locus-tag	class	description
H7R74_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7R74_RS00010	COG0592	DNA-directed DNA polymerase activity
H7R74_RS00020	COG0187	DNA topoisomerase II activity
H7R74_RS00030	COG2378	regulation of single-species biofilm formation
H7R74_RS00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7R74_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R74_RS00050	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R74_RS00055	COG3977	Valine--pyruvate aminotransferase
H7R74_RS00070	COG2814	Major facilitator Superfamily
H7R74_RS00075	COG0745	RESPONSE REGULATOR receiver
H7R74_RS00080	COG2205	protein histidine kinase activity
H7R74_RS00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R74_RS00105	COG4191	Histidine kinase
H7R74_RS00105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R74_RS00110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R74_RS00115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R74_RS00120	COG1309	transcriptional regulator
H7R74_RS00150	COG0561	phosphatase activity
H7R74_RS00155	COG2267	carboxylic ester hydrolase activity
H7R74_RS00165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R74_RS00170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R74_RS00175	COG1758	RNA polymerase activity
H7R74_RS00180	COG0194	GDP metabolic process
H7R74_RS00185	COG0859	PFAM glycosyl transferase family 9
H7R74_RS00190	COG3642	lipopolysaccharide core region biosynthetic process
H7R74_RS00230	COG0589	response to stress
H7R74_RS00235	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7R74_RS00240	COG1528	Iron-storage protein
H7R74_RS00245	COG2081	HI0933 family
H7R74_RS00250	COG3275	phosphorelay sensor kinase activity
H7R74_RS00255	COG3279	Response regulator of the LytR AlgR family
H7R74_RS00260	COG2223	nitrite transmembrane transporter activity
H7R74_RS00265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7R74_RS00270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7R74_RS00285	COG0583	DNA-binding transcription factor activity
H7R74_RS00295	COG3385	transposase activity
H7R74_RS00340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7R74_RS00345	COG2166	iron-sulfur cluster assembly
H7R74_RS00350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7R74_RS00365	COG3245	cytochrome
H7R74_RS00370	COG1063	alcohol dehydrogenase
H7R74_RS00385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R74_RS00390	COG0438	transferase activity, transferring glycosyl groups
H7R74_RS00405	COG0110	maltose O-acetyltransferase activity
H7R74_RS00490	COG0210	DNA helicase
H7R74_RS00495	COG1744	ABC transporter substrate-binding protein PnrA-like
H7R74_RS00500	COG3845	ABC transporter
H7R74_RS00505	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7R74_RS00510	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7R74_RS00515	COG0737	Belongs to the 5'-nucleotidase family
H7R74_RS00525	COG2239	Acts as a magnesium transporter
H7R74_RS00530	COG1648	precorrin-2 dehydrogenase activity
H7R74_RS00530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R74_RS00535	COG2116	formate transmembrane transporter activity
H7R74_RS00545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R74_RS00550	COG0842	Transport permease protein
H7R74_RS00555	COG0842	Transport permease protein
H7R74_RS00560	COG1131	(ABC) transporter
H7R74_RS00565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R74_RS00575	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7R74_RS00580	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7R74_RS00590	COG0018	arginyl-trna synthetase
H7R74_RS00600	COG1595	DNA-templated transcription, initiation
H7R74_RS00610	COG1968	undecaprenyl-diphosphatase activity
H7R74_RS00615	COG2017	converts alpha-aldose to the beta-anomer
H7R74_RS00620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7R74_RS00630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R74_RS00635	COG1609	Transcriptional regulator
H7R74_RS00640	COG3250	beta-galactosidase activity
H7R74_RS00650	COG1129	ABC transporter
H7R74_RS00655	COG4211	Belongs to the binding-protein-dependent transport system permease family
H7R74_RS00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R74_RS00680	COG0366	Alpha amylase catalytic
H7R74_RS00695	COG0443	Heat shock 70 kDa protein
H7R74_RS00700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R74_RS00705	COG3045	CreA protein
H7R74_RS00725	COG0174	glutamine synthetase
H7R74_RS00745	COG3842	ATPase activity
H7R74_RS00750	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R74_RS00755	COG1177	transmembrane transport
H7R74_RS00760	COG2258	MOSC domain
H7R74_RS00775	COG2050	protein possibly involved in aromatic compounds catabolism
H7R74_RS00780	COG0514	ATP-dependent DNA helicase (RecQ)
H7R74_RS00790	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7R74_RS00800	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7R74_RS00805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R74_RS00820	COG0254	rRNA binding
H7R74_RS00825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7R74_RS00835	COG0702	epimerase
H7R74_RS00840	COG0814	amino acid
H7R74_RS00845	COG0281	malic enzyme
H7R74_RS00850	COG1295	ribonuclease BN
H7R74_RS00855	COG1490	D-aminoacyl-tRNA deacylase activity
H7R74_RS00860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7R74_RS00865	COG0456	acetyltransferase
H7R74_RS00875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7R74_RS00880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R74_RS00885	COG2610	gluconate transmembrane transporter activity
H7R74_RS00890	COG3265	gluconokinase activity
H7R74_RS00895	COG0129	dihydroxy-acid dehydratase activity
H7R74_RS00900	COG0800	Aldolase
H7R74_RS00905	COG1609	Transcriptional regulator
H7R74_RS00915	COG4942	peptidase
H7R74_RS00920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7R74_RS00925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R74_RS00930	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7R74_RS00935	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7R74_RS00940	COG0316	Belongs to the HesB IscA family
H7R74_RS00940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7R74_RS00945	COG1040	competence protein
H7R74_RS00950	COG0596	Alpha beta hydrolase
H7R74_RS00970	COG2183	response to ionizing radiation
H7R74_RS00975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R74_RS00995	COG0051	transcription antitermination factor activity, RNA binding
H7R74_RS01000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7R74_RS01005	COG0088	Forms part of the polypeptide exit tunnel
H7R74_RS01010	COG0089	rRNA binding
H7R74_RS01015	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7R74_RS01020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7R74_RS01025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7R74_RS01030	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7R74_RS01035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7R74_RS01040	COG0255	Belongs to the universal ribosomal protein uL29 family
H7R74_RS01045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7R74_RS01050	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7R74_RS01055	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7R74_RS01060	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7R74_RS01065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7R74_RS01070	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7R74_RS01075	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7R74_RS01080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7R74_RS01085	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7R74_RS01090	COG1841	ribosomal large subunit assembly
H7R74_RS01095	COG0200	Binds to the 23S rRNA
H7R74_RS01100	COG0201	protein transport
H7R74_RS01105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7R74_RS01110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7R74_RS01115	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7R74_RS01120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7R74_RS01125	COG0202	RNA polymerase activity
H7R74_RS01130	COG0203	ribosomal protein L17
H7R74_RS01160	COG4771	TonB-dependent receptor
H7R74_RS01190	COG0583	DNA-binding transcription factor activity
H7R74_RS01200	COG1741	Belongs to the pirin family
H7R74_RS01205	COG2259	Doxx family
H7R74_RS01210	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7R74_RS01215	COG1074	ATP-dependent DNA helicase activity
H7R74_RS01220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R74_RS01230	COG5433	transposase activity
H7R74_RS01280	COG1175	transmembrane transport
H7R74_RS01290	COG3842	ATPase activity
H7R74_RS01320	COG2873	o-acetylhomoserine
H7R74_RS01330	COG4533	DNA binding
H7R74_RS01350	COG5380	lipid catabolic process
H7R74_RS01355	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7R74_RS01360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R74_RS01385	COG0753	catalase activity
H7R74_RS01415	COG2927	DNA polymerase III (CHI subunit)
H7R74_RS01420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R74_RS01425	COG0795	lipopolysaccharide-transporting ATPase activity
H7R74_RS01430	COG0795	lipopolysaccharide-transporting ATPase activity
H7R74_RS01535	COG1494	fructose-1,6-bisphosphatase
H7R74_RS01550	COG2959	enzyme of heme biosynthesis
H7R74_RS01560	COG0181	hydroxymethylbilane synthase activity
H7R74_RS01565	COG3072	Adenylate cyclase
H7R74_RS01570	COG0400	carboxylic ester hydrolase activity
H7R74_RS01575	COG1965	Belongs to the frataxin family
H7R74_RS01585	COG0019	diaminopimelate decarboxylase activity
H7R74_RS01590	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7R74_RS01605	COG1011	Hydrolase
H7R74_RS01625	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7R74_RS01630	COG3028	Belongs to the UPF0307 family
H7R74_RS01635	COG0312	modulator of DNA gyrase
H7R74_RS01640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7R74_RS01645	COG5007	Belongs to the BolA IbaG family
H7R74_RS01655	COG2854	intermembrane phospholipid transfer
H7R74_RS01660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R74_RS01665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7R74_RS01670	COG1127	ABC transporter
H7R74_RS01675	COG0517	IMP dehydrogenase activity
H7R74_RS01675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7R74_RS01680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7R74_RS01685	COG3117	lipopolysaccharide transmembrane transporter activity
H7R74_RS01690	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7R74_RS01695	COG1137	ATPase activity
H7R74_RS01710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R74_RS01715	COG1660	Displays ATPase and GTPase activities
H7R74_RS01720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R74_RS01740	COG3964	amidohydrolase
H7R74_RS01770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R74_RS01775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R74_RS01785	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7R74_RS01790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7R74_RS01795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7R74_RS01800	COG0723	plastoquinol--plastocyanin reductase activity
H7R74_RS01805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7R74_RS01810	COG2857	Cytochrome c1
H7R74_RS01815	COG0625	glutathione transferase activity
H7R74_RS01820	COG2969	positive regulation of protein catabolic process
H7R74_RS01830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R74_RS01835	COG0792	nuclease activity
H7R74_RS01840	COG3107	peptidoglycan biosynthetic process
H7R74_RS01845	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7R74_RS01855	COG2001	Belongs to the MraZ family
H7R74_RS01860	COG0275	rRNA processing
H7R74_RS01865	COG3116	cell division
H7R74_RS01870	COG0768	penicillin binding
H7R74_RS01880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7R74_RS01885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7R74_RS01890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7R74_RS01895	COG0772	Belongs to the SEDS family
H7R74_RS01900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7R74_RS01905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R74_RS01915	COG0849	cell division
H7R74_RS01920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7R74_RS01925	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7R74_RS01935	COG0653	protein targeting
H7R74_RS01940	COG0494	nUDIX hydrolase
H7R74_RS01945	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H7R74_RS01950	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H7R74_RS01960	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H7R74_RS01965	COG1459	type II secretion system
H7R74_RS01970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R74_RS01995	COG2186	Transcriptional regulator
H7R74_RS02000	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7R74_RS02005	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R74_RS02010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R74_RS02020	COG0840	transmembrane signaling receptor activity
H7R74_RS02025	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R74_RS02030	COG1049	propionate catabolic process, 2-methylcitrate cycle
H7R74_RS02035	COG2200	EAL domain
H7R74_RS02045	COG0523	cobalamin synthesis protein
H7R74_RS02050	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R74_RS02065	COG0477	Major facilitator Superfamily
H7R74_RS02080	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7R74_RS02085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7R74_RS02110	COG3314	Sporulation integral membrane protein YlbJ
H7R74_RS02120	COG0165	Argininosuccinate lyase
H7R74_RS02125	COG0137	argininosuccinate synthase activity
H7R74_RS02135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R74_RS02140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7R74_RS02150	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7R74_RS02155	COG0110	maltose O-acetyltransferase activity
H7R74_RS02165	COG3706	GGDEF domain
H7R74_RS02170	COG0814	amino acid
H7R74_RS02175	COG3932	Exopolysaccharide synthesis, ExoD
H7R74_RS02185	COG3706	GGDEF domain
H7R74_RS02190	COG0004	ammonium transporteR
H7R74_RS02195	COG3133	Outer membrane lipoprotein
H7R74_RS02200	COG0456	acetyltransferase
H7R74_RS02220	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7R74_RS02225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7R74_RS02240	COG0494	nUDIX hydrolase
H7R74_RS02245	COG0628	permease
H7R74_RS02260	COG5433	transposase activity
H7R74_RS02265	COG3284	Transcriptional regulator
H7R74_RS02280	COG1461	Dihydroxyacetone kinase
H7R74_RS02285	COG2376	Dihydroxyacetone kinase
H7R74_RS02290	COG2252	PERMEase
H7R74_RS02295	COG1278	Cold shock
H7R74_RS02300	COG3039	Transposase
H7R74_RS02310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7R74_RS02325	COG1396	sequence-specific DNA binding
H7R74_RS02355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R74_RS02390	COG2197	response regulator
H7R74_RS02425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7R74_RS02430	COG2199	diguanylate cyclase activity
H7R74_RS02435	COG3047	cAMP biosynthetic process
H7R74_RS02440	COG0840	transmembrane signaling receptor activity
H7R74_RS02465	COG3135	benzoate transporter
H7R74_RS02470	COG1396	sequence-specific DNA binding
H7R74_RS02505	COG2926	Belongs to the UPF0265 family
H7R74_RS02515	COG0561	phosphatase activity
H7R74_RS02525	COG1546	Belongs to the CinA family
H7R74_RS02525	COG1058	Belongs to the CinA family
H7R74_RS02535	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H7R74_RS02545	COG1522	sequence-specific DNA binding
H7R74_RS02550	COG1368	sulfuric ester hydrolase activity
H7R74_RS02590	COG4221	oxidoreductase activity
H7R74_RS02605	COG1979	alcohol dehydrogenase
H7R74_RS02610	COG1803	Methylglyoxal synthase
H7R74_RS02630	COG1444	tRNA N-acetyltransferase activity
H7R74_RS02640	COG0835	chemotaxis
H7R74_RS02640	COG0784	Response regulator, receiver
H7R74_RS02650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7R74_RS02655	COG2949	membrane
H7R74_RS02660	COG3291	Pkd domain containing protein
H7R74_RS02665	COG0318	PFAM AMP-dependent synthetase and ligase
H7R74_RS02670	COG1441	menaquinone biosynthetic process
H7R74_RS02675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7R74_RS02680	COG0596	Alpha beta hydrolase
H7R74_RS02685	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H7R74_RS02690	COG1169	isochorismate synthase
H7R74_RS02695	COG1575	Belongs to the MenA family. Type 1 subfamily
H7R74_RS02715	COG0513	Belongs to the DEAD box helicase family
H7R74_RS02720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R74_RS02725	COG1988	membrane-bound metal-dependent
H7R74_RS02730	COG1671	Belongs to the UPF0178 family
H7R74_RS02750	COG0484	heat shock protein binding
H7R74_RS02760	COG3722	fumarate hydratase activity
H7R74_RS02765	COG0246	Mannitol dehydrogenase
H7R74_RS02770	COG2213	PTS system mannitol-specific
H7R74_RS02770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R74_RS02775	COG1560	Kdo2-lipid A biosynthetic process
H7R74_RS02780	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7R74_RS02780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7R74_RS02785	COG1538	Outer membrane efflux protein
H7R74_RS02790	COG0494	nUDIX hydrolase
H7R74_RS02795	COG3151	Protein conserved in bacteria
H7R74_RS02805	COG3150	esterase
H7R74_RS02830	COG3104	oligopeptide transport
H7R74_RS02860	COG2084	Dehydrogenase
H7R74_RS02865	COG0583	DNA-binding transcription factor activity
H7R74_RS02870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R74_RS02890	COG0204	Acyl-transferase
H7R74_RS02895	COG1842	Phage shock protein A
H7R74_RS02910	COG2827	Endonuclease containing a URI domain
H7R74_RS02925	COG1573	uracil-dna glycosylase
H7R74_RS02930	COG0697	spore germination
H7R74_RS02935	COG0583	DNA-binding transcription factor activity
H7R74_RS02940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7R74_RS02945	COG1121	(ABC) transporter
H7R74_RS02950	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H7R74_RS02970	COG0739	heme binding
H7R74_RS02980	COG3068	Protein conserved in bacteria
H7R74_RS03000	COG0617	tRNA 3'-terminal CCA addition
H7R74_RS03005	COG1194	a g-specific adenine glycosylase
H7R74_RS03010	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H7R74_RS03020	COG3111	PFAM Bacterial OB fold (BOF) protein
H7R74_RS03025	COG3240	lipase activity
H7R74_RS03030	COG2885	chlorophyll binding
H7R74_RS03030	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7R74_RS03035	COG3706	GGDEF domain
H7R74_RS03040	COG0557	exoribonuclease II activity
H7R74_RS03045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R74_RS03055	COG2153	protein acetylation
H7R74_RS03060	COG0513	Belongs to the DEAD box helicase family
H7R74_RS03065	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7R74_RS03090	COG0735	belongs to the Fur family
H7R74_RS03095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R74_RS03100	COG0840	transmembrane signaling receptor activity
H7R74_RS03110	COG4166	transmembrane transport
H7R74_RS03120	COG0110	maltose O-acetyltransferase activity
H7R74_RS03130	COG1024	Enoyl-CoA hydratase
H7R74_RS03145	COG4221	oxidoreductase activity
H7R74_RS03150	COG0442	prolyl-tRNA aminoacylation
H7R74_RS03155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R74_RS03165	COG3008	intermembrane lipid transfer
H7R74_RS03165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R74_RS03170	COG2995	paraquat-inducible protein a
H7R74_RS03180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R74_RS03190	COG2203	Gaf domain
H7R74_RS03190	COG4251	negative regulation of phosphorylation
H7R74_RS03190	COG5001	Diguanylate cyclase
H7R74_RS03190	COG3706	GGDEF domain
H7R74_RS03195	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H7R74_RS03210	COG2771	luxR family
H7R74_RS03220	COG0840	transmembrane signaling receptor activity
H7R74_RS03225	COG0632	four-way junction helicase activity
H7R74_RS03230	COG2255	four-way junction helicase activity
H7R74_RS03240	COG1294	oxidase, subunit
H7R74_RS03245	COG4890	Cyd operon protein YbgT
H7R74_RS03250	COG3790	cyd operon protein YbgE
H7R74_RS03255	COG0824	Thioesterase
H7R74_RS03260	COG0811	peptide transport
H7R74_RS03275	COG0823	Involved in the tonB-independent uptake of proteins
H7R74_RS03280	COG2885	chlorophyll binding
H7R74_RS03285	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H7R74_RS03350	COG0733	neurotransmitter:sodium symporter activity
H7R74_RS03360	COG0733	neurotransmitter:sodium symporter activity
H7R74_RS03375	COG0561	phosphatase activity
H7R74_RS03425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7R74_RS03430	COG1640	4-alpha-glucanotransferase
H7R74_RS03435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R74_RS03440	COG0676	glucose-6-phosphate 1-epimerase activity
H7R74_RS03445	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7R74_RS03450	COG0840	transmembrane signaling receptor activity
H7R74_RS03455	COG1585	Membrane protein implicated in regulation of membrane protease activity
H7R74_RS03460	COG0330	HflC and HflK could
H7R74_RS03465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R74_RS03465	COG1648	precorrin-2 dehydrogenase activity
H7R74_RS03470	COG0175	sulfate reduction
H7R74_RS03475	COG2895	sulfate adenylyltransferase (ATP) activity
H7R74_RS03480	COG0471	metal ion transport
H7R74_RS03480	COG3273	potassium ion transport
H7R74_RS03485	COG0529	Catalyzes the synthesis of activated sulfate
H7R74_RS03500	COG5433	transposase activity
H7R74_RS03510	COG0840	transmembrane signaling receptor activity
H7R74_RS03530	COG1136	(ABC) transporter
H7R74_RS03545	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H7R74_RS03560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7R74_RS03565	COG0784	Response regulator, receiver
H7R74_RS03565	COG3437	response regulator, receiver
H7R74_RS03575	COG2076	Multidrug Resistance protein
H7R74_RS03580	COG2076	Multidrug Resistance protein
H7R74_RS03585	COG0346	lactoylglutathione lyase activity
H7R74_RS03590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R74_RS03595	COG1643	Atp-dependent helicase
H7R74_RS03605	COG1489	DNA binding
H7R74_RS03610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7R74_RS03615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R74_RS03625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7R74_RS03630	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7R74_RS03635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7R74_RS03645	COG1823	symporter activity
H7R74_RS03665	COG1924	4 iron, 4 sulfur cluster binding
H7R74_RS03670	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
H7R74_RS03675	COG0842	Transport permease protein
H7R74_RS03680	COG1131	(ABC) transporter
H7R74_RS03695	COG0163	prenyltransferase activity
H7R74_RS03700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R74_RS03705	COG0671	phosphoesterase, PA-phosphatase related
H7R74_RS03710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R74_RS03720	COG1151	hydroxylamine reductase activity
H7R74_RS03725	COG0783	Belongs to the Dps family
H7R74_RS03730	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7R74_RS03735	COG4807	Protein conserved in bacteria
H7R74_RS03745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R74_RS03750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R74_RS03755	COG3956	TIGRFAM MazG family protein
H7R74_RS03760	COG0504	CTP synthase activity
H7R74_RS03765	COG0148	phosphopyruvate hydratase activity
H7R74_RS03810	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7R74_RS03820	COG0488	(ABC) transporter
H7R74_RS03825	COG0617	tRNA 3'-terminal CCA addition
H7R74_RS03825	COG0517	IMP dehydrogenase activity
H7R74_RS03825	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7R74_RS03840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R74_RS03855	COG1794	racemase activity, acting on amino acids and derivatives
H7R74_RS03865	COG2731	YhcH YjgK YiaL family protein
H7R74_RS03875	COG0668	transmembrane transport
H7R74_RS03880	COG1376	ErfK ybiS ycfS ynhG family protein
H7R74_RS03890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R74_RS03895	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7R74_RS03900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7R74_RS03910	COG0585	pseudouridine synthase activity
H7R74_RS03915	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7R74_RS03920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7R74_RS03925	COG1238	metal cluster binding
H7R74_RS03940	COG1902	pentaerythritol trinitrate reductase activity
H7R74_RS03950	COG2852	Protein conserved in bacteria
H7R74_RS03960	COG2957	Belongs to the agmatine deiminase family
H7R74_RS03965	COG0154	amidase activity
H7R74_RS03975	COG3039	Transposase
H7R74_RS03985	COG5433	transposase activity
H7R74_RS04010	COG0513	Belongs to the DEAD box helicase family
H7R74_RS04015	COG2199	diguanylate cyclase activity
H7R74_RS04015	COG2203	Gaf domain
H7R74_RS04025	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
H7R74_RS04030	COG1858	cytochrome C peroxidase
H7R74_RS04110	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7R74_RS04120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R74_RS04125	COG4991	sh3 domain protein
H7R74_RS04135	COG2816	NAD+ diphosphatase activity
H7R74_RS04140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7R74_RS04145	COG1940	carbohydrate kinase activity
H7R74_RS04150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R74_RS04155	COG0126	phosphoglycerate kinase activity
H7R74_RS04160	COG0191	fructose-bisphosphate aldolase activity
H7R74_RS04165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R74_RS04210	COG0354	folic acid binding
H7R74_RS04215	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H7R74_RS04225	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7R74_RS04230	COG1595	DNA-templated transcription, initiation
H7R74_RS04235	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H7R74_RS04240	COG3026	antisigma factor binding
H7R74_RS04250	COG0481	GTPase activity
H7R74_RS04255	COG0681	Belongs to the peptidase S26 family
H7R74_RS04270	COG1381	Involved in DNA repair and RecF pathway recombination
H7R74_RS04275	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7R74_RS04285	COG2350	Protein conserved in bacteria
H7R74_RS04290	COG2917	probably involved in intracellular septation
H7R74_RS04295	COG0076	glutamate decarboxylase activity
H7R74_RS04300	COG1272	protein, Hemolysin III
H7R74_RS04305	COG0569	domain protein
H7R74_RS04305	COG2985	domain, Protein
H7R74_RS04325	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
H7R74_RS04335	COG0653	protein targeting
H7R74_RS04380	COG4974	Belongs to the 'phage' integrase family
H7R74_RS04410	COG0582	viral genome integration into host DNA
H7R74_RS04430	COG1858	cytochrome C peroxidase
H7R74_RS04440	COG2313	pseudouridylate synthase activity
H7R74_RS04445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R74_RS04485	COG1765	OsmC-like protein
H7R74_RS04500	COG3954	Phosphoribulokinase
H7R74_RS04505	COG3089	Belongs to the UPF0270 family
H7R74_RS04510	COG2203	Gaf domain
H7R74_RS04510	COG3706	GGDEF domain
H7R74_RS04510	COG5001	Diguanylate cyclase
H7R74_RS04510	COG4251	negative regulation of phosphorylation
H7R74_RS04515	COG0429	hydrolase of the alpha beta-hydrolase fold
H7R74_RS04520	COG0784	Response regulator, receiver
H7R74_RS04520	COG0835	chemotaxis
H7R74_RS04530	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H7R74_RS04535	COG1047	Peptidyl-prolyl cis-trans
H7R74_RS04550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R74_RS04565	COG1966	Carbon starvation protein
H7R74_RS04570	COG3279	Response regulator of the LytR AlgR family
H7R74_RS04575	COG3275	phosphorelay sensor kinase activity
H7R74_RS04590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R74_RS04600	COG3721	Heme iron utilization protein
H7R74_RS04605	COG0748	coenzyme F420 binding
H7R74_RS04630	COG2814	Major facilitator Superfamily
H7R74_RS04640	COG3655	Transcriptional regulator
H7R74_RS04650	COG0784	Response regulator, receiver
H7R74_RS04650	COG2205	protein histidine kinase activity
H7R74_RS04650	COG5002	protein histidine kinase activity
H7R74_RS04660	COG3706	GGDEF domain
H7R74_RS04675	COG3397	chitin binding
H7R74_RS04700	COG0835	chemotaxis
H7R74_RS04700	COG0784	Response regulator, receiver
H7R74_RS04705	COG2755	lipolytic protein G-D-S-L family
H7R74_RS04710	COG4181	ATPase activity
H7R74_RS04715	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H7R74_RS04720	COG1090	epimerase
H7R74_RS04725	COG2200	EAL domain
H7R74_RS04730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R74_RS04735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7R74_RS04740	COG3171	Protein conserved in bacteria
H7R74_RS04745	COG2066	Belongs to the glutaminase family
H7R74_RS04750	COG2897	thiosulfate sulfurtransferase activity
H7R74_RS04765	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R74_RS04775	COG2966	Psort location CytoplasmicMembrane, score
H7R74_RS04780	COG3610	response to peptide
H7R74_RS04795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R74_RS04800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7R74_RS04805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7R74_RS04820	COG0786	glutamate:sodium symporter activity
H7R74_RS04825	COG0252	asparaginase activity
H7R74_RS04830	COG3139	Protein of unknown function (DUF1315)
H7R74_RS04850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7R74_RS04855	COG0321	lipoyl(octanoyl) transferase activity
H7R74_RS04860	COG2921	Belongs to the UPF0250 family
H7R74_RS04865	COG1686	Belongs to the peptidase S11 family
H7R74_RS04870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7R74_RS04875	COG2951	lytic endotransglycosylase activity
H7R74_RS04880	COG0772	Belongs to the SEDS family
H7R74_RS04885	COG0768	penicillin binding
H7R74_RS04890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7R74_RS04895	COG0799	negative regulation of ribosome biogenesis
H7R74_RS04900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7R74_RS04915	COG0495	leucyl-tRNA aminoacylation
H7R74_RS04920	COG2888	peptidyl-tyrosine sulfation
H7R74_RS04925	COG0312	modulator of DNA gyrase
H7R74_RS04935	COG0716	FMN binding
H7R74_RS04940	COG4974	Belongs to the 'phage' integrase family
H7R74_RS04945	COG1970	mechanosensitive ion channel activity
H7R74_RS04960	COG0789	Transcriptional regulator
H7R74_RS04965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7R74_RS04970	COG4535	Mg2 and Co2 transporter CorC
H7R74_RS04975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7R74_RS04980	COG1702	phosphate starvation-inducible protein PhoH
H7R74_RS04985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R74_RS04990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R74_RS04995	COG1335	isochorismatase
H7R74_RS05000	COG1278	Cold shock
H7R74_RS05005	COG3706	GGDEF domain
H7R74_RS05010	COG0583	DNA-binding transcription factor activity
H7R74_RS05030	COG3447	MASE1 domain protein
H7R74_RS05030	COG5002	protein histidine kinase activity
H7R74_RS05030	COG5001	Diguanylate cyclase
H7R74_RS05040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R74_RS05050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7R74_RS05060	COG0516	GMP reductase activity
H7R74_RS05070	COG0642	Histidine kinase
H7R74_RS05085	COG4221	oxidoreductase activity
H7R74_RS05110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R74_RS05125	COG3214	Protein conserved in bacteria
H7R74_RS05135	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R74_RS05140	COG0700	Nucleoside recognition
H7R74_RS05145	COG3366	ferrous iron transmembrane transporter activity
H7R74_RS05150	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R74_RS05155	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R74_RS05160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7R74_RS05165	COG1053	succinate dehydrogenase
H7R74_RS05175	COG0584	glycerophosphoryl diester phosphodiesterase
H7R74_RS05180	COG1511	domain protein
H7R74_RS05180	COG3264	Mechanosensitive ion channel
H7R74_RS05190	COG0739	heme binding
H7R74_RS05200	COG0583	DNA-binding transcription factor activity
H7R74_RS05225	COG0583	DNA-binding transcription factor activity
H7R74_RS05230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7R74_RS05260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7R74_RS05265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7R74_RS05275	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H7R74_RS05280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7R74_RS05290	COG0180	Tryptophanyl-tRNA synthetase
H7R74_RS05300	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R74_RS05305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7R74_RS05315	COG1012	belongs to the aldehyde dehydrogenase family
H7R74_RS05330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R74_RS05345	COG2369	cell adhesion
H7R74_RS05350	COG4383	Mu-like prophage protein gp29
H7R74_RS05410	COG4396	Host-nuclease inhibitor protein Gam
H7R74_RS05620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R74_RS05620	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7R74_RS05620	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7R74_RS05620	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7R74_RS05625	COG0366	Alpha amylase catalytic
H7R74_RS05635	COG0657	acetylesterase activity
H7R74_RS05650	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H7R74_RS05660	COG0490	domain, Protein
H7R74_RS05660	COG0471	metal ion transport
H7R74_RS05705	COG0012	GTP binding
H7R74_RS05710	COG0193	aminoacyl-tRNA hydrolase activity
H7R74_RS05715	COG0737	Belongs to the 5'-nucleotidase family
H7R74_RS05720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7R74_RS05730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7R74_RS05735	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H7R74_RS05740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7R74_RS05745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7R74_RS05750	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R74_RS05760	COG2912	Transglutaminase-like superfamily
H7R74_RS05765	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7R74_RS05770	COG1301	dicarboxylic acid transport
H7R74_RS05785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7R74_RS05795	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H7R74_RS05795	COG3408	Glycogen debranching enzyme
H7R74_RS05805	COG1881	PFAM PEBP family protein
H7R74_RS05810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7R74_RS05825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7R74_RS05835	COG0583	DNA-binding transcription factor activity
H7R74_RS05840	COG1028	Short-chain dehydrogenase reductase Sdr
H7R74_RS05845	COG0616	signal peptide processing
H7R74_RS05850	COG2211	Major facilitator Superfamily
H7R74_RS05855	COG3706	GGDEF domain
H7R74_RS05860	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R74_RS05870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R74_RS05875	COG0826	peptidase U32
H7R74_RS05880	COG2199	diguanylate cyclase activity
H7R74_RS05880	COG2200	EAL domain
H7R74_RS05880	COG2203	Gaf domain
H7R74_RS05895	COG5433	transposase activity
H7R74_RS05915	COG5433	transposase activity
H7R74_RS05920	COG2197	response regulator
H7R74_RS05940	COG3724	N-succinylarginine dihydrolase activity
H7R74_RS05960	COG0840	transmembrane signaling receptor activity
H7R74_RS05970	COG2971	BadF BadG BcrA BcrD
H7R74_RS05980	COG4608	Belongs to the ABC transporter superfamily
H7R74_RS05985	COG0444	Belongs to the ABC transporter superfamily
H7R74_RS05990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R74_RS06005	COG0784	Response regulator, receiver
H7R74_RS06005	COG2205	protein histidine kinase activity
H7R74_RS06035	COG3220	belongs to the UPF0276 family
H7R74_RS06065	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R74_RS06070	COG1289	transmembrane transporter activity
H7R74_RS06075	COG0303	'Molybdopterin
H7R74_RS06080	COG0746	molybdenum cofactor guanylyltransferase activity
H7R74_RS06090	COG4662	Binding-protein-dependent transport system inner membrane component
H7R74_RS06100	COG2204	response regulator
H7R74_RS06105	COG3852	Histidine kinase
H7R74_RS06115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7R74_RS06150	COG3383	formate dehydrogenase (NAD+) activity
H7R74_RS06150	COG3383	formate dehydrogenase (NAD+) activity
H7R74_RS06155	COG0437	4 iron, 4 sulfur cluster binding
H7R74_RS06175	COG0281	malic enzyme
H7R74_RS06195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R74_RS06225	COG0837	glucose binding
H7R74_RS06230	COG1737	Transcriptional regulator
H7R74_RS06235	COG0469	pyruvate kinase activity
H7R74_RS06255	COG1677	Flagellar hook-basal body complex protein FliE
H7R74_RS06265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7R74_RS06315	COG1987	bacterial-type flagellum assembly
H7R74_RS06320	COG1684	flagellar biosynthetic protein fliR
H7R74_RS06330	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7R74_RS06355	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H7R74_RS06360	COG2198	Histidine kinase
H7R74_RS06360	COG0643	Histidine kinase
H7R74_RS06360	COG0784	Response regulator, receiver
H7R74_RS06365	COG2201	protein-glutamate methylesterase activity
H7R74_RS06370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R74_RS06375	COG1360	Flagellar Motor Protein
H7R74_RS06380	COG1192	Involved in chromosome partitioning
H7R74_RS06390	COG0835	chemotaxis
H7R74_RS06405	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R74_RS06410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R74_RS06415	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R74_RS06420	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7R74_RS06425	COG1138	Cytochrome C-type biogenesis protein
H7R74_RS06430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R74_RS06445	COG2853	Lipoprotein
H7R74_RS06455	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7R74_RS06460	COG3039	Transposase
H7R74_RS06470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R74_RS06475	COG1882	Formate acetyltransferase
H7R74_RS06485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R74_RS06485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R74_RS06495	COG3039	Transposase
H7R74_RS06510	COG0259	pyridoxamine-phosphate oxidase activity
H7R74_RS06515	COG0625	glutathione transferase activity
H7R74_RS06535	COG2850	peptidyl-arginine hydroxylation
H7R74_RS06540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7R74_RS06545	COG2915	High frequency lysogenization protein hflD homolog
H7R74_RS06550	COG0482	sulfurtransferase activity
H7R74_RS06560	COG1187	pseudouridine synthase activity
H7R74_RS06570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R74_RS06575	COG2271	Major facilitator Superfamily
H7R74_RS06580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R74_RS06580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R74_RS06580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R74_RS06600	COG5433	transposase activity
H7R74_RS06610	COG4821	SIS domain
H7R74_RS06615	COG3385	transposase activity
H7R74_RS06635	COG1609	Transcriptional regulator
H7R74_RS06640	COG1263	PTS System
H7R74_RS06640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R74_RS06645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7R74_RS06655	COG5433	transposase activity
H7R74_RS06670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7R74_RS06680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R74_RS06685	COG1960	acyl-CoA dehydrogenase activity
H7R74_RS06695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7R74_RS06710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R74_RS06710	COG2205	protein histidine kinase activity
H7R74_RS06720	COG3039	Transposase
H7R74_RS06735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7R74_RS06740	COG2867	negative regulation of translational initiation
H7R74_RS06745	COG2914	Belongs to the UPF0125 (RnfH) family
H7R74_RS06750	COG1473	amidohydrolase
H7R74_RS06755	COG1960	acyl-CoA dehydrogenase activity
H7R74_RS06760	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R74_RS06765	COG0121	glutamine amidotransferase
H7R74_RS06795	COG2197	response regulator
H7R74_RS06800	COG3850	Histidine kinase
H7R74_RS06805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7R74_RS06810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R74_RS06820	COG0243	molybdopterin cofactor binding
H7R74_RS06825	COG0437	4 iron, 4 sulfur cluster binding
H7R74_RS06830	COG0348	domain, Protein
H7R74_RS06840	COG3005	denitrification pathway
H7R74_RS06845	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R74_RS06850	COG0315	cyclic pyranopterin monophosphate synthase activity
H7R74_RS06855	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7R74_RS06860	COG0314	molybdopterin synthase activity
H7R74_RS06875	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7R74_RS06885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R74_RS06895	COG0302	gtp cyclohydrolase
H7R74_RS06900	COG0840	transmembrane signaling receptor activity
H7R74_RS06905	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H7R74_RS06915	COG0583	DNA-binding transcription factor activity
H7R74_RS06920	COG2353	YceI-like domain
H7R74_RS06930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7R74_RS06945	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R74_RS06950	COG1166	arginine decarboxylase activity
H7R74_RS06970	COG0814	amino acid
H7R74_RS06980	COG3681	Belongs to the UPF0597 family
H7R74_RS06985	COG2964	Protein conserved in bacteria
H7R74_RS07000	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7R74_RS07005	COG1288	antiporter activity
H7R74_RS07010	COG0436	Aminotransferase
H7R74_RS07020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R74_RS07025	COG1196	nuclear chromosome segregation
H7R74_RS07025	COG0739	heme binding
H7R74_RS07025	COG0741	lytic transglycosylase activity
H7R74_RS07040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R74_RS07050	COG0788	formyltetrahydrofolate deformylase activity
H7R74_RS07055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R74_RS07065	COG3118	belongs to the thioredoxin family
H7R74_RS07075	COG0791	NLP P60 protein
H7R74_RS07080	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H7R74_RS07090	COG0471	metal ion transport
H7R74_RS07100	COG1376	ErfK ybiS ycfS ynhG family protein
H7R74_RS07100	COG1388	LysM domain
H7R74_RS07110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R74_RS07115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R74_RS07120	COG0745	RESPONSE REGULATOR receiver
H7R74_RS07125	COG5002	protein histidine kinase activity
H7R74_RS07150	COG0741	lytic transglycosylase activity
H7R74_RS07150	COG1388	LysM domain
H7R74_RS07155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R74_RS07160	COG2226	methyltransferase
H7R74_RS07165	COG0328	RNA-DNA hybrid ribonuclease activity
H7R74_RS07170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R74_RS07185	COG5433	transposase activity
H7R74_RS07195	COG2375	cellular response to nickel ion
H7R74_RS07200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R74_RS07205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R74_RS07210	COG1120	ATPase activity
H7R74_RS07215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R74_RS07225	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R74_RS07230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R74_RS07265	COG0708	Exodeoxyribonuclease III
H7R74_RS07295	COG3132	Protein of unknown function, DUF480
H7R74_RS07300	COG3300	MHYT domain
H7R74_RS07300	COG5001	Diguanylate cyclase
H7R74_RS07310	COG2841	Protein conserved in bacteria
H7R74_RS07320	COG0534	Mate efflux family protein
H7R74_RS07355	COG1309	transcriptional regulator
H7R74_RS07390	COG3152	Membrane
H7R74_RS07405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R74_RS07410	COG3537	Alpha-1,2-mannosidase
H7R74_RS07415	COG5433	transposase activity
H7R74_RS07430	COG3537	Alpha-1,2-mannosidase
H7R74_RS07440	COG2207	Transcriptional regulator
H7R74_RS07455	COG0538	isocitrate dehydrogenase activity
H7R74_RS07465	COG3048	D-serine ammonia-lyase activity
H7R74_RS07470	COG2610	gluconate transmembrane transporter activity
H7R74_RS07475	COG0583	DNA-binding transcription factor activity
H7R74_RS07485	COG0791	NLP P60 protein
H7R74_RS07490	COG0583	DNA-binding transcription factor activity
H7R74_RS07495	COG0450	alkyl hydroperoxide reductase
H7R74_RS07515	COG0500	methyltransferase
H7R74_RS07520	COG4106	trans-aconitate 2-methyltransferase activity
H7R74_RS07525	COG1801	Protein of unknown function DUF72
H7R74_RS07535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7R74_RS07540	COG0217	transcriptional regulatory protein
H7R74_RS07545	COG1454	alcohol dehydrogenase
H7R74_RS07545	COG1012	belongs to the aldehyde dehydrogenase family
H7R74_RS07550	COG2095	MarC family integral membrane protein
H7R74_RS07560	COG0601	transmembrane transport
H7R74_RS07565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R74_RS07580	COG0861	Integral membrane protein TerC family
H7R74_RS07585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R74_RS07615	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H7R74_RS07620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R74_RS07625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7R74_RS07630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R74_RS07635	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7R74_RS07640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7R74_RS07655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7R74_RS07665	COG0505	Belongs to the CarA family
H7R74_RS07670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7R74_RS07680	COG1605	Chorismate mutase
H7R74_RS07680	COG0287	Prephenate dehydrogenase
H7R74_RS07685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R74_RS07695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R74_RS07700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R74_RS07735	COG0537	adenosine 5'-monophosphoramidase activity
H7R74_RS07750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7R74_RS07765	COG1301	dicarboxylic acid transport
H7R74_RS07780	COG2354	Protein conserved in bacteria
H7R74_RS07790	COG2233	PERMEase
H7R74_RS07795	COG3150	esterase
H7R74_RS07800	COG1252	NADH dehydrogenase
H7R74_RS07810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R74_RS07815	COG5001	Diguanylate cyclase
H7R74_RS07815	COG3300	MHYT domain
H7R74_RS07820	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R74_RS07830	COG2373	Large extracellular alpha-helical protein
H7R74_RS07835	COG4953	penicillin-binding protein 1C
H7R74_RS07845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R74_RS07845	COG0301	tRNA thio-modification
H7R74_RS07865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7R74_RS07895	COG2089	acid synthase
H7R74_RS07905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H7R74_RS07915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7R74_RS07920	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7R74_RS07930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7R74_RS07935	COG1086	Polysaccharide biosynthesis protein
H7R74_RS07940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R74_RS07950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7R74_RS07960	COG0483	inositol monophosphate 1-phosphatase activity
H7R74_RS07970	COG0625	glutathione transferase activity
H7R74_RS07975	COG2814	Major facilitator Superfamily
H7R74_RS07995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R74_RS08000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R74_RS08005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7R74_RS08010	COG0509	glycine decarboxylation via glycine cleavage system
H7R74_RS08015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R74_RS08015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R74_RS08035	COG3318	Belongs to the UPF0149 family
H7R74_RS08035	COG3012	SEC-C Motif Domain Protein
H7R74_RS08040	COG0714	Associated with various cellular activities
H7R74_RS08050	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7R74_RS08090	COG5642	Protein of unknown function (DUF2384)
H7R74_RS08095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R74_RS08105	COG3039	Transposase
H7R74_RS08140	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7R74_RS08145	COG0574	Belongs to the PEP-utilizing enzyme family
H7R74_RS08145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7R74_RS08160	COG1464	Belongs to the NlpA lipoprotein family
H7R74_RS08165	COG3083	sulfuric ester hydrolase activity
H7R74_RS08170	COG3082	Protein of unknown function (DUF1414)
H7R74_RS08175	COG3081	Nucleoid-associated protein
H7R74_RS08185	COG1175	transmembrane transport
H7R74_RS08190	COG3833	ABC-type maltose transport systems, permease component
H7R74_RS08195	COG3842	ATPase activity
H7R74_RS08220	COG0425	Belongs to the sulfur carrier protein TusA family
H7R74_RS08225	COG4783	chaperone-mediated protein folding
H7R74_RS08230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R74_RS08235	COG1393	Belongs to the ArsC family
H7R74_RS08245	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H7R74_RS08250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R74_RS08255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R74_RS08260	COG2431	L-lysine efflux transmembrane transporter activity
H7R74_RS08270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R74_RS08280	COG4160	amino acid transport
H7R74_RS08285	COG0564	pseudouridine synthase activity
H7R74_RS08300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7R74_RS08310	COG0625	glutathione transferase activity
H7R74_RS08335	COG0642	Histidine kinase
H7R74_RS08340	COG2261	transglycosylase associated protein
H7R74_RS08355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R74_RS08365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R74_RS08370	COG0215	cysteine-tRNA ligase activity
H7R74_RS08380	COG1106	Psort location Cytoplasmic, score
H7R74_RS08415	COG2119	membrane
H7R74_RS08420	COG0023	Translation Initiation Factor
H7R74_RS08445	COG0513	Belongs to the DEAD box helicase family
H7R74_RS08455	COG0493	'glutamate synthase
H7R74_RS08460	COG0067	glutamate synthase
H7R74_RS08460	COG0069	glutamate synthase activity
H7R74_RS08460	COG0070	glutamate synthase
H7R74_RS08465	COG1242	4 iron, 4 sulfur cluster binding
H7R74_RS08520	COG3634	alkyl hydroperoxide reductase activity
H7R74_RS08530	COG0517	IMP dehydrogenase activity
H7R74_RS08535	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7R74_RS08540	COG0343	queuine tRNA-ribosyltransferase activity
H7R74_RS08545	COG1862	Preprotein translocase
H7R74_RS08550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R74_RS08555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R74_RS08570	COG0826	peptidase U32
H7R74_RS08575	COG0826	peptidase U32
H7R74_RS08580	COG3154	lipid carrier protein
H7R74_RS08600	COG1104	cysteine desulfurase activity
H7R74_RS08605	COG0822	iron-sulfur transferase activity
H7R74_RS08615	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R74_RS08620	COG0443	Heat shock 70 kDa protein
H7R74_RS08625	COG0633	Ferredoxin
H7R74_RS08640	COG0105	UTP biosynthetic process
H7R74_RS08645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7R74_RS08660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7R74_RS08665	COG0124	histidyl-tRNA synthetase
H7R74_RS08670	COG2976	Protein conserved in bacteria
H7R74_RS08675	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R74_RS08680	COG1160	GTP binding
H7R74_RS08685	COG1645	bacterial-type flagellum-dependent swarming motility
H7R74_RS08690	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R74_RS08695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7R74_RS08695	COG0047	phosphoribosylformylglycinamidine synthase activity
H7R74_RS08700	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R74_RS08700	COG2199	diguanylate cyclase activity
H7R74_RS08715	COG1007	ATP synthesis coupled electron transport
H7R74_RS08720	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R74_RS08730	COG0713	ATP synthesis coupled electron transport
H7R74_RS08735	COG0839	Belongs to the complex I subunit 6 family
H7R74_RS08740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R74_RS08745	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7R74_RS08750	COG1034	ATP synthesis coupled electron transport
H7R74_RS08765	COG0649	NAD binding
H7R74_RS08765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R74_RS08770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R74_RS08775	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R74_RS08795	COG1770	oligopeptidase
H7R74_RS08800	COG4771	TonB-dependent receptor
H7R74_RS08805	COG1360	Flagellar Motor Protein
H7R74_RS08810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R74_RS08840	COG5642	Protein of unknown function (DUF2384)
H7R74_RS08900	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H7R74_RS08910	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H7R74_RS08915	COG4597	amino acid ABC transporter
H7R74_RS08920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R74_RS08925	COG0765	amino acid transport
H7R74_RS08930	COG1126	abc transporter atp-binding protein
H7R74_RS08940	COG0724	RNA recognition motif
H7R74_RS08945	COG4989	oxidoreductase activity
H7R74_RS08970	COG3437	response regulator, receiver
H7R74_RS08975	COG0583	DNA-binding transcription factor activity
H7R74_RS08980	COG3039	Transposase
H7R74_RS08985	COG3300	MHYT domain
H7R74_RS08985	COG5001	Diguanylate cyclase
H7R74_RS08990	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H7R74_RS09000	COG3385	transposase activity
H7R74_RS09020	COG2814	Major facilitator Superfamily
H7R74_RS09035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R74_RS09040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7R74_RS09045	COG0539	negative regulation of cytoplasmic translation
H7R74_RS09050	COG0776	regulation of translation
H7R74_RS09060	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7R74_RS09080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7R74_RS09085	COG0602	queuosine metabolic process
H7R74_RS09090	COG3530	Putative quorum-sensing-regulated virulence factor
H7R74_RS09095	COG2096	Adenosyltransferase
H7R74_RS09100	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R74_RS09105	COG1757	Na H antiporter
H7R74_RS09110	COG1435	thymidine kinase activity
H7R74_RS09160	COG5433	transposase activity
H7R74_RS09185	COG3039	Transposase
H7R74_RS09190	COG0583	DNA-binding transcription factor activity
H7R74_RS09210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7R74_RS09215	COG0326	Molecular chaperone. Has ATPase activity
H7R74_RS09220	COG4172	Belongs to the ABC transporter superfamily
H7R74_RS09225	COG4172	Belongs to the ABC transporter superfamily
H7R74_RS09235	COG4168	peptide transport system, permease
H7R74_RS09245	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7R74_RS09250	COG1842	Phage shock protein A
H7R74_RS09265	COG3106	COG3106 Predicted ATPase
H7R74_RS09270	COG3768	UPF0283 membrane protein
H7R74_RS09275	COG0583	DNA-binding transcription factor activity
H7R74_RS09280	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7R74_RS09285	COG3842	ATPase activity
H7R74_RS09290	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R74_RS09295	COG1177	transmembrane transport
H7R74_RS09300	COG1012	belongs to the aldehyde dehydrogenase family
H7R74_RS09310	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7R74_RS09330	COG2885	chlorophyll binding
H7R74_RS09335	COG0861	Integral membrane protein TerC family
H7R74_RS09365	COG2910	NAD(P)H-binding
H7R74_RS09370	COG0583	DNA-binding transcription factor activity
H7R74_RS09375	COG0583	DNA-binding transcription factor activity
H7R74_RS09380	COG2271	Major facilitator Superfamily
H7R74_RS09390	COG1335	isochorismatase
H7R74_RS09400	COG0583	DNA-binding transcription factor activity
H7R74_RS09405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7R74_RS09415	COG0583	DNA-binding transcription factor activity
H7R74_RS09420	COG2723	6-phospho-beta-galactosidase activity
H7R74_RS09430	COG0583	DNA-binding transcription factor activity
H7R74_RS09435	COG1944	ATP diphosphatase activity
H7R74_RS09440	COG2116	formate transmembrane transporter activity
H7R74_RS09445	COG1882	Formate acetyltransferase
H7R74_RS09450	COG2983	Belongs to the UPF0260 family
H7R74_RS09465	COG0058	SHG alpha-glucan phosphorylase activity
H7R74_RS09470	COG0471	metal ion transport
H7R74_RS09475	COG3118	belongs to the thioredoxin family
H7R74_RS09485	COG1132	(ABC) transporter
H7R74_RS09490	COG1132	(ABC) transporter
H7R74_RS09500	COG2501	S4 domain
H7R74_RS09515	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7R74_RS09560	COG2009	succinate dehydrogenase
H7R74_RS09565	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7R74_RS09570	COG1053	succinate dehydrogenase
H7R74_RS09580	COG0567	Dehydrogenase, E1 component
H7R74_RS09585	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R74_RS09590	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R74_RS09605	COG1584	GPR1 FUN34 yaaH family protein
H7R74_RS09635	COG1024	Enoyl-CoA hydratase
H7R74_RS09640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7R74_RS09645	COG1960	acyl-CoA dehydrogenase activity
H7R74_RS09650	COG1960	acyl-CoA dehydrogenase activity
H7R74_RS09655	COG1024	Enoyl-CoA hydratase
H7R74_RS09660	COG1024	Enoyl-CoA hydratase
H7R74_RS09670	COG1028	Short-chain dehydrogenase reductase Sdr
H7R74_RS09680	COG0730	response to heat
H7R74_RS09755	COG2003	Belongs to the UPF0758 family
H7R74_RS09775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R74_RS09800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R74_RS09805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R74_RS09810	COG3046	protein related to deoxyribodipyrimidine photolyase
H7R74_RS09820	COG3033	Beta-eliminating lyase
H7R74_RS09825	COG0295	cytidine deaminase activity
H7R74_RS09830	COG1346	cytolysis
H7R74_RS09835	COG1380	Effector of murein hydrolase LrgA
H7R74_RS09840	COG3345	alpha-galactosidase
H7R74_RS09850	COG2925	Exonuclease
H7R74_RS09915	COG0641	radical SAM
H7R74_RS09945	COG2304	oxidoreductase activity
H7R74_RS09970	COG3119	arylsulfatase activity
H7R74_RS09975	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R74_RS09980	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7R74_RS09980	COG0617	tRNA 3'-terminal CCA addition
H7R74_RS09980	COG0517	IMP dehydrogenase activity
H7R74_RS09985	COG1643	Atp-dependent helicase
H7R74_RS09995	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7R74_RS10010	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7R74_RS10015	COG2067	long-chain fatty acid transport protein
H7R74_RS10020	COG2067	long-chain fatty acid transport protein
H7R74_RS10030	COG1595	DNA-templated transcription, initiation
H7R74_RS10040	COG2304	oxidoreductase activity
H7R74_RS10060	COG0714	Associated with various cellular activities
H7R74_RS10065	COG0183	Belongs to the thiolase family
H7R74_RS10070	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R74_RS10070	COG1024	Enoyl-CoA hydratase
H7R74_RS10075	COG2719	SpoVR family
H7R74_RS10080	COG2718	Belongs to the UPF0229 family
H7R74_RS10085	COG2766	serine protein kinase
H7R74_RS10090	COG0514	ATP-dependent DNA helicase (RecQ)
H7R74_RS10095	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H7R74_RS10105	COG0814	amino acid
H7R74_RS10110	COG0494	nUDIX hydrolase
H7R74_RS10125	COG2824	Alkylphosphonate utilization operon protein PhnA
H7R74_RS10145	COG3706	GGDEF domain
H7R74_RS10150	COG2840	Smr protein MutS2
H7R74_RS10155	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R74_RS10160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7R74_RS10170	COG0513	Belongs to the DEAD box helicase family
H7R74_RS10180	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H7R74_RS10190	COG0814	amino acid
H7R74_RS10195	COG1609	Transcriptional regulator
H7R74_RS10200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R74_RS10200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R74_RS10205	COG1105	Belongs to the carbohydrate kinase PfkB family
H7R74_RS10210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R74_RS10210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R74_RS10210	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H7R74_RS10215	COG1530	ribonuclease E activity
H7R74_RS10230	COG0424	maF-like protein
H7R74_RS10235	COG1399	metal-binding, possibly nucleic acid-binding protein
H7R74_RS10240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7R74_RS10245	COG0416	fatty acid biosynthetic process
H7R74_RS10250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R74_RS10260	COG1028	Short-chain dehydrogenase reductase Sdr
H7R74_RS10265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7R74_RS10270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7R74_RS10275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7R74_RS10280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7R74_RS10285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7R74_RS10290	COG0470	DNA polymerase III
H7R74_RS10295	COG0084	hydrolase, TatD family'
H7R74_RS10310	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H7R74_RS10310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R74_RS10315	COG3008	intermembrane lipid transfer
H7R74_RS10320	COG2995	paraquat-inducible protein a
H7R74_RS10330	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7R74_RS10335	COG0372	Belongs to the citrate synthase family
H7R74_RS10380	COG4221	oxidoreductase activity
H7R74_RS10385	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7R74_RS10390	COG3141	response to X-ray
H7R74_RS10415	COG1067	ATP-dependent peptidase activity
H7R74_RS10420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R74_RS10430	COG0488	(ABC) transporter
H7R74_RS10440	COG0116	Belongs to the methyltransferase superfamily
H7R74_RS10440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R74_RS10445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7R74_RS10450	COG0254	rRNA binding
H7R74_RS10465	COG0167	dihydroorotate dehydrogenase activity
H7R74_RS10470	COG2902	Dehydrogenase
H7R74_RS10480	COG0308	aminopeptidase N
H7R74_RS10490	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H7R74_RS10495	COG1956	GAF domain-containing protein
H7R74_RS10505	COG3278	Belongs to the heme-copper respiratory oxidase family
H7R74_RS10520	COG2010	Cytochrome c
H7R74_RS10530	COG2217	Heavy metal translocating P-type atpase
H7R74_RS10545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R74_RS10550	COG0589	response to stress
H7R74_RS10555	COG0037	tRNA processing
H7R74_RS10580	COG1177	transmembrane transport
H7R74_RS10605	COG1869	D-ribose catabolic process
H7R74_RS10610	COG1129	ABC transporter
H7R74_RS10615	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7R74_RS10620	COG1879	ABC-type sugar transport system periplasmic component
H7R74_RS10625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R74_RS10630	COG1609	Transcriptional regulator
H7R74_RS10635	COG3706	GGDEF domain
H7R74_RS10660	COG2205	protein histidine kinase activity
H7R74_RS10660	COG0784	Response regulator, receiver
H7R74_RS10665	COG0776	regulation of translation
H7R74_RS10670	COG0072	phenylalanine-tRNA ligase activity
H7R74_RS10670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R74_RS10675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7R74_RS10680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7R74_RS10685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7R74_RS10690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7R74_RS10695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7R74_RS10715	COG0366	Alpha amylase catalytic
H7R74_RS10725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R74_RS10735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R74_RS10740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R74_RS10745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R74_RS10750	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H7R74_RS10755	COG3313	Fe-S protein
H7R74_RS10760	COG2942	2-epimerase
H7R74_RS10765	COG3716	PTS system mannose fructose sorbose family IID component
H7R74_RS10770	COG3715	PTS system
H7R74_RS10775	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R74_RS10775	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R74_RS10790	COG1609	Transcriptional regulator
H7R74_RS10795	COG2140	Oxalate decarboxylase
H7R74_RS10800	COG0306	phosphate transporter
H7R74_RS10805	COG0717	Belongs to the dCTP deaminase family
H7R74_RS10810	COG0572	uridine kinase
H7R74_RS10815	COG0489	protein tyrosine kinase activity
H7R74_RS10820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R74_RS10820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R74_RS10830	COG1254	Belongs to the acylphosphatase family
H7R74_RS10840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7R74_RS10845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R74_RS10860	COG0709	Synthesizes selenophosphate from selenide and ATP
H7R74_RS10865	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H7R74_RS10870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R74_RS10885	COG0318	PFAM AMP-dependent synthetase and ligase
H7R74_RS10890	COG2267	carboxylic ester hydrolase activity
H7R74_RS10900	COG1214	PFAM Peptidase M22, glycoprotease
H7R74_RS10905	COG1199	ATP-dependent helicase activity
H7R74_RS10915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7R74_RS10920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7R74_RS10925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7R74_RS10930	COG0131	Imidazoleglycerol-phosphate dehydratase
H7R74_RS10930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R74_RS10935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7R74_RS10940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7R74_RS10945	COG0107	imidazoleglycerol-phosphate synthase activity
H7R74_RS10960	COG2199	diguanylate cyclase activity
H7R74_RS10965	COG0318	PFAM AMP-dependent synthetase and ligase
H7R74_RS10970	COG1288	antiporter activity
H7R74_RS10980	COG3134	Outer membrane lipoprotein
H7R74_RS10985	COG2080	2 iron, 2 sulfur cluster binding
H7R74_RS10990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7R74_RS10995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7R74_RS11000	COG2252	PERMEase
H7R74_RS11005	COG0402	S-adenosylhomocysteine deaminase activity
H7R74_RS11010	COG2233	PERMEase
H7R74_RS11015	COG2080	2 iron, 2 sulfur cluster binding
H7R74_RS11015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7R74_RS11020	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7R74_RS11025	COG0402	S-adenosylhomocysteine deaminase activity
H7R74_RS11030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R74_RS11030	COG0493	'glutamate synthase
H7R74_RS11035	COG2068	MobA-Related Protein
H7R74_RS11040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7R74_RS11045	COG3608	succinylglutamate desuccinylase aspartoacylase
H7R74_RS11045	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7R74_RS11050	COG0697	spore germination
H7R74_RS11055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R74_RS11060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R74_RS11075	COG0549	Belongs to the carbamate kinase family
H7R74_RS11085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7R74_RS11090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7R74_RS11095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7R74_RS11125	COG0242	peptide deformylase activity
H7R74_RS11140	COG5433	transposase activity
H7R74_RS11155	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7R74_RS11160	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7R74_RS11165	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H7R74_RS11175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R74_RS11180	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H7R74_RS11190	COG0205	6-phosphofructokinase activity
H7R74_RS11200	COG3123	guanosine phosphorylase activity
H7R74_RS11205	COG1760	l-serine dehydratase
H7R74_RS11210	COG1760	l-serine dehydratase
H7R74_RS11215	COG3100	YcgL domain-containing protein
H7R74_RS11220	COG0850	regulation of cytokinetic process
H7R74_RS11225	COG2894	cell division
H7R74_RS11230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7R74_RS11235	COG3099	Belongs to the UPF0263 family
H7R74_RS11240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R74_RS11280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7R74_RS11285	COG0697	spore germination
H7R74_RS11290	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H7R74_RS11295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R74_RS11305	COG0307	riboflavin synthase, alpha
H7R74_RS11320	COG0534	Mate efflux family protein
H7R74_RS11335	COG3829	transcription factor binding
H7R74_RS11350	COG4681	YaeQ
H7R74_RS11365	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R74_RS11370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7R74_RS11375	COG0586	Pfam SNARE associated Golgi protein
H7R74_RS11385	COG0556	nucleotide-excision repair
H7R74_RS11405	COG0569	domain protein
H7R74_RS11405	COG2985	domain, Protein
H7R74_RS11410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7R74_RS11415	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7R74_RS11415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R74_RS11430	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R74_RS11445	COG1451	nucleotide metabolic process
H7R74_RS11460	COG0417	DNA replication proofreading
H7R74_RS11485	COG1560	Kdo2-lipid A biosynthetic process
H7R74_RS11490	COG1560	Kdo2-lipid A biosynthetic process
H7R74_RS11505	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H7R74_RS11510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7R74_RS11515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7R74_RS11520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7R74_RS11525	COG2832	Protein of unknown function (DUF454)
H7R74_RS11530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R74_RS11545	COG1011	Hydrolase
H7R74_RS11550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R74_RS11600	COG3593	DNA synthesis involved in DNA repair
H7R74_RS11615	COG0583	DNA-binding transcription factor activity
H7R74_RS11620	COG0730	response to heat
H7R74_RS11625	COG3148	PFAM DTW domain containing protein
H7R74_RS11630	COG1846	Transcriptional regulator
H7R74_RS11630	COG1940	carbohydrate kinase activity
H7R74_RS11635	COG0840	transmembrane signaling receptor activity
H7R74_RS11640	COG3012	SEC-C Motif Domain Protein
H7R74_RS11645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7R74_RS11650	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
H7R74_RS11655	COG0247	lactate metabolic process
H7R74_RS11670	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H7R74_RS11675	COG0437	4 iron, 4 sulfur cluster binding
H7R74_RS11680	COG3301	Polysulphide reductase, NrfD
H7R74_RS11685	COG1138	Cytochrome C-type biogenesis protein
H7R74_RS11695	COG3088	subunit of a heme lyase
H7R74_RS11695	COG4235	cytochrome complex assembly
H7R74_RS11710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R74_RS11720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H7R74_RS11730	COG1840	ABC-type Fe3 transport system, periplasmic component
H7R74_RS11735	COG3842	ATPase activity
H7R74_RS11745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R74_RS11785	COG1115	amino acid carrier protein
H7R74_RS11815	COG4695	Portal protein
H7R74_RS11820	COG1024	Enoyl-CoA hydratase
H7R74_RS11835	COG3162	membrane
H7R74_RS11840	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R74_RS11845	COG0488	(ABC) transporter
H7R74_RS11850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R74_RS11855	COG0776	regulation of translation
H7R74_RS11860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7R74_RS11865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7R74_RS11870	COG0740	serine-type endopeptidase activity
H7R74_RS11875	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7R74_RS11885	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H7R74_RS11890	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R74_RS11895	COG1136	(ABC) transporter
H7R74_RS11900	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R74_RS11910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7R74_RS11915	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7R74_RS11920	COG4166	transmembrane transport
H7R74_RS11925	COG0697	spore germination
H7R74_RS11930	COG3328	transposase activity
H7R74_RS11940	COG2062	phosphohistidine phosphatase, SixA
H7R74_RS11945	COG1025	Belongs to the peptidase M16 family
H7R74_RS11970	COG5290	Psort location Cytoplasmic, score
H7R74_RS11975	COG5433	transposase activity
H7R74_RS11990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R74_RS11990	COG0519	Catalyzes the synthesis of GMP from XMP
H7R74_RS11995	COG0516	GMP reductase activity
H7R74_RS11995	COG0517	IMP dehydrogenase activity
H7R74_RS12000	COG3038	cytochrome b561
H7R74_RS12005	COG1570	exodeoxyribonuclease VII activity
H7R74_RS12010	COG2188	Transcriptional regulator
H7R74_RS12015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R74_RS12015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R74_RS12015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R74_RS12020	COG0383	alpha-mannosidase activity
H7R74_RS12025	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7R74_RS12035	COG0386	Belongs to the glutathione peroxidase family
H7R74_RS12040	COG0513	Belongs to the DEAD box helicase family
H7R74_RS12055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R74_RS12060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7R74_RS12065	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7R74_RS12115	COG3300	MHYT domain
H7R74_RS12115	COG5001	Diguanylate cyclase
H7R74_RS12130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R74_RS12140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7R74_RS12145	COG0563	adenylate kinase activity
H7R74_RS12160	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7R74_RS12165	COG1286	toxin biosynthetic process
H7R74_RS12175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7R74_RS12180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7R74_RS12185	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7R74_RS12190	COG1674	ftsk spoiiie
H7R74_RS12190	COG0531	amino acid
H7R74_RS12200	COG0686	Belongs to the AlaDH PNT family
H7R74_RS12205	COG0492	ferredoxin-NADP+ reductase activity
H7R74_RS12210	COG3706	GGDEF domain
H7R74_RS12215	COG3134	Outer membrane lipoprotein
H7R74_RS12220	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7R74_RS12225	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7R74_RS12230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7R74_RS12235	COG0542	response to heat
H7R74_RS12240	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7R74_RS12245	COG1278	Cold shock
H7R74_RS12250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7R74_RS12270	COG0745	RESPONSE REGULATOR receiver
H7R74_RS12275	COG2205	protein histidine kinase activity
H7R74_RS12285	COG0392	lysyltransferase activity
H7R74_RS12285	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7R74_RS12300	COG0659	secondary active sulfate transmembrane transporter activity
H7R74_RS12335	COG0672	)-iron permease
H7R74_RS12355	COG2814	Major facilitator Superfamily
H7R74_RS12370	COG1136	(ABC) transporter
H7R74_RS12375	COG0577	efflux transmembrane transporter activity
H7R74_RS12390	COG0596	Alpha beta hydrolase
H7R74_RS12410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R74_RS12415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7R74_RS12415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R74_RS12420	COG0527	aspartate kinase activity
H7R74_RS12430	COG1368	sulfuric ester hydrolase activity
H7R74_RS12435	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7R74_RS12440	COG4667	esterase of the alpha-beta hydrolase superfamily
H7R74_RS12460	COG1648	precorrin-2 dehydrogenase activity
H7R74_RS12460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R74_RS12470	COG0393	Putative heavy-metal-binding
H7R74_RS12475	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H7R74_RS12480	COG0285	dihydrofolate synthase activity
H7R74_RS12485	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7R74_RS12490	COG0101	tRNA pseudouridine synthase activity
H7R74_RS12500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R74_RS12510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R74_RS12515	COG0671	phosphoesterase, PA-phosphatase related
H7R74_RS12520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R74_RS12525	COG2056	Na+-H+ antiporter family
H7R74_RS12530	COG5001	Diguanylate cyclase
H7R74_RS12530	COG3300	MHYT domain
H7R74_RS12545	COG2050	protein possibly involved in aromatic compounds catabolism
H7R74_RS12555	COG0247	lactate metabolic process
H7R74_RS12555	COG0277	FAD linked oxidase domain protein
H7R74_RS12565	COG1253	flavin adenine dinucleotide binding
H7R74_RS12570	COG1902	pentaerythritol trinitrate reductase activity
H7R74_RS12575	COG1028	Short-chain dehydrogenase reductase Sdr
H7R74_RS12575	COG3321	synthase
H7R74_RS12575	COG0604	alcohol dehydrogenase
H7R74_RS12585	COG0647	UMP catabolic process
H7R74_RS12590	COG4651	solute:proton antiporter activity
H7R74_RS12590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7R74_RS12600	COG0367	asparagine synthase
H7R74_RS12630	COG0322	excinuclease ABC activity
H7R74_RS12635	COG2197	response regulator
H7R74_RS12640	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7R74_RS12645	COG2835	tetraacyldisaccharide 4'-kinase activity
H7R74_RS12650	COG1663	tetraacyldisaccharide 4'-kinase activity
H7R74_RS12660	COG2333	competence protein COMEC
H7R74_RS12660	COG0658	competence protein
H7R74_RS12675	COG1448	Aminotransferase
H7R74_RS12685	COG0583	DNA-binding transcription factor activity
H7R74_RS12690	COG3085	chromosome segregation
H7R74_RS12695	COG4574	serine-type endopeptidase inhibitor activity
H7R74_RS12700	COG0584	glycerophosphoryl diester phosphodiesterase
H7R74_RS12710	COG1349	DNA-binding transcription factor activity
H7R74_RS12730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R74_RS12735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7R74_RS12740	COG0840	transmembrane signaling receptor activity
H7R74_RS12750	COG0583	DNA-binding transcription factor activity
H7R74_RS12765	COG0656	L-ascorbic acid biosynthetic process
H7R74_RS12775	COG2814	Major facilitator Superfamily
H7R74_RS12780	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R74_RS12795	COG3220	belongs to the UPF0276 family
H7R74_RS12815	COG1294	oxidase, subunit
H7R74_RS12825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R74_RS12835	COG2979	Protein of unknown function (DUF533)
H7R74_RS12850	COG0583	DNA-binding transcription factor activity
H7R74_RS12855	COG2807	transmembrane transport
H7R74_RS12860	COG1187	pseudouridine synthase activity
H7R74_RS12870	COG0346	lactoylglutathione lyase activity
H7R74_RS12880	COG1061	Type III restriction enzyme res subunit
H7R74_RS12885	COG4657	Part of a membrane complex involved in electron transport
H7R74_RS12890	COG2878	Part of a membrane complex involved in electron transport
H7R74_RS12900	COG4658	electron transport chain
H7R74_RS12905	COG4659	FMN binding
H7R74_RS12910	COG4660	Part of a membrane complex involved in electron transport
H7R74_RS12915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7R74_RS12920	COG0346	lactoylglutathione lyase activity
H7R74_RS12945	COG2801	Transposase and inactivated derivatives
H7R74_RS12955	COG5433	transposase activity
H7R74_RS12965	COG1199	ATP-dependent helicase activity
H7R74_RS12975	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7R74_RS12980	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7R74_RS12985	COG1785	Belongs to the alkaline phosphatase family
H7R74_RS13005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R74_RS13010	COG2197	response regulator
H7R74_RS13020	COG2271	Major facilitator Superfamily
H7R74_RS13025	COG3706	GGDEF domain
H7R74_RS13030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R74_RS13035	COG0765	amino acid transport
H7R74_RS13040	COG1126	abc transporter atp-binding protein
H7R74_RS13070	COG1253	flavin adenine dinucleotide binding
H7R74_RS13075	COG0704	Plays a role in the regulation of phosphate uptake
H7R74_RS13080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7R74_RS13085	COG0581	inorganic phosphate transmembrane transporter activity
H7R74_RS13090	COG0573	inorganic phosphate transmembrane transporter activity
H7R74_RS13095	COG0590	tRNA wobble adenosine to inosine editing
H7R74_RS13110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7R74_RS13130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7R74_RS13135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7R74_RS13140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7R74_RS13145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7R74_RS13170	COG2716	regulation of RNA biosynthetic process
H7R74_RS13175	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7R74_RS13185	COG2239	Acts as a magnesium transporter
H7R74_RS13190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7R74_RS13205	COG1706	bacterial-type flagellum-dependent cell motility
H7R74_RS13210	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7R74_RS13220	COG4787	bacterial-type flagellum-dependent cell motility
H7R74_RS13240	COG1815	bacterial-type flagellum-dependent cell motility
H7R74_RS13245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7R74_RS13250	COG0784	Response regulator, receiver
H7R74_RS13250	COG0835	chemotaxis
H7R74_RS13255	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H7R74_RS13270	COG0622	Phosphoesterase
H7R74_RS13275	COG4166	transmembrane transport
H7R74_RS13285	COG1187	pseudouridine synthase activity
H7R74_RS13290	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R74_RS13300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R74_RS13305	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R74_RS13310	COG1882	Formate acetyltransferase
H7R74_RS13315	COG1349	DNA-binding transcription factor activity
H7R74_RS13320	COG4166	transmembrane transport
H7R74_RS13345	COG1278	Cold shock
H7R74_RS13370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H7R74_RS13370	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H7R74_RS13375	COG1028	Short-chain dehydrogenase reductase Sdr
H7R74_RS13380	COG3433	isochorismatase activity
H7R74_RS13380	COG1535	isochorismatase
H7R74_RS13385	COG1021	2,3-dihydroxybenzoate-AMP ligase
H7R74_RS13390	COG1169	isochorismate synthase
H7R74_RS13395	COG4771	TonB-dependent receptor
H7R74_RS13400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R74_RS13405	COG1609	Transcriptional regulator
H7R74_RS13410	COG0741	lytic transglycosylase activity
H7R74_RS13420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7R74_RS13440	COG2911	Protein conserved in bacteria
H7R74_RS13445	COG0729	surface antigen
H7R74_RS13455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R74_RS13465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7R74_RS13475	COG4134	Bacterial extracellular solute-binding protein
H7R74_RS13485	COG4136	ATPase activity
H7R74_RS13490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7R74_RS13495	COG2951	lytic endotransglycosylase activity
H7R74_RS13500	COG1846	Transcriptional regulator
H7R74_RS13510	COG0033	Phosphoglucomutase
H7R74_RS13515	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H7R74_RS13520	COG0596	Alpha beta hydrolase
H7R74_RS13535	COG0716	FMN binding
H7R74_RS13545	COG0735	belongs to the Fur family
H7R74_RS13550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R74_RS13560	COG1263	PTS System
H7R74_RS13560	COG2190	(PTS) system
H7R74_RS13560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R74_RS13565	COG0363	glucosamine-6-phosphate deaminase activity
H7R74_RS13570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R74_RS13575	COG1846	Transcriptional regulator
H7R74_RS13575	COG1940	carbohydrate kinase activity
H7R74_RS13580	COG2194	sulfuric ester hydrolase activity
H7R74_RS13585	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R74_RS13585	COG2199	diguanylate cyclase activity
H7R74_RS13590	COG3275	phosphorelay sensor kinase activity
H7R74_RS13595	COG3279	Response regulator of the LytR AlgR family
H7R74_RS13600	COG1966	Carbon starvation protein
H7R74_RS13610	COG1566	PFAM secretion protein HlyD family protein
H7R74_RS13615	COG1061	Type III restriction enzyme res subunit
H7R74_RS13620	COG2027	D-alanyl-D-alanine carboxypeptidase
H7R74_RS13625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7R74_RS13630	COG3021	interspecies interaction between organisms
H7R74_RS13640	COG1607	acyl-coa hydrolase
H7R74_RS13645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R74_RS13655	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7R74_RS13655	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7R74_RS13655	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7R74_RS13655	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7R74_RS13670	COG0633	Ferredoxin
H7R74_RS13670	COG3217	Mosc domain protein beta barrel domain protein
H7R74_RS13670	COG0633	Ferredoxin
H7R74_RS13670	COG3217	Mosc domain protein beta barrel domain protein
H7R74_RS13680	COG0501	Belongs to the peptidase M48B family
H7R74_RS13685	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7R74_RS13690	COG1073	alpha beta
H7R74_RS13690	COG2226	methyltransferase
H7R74_RS13695	COG0156	8-amino-7-oxononanoate synthase activity
H7R74_RS13700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R74_RS13705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7R74_RS13720	COG0017	Asparaginyl-tRNA synthetase
H7R74_RS13730	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R74_RS13740	COG1473	amidohydrolase
H7R74_RS13745	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R74_RS13760	COG1393	Belongs to the ArsC family
H7R74_RS13765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7R74_RS13770	COG1876	peptidase activity
H7R74_RS13780	COG3263	regulation of cellular component size
H7R74_RS13795	COG1280	lysine exporter protein (LysE YggA)
H7R74_RS13825	COG0564	pseudouridine synthase activity
H7R74_RS13835	COG1454	alcohol dehydrogenase
H7R74_RS13875	COG2894	cell division
H7R74_RS13885	COG4964	Belongs to the GSP D family
H7R74_RS13915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R74_RS13920	COG0702	epimerase
H7R74_RS13930	COG0095	Lipoate-protein ligase
H7R74_RS13940	COG1136	(ABC) transporter
H7R74_RS13940	COG0577	efflux transmembrane transporter activity
H7R74_RS13945	COG0577	efflux transmembrane transporter activity
H7R74_RS13945	COG1136	(ABC) transporter
H7R74_RS13950	COG1136	(ABC) transporter
H7R74_RS13950	COG0577	efflux transmembrane transporter activity
H7R74_RS13955	COG1566	PFAM secretion protein HlyD family protein
H7R74_RS13995	COG1285	pathogenesis
H7R74_RS14025	COG0484	heat shock protein binding
H7R74_RS14030	COG0443	Heat shock 70 kDa protein
H7R74_RS14035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7R74_RS14040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7R74_RS14045	COG0497	DNA recombination
H7R74_RS14050	COG1227	inorganic diphosphatase activity
H7R74_RS14055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R74_RS14060	COG1136	(ABC) transporter
H7R74_RS14060	COG0577	efflux transmembrane transporter activity
H7R74_RS14080	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H7R74_RS14090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7R74_RS14095	COG1091	dTDP-4-dehydrorhamnose reductase activity
H7R74_RS14100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7R74_RS14105	COG0438	transferase activity, transferring glycosyl groups
H7R74_RS14115	COG0438	transferase activity, transferring glycosyl groups
H7R74_RS14125	COG0438	transferase activity, transferring glycosyl groups
H7R74_RS14135	COG1216	Glycosyl transferase, family 2
H7R74_RS14160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7R74_RS14170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R74_RS14175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R74_RS14180	COG1309	transcriptional regulator
H7R74_RS14195	COG1342	Belongs to the UPF0251 family
H7R74_RS14215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R74_RS14240	COG0813	purine-nucleoside phosphorylase activity
H7R74_RS14255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7R74_RS14260	COG0083	homoserine kinase activity
H7R74_RS14270	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7R74_RS14275	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H7R74_RS14280	COG1946	Acyl-CoA thioesterase
H7R74_RS14295	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7R74_RS14305	COG0009	L-threonylcarbamoyladenylate synthase
H7R74_RS14315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7R74_RS14320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R74_RS14320	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R74_RS14325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R74_RS14330	COG0134	indole-3-glycerol-phosphate synthase activity
H7R74_RS14330	COG0135	phosphoribosylanthranilate isomerase activity
H7R74_RS14335	COG0133	tryptophan synthase activity
H7R74_RS14340	COG0159	tryptophan synthase activity
H7R74_RS14355	COG1988	membrane-bound metal-dependent
H7R74_RS14375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R74_RS14385	COG0798	PFAM Bile acid sodium symporter
H7R74_RS14415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R74_RS14425	COG0745	RESPONSE REGULATOR receiver
H7R74_RS14440	COG4988	ABC transporter
H7R74_RS14445	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7R74_RS14465	COG1720	tRNA m6t6A37 methyltransferase activity
H7R74_RS14470	COG3038	cytochrome b561
H7R74_RS14490	COG2862	Uncharacterized protein family, UPF0114
H7R74_RS14505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R74_RS14510	COG1917	Cupin 2, conserved barrel domain protein
H7R74_RS14510	COG1396	sequence-specific DNA binding
H7R74_RS14525	COG0531	amino acid
H7R74_RS14535	COG0531	amino acid
H7R74_RS14540	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7R74_RS14555	COG2974	May be involved in recombination
H7R74_RS14565	COG0420	3'-5' exonuclease activity
H7R74_RS14570	COG0419	ATPase involved in DNA repair
H7R74_RS14575	COG3384	dioxygenase
H7R74_RS14585	COG0469	pyruvate kinase activity
H7R74_RS14590	COG3264	Mechanosensitive ion channel
H7R74_RS14590	COG1196	nuclear chromosome segregation
H7R74_RS14600	COG3590	peptidase
H7R74_RS14610	COG2190	(PTS) system
H7R74_RS14620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R74_RS14625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7R74_RS14630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7R74_RS14645	COG2770	Histidine kinase
H7R74_RS14645	COG3437	response regulator, receiver
H7R74_RS14650	COG3267	Type II secretory pathway component ExeA
H7R74_RS14650	COG3409	Peptidoglycan-binding domain 1 protein
H7R74_RS14670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R74_RS14675	COG1459	type II secretion system
H7R74_RS14680	COG2165	general secretion pathway protein
H7R74_RS14690	COG2165	general secretion pathway protein
H7R74_RS14695	COG4795	General secretion pathway protein
H7R74_RS14700	COG3156	type II secretion system protein K
H7R74_RS14710	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H7R74_RS14720	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H7R74_RS14745	COG0561	phosphatase activity
H7R74_RS14750	COG3623	hexulose-6-phosphate isomerase
H7R74_RS14765	COG0670	Belongs to the BI1 family
H7R74_RS14770	COG1289	transmembrane transporter activity
H7R74_RS14775	COG2920	part of a sulfur-relay system
H7R74_RS14780	COG0673	inositol 2-dehydrogenase activity
H7R74_RS14820	COG1032	radical SAM domain protein
H7R74_RS14830	COG1566	PFAM secretion protein HlyD family protein
H7R74_RS14835	COG3706	GGDEF domain
H7R74_RS14840	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R74_RS14845	COG0531	amino acid
H7R74_RS14875	COG0281	malic enzyme
H7R74_RS14885	COG0534	Mate efflux family protein
H7R74_RS14900	COG2233	PERMEase
H7R74_RS14905	COG0095	Lipoate-protein ligase
H7R74_RS14910	COG1115	amino acid carrier protein
H7R74_RS14915	COG0019	diaminopimelate decarboxylase activity
H7R74_RS14925	COG0678	peroxiredoxin activity
H7R74_RS14950	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R74_RS14955	COG3142	Participates in the control of copper homeostasis
H7R74_RS14980	COG5002	protein histidine kinase activity
H7R74_RS14985	COG0745	RESPONSE REGULATOR receiver
H7R74_RS14990	COG0346	lactoylglutathione lyase activity
H7R74_RS14995	COG3284	Transcriptional regulator
H7R74_RS15010	COG0697	spore germination
H7R74_RS15020	COG3290	protein histidine kinase activity
H7R74_RS15025	COG0281	malic enzyme
H7R74_RS15035	COG1846	Transcriptional regulator
H7R74_RS15040	COG1566	PFAM secretion protein HlyD family protein
H7R74_RS15070	COG0602	queuosine metabolic process
H7R74_RS15075	COG1328	CTP reductase activity
H7R74_RS15085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7R74_RS15090	COG3115	cell septum assembly
H7R74_RS15095	COG1196	nuclear chromosome segregation
H7R74_RS15105	COG2860	membrane
H7R74_RS15115	COG3108	Peptidase M15
H7R74_RS15120	COG2989	Protein conserved in bacteria
H7R74_RS15135	COG0463	Glycosyl transferase, family 2
H7R74_RS15150	COG0366	Alpha amylase catalytic
H7R74_RS15185	COG2203	Gaf domain
H7R74_RS15185	COG2199	diguanylate cyclase activity
H7R74_RS15195	COG3590	peptidase
H7R74_RS15205	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7R74_RS15210	COG1982	Orn Lys Arg decarboxylase major
H7R74_RS15215	COG0531	amino acid
H7R74_RS15225	COG3710	Transcriptional regulator
H7R74_RS15230	COG0531	amino acid
H7R74_RS15250	COG0814	amino acid
H7R74_RS15280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R74_RS15285	COG0739	heme binding
H7R74_RS15290	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7R74_RS15300	COG0251	oxidation-reduction process
H7R74_RS15315	COG0583	DNA-binding transcription factor activity
H7R74_RS15320	COG0604	alcohol dehydrogenase
H7R74_RS15320	COG3321	synthase
H7R74_RS15320	COG1028	Short-chain dehydrogenase reductase Sdr
H7R74_RS15330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7R74_RS15340	COG3091	SprT-like family
H7R74_RS15350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7R74_RS15355	COG0189	ligase activity
H7R74_RS15360	COG1678	Uncharacterized ACR, COG1678
H7R74_RS15365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7R74_RS15370	COG3104	oligopeptide transport
H7R74_RS15385	COG0714	Associated with various cellular activities
H7R74_RS15400	COG1115	amino acid carrier protein
H7R74_RS15405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R74_RS15415	COG0825	malonyl-CoA metabolic process
H7R74_RS15425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7R74_RS15430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R74_RS15435	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R74_RS15440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R74_RS15445	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R74_RS15455	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R74_RS15460	COG0750	zinc metalloprotease
H7R74_RS15465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7R74_RS15470	COG0575	Belongs to the CDS family
H7R74_RS15475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7R74_RS15480	COG0233	cytoplasmic translational termination
H7R74_RS15485	COG0528	UMP kinase activity
H7R74_RS15490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7R74_RS15495	COG0052	Belongs to the universal ribosomal protein uS2 family
H7R74_RS15500	COG0024	Methionine aminopeptidase
H7R74_RS15510	COG2171	N-acyltransferase activity
H7R74_RS15520	COG1263	PTS System
H7R74_RS15520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R74_RS15540	COG0564	pseudouridine synthase activity
H7R74_RS15545	COG3098	single-species biofilm formation
H7R74_RS15570	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H7R74_RS15580	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R74_RS15580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R74_RS15595	COG1611	Belongs to the LOG family
H7R74_RS15600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R74_RS15605	COG0473	3-isopropylmalate dehydrogenase activity
H7R74_RS15615	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H7R74_RS15620	COG2363	Small membrane protein
H7R74_RS15630	COG0583	DNA-binding transcription factor activity
H7R74_RS15635	COG0840	transmembrane signaling receptor activity
H7R74_RS15640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7R74_RS15655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7R74_RS15660	COG1666	GTP binding
H7R74_RS15670	COG2211	Major facilitator Superfamily
H7R74_RS15675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R74_RS15685	COG2813	Specifically methylates the guanine in position
H7R74_RS15690	COG0271	Belongs to the BolA IbaG family
H7R74_RS15695	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R74_RS15700	COG1805	sodium ion transport
H7R74_RS15705	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R74_RS15710	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R74_RS15715	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R74_RS15720	COG2871	sodium ion transport
H7R74_RS15725	COG1477	protein flavinylation
H7R74_RS15755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7R74_RS15770	COG0300	oxidoreductase activity
H7R74_RS15780	COG0415	Belongs to the DNA photolyase family
H7R74_RS15785	COG0789	Transcriptional regulator
H7R74_RS15790	COG3272	Protein of unknown function (DUF1722)
H7R74_RS15820	COG0077	Prephenate dehydratase
H7R74_RS15820	COG1605	Chorismate mutase
H7R74_RS15920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R74_RS15965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R74_RS16015	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R74_RS16025	COG3039	Transposase
H7R74_RS16035	COG5433	transposase activity
H7R74_RS16065	COG5377	YqaJ viral recombinase family
H7R74_RS16095	COG2003	Belongs to the UPF0758 family
H7R74_RS16110	COG4735	regulation of single-species biofilm formation
H7R74_RS16120	COG3328	transposase activity
H7R74_RS16135	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7R74_RS16170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R74_RS16195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7R74_RS16230	COG0840	transmembrane signaling receptor activity
H7R74_RS16240	COG0300	oxidoreductase activity
H7R74_RS16265	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H7R74_RS16305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7R74_RS16310	COG0826	peptidase U32
H7R74_RS16315	COG1280	lysine exporter protein (LysE YggA)
H7R74_RS16325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R74_RS16335	COG0745	RESPONSE REGULATOR receiver
H7R74_RS16345	COG2198	Histidine kinase
H7R74_RS16345	COG0643	Histidine kinase
H7R74_RS16355	COG0835	chemotaxis
H7R74_RS16360	COG0840	transmembrane signaling receptor activity
H7R74_RS16370	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H7R74_RS16375	COG2201	protein-glutamate methylesterase activity
H7R74_RS16380	COG1185	polyribonucleotide nucleotidyltransferase activity
H7R74_RS16385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7R74_RS16390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7R74_RS16395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7R74_RS16400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7R74_RS16405	COG0195	Participates in both transcription termination and antitermination
H7R74_RS16410	COG0779	Required for maturation of 30S ribosomal subunits
H7R74_RS16425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7R74_RS16430	COG0149	triose-phosphate isomerase activity
H7R74_RS16435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7R74_RS16440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7R74_RS16450	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7R74_RS16455	COG1534	Rna-binding protein
H7R74_RS16470	COG1360	Flagellar Motor Protein
H7R74_RS16475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R74_RS16480	COG1722	exodeoxyribonuclease VII activity
H7R74_RS16485	COG0142	geranyltranstransferase activity
H7R74_RS16490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7R74_RS16495	COG0737	Belongs to the 5'-nucleotidase family
H7R74_RS16515	COG2204	response regulator
H7R74_RS16520	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R74_RS16530	COG2900	Belongs to the SlyX family
H7R74_RS16540	COG0601	transmembrane transport
H7R74_RS16555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7R74_RS16560	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7R74_RS16565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R74_RS16570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7R74_RS16585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R74_RS16585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R74_RS16590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7R74_RS16595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7R74_RS16605	COG0784	Response regulator, receiver
H7R74_RS16605	COG2198	Histidine kinase
H7R74_RS16605	COG2205	protein histidine kinase activity
H7R74_RS16610	COG1879	ABC-type sugar transport system periplasmic component
H7R74_RS16620	COG0745	RESPONSE REGULATOR receiver
H7R74_RS16625	COG3005	denitrification pathway
H7R74_RS16635	COG3381	protein complex oligomerization
H7R74_RS16655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R74_RS16660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7R74_RS16665	COG0511	ligase activity, forming carbon-carbon bonds
H7R74_RS16670	COG0439	Biotin carboxylase
H7R74_RS16675	COG3924	membrane
H7R74_RS16680	COG4145	pantothenate transmembrane transporter activity
H7R74_RS16685	COG1263	PTS System
H7R74_RS16685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R74_RS16685	COG2190	(PTS) system
H7R74_RS16690	COG0583	DNA-binding transcription factor activity
H7R74_RS16695	COG0604	alcohol dehydrogenase
H7R74_RS16700	COG2264	protein methyltransferase activity
H7R74_RS16710	COG0778	Nitroreductase
H7R74_RS16715	COG1902	pentaerythritol trinitrate reductase activity
H7R74_RS16715	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R74_RS16720	COG0616	signal peptide processing
H7R74_RS16740	COG0848	biopolymer transport protein
H7R74_RS16745	COG0811	peptide transport
H7R74_RS16750	COG0811	peptide transport
H7R74_RS16765	COG4174	ABC transporter (Permease)
H7R74_RS16770	COG4239	(ABC) transporter, permease
H7R74_RS16780	COG0444	Belongs to the ABC transporter superfamily
H7R74_RS16785	COG4608	Belongs to the ABC transporter superfamily
H7R74_RS16805	COG3416	Protein conserved in bacteria
H7R74_RS16815	COG0741	lytic transglycosylase activity
H7R74_RS16830	COG0488	(ABC) transporter
H7R74_RS16840	COG2252	PERMEase
H7R74_RS16845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R74_RS16850	COG0840	transmembrane signaling receptor activity
H7R74_RS16860	COG1278	Cold shock
H7R74_RS16900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7R74_RS16910	COG0688	phosphatidylethanolamine metabolic process
H7R74_RS16915	COG4628	conserved protein (DUF2132)
H7R74_RS16930	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7R74_RS16945	COG1073	alpha beta
H7R74_RS16950	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H7R74_RS16955	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R74_RS16960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R74_RS16965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7R74_RS16970	COG3178	'Phosphotransferase
H7R74_RS16975	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7R74_RS16980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R74_RS16985	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7R74_RS16990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7R74_RS16995	COG2967	ApaG domain
H7R74_RS17000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7R74_RS17015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7R74_RS17025	COG3314	Sporulation integral membrane protein YlbJ
H7R74_RS17030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7R74_RS17035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7R74_RS17040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7R74_RS17045	COG0142	geranyltranstransferase activity
H7R74_RS17050	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H7R74_RS17055	COG0330	HflC and HflK could
H7R74_RS17060	COG0330	HflC and HflK could
H7R74_RS17065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7R74_RS17070	COG1923	regulation of RNA biosynthetic process
H7R74_RS17075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7R74_RS17080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7R74_RS17085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7R74_RS17095	COG0802	atpase or kinase
H7R74_RS17100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7R74_RS17100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7R74_RS17120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7R74_RS17125	COG2011	ABC-type metal ion transport system permease component
H7R74_RS17130	COG1464	Belongs to the NlpA lipoprotein family
H7R74_RS17165	COG2198	Histidine kinase
H7R74_RS17165	COG5002	protein histidine kinase activity
H7R74_RS17165	COG0784	Response regulator, receiver
H7R74_RS17200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7R74_RS17205	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H7R74_RS17210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R74_RS17215	COG2716	regulation of RNA biosynthetic process
H7R74_RS17220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7R74_RS17225	COG3013	Belongs to the UPF0304 family
H7R74_RS17235	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R74_RS17240	COG0280	phosphate acetyltransferase
H7R74_RS17240	COG0857	belongs to the CobB CobQ family
H7R74_RS17245	COG1555	photosystem II stabilization
H7R74_RS17250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7R74_RS17255	COG3104	oligopeptide transport
H7R74_RS17260	COG0745	RESPONSE REGULATOR receiver
H7R74_RS17290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R74_RS17305	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7R74_RS17340	COG0440	acetolactate synthase activity
H7R74_RS17345	COG0028	Belongs to the TPP enzyme family
H7R74_RS17370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7R74_RS17375	COG0473	3-isopropylmalate dehydrogenase activity
H7R74_RS17380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7R74_RS17385	COG0066	3-isopropylmalate dehydratase activity
H7R74_RS17400	COG4143	(ABC) transporter
H7R74_RS17405	COG1178	ABC-type Fe3 transport system permease component
H7R74_RS17410	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H7R74_RS17415	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7R74_RS17425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R74_RS17465	COG0459	protein refolding
H7R74_RS17470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7R74_RS17475	COG0534	Mate efflux family protein
H7R74_RS17480	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7R74_RS17485	COG1027	Aspartate ammonia-lyase
H7R74_RS17490	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R74_RS17495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7R74_RS17500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7R74_RS17505	COG1610	YqeY-like protein
H7R74_RS17515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7R74_RS17535	COG0151	Belongs to the GarS family
H7R74_RS17540	COG0138	bifunctional purine biosynthesis protein purh
H7R74_RS17550	COG3036	rescue of stalled ribosome
H7R74_RS17555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7R74_RS17560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7R74_RS17570	COG0673	inositol 2-dehydrogenase activity
H7R74_RS17580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R74_RS17585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R74_RS17595	COG0583	DNA-binding transcription factor activity
H7R74_RS17600	COG0477	Major facilitator Superfamily
H7R74_RS17615	COG1028	Short-chain dehydrogenase reductase Sdr
H7R74_RS17625	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H7R74_RS17640	COG0456	acetyltransferase
H7R74_RS17650	COG1022	Amp-dependent synthetase and ligase
H7R74_RS17655	COG2918	glutathione biosynthetic process
H7R74_RS17660	COG0612	Peptidase, M16
H7R74_RS17665	COG1238	metal cluster binding
H7R74_RS17670	COG3321	synthase
H7R74_RS17670	COG0604	alcohol dehydrogenase
H7R74_RS17695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R74_RS17700	COG0359	binds to the 23S rRNA
H7R74_RS17705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7R74_RS17710	COG0360	Binds together with S18 to 16S ribosomal RNA
H7R74_RS17715	COG1914	H( )-stimulated, divalent metal cation uptake system
H7R74_RS17720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7R74_RS17730	COG0776	regulation of translation
H7R74_RS17745	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H7R74_RS17760	COG0560	Phosphoserine phosphatase
H7R74_RS17770	COG0813	purine-nucleoside phosphorylase activity
H7R74_RS17775	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H7R74_RS17780	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7R74_RS17785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7R74_RS17795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R74_RS17800	COG0084	hydrolase, TatD family'
H7R74_RS17805	COG2165	general secretion pathway protein
H7R74_RS17815	COG1854	S-ribosylhomocysteine lyase activity
H7R74_RS17830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R74_RS17830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7R74_RS17875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7R74_RS17880	COG1047	Peptidyl-prolyl cis-trans
H7R74_RS17885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7R74_RS17890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7R74_RS17895	COG0196	riboflavin kinase activity
H7R74_RS17900	COG0728	peptidoglycan biosynthetic process
H7R74_RS17905	COG0268	Binds directly to 16S ribosomal RNA
H7R74_RS17910	COG0640	Transcriptional regulator
H7R74_RS17915	COG0583	DNA-binding transcription factor activity
H7R74_RS17925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R74_RS17930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7R74_RS17935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7R74_RS17940	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
H7R74_RS17945	COG1051	belongs to the nudix hydrolase family
H7R74_RS17950	COG3066	DNA modification
H7R74_RS17960	COG0335	large ribosomal subunit rRNA binding
H7R74_RS17965	COG0336	Belongs to the RNA methyltransferase TrmD family
H7R74_RS17970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7R74_RS17975	COG0228	four-way junction DNA binding
H7R74_RS17980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7R74_RS17985	COG4137	Cytochrome C assembly protein
H7R74_RS17990	COG4536	flavin adenine dinucleotide binding
H7R74_RS18000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R74_RS18000	COG1017	nitric oxide dioxygenase activity
H7R74_RS18005	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H7R74_RS18010	COG0039	L-malate dehydrogenase activity
H7R74_RS18015	COG4160	amino acid transport
H7R74_RS18020	COG4215	(ABC) transporter
H7R74_RS18025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R74_RS18030	COG1126	abc transporter atp-binding protein
H7R74_RS18035	COG1438	arginine binding
H7R74_RS18040	COG2837	iron assimilation
H7R74_RS18045	COG3842	ATPase activity
H7R74_RS18055	COG1840	ABC-type Fe3 transport system, periplasmic component
H7R74_RS18060	COG0347	Belongs to the P(II) protein family
H7R74_RS18080	COG3022	response to hydroperoxide
H7R74_RS18095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7R74_RS18100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7R74_RS18105	COG0762	integral membrane protein
H7R74_RS18110	COG1872	DUF167
H7R74_RS18120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R74_RS18125	COG0583	DNA-binding transcription factor activity
H7R74_RS18140	COG1929	Belongs to the glycerate kinase type-1 family
H7R74_RS18145	COG2610	gluconate transmembrane transporter activity
H7R74_RS18150	COG3835	regulator
H7R74_RS18155	COG3112	Uncharacterised protein family (UPF0231)
H7R74_RS18185	COG0513	Belongs to the DEAD box helicase family
H7R74_RS18225	COG1448	Aminotransferase
H7R74_RS18240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R74_RS18245	COG1328	CTP reductase activity
H7R74_RS18270	COG0633	Ferredoxin
H7R74_RS18270	COG0543	2 iron, 2 sulfur cluster binding
H7R74_RS18285	COG0840	transmembrane signaling receptor activity
H7R74_RS18290	COG3397	chitin binding
H7R74_RS18295	COG0583	DNA-binding transcription factor activity
H7R74_RS18300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7R74_RS18305	COG4208	sulfate ABC transporter
H7R74_RS18310	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7R74_RS18320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7R74_RS18325	COG3174	membrane
H7R74_RS18330	COG0110	maltose O-acetyltransferase activity
H7R74_RS18345	COG1011	Hydrolase
H7R74_RS18350	COG0494	nUDIX hydrolase
H7R74_RS18355	COG1218	3'(2'),5'-bisphosphate nucleotidase
H7R74_RS18360	COG0814	amino acid
H7R74_RS18365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R74_RS18380	COG0626	cystathionine gamma-synthase activity
H7R74_RS18385	COG0460	homoserine dehydrogenase
H7R74_RS18385	COG0527	aspartate kinase activity
H7R74_RS18390	COG0306	phosphate transporter
H7R74_RS18395	COG1392	Phosphate transport regulator
H7R74_RS18405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R74_RS18410	COG2813	Specifically methylates the guanine in position
H7R74_RS18415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7R74_RS18420	COG0297	glycogen (starch) synthase activity
H7R74_RS18460	COG1757	Na H antiporter
H7R74_RS18465	COG0316	Belongs to the HesB IscA family
H7R74_RS18475	COG0038	chloride channel
H7R74_RS18480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7R74_RS18495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R74_RS18495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R74_RS18525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R74_RS18530	COG0564	pseudouridine synthase activity
H7R74_RS18540	COG0110	maltose O-acetyltransferase activity
H7R74_RS18545	COG0366	Alpha amylase catalytic
H7R74_RS18550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R74_RS18550	COG1263	PTS System
H7R74_RS18570	COG0252	asparaginase activity
H7R74_RS18575	COG1253	flavin adenine dinucleotide binding
H7R74_RS18580	COG0586	Pfam SNARE associated Golgi protein
H7R74_RS18585	COG1686	Belongs to the peptidase S11 family
H7R74_RS18620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7R74_RS18625	COG0527	aspartate kinase activity
H7R74_RS18630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7R74_RS18640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7R74_RS18645	COG1546	Belongs to the CinA family
H7R74_RS18650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7R74_RS18655	COG4667	esterase of the alpha-beta hydrolase superfamily
H7R74_RS18665	COG1346	cytolysis
H7R74_RS18670	COG1380	Effector of murein hydrolase LrgA
H7R74_RS18675	COG0583	DNA-binding transcription factor activity
H7R74_RS18685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7R74_RS18705	COG3039	Transposase
H7R74_RS18715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R74_RS18720	COG2022	thiamine diphosphate biosynthetic process
H7R74_RS18730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R74_RS18735	COG0352	thiamine-phosphate diphosphorylase activity
H7R74_RS18740	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7R74_RS18760	COG0745	RESPONSE REGULATOR receiver
H7R74_RS18765	COG0642	Histidine kinase
H7R74_RS18770	COG0189	ligase activity
H7R74_RS18815	COG0477	Major facilitator Superfamily
H7R74_RS18835	COG0312	modulator of DNA gyrase
H7R74_RS18840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R74_RS18850	COG3164	Protein of unknown function
H7R74_RS18855	COG1530	ribonuclease E activity
H7R74_RS18860	COG0424	maF-like protein
H7R74_RS18865	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7R74_RS18870	COG1792	Involved in formation and maintenance of cell shape
H7R74_RS18875	COG1077	Cell shape determining protein MreB Mrl
H7R74_RS18900	COG4968	Prepilin-type N-terminal cleavage methylation domain
H7R74_RS18905	COG4969	Belongs to the N-Me-Phe pilin family
H7R74_RS18920	COG1459	type II secretion system
H7R74_RS18925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R74_RS18970	COG2199	diguanylate cyclase activity
H7R74_RS18970	COG2200	EAL domain
H7R74_RS18990	COG0387	Pfam Sodium calcium exchanger
H7R74_RS18995	COG2986	histidine ammonia-lyase
H7R74_RS19000	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7R74_RS19005	COG0010	Belongs to the arginase family
H7R74_RS19010	COG1228	amidohydrolase
H7R74_RS19015	COG2188	Transcriptional regulator
H7R74_RS19020	COG0288	reversible hydration of carbon dioxide
H7R74_RS19030	COG2177	Part of the ABC transporter FtsEX involved in
H7R74_RS19035	COG2884	Cell division ATP-binding protein ftsE
H7R74_RS19040	COG0552	protein localization to endoplasmic reticulum
H7R74_RS19045	COG0742	ribosomal rna small subunit methyltransferase
H7R74_RS19070	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R74_RS19075	COG0583	DNA-binding transcription factor activity
H7R74_RS19080	COG4221	oxidoreductase activity
H7R74_RS19095	COG1770	oligopeptidase
H7R74_RS19110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R74_RS19120	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R74_RS19130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R74_RS19140	COG2095	MarC family integral membrane protein
H7R74_RS19150	COG1301	dicarboxylic acid transport
H7R74_RS19175	COG3714	YhhN family
H7R74_RS19225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R74_RS19230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R74_RS19235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7R74_RS19240	COG0049	tRNA binding
H7R74_RS19245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7R74_RS19250	COG2168	tRNA wobble position uridine thiolation
H7R74_RS19255	COG2923	Belongs to the DsrF TusC family
H7R74_RS19260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R74_RS19270	COG2964	Protein conserved in bacteria
H7R74_RS19275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7R74_RS19280	COG0085	RNA polymerase activity
H7R74_RS19285	COG0222	ribosome binding
H7R74_RS19290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7R74_RS19295	COG0081	regulation of translation
H7R74_RS19300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7R74_RS19305	COG0250	Participates in transcription elongation, termination and antitermination
H7R74_RS19320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R74_RS19345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7R74_RS19350	COG0569	domain protein
H7R74_RS19355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R74_RS19385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R74_RS19385	COG4191	Histidine kinase
H7R74_RS19390	COG3005	denitrification pathway
H7R74_RS19395	COG0243	molybdopterin cofactor binding
H7R74_RS19440	COG2204	response regulator
H7R74_RS19450	COG2205	protein histidine kinase activity
H7R74_RS19465	COG1028	Short-chain dehydrogenase reductase Sdr
H7R74_RS19470	COG0516	GMP reductase activity
H7R74_RS19470	COG0517	IMP dehydrogenase activity
H7R74_RS19475	COG5413	integral membrane protein
H7R74_RS19485	COG1522	sequence-specific DNA binding
H7R74_RS19490	COG2502	aspartate--ammonia ligase
H7R74_RS19495	COG0542	response to heat
H7R74_RS19505	COG0564	pseudouridine synthase activity
H7R74_RS19510	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R74_RS19515	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R74_RS19525	COG3681	Belongs to the UPF0597 family
H7R74_RS19530	COG2964	Protein conserved in bacteria
H7R74_RS19540	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H7R74_RS19545	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H7R74_RS19550	COG1979	alcohol dehydrogenase
H7R74_RS19555	COG2207	Transcriptional regulator
H7R74_RS19560	COG3040	lipid binding
H7R74_RS19575	COG0583	DNA-binding transcription factor activity
H7R74_RS19595	COG0540	Belongs to the ATCase OTCase family
H7R74_RS19600	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H7R74_RS19605	COG1438	arginine binding
H7R74_RS19610	COG1288	antiporter activity
H7R74_RS19615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7R74_RS19645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7R74_RS19655	COG3078	GTPase activator activity
H7R74_RS19665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7R74_RS19675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7R74_RS19680	COG0408	coproporphyrinogen oxidase activity
H7R74_RS19685	COG0009	L-threonylcarbamoyladenylate synthase
H7R74_RS19695	COG0551	DNA topoisomerase type I activity
H7R74_RS19700	COG2922	Belongs to the Smg family
H7R74_RS19705	COG0758	DNA mediated transformation
H7R74_RS19710	COG1652	LysM domain
H7R74_RS19715	COG0242	peptide deformylase activity
H7R74_RS19720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7R74_RS19725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R74_RS19725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R74_RS19730	COG0569	domain protein
H7R74_RS19735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R74_RS19740	COG1217	gtp-binding protein TYPA
H7R74_RS19745	COG0174	glutamine synthetase
H7R74_RS19765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7R74_RS19770	COG1322	Protein conserved in bacteria
H7R74_RS19790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R74_RS19795	COG0583	DNA-binding transcription factor activity
H7R74_RS19800	COG0519	Catalyzes the synthesis of GMP from XMP
H7R74_RS19800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R74_RS19810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7R74_RS19815	COG1396	sequence-specific DNA binding
H7R74_RS19820	COG1012	belongs to the aldehyde dehydrogenase family
H7R74_RS19830	COG2962	Rard protein
H7R74_RS19840	COG2391	methyltransferase activity
H7R74_RS19850	COG1309	transcriptional regulator
H7R74_RS19865	COG0129	dihydroxy-acid dehydratase activity
H7R74_RS19875	COG3978	acetolactate synthase activity
H7R74_RS19885	COG0606	chelatase, subunit chli
H7R74_RS19890	COG0204	Acyl-transferase
H7R74_RS19895	COG0204	Acyl-transferase
H7R74_RS19900	COG1683	Conserved Protein
H7R74_RS19910	COG1335	isochorismatase
H7R74_RS19920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R74_RS19925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7R74_RS19935	COG3084	Protein conserved in bacteria
H7R74_RS19940	COG5001	Diguanylate cyclase
H7R74_RS19940	COG2203	Gaf domain
H7R74_RS19940	COG4251	negative regulation of phosphorylation
H7R74_RS19940	COG3706	GGDEF domain
H7R74_RS19955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7R74_RS19960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H7R74_RS19965	COG1561	YicC-like family, N-terminal region
H7R74_RS19970	COG0583	DNA-binding transcription factor activity
H7R74_RS19985	COG0583	DNA-binding transcription factor activity
H7R74_RS20025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7R74_RS20030	COG0385	Bile acid
H7R74_RS20035	COG0531	amino acid
H7R74_RS20040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R74_RS20045	COG0531	amino acid
H7R74_RS20050	COG2731	YhcH YjgK YiaL family protein
H7R74_RS20055	COG3250	beta-galactosidase activity
H7R74_RS20060	COG1609	Transcriptional regulator
H7R74_RS20095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7R74_RS20105	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H7R74_RS20110	COG3074	FtsZ-dependent cytokinesis
H7R74_RS20120	COG1045	serine acetyltransferase
H7R74_RS20130	COG0745	RESPONSE REGULATOR receiver
H7R74_RS20135	COG2205	protein histidine kinase activity
H7R74_RS20140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7R74_RS20145	COG0534	Mate efflux family protein
H7R74_RS20160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R74_RS20165	COG2937	Belongs to the GPAT DAPAT family
H7R74_RS20170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7R74_RS20175	COG3161	chorismate lyase activity
H7R74_RS20200	COG0604	alcohol dehydrogenase
H7R74_RS20205	COG1609	Transcriptional regulator
H7R74_RS20210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R74_RS20225	COG1519	Transferase
H7R74_RS20230	COG0859	PFAM glycosyl transferase family 9
H7R74_RS20235	COG0463	Glycosyl transferase, family 2
H7R74_RS20240	COG0859	PFAM glycosyl transferase family 9
H7R74_RS20245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7R74_RS20250	COG2990	Protein conserved in bacteria
H7R74_RS20255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7R74_RS20265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7R74_RS20270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7R74_RS20275	COG2003	Belongs to the UPF0758 family
H7R74_RS20280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7R74_RS20285	COG0756	dUTP diphosphatase activity
H7R74_RS20290	COG1309	transcriptional regulator
H7R74_RS20295	COG0668	transmembrane transport
H7R74_RS20300	COG0166	Belongs to the GPI family
H7R74_RS20305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7R74_RS20325	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R74_RS20325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R74_RS20325	COG1042	CoA-binding domain protein
H7R74_RS20355	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H7R74_RS20360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R74_RS20365	COG1739	Uncharacterized protein family UPF0029
H7R74_RS20370	COG0006	proline dipeptidase activity
H7R74_RS20375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R74_RS20380	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R74_RS20380	COG1024	Enoyl-CoA hydratase
H7R74_RS20385	COG0183	Belongs to the thiolase family
H7R74_RS20410	COG0425	Belongs to the sulfur carrier protein TusA family
H7R74_RS20415	COG0251	oxidation-reduction process
H7R74_RS20420	COG2885	chlorophyll binding
H7R74_RS20425	COG2818	Glycosylase
H7R74_RS20430	COG0752	glycyl-tRNA synthetase alpha subunit
H7R74_RS20435	COG0751	glycine-tRNA ligase activity
H7R74_RS20445	COG2200	EAL domain
H7R74_RS20460	COG2188	Transcriptional regulator
H7R74_RS20475	COG1609	Transcriptional regulator
H7R74_RS20505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R74_RS20520	COG2960	long-chain fatty acid transporting porin activity
H7R74_RS20525	COG5001	Diguanylate cyclase
H7R74_RS20535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7R74_RS20550	COG3118	belongs to the thioredoxin family
H7R74_RS20555	COG0513	Belongs to the DEAD box helicase family
H7R74_RS20560	COG0248	Ppx GppA phosphatase
H7R74_RS20570	COG0742	ribosomal rna small subunit methyltransferase
H7R74_RS20585	COG3469	chitinase activity
H7R74_RS20590	COG3397	chitin binding
H7R74_RS20600	COG0084	hydrolase, TatD family'
H7R74_RS20605	COG0805	protein transport
H7R74_RS20610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R74_RS20615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R74_RS20620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7R74_RS20625	COG3165	ubiquinone biosynthetic process from chorismate
H7R74_RS20630	COG2226	methyltransferase
H7R74_RS20635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7R74_RS20640	COG0402	S-adenosylhomocysteine deaminase activity
H7R74_RS20645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H7R74_RS20685	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H7R74_RS20690	COG0848	biopolymer transport protein
H7R74_RS20695	COG0811	peptide transport
H7R74_RS20700	COG0811	peptide transport
H7R74_RS20710	COG2771	luxR family
H7R74_RS20715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7R74_RS20720	COG1349	DNA-binding transcription factor activity
H7R74_RS20725	COG0745	RESPONSE REGULATOR receiver
H7R74_RS20730	COG2205	protein histidine kinase activity
H7R74_RS20745	COG4452	Inner membrane protein CreD
H7R74_RS20760	COG0297	glycogen (starch) synthase activity
H7R74_RS20760	COG0438	transferase activity, transferring glycosyl groups
H7R74_RS20805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7R74_RS20810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7R74_RS20815	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7R74_RS20820	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7R74_RS20825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7R74_RS20830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7R74_RS20835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7R74_RS20840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7R74_RS20850	COG0356	it plays a direct role in the translocation of protons across the membrane
H7R74_RS20860	COG1475	DNA binding
H7R74_RS20865	COG1192	Involved in chromosome partitioning
H7R74_RS20870	COG0357	Ribosomal RNA small subunit methyltransferase G
H7R74_RS20875	COG0445	tRNA wobble uridine modification
H7R74_RS20880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7R74_RS20890	COG4615	Cyclic peptide transporter
H7R74_RS20895	COG1120	ATPase activity
H7R74_RS20900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R74_RS20910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7R74_RS20915	COG0706	membrane insertase activity
H7R74_RS20920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7R74_RS20925	COG0594	ribonuclease P activity
H7R74_RS20930	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7R74_RS20935	COG1126	abc transporter atp-binding protein
H7R74_RS20970	COG1525	nuclease
H7R74_RS20995	COG1192	Involved in chromosome partitioning
H7R74_RS21045	COG3385	transposase activity
H7R74_RS21070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R74_RS21080	COG0583	DNA-binding transcription factor activity
H7R74_RS21090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R74_RS21095	COG0625	glutathione transferase activity
H7R74_RS21130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R74_RS21150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R74_RS21170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H7R74_RS21180	COG0183	Belongs to the thiolase family
H7R74_RS21290	COG0038	chloride channel
H7R74_RS21310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R74_RS21330	COG0840	transmembrane signaling receptor activity
H7R74_RS21345	COG3385	transposase activity
H7R74_RS21360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7R74_RS21365	COG1061	Type III restriction enzyme res subunit
H7R74_RS21370	COG1002	Type II restriction enzyme, methylase subunits
H7R74_RS21385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7R74_RS21450	COG0640	Transcriptional regulator
H7R74_RS21635	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7R74_RS21640	COG4804	nuclease activity
H7R74_RS21650	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7R74_RS21655	COG4804	nuclease activity
H7R74_RS21665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7R74_RS21680	COG4584	PFAM Integrase catalytic
H7R74_RS21685	COG1484	DNA-dependent DNA replication
H7R74_RS21775	COG2974	May be involved in recombination
H7R74_RS21850	COG3385	transposase activity
H7R74_RS21880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R74_RS21885	COG0625	glutathione transferase activity
H7R74_RS21910	COG1192	Involved in chromosome partitioning
H7R74_RS21935	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R74_RS21940	COG3041	Addiction module toxin RelE StbE family
H7R74_RS21990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R74_RS22040	COG2176	DNA-directed DNA polymerase activity
H7R74_RS22040	COG5002	protein histidine kinase activity
H7R74_RS22115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs