_RS22365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7R84_RS22370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7R84_RS22375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7R84_RS22380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7R84_RS22390	COG0356	it plays a direct role in the translocation of protons across the membrane
H7R84_RS22400	COG1475	DNA binding
H7R84_RS22405	COG1192	Involved in chromosome partitioning
H7R84_RS22410	COG0357	Ribosomal RNA small subunit methyltransferase G
H7R84_RS22415	COG0445	tRNA wobble uridine modification
H7R84_RS22420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7R84_RS22425	COG4774	siderophore transport
H7R84_RS22430	COG4615	Cyclic peptide transporter
H7R84_RS22435	COG1120	ATPase activity
H7R84_RS22440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R84_RS22445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R84_RS22450	COG3550	peptidyl-serine autophosphorylation
H7R84_RS22480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7R84_RS22490	COG3012	SEC-C Motif Domain Protein
H7R84_RS22490	COG3318	Belongs to the UPF0149 family
H7R84_RS22515	COG3039	Transposase
H7R84_RS22535	COG4974	Belongs to the 'phage' integrase family
H7R84_RS22540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7R84_RS22545	COG0706	membrane insertase activity
H7R84_RS22550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7R84_RS22555	COG0594	ribonuclease P activity
H7R84_RS22560	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7R84_RS22565	COG1126	abc transporter atp-binding protein
H7R84_RS22660	COG4974	Belongs to the 'phage' integrase family
H7R84_RS22860	COG1192	Involved in chromosome partitioning