locus-tag	class	description
CVS42_RS00010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CVS42_RS00015	COG0706	membrane insertase activity
CVS42_RS00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CVS42_RS00025	COG0594	ribonuclease P activity
CVS42_RS00030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CVS42_RS00035	COG1126	abc transporter atp-binding protein
CVS42_RS00050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CVS42_RS00055	COG0592	DNA-directed DNA polymerase activity
CVS42_RS00060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CVS42_RS00075	COG2378	regulation of single-species biofilm formation
CVS42_RS00085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CVS42_RS00090	COG0071	Belongs to the small heat shock protein (HSP20) family
CVS42_RS00095	COG0071	Belongs to the small heat shock protein (HSP20) family
CVS42_RS00100	COG3977	Valine--pyruvate aminotransferase
CVS42_RS00115	COG2814	Major facilitator Superfamily
CVS42_RS00120	COG0745	RESPONSE REGULATOR receiver
CVS42_RS00125	COG2205	protein histidine kinase activity
CVS42_RS00150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS42_RS00155	COG4191	Histidine kinase
CVS42_RS00155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_RS00160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_RS00170	COG1309	transcriptional regulator
CVS42_RS00200	COG0469	pyruvate kinase activity
CVS42_RS00205	COG2271	Major facilitator Superfamily
CVS42_RS00230	COG0561	phosphatase activity
CVS42_RS00235	COG2267	carboxylic ester hydrolase activity
CVS42_RS00245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVS42_RS00250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVS42_RS00255	COG1758	RNA polymerase activity
CVS42_RS00270	COG0859	PFAM glycosyl transferase family 9
CVS42_RS00275	COG3642	lipopolysaccharide core region biosynthetic process
CVS42_RS00315	COG0589	response to stress
CVS42_RS00320	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CVS42_RS00325	COG1528	Iron-storage protein
CVS42_RS00330	COG2081	HI0933 family
CVS42_RS00335	COG3275	phosphorelay sensor kinase activity
CVS42_RS00340	COG3279	Response regulator of the LytR AlgR family
CVS42_RS00345	COG2223	nitrite transmembrane transporter activity
CVS42_RS00350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CVS42_RS00355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CVS42_RS00370	COG0583	DNA-binding transcription factor activity
CVS42_RS00410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CVS42_RS00415	COG2166	iron-sulfur cluster assembly
CVS42_RS00420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CVS42_RS00435	COG3245	cytochrome
CVS42_RS00440	COG1063	alcohol dehydrogenase
CVS42_RS00455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS42_RS00465	COG3307	-O-antigen
CVS42_RS00505	COG1280	lysine exporter protein (LysE YggA)
CVS42_RS00560	COG1943	Transposase
CVS42_RS00565	COG0210	DNA helicase
CVS42_RS00570	COG1744	ABC transporter substrate-binding protein PnrA-like
CVS42_RS00575	COG3845	ABC transporter
CVS42_RS00580	COG4603	Belongs to the binding-protein-dependent transport system permease family
CVS42_RS00585	COG1079	Belongs to the binding-protein-dependent transport system permease family
CVS42_RS00595	COG0737	Belongs to the 5'-nucleotidase family
CVS42_RS00605	COG2239	Acts as a magnesium transporter
CVS42_RS00610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVS42_RS00610	COG1648	precorrin-2 dehydrogenase activity
CVS42_RS00615	COG2116	formate transmembrane transporter activity
CVS42_RS00625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS42_RS00630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CVS42_RS00635	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CVS42_RS00650	COG0018	arginyl-trna synthetase
CVS42_RS00660	COG1595	DNA-templated transcription, initiation
CVS42_RS00670	COG1968	undecaprenyl-diphosphatase activity
CVS42_RS00675	COG2017	converts alpha-aldose to the beta-anomer
CVS42_RS00680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CVS42_RS00685	COG1085	galactose-1-phosphate uridylyltransferase
CVS42_RS00690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVS42_RS00695	COG1609	Transcriptional regulator
CVS42_RS00700	COG3250	beta-galactosidase activity
CVS42_RS00710	COG1129	ABC transporter
CVS42_RS00715	COG4211	Belongs to the binding-protein-dependent transport system permease family
CVS42_RS00725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVS42_RS00740	COG0366	Alpha amylase catalytic
CVS42_RS00755	COG0443	Heat shock 70 kDa protein
CVS42_RS00760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS42_RS00765	COG3045	CreA protein
CVS42_RS00785	COG0174	glutamine synthetase
CVS42_RS00805	COG3842	ATPase activity
CVS42_RS00810	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS42_RS00815	COG1177	transmembrane transport
CVS42_RS00820	COG2258	MOSC domain
CVS42_RS00835	COG2050	protein possibly involved in aromatic compounds catabolism
CVS42_RS00840	COG0514	ATP-dependent DNA helicase (RecQ)
CVS42_RS00850	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CVS42_RS00860	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CVS42_RS00865	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS42_RS00885	COG0254	rRNA binding
CVS42_RS00890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CVS42_RS00900	COG0702	epimerase
CVS42_RS00905	COG0814	amino acid
CVS42_RS00910	COG0281	malic enzyme
CVS42_RS00915	COG1295	ribonuclease BN
CVS42_RS00920	COG1490	D-aminoacyl-tRNA deacylase activity
CVS42_RS00925	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CVS42_RS00930	COG0456	acetyltransferase
CVS42_RS00940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CVS42_RS00945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS42_RS00950	COG2610	gluconate transmembrane transporter activity
CVS42_RS00955	COG3265	gluconokinase activity
CVS42_RS00960	COG0129	dihydroxy-acid dehydratase activity
CVS42_RS00965	COG0800	Aldolase
CVS42_RS00980	COG1609	Transcriptional regulator
CVS42_RS00990	COG4942	peptidase
CVS42_RS00995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CVS42_RS01000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVS42_RS01005	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CVS42_RS01010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CVS42_RS01015	COG0316	Belongs to the HesB IscA family
CVS42_RS01015	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CVS42_RS01020	COG1040	competence protein
CVS42_RS01025	COG0596	Alpha beta hydrolase
CVS42_RS01045	COG2183	response to ionizing radiation
CVS42_RS01050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVS42_RS01070	COG0051	transcription antitermination factor activity, RNA binding
CVS42_RS01075	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CVS42_RS01080	COG0088	Forms part of the polypeptide exit tunnel
CVS42_RS01085	COG0089	rRNA binding
CVS42_RS01090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CVS42_RS01095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CVS42_RS01100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CVS42_RS01105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CVS42_RS01110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CVS42_RS01115	COG0255	Belongs to the universal ribosomal protein uL29 family
CVS42_RS01120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CVS42_RS01125	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CVS42_RS01130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CVS42_RS01135	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CVS42_RS01140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CVS42_RS01145	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CVS42_RS01150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CVS42_RS01155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CVS42_RS01160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CVS42_RS01165	COG1841	ribosomal large subunit assembly
CVS42_RS01170	COG0200	Binds to the 23S rRNA
CVS42_RS01175	COG0201	protein transport
CVS42_RS01180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CVS42_RS01185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CVS42_RS01190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CVS42_RS01195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CVS42_RS01200	COG0202	RNA polymerase activity
CVS42_RS01205	COG0203	ribosomal protein L17
CVS42_RS01240	COG4771	TonB-dependent receptor
CVS42_RS01245	COG3706	GGDEF domain
CVS42_RS01265	COG0583	DNA-binding transcription factor activity
CVS42_RS01275	COG1741	Belongs to the pirin family
CVS42_RS01280	COG2259	Doxx family
CVS42_RS01285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CVS42_RS01290	COG1074	ATP-dependent DNA helicase activity
CVS42_RS01295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CVS42_RS01340	COG1175	transmembrane transport
CVS42_RS01350	COG3842	ATPase activity
CVS42_RS01380	COG2873	o-acetylhomoserine
CVS42_RS01390	COG4533	DNA binding
CVS42_RS01410	COG5380	lipid catabolic process
CVS42_RS01415	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CVS42_RS01420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CVS42_RS01445	COG0753	catalase activity
CVS42_RS01450	COG0456	acetyltransferase
CVS42_RS01450	COG0454	-acetyltransferase
CVS42_RS01475	COG2927	DNA polymerase III (CHI subunit)
CVS42_RS01480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CVS42_RS01485	COG0795	lipopolysaccharide-transporting ATPase activity
CVS42_RS01490	COG0795	lipopolysaccharide-transporting ATPase activity
CVS42_RS01620	COG4695	Portal protein
CVS42_RS01690	COG3620	sequence-specific DNA binding
CVS42_RS01710	COG4974	Belongs to the 'phage' integrase family
CVS42_RS01715	COG0582	viral genome integration into host DNA
CVS42_RS01735	COG0840	transmembrane signaling receptor activity
CVS42_RS01740	COG1752	Esterase of the alpha-beta hydrolase superfamily
CVS42_RS01745	COG1049	propionate catabolic process, 2-methylcitrate cycle
CVS42_RS01750	COG2200	EAL domain
CVS42_RS01760	COG0523	cobalamin synthesis protein
CVS42_RS01765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_RS01780	COG0477	Major facilitator Superfamily
CVS42_RS01795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CVS42_RS01800	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CVS42_RS01825	COG3314	Sporulation integral membrane protein YlbJ
CVS42_RS01835	COG0165	Argininosuccinate lyase
CVS42_RS01840	COG0137	argininosuccinate synthase activity
CVS42_RS01850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVS42_RS01855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CVS42_RS01865	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CVS42_RS01880	COG0582	viral genome integration into host DNA
CVS42_RS01885	COG2926	Belongs to the UPF0265 family
CVS42_RS01895	COG0561	phosphatase activity
CVS42_RS01905	COG1546	Belongs to the CinA family
CVS42_RS01905	COG1058	Belongs to the CinA family
CVS42_RS01915	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CVS42_RS01925	COG1522	sequence-specific DNA binding
CVS42_RS01930	COG1368	sulfuric ester hydrolase activity
CVS42_RS01965	COG4221	oxidoreductase activity
CVS42_RS01980	COG1979	alcohol dehydrogenase
CVS42_RS01985	COG1803	Methylglyoxal synthase
CVS42_RS02010	COG1444	tRNA N-acetyltransferase activity
CVS42_RS02015	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_RS02020	COG0784	Response regulator, receiver
CVS42_RS02020	COG0835	chemotaxis
CVS42_RS02030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CVS42_RS02035	COG2949	membrane
CVS42_RS02040	COG3291	Pkd domain containing protein
CVS42_RS02045	COG0318	PFAM AMP-dependent synthetase and ligase
CVS42_RS02050	COG1441	menaquinone biosynthetic process
CVS42_RS02055	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CVS42_RS02060	COG0596	Alpha beta hydrolase
CVS42_RS02065	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CVS42_RS02070	COG1169	isochorismate synthase
CVS42_RS02075	COG1575	Belongs to the MenA family. Type 1 subfamily
CVS42_RS02095	COG0513	Belongs to the DEAD box helicase family
CVS42_RS02100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CVS42_RS02105	COG1988	membrane-bound metal-dependent
CVS42_RS02110	COG1671	Belongs to the UPF0178 family
CVS42_RS02130	COG0484	heat shock protein binding
CVS42_RS02135	COG3722	fumarate hydratase activity
CVS42_RS02140	COG0246	Mannitol dehydrogenase
CVS42_RS02145	COG2213	PTS system mannitol-specific
CVS42_RS02145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_RS02150	COG1560	Kdo2-lipid A biosynthetic process
CVS42_RS02155	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CVS42_RS02155	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CVS42_RS02160	COG1538	Outer membrane efflux protein
CVS42_RS02165	COG0494	nUDIX hydrolase
CVS42_RS02170	COG3151	Protein conserved in bacteria
CVS42_RS02180	COG3150	esterase
CVS42_RS02200	COG0583	DNA-binding transcription factor activity
CVS42_RS02210	COG3104	oligopeptide transport
CVS42_RS02240	COG2084	Dehydrogenase
CVS42_RS02245	COG0583	DNA-binding transcription factor activity
CVS42_RS02250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS42_RS02270	COG0204	Acyl-transferase
CVS42_RS02275	COG1842	Phage shock protein A
CVS42_RS02290	COG2827	Endonuclease containing a URI domain
CVS42_RS02305	COG1573	uracil-dna glycosylase
CVS42_RS02310	COG0697	spore germination
CVS42_RS02315	COG0583	DNA-binding transcription factor activity
CVS42_RS02320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CVS42_RS02325	COG1121	(ABC) transporter
CVS42_RS02330	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CVS42_RS02350	COG0739	heme binding
CVS42_RS02360	COG3068	Protein conserved in bacteria
CVS42_RS02380	COG0617	tRNA 3'-terminal CCA addition
CVS42_RS02385	COG1194	a g-specific adenine glycosylase
CVS42_RS02390	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CVS42_RS02400	COG3111	PFAM Bacterial OB fold (BOF) protein
CVS42_RS02405	COG3240	lipase activity
CVS42_RS02410	COG2885	chlorophyll binding
CVS42_RS02410	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CVS42_RS02415	COG3706	GGDEF domain
CVS42_RS02420	COG0557	exoribonuclease II activity
CVS42_RS02480	COG3829	transcription factor binding
CVS42_RS02510	COG3501	Rhs element vgr protein
CVS42_RS02515	COG4104	PAAR repeat-containing protein
CVS42_RS02550	COG0673	inositol 2-dehydrogenase activity
CVS42_RS02560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CVS42_RS02565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVS42_RS02590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVS42_RS02600	COG2153	protein acetylation
CVS42_RS02605	COG0513	Belongs to the DEAD box helicase family
CVS42_RS02610	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CVS42_RS02635	COG0735	belongs to the Fur family
CVS42_RS02640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CVS42_RS02675	COG0840	transmembrane signaling receptor activity
CVS42_RS02685	COG4166	transmembrane transport
CVS42_RS02695	COG0110	maltose O-acetyltransferase activity
CVS42_RS02705	COG1024	Enoyl-CoA hydratase
CVS42_RS02720	COG4221	oxidoreductase activity
CVS42_RS02725	COG0442	prolyl-tRNA aminoacylation
CVS42_RS02730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVS42_RS02740	COG3008	intermembrane lipid transfer
CVS42_RS02740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CVS42_RS02745	COG2995	paraquat-inducible protein a
CVS42_RS02755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS42_RS02765	COG2203	Gaf domain
CVS42_RS02765	COG5001	Diguanylate cyclase
CVS42_RS02765	COG4251	negative regulation of phosphorylation
CVS42_RS02765	COG3706	GGDEF domain
CVS42_RS02770	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CVS42_RS02785	COG2771	luxR family
CVS42_RS02795	COG0840	transmembrane signaling receptor activity
CVS42_RS02800	COG0632	four-way junction helicase activity
CVS42_RS02805	COG2255	four-way junction helicase activity
CVS42_RS02815	COG1294	oxidase, subunit
CVS42_RS02820	COG4890	Cyd operon protein YbgT
CVS42_RS02825	COG3790	cyd operon protein YbgE
CVS42_RS02830	COG0824	Thioesterase
CVS42_RS02835	COG0811	peptide transport
CVS42_RS02850	COG0823	Involved in the tonB-independent uptake of proteins
CVS42_RS02855	COG2885	chlorophyll binding
CVS42_RS02860	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CVS42_RS02895	COG0733	neurotransmitter:sodium symporter activity
CVS42_RS02905	COG0733	neurotransmitter:sodium symporter activity
CVS42_RS02920	COG0561	phosphatase activity
CVS42_RS02970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CVS42_RS02975	COG1640	4-alpha-glucanotransferase
CVS42_RS02985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CVS42_RS02990	COG0676	glucose-6-phosphate 1-epimerase activity
CVS42_RS02995	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CVS42_RS03000	COG0840	transmembrane signaling receptor activity
CVS42_RS03005	COG1585	Membrane protein implicated in regulation of membrane protease activity
CVS42_RS03010	COG0330	HflC and HflK could
CVS42_RS03015	COG1648	precorrin-2 dehydrogenase activity
CVS42_RS03015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVS42_RS03020	COG0175	sulfate reduction
CVS42_RS03025	COG2895	sulfate adenylyltransferase (ATP) activity
CVS42_RS03030	COG0471	metal ion transport
CVS42_RS03030	COG3273	potassium ion transport
CVS42_RS03035	COG0529	Catalyzes the synthesis of activated sulfate
CVS42_RS03050	COG0840	transmembrane signaling receptor activity
CVS42_RS03070	COG1136	(ABC) transporter
CVS42_RS03085	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CVS42_RS03100	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CVS42_RS03105	COG3437	response regulator, receiver
CVS42_RS03105	COG0784	Response regulator, receiver
CVS42_RS03115	COG2076	Multidrug Resistance protein
CVS42_RS03120	COG2076	Multidrug Resistance protein
CVS42_RS03125	COG0346	lactoylglutathione lyase activity
CVS42_RS03130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVS42_RS03135	COG1643	Atp-dependent helicase
CVS42_RS03145	COG1489	DNA binding
CVS42_RS03150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CVS42_RS03155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS42_RS03165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CVS42_RS03170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CVS42_RS03175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CVS42_RS03185	COG1823	symporter activity
CVS42_RS03210	COG0842	Transport permease protein
CVS42_RS03215	COG1131	(ABC) transporter
CVS42_RS03230	COG0163	prenyltransferase activity
CVS42_RS03235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVS42_RS03240	COG0671	phosphoesterase, PA-phosphatase related
CVS42_RS03245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVS42_RS03250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS42_RS03255	COG1151	hydroxylamine reductase activity
CVS42_RS03260	COG0783	Belongs to the Dps family
CVS42_RS03265	COG3023	N-Acetylmuramoyl-L-alanine amidase
CVS42_RS03270	COG4807	Protein conserved in bacteria
CVS42_RS03280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVS42_RS03285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVS42_RS03290	COG3956	TIGRFAM MazG family protein
CVS42_RS03295	COG0504	CTP synthase activity
CVS42_RS03300	COG0148	phosphopyruvate hydratase activity
CVS42_RS03350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CVS42_RS03360	COG0488	(ABC) transporter
CVS42_RS03365	COG0517	IMP dehydrogenase activity
CVS42_RS03365	COG0617	tRNA 3'-terminal CCA addition
CVS42_RS03365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CVS42_RS03380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS42_RS03395	COG1794	racemase activity, acting on amino acids and derivatives
CVS42_RS03405	COG2731	YhcH YjgK YiaL family protein
CVS42_RS03415	COG0668	transmembrane transport
CVS42_RS03420	COG1376	ErfK ybiS ycfS ynhG family protein
CVS42_RS03430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVS42_RS03435	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CVS42_RS03440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CVS42_RS03450	COG0585	pseudouridine synthase activity
CVS42_RS03455	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CVS42_RS03460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVS42_RS03465	COG1238	metal cluster binding
CVS42_RS03480	COG1902	pentaerythritol trinitrate reductase activity
CVS42_RS03495	COG2957	Belongs to the agmatine deiminase family
CVS42_RS03500	COG0154	amidase activity
CVS42_RS03540	COG0513	Belongs to the DEAD box helicase family
CVS42_RS03545	COG2203	Gaf domain
CVS42_RS03545	COG2199	diguanylate cyclase activity
CVS42_RS03555	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CVS42_RS03605	COG2816	NAD+ diphosphatase activity
CVS42_RS03640	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CVS42_RS03650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVS42_RS03655	COG4991	sh3 domain protein
CVS42_RS03665	COG2816	NAD+ diphosphatase activity
CVS42_RS03670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CVS42_RS03675	COG1940	carbohydrate kinase activity
CVS42_RS03680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CVS42_RS03685	COG0126	phosphoglycerate kinase activity
CVS42_RS03690	COG0191	fructose-bisphosphate aldolase activity
CVS42_RS03695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_RS03740	COG0354	folic acid binding
CVS42_RS03745	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CVS42_RS03755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CVS42_RS03760	COG1595	DNA-templated transcription, initiation
CVS42_RS03765	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CVS42_RS03770	COG3026	antisigma factor binding
CVS42_RS03780	COG0481	GTPase activity
CVS42_RS03785	COG0681	Belongs to the peptidase S26 family
CVS42_RS03800	COG1381	Involved in DNA repair and RecF pathway recombination
CVS42_RS03805	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CVS42_RS03820	COG2350	Protein conserved in bacteria
CVS42_RS03825	COG2917	probably involved in intracellular septation
CVS42_RS03830	COG0076	glutamate decarboxylase activity
CVS42_RS03835	COG1272	protein, Hemolysin III
CVS42_RS03840	COG0569	domain protein
CVS42_RS03840	COG2985	domain, Protein
CVS42_RS03860	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CVS42_RS03885	COG1858	cytochrome C peroxidase
CVS42_RS03895	COG2313	pseudouridylate synthase activity
CVS42_RS03900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS42_RS03940	COG1765	OsmC-like protein
CVS42_RS03955	COG3954	Phosphoribulokinase
CVS42_RS03960	COG3089	Belongs to the UPF0270 family
CVS42_RS03965	COG5001	Diguanylate cyclase
CVS42_RS03965	COG2203	Gaf domain
CVS42_RS03965	COG3706	GGDEF domain
CVS42_RS03965	COG4251	negative regulation of phosphorylation
CVS42_RS03970	COG0429	hydrolase of the alpha beta-hydrolase fold
CVS42_RS03975	COG0784	Response regulator, receiver
CVS42_RS03975	COG0835	chemotaxis
CVS42_RS03985	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CVS42_RS03990	COG1047	Peptidyl-prolyl cis-trans
CVS42_RS03995	COG2900	Belongs to the SlyX family
CVS42_RS04005	COG0545	Peptidyl-prolyl cis-trans isomerase
CVS42_RS04010	COG2204	response regulator
CVS42_RS04030	COG0737	Belongs to the 5'-nucleotidase family
CVS42_RS04050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CVS42_RS04060	COG3340	Belongs to the peptidase S51 family
CVS42_RS04075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS42_RS04085	COG3721	Heme iron utilization protein
CVS42_RS04090	COG0748	coenzyme F420 binding
CVS42_RS04130	COG3501	Rhs element vgr protein
CVS42_RS04140	COG2814	Major facilitator Superfamily
CVS42_RS04150	COG3655	Transcriptional regulator
CVS42_RS04160	COG0784	Response regulator, receiver
CVS42_RS04160	COG2205	protein histidine kinase activity
CVS42_RS04160	COG5002	protein histidine kinase activity
CVS42_RS04170	COG3706	GGDEF domain
CVS42_RS04185	COG3397	chitin binding
CVS42_RS04230	COG0835	chemotaxis
CVS42_RS04230	COG0784	Response regulator, receiver
CVS42_RS04235	COG2755	lipolytic protein G-D-S-L family
CVS42_RS04240	COG4181	ATPase activity
CVS42_RS04245	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CVS42_RS04250	COG1090	epimerase
CVS42_RS04255	COG2200	EAL domain
CVS42_RS04260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS42_RS04265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CVS42_RS04270	COG3171	Protein conserved in bacteria
CVS42_RS04275	COG2066	Belongs to the glutaminase family
CVS42_RS04280	COG2897	thiosulfate sulfurtransferase activity
CVS42_RS04295	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVS42_RS04305	COG2966	Psort location CytoplasmicMembrane, score
CVS42_RS04310	COG3610	response to peptide
CVS42_RS04325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS42_RS04330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CVS42_RS04335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CVS42_RS04350	COG0786	glutamate:sodium symporter activity
CVS42_RS04355	COG0252	asparaginase activity
CVS42_RS04360	COG3139	Protein of unknown function (DUF1315)
CVS42_RS04380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CVS42_RS04385	COG0321	lipoyl(octanoyl) transferase activity
CVS42_RS04390	COG2921	Belongs to the UPF0250 family
CVS42_RS04395	COG1686	Belongs to the peptidase S11 family
CVS42_RS04400	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CVS42_RS04405	COG2951	lytic endotransglycosylase activity
CVS42_RS04410	COG0772	Belongs to the SEDS family
CVS42_RS04415	COG0768	penicillin binding
CVS42_RS04420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CVS42_RS04425	COG0799	negative regulation of ribosome biogenesis
CVS42_RS04430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CVS42_RS04445	COG0495	leucyl-tRNA aminoacylation
CVS42_RS04450	COG2888	peptidyl-tyrosine sulfation
CVS42_RS04455	COG0312	modulator of DNA gyrase
CVS42_RS04465	COG0716	FMN binding
CVS42_RS04470	COG4974	Belongs to the 'phage' integrase family
CVS42_RS04480	COG1970	mechanosensitive ion channel activity
CVS42_RS04495	COG0789	Transcriptional regulator
CVS42_RS04500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CVS42_RS04505	COG4535	Mg2 and Co2 transporter CorC
CVS42_RS04510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CVS42_RS04515	COG1702	phosphate starvation-inducible protein PhoH
CVS42_RS04520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVS42_RS04525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS42_RS04530	COG1335	isochorismatase
CVS42_RS04540	COG3706	GGDEF domain
CVS42_RS04550	COG3706	GGDEF domain
CVS42_RS04560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS42_RS04570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CVS42_RS04580	COG0516	GMP reductase activity
CVS42_RS04590	COG0642	Histidine kinase
CVS42_RS04605	COG4221	oxidoreductase activity
CVS42_RS04630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_RS04645	COG3214	Protein conserved in bacteria
CVS42_RS04655	COG2195	Cleaves the N-terminal amino acid of tripeptides
CVS42_RS04660	COG0700	Nucleoside recognition
CVS42_RS04665	COG3366	ferrous iron transmembrane transporter activity
CVS42_RS04670	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CVS42_RS04675	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CVS42_RS04680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CVS42_RS04685	COG1053	succinate dehydrogenase
CVS42_RS04695	COG0584	glycerophosphoryl diester phosphodiesterase
CVS42_RS04700	COG1511	domain protein
CVS42_RS04700	COG3264	Mechanosensitive ion channel
CVS42_RS04710	COG0739	heme binding
CVS42_RS04720	COG0583	DNA-binding transcription factor activity
CVS42_RS04740	COG0583	DNA-binding transcription factor activity
CVS42_RS04745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CVS42_RS04775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CVS42_RS04780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CVS42_RS04790	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CVS42_RS04795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CVS42_RS04805	COG0180	Tryptophanyl-tRNA synthetase
CVS42_RS04820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVS42_RS04830	COG1012	belongs to the aldehyde dehydrogenase family
CVS42_RS04845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS42_RS04855	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_RS04855	COG1013	pyruvate-flavodoxin oxidoreductase activity
CVS42_RS04855	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CVS42_RS04855	COG0674	pyruvate-flavodoxin oxidoreductase activity
CVS42_RS04860	COG0366	Alpha amylase catalytic
CVS42_RS04870	COG0443	Heat shock 70 kDa protein
CVS42_RS04875	COG2214	Heat shock protein DnaJ domain protein
CVS42_RS04885	COG0657	acetylesterase activity
CVS42_RS04900	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CVS42_RS04910	COG0471	metal ion transport
CVS42_RS04910	COG0490	domain, Protein
CVS42_RS04955	COG0012	GTP binding
CVS42_RS04960	COG0193	aminoacyl-tRNA hydrolase activity
CVS42_RS04965	COG0737	Belongs to the 5'-nucleotidase family
CVS42_RS04970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CVS42_RS04980	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CVS42_RS04985	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CVS42_RS04990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CVS42_RS04995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CVS42_RS05000	COG2890	protein-(glutamine-N5) methyltransferase activity
CVS42_RS05010	COG2912	Transglutaminase-like superfamily
CVS42_RS05015	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CVS42_RS05030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CVS42_RS05045	COG1881	PFAM PEBP family protein
CVS42_RS05050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CVS42_RS05065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CVS42_RS05075	COG0583	DNA-binding transcription factor activity
CVS42_RS05080	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_RS05085	COG0616	signal peptide processing
CVS42_RS05095	COG2211	Major facilitator Superfamily
CVS42_RS05100	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CVS42_RS05110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS42_RS05115	COG0826	peptidase U32
CVS42_RS05140	COG3724	N-succinylarginine dihydrolase activity
CVS42_RS05155	COG0840	transmembrane signaling receptor activity
CVS42_RS05165	COG2971	BadF BadG BcrA BcrD
CVS42_RS05175	COG4608	Belongs to the ABC transporter superfamily
CVS42_RS05180	COG0444	Belongs to the ABC transporter superfamily
CVS42_RS05185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS42_RS05200	COG2205	protein histidine kinase activity
CVS42_RS05200	COG0784	Response regulator, receiver
CVS42_RS05225	COG3385	transposase activity
CVS42_RS05235	COG3220	belongs to the UPF0276 family
CVS42_RS05265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVS42_RS05270	COG1289	transmembrane transporter activity
CVS42_RS05275	COG0303	'Molybdopterin
CVS42_RS05280	COG0746	molybdenum cofactor guanylyltransferase activity
CVS42_RS05290	COG4662	Binding-protein-dependent transport system inner membrane component
CVS42_RS05305	COG3852	Histidine kinase
CVS42_RS05315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CVS42_RS05350	COG3383	formate dehydrogenase (NAD+) activity
CVS42_RS05350	COG3383	formate dehydrogenase (NAD+) activity
CVS42_RS05355	COG0437	4 iron, 4 sulfur cluster binding
CVS42_RS05375	COG0281	malic enzyme
CVS42_RS05395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_RS05430	COG1737	Transcriptional regulator
CVS42_RS05435	COG0469	pyruvate kinase activity
CVS42_RS05455	COG1677	Flagellar hook-basal body complex protein FliE
CVS42_RS05465	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CVS42_RS05520	COG1684	flagellar biosynthetic protein fliR
CVS42_RS05530	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CVS42_RS05555	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CVS42_RS05560	COG2198	Histidine kinase
CVS42_RS05560	COG0784	Response regulator, receiver
CVS42_RS05560	COG0643	Histidine kinase
CVS42_RS05565	COG2201	protein-glutamate methylesterase activity
CVS42_RS05570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CVS42_RS05575	COG1360	Flagellar Motor Protein
CVS42_RS05580	COG1192	Involved in chromosome partitioning
CVS42_RS05590	COG0835	chemotaxis
CVS42_RS05605	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS42_RS05610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS42_RS05615	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS42_RS05620	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CVS42_RS05625	COG1138	Cytochrome C-type biogenesis protein
CVS42_RS05630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS42_RS05635	COG3088	subunit of a heme lyase
CVS42_RS05635	COG4235	cytochrome complex assembly
CVS42_RS05645	COG2853	Lipoprotein
CVS42_RS05655	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CVS42_RS05660	COG2850	peptidyl-arginine hydroxylation
CVS42_RS05665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CVS42_RS05670	COG2915	High frequency lysogenization protein hflD homolog
CVS42_RS05675	COG0482	sulfurtransferase activity
CVS42_RS05685	COG1187	pseudouridine synthase activity
CVS42_RS05695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_RS05700	COG2271	Major facilitator Superfamily
CVS42_RS05705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_RS05705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_RS05705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_RS05725	COG1609	Transcriptional regulator
CVS42_RS05730	COG1263	PTS System
CVS42_RS05730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS42_RS05735	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CVS42_RS05760	COG4792	protein secretion
CVS42_RS05765	COG4791	protein targeting
CVS42_RS05770	COG4794	Type iii secretion
CVS42_RS05775	COG4790	Type iii secretion
CVS42_RS05845	COG0457	Tetratricopeptide repeat
CVS42_RS05935	COG1317	bacterial-type flagellum organization
CVS42_RS05940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CVS42_RS05950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_RS05955	COG1960	acyl-CoA dehydrogenase activity
CVS42_RS05965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CVS42_RS05985	COG0464	growth
CVS42_RS06040	COG2003	Belongs to the UPF0758 family
CVS42_RS06115	COG4983	Phage plasmid primase, P4 family domain protein
CVS42_RS06140	COG2916	Histone family protein nucleoid-structuring protein H-NS
CVS42_RS06170	COG2203	Gaf domain
CVS42_RS06170	COG2200	EAL domain
CVS42_RS06170	COG2199	diguanylate cyclase activity
CVS42_RS06185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_RS06185	COG2205	protein histidine kinase activity
CVS42_RS06205	COG2197	response regulator
CVS42_RS06235	COG2826	transposase and inactivated derivatives, IS30 family
CVS42_RS06245	COG5492	domain, Protein
CVS42_RS06245	COG4932	domain protein
CVS42_RS06290	COG0784	Response regulator, receiver
CVS42_RS06290	COG2205	protein histidine kinase activity
CVS42_RS06300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CVS42_RS06305	COG2867	negative regulation of translational initiation
CVS42_RS06310	COG2914	Belongs to the UPF0125 (RnfH) family
CVS42_RS06315	COG1473	amidohydrolase
CVS42_RS06320	COG1960	acyl-CoA dehydrogenase activity
CVS42_RS06325	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CVS42_RS06330	COG0121	glutamine amidotransferase
CVS42_RS06360	COG2197	response regulator
CVS42_RS06365	COG3850	Histidine kinase
CVS42_RS06370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CVS42_RS06375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS42_RS06385	COG0243	molybdopterin cofactor binding
CVS42_RS06390	COG0437	4 iron, 4 sulfur cluster binding
CVS42_RS06395	COG0348	domain, Protein
CVS42_RS06405	COG3005	denitrification pathway
CVS42_RS06410	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVS42_RS06415	COG0315	cyclic pyranopterin monophosphate synthase activity
CVS42_RS06420	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CVS42_RS06425	COG0314	molybdopterin synthase activity
CVS42_RS06440	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CVS42_RS06445	COG2267	carboxylic ester hydrolase activity
CVS42_RS06460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CVS42_RS06470	COG0302	gtp cyclohydrolase
CVS42_RS06475	COG0840	transmembrane signaling receptor activity
CVS42_RS06480	COG0840	transmembrane signaling receptor activity
CVS42_RS06485	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CVS42_RS06495	COG0583	DNA-binding transcription factor activity
CVS42_RS06500	COG2353	YceI-like domain
CVS42_RS06525	COG2195	Cleaves the N-terminal amino acid of tripeptides
CVS42_RS06535	COG1166	arginine decarboxylase activity
CVS42_RS06545	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CVS42_RS06565	COG0814	amino acid
CVS42_RS06575	COG3681	Belongs to the UPF0597 family
CVS42_RS06580	COG2964	Protein conserved in bacteria
CVS42_RS06590	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CVS42_RS06600	COG0436	Aminotransferase
CVS42_RS06610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CVS42_RS06615	COG0739	heme binding
CVS42_RS06615	COG0741	lytic transglycosylase activity
CVS42_RS06615	COG1196	nuclear chromosome segregation
CVS42_RS06630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS42_RS06640	COG0788	formyltetrahydrofolate deformylase activity
CVS42_RS06645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CVS42_RS06665	COG0791	NLP P60 protein
CVS42_RS06670	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CVS42_RS06680	COG0471	metal ion transport
CVS42_RS06690	COG1388	LysM domain
CVS42_RS06690	COG1376	ErfK ybiS ycfS ynhG family protein
CVS42_RS06700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_RS06705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_RS06710	COG0745	RESPONSE REGULATOR receiver
CVS42_RS06715	COG5000	phosphorelay sensor kinase activity
CVS42_RS06715	COG5002	protein histidine kinase activity
CVS42_RS06740	COG1388	LysM domain
CVS42_RS06740	COG0741	lytic transglycosylase activity
CVS42_RS06745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS42_RS06750	COG2226	methyltransferase
CVS42_RS06755	COG0328	RNA-DNA hybrid ribonuclease activity
CVS42_RS06760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CVS42_RS06770	COG0784	Response regulator, receiver
CVS42_RS06770	COG3437	response regulator, receiver
CVS42_RS06775	COG2375	cellular response to nickel ion
CVS42_RS06780	COG4771	TonB-dependent receptor
CVS42_RS06785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS42_RS06790	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS42_RS06795	COG1120	ATPase activity
CVS42_RS06800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVS42_RS06810	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_RS06815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_RS06840	COG0708	Exodeoxyribonuclease III
CVS42_RS06875	COG3132	Protein of unknown function, DUF480
CVS42_RS06880	COG5001	Diguanylate cyclase
CVS42_RS06880	COG3300	MHYT domain
CVS42_RS06890	COG2841	Protein conserved in bacteria
CVS42_RS06930	COG1309	transcriptional regulator
CVS42_RS06965	COG3152	Membrane
CVS42_RS06980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_RS06995	COG2207	Transcriptional regulator
CVS42_RS07000	COG0538	isocitrate dehydrogenase activity
CVS42_RS07010	COG3048	D-serine ammonia-lyase activity
CVS42_RS07015	COG2610	gluconate transmembrane transporter activity
CVS42_RS07020	COG0583	DNA-binding transcription factor activity
CVS42_RS07030	COG0791	NLP P60 protein
CVS42_RS07035	COG0583	DNA-binding transcription factor activity
CVS42_RS07040	COG0450	alkyl hydroperoxide reductase
CVS42_RS07050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS42_RS07060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CVS42_RS07065	COG1882	Formate acetyltransferase
CVS42_RS07075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS42_RS07075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS42_RS07110	COG0259	pyridoxamine-phosphate oxidase activity
CVS42_RS07165	COG0483	inositol monophosphate 1-phosphatase activity
CVS42_RS07175	COG0625	glutathione transferase activity
CVS42_RS07180	COG2814	Major facilitator Superfamily
CVS42_RS07200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS42_RS07205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS42_RS07215	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CVS42_RS07220	COG0509	glycine decarboxylation via glycine cleavage system
CVS42_RS07225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVS42_RS07225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVS42_RS07230	COG0840	transmembrane signaling receptor activity
CVS42_RS07255	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CVS42_RS07260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CVS42_RS07260	COG0574	Belongs to the PEP-utilizing enzyme family
CVS42_RS07275	COG1464	Belongs to the NlpA lipoprotein family
CVS42_RS07280	COG3083	sulfuric ester hydrolase activity
CVS42_RS07285	COG3082	Protein of unknown function (DUF1414)
CVS42_RS07290	COG3081	Nucleoid-associated protein
CVS42_RS07300	COG1175	transmembrane transport
CVS42_RS07305	COG3833	ABC-type maltose transport systems, permease component
CVS42_RS07310	COG3842	ATPase activity
CVS42_RS07340	COG4783	chaperone-mediated protein folding
CVS42_RS07350	COG1393	Belongs to the ArsC family
CVS42_RS07370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_RS07380	COG2431	L-lysine efflux transmembrane transporter activity
CVS42_RS07390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_RS07400	COG4160	amino acid transport
CVS42_RS07405	COG0564	pseudouridine synthase activity
CVS42_RS07420	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CVS42_RS07430	COG0625	glutathione transferase activity
CVS42_RS07440	COG2801	Transposase and inactivated derivatives
CVS42_RS07455	COG0367	asparagine synthase
CVS42_RS07465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CVS42_RS07465	COG4651	solute:proton antiporter activity
CVS42_RS07470	COG0647	UMP catabolic process
CVS42_RS07485	COG1902	pentaerythritol trinitrate reductase activity
CVS42_RS07490	COG1253	flavin adenine dinucleotide binding
CVS42_RS07500	COG0247	lactate metabolic process
CVS42_RS07500	COG0277	FAD linked oxidase domain protein
CVS42_RS07510	COG2050	protein possibly involved in aromatic compounds catabolism
CVS42_RS07515	COG0513	Belongs to the DEAD box helicase family
CVS42_RS07540	COG3634	alkyl hydroperoxide reductase activity
CVS42_RS07550	COG0517	IMP dehydrogenase activity
CVS42_RS07555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CVS42_RS07560	COG0343	queuine tRNA-ribosyltransferase activity
CVS42_RS07565	COG1862	Preprotein translocase
CVS42_RS07570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS42_RS07575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS42_RS07590	COG0826	peptidase U32
CVS42_RS07595	COG0826	peptidase U32
CVS42_RS07600	COG3154	lipid carrier protein
CVS42_RS07620	COG1104	cysteine desulfurase activity
CVS42_RS07625	COG0822	iron-sulfur transferase activity
CVS42_RS07635	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CVS42_RS07640	COG0443	Heat shock 70 kDa protein
CVS42_RS07645	COG0633	Ferredoxin
CVS42_RS07660	COG0105	UTP biosynthetic process
CVS42_RS07665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CVS42_RS07680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CVS42_RS07685	COG0124	histidyl-tRNA synthetase
CVS42_RS07690	COG2976	Protein conserved in bacteria
CVS42_RS07695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS42_RS07700	COG1160	GTP binding
CVS42_RS07705	COG1645	bacterial-type flagellum-dependent swarming motility
CVS42_RS07715	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CVS42_RS07720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CVS42_RS07720	COG0047	phosphoribosylformylglycinamidine synthase activity
CVS42_RS07725	COG2056	Na+-H+ antiporter family
CVS42_RS07730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CVS42_RS07735	COG0671	phosphoesterase, PA-phosphatase related
CVS42_RS07740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS42_RS07745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CVS42_RS07755	COG0101	tRNA pseudouridine synthase activity
CVS42_RS07760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CVS42_RS07765	COG0285	dihydrofolate synthase activity
CVS42_RS07770	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CVS42_RS07775	COG0393	Putative heavy-metal-binding
CVS42_RS07785	COG1648	precorrin-2 dehydrogenase activity
CVS42_RS07785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVS42_RS07805	COG4667	esterase of the alpha-beta hydrolase superfamily
CVS42_RS07810	COG1619	proteins homologs of microcin C7 resistance protein MccF
CVS42_RS07815	COG1368	sulfuric ester hydrolase activity
CVS42_RS07825	COG0527	aspartate kinase activity
CVS42_RS07830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVS42_RS07830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CVS42_RS07835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS42_RS07855	COG0596	Alpha beta hydrolase
CVS42_RS07865	COG0577	efflux transmembrane transporter activity
CVS42_RS07870	COG1136	(ABC) transporter
CVS42_RS07885	COG2814	Major facilitator Superfamily
CVS42_RS07905	COG0672	)-iron permease
CVS42_RS07975	COG0393	Putative heavy-metal-binding
CVS42_RS08030	COG0582	viral genome integration into host DNA
CVS42_RS08050	COG0659	secondary active sulfate transmembrane transporter activity
CVS42_RS08135	COG2003	Belongs to the UPF0758 family
CVS42_RS08175	COG3311	Transcriptional regulator
CVS42_RS08180	COG4983	Phage plasmid primase, P4 family domain protein
CVS42_RS08195	COG0346	lactoylglutathione lyase activity
CVS42_RS08215	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CVS42_RS08240	COG4104	PAAR repeat-containing protein
CVS42_RS08265	COG0582	viral genome integration into host DNA
CVS42_RS08270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CVS42_RS08275	COG0326	Molecular chaperone. Has ATPase activity
CVS42_RS08280	COG4172	Belongs to the ABC transporter superfamily
CVS42_RS08285	COG4172	Belongs to the ABC transporter superfamily
CVS42_RS08295	COG4168	peptide transport system, permease
CVS42_RS08305	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CVS42_RS08310	COG1842	Phage shock protein A
CVS42_RS08325	COG3106	COG3106 Predicted ATPase
CVS42_RS08330	COG3768	UPF0283 membrane protein
CVS42_RS08340	COG2154	pterin-4-alpha-carbinolamine dehydratase
CVS42_RS08360	COG2199	diguanylate cyclase activity
CVS42_RS08365	COG2885	chlorophyll binding
CVS42_RS08370	COG0861	Integral membrane protein TerC family
CVS42_RS08405	COG2910	NAD(P)H-binding
CVS42_RS08410	COG0583	DNA-binding transcription factor activity
CVS42_RS08415	COG0583	DNA-binding transcription factor activity
CVS42_RS08420	COG2271	Major facilitator Superfamily
CVS42_RS08430	COG1335	isochorismatase
CVS42_RS08445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CVS42_RS08455	COG0583	DNA-binding transcription factor activity
CVS42_RS08460	COG2723	6-phospho-beta-galactosidase activity
CVS42_RS08465	COG1944	ATP diphosphatase activity
CVS42_RS08470	COG2116	formate transmembrane transporter activity
CVS42_RS08475	COG1882	Formate acetyltransferase
CVS42_RS08480	COG2983	Belongs to the UPF0260 family
CVS42_RS08495	COG0058	SHG alpha-glucan phosphorylase activity
CVS42_RS08500	COG0471	metal ion transport
CVS42_RS08505	COG3118	belongs to the thioredoxin family
CVS42_RS08515	COG1132	(ABC) transporter
CVS42_RS08520	COG1132	(ABC) transporter
CVS42_RS08530	COG2501	S4 domain
CVS42_RS08545	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CVS42_RS08590	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CVS42_RS08595	COG1053	succinate dehydrogenase
CVS42_RS08605	COG0567	Dehydrogenase, E1 component
CVS42_RS08610	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS42_RS08615	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS42_RS08625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_RS08635	COG3842	ATPase activity
CVS42_RS08640	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS42_RS08650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CVS42_RS08660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS42_RS08675	COG4235	cytochrome complex assembly
CVS42_RS08675	COG3088	subunit of a heme lyase
CVS42_RS08685	COG1138	Cytochrome C-type biogenesis protein
CVS42_RS08690	COG3301	Polysulphide reductase, NrfD
CVS42_RS08695	COG0437	4 iron, 4 sulfur cluster binding
CVS42_RS08700	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CVS42_RS08715	COG0247	lactate metabolic process
CVS42_RS08720	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CVS42_RS08725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CVS42_RS08730	COG3012	SEC-C Motif Domain Protein
CVS42_RS08735	COG0840	transmembrane signaling receptor activity
CVS42_RS08740	COG1940	carbohydrate kinase activity
CVS42_RS08740	COG1846	Transcriptional regulator
CVS42_RS08745	COG3148	PFAM DTW domain containing protein
CVS42_RS08750	COG0730	response to heat
CVS42_RS08755	COG0583	DNA-binding transcription factor activity
CVS42_RS08770	COG3593	DNA synthesis involved in DNA repair
CVS42_RS08805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CVS42_RS08810	COG1011	Hydrolase
CVS42_RS08825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CVS42_RS08830	COG2832	Protein of unknown function (DUF454)
CVS42_RS08835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CVS42_RS08845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CVS42_RS08850	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CVS42_RS08865	COG1560	Kdo2-lipid A biosynthetic process
CVS42_RS08870	COG1560	Kdo2-lipid A biosynthetic process
CVS42_RS08895	COG0417	DNA replication proofreading
CVS42_RS08910	COG1451	nucleotide metabolic process
CVS42_RS08925	COG3069	C4-dicarboxylate transmembrane transporter activity
CVS42_RS08940	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CVS42_RS08940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_RS08945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS42_RS08950	COG2985	domain, Protein
CVS42_RS08950	COG0569	domain protein
CVS42_RS08960	COG0556	nucleotide-excision repair
CVS42_RS08970	COG0586	Pfam SNARE associated Golgi protein
CVS42_RS08975	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CVS42_RS08980	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVS42_RS08995	COG4681	YaeQ
CVS42_RS09010	COG3829	transcription factor binding
CVS42_RS09055	COG0307	riboflavin synthase, alpha
CVS42_RS09065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS42_RS09070	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CVS42_RS09075	COG0697	spore germination
CVS42_RS09080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CVS42_RS09120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVS42_RS09125	COG3099	Belongs to the UPF0263 family
CVS42_RS09130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CVS42_RS09135	COG2894	cell division
CVS42_RS09140	COG0850	regulation of cytokinetic process
CVS42_RS09145	COG3100	YcgL domain-containing protein
CVS42_RS09150	COG1760	l-serine dehydratase
CVS42_RS09160	COG1760	l-serine dehydratase
CVS42_RS09165	COG3123	guanosine phosphorylase activity
CVS42_RS09175	COG0205	6-phosphofructokinase activity
CVS42_RS09185	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CVS42_RS09190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVS42_RS09200	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CVS42_RS09205	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CVS42_RS09210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CVS42_RS09225	COG0242	peptide deformylase activity
CVS42_RS09260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CVS42_RS09265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS42_RS09270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS42_RS09280	COG0549	Belongs to the carbamate kinase family
CVS42_RS09285	COG0697	spore germination
CVS42_RS09290	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CVS42_RS09290	COG3608	succinylglutamate desuccinylase aspartoacylase
CVS42_RS09295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVS42_RS09300	COG2068	MobA-Related Protein
CVS42_RS09305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS42_RS09305	COG0493	'glutamate synthase
CVS42_RS09310	COG0402	S-adenosylhomocysteine deaminase activity
CVS42_RS09315	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CVS42_RS09320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVS42_RS09320	COG2080	2 iron, 2 sulfur cluster binding
CVS42_RS09325	COG2233	PERMEase
CVS42_RS09330	COG0402	S-adenosylhomocysteine deaminase activity
CVS42_RS09335	COG2252	PERMEase
CVS42_RS09340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVS42_RS09345	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CVS42_RS09350	COG2080	2 iron, 2 sulfur cluster binding
CVS42_RS09355	COG3134	Outer membrane lipoprotein
CVS42_RS09365	COG0318	PFAM AMP-dependent synthetase and ligase
CVS42_RS09370	COG2199	diguanylate cyclase activity
CVS42_RS09385	COG0107	imidazoleglycerol-phosphate synthase activity
CVS42_RS09390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CVS42_RS09395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CVS42_RS09400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CVS42_RS09400	COG0131	Imidazoleglycerol-phosphate dehydratase
CVS42_RS09405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVS42_RS09410	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CVS42_RS09415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CVS42_RS09425	COG1199	ATP-dependent helicase activity
CVS42_RS09430	COG1214	PFAM Peptidase M22, glycoprotease
CVS42_RS09440	COG2267	carboxylic ester hydrolase activity
CVS42_RS09445	COG0318	PFAM AMP-dependent synthetase and ligase
CVS42_RS09460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS42_RS09465	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CVS42_RS09470	COG0709	Synthesizes selenophosphate from selenide and ATP
CVS42_RS09500	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CVS42_RS09505	COG0840	transmembrane signaling receptor activity
CVS42_RS09510	COG1254	Belongs to the acylphosphatase family
CVS42_RS09520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS42_RS09520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS42_RS09525	COG0489	protein tyrosine kinase activity
CVS42_RS09530	COG0572	uridine kinase
CVS42_RS09535	COG0717	Belongs to the dCTP deaminase family
CVS42_RS09540	COG0306	phosphate transporter
CVS42_RS09545	COG3313	Fe-S protein
CVS42_RS09550	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CVS42_RS09555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS42_RS09560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CVS42_RS09565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CVS42_RS09575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVS42_RS09585	COG0366	Alpha amylase catalytic
CVS42_RS09600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CVS42_RS09605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CVS42_RS09610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CVS42_RS09615	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CVS42_RS09620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CVS42_RS09625	COG0072	phenylalanine-tRNA ligase activity
CVS42_RS09625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS42_RS09630	COG0776	regulation of translation
CVS42_RS09635	COG2205	protein histidine kinase activity
CVS42_RS09635	COG0784	Response regulator, receiver
CVS42_RS09660	COG5001	Diguanylate cyclase
CVS42_RS09660	COG3300	MHYT domain
CVS42_RS09665	COG1609	Transcriptional regulator
CVS42_RS09670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS42_RS09675	COG1879	ABC-type sugar transport system periplasmic component
CVS42_RS09680	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVS42_RS09685	COG1129	ABC transporter
CVS42_RS09690	COG1869	D-ribose catabolic process
CVS42_RS09695	COG0625	glutathione transferase activity
CVS42_RS09705	COG5654	RES domain protein
CVS42_RS09720	COG1177	transmembrane transport
CVS42_RS09745	COG0037	tRNA processing
CVS42_RS09750	COG0589	response to stress
CVS42_RS09755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVS42_RS09770	COG2217	Heavy metal translocating P-type atpase
CVS42_RS09780	COG2010	Cytochrome c
CVS42_RS09795	COG3278	Belongs to the heme-copper respiratory oxidase family
CVS42_RS09805	COG1956	GAF domain-containing protein
CVS42_RS09810	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CVS42_RS09820	COG0308	aminopeptidase N
CVS42_RS09830	COG2902	Dehydrogenase
CVS42_RS09835	COG0167	dihydroorotate dehydrogenase activity
CVS42_RS09850	COG0254	rRNA binding
CVS42_RS09855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CVS42_RS09860	COG0116	Belongs to the methyltransferase superfamily
CVS42_RS09860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CVS42_RS09870	COG0488	(ABC) transporter
CVS42_RS09880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVS42_RS09885	COG1067	ATP-dependent peptidase activity
CVS42_RS09970	COG3141	response to X-ray
CVS42_RS09975	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CVS42_RS09980	COG4221	oxidoreductase activity
CVS42_RS10025	COG0372	Belongs to the citrate synthase family
CVS42_RS10030	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CVS42_RS10040	COG2995	paraquat-inducible protein a
CVS42_RS10045	COG3008	intermembrane lipid transfer
CVS42_RS10050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS42_RS10050	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CVS42_RS10065	COG0084	hydrolase, TatD family'
CVS42_RS10070	COG0470	DNA polymerase III
CVS42_RS10075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CVS42_RS10080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CVS42_RS10085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CVS42_RS10090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS42_RS10095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVS42_RS10100	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_RS10110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVS42_RS10115	COG0416	fatty acid biosynthetic process
CVS42_RS10120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CVS42_RS10125	COG1399	metal-binding, possibly nucleic acid-binding protein
CVS42_RS10130	COG0424	maF-like protein
CVS42_RS10145	COG1530	ribonuclease E activity
CVS42_RS10155	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CVS42_RS10155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_RS10155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_RS10160	COG1105	Belongs to the carbohydrate kinase PfkB family
CVS42_RS10165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_RS10165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_RS10170	COG1609	Transcriptional regulator
CVS42_RS10175	COG0814	amino acid
CVS42_RS10185	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CVS42_RS10200	COG0513	Belongs to the DEAD box helicase family
CVS42_RS10210	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CVS42_RS10215	COG2890	protein-(glutamine-N5) methyltransferase activity
CVS42_RS10220	COG2840	Smr protein MutS2
CVS42_RS10225	COG3706	GGDEF domain
CVS42_RS10230	COG0406	alpha-ribazole phosphatase activity
CVS42_RS10255	COG2824	Alkylphosphonate utilization operon protein PhnA
CVS42_RS10275	COG0814	amino acid
CVS42_RS10280	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CVS42_RS10290	COG0514	ATP-dependent DNA helicase (RecQ)
CVS42_RS10295	COG2766	serine protein kinase
CVS42_RS10300	COG2718	Belongs to the UPF0229 family
CVS42_RS10305	COG2719	SpoVR family
CVS42_RS10310	COG1024	Enoyl-CoA hydratase
CVS42_RS10310	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS42_RS10315	COG0183	Belongs to the thiolase family
CVS42_RS10320	COG0714	Associated with various cellular activities
CVS42_RS10340	COG2304	oxidoreductase activity
CVS42_RS10350	COG1595	DNA-templated transcription, initiation
CVS42_RS10360	COG2067	long-chain fatty acid transport protein
CVS42_RS10365	COG2067	long-chain fatty acid transport protein
CVS42_RS10370	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CVS42_RS10385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CVS42_RS10395	COG1643	Atp-dependent helicase
CVS42_RS10400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CVS42_RS10400	COG0617	tRNA 3'-terminal CCA addition
CVS42_RS10400	COG0517	IMP dehydrogenase activity
CVS42_RS10405	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVS42_RS10410	COG3119	arylsulfatase activity
CVS42_RS10415	COG0714	Associated with various cellular activities
CVS42_RS10430	COG2304	oxidoreductase activity
CVS42_RS10435	COG2304	oxidoreductase activity
CVS42_RS10460	COG0641	radical SAM
CVS42_RS10465	COG2925	Exonuclease
CVS42_RS10475	COG3345	alpha-galactosidase
CVS42_RS10480	COG1380	Effector of murein hydrolase LrgA
CVS42_RS10485	COG1346	cytolysis
CVS42_RS10490	COG0295	cytidine deaminase activity
CVS42_RS10495	COG3033	Beta-eliminating lyase
CVS42_RS10505	COG3046	protein related to deoxyribodipyrimidine photolyase
CVS42_RS10510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_RS10515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CVS42_RS10540	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS42_RS10555	COG0454	-acetyltransferase
CVS42_RS10565	COG3158	transport of potassium into the cell
CVS42_RS10570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS42_RS10575	COG0651	ATP synthesis coupled electron transport
CVS42_RS10580	COG0650	Formate hydrogenlyase subunit 4
CVS42_RS10585	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CVS42_RS10585	COG3261	NADH dehydrogenase
CVS42_RS10590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_RS10595	COG3260	NADH ubiquinone oxidoreductase 20
CVS42_RS10605	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CVS42_RS10610	COG1921	L-seryl-tRNASec selenium transferase activity
CVS42_RS10620	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CVS42_RS10625	COG0298	carbon dioxide binding
CVS42_RS10635	COG0309	Hydrogenase expression formation protein (HypE)
CVS42_RS10640	COG0375	protein maturation
CVS42_RS10645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CVS42_RS10650	COG1124	(ABC) transporter
CVS42_RS10660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS42_RS10665	COG0601	transmembrane transport
CVS42_RS10670	COG0747	negative chemotaxis
CVS42_RS10675	COG1773	rubredoxin
CVS42_RS10680	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CVS42_RS10685	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CVS42_RS10690	COG5557	Pfam Polysulphide reductase, NrfD
CVS42_RS10695	COG0437	4 iron, 4 sulfur cluster binding
CVS42_RS10700	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CVS42_RS10705	COG5001	Diguanylate cyclase
CVS42_RS10705	COG4251	negative regulation of phosphorylation
CVS42_RS10705	COG3706	GGDEF domain
CVS42_RS10705	COG2203	Gaf domain
CVS42_RS10710	COG0438	transferase activity, transferring glycosyl groups
CVS42_RS10715	COG0438	transferase activity, transferring glycosyl groups
CVS42_RS10735	COG0438	transferase activity, transferring glycosyl groups
CVS42_RS10780	COG0438	transferase activity, transferring glycosyl groups
CVS42_RS10785	COG1215	transferase activity, transferring glycosyl groups
CVS42_RS10790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CVS42_RS10830	COG2205	protein histidine kinase activity
CVS42_RS10830	COG0784	Response regulator, receiver
CVS42_RS10845	COG0730	response to heat
CVS42_RS10860	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_RS10870	COG1024	Enoyl-CoA hydratase
CVS42_RS10875	COG1024	Enoyl-CoA hydratase
CVS42_RS10880	COG1960	acyl-CoA dehydrogenase activity
CVS42_RS10885	COG1960	acyl-CoA dehydrogenase activity
CVS42_RS10890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVS42_RS10895	COG1024	Enoyl-CoA hydratase
CVS42_RS10925	COG1584	GPR1 FUN34 yaaH family protein
CVS42_RS10955	COG1115	amino acid carrier protein
CVS42_RS10960	COG4974	Belongs to the 'phage' integrase family
CVS42_RS10985	COG1024	Enoyl-CoA hydratase
CVS42_RS11000	COG3162	membrane
CVS42_RS11005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVS42_RS11070	COG4584	PFAM Integrase catalytic
CVS42_RS11075	COG1484	DNA-dependent DNA replication
CVS42_RS11085	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CVS42_RS11205	COG1484	DNA-dependent DNA replication
CVS42_RS11210	COG4584	PFAM Integrase catalytic
CVS42_RS11325	COG3314	Sporulation integral membrane protein YlbJ
CVS42_RS11370	COG0582	viral genome integration into host DNA
CVS42_RS11375	COG0488	(ABC) transporter
CVS42_RS11380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS42_RS11385	COG0776	regulation of translation
CVS42_RS11390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CVS42_RS11395	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CVS42_RS11400	COG0740	serine-type endopeptidase activity
CVS42_RS11405	COG0544	peptidyl-prolyl cis-trans isomerase activity
CVS42_RS11420	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CVS42_RS11425	COG4591	ABC-type transport system involved in lipoprotein release permease component
CVS42_RS11430	COG1136	(ABC) transporter
CVS42_RS11435	COG4591	ABC-type transport system involved in lipoprotein release permease component
CVS42_RS11445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CVS42_RS11450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CVS42_RS11455	COG4166	transmembrane transport
CVS42_RS11460	COG0697	spore germination
CVS42_RS11470	COG2062	phosphohistidine phosphatase, SixA
CVS42_RS11475	COG1025	Belongs to the peptidase M16 family
CVS42_RS11510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVS42_RS11510	COG0519	Catalyzes the synthesis of GMP from XMP
CVS42_RS11515	COG0516	GMP reductase activity
CVS42_RS11515	COG0517	IMP dehydrogenase activity
CVS42_RS11525	COG1570	exodeoxyribonuclease VII activity
CVS42_RS11535	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVS42_RS11545	COG0386	Belongs to the glutathione peroxidase family
CVS42_RS11550	COG0513	Belongs to the DEAD box helicase family
CVS42_RS11565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS42_RS11570	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CVS42_RS11575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CVS42_RS11595	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CVS42_RS11595	COG0644	oxidoreductase
CVS42_RS11630	COG5001	Diguanylate cyclase
CVS42_RS11630	COG3300	MHYT domain
CVS42_RS11645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS42_RS11655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CVS42_RS11660	COG0563	adenylate kinase activity
CVS42_RS11670	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CVS42_RS11675	COG1286	toxin biosynthetic process
CVS42_RS11680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CVS42_RS11685	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CVS42_RS11690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CVS42_RS11695	COG1674	ftsk spoiiie
CVS42_RS11695	COG0531	amino acid
CVS42_RS11705	COG0686	Belongs to the AlaDH PNT family
CVS42_RS11710	COG0492	ferredoxin-NADP+ reductase activity
CVS42_RS11715	COG3706	GGDEF domain
CVS42_RS11720	COG3134	Outer membrane lipoprotein
CVS42_RS11725	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CVS42_RS11730	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CVS42_RS11735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CVS42_RS11740	COG0542	response to heat
CVS42_RS11745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CVS42_RS11750	COG1278	Cold shock
CVS42_RS11755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CVS42_RS11775	COG0745	RESPONSE REGULATOR receiver
CVS42_RS11780	COG2205	protein histidine kinase activity
CVS42_RS11790	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CVS42_RS11790	COG0392	lysyltransferase activity
CVS42_RS11830	COG1435	thymidine kinase activity
CVS42_RS11835	COG1757	Na H antiporter
CVS42_RS11840	COG2916	Histone family protein nucleoid-structuring protein H-NS
CVS42_RS11845	COG2096	Adenosyltransferase
CVS42_RS11850	COG3530	Putative quorum-sensing-regulated virulence factor
CVS42_RS11855	COG0602	queuosine metabolic process
CVS42_RS11860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CVS42_RS11880	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CVS42_RS11890	COG0776	regulation of translation
CVS42_RS11895	COG0539	negative regulation of cytoplasmic translation
CVS42_RS11900	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CVS42_RS11905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CVS42_RS11920	COG2814	Major facilitator Superfamily
CVS42_RS11940	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CVS42_RS11945	COG3300	MHYT domain
CVS42_RS11945	COG5001	Diguanylate cyclase
CVS42_RS11950	COG0583	DNA-binding transcription factor activity
CVS42_RS11955	COG3437	response regulator, receiver
CVS42_RS11980	COG4989	oxidoreductase activity
CVS42_RS11985	COG0724	RNA recognition motif
CVS42_RS11995	COG1126	abc transporter atp-binding protein
CVS42_RS12000	COG0765	amino acid transport
CVS42_RS12005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_RS12010	COG4597	amino acid ABC transporter
CVS42_RS12015	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CVS42_RS12025	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CVS42_RS12050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CVS42_RS12060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CVS42_RS12065	COG1360	Flagellar Motor Protein
CVS42_RS12070	COG4771	TonB-dependent receptor
CVS42_RS12075	COG1770	oligopeptidase
CVS42_RS12095	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_RS12100	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_RS12105	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_RS12105	COG0649	NAD binding
CVS42_RS12120	COG1034	ATP synthesis coupled electron transport
CVS42_RS12125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CVS42_RS12130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_RS12135	COG0839	Belongs to the complex I subunit 6 family
CVS42_RS12140	COG0713	ATP synthesis coupled electron transport
CVS42_RS12150	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_RS12155	COG1007	ATP synthesis coupled electron transport
CVS42_RS12170	COG2199	diguanylate cyclase activity
CVS42_RS12170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVS42_RS12175	COG5001	Diguanylate cyclase
CVS42_RS12175	COG3300	MHYT domain
CVS42_RS12220	COG1242	4 iron, 4 sulfur cluster binding
CVS42_RS12225	COG0067	glutamate synthase
CVS42_RS12225	COG0070	glutamate synthase
CVS42_RS12225	COG0069	glutamate synthase activity
CVS42_RS12230	COG0493	'glutamate synthase
CVS42_RS12245	COG0513	Belongs to the DEAD box helicase family
CVS42_RS12270	COG0023	Translation Initiation Factor
CVS42_RS12275	COG2119	membrane
CVS42_RS12315	COG1061	Type III restriction enzyme res subunit
CVS42_RS12320	COG0215	cysteine-tRNA ligase activity
CVS42_RS12325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CVS42_RS12335	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS42_RS12340	COG2261	transglycosylase associated protein
CVS42_RS12345	COG0642	Histidine kinase
CVS42_RS12375	COG0582	viral genome integration into host DNA
CVS42_RS12400	COG0322	excinuclease ABC activity
CVS42_RS12405	COG2197	response regulator
CVS42_RS12410	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CVS42_RS12415	COG2835	tetraacyldisaccharide 4'-kinase activity
CVS42_RS12420	COG1663	tetraacyldisaccharide 4'-kinase activity
CVS42_RS12430	COG0658	competence protein
CVS42_RS12430	COG2333	competence protein COMEC
CVS42_RS12445	COG1448	Aminotransferase
CVS42_RS12455	COG0583	DNA-binding transcription factor activity
CVS42_RS12460	COG3085	chromosome segregation
CVS42_RS12465	COG4574	serine-type endopeptidase inhibitor activity
CVS42_RS12470	COG0584	glycerophosphoryl diester phosphodiesterase
CVS42_RS12480	COG1349	DNA-binding transcription factor activity
CVS42_RS12485	COG2271	Major facilitator Superfamily
CVS42_RS12490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CVS42_RS12495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CVS42_RS12500	COG0840	transmembrane signaling receptor activity
CVS42_RS12515	COG0583	DNA-binding transcription factor activity
CVS42_RS12540	COG0656	L-ascorbic acid biosynthetic process
CVS42_RS12550	COG2814	Major facilitator Superfamily
CVS42_RS12555	COG2249	NAD(P)H dehydrogenase (quinone) activity
CVS42_RS12570	COG3220	belongs to the UPF0276 family
CVS42_RS12590	COG1294	oxidase, subunit
CVS42_RS12600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS42_RS12610	COG2979	Protein of unknown function (DUF533)
CVS42_RS12625	COG0583	DNA-binding transcription factor activity
CVS42_RS12630	COG2807	transmembrane transport
CVS42_RS12635	COG1187	pseudouridine synthase activity
CVS42_RS12645	COG0346	lactoylglutathione lyase activity
CVS42_RS12655	COG1403	HNH endonuclease
CVS42_RS12660	COG4657	Part of a membrane complex involved in electron transport
CVS42_RS12665	COG2878	Part of a membrane complex involved in electron transport
CVS42_RS12675	COG4658	electron transport chain
CVS42_RS12680	COG4659	FMN binding
CVS42_RS12685	COG4660	Part of a membrane complex involved in electron transport
CVS42_RS12690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CVS42_RS12695	COG0346	lactoylglutathione lyase activity
CVS42_RS12730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CVS42_RS12735	COG0505	Belongs to the CarA family
CVS42_RS12740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CVS42_RS12755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CVS42_RS12760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CVS42_RS12765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS42_RS12770	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CVS42_RS12775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS42_RS12780	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CVS42_RS12810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CVS42_RS12815	COG0861	Integral membrane protein TerC family
CVS42_RS12830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS42_RS12835	COG0601	transmembrane transport
CVS42_RS12845	COG2095	MarC family integral membrane protein
CVS42_RS12850	COG1454	alcohol dehydrogenase
CVS42_RS12850	COG1012	belongs to the aldehyde dehydrogenase family
CVS42_RS12855	COG0217	transcriptional regulatory protein
CVS42_RS12860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CVS42_RS12870	COG1801	Protein of unknown function DUF72
CVS42_RS12875	COG4106	trans-aconitate 2-methyltransferase activity
CVS42_RS12880	COG0500	methyltransferase
CVS42_RS12920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CVS42_RS12935	COG1086	Polysaccharide biosynthesis protein
CVS42_RS12940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CVS42_RS12955	COG0367	asparagine synthase
CVS42_RS12960	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CVS42_RS12970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CVS42_RS12990	COG2226	methyltransferase
CVS42_RS13005	COG0438	transferase activity, transferring glycosyl groups
CVS42_RS13015	COG0562	UDP-galactopyranose mutase
CVS42_RS13020	COG1215	transferase activity, transferring glycosyl groups
CVS42_RS13035	COG0318	PFAM AMP-dependent synthetase and ligase
CVS42_RS13055	COG1083	cytidylyl-transferase
CVS42_RS13065	COG2089	acid synthase
CVS42_RS13085	COG4310	Domain of unknown function (DUF2172)
CVS42_RS13140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CVS42_RS13155	COG0301	tRNA thio-modification
CVS42_RS13155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVS42_RS13170	COG4953	penicillin-binding protein 1C
CVS42_RS13175	COG2373	Large extracellular alpha-helical protein
CVS42_RS13185	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS42_RS13190	COG3300	MHYT domain
CVS42_RS13190	COG5001	Diguanylate cyclase
CVS42_RS13195	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CVS42_RS13205	COG1252	NADH dehydrogenase
CVS42_RS13210	COG3150	esterase
CVS42_RS13215	COG2233	PERMEase
CVS42_RS13225	COG2354	Protein conserved in bacteria
CVS42_RS13235	COG0840	transmembrane signaling receptor activity
CVS42_RS13240	COG1301	dicarboxylic acid transport
CVS42_RS13255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CVS42_RS13270	COG0537	adenosine 5'-monophosphoramidase activity
CVS42_RS13305	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS42_RS13310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS42_RS13320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS42_RS13325	COG0287	Prephenate dehydrogenase
CVS42_RS13325	COG1605	Chorismate mutase
CVS42_RS13335	COG1199	ATP-dependent helicase activity
CVS42_RS13345	COG0123	including yeast histone deacetylase and acetoin utilization protein
CVS42_RS13350	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CVS42_RS13355	COG1785	Belongs to the alkaline phosphatase family
CVS42_RS13375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVS42_RS13380	COG2197	response regulator
CVS42_RS13390	COG2271	Major facilitator Superfamily
CVS42_RS13395	COG3300	MHYT domain
CVS42_RS13395	COG5001	Diguanylate cyclase
CVS42_RS13400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_RS13405	COG0765	amino acid transport
CVS42_RS13410	COG1126	abc transporter atp-binding protein
CVS42_RS13425	COG0531	amino acid
CVS42_RS13440	COG1253	flavin adenine dinucleotide binding
CVS42_RS13445	COG0704	Plays a role in the regulation of phosphate uptake
CVS42_RS13450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CVS42_RS13455	COG0581	inorganic phosphate transmembrane transporter activity
CVS42_RS13460	COG0573	inorganic phosphate transmembrane transporter activity
CVS42_RS13465	COG0590	tRNA wobble adenosine to inosine editing
CVS42_RS13475	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CVS42_RS13495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CVS42_RS13500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CVS42_RS13505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CVS42_RS13510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CVS42_RS13535	COG2716	regulation of RNA biosynthetic process
CVS42_RS13540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CVS42_RS13550	COG2239	Acts as a magnesium transporter
CVS42_RS13555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CVS42_RS13565	COG1705	Flagellar rod assembly protein muramidase FlgJ
CVS42_RS13565	COG3951	Flagellar rod assembly protein muramidase FlgJ
CVS42_RS13570	COG1706	bacterial-type flagellum-dependent cell motility
CVS42_RS13575	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CVS42_RS13585	COG4787	bacterial-type flagellum-dependent cell motility
CVS42_RS13595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CVS42_RS13605	COG1815	bacterial-type flagellum-dependent cell motility
CVS42_RS13610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CVS42_RS13615	COG0784	Response regulator, receiver
CVS42_RS13615	COG0835	chemotaxis
CVS42_RS13620	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CVS42_RS13635	COG0622	Phosphoesterase
CVS42_RS13640	COG4166	transmembrane transport
CVS42_RS13650	COG1187	pseudouridine synthase activity
CVS42_RS13655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVS42_RS13665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVS42_RS13670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CVS42_RS13675	COG1882	Formate acetyltransferase
CVS42_RS13680	COG1349	DNA-binding transcription factor activity
CVS42_RS13685	COG4166	transmembrane transport
CVS42_RS13710	COG1278	Cold shock
CVS42_RS13735	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CVS42_RS13735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVS42_RS13740	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_RS13745	COG3433	isochorismatase activity
CVS42_RS13745	COG1535	isochorismatase
CVS42_RS13750	COG1021	2,3-dihydroxybenzoate-AMP ligase
CVS42_RS13755	COG1169	isochorismate synthase
CVS42_RS13760	COG4771	TonB-dependent receptor
CVS42_RS13765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS42_RS13770	COG1609	Transcriptional regulator
CVS42_RS13775	COG0741	lytic transglycosylase activity
CVS42_RS13785	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CVS42_RS13805	COG2911	Protein conserved in bacteria
CVS42_RS13810	COG0729	surface antigen
CVS42_RS13820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS42_RS13835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS42_RS13845	COG4134	Bacterial extracellular solute-binding protein
CVS42_RS13855	COG4136	ATPase activity
CVS42_RS13860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CVS42_RS13865	COG2951	lytic endotransglycosylase activity
CVS42_RS13870	COG1846	Transcriptional regulator
CVS42_RS13880	COG0033	Phosphoglucomutase
CVS42_RS13885	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CVS42_RS13890	COG0596	Alpha beta hydrolase
CVS42_RS13905	COG0716	FMN binding
CVS42_RS13915	COG0735	belongs to the Fur family
CVS42_RS13920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS42_RS13930	COG2190	(PTS) system
CVS42_RS13930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS42_RS13930	COG1263	PTS System
CVS42_RS13935	COG0363	glucosamine-6-phosphate deaminase activity
CVS42_RS13940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CVS42_RS13945	COG1846	Transcriptional regulator
CVS42_RS13945	COG1940	carbohydrate kinase activity
CVS42_RS13955	COG2199	diguanylate cyclase activity
CVS42_RS13955	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVS42_RS13960	COG3275	phosphorelay sensor kinase activity
CVS42_RS13965	COG3279	Response regulator of the LytR AlgR family
CVS42_RS13970	COG1966	Carbon starvation protein
CVS42_RS13980	COG1566	PFAM secretion protein HlyD family protein
CVS42_RS13985	COG1061	Type III restriction enzyme res subunit
CVS42_RS13990	COG2027	D-alanyl-D-alanine carboxypeptidase
CVS42_RS13995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CVS42_RS14000	COG3021	interspecies interaction between organisms
CVS42_RS14010	COG1607	acyl-coa hydrolase
CVS42_RS14015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS42_RS14025	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CVS42_RS14025	COG0674	pyruvate-flavodoxin oxidoreductase activity
CVS42_RS14025	COG1013	pyruvate-flavodoxin oxidoreductase activity
CVS42_RS14025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CVS42_RS14040	COG3217	Mosc domain protein beta barrel domain protein
CVS42_RS14040	COG0633	Ferredoxin
CVS42_RS14040	COG3217	Mosc domain protein beta barrel domain protein
CVS42_RS14040	COG0633	Ferredoxin
CVS42_RS14050	COG0501	Belongs to the peptidase M48B family
CVS42_RS14055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CVS42_RS14060	COG2226	methyltransferase
CVS42_RS14060	COG1073	alpha beta
CVS42_RS14065	COG0156	8-amino-7-oxononanoate synthase activity
CVS42_RS14070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CVS42_RS14075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVS42_RS14090	COG0017	Asparaginyl-tRNA synthetase
CVS42_RS14100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CVS42_RS14110	COG1473	amidohydrolase
CVS42_RS14115	COG3069	C4-dicarboxylate transmembrane transporter activity
CVS42_RS14125	COG1393	Belongs to the ArsC family
CVS42_RS14130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS42_RS14135	COG1876	peptidase activity
CVS42_RS14145	COG3263	regulation of cellular component size
CVS42_RS14155	COG3263	regulation of cellular component size
CVS42_RS14160	COG1280	lysine exporter protein (LysE YggA)
CVS42_RS14190	COG0564	pseudouridine synthase activity
CVS42_RS14200	COG1454	alcohol dehydrogenase
CVS42_RS14205	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS42_RS14210	COG0702	epimerase
CVS42_RS14220	COG0095	Lipoate-protein ligase
CVS42_RS14230	COG1136	(ABC) transporter
CVS42_RS14230	COG0577	efflux transmembrane transporter activity
CVS42_RS14235	COG1136	(ABC) transporter
CVS42_RS14235	COG0577	efflux transmembrane transporter activity
CVS42_RS14240	COG0577	efflux transmembrane transporter activity
CVS42_RS14240	COG1136	(ABC) transporter
CVS42_RS14245	COG1566	PFAM secretion protein HlyD family protein
CVS42_RS14260	COG2391	methyltransferase activity
CVS42_RS14280	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS42_RS14290	COG1285	pathogenesis
CVS42_RS14320	COG0484	heat shock protein binding
CVS42_RS14325	COG0443	Heat shock 70 kDa protein
CVS42_RS14330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CVS42_RS14335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CVS42_RS14340	COG0497	DNA recombination
CVS42_RS14345	COG1227	inorganic diphosphatase activity
CVS42_RS14350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_RS14355	COG1136	(ABC) transporter
CVS42_RS14355	COG0577	efflux transmembrane transporter activity
CVS42_RS14375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CVS42_RS14385	COG0297	glycogen (starch) synthase activity
CVS42_RS14390	COG1216	Glycosyl transferase, family 2
CVS42_RS14390	COG0463	Glycosyl transferase, family 2
CVS42_RS14405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS42_RS14420	COG0529	Catalyzes the synthesis of activated sulfate
CVS42_RS14425	COG0471	metal ion transport
CVS42_RS14425	COG0490	domain, Protein
CVS42_RS14430	COG2895	sulfate adenylyltransferase (ATP) activity
CVS42_RS14440	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CVS42_RS14445	COG0463	Glycosyl transferase, family 2
CVS42_RS14475	COG1450	Type ii and iii secretion system protein
CVS42_RS14525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS42_RS14545	COG1091	dTDP-4-dehydrorhamnose reductase activity
CVS42_RS14560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_RS14565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_RS14570	COG1309	transcriptional regulator
CVS42_RS14585	COG1342	Belongs to the UPF0251 family
CVS42_RS14605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVS42_RS14620	COG1943	Transposase
CVS42_RS14635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CVS42_RS14640	COG0083	homoserine kinase activity
CVS42_RS14655	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CVS42_RS14660	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CVS42_RS14665	COG1946	Acyl-CoA thioesterase
CVS42_RS14675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CVS42_RS14685	COG0009	L-threonylcarbamoyladenylate synthase
CVS42_RS14695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CVS42_RS14700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVS42_RS14700	COG0512	Glutamine amidotransferase of anthranilate synthase
CVS42_RS14705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVS42_RS14710	COG0135	phosphoribosylanthranilate isomerase activity
CVS42_RS14710	COG0134	indole-3-glycerol-phosphate synthase activity
CVS42_RS14715	COG0133	tryptophan synthase activity
CVS42_RS14720	COG0159	tryptophan synthase activity
CVS42_RS14735	COG1988	membrane-bound metal-dependent
CVS42_RS14755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CVS42_RS14765	COG0798	PFAM Bile acid sodium symporter
CVS42_RS14795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS42_RS14805	COG0745	RESPONSE REGULATOR receiver
CVS42_RS14820	COG4988	ABC transporter
CVS42_RS14825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CVS42_RS14845	COG1720	tRNA m6t6A37 methyltransferase activity
CVS42_RS14850	COG3038	cytochrome b561
CVS42_RS14870	COG2862	Uncharacterized protein family, UPF0114
CVS42_RS14885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_RS14890	COG1917	Cupin 2, conserved barrel domain protein
CVS42_RS14890	COG1396	sequence-specific DNA binding
CVS42_RS14905	COG0531	amino acid
CVS42_RS14915	COG0531	amino acid
CVS42_RS14920	COG1283	sodium-dependent phosphate transmembrane transporter activity
CVS42_RS14930	COG0405	Gamma-glutamyltransferase
CVS42_RS14935	COG2974	May be involved in recombination
CVS42_RS14945	COG0420	3'-5' exonuclease activity
CVS42_RS14950	COG0419	ATPase involved in DNA repair
CVS42_RS14955	COG3384	dioxygenase
CVS42_RS14965	COG0469	pyruvate kinase activity
CVS42_RS14970	COG1196	nuclear chromosome segregation
CVS42_RS14970	COG3264	Mechanosensitive ion channel
CVS42_RS14980	COG3590	peptidase
CVS42_RS14985	COG3706	GGDEF domain
CVS42_RS14990	COG2190	(PTS) system
CVS42_RS15000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_RS15005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CVS42_RS15010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVS42_RS15025	COG2770	Histidine kinase
CVS42_RS15025	COG3437	response regulator, receiver
CVS42_RS15030	COG3409	Peptidoglycan-binding domain 1 protein
CVS42_RS15030	COG3267	Type II secretory pathway component ExeA
CVS42_RS15040	COG3031	protein transport across the cell outer membrane
CVS42_RS15050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS42_RS15055	COG1459	type II secretion system
CVS42_RS15060	COG2165	general secretion pathway protein
CVS42_RS15070	COG2165	general secretion pathway protein
CVS42_RS15075	COG4795	General secretion pathway protein
CVS42_RS15080	COG3156	type II secretion system protein K
CVS42_RS15090	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CVS42_RS15100	COG0582	viral genome integration into host DNA
CVS42_RS15170	COG3501	Rhs element vgr protein
CVS42_RS15185	COG2916	Histone family protein nucleoid-structuring protein H-NS
CVS42_RS15195	COG4983	Phage plasmid primase, P4 family domain protein
CVS42_RS15245	COG2003	Belongs to the UPF0758 family
CVS42_RS15295	COG2003	Belongs to the UPF0758 family
CVS42_RS15310	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CVS42_RS15320	COG0670	Belongs to the BI1 family
CVS42_RS15325	COG1289	transmembrane transporter activity
CVS42_RS15330	COG2920	part of a sulfur-relay system
CVS42_RS15335	COG0673	inositol 2-dehydrogenase activity
CVS42_RS15340	COG0583	DNA-binding transcription factor activity
CVS42_RS15390	COG1032	radical SAM domain protein
CVS42_RS15400	COG1566	PFAM secretion protein HlyD family protein
CVS42_RS15405	COG3706	GGDEF domain
CVS42_RS15410	COG1752	Esterase of the alpha-beta hydrolase superfamily
CVS42_RS15415	COG0531	amino acid
CVS42_RS15440	COG0281	malic enzyme
CVS42_RS15450	COG0534	Mate efflux family protein
CVS42_RS15465	COG2233	PERMEase
CVS42_RS15470	COG0095	Lipoate-protein ligase
CVS42_RS15475	COG1115	amino acid carrier protein
CVS42_RS15480	COG0019	diaminopimelate decarboxylase activity
CVS42_RS15490	COG0678	peroxiredoxin activity
CVS42_RS15515	COG0545	Peptidyl-prolyl cis-trans isomerase
CVS42_RS15520	COG3142	Participates in the control of copper homeostasis
CVS42_RS15545	COG5002	protein histidine kinase activity
CVS42_RS15550	COG0745	RESPONSE REGULATOR receiver
CVS42_RS15555	COG0346	lactoylglutathione lyase activity
CVS42_RS15560	COG3284	Transcriptional regulator
CVS42_RS15575	COG0697	spore germination
CVS42_RS15580	COG4565	transcriptional regulatory protein
CVS42_RS15585	COG3290	protein histidine kinase activity
CVS42_RS15590	COG0281	malic enzyme
CVS42_RS15605	COG1846	Transcriptional regulator
CVS42_RS15610	COG1566	PFAM secretion protein HlyD family protein
CVS42_RS15640	COG0602	queuosine metabolic process
CVS42_RS15645	COG1328	CTP reductase activity
CVS42_RS15655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CVS42_RS15660	COG3115	cell septum assembly
CVS42_RS15665	COG1196	nuclear chromosome segregation
CVS42_RS15675	COG2860	membrane
CVS42_RS15685	COG3108	Peptidase M15
CVS42_RS15690	COG2989	Protein conserved in bacteria
CVS42_RS15705	COG0463	Glycosyl transferase, family 2
CVS42_RS15720	COG0366	Alpha amylase catalytic
CVS42_RS15755	COG2199	diguanylate cyclase activity
CVS42_RS15755	COG2203	Gaf domain
CVS42_RS15765	COG3590	peptidase
CVS42_RS15775	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CVS42_RS15780	COG1982	Orn Lys Arg decarboxylase major
CVS42_RS15785	COG0531	amino acid
CVS42_RS15790	COG3710	Transcriptional regulator
CVS42_RS15800	COG0531	amino acid
CVS42_RS15820	COG0814	amino acid
CVS42_RS15850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CVS42_RS15855	COG0739	heme binding
CVS42_RS15860	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CVS42_RS15870	COG0251	oxidation-reduction process
CVS42_RS15885	COG0583	DNA-binding transcription factor activity
CVS42_RS15890	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_RS15890	COG0604	alcohol dehydrogenase
CVS42_RS15890	COG3321	synthase
CVS42_RS15900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CVS42_RS15910	COG3091	SprT-like family
CVS42_RS15920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CVS42_RS15925	COG0189	ligase activity
CVS42_RS15930	COG1678	Uncharacterized ACR, COG1678
CVS42_RS15935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CVS42_RS15940	COG3104	oligopeptide transport
CVS42_RS15955	COG0714	Associated with various cellular activities
CVS42_RS15970	COG1115	amino acid carrier protein
CVS42_RS15975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVS42_RS15985	COG0825	malonyl-CoA metabolic process
CVS42_RS15995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CVS42_RS16000	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS42_RS16005	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS42_RS16010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVS42_RS16015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS42_RS16030	COG0750	zinc metalloprotease
CVS42_RS16035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CVS42_RS16040	COG0575	Belongs to the CDS family
CVS42_RS16045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CVS42_RS16050	COG0233	cytoplasmic translational termination
CVS42_RS16055	COG0528	UMP kinase activity
CVS42_RS16060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CVS42_RS16065	COG0052	Belongs to the universal ribosomal protein uS2 family
CVS42_RS16070	COG0024	Methionine aminopeptidase
CVS42_RS16075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CVS42_RS16080	COG2171	N-acyltransferase activity
CVS42_RS16090	COG1263	PTS System
CVS42_RS16090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS42_RS16110	COG0564	pseudouridine synthase activity
CVS42_RS16115	COG3098	single-species biofilm formation
CVS42_RS16140	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CVS42_RS16150	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVS42_RS16150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVS42_RS16165	COG1611	Belongs to the LOG family
CVS42_RS16170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVS42_RS16175	COG0473	3-isopropylmalate dehydrogenase activity
CVS42_RS16185	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CVS42_RS16190	COG2363	Small membrane protein
CVS42_RS16200	COG0583	DNA-binding transcription factor activity
CVS42_RS16205	COG0840	transmembrane signaling receptor activity
CVS42_RS16210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CVS42_RS16225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CVS42_RS16230	COG1666	GTP binding
CVS42_RS16240	COG2211	Major facilitator Superfamily
CVS42_RS16245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CVS42_RS16255	COG2813	Specifically methylates the guanine in position
CVS42_RS16260	COG0271	Belongs to the BolA IbaG family
CVS42_RS16265	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CVS42_RS16270	COG1805	sodium ion transport
CVS42_RS16275	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CVS42_RS16280	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CVS42_RS16285	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CVS42_RS16290	COG2871	sodium ion transport
CVS42_RS16295	COG1477	protein flavinylation
CVS42_RS16325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS42_RS16340	COG0300	oxidoreductase activity
CVS42_RS16350	COG0415	Belongs to the DNA photolyase family
CVS42_RS16355	COG0789	Transcriptional regulator
CVS42_RS16360	COG3272	Protein of unknown function (DUF1722)
CVS42_RS16390	COG0077	Prephenate dehydratase
CVS42_RS16390	COG1605	Chorismate mutase
CVS42_RS16440	COG0697	spore germination
CVS42_RS16445	COG0840	transmembrane signaling receptor activity
CVS42_RS16455	COG0300	oxidoreductase activity
CVS42_RS16480	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CVS42_RS16520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVS42_RS16525	COG0826	peptidase U32
CVS42_RS16530	COG1280	lysine exporter protein (LysE YggA)
CVS42_RS16540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVS42_RS16550	COG0745	RESPONSE REGULATOR receiver
CVS42_RS16560	COG2198	Histidine kinase
CVS42_RS16560	COG0643	Histidine kinase
CVS42_RS16570	COG0835	chemotaxis
CVS42_RS16575	COG0840	transmembrane signaling receptor activity
CVS42_RS16585	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CVS42_RS16590	COG2201	protein-glutamate methylesterase activity
CVS42_RS16595	COG1185	polyribonucleotide nucleotidyltransferase activity
CVS42_RS16600	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CVS42_RS16605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CVS42_RS16610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CVS42_RS16615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CVS42_RS16620	COG0195	Participates in both transcription termination and antitermination
CVS42_RS16625	COG0779	Required for maturation of 30S ribosomal subunits
CVS42_RS16640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CVS42_RS16645	COG0149	triose-phosphate isomerase activity
CVS42_RS16650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVS42_RS16655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CVS42_RS16665	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CVS42_RS16670	COG1534	Rna-binding protein
CVS42_RS16685	COG1360	Flagellar Motor Protein
CVS42_RS16690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CVS42_RS16695	COG1722	exodeoxyribonuclease VII activity
CVS42_RS16700	COG0142	geranyltranstransferase activity
CVS42_RS16705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CVS42_RS16715	COG0601	transmembrane transport
CVS42_RS16730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CVS42_RS16735	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CVS42_RS16740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS42_RS16745	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CVS42_RS16765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVS42_RS16765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVS42_RS16770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CVS42_RS16780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVS42_RS16790	COG0784	Response regulator, receiver
CVS42_RS16790	COG2198	Histidine kinase
CVS42_RS16790	COG2205	protein histidine kinase activity
CVS42_RS16795	COG1879	ABC-type sugar transport system periplasmic component
CVS42_RS16805	COG0745	RESPONSE REGULATOR receiver
CVS42_RS16810	COG3005	denitrification pathway
CVS42_RS16820	COG3381	protein complex oligomerization
CVS42_RS16840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS42_RS16845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CVS42_RS16850	COG0511	ligase activity, forming carbon-carbon bonds
CVS42_RS16855	COG0439	Biotin carboxylase
CVS42_RS16865	COG4145	pantothenate transmembrane transporter activity
CVS42_RS16870	COG1263	PTS System
CVS42_RS16870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS42_RS16870	COG2190	(PTS) system
CVS42_RS16875	COG0583	DNA-binding transcription factor activity
CVS42_RS16880	COG0604	alcohol dehydrogenase
CVS42_RS16885	COG2264	protein methyltransferase activity
CVS42_RS16895	COG0778	Nitroreductase
CVS42_RS16900	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS42_RS16900	COG1902	pentaerythritol trinitrate reductase activity
CVS42_RS16905	COG0616	signal peptide processing
CVS42_RS16925	COG0848	biopolymer transport protein
CVS42_RS16930	COG0811	peptide transport
CVS42_RS16935	COG0811	peptide transport
CVS42_RS16950	COG4174	ABC transporter (Permease)
CVS42_RS16955	COG4239	(ABC) transporter, permease
CVS42_RS16965	COG0444	Belongs to the ABC transporter superfamily
CVS42_RS16970	COG4608	Belongs to the ABC transporter superfamily
CVS42_RS16990	COG3416	Protein conserved in bacteria
CVS42_RS17000	COG0741	lytic transglycosylase activity
CVS42_RS17015	COG0488	(ABC) transporter
CVS42_RS17025	COG2252	PERMEase
CVS42_RS17030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS42_RS17035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS42_RS17040	COG0840	transmembrane signaling receptor activity
CVS42_RS17050	COG1278	Cold shock
CVS42_RS17090	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CVS42_RS17095	COG1162	GTPase activity
CVS42_RS17100	COG0688	phosphatidylethanolamine metabolic process
CVS42_RS17105	COG4628	conserved protein (DUF2132)
CVS42_RS17120	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CVS42_RS17135	COG1073	alpha beta
CVS42_RS17140	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CVS42_RS17150	COG2195	Cleaves the N-terminal amino acid of tripeptides
CVS42_RS17155	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CVS42_RS17160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVS42_RS17165	COG3178	'Phosphotransferase
CVS42_RS17170	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CVS42_RS17175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS42_RS17180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CVS42_RS17185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CVS42_RS17190	COG2967	ApaG domain
CVS42_RS17195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVS42_RS17210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS42_RS17220	COG3314	Sporulation integral membrane protein YlbJ
CVS42_RS17225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CVS42_RS17230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CVS42_RS17235	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CVS42_RS17240	COG0142	geranyltranstransferase activity
CVS42_RS17245	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CVS42_RS17250	COG0330	HflC and HflK could
CVS42_RS17255	COG0330	HflC and HflK could
CVS42_RS17260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CVS42_RS17265	COG1923	regulation of RNA biosynthetic process
CVS42_RS17270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CVS42_RS17275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CVS42_RS17285	COG0802	atpase or kinase
CVS42_RS17290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CVS42_RS17290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CVS42_RS17310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CVS42_RS17315	COG2011	ABC-type metal ion transport system permease component
CVS42_RS17320	COG1464	Belongs to the NlpA lipoprotein family
CVS42_RS17330	COG0840	transmembrane signaling receptor activity
CVS42_RS17345	COG0784	Response regulator, receiver
CVS42_RS17345	COG5002	protein histidine kinase activity
CVS42_RS17345	COG2198	Histidine kinase
CVS42_RS17380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CVS42_RS17385	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CVS42_RS17390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS42_RS17395	COG2716	regulation of RNA biosynthetic process
CVS42_RS17400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CVS42_RS17405	COG3013	Belongs to the UPF0304 family
CVS42_RS17415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CVS42_RS17420	COG0280	phosphate acetyltransferase
CVS42_RS17420	COG0857	belongs to the CobB CobQ family
CVS42_RS17425	COG1555	photosystem II stabilization
CVS42_RS17430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CVS42_RS17435	COG3104	oligopeptide transport
CVS42_RS17440	COG0745	RESPONSE REGULATOR receiver
CVS42_RS17470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_RS17485	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CVS42_RS17520	COG0440	acetolactate synthase activity
CVS42_RS17525	COG0028	Belongs to the TPP enzyme family
CVS42_RS17550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS42_RS17555	COG0473	3-isopropylmalate dehydrogenase activity
CVS42_RS17560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CVS42_RS17565	COG0066	3-isopropylmalate dehydratase activity
CVS42_RS17580	COG4143	(ABC) transporter
CVS42_RS17590	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CVS42_RS17595	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CVS42_RS17645	COG0459	protein refolding
CVS42_RS17650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CVS42_RS17655	COG0534	Mate efflux family protein
CVS42_RS17660	COG3030	protein affecting phage T7 exclusion by the F plasmid
CVS42_RS17665	COG1027	Aspartate ammonia-lyase
CVS42_RS17670	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CVS42_RS17675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CVS42_RS17680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CVS42_RS17685	COG1610	YqeY-like protein
CVS42_RS17690	COG0358	DNA primase activity
CVS42_RS17695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CVS42_RS17765	COG0151	Belongs to the GarS family
CVS42_RS17770	COG0138	bifunctional purine biosynthesis protein purh
CVS42_RS17810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS42_RS17815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS42_RS17825	COG0583	DNA-binding transcription factor activity
CVS42_RS17830	COG0477	Major facilitator Superfamily
CVS42_RS17845	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_RS17855	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CVS42_RS17870	COG0456	acetyltransferase
CVS42_RS17880	COG1022	Amp-dependent synthetase and ligase
CVS42_RS17890	COG2918	glutathione biosynthetic process
CVS42_RS17895	COG0612	Peptidase, M16
CVS42_RS17900	COG1238	metal cluster binding
CVS42_RS17905	COG4221	oxidoreductase activity
CVS42_RS17905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVS42_RS17905	COG3321	synthase
CVS42_RS17905	COG0604	alcohol dehydrogenase
CVS42_RS17930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS42_RS17935	COG0359	binds to the 23S rRNA
CVS42_RS17940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CVS42_RS17945	COG0360	Binds together with S18 to 16S ribosomal RNA
CVS42_RS17950	COG1914	H( )-stimulated, divalent metal cation uptake system
CVS42_RS17955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVS42_RS17965	COG0776	regulation of translation
CVS42_RS17980	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CVS42_RS17995	COG0560	Phosphoserine phosphatase
CVS42_RS18010	COG0813	purine-nucleoside phosphorylase activity
CVS42_RS18015	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CVS42_RS18020	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CVS42_RS18025	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CVS42_RS18035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CVS42_RS18040	COG0084	hydrolase, TatD family'
CVS42_RS18045	COG2165	general secretion pathway protein
CVS42_RS18055	COG1854	S-ribosylhomocysteine lyase activity
CVS42_RS18070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CVS42_RS18070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVS42_RS18130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CVS42_RS18135	COG1047	Peptidyl-prolyl cis-trans
CVS42_RS18140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CVS42_RS18145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CVS42_RS18150	COG0196	riboflavin kinase activity
CVS42_RS18155	COG0728	peptidoglycan biosynthetic process
CVS42_RS18160	COG0268	Binds directly to 16S ribosomal RNA
CVS42_RS18165	COG0640	Transcriptional regulator
CVS42_RS18170	COG0583	DNA-binding transcription factor activity
CVS42_RS18180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVS42_RS18185	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CVS42_RS18190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CVS42_RS18195	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CVS42_RS18200	COG1051	belongs to the nudix hydrolase family
CVS42_RS18205	COG3066	DNA modification
CVS42_RS18215	COG0335	large ribosomal subunit rRNA binding
CVS42_RS18220	COG0336	Belongs to the RNA methyltransferase TrmD family
CVS42_RS18225	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CVS42_RS18230	COG0228	four-way junction DNA binding
CVS42_RS18235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CVS42_RS18240	COG4137	Cytochrome C assembly protein
CVS42_RS18245	COG4536	flavin adenine dinucleotide binding
CVS42_RS18255	COG1017	nitric oxide dioxygenase activity
CVS42_RS18255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS42_RS18260	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CVS42_RS18265	COG0039	L-malate dehydrogenase activity
CVS42_RS18270	COG4160	amino acid transport
CVS42_RS18275	COG4215	(ABC) transporter
CVS42_RS18280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_RS18285	COG1126	abc transporter atp-binding protein
CVS42_RS18290	COG1438	arginine binding
CVS42_RS18295	COG2837	iron assimilation
CVS42_RS18300	COG3842	ATPase activity
CVS42_RS18310	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS42_RS18315	COG0347	Belongs to the P(II) protein family
CVS42_RS18335	COG3022	response to hydroperoxide
CVS42_RS18350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CVS42_RS18355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CVS42_RS18360	COG0762	integral membrane protein
CVS42_RS18365	COG1872	DUF167
CVS42_RS18375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CVS42_RS18380	COG0583	DNA-binding transcription factor activity
CVS42_RS18395	COG1929	Belongs to the glycerate kinase type-1 family
CVS42_RS18400	COG2610	gluconate transmembrane transporter activity
CVS42_RS18405	COG3835	regulator
CVS42_RS18410	COG3112	Uncharacterised protein family (UPF0231)
CVS42_RS18430	COG3568	Endonuclease Exonuclease Phosphatase
CVS42_RS18440	COG0513	Belongs to the DEAD box helicase family
CVS42_RS18480	COG1448	Aminotransferase
CVS42_RS18495	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CVS42_RS18500	COG1328	CTP reductase activity
CVS42_RS18515	COG0543	2 iron, 2 sulfur cluster binding
CVS42_RS18515	COG0633	Ferredoxin
CVS42_RS18530	COG1215	transferase activity, transferring glycosyl groups
CVS42_RS18535	COG0726	polysaccharide deacetylase
CVS42_RS18535	COG1649	PFAM Uncharacterised BCR, COG1649
CVS42_RS18550	COG4783	chaperone-mediated protein folding
CVS42_RS18555	COG1215	transferase activity, transferring glycosyl groups
CVS42_RS18560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CVS42_RS18570	COG0840	transmembrane signaling receptor activity
CVS42_RS18575	COG3397	chitin binding
CVS42_RS18580	COG0583	DNA-binding transcription factor activity
CVS42_RS18585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CVS42_RS18590	COG4208	sulfate ABC transporter
CVS42_RS18595	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CVS42_RS18605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CVS42_RS18610	COG3174	membrane
CVS42_RS18615	COG0110	maltose O-acetyltransferase activity
CVS42_RS18630	COG1011	Hydrolase
CVS42_RS18635	COG0494	nUDIX hydrolase
CVS42_RS18640	COG1218	3'(2'),5'-bisphosphate nucleotidase
CVS42_RS18645	COG0814	amino acid
CVS42_RS18650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS42_RS18665	COG0626	cystathionine gamma-synthase activity
CVS42_RS18670	COG0460	homoserine dehydrogenase
CVS42_RS18670	COG0527	aspartate kinase activity
CVS42_RS18680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS42_RS18685	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS42_RS18690	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CVS42_RS18695	COG2186	Transcriptional regulator
CVS42_RS18725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS42_RS18730	COG1459	type II secretion system
CVS42_RS18745	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CVS42_RS18750	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CVS42_RS18755	COG0494	nUDIX hydrolase
CVS42_RS18760	COG0653	protein targeting
CVS42_RS18770	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CVS42_RS18775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CVS42_RS18780	COG0849	cell division
CVS42_RS18790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVS42_RS18795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CVS42_RS18800	COG0772	Belongs to the SEDS family
CVS42_RS18805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CVS42_RS18810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS42_RS18815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CVS42_RS18825	COG0768	penicillin binding
CVS42_RS18830	COG3116	cell division
CVS42_RS18835	COG0275	rRNA processing
CVS42_RS18840	COG2001	Belongs to the MraZ family
CVS42_RS18850	COG0741	lytic transglycosylase activity
CVS42_RS18850	COG1388	LysM domain
CVS42_RS18865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CVS42_RS18870	COG1191	sigma factor activity
CVS42_RS18895	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CVS42_RS18900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CVS42_RS18915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CVS42_RS18920	COG4786	Flagellar basal body rod
CVS42_RS18920	COG1256	bacterial-type flagellum assembly
CVS42_RS18930	COG1706	bacterial-type flagellum-dependent cell motility
CVS42_RS18935	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CVS42_RS18940	COG4786	Flagellar basal body rod
CVS42_RS18945	COG4787	bacterial-type flagellum-dependent cell motility
CVS42_RS18965	COG1815	bacterial-type flagellum-dependent cell motility
CVS42_RS19000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CVS42_RS19010	COG1677	Flagellar hook-basal body complex protein FliE
CVS42_RS19035	COG1987	bacterial-type flagellum assembly
CVS42_RS19060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CVS42_RS19065	COG3107	peptidoglycan biosynthetic process
CVS42_RS19070	COG0792	nuclease activity
CVS42_RS19075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CVS42_RS19080	COG2823	Periplasmic or secreted lipoprotein
CVS42_RS19085	COG2969	positive regulation of protein catabolic process
CVS42_RS19090	COG0625	glutathione transferase activity
CVS42_RS19095	COG2857	Cytochrome c1
CVS42_RS19100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CVS42_RS19105	COG0723	plastoquinol--plastocyanin reductase activity
CVS42_RS19110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CVS42_RS19115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CVS42_RS19120	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CVS42_RS19130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS42_RS19135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS42_RS19165	COG3964	amidohydrolase
CVS42_RS19180	COG3711	transcriptional antiterminator
CVS42_RS19180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_RS19185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_RS19190	COG1660	Displays ATPase and GTPase activities
CVS42_RS19195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_RS19210	COG1137	ATPase activity
CVS42_RS19215	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CVS42_RS19220	COG3117	lipopolysaccharide transmembrane transporter activity
CVS42_RS19225	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CVS42_RS19230	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CVS42_RS19230	COG0517	IMP dehydrogenase activity
CVS42_RS19235	COG1127	ABC transporter
CVS42_RS19240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CVS42_RS19245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CVS42_RS19250	COG2854	intermembrane phospholipid transfer
CVS42_RS19260	COG5007	Belongs to the BolA IbaG family
CVS42_RS19265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CVS42_RS19270	COG0312	modulator of DNA gyrase
CVS42_RS19275	COG3028	Belongs to the UPF0307 family
CVS42_RS19280	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CVS42_RS19300	COG1011	Hydrolase
CVS42_RS19315	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CVS42_RS19320	COG0019	diaminopimelate decarboxylase activity
CVS42_RS19330	COG1965	Belongs to the frataxin family
CVS42_RS19335	COG0400	carboxylic ester hydrolase activity
CVS42_RS19340	COG3072	Adenylate cyclase
CVS42_RS19345	COG0181	hydroxymethylbilane synthase activity
CVS42_RS19355	COG2959	enzyme of heme biosynthesis
CVS42_RS19370	COG1494	fructose-1,6-bisphosphatase
CVS42_RS19420	COG3501	Rhs element vgr protein
CVS42_RS19430	COG3209	COG3209 Rhs family protein
CVS42_RS19430	COG4104	PAAR repeat-containing protein
CVS42_RS19440	COG4104	PAAR repeat-containing protein
CVS42_RS19440	COG3209	COG3209 Rhs family protein
CVS42_RS19470	COG4584	PFAM Integrase catalytic
CVS42_RS19475	COG1484	DNA-dependent DNA replication
CVS42_RS19490	COG0850	regulation of cytokinetic process
CVS42_RS19495	COG3100	YcgL domain-containing protein
CVS42_RS19505	COG0306	phosphate transporter
CVS42_RS19510	COG1392	Phosphate transport regulator
CVS42_RS19520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS42_RS19525	COG2813	Specifically methylates the guanine in position
CVS42_RS19530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CVS42_RS19535	COG0297	glycogen (starch) synthase activity
CVS42_RS19575	COG1757	Na H antiporter
CVS42_RS19580	COG0316	Belongs to the HesB IscA family
CVS42_RS19590	COG0038	chloride channel
CVS42_RS19595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CVS42_RS19615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS42_RS19615	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVS42_RS19630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CVS42_RS19635	COG0564	pseudouridine synthase activity
CVS42_RS19650	COG0110	maltose O-acetyltransferase activity
CVS42_RS19655	COG0366	Alpha amylase catalytic
CVS42_RS19660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS42_RS19660	COG1263	PTS System
CVS42_RS19680	COG0252	asparaginase activity
CVS42_RS19685	COG1253	flavin adenine dinucleotide binding
CVS42_RS19690	COG0586	Pfam SNARE associated Golgi protein
CVS42_RS19695	COG1686	Belongs to the peptidase S11 family
CVS42_RS19730	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CVS42_RS19735	COG0527	aspartate kinase activity
CVS42_RS19740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVS42_RS19750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CVS42_RS19755	COG1546	Belongs to the CinA family
CVS42_RS19760	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CVS42_RS19765	COG4667	esterase of the alpha-beta hydrolase superfamily
CVS42_RS19775	COG1346	cytolysis
CVS42_RS19780	COG1380	Effector of murein hydrolase LrgA
CVS42_RS19785	COG0583	DNA-binding transcription factor activity
CVS42_RS19795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CVS42_RS19840	COG1396	sequence-specific DNA binding
CVS42_RS19845	COG3135	benzoate transporter
CVS42_RS19870	COG0840	transmembrane signaling receptor activity
CVS42_RS19875	COG3047	cAMP biosynthetic process
CVS42_RS19880	COG2199	diguanylate cyclase activity
CVS42_RS19885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CVS42_RS19905	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CVS42_RS19915	COG1278	Cold shock
CVS42_RS19920	COG2252	PERMEase
CVS42_RS19925	COG2376	Dihydroxyacetone kinase
CVS42_RS19930	COG1461	Dihydroxyacetone kinase
CVS42_RS19935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CVS42_RS19935	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CVS42_RS19935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_RS19945	COG3284	Transcriptional regulator
CVS42_RS19960	COG0628	permease
CVS42_RS19980	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CVS42_RS19985	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CVS42_RS20005	COG0456	acetyltransferase
CVS42_RS20010	COG3133	Outer membrane lipoprotein
CVS42_RS20015	COG0004	ammonium transporteR
CVS42_RS20030	COG3932	Exopolysaccharide synthesis, ExoD
CVS42_RS20035	COG0814	amino acid
CVS42_RS20040	COG3706	GGDEF domain
CVS42_RS20050	COG0110	maltose O-acetyltransferase activity
CVS42_RS20070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CVS42_RS20075	COG2022	thiamine diphosphate biosynthetic process
CVS42_RS20085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CVS42_RS20090	COG0352	thiamine-phosphate diphosphorylase activity
CVS42_RS20095	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CVS42_RS20100	COG0754	glutathionylspermidine amidase activity
CVS42_RS20110	COG3766	membrane
CVS42_RS20130	COG0745	RESPONSE REGULATOR receiver
CVS42_RS20135	COG0642	Histidine kinase
CVS42_RS20140	COG0189	ligase activity
CVS42_RS20185	COG0477	Major facilitator Superfamily
CVS42_RS20200	COG0312	modulator of DNA gyrase
CVS42_RS20205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVS42_RS20220	COG3164	Protein of unknown function
CVS42_RS20225	COG1530	ribonuclease E activity
CVS42_RS20230	COG0424	maF-like protein
CVS42_RS20235	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CVS42_RS20240	COG1792	Involved in formation and maintenance of cell shape
CVS42_RS20245	COG1077	Cell shape determining protein MreB Mrl
CVS42_RS20270	COG4968	Prepilin-type N-terminal cleavage methylation domain
CVS42_RS20275	COG2165	general secretion pathway protein
CVS42_RS20290	COG1459	type II secretion system
CVS42_RS20295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS42_RS20340	COG2199	diguanylate cyclase activity
CVS42_RS20340	COG2200	EAL domain
CVS42_RS20345	COG2200	EAL domain
CVS42_RS20350	COG0387	Pfam Sodium calcium exchanger
CVS42_RS20355	COG2986	histidine ammonia-lyase
CVS42_RS20360	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CVS42_RS20365	COG0010	Belongs to the arginase family
CVS42_RS20370	COG1228	amidohydrolase
CVS42_RS20375	COG2188	Transcriptional regulator
CVS42_RS20380	COG0288	reversible hydration of carbon dioxide
CVS42_RS20390	COG2177	Part of the ABC transporter FtsEX involved in
CVS42_RS20395	COG2884	Cell division ATP-binding protein ftsE
CVS42_RS20400	COG0552	protein localization to endoplasmic reticulum
CVS42_RS20405	COG0742	ribosomal rna small subunit methyltransferase
CVS42_RS20430	COG2249	NAD(P)H dehydrogenase (quinone) activity
CVS42_RS20435	COG0583	DNA-binding transcription factor activity
CVS42_RS20440	COG4221	oxidoreductase activity
CVS42_RS20455	COG1770	oligopeptidase
CVS42_RS20470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS42_RS20475	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CVS42_RS20485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS42_RS20495	COG2095	MarC family integral membrane protein
CVS42_RS20505	COG1301	dicarboxylic acid transport
CVS42_RS20530	COG3714	YhhN family
CVS42_RS20580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CVS42_RS20585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVS42_RS20590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CVS42_RS20595	COG0049	tRNA binding
CVS42_RS20600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CVS42_RS20605	COG2168	tRNA wobble position uridine thiolation
CVS42_RS20610	COG2923	Belongs to the DsrF TusC family
CVS42_RS20615	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CVS42_RS20625	COG2964	Protein conserved in bacteria
CVS42_RS20630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CVS42_RS20635	COG0085	RNA polymerase activity
CVS42_RS20640	COG0222	ribosome binding
CVS42_RS20645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CVS42_RS20650	COG0081	regulation of translation
CVS42_RS20655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CVS42_RS20660	COG0250	Participates in transcription elongation, termination and antitermination
CVS42_RS20675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVS42_RS20700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CVS42_RS20705	COG0569	domain protein
CVS42_RS20710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CVS42_RS20740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_RS20740	COG4191	Histidine kinase
CVS42_RS20745	COG3005	denitrification pathway
CVS42_RS20750	COG0243	molybdopterin cofactor binding
CVS42_RS20800	COG2204	response regulator
CVS42_RS20810	COG2205	protein histidine kinase activity
CVS42_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_RS20830	COG0517	IMP dehydrogenase activity
CVS42_RS20830	COG0516	GMP reductase activity
CVS42_RS20835	COG5413	integral membrane protein
CVS42_RS20845	COG1522	sequence-specific DNA binding
CVS42_RS20850	COG2502	aspartate--ammonia ligase
CVS42_RS20855	COG0542	response to heat
CVS42_RS20865	COG0564	pseudouridine synthase activity
CVS42_RS20870	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS42_RS20875	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS42_RS20885	COG3681	Belongs to the UPF0597 family
CVS42_RS20890	COG2964	Protein conserved in bacteria
CVS42_RS20900	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CVS42_RS20905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CVS42_RS20910	COG1979	alcohol dehydrogenase
CVS42_RS20915	COG2207	Transcriptional regulator
CVS42_RS20935	COG0583	DNA-binding transcription factor activity
CVS42_RS20950	COG0540	Belongs to the ATCase OTCase family
CVS42_RS20955	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CVS42_RS20960	COG1438	arginine binding
CVS42_RS20965	COG1288	antiporter activity
CVS42_RS20970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CVS42_RS20995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVS42_RS21005	COG3078	GTPase activator activity
CVS42_RS21020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CVS42_RS21030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CVS42_RS21035	COG0408	coproporphyrinogen oxidase activity
CVS42_RS21040	COG0009	L-threonylcarbamoyladenylate synthase
CVS42_RS21050	COG0551	DNA topoisomerase type I activity
CVS42_RS21055	COG2922	Belongs to the Smg family
CVS42_RS21060	COG0758	DNA mediated transformation
CVS42_RS21065	COG1652	LysM domain
CVS42_RS21070	COG0242	peptide deformylase activity
CVS42_RS21075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CVS42_RS21080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS42_RS21080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS42_RS21085	COG0569	domain protein
CVS42_RS21090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CVS42_RS21095	COG1217	gtp-binding protein TYPA
CVS42_RS21100	COG0174	glutamine synthetase
CVS42_RS21115	COG2204	response regulator
CVS42_RS21120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CVS42_RS21125	COG1322	Protein conserved in bacteria
CVS42_RS21145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS42_RS21150	COG0583	DNA-binding transcription factor activity
CVS42_RS21155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVS42_RS21155	COG0519	Catalyzes the synthesis of GMP from XMP
CVS42_RS21165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVS42_RS21170	COG1396	sequence-specific DNA binding
CVS42_RS21175	COG1012	belongs to the aldehyde dehydrogenase family
CVS42_RS21185	COG2962	Rard protein
CVS42_RS21195	COG2391	methyltransferase activity
CVS42_RS21205	COG1309	transcriptional regulator
CVS42_RS21230	COG1401	restriction endodeoxyribonuclease activity
CVS42_RS21240	COG0129	dihydroxy-acid dehydratase activity
CVS42_RS21250	COG3978	acetolactate synthase activity
CVS42_RS21265	COG0606	chelatase, subunit chli
CVS42_RS21270	COG0204	Acyl-transferase
CVS42_RS21275	COG0204	Acyl-transferase
CVS42_RS21280	COG1683	Conserved Protein
CVS42_RS21290	COG1335	isochorismatase
CVS42_RS21300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS42_RS21305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CVS42_RS21315	COG3084	Protein conserved in bacteria
CVS42_RS21320	COG3706	GGDEF domain
CVS42_RS21320	COG5001	Diguanylate cyclase
CVS42_RS21320	COG2203	Gaf domain
CVS42_RS21320	COG4251	negative regulation of phosphorylation
CVS42_RS21335	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CVS42_RS21340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CVS42_RS21345	COG1561	YicC-like family, N-terminal region
CVS42_RS21350	COG0583	DNA-binding transcription factor activity
CVS42_RS21370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CVS42_RS21375	COG0385	Bile acid
CVS42_RS21380	COG0531	amino acid
CVS42_RS21385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS42_RS21390	COG0531	amino acid
CVS42_RS21395	COG2731	YhcH YjgK YiaL family protein
CVS42_RS21400	COG3250	beta-galactosidase activity
CVS42_RS21405	COG1609	Transcriptional regulator
CVS42_RS21445	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CVS42_RS21450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVS42_RS21450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVS42_RS21460	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CVS42_RS21465	COG3074	FtsZ-dependent cytokinesis
CVS42_RS21475	COG1045	serine acetyltransferase
CVS42_RS21485	COG0745	RESPONSE REGULATOR receiver
CVS42_RS21490	COG2205	protein histidine kinase activity
CVS42_RS21495	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CVS42_RS21500	COG0534	Mate efflux family protein
CVS42_RS21515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CVS42_RS21520	COG2937	Belongs to the GPAT DAPAT family
CVS42_RS21525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CVS42_RS21530	COG3161	chorismate lyase activity
CVS42_RS21555	COG0604	alcohol dehydrogenase
CVS42_RS21560	COG1519	Transferase
CVS42_RS21565	COG0859	PFAM glycosyl transferase family 9
CVS42_RS21570	COG0463	Glycosyl transferase, family 2
CVS42_RS21575	COG0859	PFAM glycosyl transferase family 9
CVS42_RS21580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CVS42_RS21585	COG2990	Protein conserved in bacteria
CVS42_RS21590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CVS42_RS21600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CVS42_RS21605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CVS42_RS21610	COG2003	Belongs to the UPF0758 family
CVS42_RS21615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CVS42_RS21620	COG0756	dUTP diphosphatase activity
CVS42_RS21625	COG1309	transcriptional regulator
CVS42_RS21630	COG0668	transmembrane transport
CVS42_RS21635	COG0166	Belongs to the GPI family
CVS42_RS21640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CVS42_RS21660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS42_RS21660	COG1042	CoA-binding domain protein
CVS42_RS21660	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS42_RS21695	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CVS42_RS21700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CVS42_RS21705	COG1739	Uncharacterized protein family UPF0029
CVS42_RS21710	COG0006	proline dipeptidase activity
CVS42_RS21715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS42_RS21720	COG1024	Enoyl-CoA hydratase
CVS42_RS21720	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS42_RS21725	COG0183	Belongs to the thiolase family
CVS42_RS21750	COG0425	Belongs to the sulfur carrier protein TusA family
CVS42_RS21755	COG0251	oxidation-reduction process
CVS42_RS21760	COG2885	chlorophyll binding
CVS42_RS21765	COG2818	Glycosylase
CVS42_RS21770	COG0752	glycyl-tRNA synthetase alpha subunit
CVS42_RS21775	COG0751	glycine-tRNA ligase activity
CVS42_RS21785	COG2199	diguanylate cyclase activity
CVS42_RS21785	COG2200	EAL domain
CVS42_RS21785	COG2202	Pas domain
CVS42_RS21830	COG1609	Transcriptional regulator
CVS42_RS21860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVS42_RS21875	COG2960	long-chain fatty acid transporting porin activity
CVS42_RS21880	COG5001	Diguanylate cyclase
CVS42_RS21890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CVS42_RS21905	COG3118	belongs to the thioredoxin family
CVS42_RS21910	COG0513	Belongs to the DEAD box helicase family
CVS42_RS21915	COG0248	Ppx GppA phosphatase
CVS42_RS21925	COG0742	ribosomal rna small subunit methyltransferase
CVS42_RS21945	COG3469	chitinase activity
CVS42_RS21950	COG3397	chitin binding
CVS42_RS21960	COG0084	hydrolase, TatD family'
CVS42_RS21965	COG0805	protein transport
CVS42_RS21970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS42_RS21975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS42_RS21980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CVS42_RS21985	COG3165	ubiquinone biosynthetic process from chorismate
CVS42_RS21990	COG2226	methyltransferase
CVS42_RS21995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CVS42_RS22000	COG0402	S-adenosylhomocysteine deaminase activity
CVS42_RS22005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CVS42_RS22040	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CVS42_RS22045	COG0848	biopolymer transport protein
CVS42_RS22050	COG0811	peptide transport
CVS42_RS22055	COG0811	peptide transport
CVS42_RS22065	COG2771	luxR family
CVS42_RS22070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVS42_RS22075	COG1349	DNA-binding transcription factor activity
CVS42_RS22080	COG0745	RESPONSE REGULATOR receiver
CVS42_RS22085	COG2205	protein histidine kinase activity
CVS42_RS22100	COG4452	Inner membrane protein CreD
CVS42_RS22105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CVS42_RS22110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CVS42_RS22115	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CVS42_RS22120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CVS42_RS22125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CVS42_RS22130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CVS42_RS22135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CVS42_RS22145	COG0356	it plays a direct role in the translocation of protons across the membrane
CVS42_RS22155	COG1475	DNA binding
CVS42_RS22160	COG1192	Involved in chromosome partitioning
CVS42_RS22165	COG0357	Ribosomal RNA small subunit methyltransferase G
CVS42_RS22170	COG0445	tRNA wobble uridine modification
CVS42_RS22175	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CVS42_RS22185	COG4615	Cyclic peptide transporter
CVS42_RS22190	COG1120	ATPase activity
CVS42_RS22195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component