locus-tag	class	description
H7R81_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H7R81_RS00010	COG0592	DNA-directed DNA polymerase activity
H7R81_RS00020	COG0187	DNA topoisomerase II activity
H7R81_RS00035	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7R81_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R81_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
H7R81_RS00050	COG3977	Valine--pyruvate aminotransferase
H7R81_RS00065	COG2814	Major facilitator Superfamily
H7R81_RS00070	COG0745	RESPONSE REGULATOR receiver
H7R81_RS00075	COG2205	protein histidine kinase activity
H7R81_RS00095	COG1733	regulation of RNA biosynthetic process
H7R81_RS00100	COG2267	carboxylic ester hydrolase activity
H7R81_RS00105	COG0604	alcohol dehydrogenase
H7R81_RS00115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R81_RS00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R81_RS00120	COG4191	Histidine kinase
H7R81_RS00125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R81_RS00130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R81_RS00135	COG1309	transcriptional regulator
H7R81_RS00165	COG0469	pyruvate kinase activity
H7R81_RS00170	COG2271	Major facilitator Superfamily
H7R81_RS00195	COG0561	phosphatase activity
H7R81_RS00200	COG2267	carboxylic ester hydrolase activity
H7R81_RS00210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R81_RS00215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R81_RS00220	COG1758	RNA polymerase activity
H7R81_RS00225	COG0194	GDP metabolic process
H7R81_RS00230	COG0859	PFAM glycosyl transferase family 9
H7R81_RS00235	COG3642	lipopolysaccharide core region biosynthetic process
H7R81_RS00275	COG0589	response to stress
H7R81_RS00280	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7R81_RS00285	COG1528	Iron-storage protein
H7R81_RS00290	COG2081	HI0933 family
H7R81_RS00295	COG3275	phosphorelay sensor kinase activity
H7R81_RS00300	COG3279	Response regulator of the LytR AlgR family
H7R81_RS00305	COG2223	nitrite transmembrane transporter activity
H7R81_RS00310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7R81_RS00315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7R81_RS00330	COG0583	DNA-binding transcription factor activity
H7R81_RS00380	COG3012	SEC-C Motif Domain Protein
H7R81_RS00380	COG3318	Belongs to the UPF0149 family
H7R81_RS00395	COG4584	PFAM Integrase catalytic
H7R81_RS00400	COG1484	DNA-dependent DNA replication
H7R81_RS00470	COG2003	Belongs to the UPF0758 family
H7R81_RS00530	COG4983	Phage plasmid primase, P4 family domain protein
H7R81_RS00550	COG1484	DNA-dependent DNA replication
H7R81_RS00555	COG4584	PFAM Integrase catalytic
H7R81_RS00560	COG3039	Transposase
H7R81_RS00565	COG0582	viral genome integration into host DNA
H7R81_RS00570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R81_RS00570	COG1042	CoA-binding domain protein
H7R81_RS00570	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R81_RS00590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7R81_RS00595	COG0166	Belongs to the GPI family
H7R81_RS00600	COG0668	transmembrane transport
H7R81_RS00605	COG1309	transcriptional regulator
H7R81_RS00610	COG0756	dUTP diphosphatase activity
H7R81_RS00615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7R81_RS00620	COG2003	Belongs to the UPF0758 family
H7R81_RS00625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H7R81_RS00630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H7R81_RS00640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H7R81_RS00645	COG2990	Protein conserved in bacteria
H7R81_RS00650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7R81_RS00655	COG0859	PFAM glycosyl transferase family 9
H7R81_RS00660	COG0463	Glycosyl transferase, family 2
H7R81_RS00670	COG0859	PFAM glycosyl transferase family 9
H7R81_RS00675	COG1519	Transferase
H7R81_RS00690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R81_RS00695	COG1609	Transcriptional regulator
H7R81_RS00700	COG0604	alcohol dehydrogenase
H7R81_RS00720	COG3161	chorismate lyase activity
H7R81_RS00725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H7R81_RS00730	COG2937	Belongs to the GPAT DAPAT family
H7R81_RS00735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H7R81_RS00750	COG0534	Mate efflux family protein
H7R81_RS00755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7R81_RS00760	COG2205	protein histidine kinase activity
H7R81_RS00765	COG0745	RESPONSE REGULATOR receiver
H7R81_RS00775	COG1045	serine acetyltransferase
H7R81_RS00785	COG3074	FtsZ-dependent cytokinesis
H7R81_RS00790	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H7R81_RS00795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R81_RS00795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R81_RS00800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7R81_RS00835	COG1609	Transcriptional regulator
H7R81_RS00840	COG3250	beta-galactosidase activity
H7R81_RS00845	COG2731	YhcH YjgK YiaL family protein
H7R81_RS00850	COG0531	amino acid
H7R81_RS00855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R81_RS00860	COG0531	amino acid
H7R81_RS00865	COG3385	transposase activity
H7R81_RS00870	COG0385	Bile acid
H7R81_RS00875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7R81_RS00895	COG0583	DNA-binding transcription factor activity
H7R81_RS00900	COG1561	YicC-like family, N-terminal region
H7R81_RS00910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H7R81_RS00925	COG3706	GGDEF domain
H7R81_RS00925	COG2203	Gaf domain
H7R81_RS00925	COG4251	negative regulation of phosphorylation
H7R81_RS00925	COG5001	Diguanylate cyclase
H7R81_RS00930	COG3084	Protein conserved in bacteria
H7R81_RS00940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H7R81_RS00945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R81_RS00955	COG1335	isochorismatase
H7R81_RS00965	COG1683	Conserved Protein
H7R81_RS00970	COG0204	Acyl-transferase
H7R81_RS00975	COG0204	Acyl-transferase
H7R81_RS00980	COG0606	chelatase, subunit chli
H7R81_RS00990	COG3978	acetolactate synthase activity
H7R81_RS01000	COG0129	dihydroxy-acid dehydratase activity
H7R81_RS01015	COG2391	methyltransferase activity
H7R81_RS01020	COG0840	transmembrane signaling receptor activity
H7R81_RS01025	COG2962	Rard protein
H7R81_RS01035	COG1012	belongs to the aldehyde dehydrogenase family
H7R81_RS01040	COG1396	sequence-specific DNA binding
H7R81_RS01045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7R81_RS01055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R81_RS01055	COG0519	Catalyzes the synthesis of GMP from XMP
H7R81_RS01060	COG0583	DNA-binding transcription factor activity
H7R81_RS01065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R81_RS01090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H7R81_RS01095	COG2204	response regulator
H7R81_RS01110	COG0174	glutamine synthetase
H7R81_RS01115	COG1217	gtp-binding protein TYPA
H7R81_RS01120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R81_RS01125	COG0569	domain protein
H7R81_RS01130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R81_RS01130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R81_RS01135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7R81_RS01140	COG0242	peptide deformylase activity
H7R81_RS01145	COG1652	LysM domain
H7R81_RS01150	COG0758	DNA mediated transformation
H7R81_RS01155	COG2922	Belongs to the Smg family
H7R81_RS01160	COG0551	DNA topoisomerase type I activity
H7R81_RS01170	COG0009	L-threonylcarbamoyladenylate synthase
H7R81_RS01175	COG0408	coproporphyrinogen oxidase activity
H7R81_RS01180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H7R81_RS01190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H7R81_RS01200	COG3078	GTPase activator activity
H7R81_RS01240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7R81_RS01245	COG1288	antiporter activity
H7R81_RS01250	COG1438	arginine binding
H7R81_RS01255	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H7R81_RS01260	COG0540	Belongs to the ATCase OTCase family
H7R81_RS01290	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H7R81_RS01305	COG3040	lipid binding
H7R81_RS01310	COG2207	Transcriptional regulator
H7R81_RS01315	COG1979	alcohol dehydrogenase
H7R81_RS01320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H7R81_RS01325	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H7R81_RS01330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R81_RS01335	COG2964	Protein conserved in bacteria
H7R81_RS01340	COG3681	Belongs to the UPF0597 family
H7R81_RS01350	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R81_RS01355	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R81_RS01360	COG0564	pseudouridine synthase activity
H7R81_RS01370	COG0542	response to heat
H7R81_RS01375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H7R81_RS01380	COG2502	aspartate--ammonia ligase
H7R81_RS01385	COG1522	sequence-specific DNA binding
H7R81_RS01395	COG5413	integral membrane protein
H7R81_RS01400	COG0516	GMP reductase activity
H7R81_RS01400	COG0517	IMP dehydrogenase activity
H7R81_RS01410	COG1028	Short-chain dehydrogenase reductase Sdr
H7R81_RS01425	COG2205	protein histidine kinase activity
H7R81_RS01435	COG2204	response regulator
H7R81_RS01480	COG0243	molybdopterin cofactor binding
H7R81_RS01485	COG3005	denitrification pathway
H7R81_RS01490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R81_RS01490	COG4191	Histidine kinase
H7R81_RS01520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R81_RS01525	COG0569	domain protein
H7R81_RS01530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H7R81_RS01560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R81_RS01575	COG0250	Participates in transcription elongation, termination and antitermination
H7R81_RS01580	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H7R81_RS01585	COG0081	regulation of translation
H7R81_RS01590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H7R81_RS01595	COG0222	ribosome binding
H7R81_RS01600	COG0085	RNA polymerase activity
H7R81_RS01605	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H7R81_RS01610	COG2964	Protein conserved in bacteria
H7R81_RS01620	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R81_RS01625	COG2923	Belongs to the DsrF TusC family
H7R81_RS01630	COG2168	tRNA wobble position uridine thiolation
H7R81_RS01635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H7R81_RS01640	COG0049	tRNA binding
H7R81_RS01645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H7R81_RS01650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H7R81_RS01655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R81_RS01710	COG3714	YhhN family
H7R81_RS01735	COG1301	dicarboxylic acid transport
H7R81_RS01745	COG2095	MarC family integral membrane protein
H7R81_RS01755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R81_RS01765	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R81_RS01775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R81_RS01790	COG1770	oligopeptidase
H7R81_RS01805	COG4221	oxidoreductase activity
H7R81_RS01810	COG0583	DNA-binding transcription factor activity
H7R81_RS01815	COG2249	NAD(P)H dehydrogenase (quinone) activity
H7R81_RS01840	COG0742	ribosomal rna small subunit methyltransferase
H7R81_RS01845	COG0552	protein localization to endoplasmic reticulum
H7R81_RS01850	COG2884	Cell division ATP-binding protein ftsE
H7R81_RS01855	COG2177	Part of the ABC transporter FtsEX involved in
H7R81_RS01865	COG0288	reversible hydration of carbon dioxide
H7R81_RS01870	COG2188	Transcriptional regulator
H7R81_RS01875	COG1228	amidohydrolase
H7R81_RS01880	COG0010	Belongs to the arginase family
H7R81_RS01885	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7R81_RS01890	COG2986	histidine ammonia-lyase
H7R81_RS01895	COG0387	Pfam Sodium calcium exchanger
H7R81_RS01900	COG2200	EAL domain
H7R81_RS01905	COG2199	diguanylate cyclase activity
H7R81_RS01905	COG2200	EAL domain
H7R81_RS01950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R81_RS01955	COG1459	type II secretion system
H7R81_RS01970	COG4969	Belongs to the N-Me-Phe pilin family
H7R81_RS01975	COG4968	Prepilin-type N-terminal cleavage methylation domain
H7R81_RS02000	COG1077	Cell shape determining protein MreB Mrl
H7R81_RS02005	COG1792	Involved in formation and maintenance of cell shape
H7R81_RS02010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7R81_RS02015	COG0424	maF-like protein
H7R81_RS02020	COG1530	ribonuclease E activity
H7R81_RS02025	COG3164	Protein of unknown function
H7R81_RS02035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R81_RS02040	COG0312	modulator of DNA gyrase
H7R81_RS02060	COG0477	Major facilitator Superfamily
H7R81_RS02105	COG0189	ligase activity
H7R81_RS02110	COG0642	Histidine kinase
H7R81_RS02115	COG0745	RESPONSE REGULATOR receiver
H7R81_RS02130	COG0789	Transcriptional regulator
H7R81_RS02135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H7R81_RS02140	COG0352	thiamine-phosphate diphosphorylase activity
H7R81_RS02145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R81_RS02155	COG2022	thiamine diphosphate biosynthetic process
H7R81_RS02160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R81_RS02200	COG0110	maltose O-acetyltransferase activity
H7R81_RS02215	COG0814	amino acid
H7R81_RS02220	COG3932	Exopolysaccharide synthesis, ExoD
H7R81_RS02230	COG3706	GGDEF domain
H7R81_RS02235	COG0004	ammonium transporteR
H7R81_RS02240	COG3133	Outer membrane lipoprotein
H7R81_RS02245	COG0456	acetyltransferase
H7R81_RS02265	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H7R81_RS02270	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H7R81_RS02285	COG0494	nUDIX hydrolase
H7R81_RS02290	COG0628	permease
H7R81_RS02310	COG2957	Belongs to the agmatine deiminase family
H7R81_RS02315	COG0583	DNA-binding transcription factor activity
H7R81_RS02320	COG3284	Transcriptional regulator
H7R81_RS02335	COG1461	Dihydroxyacetone kinase
H7R81_RS02340	COG2376	Dihydroxyacetone kinase
H7R81_RS02350	COG2252	PERMEase
H7R81_RS02355	COG1278	Cold shock
H7R81_RS02365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7R81_RS02380	COG1396	sequence-specific DNA binding
H7R81_RS02410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R81_RS02445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H7R81_RS02455	COG3047	cAMP biosynthetic process
H7R81_RS02460	COG0840	transmembrane signaling receptor activity
H7R81_RS02485	COG3135	benzoate transporter
H7R81_RS02490	COG1396	sequence-specific DNA binding
H7R81_RS02530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R81_RS02530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7R81_RS02545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H7R81_RS02550	COG0038	chloride channel
H7R81_RS02560	COG0316	Belongs to the HesB IscA family
H7R81_RS02565	COG1757	Na H antiporter
H7R81_RS02605	COG0297	glycogen (starch) synthase activity
H7R81_RS02610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7R81_RS02615	COG2813	Specifically methylates the guanine in position
H7R81_RS02620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R81_RS02630	COG1392	Phosphate transport regulator
H7R81_RS02635	COG0306	phosphate transporter
H7R81_RS02640	COG0460	homoserine dehydrogenase
H7R81_RS02640	COG0527	aspartate kinase activity
H7R81_RS02645	COG0626	cystathionine gamma-synthase activity
H7R81_RS02655	COG0814	amino acid
H7R81_RS02660	COG1218	3'(2'),5'-bisphosphate nucleotidase
H7R81_RS02665	COG0494	nUDIX hydrolase
H7R81_RS02670	COG1011	Hydrolase
H7R81_RS02685	COG0110	maltose O-acetyltransferase activity
H7R81_RS02690	COG3174	membrane
H7R81_RS02695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H7R81_RS02705	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H7R81_RS02710	COG4208	sulfate ABC transporter
H7R81_RS02715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H7R81_RS02720	COG0583	DNA-binding transcription factor activity
H7R81_RS02725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7R81_RS02730	COG0765	amino acid transport
H7R81_RS02740	COG1126	abc transporter atp-binding protein
H7R81_RS02745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R81_RS02750	COG3397	chitin binding
H7R81_RS02755	COG0840	transmembrane signaling receptor activity
H7R81_RS02770	COG1649	PFAM Uncharacterised BCR, COG1649
H7R81_RS02770	COG0726	polysaccharide deacetylase
H7R81_RS02775	COG1215	transferase activity, transferring glycosyl groups
H7R81_RS02790	COG0633	Ferredoxin
H7R81_RS02790	COG0543	2 iron, 2 sulfur cluster binding
H7R81_RS02805	COG1328	CTP reductase activity
H7R81_RS02810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R81_RS02825	COG1448	Aminotransferase
H7R81_RS02865	COG0513	Belongs to the DEAD box helicase family
H7R81_RS02890	COG3112	Uncharacterised protein family (UPF0231)
H7R81_RS02900	COG3835	regulator
H7R81_RS02905	COG2610	gluconate transmembrane transporter activity
H7R81_RS02910	COG1929	Belongs to the glycerate kinase type-1 family
H7R81_RS02930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R81_RS02940	COG1872	DUF167
H7R81_RS02945	COG0762	integral membrane protein
H7R81_RS02950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7R81_RS02955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7R81_RS02970	COG3022	response to hydroperoxide
H7R81_RS02990	COG0347	Belongs to the P(II) protein family
H7R81_RS02995	COG1840	ABC-type Fe3 transport system, periplasmic component
H7R81_RS03005	COG3842	ATPase activity
H7R81_RS03010	COG2837	iron assimilation
H7R81_RS03015	COG1438	arginine binding
H7R81_RS03020	COG1126	abc transporter atp-binding protein
H7R81_RS03025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R81_RS03030	COG4215	(ABC) transporter
H7R81_RS03035	COG4160	amino acid transport
H7R81_RS03040	COG0039	L-malate dehydrogenase activity
H7R81_RS03045	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H7R81_RS03050	COG1017	nitric oxide dioxygenase activity
H7R81_RS03050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R81_RS03060	COG4536	flavin adenine dinucleotide binding
H7R81_RS03065	COG4137	Cytochrome C assembly protein
H7R81_RS03070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7R81_RS03075	COG0228	four-way junction DNA binding
H7R81_RS03080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H7R81_RS03085	COG0336	Belongs to the RNA methyltransferase TrmD family
H7R81_RS03090	COG0335	large ribosomal subunit rRNA binding
H7R81_RS03100	COG3066	DNA modification
H7R81_RS03105	COG1051	belongs to the nudix hydrolase family
H7R81_RS03115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H7R81_RS03120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H7R81_RS03125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R81_RS03135	COG0583	DNA-binding transcription factor activity
H7R81_RS03140	COG0640	Transcriptional regulator
H7R81_RS03145	COG0268	Binds directly to 16S ribosomal RNA
H7R81_RS03150	COG0728	peptidoglycan biosynthetic process
H7R81_RS03155	COG0196	riboflavin kinase activity
H7R81_RS03160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H7R81_RS03165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H7R81_RS03170	COG1047	Peptidyl-prolyl cis-trans
H7R81_RS03175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H7R81_RS03215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7R81_RS03215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7R81_RS03230	COG1854	S-ribosylhomocysteine lyase activity
H7R81_RS03240	COG2165	general secretion pathway protein
H7R81_RS03245	COG0084	hydrolase, TatD family'
H7R81_RS03250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R81_RS03260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H7R81_RS03265	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7R81_RS03270	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H7R81_RS03280	COG3447	MASE1 domain protein
H7R81_RS03280	COG5001	Diguanylate cyclase
H7R81_RS03280	COG5002	protein histidine kinase activity
H7R81_RS03290	COG0560	Phosphoserine phosphatase
H7R81_RS03305	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H7R81_RS03310	COG3385	transposase activity
H7R81_RS03325	COG0776	regulation of translation
H7R81_RS03335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7R81_RS03340	COG1914	H( )-stimulated, divalent metal cation uptake system
H7R81_RS03345	COG0360	Binds together with S18 to 16S ribosomal RNA
H7R81_RS03350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H7R81_RS03355	COG0359	binds to the 23S rRNA
H7R81_RS03360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R81_RS03385	COG1064	alcohol dehydrogenase
H7R81_RS03390	COG1238	metal cluster binding
H7R81_RS03395	COG0612	Peptidase, M16
H7R81_RS03400	COG2918	glutathione biosynthetic process
H7R81_RS03410	COG1022	Amp-dependent synthetase and ligase
H7R81_RS03420	COG0456	acetyltransferase
H7R81_RS03445	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H7R81_RS03465	COG0477	Major facilitator Superfamily
H7R81_RS03470	COG0583	DNA-binding transcription factor activity
H7R81_RS03475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R81_RS03480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7R81_RS03490	COG0673	inositol 2-dehydrogenase activity
H7R81_RS03500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H7R81_RS03505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7R81_RS03510	COG3036	rescue of stalled ribosome
H7R81_RS03520	COG0138	bifunctional purine biosynthesis protein purh
H7R81_RS03525	COG0151	Belongs to the GarS family
H7R81_RS03550	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7R81_RS03580	COG0582	viral genome integration into host DNA
H7R81_RS03590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7R81_RS03595	COG0358	DNA primase activity
H7R81_RS03600	COG1610	YqeY-like protein
H7R81_RS03605	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H7R81_RS03610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H7R81_RS03615	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R81_RS03620	COG1027	Aspartate ammonia-lyase
H7R81_RS03625	COG3030	protein affecting phage T7 exclusion by the F plasmid
H7R81_RS03630	COG0534	Mate efflux family protein
H7R81_RS03635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H7R81_RS03640	COG0459	protein refolding
H7R81_RS03695	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H7R81_RS03700	COG3385	transposase activity
H7R81_RS03705	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H7R81_RS03710	COG1178	ABC-type Fe3 transport system permease component
H7R81_RS03715	COG4143	(ABC) transporter
H7R81_RS03730	COG0066	3-isopropylmalate dehydratase activity
H7R81_RS03735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H7R81_RS03740	COG0473	3-isopropylmalate dehydrogenase activity
H7R81_RS03745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H7R81_RS03770	COG0028	Belongs to the TPP enzyme family
H7R81_RS03775	COG0440	acetolactate synthase activity
H7R81_RS03815	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H7R81_RS03830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R81_RS03860	COG0745	RESPONSE REGULATOR receiver
H7R81_RS03865	COG3104	oligopeptide transport
H7R81_RS03870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7R81_RS03875	COG1555	photosystem II stabilization
H7R81_RS03880	COG0280	phosphate acetyltransferase
H7R81_RS03880	COG0857	belongs to the CobB CobQ family
H7R81_RS03885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R81_RS03895	COG3013	Belongs to the UPF0304 family
H7R81_RS03900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7R81_RS03905	COG2716	regulation of RNA biosynthetic process
H7R81_RS03910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7R81_RS03915	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H7R81_RS03920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7R81_RS03955	COG0784	Response regulator, receiver
H7R81_RS03955	COG2198	Histidine kinase
H7R81_RS03955	COG5002	protein histidine kinase activity
H7R81_RS03960	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H7R81_RS03990	COG1464	Belongs to the NlpA lipoprotein family
H7R81_RS03995	COG2011	ABC-type metal ion transport system permease component
H7R81_RS04000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7R81_RS04020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7R81_RS04020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H7R81_RS04025	COG0802	atpase or kinase
H7R81_RS04040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H7R81_RS04045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H7R81_RS04050	COG1923	regulation of RNA biosynthetic process
H7R81_RS04055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7R81_RS04060	COG0330	HflC and HflK could
H7R81_RS04065	COG0330	HflC and HflK could
H7R81_RS04070	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H7R81_RS04075	COG0142	geranyltranstransferase activity
H7R81_RS04080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H7R81_RS04085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7R81_RS04090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H7R81_RS04095	COG3314	Sporulation integral membrane protein YlbJ
H7R81_RS04105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7R81_RS04115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7R81_RS04120	COG2967	ApaG domain
H7R81_RS04125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H7R81_RS04130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H7R81_RS04135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R81_RS04140	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H7R81_RS04145	COG3178	'Phosphotransferase
H7R81_RS04150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7R81_RS04155	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R81_RS04160	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R81_RS04165	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H7R81_RS04170	COG1073	alpha beta
H7R81_RS04185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7R81_RS04190	COG3385	transposase activity
H7R81_RS04205	COG4628	conserved protein (DUF2132)
H7R81_RS04210	COG0688	phosphatidylethanolamine metabolic process
H7R81_RS04220	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H7R81_RS04260	COG1278	Cold shock
H7R81_RS04270	COG0840	transmembrane signaling receptor activity
H7R81_RS04275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R81_RS04280	COG2252	PERMEase
H7R81_RS04290	COG0488	(ABC) transporter
H7R81_RS04305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7R81_RS04310	COG0741	lytic transglycosylase activity
H7R81_RS04350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R81_RS04355	COG4991	sh3 domain protein
H7R81_RS04365	COG2816	NAD+ diphosphatase activity
H7R81_RS04370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H7R81_RS04375	COG1940	carbohydrate kinase activity
H7R81_RS04380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R81_RS04385	COG0126	phosphoglycerate kinase activity
H7R81_RS04390	COG0191	fructose-bisphosphate aldolase activity
H7R81_RS04395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R81_RS04435	COG0354	folic acid binding
H7R81_RS04440	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H7R81_RS04450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H7R81_RS04455	COG1595	DNA-templated transcription, initiation
H7R81_RS04460	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H7R81_RS04465	COG3026	antisigma factor binding
H7R81_RS04475	COG0481	GTPase activity
H7R81_RS04480	COG0681	Belongs to the peptidase S26 family
H7R81_RS04485	COG0571	ribonuclease III activity
H7R81_RS04495	COG1381	Involved in DNA repair and RecF pathway recombination
H7R81_RS04500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H7R81_RS04510	COG2350	Protein conserved in bacteria
H7R81_RS04515	COG2917	probably involved in intracellular septation
H7R81_RS04520	COG0076	glutamate decarboxylase activity
H7R81_RS04525	COG1272	protein, Hemolysin III
H7R81_RS04530	COG2985	domain, Protein
H7R81_RS04530	COG0569	domain protein
H7R81_RS04565	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
H7R81_RS04575	COG4251	negative regulation of phosphorylation
H7R81_RS04575	COG2203	Gaf domain
H7R81_RS04575	COG3706	GGDEF domain
H7R81_RS04575	COG5001	Diguanylate cyclase
H7R81_RS04610	COG4974	Belongs to the 'phage' integrase family
H7R81_RS04630	COG0582	viral genome integration into host DNA
H7R81_RS04650	COG1858	cytochrome C peroxidase
H7R81_RS04660	COG2313	pseudouridylate synthase activity
H7R81_RS04665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R81_RS04705	COG1765	OsmC-like protein
H7R81_RS04720	COG3954	Phosphoribulokinase
H7R81_RS04725	COG3089	Belongs to the UPF0270 family
H7R81_RS04730	COG3706	GGDEF domain
H7R81_RS04735	COG0429	hydrolase of the alpha beta-hydrolase fold
H7R81_RS04740	COG0784	Response regulator, receiver
H7R81_RS04740	COG0835	chemotaxis
H7R81_RS04750	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H7R81_RS04755	COG1047	Peptidyl-prolyl cis-trans
H7R81_RS04770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R81_RS04780	COG3340	Belongs to the peptidase S51 family
H7R81_RS04785	COG1966	Carbon starvation protein
H7R81_RS04790	COG3279	Response regulator of the LytR AlgR family
H7R81_RS04795	COG3275	phosphorelay sensor kinase activity
H7R81_RS04810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R81_RS04820	COG3721	Heme iron utilization protein
H7R81_RS04825	COG0748	coenzyme F420 binding
H7R81_RS04850	COG2814	Major facilitator Superfamily
H7R81_RS04855	COG3385	transposase activity
H7R81_RS04865	COG3655	Transcriptional regulator
H7R81_RS04875	COG5002	protein histidine kinase activity
H7R81_RS04875	COG2205	protein histidine kinase activity
H7R81_RS04875	COG0784	Response regulator, receiver
H7R81_RS04905	COG3397	chitin binding
H7R81_RS04945	COG0784	Response regulator, receiver
H7R81_RS04945	COG0835	chemotaxis
H7R81_RS04950	COG2755	lipolytic protein G-D-S-L family
H7R81_RS04955	COG4181	ATPase activity
H7R81_RS04960	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H7R81_RS04965	COG1090	epimerase
H7R81_RS04970	COG2200	EAL domain
H7R81_RS04975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R81_RS04980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H7R81_RS04985	COG3171	Protein conserved in bacteria
H7R81_RS04990	COG2066	Belongs to the glutaminase family
H7R81_RS04995	COG2897	thiosulfate sulfurtransferase activity
H7R81_RS05010	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R81_RS05020	COG2966	Psort location CytoplasmicMembrane, score
H7R81_RS05035	COG4175	Glycine betaine
H7R81_RS05040	COG4176	ABC-type proline glycine betaine transport system permease component
H7R81_RS05045	COG2113	Glycine betaine
H7R81_RS05050	COG0175	sulfate reduction
H7R81_RS05055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R81_RS05060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7R81_RS05065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H7R81_RS05080	COG5001	Diguanylate cyclase
H7R81_RS05095	COG0786	glutamate:sodium symporter activity
H7R81_RS05100	COG0252	asparaginase activity
H7R81_RS05105	COG3139	Protein of unknown function (DUF1315)
H7R81_RS05125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H7R81_RS05130	COG0321	lipoyl(octanoyl) transferase activity
H7R81_RS05135	COG2921	Belongs to the UPF0250 family
H7R81_RS05140	COG1686	Belongs to the peptidase S11 family
H7R81_RS05145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7R81_RS05150	COG2951	lytic endotransglycosylase activity
H7R81_RS05155	COG0772	Belongs to the SEDS family
H7R81_RS05160	COG0772	Belongs to the SEDS family
H7R81_RS05165	COG0768	penicillin binding
H7R81_RS05170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H7R81_RS05175	COG0799	negative regulation of ribosome biogenesis
H7R81_RS05180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H7R81_RS05195	COG0495	leucyl-tRNA aminoacylation
H7R81_RS05200	COG2888	peptidyl-tyrosine sulfation
H7R81_RS05205	COG0312	modulator of DNA gyrase
H7R81_RS05215	COG0716	FMN binding
H7R81_RS05220	COG4974	Belongs to the 'phage' integrase family
H7R81_RS05225	COG1970	mechanosensitive ion channel activity
H7R81_RS05240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H7R81_RS05245	COG4535	Mg2 and Co2 transporter CorC
H7R81_RS05250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H7R81_RS05255	COG1702	phosphate starvation-inducible protein PhoH
H7R81_RS05260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R81_RS05265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R81_RS05275	COG3706	GGDEF domain
H7R81_RS05280	COG0583	DNA-binding transcription factor activity
H7R81_RS05305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R81_RS05315	COG3647	Membrane
H7R81_RS05320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H7R81_RS05330	COG0516	GMP reductase activity
H7R81_RS05340	COG0642	Histidine kinase
H7R81_RS05355	COG4221	oxidoreductase activity
H7R81_RS05365	COG1022	Amp-dependent synthetase and ligase
H7R81_RS05380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R81_RS05385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R81_RS05395	COG1309	transcriptional regulator
H7R81_RS05400	COG3214	Protein conserved in bacteria
H7R81_RS05410	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R81_RS05415	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7R81_RS05420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7R81_RS05425	COG1053	succinate dehydrogenase
H7R81_RS05435	COG0584	glycerophosphoryl diester phosphodiesterase
H7R81_RS05440	COG1511	domain protein
H7R81_RS05440	COG3264	Mechanosensitive ion channel
H7R81_RS05450	COG0739	heme binding
H7R81_RS05460	COG0583	DNA-binding transcription factor activity
H7R81_RS05480	COG0583	DNA-binding transcription factor activity
H7R81_RS05485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H7R81_RS05515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H7R81_RS05520	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H7R81_RS05530	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H7R81_RS05535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7R81_RS05545	COG0180	Tryptophanyl-tRNA synthetase
H7R81_RS05555	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R81_RS05560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H7R81_RS05570	COG1012	belongs to the aldehyde dehydrogenase family
H7R81_RS05585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R81_RS05600	COG0488	(ABC) transporter
H7R81_RS05605	COG0366	Alpha amylase catalytic
H7R81_RS05615	COG0657	acetylesterase activity
H7R81_RS05620	COG3097	Belongs to the UPF0267 family
H7R81_RS05630	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H7R81_RS05640	COG0471	metal ion transport
H7R81_RS05640	COG0490	domain, Protein
H7R81_RS05685	COG0012	GTP binding
H7R81_RS05690	COG0193	aminoacyl-tRNA hydrolase activity
H7R81_RS05695	COG0737	Belongs to the 5'-nucleotidase family
H7R81_RS05700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H7R81_RS05710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H7R81_RS05715	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H7R81_RS05720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H7R81_RS05725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H7R81_RS05730	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R81_RS05740	COG2912	Transglutaminase-like superfamily
H7R81_RS05745	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H7R81_RS05765	COG0095	Lipoate-protein ligase
H7R81_RS05770	COG2233	PERMEase
H7R81_RS05785	COG0534	Mate efflux family protein
H7R81_RS05795	COG0281	malic enzyme
H7R81_RS05825	COG0733	neurotransmitter:sodium symporter activity
H7R81_RS05830	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R81_RS05835	COG3706	GGDEF domain
H7R81_RS05840	COG1566	PFAM secretion protein HlyD family protein
H7R81_RS05850	COG1032	radical SAM domain protein
H7R81_RS05875	COG0673	inositol 2-dehydrogenase activity
H7R81_RS05880	COG2920	part of a sulfur-relay system
H7R81_RS05885	COG1289	transmembrane transporter activity
H7R81_RS05890	COG0670	Belongs to the BI1 family
H7R81_RS05910	COG1486	melibiose metabolic process
H7R81_RS05915	COG2169	Transcriptional regulator
H7R81_RS05915	COG1917	Cupin 2, conserved barrel domain protein
H7R81_RS05920	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7R81_RS05925	COG2723	6-phospho-beta-galactosidase activity
H7R81_RS05930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7R81_RS05935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7R81_RS05950	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H7R81_RS05960	COG3156	type II secretion system protein K
H7R81_RS05965	COG4795	General secretion pathway protein
H7R81_RS05970	COG2165	general secretion pathway protein
H7R81_RS05985	COG2165	general secretion pathway protein
H7R81_RS05990	COG1459	type II secretion system
H7R81_RS05995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R81_RS06015	COG3267	Type II secretory pathway component ExeA
H7R81_RS06015	COG3409	Peptidoglycan-binding domain 1 protein
H7R81_RS06020	COG3437	response regulator, receiver
H7R81_RS06020	COG2770	Histidine kinase
H7R81_RS06035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7R81_RS06040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H7R81_RS06045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R81_RS06055	COG2190	(PTS) system
H7R81_RS06065	COG3264	Mechanosensitive ion channel
H7R81_RS06065	COG1196	nuclear chromosome segregation
H7R81_RS06070	COG0469	pyruvate kinase activity
H7R81_RS06080	COG3384	dioxygenase
H7R81_RS06085	COG0419	ATPase involved in DNA repair
H7R81_RS06090	COG0420	3'-5' exonuclease activity
H7R81_RS06100	COG2974	May be involved in recombination
H7R81_RS06120	COG0531	amino acid
H7R81_RS06130	COG0531	amino acid
H7R81_RS06145	COG1917	Cupin 2, conserved barrel domain protein
H7R81_RS06145	COG1396	sequence-specific DNA binding
H7R81_RS06150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R81_RS06170	COG0464	growth
H7R81_RS06205	COG3038	cytochrome b561
H7R81_RS06215	COG1720	tRNA m6t6A37 methyltransferase activity
H7R81_RS06235	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7R81_RS06240	COG4988	ABC transporter
H7R81_RS06255	COG0745	RESPONSE REGULATOR receiver
H7R81_RS06265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R81_RS06285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R81_RS06290	COG3550	peptidyl-serine autophosphorylation
H7R81_RS06295	COG1396	sequence-specific DNA binding
H7R81_RS06300	COG1988	membrane-bound metal-dependent
H7R81_RS06315	COG0159	tryptophan synthase activity
H7R81_RS06320	COG0133	tryptophan synthase activity
H7R81_RS06325	COG0135	phosphoribosylanthranilate isomerase activity
H7R81_RS06325	COG0134	indole-3-glycerol-phosphate synthase activity
H7R81_RS06330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R81_RS06335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H7R81_RS06335	COG0512	Glutamine amidotransferase of anthranilate synthase
H7R81_RS06340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7R81_RS06350	COG0009	L-threonylcarbamoyladenylate synthase
H7R81_RS06360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7R81_RS06370	COG1946	Acyl-CoA thioesterase
H7R81_RS06375	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H7R81_RS06380	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7R81_RS06390	COG0083	homoserine kinase activity
H7R81_RS06395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7R81_RS06405	COG1943	Transposase
H7R81_RS06415	COG0675	Transposase, IS605 OrfB family
H7R81_RS06425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H7R81_RS06445	COG1342	Belongs to the UPF0251 family
H7R81_RS06460	COG1309	transcriptional regulator
H7R81_RS06465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R81_RS06470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R81_RS06495	COG1091	dTDP-4-dehydrorhamnose reductase activity
H7R81_RS06525	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H7R81_RS06545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R81_RS06570	COG0438	transferase activity, transferring glycosyl groups
H7R81_RS06585	COG3754	Rhamnan synthesis protein F
H7R81_RS06590	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H7R81_RS06595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R81_RS06600	COG1051	belongs to the nudix hydrolase family
H7R81_RS06605	COG0662	Cupin 2, conserved barrel domain protein
H7R81_RS06605	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H7R81_RS06640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R81_RS06655	COG1484	DNA-dependent DNA replication
H7R81_RS06660	COG4584	PFAM Integrase catalytic
H7R81_RS06670	COG1484	DNA-dependent DNA replication
H7R81_RS06685	COG1136	(ABC) transporter
H7R81_RS06685	COG0577	efflux transmembrane transporter activity
H7R81_RS06690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R81_RS06705	COG3328	transposase activity
H7R81_RS06715	COG0675	Transposase, IS605 OrfB family
H7R81_RS06720	COG1227	inorganic diphosphatase activity
H7R81_RS06725	COG0497	DNA recombination
H7R81_RS06730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H7R81_RS06735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H7R81_RS06740	COG0443	Heat shock 70 kDa protein
H7R81_RS06745	COG0484	heat shock protein binding
H7R81_RS06775	COG1285	pathogenesis
H7R81_RS06815	COG1566	PFAM secretion protein HlyD family protein
H7R81_RS06820	COG0577	efflux transmembrane transporter activity
H7R81_RS06820	COG1136	(ABC) transporter
H7R81_RS06825	COG0577	efflux transmembrane transporter activity
H7R81_RS06825	COG1136	(ABC) transporter
H7R81_RS06830	COG1136	(ABC) transporter
H7R81_RS06830	COG0577	efflux transmembrane transporter activity
H7R81_RS06840	COG0095	Lipoate-protein ligase
H7R81_RS06850	COG0702	epimerase
H7R81_RS06855	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R81_RS06860	COG1454	alcohol dehydrogenase
H7R81_RS06870	COG0564	pseudouridine synthase activity
H7R81_RS06905	COG1280	lysine exporter protein (LysE YggA)
H7R81_RS06920	COG3263	regulation of cellular component size
H7R81_RS06930	COG1876	peptidase activity
H7R81_RS06935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7R81_RS06940	COG1393	Belongs to the ArsC family
H7R81_RS06950	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R81_RS06955	COG1473	amidohydrolase
H7R81_RS06965	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7R81_RS06975	COG0017	Asparaginyl-tRNA synthetase
H7R81_RS06990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7R81_RS06995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7R81_RS07000	COG0156	8-amino-7-oxononanoate synthase activity
H7R81_RS07005	COG2267	carboxylic ester hydrolase activity
H7R81_RS07005	COG2226	methyltransferase
H7R81_RS07010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7R81_RS07015	COG0501	Belongs to the peptidase M48B family
H7R81_RS07025	COG3217	Mosc domain protein beta barrel domain protein
H7R81_RS07025	COG0633	Ferredoxin
H7R81_RS07025	COG3217	Mosc domain protein beta barrel domain protein
H7R81_RS07025	COG0633	Ferredoxin
H7R81_RS07040	COG0674	pyruvate-flavodoxin oxidoreductase activity
H7R81_RS07040	COG1013	pyruvate-flavodoxin oxidoreductase activity
H7R81_RS07040	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H7R81_RS07040	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H7R81_RS07050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R81_RS07055	COG1607	acyl-coa hydrolase
H7R81_RS07065	COG3021	interspecies interaction between organisms
H7R81_RS07070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7R81_RS07075	COG2027	D-alanyl-D-alanine carboxypeptidase
H7R81_RS07090	COG1566	PFAM secretion protein HlyD family protein
H7R81_RS07100	COG1966	Carbon starvation protein
H7R81_RS07105	COG3279	Response regulator of the LytR AlgR family
H7R81_RS07110	COG3275	phosphorelay sensor kinase activity
H7R81_RS07115	COG2199	diguanylate cyclase activity
H7R81_RS07115	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R81_RS07120	COG2194	sulfuric ester hydrolase activity
H7R81_RS07125	COG1940	carbohydrate kinase activity
H7R81_RS07125	COG1846	Transcriptional regulator
H7R81_RS07130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R81_RS07135	COG0363	glucosamine-6-phosphate deaminase activity
H7R81_RS07140	COG2190	(PTS) system
H7R81_RS07140	COG1263	PTS System
H7R81_RS07140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R81_RS07150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R81_RS07155	COG0735	belongs to the Fur family
H7R81_RS07165	COG0716	FMN binding
H7R81_RS07180	COG0596	Alpha beta hydrolase
H7R81_RS07185	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H7R81_RS07190	COG0033	Phosphoglucomutase
H7R81_RS07195	COG2951	lytic endotransglycosylase activity
H7R81_RS07200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7R81_RS07205	COG4136	ATPase activity
H7R81_RS07215	COG4134	Bacterial extracellular solute-binding protein
H7R81_RS07225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7R81_RS07235	COG0675	Transposase, IS605 OrfB family
H7R81_RS07245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R81_RS07255	COG0729	surface antigen
H7R81_RS07260	COG2911	Protein conserved in bacteria
H7R81_RS07280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H7R81_RS07290	COG0741	lytic transglycosylase activity
H7R81_RS07300	COG4771	TonB-dependent receptor
H7R81_RS07325	COG1278	Cold shock
H7R81_RS07350	COG0697	spore germination
H7R81_RS07355	COG1349	DNA-binding transcription factor activity
H7R81_RS07360	COG1882	Formate acetyltransferase
H7R81_RS07365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R81_RS07370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R81_RS07385	COG1187	pseudouridine synthase activity
H7R81_RS07395	COG4166	transmembrane transport
H7R81_RS07400	COG0622	Phosphoesterase
H7R81_RS07415	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
H7R81_RS07420	COG0835	chemotaxis
H7R81_RS07420	COG0784	Response regulator, receiver
H7R81_RS07425	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H7R81_RS07430	COG1815	bacterial-type flagellum-dependent cell motility
H7R81_RS07440	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H7R81_RS07450	COG4787	bacterial-type flagellum-dependent cell motility
H7R81_RS07460	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H7R81_RS07465	COG1706	bacterial-type flagellum-dependent cell motility
H7R81_RS07480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H7R81_RS07485	COG2239	Acts as a magnesium transporter
H7R81_RS07495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H7R81_RS07500	COG2716	regulation of RNA biosynthetic process
H7R81_RS07525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H7R81_RS07530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7R81_RS07535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7R81_RS07540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H7R81_RS07560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7R81_RS07575	COG0590	tRNA wobble adenosine to inosine editing
H7R81_RS07580	COG0573	inorganic phosphate transmembrane transporter activity
H7R81_RS07585	COG0581	inorganic phosphate transmembrane transporter activity
H7R81_RS07590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7R81_RS07595	COG0704	Plays a role in the regulation of phosphate uptake
H7R81_RS07600	COG1253	flavin adenine dinucleotide binding
H7R81_RS07615	COG0531	amino acid
H7R81_RS07630	COG1126	abc transporter atp-binding protein
H7R81_RS07635	COG0765	amino acid transport
H7R81_RS07640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R81_RS07645	COG3706	GGDEF domain
H7R81_RS07650	COG2271	Major facilitator Superfamily
H7R81_RS07660	COG2197	response regulator
H7R81_RS07665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R81_RS07685	COG1785	Belongs to the alkaline phosphatase family
H7R81_RS07690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7R81_RS07700	COG3385	transposase activity
H7R81_RS07710	COG1199	ATP-dependent helicase activity
H7R81_RS07730	COG0287	Prephenate dehydrogenase
H7R81_RS07730	COG1605	Chorismate mutase
H7R81_RS07735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R81_RS07745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R81_RS07750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R81_RS07785	COG0537	adenosine 5'-monophosphoramidase activity
H7R81_RS07800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H7R81_RS07815	COG1301	dicarboxylic acid transport
H7R81_RS07825	COG2354	Protein conserved in bacteria
H7R81_RS07835	COG2233	PERMEase
H7R81_RS07840	COG3150	esterase
H7R81_RS07845	COG1252	NADH dehydrogenase
H7R81_RS07855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7R81_RS07860	COG3300	MHYT domain
H7R81_RS07860	COG5001	Diguanylate cyclase
H7R81_RS07865	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R81_RS07875	COG2373	Large extracellular alpha-helical protein
H7R81_RS07880	COG4953	penicillin-binding protein 1C
H7R81_RS07895	COG0301	tRNA thio-modification
H7R81_RS07895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R81_RS07900	COG3385	transposase activity
H7R81_RS07975	COG1083	cytidylyl-transferase
H7R81_RS08005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R81_RS08015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R81_RS08030	COG1106	Psort location Cytoplasmic, score
H7R81_RS08070	COG3385	transposase activity
H7R81_RS08075	COG2119	membrane
H7R81_RS08080	COG0023	Translation Initiation Factor
H7R81_RS08105	COG0513	Belongs to the DEAD box helicase family
H7R81_RS08115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R81_RS08120	COG0765	amino acid transport
H7R81_RS08125	COG1126	abc transporter atp-binding protein
H7R81_RS08130	COG0493	'glutamate synthase
H7R81_RS08135	COG0069	glutamate synthase activity
H7R81_RS08135	COG0067	glutamate synthase
H7R81_RS08135	COG0070	glutamate synthase
H7R81_RS08140	COG1242	4 iron, 4 sulfur cluster binding
H7R81_RS08210	COG3634	alkyl hydroperoxide reductase activity
H7R81_RS08220	COG0517	IMP dehydrogenase activity
H7R81_RS08225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H7R81_RS08230	COG0343	queuine tRNA-ribosyltransferase activity
H7R81_RS08235	COG1862	Preprotein translocase
H7R81_RS08240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R81_RS08245	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7R81_RS08250	COG2897	thiosulfate sulfurtransferase activity
H7R81_RS08260	COG0826	peptidase U32
H7R81_RS08265	COG0826	peptidase U32
H7R81_RS08270	COG3154	lipid carrier protein
H7R81_RS08290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7R81_RS08295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7R81_RS08295	COG0574	Belongs to the PEP-utilizing enzyme family
H7R81_RS08300	COG2207	Transcriptional regulator
H7R81_RS08320	COG1464	Belongs to the NlpA lipoprotein family
H7R81_RS08325	COG3083	sulfuric ester hydrolase activity
H7R81_RS08330	COG3082	Protein of unknown function (DUF1414)
H7R81_RS08335	COG3081	Nucleoid-associated protein
H7R81_RS08345	COG1175	transmembrane transport
H7R81_RS08350	COG3833	ABC-type maltose transport systems, permease component
H7R81_RS08355	COG3842	ATPase activity
H7R81_RS08380	COG0425	Belongs to the sulfur carrier protein TusA family
H7R81_RS08385	COG4783	chaperone-mediated protein folding
H7R81_RS08390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R81_RS08395	COG1393	Belongs to the ArsC family
H7R81_RS08405	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H7R81_RS08410	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H7R81_RS08415	COG2431	L-lysine efflux transmembrane transporter activity
H7R81_RS08425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R81_RS08435	COG4160	amino acid transport
H7R81_RS08440	COG0564	pseudouridine synthase activity
H7R81_RS08455	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H7R81_RS08465	COG0625	glutathione transferase activity
H7R81_RS08475	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R81_RS08480	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R81_RS08490	COG0367	asparagine synthase
H7R81_RS08500	COG4651	solute:proton antiporter activity
H7R81_RS08500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7R81_RS08505	COG0647	UMP catabolic process
H7R81_RS08540	COG1902	pentaerythritol trinitrate reductase activity
H7R81_RS08545	COG1253	flavin adenine dinucleotide binding
H7R81_RS08555	COG0247	lactate metabolic process
H7R81_RS08555	COG0277	FAD linked oxidase domain protein
H7R81_RS08565	COG2050	protein possibly involved in aromatic compounds catabolism
H7R81_RS08570	COG0513	Belongs to the DEAD box helicase family
H7R81_RS08575	COG2056	Na+-H+ antiporter family
H7R81_RS08580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R81_RS08585	COG0671	phosphoesterase, PA-phosphatase related
H7R81_RS08590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R81_RS08595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R81_RS08605	COG0101	tRNA pseudouridine synthase activity
H7R81_RS08610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7R81_RS08615	COG0285	dihydrofolate synthase activity
H7R81_RS08620	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H7R81_RS08625	COG0393	Putative heavy-metal-binding
H7R81_RS08635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R81_RS08635	COG1648	precorrin-2 dehydrogenase activity
H7R81_RS08655	COG4667	esterase of the alpha-beta hydrolase superfamily
H7R81_RS08660	COG1368	sulfuric ester hydrolase activity
H7R81_RS08670	COG0527	aspartate kinase activity
H7R81_RS08675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R81_RS08675	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H7R81_RS08680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H7R81_RS08700	COG0596	Alpha beta hydrolase
H7R81_RS08715	COG0577	efflux transmembrane transporter activity
H7R81_RS08720	COG1136	(ABC) transporter
H7R81_RS08735	COG2814	Major facilitator Superfamily
H7R81_RS08755	COG0672	)-iron permease
H7R81_RS08795	COG0659	secondary active sulfate transmembrane transporter activity
H7R81_RS08820	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H7R81_RS08820	COG0392	lysyltransferase activity
H7R81_RS08830	COG2205	protein histidine kinase activity
H7R81_RS08835	COG0745	RESPONSE REGULATOR receiver
H7R81_RS08840	COG3550	peptidyl-serine autophosphorylation
H7R81_RS08885	COG4584	PFAM Integrase catalytic
H7R81_RS08890	COG1484	DNA-dependent DNA replication
H7R81_RS08925	COG0675	Transposase, IS605 OrfB family
H7R81_RS08945	COG3039	Transposase
H7R81_RS08960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R81_RS08970	COG1111	helicase
H7R81_RS08970	COG1205	dead DEAH box helicase
H7R81_RS08975	COG0210	DNA helicase
H7R81_RS09065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H7R81_RS09070	COG1278	Cold shock
H7R81_RS09075	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H7R81_RS09080	COG0542	response to heat
H7R81_RS09085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H7R81_RS09090	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H7R81_RS09095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H7R81_RS09100	COG3134	Outer membrane lipoprotein
H7R81_RS09105	COG3706	GGDEF domain
H7R81_RS09110	COG0492	ferredoxin-NADP+ reductase activity
H7R81_RS09115	COG0686	Belongs to the AlaDH PNT family
H7R81_RS09125	COG0531	amino acid
H7R81_RS09125	COG1674	ftsk spoiiie
H7R81_RS09130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H7R81_RS09135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7R81_RS09140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H7R81_RS09150	COG1286	toxin biosynthetic process
H7R81_RS09155	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7R81_RS09165	COG0563	adenylate kinase activity
H7R81_RS09170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H7R81_RS09180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R81_RS09195	COG5001	Diguanylate cyclase
H7R81_RS09195	COG3300	MHYT domain
H7R81_RS09250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7R81_RS09255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H7R81_RS09260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R81_RS09265	COG0840	transmembrane signaling receptor activity
H7R81_RS09275	COG0513	Belongs to the DEAD box helicase family
H7R81_RS09280	COG0386	Belongs to the glutathione peroxidase family
H7R81_RS09290	COG1181	Belongs to the D-alanine--D-alanine ligase family
H7R81_RS09295	COG1570	exodeoxyribonuclease VII activity
H7R81_RS09300	COG1278	Cold shock
H7R81_RS09305	COG0516	GMP reductase activity
H7R81_RS09305	COG0517	IMP dehydrogenase activity
H7R81_RS09310	COG0519	Catalyzes the synthesis of GMP from XMP
H7R81_RS09310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H7R81_RS09330	COG1484	DNA-dependent DNA replication
H7R81_RS09360	COG1025	Belongs to the peptidase M16 family
H7R81_RS09365	COG2062	phosphohistidine phosphatase, SixA
H7R81_RS09375	COG0697	spore germination
H7R81_RS09390	COG0058	SHG alpha-glucan phosphorylase activity
H7R81_RS09395	COG0471	metal ion transport
H7R81_RS09400	COG3118	belongs to the thioredoxin family
H7R81_RS09410	COG1132	(ABC) transporter
H7R81_RS09415	COG1132	(ABC) transporter
H7R81_RS09425	COG2501	S4 domain
H7R81_RS09440	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7R81_RS09485	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H7R81_RS09490	COG1053	succinate dehydrogenase
H7R81_RS09500	COG0567	Dehydrogenase, E1 component
H7R81_RS09505	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R81_RS09510	COG0045	succinate-CoA ligase (ADP-forming) activity
H7R81_RS09555	COG3088	subunit of a heme lyase
H7R81_RS09555	COG4235	cytochrome complex assembly
H7R81_RS09565	COG1138	Cytochrome C-type biogenesis protein
H7R81_RS09570	COG3301	Polysulphide reductase, NrfD
H7R81_RS09575	COG0437	4 iron, 4 sulfur cluster binding
H7R81_RS09580	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H7R81_RS09600	COG0247	lactate metabolic process
H7R81_RS09605	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
H7R81_RS09610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H7R81_RS09615	COG3012	SEC-C Motif Domain Protein
H7R81_RS09620	COG0840	transmembrane signaling receptor activity
H7R81_RS09625	COG1940	carbohydrate kinase activity
H7R81_RS09625	COG1846	Transcriptional regulator
H7R81_RS09630	COG3148	PFAM DTW domain containing protein
H7R81_RS09640	COG0583	DNA-binding transcription factor activity
H7R81_RS09655	COG3593	DNA synthesis involved in DNA repair
H7R81_RS09720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R81_RS09725	COG1011	Hydrolase
H7R81_RS09740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R81_RS09745	COG2832	Protein of unknown function (DUF454)
H7R81_RS09750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7R81_RS09760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H7R81_RS09775	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H7R81_RS09785	COG3158	transport of potassium into the cell
H7R81_RS09815	COG1660	Displays ATPase and GTPase activities
H7R81_RS09880	COG1695	Transcriptional regulator
H7R81_RS09905	COG3173	Aminoglycoside phosphotransferase
H7R81_RS09950	COG3344	reverse transcriptase
H7R81_RS09975	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7R81_RS09985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R81_RS10030	COG1196	nuclear chromosome segregation
H7R81_RS10035	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R81_RS10045	COG3385	transposase activity
H7R81_RS10070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7R81_RS10075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R81_RS10080	COG3046	protein related to deoxyribodipyrimidine photolyase
H7R81_RS10090	COG3033	Beta-eliminating lyase
H7R81_RS10095	COG0295	cytidine deaminase activity
H7R81_RS10100	COG1346	cytolysis
H7R81_RS10105	COG1380	Effector of murein hydrolase LrgA
H7R81_RS10110	COG3345	alpha-galactosidase
H7R81_RS10120	COG2925	Exonuclease
H7R81_RS10220	COG2326	polyphosphate kinase activity
H7R81_RS10225	COG0641	radical SAM
H7R81_RS10255	COG2304	oxidoreductase activity
H7R81_RS10270	COG0714	Associated with various cellular activities
H7R81_RS10275	COG3119	arylsulfatase activity
H7R81_RS10280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R81_RS10285	COG0617	tRNA 3'-terminal CCA addition
H7R81_RS10285	COG0517	IMP dehydrogenase activity
H7R81_RS10285	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7R81_RS10290	COG1643	Atp-dependent helicase
H7R81_RS10300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H7R81_RS10315	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H7R81_RS10320	COG2067	long-chain fatty acid transport protein
H7R81_RS10325	COG2067	long-chain fatty acid transport protein
H7R81_RS10335	COG1595	DNA-templated transcription, initiation
H7R81_RS10345	COG2304	oxidoreductase activity
H7R81_RS10365	COG0714	Associated with various cellular activities
H7R81_RS10370	COG0183	Belongs to the thiolase family
H7R81_RS10375	COG1024	Enoyl-CoA hydratase
H7R81_RS10375	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R81_RS10380	COG2719	SpoVR family
H7R81_RS10385	COG2718	Belongs to the UPF0229 family
H7R81_RS10390	COG2766	serine protein kinase
H7R81_RS10395	COG0514	ATP-dependent DNA helicase (RecQ)
H7R81_RS10400	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H7R81_RS10410	COG0814	amino acid
H7R81_RS10415	COG0494	nUDIX hydrolase
H7R81_RS10430	COG2824	Alkylphosphonate utilization operon protein PhnA
H7R81_RS10445	COG3791	Glutathione-dependent formaldehyde-activating
H7R81_RS10460	COG2840	Smr protein MutS2
H7R81_RS10465	COG2890	protein-(glutamine-N5) methyltransferase activity
H7R81_RS10470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H7R81_RS10480	COG0513	Belongs to the DEAD box helicase family
H7R81_RS10485	COG3788	relative of glutathione S-transferase, MAPEG superfamily
H7R81_RS10490	COG0814	amino acid
H7R81_RS10495	COG1609	Transcriptional regulator
H7R81_RS10500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R81_RS10500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R81_RS10505	COG1105	Belongs to the carbohydrate kinase PfkB family
H7R81_RS10510	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H7R81_RS10510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R81_RS10510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R81_RS10515	COG3313	Fe-S protein
H7R81_RS10520	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H7R81_RS10525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R81_RS10530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R81_RS10535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7R81_RS10545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R81_RS10555	COG0366	Alpha amylase catalytic
H7R81_RS10575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H7R81_RS10580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H7R81_RS10585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H7R81_RS10590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H7R81_RS10595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H7R81_RS10600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R81_RS10600	COG0072	phenylalanine-tRNA ligase activity
H7R81_RS10605	COG0776	regulation of translation
H7R81_RS10610	COG2205	protein histidine kinase activity
H7R81_RS10610	COG0784	Response regulator, receiver
H7R81_RS10630	COG1609	Transcriptional regulator
H7R81_RS10635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R81_RS10640	COG1879	ABC-type sugar transport system periplasmic component
H7R81_RS10645	COG1172	Belongs to the binding-protein-dependent transport system permease family
H7R81_RS10650	COG1129	ABC transporter
H7R81_RS10655	COG1869	D-ribose catabolic process
H7R81_RS10660	COG0625	glutathione transferase activity
H7R81_RS10665	COG5654	RES domain protein
H7R81_RS10680	COG1177	transmembrane transport
H7R81_RS10705	COG0037	tRNA processing
H7R81_RS10710	COG0589	response to stress
H7R81_RS10715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7R81_RS10730	COG2217	Heavy metal translocating P-type atpase
H7R81_RS10740	COG2010	Cytochrome c
H7R81_RS10755	COG3278	Belongs to the heme-copper respiratory oxidase family
H7R81_RS10765	COG1956	GAF domain-containing protein
H7R81_RS10770	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H7R81_RS10780	COG0308	aminopeptidase N
H7R81_RS10790	COG2902	Dehydrogenase
H7R81_RS10795	COG0167	dihydroorotate dehydrogenase activity
H7R81_RS10805	COG0254	rRNA binding
H7R81_RS10810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7R81_RS10815	COG0116	Belongs to the methyltransferase superfamily
H7R81_RS10815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R81_RS10825	COG0488	(ABC) transporter
H7R81_RS10835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R81_RS10840	COG1067	ATP-dependent peptidase activity
H7R81_RS10865	COG3141	response to X-ray
H7R81_RS10870	COG0596	Alpha beta hydrolase
H7R81_RS10880	COG4644	lycopene metabolic process
H7R81_RS10890	COG0840	transmembrane signaling receptor activity
H7R81_RS10935	COG2079	MmgE PrpD family protein
H7R81_RS10940	COG0372	Belongs to the citrate synthase family
H7R81_RS10945	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H7R81_RS10955	COG2995	paraquat-inducible protein a
H7R81_RS10960	COG3008	intermembrane lipid transfer
H7R81_RS10965	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H7R81_RS10965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R81_RS10980	COG0084	hydrolase, TatD family'
H7R81_RS10985	COG0470	DNA polymerase III
H7R81_RS10990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H7R81_RS10995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7R81_RS11000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7R81_RS11010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7R81_RS11015	COG1028	Short-chain dehydrogenase reductase Sdr
H7R81_RS11025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R81_RS11030	COG0416	fatty acid biosynthetic process
H7R81_RS11035	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H7R81_RS11040	COG1399	metal-binding, possibly nucleic acid-binding protein
H7R81_RS11045	COG0424	maF-like protein
H7R81_RS11050	COG0583	DNA-binding transcription factor activity
H7R81_RS11070	COG0546	phosphoglycolate phosphatase activity
H7R81_RS11075	COG0564	pseudouridine synthase activity
H7R81_RS11080	COG1530	ribonuclease E activity
H7R81_RS11090	COG0306	phosphate transporter
H7R81_RS11095	COG0717	Belongs to the dCTP deaminase family
H7R81_RS11100	COG0572	uridine kinase
H7R81_RS11105	COG0489	protein tyrosine kinase activity
H7R81_RS11110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R81_RS11110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7R81_RS11120	COG1254	Belongs to the acylphosphatase family
H7R81_RS11125	COG0840	transmembrane signaling receptor activity
H7R81_RS11130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7R81_RS11145	COG0709	Synthesizes selenophosphate from selenide and ATP
H7R81_RS11150	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H7R81_RS11155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R81_RS11165	COG0318	PFAM AMP-dependent synthetase and ligase
H7R81_RS11170	COG2267	carboxylic ester hydrolase activity
H7R81_RS11180	COG1214	PFAM Peptidase M22, glycoprotease
H7R81_RS11185	COG1199	ATP-dependent helicase activity
H7R81_RS11195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H7R81_RS11200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H7R81_RS11205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H7R81_RS11210	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H7R81_RS11210	COG0131	Imidazoleglycerol-phosphate dehydratase
H7R81_RS11215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H7R81_RS11220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H7R81_RS11225	COG0107	imidazoleglycerol-phosphate synthase activity
H7R81_RS11240	COG2199	diguanylate cyclase activity
H7R81_RS11245	COG0318	PFAM AMP-dependent synthetase and ligase
H7R81_RS11250	COG1288	antiporter activity
H7R81_RS11260	COG3134	Outer membrane lipoprotein
H7R81_RS11265	COG2080	2 iron, 2 sulfur cluster binding
H7R81_RS11270	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7R81_RS11275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7R81_RS11280	COG2252	PERMEase
H7R81_RS11285	COG0402	S-adenosylhomocysteine deaminase activity
H7R81_RS11290	COG2233	PERMEase
H7R81_RS11295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H7R81_RS11295	COG2080	2 iron, 2 sulfur cluster binding
H7R81_RS11300	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H7R81_RS11305	COG0402	S-adenosylhomocysteine deaminase activity
H7R81_RS11310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R81_RS11310	COG0493	'glutamate synthase
H7R81_RS11315	COG2068	MobA-Related Protein
H7R81_RS11320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H7R81_RS11325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H7R81_RS11325	COG3608	succinylglutamate desuccinylase aspartoacylase
H7R81_RS11335	COG0697	spore germination
H7R81_RS11340	COG0549	Belongs to the carbamate kinase family
H7R81_RS11350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7R81_RS11355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7R81_RS11360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H7R81_RS11380	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R81_RS11390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H7R81_RS11395	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H7R81_RS11400	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H7R81_RS11410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H7R81_RS11415	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H7R81_RS11425	COG0205	6-phosphofructokinase activity
H7R81_RS11435	COG3123	guanosine phosphorylase activity
H7R81_RS11440	COG1760	l-serine dehydratase
H7R81_RS11445	COG1760	l-serine dehydratase
H7R81_RS11450	COG3100	YcgL domain-containing protein
H7R81_RS11455	COG0850	regulation of cytokinetic process
H7R81_RS11460	COG2894	cell division
H7R81_RS11465	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H7R81_RS11470	COG3099	Belongs to the UPF0263 family
H7R81_RS11475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R81_RS11515	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H7R81_RS11520	COG0697	spore germination
H7R81_RS11525	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H7R81_RS11530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R81_RS11545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R81_RS11550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R81_RS11555	COG0307	riboflavin synthase, alpha
H7R81_RS11595	COG3829	transcription factor binding
H7R81_RS11605	COG4681	YaeQ
H7R81_RS11620	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7R81_RS11625	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H7R81_RS11630	COG0586	Pfam SNARE associated Golgi protein
H7R81_RS11640	COG0556	nucleotide-excision repair
H7R81_RS11650	COG2985	domain, Protein
H7R81_RS11650	COG0569	domain protein
H7R81_RS11655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7R81_RS11660	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7R81_RS11660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7R81_RS11675	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R81_RS11690	COG1451	nucleotide metabolic process
H7R81_RS11705	COG0417	DNA replication proofreading
H7R81_RS11715	COG2203	Gaf domain
H7R81_RS11715	COG2199	diguanylate cyclase activity
H7R81_RS11730	COG1560	Kdo2-lipid A biosynthetic process
H7R81_RS11735	COG1560	Kdo2-lipid A biosynthetic process
H7R81_RS11745	COG0583	DNA-binding transcription factor activity
H7R81_RS11755	COG1484	DNA-dependent DNA replication
H7R81_RS11760	COG4584	PFAM Integrase catalytic
H7R81_RS11780	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R81_RS11785	COG0651	ATP synthesis coupled electron transport
H7R81_RS11790	COG0650	Formate hydrogenlyase subunit 4
H7R81_RS11795	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
H7R81_RS11795	COG3261	NADH dehydrogenase
H7R81_RS11800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R81_RS11805	COG3260	NADH ubiquinone oxidoreductase 20
H7R81_RS11815	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7R81_RS11825	COG1921	L-seryl-tRNASec selenium transferase activity
H7R81_RS11835	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H7R81_RS11840	COG0298	carbon dioxide binding
H7R81_RS11850	COG0309	Hydrogenase expression formation protein (HypE)
H7R81_RS11855	COG0375	protein maturation
H7R81_RS11860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
H7R81_RS11865	COG3842	ATPase activity
H7R81_RS11875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R81_RS11880	COG0601	transmembrane transport
H7R81_RS11890	COG1773	rubredoxin
H7R81_RS11895	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H7R81_RS11900	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H7R81_RS11905	COG5557	Pfam Polysulphide reductase, NrfD
H7R81_RS11910	COG0437	4 iron, 4 sulfur cluster binding
H7R81_RS11915	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H7R81_RS11930	COG3437	response regulator, receiver
H7R81_RS11935	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H7R81_RS11940	COG3706	GGDEF domain
H7R81_RS11940	COG4251	negative regulation of phosphorylation
H7R81_RS11940	COG5001	Diguanylate cyclase
H7R81_RS11940	COG2203	Gaf domain
H7R81_RS11960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7R81_RS11965	COG1993	acr, cog1993
H7R81_RS12000	COG1393	Belongs to the ArsC family
H7R81_RS12005	COG0798	PFAM Bile acid sodium symporter
H7R81_RS12020	COG0640	Transcriptional regulator
H7R81_RS12050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R81_RS12065	COG2003	Belongs to the UPF0758 family
H7R81_RS12095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7R81_RS12110	COG0582	viral genome integration into host DNA
H7R81_RS12120	COG0730	response to heat
H7R81_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
H7R81_RS12140	COG1024	Enoyl-CoA hydratase
H7R81_RS12145	COG1024	Enoyl-CoA hydratase
H7R81_RS12150	COG1960	acyl-CoA dehydrogenase activity
H7R81_RS12155	COG1960	acyl-CoA dehydrogenase activity
H7R81_RS12160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H7R81_RS12165	COG1024	Enoyl-CoA hydratase
H7R81_RS12195	COG1584	GPR1 FUN34 yaaH family protein
H7R81_RS12210	COG1115	amino acid carrier protein
H7R81_RS12215	COG1024	Enoyl-CoA hydratase
H7R81_RS12230	COG3162	membrane
H7R81_RS12235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R81_RS12440	COG0270	DNA (cytosine-5-)-methyltransferase activity
H7R81_RS12510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R81_RS12555	COG2974	May be involved in recombination
H7R81_RS12605	COG0582	viral genome integration into host DNA
H7R81_RS12610	COG0488	(ABC) transporter
H7R81_RS12615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7R81_RS12620	COG0776	regulation of translation
H7R81_RS12625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7R81_RS12630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H7R81_RS12635	COG0740	serine-type endopeptidase activity
H7R81_RS12640	COG0544	peptidyl-prolyl cis-trans isomerase activity
H7R81_RS12650	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H7R81_RS12655	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R81_RS12660	COG1136	(ABC) transporter
H7R81_RS12665	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7R81_RS12675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7R81_RS12680	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H7R81_RS12685	COG4166	transmembrane transport
H7R81_RS12690	COG2983	Belongs to the UPF0260 family
H7R81_RS12695	COG3039	Transposase
H7R81_RS12700	COG1882	Formate acetyltransferase
H7R81_RS12705	COG2116	formate transmembrane transporter activity
H7R81_RS12710	COG1944	ATP diphosphatase activity
H7R81_RS12715	COG2723	6-phospho-beta-galactosidase activity
H7R81_RS12720	COG0583	DNA-binding transcription factor activity
H7R81_RS12730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H7R81_RS12735	COG0583	DNA-binding transcription factor activity
H7R81_RS12740	COG0583	DNA-binding transcription factor activity
H7R81_RS12745	COG0583	DNA-binding transcription factor activity
H7R81_RS12750	COG2910	NAD(P)H-binding
H7R81_RS12765	COG1022	Amp-dependent synthetase and ligase
H7R81_RS12780	COG0861	Integral membrane protein TerC family
H7R81_RS12785	COG2885	chlorophyll binding
H7R81_RS12790	COG2199	diguanylate cyclase activity
H7R81_RS12810	COG2154	pterin-4-alpha-carbinolamine dehydratase
H7R81_RS12820	COG1012	belongs to the aldehyde dehydrogenase family
H7R81_RS12825	COG1177	transmembrane transport
H7R81_RS12830	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R81_RS12835	COG3842	ATPase activity
H7R81_RS12840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H7R81_RS12845	COG0583	DNA-binding transcription factor activity
H7R81_RS12850	COG3768	UPF0283 membrane protein
H7R81_RS12855	COG3106	COG3106 Predicted ATPase
H7R81_RS12870	COG1842	Phage shock protein A
H7R81_RS12875	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H7R81_RS12880	COG0747	negative chemotaxis
H7R81_RS12885	COG4168	peptide transport system, permease
H7R81_RS12895	COG4172	Belongs to the ABC transporter superfamily
H7R81_RS12900	COG4172	Belongs to the ABC transporter superfamily
H7R81_RS12905	COG0326	Molecular chaperone. Has ATPase activity
H7R81_RS12910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H7R81_RS12950	COG4974	Belongs to the 'phage' integrase family
H7R81_RS12975	COG1435	thymidine kinase activity
H7R81_RS12980	COG1757	Na H antiporter
H7R81_RS12985	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R81_RS12990	COG2096	Adenosyltransferase
H7R81_RS12995	COG3530	Putative quorum-sensing-regulated virulence factor
H7R81_RS13000	COG0602	queuosine metabolic process
H7R81_RS13005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H7R81_RS13020	COG0284	orotidine-5'-phosphate decarboxylase activity
H7R81_RS13025	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7R81_RS13035	COG0776	regulation of translation
H7R81_RS13040	COG0539	negative regulation of cytoplasmic translation
H7R81_RS13045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H7R81_RS13050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R81_RS13065	COG2814	Major facilitator Superfamily
H7R81_RS13080	COG0778	Nitroreductase
H7R81_RS13085	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H7R81_RS13090	COG3300	MHYT domain
H7R81_RS13090	COG5001	Diguanylate cyclase
H7R81_RS13105	COG0583	DNA-binding transcription factor activity
H7R81_RS13110	COG3437	response regulator, receiver
H7R81_RS13135	COG4989	oxidoreductase activity
H7R81_RS13140	COG0724	RNA recognition motif
H7R81_RS13150	COG1126	abc transporter atp-binding protein
H7R81_RS13155	COG0765	amino acid transport
H7R81_RS13160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R81_RS13165	COG0765	amino acid transport
H7R81_RS13170	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
H7R81_RS13180	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H7R81_RS13200	COG4974	Belongs to the 'phage' integrase family
H7R81_RS13240	COG1484	DNA-dependent DNA replication
H7R81_RS13245	COG4584	PFAM Integrase catalytic
H7R81_RS13265	COG2203	Gaf domain
H7R81_RS13265	COG2199	diguanylate cyclase activity
H7R81_RS13305	COG3706	GGDEF domain
H7R81_RS13320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7R81_RS13335	COG3012	SEC-C Motif Domain Protein
H7R81_RS13335	COG3318	Belongs to the UPF0149 family
H7R81_RS13355	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R81_RS13360	COG1360	Flagellar Motor Protein
H7R81_RS13365	COG4771	TonB-dependent receptor
H7R81_RS13370	COG1770	oligopeptidase
H7R81_RS13390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R81_RS13395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R81_RS13400	COG0649	NAD binding
H7R81_RS13400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R81_RS13415	COG1034	ATP synthesis coupled electron transport
H7R81_RS13420	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H7R81_RS13425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R81_RS13430	COG0839	Belongs to the complex I subunit 6 family
H7R81_RS13435	COG0713	ATP synthesis coupled electron transport
H7R81_RS13445	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7R81_RS13450	COG1007	ATP synthesis coupled electron transport
H7R81_RS13455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7R81_RS13455	COG0047	phosphoribosylformylglycinamidine synthase activity
H7R81_RS13460	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H7R81_RS13465	COG3385	transposase activity
H7R81_RS13470	COG1645	bacterial-type flagellum-dependent swarming motility
H7R81_RS13475	COG1160	GTP binding
H7R81_RS13480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H7R81_RS13485	COG2976	Protein conserved in bacteria
H7R81_RS13490	COG0124	histidyl-tRNA synthetase
H7R81_RS13495	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H7R81_RS13510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7R81_RS13515	COG0105	UTP biosynthetic process
H7R81_RS13530	COG0633	Ferredoxin
H7R81_RS13535	COG0443	Heat shock 70 kDa protein
H7R81_RS13540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H7R81_RS13550	COG0822	iron-sulfur transferase activity
H7R81_RS13555	COG1104	cysteine desulfurase activity
H7R81_RS13560	COG1959	2 iron, 2 sulfur cluster binding
H7R81_RS13570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R81_RS13570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H7R81_RS13575	COG0509	glycine decarboxylation via glycine cleavage system
H7R81_RS13580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H7R81_RS13590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R81_RS13595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7R81_RS13615	COG2814	Major facilitator Superfamily
H7R81_RS13620	COG0625	glutathione transferase activity
H7R81_RS13630	COG0483	inositol monophosphate 1-phosphatase activity
H7R81_RS13645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7R81_RS13665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7R81_RS13670	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H7R81_RS13675	COG2089	acid synthase
H7R81_RS13685	COG2030	dehydratase
H7R81_RS13700	COG4695	Portal protein
H7R81_RS14095	COG0270	DNA (cytosine-5-)-methyltransferase activity
H7R81_RS14175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R81_RS14205	COG2974	May be involved in recombination
H7R81_RS14285	COG0322	excinuclease ABC activity
H7R81_RS14290	COG2197	response regulator
H7R81_RS14295	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H7R81_RS14300	COG2835	tetraacyldisaccharide 4'-kinase activity
H7R81_RS14305	COG1663	tetraacyldisaccharide 4'-kinase activity
H7R81_RS14315	COG0658	competence protein
H7R81_RS14315	COG2333	competence protein COMEC
H7R81_RS14330	COG1448	Aminotransferase
H7R81_RS14340	COG0583	DNA-binding transcription factor activity
H7R81_RS14345	COG3085	chromosome segregation
H7R81_RS14350	COG4574	serine-type endopeptidase inhibitor activity
H7R81_RS14355	COG0584	glycerophosphoryl diester phosphodiesterase
H7R81_RS14365	COG1349	DNA-binding transcription factor activity
H7R81_RS14370	COG2271	Major facilitator Superfamily
H7R81_RS14375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R81_RS14380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H7R81_RS14385	COG0583	DNA-binding transcription factor activity
H7R81_RS14405	COG0656	L-ascorbic acid biosynthetic process
H7R81_RS14415	COG2814	Major facilitator Superfamily
H7R81_RS14430	COG3220	belongs to the UPF0276 family
H7R81_RS14450	COG1294	oxidase, subunit
H7R81_RS14460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R81_RS14465	COG2979	Protein of unknown function (DUF533)
H7R81_RS14480	COG0583	DNA-binding transcription factor activity
H7R81_RS14490	COG2807	transmembrane transport
H7R81_RS14495	COG1187	pseudouridine synthase activity
H7R81_RS14500	COG0346	lactoylglutathione lyase activity
H7R81_RS14510	COG1061	Type III restriction enzyme res subunit
H7R81_RS14515	COG4657	Part of a membrane complex involved in electron transport
H7R81_RS14520	COG2878	Part of a membrane complex involved in electron transport
H7R81_RS14530	COG4658	electron transport chain
H7R81_RS14535	COG4659	FMN binding
H7R81_RS14540	COG4660	Part of a membrane complex involved in electron transport
H7R81_RS14545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7R81_RS14550	COG0346	lactoylglutathione lyase activity
H7R81_RS14585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H7R81_RS14590	COG0505	Belongs to the CarA family
H7R81_RS14600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H7R81_RS14610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7R81_RS14615	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H7R81_RS14620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H7R81_RS14625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7R81_RS14630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7R81_RS14635	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H7R81_RS14665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H7R81_RS14670	COG3385	transposase activity
H7R81_RS14675	COG0861	Integral membrane protein TerC family
H7R81_RS14690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R81_RS14695	COG0601	transmembrane transport
H7R81_RS14705	COG2095	MarC family integral membrane protein
H7R81_RS14710	COG1454	alcohol dehydrogenase
H7R81_RS14710	COG1012	belongs to the aldehyde dehydrogenase family
H7R81_RS14715	COG0217	transcriptional regulatory protein
H7R81_RS14720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H7R81_RS14730	COG1801	Protein of unknown function DUF72
H7R81_RS14735	COG4106	trans-aconitate 2-methyltransferase activity
H7R81_RS14740	COG0500	methyltransferase
H7R81_RS14760	COG0450	alkyl hydroperoxide reductase
H7R81_RS14765	COG0583	DNA-binding transcription factor activity
H7R81_RS14770	COG0791	NLP P60 protein
H7R81_RS14780	COG0583	DNA-binding transcription factor activity
H7R81_RS14785	COG2610	gluconate transmembrane transporter activity
H7R81_RS14790	COG3048	D-serine ammonia-lyase activity
H7R81_RS14800	COG0538	isocitrate dehydrogenase activity
H7R81_RS14805	COG2207	Transcriptional regulator
H7R81_RS14815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R81_RS14820	COG0659	secondary active sulfate transmembrane transporter activity
H7R81_RS14825	COG0589	response to stress
H7R81_RS14840	COG3152	Membrane
H7R81_RS14875	COG1309	transcriptional regulator
H7R81_RS14885	COG1454	alcohol dehydrogenase
H7R81_RS14905	COG0534	Mate efflux family protein
H7R81_RS14915	COG2841	Protein conserved in bacteria
H7R81_RS14925	COG3300	MHYT domain
H7R81_RS14925	COG5001	Diguanylate cyclase
H7R81_RS14930	COG3132	Protein of unknown function, DUF480
H7R81_RS14965	COG0708	Exodeoxyribonuclease III
H7R81_RS14990	COG1122	ATPase activity
H7R81_RS14995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R81_RS15025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R81_RS15030	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R81_RS15040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R81_RS15045	COG1120	ATPase activity
H7R81_RS15050	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R81_RS15055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7R81_RS15060	COG4771	TonB-dependent receptor
H7R81_RS15065	COG2375	cellular response to nickel ion
H7R81_RS15070	COG0784	Response regulator, receiver
H7R81_RS15070	COG3437	response regulator, receiver
H7R81_RS15080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7R81_RS15085	COG0328	RNA-DNA hybrid ribonuclease activity
H7R81_RS15090	COG2226	methyltransferase
H7R81_RS15095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7R81_RS15100	COG0741	lytic transglycosylase activity
H7R81_RS15100	COG1388	LysM domain
H7R81_RS15130	COG1376	ErfK ybiS ycfS ynhG family protein
H7R81_RS15130	COG1388	LysM domain
H7R81_RS15140	COG0471	metal ion transport
H7R81_RS15150	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H7R81_RS15155	COG0791	NLP P60 protein
H7R81_RS15175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H7R81_RS15180	COG0788	formyltetrahydrofolate deformylase activity
H7R81_RS15190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R81_RS15205	COG1196	nuclear chromosome segregation
H7R81_RS15205	COG0741	lytic transglycosylase activity
H7R81_RS15205	COG0739	heme binding
H7R81_RS15210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7R81_RS15220	COG0436	Aminotransferase
H7R81_RS15225	COG1288	antiporter activity
H7R81_RS15230	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H7R81_RS15235	COG1879	ABC-type sugar transport system periplasmic component
H7R81_RS15250	COG2964	Protein conserved in bacteria
H7R81_RS15255	COG3681	Belongs to the UPF0597 family
H7R81_RS15260	COG0251	oxidation-reduction process
H7R81_RS15265	COG0814	amino acid
H7R81_RS15285	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H7R81_RS15295	COG1166	arginine decarboxylase activity
H7R81_RS15300	COG2195	Cleaves the N-terminal amino acid of tripeptides
H7R81_RS15315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H7R81_RS15325	COG2353	YceI-like domain
H7R81_RS15330	COG0583	DNA-binding transcription factor activity
H7R81_RS15340	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H7R81_RS15345	COG0840	transmembrane signaling receptor activity
H7R81_RS15350	COG0302	gtp cyclohydrolase
H7R81_RS15355	COG0303	'Molybdopterin
H7R81_RS15360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7R81_RS15365	COG3385	transposase activity
H7R81_RS15370	COG2267	carboxylic ester hydrolase activity
H7R81_RS15375	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H7R81_RS15395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H7R81_RS15400	COG0315	cyclic pyranopterin monophosphate synthase activity
H7R81_RS15405	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7R81_RS15410	COG3005	denitrification pathway
H7R81_RS15420	COG0348	domain, Protein
H7R81_RS15425	COG0437	4 iron, 4 sulfur cluster binding
H7R81_RS15430	COG0243	molybdopterin cofactor binding
H7R81_RS15440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R81_RS15445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7R81_RS15450	COG3850	Histidine kinase
H7R81_RS15455	COG2197	response regulator
H7R81_RS15485	COG0121	glutamine amidotransferase
H7R81_RS15490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R81_RS15495	COG1960	acyl-CoA dehydrogenase activity
H7R81_RS15500	COG1473	amidohydrolase
H7R81_RS15505	COG2914	Belongs to the UPF0125 (RnfH) family
H7R81_RS15510	COG2867	negative regulation of translational initiation
H7R81_RS15515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7R81_RS15525	COG0784	Response regulator, receiver
H7R81_RS15525	COG2205	protein histidine kinase activity
H7R81_RS15535	COG3383	formate dehydrogenase (NAD+) activity
H7R81_RS15610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H7R81_RS15620	COG1960	acyl-CoA dehydrogenase activity
H7R81_RS15625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7R81_RS15635	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H7R81_RS15640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7R81_RS15645	COG1263	PTS System
H7R81_RS15645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R81_RS15650	COG1609	Transcriptional regulator
H7R81_RS15685	COG0737	Belongs to the 5'-nucleotidase family
H7R81_RS15690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R81_RS15690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R81_RS15690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R81_RS15710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7R81_RS15720	COG1187	pseudouridine synthase activity
H7R81_RS15725	COG1051	belongs to the nudix hydrolase family
H7R81_RS15730	COG0482	sulfurtransferase activity
H7R81_RS15735	COG2915	High frequency lysogenization protein hflD homolog
H7R81_RS15740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7R81_RS15745	COG2850	peptidyl-arginine hydroxylation
H7R81_RS15765	COG0625	glutathione transferase activity
H7R81_RS15770	COG0259	pyridoxamine-phosphate oxidase activity
H7R81_RS15775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7R81_RS15775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R81_RS15780	COG0251	oxidation-reduction process
H7R81_RS15785	COG1882	Formate acetyltransferase
H7R81_RS15790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H7R81_RS15805	COG1484	DNA-dependent DNA replication
H7R81_RS15810	COG4584	PFAM Integrase catalytic
H7R81_RS15820	COG3385	transposase activity
H7R81_RS15825	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7R81_RS15835	COG2853	Lipoprotein
H7R81_RS15845	COG3088	subunit of a heme lyase
H7R81_RS15845	COG4235	cytochrome complex assembly
H7R81_RS15850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R81_RS15855	COG1138	Cytochrome C-type biogenesis protein
H7R81_RS15860	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H7R81_RS15865	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R81_RS15870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R81_RS15875	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7R81_RS15890	COG0835	chemotaxis
H7R81_RS15900	COG1192	Involved in chromosome partitioning
H7R81_RS15905	COG1360	Flagellar Motor Protein
H7R81_RS15910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R81_RS15915	COG2201	protein-glutamate methylesterase activity
H7R81_RS15920	COG0643	Histidine kinase
H7R81_RS15920	COG0784	Response regulator, receiver
H7R81_RS15920	COG2198	Histidine kinase
H7R81_RS15925	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H7R81_RS15950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H7R81_RS15960	COG1684	flagellar biosynthetic protein fliR
H7R81_RS16015	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H7R81_RS16025	COG1677	Flagellar hook-basal body complex protein FliE
H7R81_RS16040	COG0469	pyruvate kinase activity
H7R81_RS16045	COG1737	Transcriptional regulator
H7R81_RS16050	COG0837	glucose binding
H7R81_RS16080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7R81_RS16090	COG0281	malic enzyme
H7R81_RS16110	COG0437	4 iron, 4 sulfur cluster binding
H7R81_RS16115	COG3383	formate dehydrogenase (NAD+) activity
H7R81_RS16115	COG3383	formate dehydrogenase (NAD+) activity
H7R81_RS16150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H7R81_RS16160	COG3852	Histidine kinase
H7R81_RS16175	COG4662	Binding-protein-dependent transport system inner membrane component
H7R81_RS16185	COG0746	molybdenum cofactor guanylyltransferase activity
H7R81_RS16190	COG0303	'Molybdopterin
H7R81_RS16195	COG1289	transmembrane transporter activity
H7R81_RS16235	COG2205	protein histidine kinase activity
H7R81_RS16235	COG0784	Response regulator, receiver
H7R81_RS16250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7R81_RS16255	COG0444	Belongs to the ABC transporter superfamily
H7R81_RS16260	COG4608	Belongs to the ABC transporter superfamily
H7R81_RS16270	COG2971	BadF BadG BcrA BcrD
H7R81_RS16295	COG3724	N-succinylarginine dihydrolase activity
H7R81_RS16325	COG2197	response regulator
H7R81_RS16335	COG3188	usher protein
H7R81_RS16350	COG2200	EAL domain
H7R81_RS16350	COG2199	diguanylate cyclase activity
H7R81_RS16350	COG2203	Gaf domain
H7R81_RS16355	COG0826	peptidase U32
H7R81_RS16360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7R81_RS16375	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H7R81_RS16380	COG3706	GGDEF domain
H7R81_RS16385	COG2211	Major facilitator Superfamily
H7R81_RS16390	COG0616	signal peptide processing
H7R81_RS16395	COG1028	Short-chain dehydrogenase reductase Sdr
H7R81_RS16400	COG0583	DNA-binding transcription factor activity
H7R81_RS16410	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H7R81_RS16425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H7R81_RS16430	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H7R81_RS16430	COG3408	Glycogen debranching enzyme
H7R81_RS16440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H7R81_RS16460	COG1115	amino acid carrier protein
H7R81_RS16465	COG0019	diaminopimelate decarboxylase activity
H7R81_RS16475	COG0678	peroxiredoxin activity
H7R81_RS16500	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R81_RS16505	COG3142	Participates in the control of copper homeostasis
H7R81_RS16530	COG5002	protein histidine kinase activity
H7R81_RS16535	COG0745	RESPONSE REGULATOR receiver
H7R81_RS16540	COG0346	lactoylglutathione lyase activity
H7R81_RS16550	COG0697	spore germination
H7R81_RS16560	COG3290	protein histidine kinase activity
H7R81_RS16565	COG0281	malic enzyme
H7R81_RS16575	COG1846	Transcriptional regulator
H7R81_RS16610	COG0602	queuosine metabolic process
H7R81_RS16625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7R81_RS16630	COG3115	cell septum assembly
H7R81_RS16635	COG1196	nuclear chromosome segregation
H7R81_RS16645	COG2860	membrane
H7R81_RS16655	COG3108	Peptidase M15
H7R81_RS16660	COG2989	Protein conserved in bacteria
H7R81_RS16675	COG0463	Glycosyl transferase, family 2
H7R81_RS16690	COG0366	Alpha amylase catalytic
H7R81_RS16725	COG2203	Gaf domain
H7R81_RS16725	COG2199	diguanylate cyclase activity
H7R81_RS16735	COG3590	peptidase
H7R81_RS16745	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H7R81_RS16750	COG1982	Orn Lys Arg decarboxylase major
H7R81_RS16755	COG0531	amino acid
H7R81_RS16760	COG3710	Transcriptional regulator
H7R81_RS16765	COG0488	(ABC) transporter
H7R81_RS16775	COG0531	amino acid
H7R81_RS16790	COG0814	amino acid
H7R81_RS16805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R81_RS16810	COG0739	heme binding
H7R81_RS16815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H7R81_RS16820	COG0251	oxidation-reduction process
H7R81_RS16830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H7R81_RS16840	COG3091	SprT-like family
H7R81_RS16850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7R81_RS16855	COG0189	ligase activity
H7R81_RS16865	COG1678	Uncharacterized ACR, COG1678
H7R81_RS16870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H7R81_RS16875	COG3104	oligopeptide transport
H7R81_RS16910	COG0714	Associated with various cellular activities
H7R81_RS16925	COG1115	amino acid carrier protein
H7R81_RS16930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7R81_RS16940	COG0825	malonyl-CoA metabolic process
H7R81_RS16950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H7R81_RS16955	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R81_RS16960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R81_RS16965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H7R81_RS16970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H7R81_RS16985	COG0750	zinc metalloprotease
H7R81_RS16990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H7R81_RS16995	COG0575	Belongs to the CDS family
H7R81_RS17000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H7R81_RS17005	COG0233	cytoplasmic translational termination
H7R81_RS17010	COG0528	UMP kinase activity
H7R81_RS17015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H7R81_RS17020	COG0052	Belongs to the universal ribosomal protein uS2 family
H7R81_RS17025	COG0024	Methionine aminopeptidase
H7R81_RS17030	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H7R81_RS17035	COG2171	N-acyltransferase activity
H7R81_RS17045	COG3385	transposase activity
H7R81_RS17050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R81_RS17050	COG1263	PTS System
H7R81_RS17070	COG0564	pseudouridine synthase activity
H7R81_RS17075	COG3098	single-species biofilm formation
H7R81_RS17100	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H7R81_RS17110	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R81_RS17110	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H7R81_RS17125	COG1611	Belongs to the LOG family
H7R81_RS17130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7R81_RS17135	COG0473	3-isopropylmalate dehydrogenase activity
H7R81_RS17145	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H7R81_RS17150	COG2363	Small membrane protein
H7R81_RS17160	COG0583	DNA-binding transcription factor activity
H7R81_RS17165	COG0840	transmembrane signaling receptor activity
H7R81_RS17170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7R81_RS17185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H7R81_RS17190	COG1666	GTP binding
H7R81_RS17195	COG3248	Nucleoside-binding outer membrane protein
H7R81_RS17200	COG2211	Major facilitator Superfamily
H7R81_RS17205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7R81_RS17215	COG2813	Specifically methylates the guanine in position
H7R81_RS17220	COG0271	Belongs to the BolA IbaG family
H7R81_RS17225	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R81_RS17230	COG1805	sodium ion transport
H7R81_RS17235	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R81_RS17240	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R81_RS17245	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H7R81_RS17250	COG2871	sodium ion transport
H7R81_RS17255	COG1477	protein flavinylation
H7R81_RS17285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H7R81_RS17300	COG0300	oxidoreductase activity
H7R81_RS17310	COG0415	Belongs to the DNA photolyase family
H7R81_RS17315	COG0789	Transcriptional regulator
H7R81_RS17320	COG3272	Protein of unknown function (DUF1722)
H7R81_RS17350	COG0077	Prephenate dehydratase
H7R81_RS17350	COG1605	Chorismate mutase
H7R81_RS17390	COG0300	oxidoreductase activity
H7R81_RS17415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H7R81_RS17455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H7R81_RS17460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R81_RS17470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7R81_RS17475	COG0826	peptidase U32
H7R81_RS17480	COG1280	lysine exporter protein (LysE YggA)
H7R81_RS17490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H7R81_RS17500	COG0745	RESPONSE REGULATOR receiver
H7R81_RS17510	COG2198	Histidine kinase
H7R81_RS17510	COG0643	Histidine kinase
H7R81_RS17520	COG0835	chemotaxis
H7R81_RS17525	COG0840	transmembrane signaling receptor activity
H7R81_RS17535	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H7R81_RS17540	COG2201	protein-glutamate methylesterase activity
H7R81_RS17545	COG1185	polyribonucleotide nucleotidyltransferase activity
H7R81_RS17550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H7R81_RS17555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H7R81_RS17560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H7R81_RS17565	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H7R81_RS17570	COG0195	Participates in both transcription termination and antitermination
H7R81_RS17575	COG0779	Required for maturation of 30S ribosomal subunits
H7R81_RS17590	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7R81_RS17595	COG0149	triose-phosphate isomerase activity
H7R81_RS17600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7R81_RS17605	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H7R81_RS17615	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H7R81_RS17620	COG1534	Rna-binding protein
H7R81_RS17635	COG1360	Flagellar Motor Protein
H7R81_RS17640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H7R81_RS17645	COG1722	exodeoxyribonuclease VII activity
H7R81_RS17650	COG0142	geranyltranstransferase activity
H7R81_RS17655	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H7R81_RS17660	COG3385	transposase activity
H7R81_RS17665	COG0737	Belongs to the 5'-nucleotidase family
H7R81_RS17685	COG2204	response regulator
H7R81_RS17690	COG0545	Peptidyl-prolyl cis-trans isomerase
H7R81_RS17700	COG2900	Belongs to the SlyX family
H7R81_RS17710	COG0601	transmembrane transport
H7R81_RS17725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7R81_RS17730	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H7R81_RS17735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7R81_RS17740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H7R81_RS17755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R81_RS17755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7R81_RS17760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7R81_RS17765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H7R81_RS17780	COG2205	protein histidine kinase activity
H7R81_RS17780	COG2198	Histidine kinase
H7R81_RS17780	COG0784	Response regulator, receiver
H7R81_RS17785	COG1879	ABC-type sugar transport system periplasmic component
H7R81_RS17795	COG0745	RESPONSE REGULATOR receiver
H7R81_RS17800	COG3005	denitrification pathway
H7R81_RS17810	COG3381	protein complex oligomerization
H7R81_RS17840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R81_RS17845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H7R81_RS17850	COG0511	ligase activity, forming carbon-carbon bonds
H7R81_RS17855	COG0439	Biotin carboxylase
H7R81_RS17860	COG3924	membrane
H7R81_RS17865	COG4145	pantothenate transmembrane transporter activity
H7R81_RS17870	COG1263	PTS System
H7R81_RS17870	COG2190	(PTS) system
H7R81_RS17870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R81_RS17875	COG0583	DNA-binding transcription factor activity
H7R81_RS17880	COG0604	alcohol dehydrogenase
H7R81_RS17885	COG2264	protein methyltransferase activity
H7R81_RS17890	COG0110	maltose O-acetyltransferase activity
H7R81_RS17895	COG0778	Nitroreductase
H7R81_RS17900	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7R81_RS17900	COG1902	pentaerythritol trinitrate reductase activity
H7R81_RS17905	COG0616	signal peptide processing
H7R81_RS17925	COG0848	biopolymer transport protein
H7R81_RS17930	COG0811	peptide transport
H7R81_RS17935	COG0811	peptide transport
H7R81_RS17950	COG4174	ABC transporter (Permease)
H7R81_RS17955	COG4239	(ABC) transporter, permease
H7R81_RS17965	COG0444	Belongs to the ABC transporter superfamily
H7R81_RS17970	COG4608	Belongs to the ABC transporter superfamily
H7R81_RS17975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H7R81_RS17995	COG2188	Transcriptional regulator
H7R81_RS18015	COG2816	NAD+ diphosphatase activity
H7R81_RS18060	COG3385	transposase activity
H7R81_RS18065	COG1858	cytochrome C peroxidase
H7R81_RS18070	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
H7R81_RS18080	COG2203	Gaf domain
H7R81_RS18080	COG2199	diguanylate cyclase activity
H7R81_RS18085	COG0513	Belongs to the DEAD box helicase family
H7R81_RS18105	COG0154	amidase activity
H7R81_RS18110	COG2957	Belongs to the agmatine deiminase family
H7R81_RS18125	COG1902	pentaerythritol trinitrate reductase activity
H7R81_RS18140	COG1238	metal cluster binding
H7R81_RS18145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7R81_RS18150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H7R81_RS18155	COG0585	pseudouridine synthase activity
H7R81_RS18165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H7R81_RS18170	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H7R81_RS18175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7R81_RS18190	COG1376	ErfK ybiS ycfS ynhG family protein
H7R81_RS18195	COG0668	transmembrane transport
H7R81_RS18205	COG2731	YhcH YjgK YiaL family protein
H7R81_RS18215	COG1794	racemase activity, acting on amino acids and derivatives
H7R81_RS18230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7R81_RS18250	COG0488	(ABC) transporter
H7R81_RS18260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7R81_RS18300	COG0148	phosphopyruvate hydratase activity
H7R81_RS18305	COG0504	CTP synthase activity
H7R81_RS18310	COG3956	TIGRFAM MazG family protein
H7R81_RS18315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7R81_RS18320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R81_RS18330	COG4807	Protein conserved in bacteria
H7R81_RS18335	COG3023	N-Acetylmuramoyl-L-alanine amidase
H7R81_RS18340	COG0783	Belongs to the Dps family
H7R81_RS18345	COG1151	hydroxylamine reductase activity
H7R81_RS18350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H7R81_RS18355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R81_RS18360	COG0671	phosphoesterase, PA-phosphatase related
H7R81_RS18365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R81_RS18370	COG0163	prenyltransferase activity
H7R81_RS18385	COG1131	(ABC) transporter
H7R81_RS18390	COG0842	Transport permease protein
H7R81_RS18395	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
H7R81_RS18400	COG1924	4 iron, 4 sulfur cluster binding
H7R81_RS18415	COG1129	ABC transporter
H7R81_RS18425	COG1486	melibiose metabolic process
H7R81_RS18440	COG1823	symporter activity
H7R81_RS18450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H7R81_RS18455	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H7R81_RS18460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H7R81_RS18465	COG0617	tRNA 3'-terminal CCA addition
H7R81_RS18470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H7R81_RS18475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7R81_RS18480	COG1489	DNA binding
H7R81_RS18490	COG1643	Atp-dependent helicase
H7R81_RS18495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7R81_RS18500	COG0346	lactoylglutathione lyase activity
H7R81_RS18505	COG2076	Multidrug Resistance protein
H7R81_RS18510	COG2076	Multidrug Resistance protein
H7R81_RS18515	COG0583	DNA-binding transcription factor activity
H7R81_RS18520	COG3437	response regulator, receiver
H7R81_RS18520	COG0784	Response regulator, receiver
H7R81_RS18525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H7R81_RS18540	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H7R81_RS18555	COG1136	(ABC) transporter
H7R81_RS18580	COG0529	Catalyzes the synthesis of activated sulfate
H7R81_RS18585	COG0471	metal ion transport
H7R81_RS18585	COG3273	potassium ion transport
H7R81_RS18590	COG2895	sulfate adenylyltransferase (ATP) activity
H7R81_RS18595	COG0175	sulfate reduction
H7R81_RS18600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R81_RS18600	COG1648	precorrin-2 dehydrogenase activity
H7R81_RS18605	COG0330	HflC and HflK could
H7R81_RS18610	COG1585	Membrane protein implicated in regulation of membrane protease activity
H7R81_RS18615	COG0840	transmembrane signaling receptor activity
H7R81_RS18620	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H7R81_RS18625	COG0676	glucose-6-phosphate 1-epimerase activity
H7R81_RS18630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7R81_RS18635	COG1640	4-alpha-glucanotransferase
H7R81_RS18640	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7R81_RS18680	COG0561	phosphatase activity
H7R81_RS18695	COG0733	neurotransmitter:sodium symporter activity
H7R81_RS18705	COG0733	neurotransmitter:sodium symporter activity
H7R81_RS18770	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H7R81_RS18775	COG2885	chlorophyll binding
H7R81_RS18780	COG0823	Involved in the tonB-independent uptake of proteins
H7R81_RS18795	COG0811	peptide transport
H7R81_RS18800	COG0824	Thioesterase
H7R81_RS18805	COG3790	cyd operon protein YbgE
H7R81_RS18810	COG4890	Cyd operon protein YbgT
H7R81_RS18815	COG1294	oxidase, subunit
H7R81_RS18825	COG2255	four-way junction helicase activity
H7R81_RS18830	COG0632	four-way junction helicase activity
H7R81_RS18835	COG0840	transmembrane signaling receptor activity
H7R81_RS18850	COG2771	luxR family
H7R81_RS18855	COG3916	Acyl-homoserine-lactone synthase
H7R81_RS18865	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H7R81_RS18870	COG2203	Gaf domain
H7R81_RS18870	COG3706	GGDEF domain
H7R81_RS18870	COG4251	negative regulation of phosphorylation
H7R81_RS18870	COG5001	Diguanylate cyclase
H7R81_RS18880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7R81_RS18890	COG2995	paraquat-inducible protein a
H7R81_RS18895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R81_RS18895	COG3008	intermembrane lipid transfer
H7R81_RS18905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R81_RS18910	COG0442	prolyl-tRNA aminoacylation
H7R81_RS18915	COG4221	oxidoreductase activity
H7R81_RS18930	COG1024	Enoyl-CoA hydratase
H7R81_RS18945	COG4166	transmembrane transport
H7R81_RS18955	COG0840	transmembrane signaling receptor activity
H7R81_RS18960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7R81_RS18965	COG0735	belongs to the Fur family
H7R81_RS18990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7R81_RS18995	COG0513	Belongs to the DEAD box helicase family
H7R81_RS19000	COG2153	protein acetylation
H7R81_RS19010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7R81_RS19015	COG0557	exoribonuclease II activity
H7R81_RS19020	COG3706	GGDEF domain
H7R81_RS19025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H7R81_RS19025	COG2885	chlorophyll binding
H7R81_RS19035	COG3385	transposase activity
H7R81_RS19040	COG3111	PFAM Bacterial OB fold (BOF) protein
H7R81_RS19050	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H7R81_RS19055	COG1194	a g-specific adenine glycosylase
H7R81_RS19060	COG0617	tRNA 3'-terminal CCA addition
H7R81_RS19080	COG3068	Protein conserved in bacteria
H7R81_RS19090	COG0739	heme binding
H7R81_RS19110	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H7R81_RS19115	COG1121	(ABC) transporter
H7R81_RS19120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7R81_RS19125	COG0583	DNA-binding transcription factor activity
H7R81_RS19130	COG0697	spore germination
H7R81_RS19135	COG1573	uracil-dna glycosylase
H7R81_RS19150	COG2827	Endonuclease containing a URI domain
H7R81_RS19165	COG1842	Phage shock protein A
H7R81_RS19170	COG0204	Acyl-transferase
H7R81_RS19190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7R81_RS19195	COG0484	heat shock protein binding
H7R81_RS19215	COG4221	oxidoreductase activity
H7R81_RS19250	COG3150	esterase
H7R81_RS19260	COG3151	Protein conserved in bacteria
H7R81_RS19265	COG0494	nUDIX hydrolase
H7R81_RS19270	COG1538	Outer membrane efflux protein
H7R81_RS19275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7R81_RS19275	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7R81_RS19280	COG1560	Kdo2-lipid A biosynthetic process
H7R81_RS19285	COG2213	PTS system mannitol-specific
H7R81_RS19285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R81_RS19290	COG0246	Mannitol dehydrogenase
H7R81_RS19295	COG3722	fumarate hydratase activity
H7R81_RS19325	COG1671	Belongs to the UPF0178 family
H7R81_RS19330	COG1988	membrane-bound metal-dependent
H7R81_RS19335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7R81_RS19340	COG0513	Belongs to the DEAD box helicase family
H7R81_RS19360	COG1575	Belongs to the MenA family. Type 1 subfamily
H7R81_RS19365	COG1169	isochorismate synthase
H7R81_RS19370	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H7R81_RS19385	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H7R81_RS19390	COG1441	menaquinone biosynthetic process
H7R81_RS19395	COG0318	PFAM AMP-dependent synthetase and ligase
H7R81_RS19400	COG3291	Pkd domain containing protein
H7R81_RS19405	COG2949	membrane
H7R81_RS19410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7R81_RS19420	COG0784	Response regulator, receiver
H7R81_RS19420	COG0835	chemotaxis
H7R81_RS19430	COG1444	tRNA N-acetyltransferase activity
H7R81_RS19450	COG1803	Methylglyoxal synthase
H7R81_RS19455	COG1979	alcohol dehydrogenase
H7R81_RS19475	COG4221	oxidoreductase activity
H7R81_RS19515	COG1368	sulfuric ester hydrolase activity
H7R81_RS19520	COG1522	sequence-specific DNA binding
H7R81_RS19530	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H7R81_RS19540	COG1546	Belongs to the CinA family
H7R81_RS19540	COG1058	Belongs to the CinA family
H7R81_RS19550	COG0561	phosphatase activity
H7R81_RS19560	COG2926	Belongs to the UPF0265 family
H7R81_RS19595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7R81_RS19600	COG0564	pseudouridine synthase activity
H7R81_RS19610	COG0110	maltose O-acetyltransferase activity
H7R81_RS19615	COG0366	Alpha amylase catalytic
H7R81_RS19620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7R81_RS19620	COG1263	PTS System
H7R81_RS19640	COG0252	asparaginase activity
H7R81_RS19645	COG1253	flavin adenine dinucleotide binding
H7R81_RS19650	COG0586	Pfam SNARE associated Golgi protein
H7R81_RS19655	COG1686	Belongs to the peptidase S11 family
H7R81_RS19690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H7R81_RS19700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H7R81_RS19710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H7R81_RS19715	COG1546	Belongs to the CinA family
H7R81_RS19720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H7R81_RS19725	COG4667	esterase of the alpha-beta hydrolase superfamily
H7R81_RS19735	COG1346	cytolysis
H7R81_RS19740	COG1380	Effector of murein hydrolase LrgA
H7R81_RS19745	COG0583	DNA-binding transcription factor activity
H7R81_RS19765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7R81_RS19775	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H7R81_RS19785	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H7R81_RS19790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H7R81_RS19800	COG0137	argininosuccinate synthase activity
H7R81_RS19805	COG0165	Argininosuccinate lyase
H7R81_RS19815	COG2226	methyltransferase
H7R81_RS19840	COG3314	Sporulation integral membrane protein YlbJ
H7R81_RS19865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H7R81_RS19870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H7R81_RS19885	COG0477	Major facilitator Superfamily
H7R81_RS19890	COG0523	cobalamin synthesis protein
H7R81_RS19900	COG2200	EAL domain
H7R81_RS19905	COG1049	propionate catabolic process, 2-methylcitrate cycle
H7R81_RS19910	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7R81_RS19915	COG0840	transmembrane signaling receptor activity
H7R81_RS19925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7R81_RS19930	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7R81_RS19935	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7R81_RS19940	COG2186	Transcriptional regulator
H7R81_RS19965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7R81_RS19970	COG1459	type II secretion system
H7R81_RS19985	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H7R81_RS19990	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H7R81_RS19995	COG0494	nUDIX hydrolase
H7R81_RS20000	COG0653	protein targeting
H7R81_RS20010	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H7R81_RS20015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H7R81_RS20020	COG0849	cell division
H7R81_RS20030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7R81_RS20035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H7R81_RS20040	COG0772	Belongs to the SEDS family
H7R81_RS20045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H7R81_RS20050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7R81_RS20055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7R81_RS20065	COG0768	penicillin binding
H7R81_RS20070	COG3116	cell division
H7R81_RS20075	COG0275	rRNA processing
H7R81_RS20080	COG2001	Belongs to the MraZ family
H7R81_RS20090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H7R81_RS20095	COG3107	peptidoglycan biosynthetic process
H7R81_RS20100	COG0792	nuclease activity
H7R81_RS20105	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H7R81_RS20115	COG2969	positive regulation of protein catabolic process
H7R81_RS20120	COG0625	glutathione transferase activity
H7R81_RS20125	COG2857	Cytochrome c1
H7R81_RS20130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7R81_RS20135	COG0723	plastoquinol--plastocyanin reductase activity
H7R81_RS20140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H7R81_RS20145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7R81_RS20150	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7R81_RS20160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R81_RS20165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7R81_RS20170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R81_RS20175	COG1660	Displays ATPase and GTPase activities
H7R81_RS20180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7R81_RS20190	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7R81_RS20195	COG1137	ATPase activity
H7R81_RS20200	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7R81_RS20205	COG3117	lipopolysaccharide transmembrane transporter activity
H7R81_RS20210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7R81_RS20215	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H7R81_RS20215	COG0517	IMP dehydrogenase activity
H7R81_RS20220	COG1127	ABC transporter
H7R81_RS20225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7R81_RS20230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7R81_RS20235	COG2854	intermembrane phospholipid transfer
H7R81_RS20245	COG5007	Belongs to the BolA IbaG family
H7R81_RS20250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H7R81_RS20255	COG0312	modulator of DNA gyrase
H7R81_RS20260	COG3028	Belongs to the UPF0307 family
H7R81_RS20265	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7R81_RS20285	COG1011	Hydrolase
H7R81_RS20300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H7R81_RS20305	COG0019	diaminopimelate decarboxylase activity
H7R81_RS20315	COG1965	Belongs to the frataxin family
H7R81_RS20320	COG0400	carboxylic ester hydrolase activity
H7R81_RS20325	COG3072	Adenylate cyclase
H7R81_RS20330	COG0181	hydroxymethylbilane synthase activity
H7R81_RS20340	COG2959	enzyme of heme biosynthesis
H7R81_RS20355	COG1494	fructose-1,6-bisphosphatase
H7R81_RS20410	COG0795	lipopolysaccharide-transporting ATPase activity
H7R81_RS20415	COG0795	lipopolysaccharide-transporting ATPase activity
H7R81_RS20420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H7R81_RS20425	COG2927	DNA polymerase III (CHI subunit)
H7R81_RS20450	COG0456	acetyltransferase
H7R81_RS20450	COG0454	-acetyltransferase
H7R81_RS20455	COG0753	catalase activity
H7R81_RS20480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H7R81_RS20485	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H7R81_RS20490	COG5380	lipid catabolic process
H7R81_RS20510	COG4533	DNA binding
H7R81_RS20520	COG2873	o-acetylhomoserine
H7R81_RS20550	COG3842	ATPase activity
H7R81_RS20560	COG1175	transmembrane transport
H7R81_RS20585	COG3069	C4-dicarboxylate transmembrane transporter activity
H7R81_RS20625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7R81_RS20630	COG1074	ATP-dependent DNA helicase activity
H7R81_RS20635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7R81_RS20640	COG2259	Doxx family
H7R81_RS20645	COG1741	Belongs to the pirin family
H7R81_RS20655	COG0583	DNA-binding transcription factor activity
H7R81_RS20685	COG3706	GGDEF domain
H7R81_RS20690	COG4771	TonB-dependent receptor
H7R81_RS20695	COG4584	PFAM Integrase catalytic
H7R81_RS20700	COG1484	DNA-dependent DNA replication
H7R81_RS20740	COG0203	ribosomal protein L17
H7R81_RS20745	COG0202	RNA polymerase activity
H7R81_RS20750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7R81_RS20755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H7R81_RS20760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7R81_RS20765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7R81_RS20770	COG0201	protein transport
H7R81_RS20775	COG0200	Binds to the 23S rRNA
H7R81_RS20780	COG1841	ribosomal large subunit assembly
H7R81_RS20785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H7R81_RS20790	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H7R81_RS20795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H7R81_RS20800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H7R81_RS20805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H7R81_RS20810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H7R81_RS20815	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H7R81_RS20820	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H7R81_RS20825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H7R81_RS20830	COG0255	Belongs to the universal ribosomal protein uL29 family
H7R81_RS20835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7R81_RS20840	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H7R81_RS20845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H7R81_RS20850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H7R81_RS20855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H7R81_RS20860	COG0089	rRNA binding
H7R81_RS20865	COG0088	Forms part of the polypeptide exit tunnel
H7R81_RS20870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H7R81_RS20875	COG0051	transcription antitermination factor activity, RNA binding
H7R81_RS20895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H7R81_RS20900	COG2183	response to ionizing radiation
H7R81_RS20920	COG0596	Alpha beta hydrolase
H7R81_RS20925	COG1040	competence protein
H7R81_RS20930	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H7R81_RS20930	COG0316	Belongs to the HesB IscA family
H7R81_RS20935	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H7R81_RS20940	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H7R81_RS20945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R81_RS20950	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H7R81_RS20955	COG4942	peptidase
H7R81_RS20965	COG1609	Transcriptional regulator
H7R81_RS20970	COG0800	Aldolase
H7R81_RS20975	COG0129	dihydroxy-acid dehydratase activity
H7R81_RS20980	COG3265	gluconokinase activity
H7R81_RS20985	COG2610	gluconate transmembrane transporter activity
H7R81_RS20990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7R81_RS20995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7R81_RS21005	COG0456	acetyltransferase
H7R81_RS21010	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H7R81_RS21015	COG1490	D-aminoacyl-tRNA deacylase activity
H7R81_RS21020	COG1295	ribonuclease BN
H7R81_RS21025	COG0281	malic enzyme
H7R81_RS21030	COG0814	amino acid
H7R81_RS21035	COG0702	epimerase
H7R81_RS21045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7R81_RS21050	COG0254	rRNA binding
H7R81_RS21065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7R81_RS21070	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7R81_RS21080	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H7R81_RS21090	COG0514	ATP-dependent DNA helicase (RecQ)
H7R81_RS21095	COG0514	ATP-dependent DNA helicase (RecQ)
H7R81_RS21100	COG2050	protein possibly involved in aromatic compounds catabolism
H7R81_RS21120	COG2258	MOSC domain
H7R81_RS21125	COG1177	transmembrane transport
H7R81_RS21130	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7R81_RS21135	COG3842	ATPase activity
H7R81_RS21155	COG0174	glutamine synthetase
H7R81_RS21175	COG3045	CreA protein
H7R81_RS21180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7R81_RS21185	COG0443	Heat shock 70 kDa protein
H7R81_RS21200	COG0366	Alpha amylase catalytic
H7R81_RS21215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7R81_RS21225	COG4211	Belongs to the binding-protein-dependent transport system permease family
H7R81_RS21240	COG3250	beta-galactosidase activity
H7R81_RS21245	COG1609	Transcriptional regulator
H7R81_RS21250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7R81_RS21255	COG1085	galactose-1-phosphate uridylyltransferase
H7R81_RS21260	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H7R81_RS21265	COG2017	converts alpha-aldose to the beta-anomer
H7R81_RS21270	COG1968	undecaprenyl-diphosphatase activity
H7R81_RS21280	COG1595	DNA-templated transcription, initiation
H7R81_RS21290	COG0018	arginyl-trna synthetase
H7R81_RS21300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H7R81_RS21305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H7R81_RS21315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7R81_RS21320	COG1131	(ABC) transporter
H7R81_RS21325	COG0842	Transport permease protein
H7R81_RS21330	COG0842	Transport permease protein
H7R81_RS21335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H7R81_RS21345	COG2116	formate transmembrane transporter activity
H7R81_RS21350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H7R81_RS21350	COG1648	precorrin-2 dehydrogenase activity
H7R81_RS21355	COG2239	Acts as a magnesium transporter
H7R81_RS21360	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7R81_RS21365	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7R81_RS21370	COG3845	ABC transporter
H7R81_RS21375	COG1744	ABC transporter substrate-binding protein PnrA-like
H7R81_RS21380	COG0210	DNA helicase
H7R81_RS21385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H7R81_RS21430	COG1280	lysine exporter protein (LysE YggA)
H7R81_RS21460	COG3307	-O-antigen
H7R81_RS21470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H7R81_RS21485	COG1063	alcohol dehydrogenase
H7R81_RS21490	COG3245	cytochrome
H7R81_RS21505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7R81_RS21510	COG2166	iron-sulfur cluster assembly
H7R81_RS21515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7R81_RS21540	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H7R81_RS21545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7R81_RS21550	COG1739	Uncharacterized protein family UPF0029
H7R81_RS21555	COG0006	proline dipeptidase activity
H7R81_RS21560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H7R81_RS21565	COG1024	Enoyl-CoA hydratase
H7R81_RS21565	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7R81_RS21570	COG0183	Belongs to the thiolase family
H7R81_RS21595	COG0425	Belongs to the sulfur carrier protein TusA family
H7R81_RS21600	COG0251	oxidation-reduction process
H7R81_RS21605	COG2885	chlorophyll binding
H7R81_RS21620	COG2818	Glycosylase
H7R81_RS21625	COG0752	glycyl-tRNA synthetase alpha subunit
H7R81_RS21630	COG0751	glycine-tRNA ligase activity
H7R81_RS21675	COG1609	Transcriptional regulator
H7R81_RS21705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7R81_RS21720	COG2960	long-chain fatty acid transporting porin activity
H7R81_RS21725	COG5002	protein histidine kinase activity
H7R81_RS21725	COG5001	Diguanylate cyclase
H7R81_RS21735	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H7R81_RS21750	COG3118	belongs to the thioredoxin family
H7R81_RS21755	COG0513	Belongs to the DEAD box helicase family
H7R81_RS21760	COG0248	Ppx GppA phosphatase
H7R81_RS21770	COG0742	ribosomal rna small subunit methyltransferase
H7R81_RS21785	COG3469	chitinase activity
H7R81_RS21795	COG0084	hydrolase, TatD family'
H7R81_RS21800	COG0805	protein transport
H7R81_RS21805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R81_RS21810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H7R81_RS21815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H7R81_RS21820	COG3165	ubiquinone biosynthetic process from chorismate
H7R81_RS21825	COG2226	methyltransferase
H7R81_RS21830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7R81_RS21835	COG0402	S-adenosylhomocysteine deaminase activity
H7R81_RS21840	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H7R81_RS21875	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H7R81_RS21880	COG0848	biopolymer transport protein
H7R81_RS21885	COG0811	peptide transport
H7R81_RS21890	COG0811	peptide transport
H7R81_RS21900	COG2771	luxR family
H7R81_RS21905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H7R81_RS21910	COG1349	DNA-binding transcription factor activity
H7R81_RS21915	COG0745	RESPONSE REGULATOR receiver
H7R81_RS21920	COG2205	protein histidine kinase activity
H7R81_RS21935	COG4452	Inner membrane protein CreD
H7R81_RS21940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H7R81_RS21945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H7R81_RS21950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H7R81_RS21955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H7R81_RS21960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H7R81_RS21965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H7R81_RS21970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H7R81_RS21980	COG0356	it plays a direct role in the translocation of protons across the membrane
H7R81_RS21990	COG1475	DNA binding
H7R81_RS21995	COG1192	Involved in chromosome partitioning
H7R81_RS22000	COG0357	Ribosomal RNA small subunit methyltransferase G
H7R81_RS22005	COG0445	tRNA wobble uridine modification
H7R81_RS22010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H7R81_RS22015	COG4774	siderophore transport
H7R81_RS22020	COG4615	Cyclic peptide transporter
H7R81_RS22025	COG1120	ATPase activity
H7R81_RS22030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7R81_RS22040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H7R81_RS22045	COG0706	membrane insertase activity
H7R81_RS22050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H7R81_RS22055	COG0594	ribonuclease P activity
H7R81_RS22060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H7R81_RS22065	COG1126	abc transporter atp-binding protein
H7R81_RS22080	COG4584	PFAM Integrase catalytic
H7R81_RS22085	COG1484	DNA-dependent DNA replication
H7R81_RS22095	COG2132	Multicopper oxidase
H7R81_RS22110	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
H7R81_RS22155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R81_RS22170	COG1937	Protein conserved in bacteria
H7R81_RS22175	COG2814	Major facilitator Superfamily
H7R81_RS22195	COG1238	metal cluster binding
H7R81_RS22240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H7R81_RS22280	COG1192	Involved in chromosome partitioning
H7R81_RS22295	COG2916	Histone family protein nucleoid-structuring protein H-NS
H7R81_RS22345	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7R81_RS22355	COG4804	nuclease activity
H7R81_RS22360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7R81_RS22370	COG4584	PFAM Integrase catalytic
H7R81_RS22375	COG1484	DNA-dependent DNA replication
H7R81_RS22410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H7R81_RS22455	COG2003	Belongs to the UPF0758 family
H7R81_RS22640	COG3385	transposase activity
H7R81_RS22700	COG0488	(ABC) transporter
H7R81_RS22720	COG1028	Short-chain dehydrogenase reductase Sdr
H7R81_RS22730	COG1349	DNA-binding transcription factor activity