locus-tag	class	description
ACAM_0003	COG2217	Heavy metal translocating P-type atpase
ACAM_0005	COG0531	amino acid
ACAM_0007	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACAM_0008	COG0129	dihydroxy-acid dehydratase activity
ACAM_0010	COG1070	Carbohydrate kinase
ACAM_0017	COG3118	belongs to the thioredoxin family
ACAM_0020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACAM_0021	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACAM_0024	COG1653	transport
ACAM_0025	COG1175	transmembrane transport
ACAM_0026	COG0395	ABC-type sugar transport system, permease component
ACAM_0027	COG3842	ATPase activity
ACAM_0028	COG0134	indole-3-glycerol-phosphate synthase activity
ACAM_0029	COG0135	phosphoribosylanthranilate isomerase activity
ACAM_0030	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ACAM_0031	COG0159	tryptophan synthase activity
ACAM_0032	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACAM_0033	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACAM_0034	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACAM_0034	COG0512	Glutamine amidotransferase of anthranilate synthase
ACAM_0037	COG0581	inorganic phosphate transmembrane transporter activity
ACAM_0038	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACAM_0039	COG0704	Plays a role in the regulation of phosphate uptake
ACAM_0041	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACAM_0044	COG1024	Enoyl-CoA hydratase
ACAM_0046	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACAM_0048	COG1129	ABC transporter
ACAM_0050	COG1079	Belongs to the binding-protein-dependent transport system permease family
ACAM_0054	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACAM_0058	COG0315	cyclic pyranopterin monophosphate synthase activity
ACAM_0058	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACAM_0060	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ACAM_0063	COG0778	Nitroreductase
ACAM_0066	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACAM_0070	COG0312	modulator of DNA gyrase
ACAM_0071	COG0312	modulator of DNA gyrase
ACAM_0076	COG0417	DNA replication proofreading
ACAM_0077	COG0247	lactate metabolic process
ACAM_0077	COG2181	nitrate reductase activity
ACAM_0081	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ACAM_0085	COG0419	ATPase involved in DNA repair
ACAM_0085	COG0419	ATPase involved in DNA repair
ACAM_0092	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACAM_0099	COG0714	Associated with various cellular activities
ACAM_0105	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACAM_0107	COG0405	Gamma-glutamyltransferase
ACAM_0109	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACAM_0113	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACAM_0126	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACAM_0129	COG1012	belongs to the aldehyde dehydrogenase family
ACAM_0133	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACAM_0134	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACAM_0135	COG0126	phosphoglycerate kinase activity
ACAM_0138	COG1763	Mo-molybdopterin cofactor biosynthetic process
ACAM_0139	COG0746	molybdenum cofactor guanylyltransferase activity
ACAM_0141	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACAM_0142	COG1872	DUF167
ACAM_0143	COG0730	response to heat
ACAM_0147	COG4581	dead DEAH box helicase
ACAM_0148	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACAM_0154	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACAM_0156	COG1201	RNA secondary structure unwinding
ACAM_0160	COG0517	IMP dehydrogenase activity
ACAM_0160	COG1994	Peptidase M50
ACAM_0165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACAM_0166	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACAM_0170	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACAM_0172	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACAM_0174	COG0089	rRNA binding
ACAM_0175	COG0489	protein tyrosine kinase activity
ACAM_0176	COG4109	DRTGG domain
ACAM_0178	COG0516	GMP reductase activity
ACAM_0178	COG0517	IMP dehydrogenase activity
ACAM_0187	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ACAM_0188	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ACAM_0189	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACAM_0190	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACAM_0191	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACAM_0193	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACAM_0198	COG1139	Iron-sulfur cluster binding protein
ACAM_0199	COG0167	dihydroorotate dehydrogenase activity
ACAM_0201	COG0584	glycerophosphoryl diester phosphodiesterase
ACAM_0220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACAM_0229	COG0277	FAD linked oxidase domain protein
ACAM_0233	COG0427	acetyl-CoA hydrolase
ACAM_0237	COG0010	Belongs to the arginase family
ACAM_0238	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACAM_0239	COG0693	protein deglycase activity
ACAM_0244	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAM_0246	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACAM_0247	COG0717	Belongs to the dCTP deaminase family
ACAM_0249	COG2366	antibiotic biosynthetic process
ACAM_0251	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACAM_0254	COG1607	acyl-coa hydrolase
ACAM_0261	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACAM_0262	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACAM_0264	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACAM_0265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACAM_0266	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACAM_0267	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACAM_0270	COG0255	Belongs to the universal ribosomal protein uL29 family
ACAM_0272	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACAM_0273	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACAM_0277	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACAM_0281	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACAM_0282	COG0517	IMP dehydrogenase activity
ACAM_0282	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACAM_0284	COG1960	acyl-CoA dehydrogenase activity
ACAM_0287	COG0281	malic enzyme
ACAM_0288	COG0318	PFAM AMP-dependent synthetase and ligase
ACAM_0293	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
ACAM_0294	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
ACAM_0305	COG0084	hydrolase, TatD family'
ACAM_0308	COG0463	Glycosyl transferase, family 2
ACAM_0309	COG1573	uracil-dna glycosylase
ACAM_0312	COG2255	four-way junction helicase activity
ACAM_0314	COG1185	polyribonucleotide nucleotidyltransferase activity
ACAM_0325	COG1098	S1 RNA binding domain
ACAM_0328	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACAM_0332	COG1489	DNA binding
ACAM_0333	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACAM_0346	COG1468	defense response to virus
ACAM_0346	COG1518	maintenance of DNA repeat elements
ACAM_0378	COG0277	FAD linked oxidase domain protein
ACAM_0385	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACAM_0394	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACAM_0395	COG0430	RNA-3'-phosphate cyclase activity
ACAM_0397	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ACAM_0397	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACAM_0399	COG1047	Peptidyl-prolyl cis-trans
ACAM_0400	COG0371	Dehydrogenase
ACAM_0401	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACAM_0402	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACAM_0406	COG0006	proline dipeptidase activity
ACAM_0413	COG0037	tRNA processing
ACAM_0418	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACAM_0424	COG2890	protein-(glutamine-N5) methyltransferase activity
ACAM_0425	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ACAM_0426	COG0116	Belongs to the methyltransferase superfamily
ACAM_0432	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACAM_0434	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACAM_0436	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACAM_0437	COG1605	Chorismate mutase
ACAM_0437	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACAM_0438	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACAM_0439	COG3959	Transketolase, thiamine diphosphate binding domain
ACAM_0442	COG1024	Enoyl-CoA hydratase
ACAM_0446	COG1252	NADH dehydrogenase
ACAM_0473	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ACAM_0475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACAM_0478	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACAM_0480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ACAM_0482	COG3118	belongs to the thioredoxin family
ACAM_0485	COG0574	Belongs to the PEP-utilizing enzyme family
ACAM_0485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACAM_0491	COG0124	histidyl-tRNA synthetase
ACAM_0493	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACAM_0495	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ACAM_0497	COG0039	L-malate dehydrogenase activity
ACAM_0499	COG0436	Aminotransferase
ACAM_0500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAM_0500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAM_0501	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACAM_0502	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACAM_0510	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ACAM_0511	COG0538	isocitrate dehydrogenase activity
ACAM_0513	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ACAM_0515	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ACAM_0524	COG4948	Mandelate Racemase Muconate Lactonizing
ACAM_0525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACAM_0526	COG1960	acyl-CoA dehydrogenase activity
ACAM_0534	COG2084	Dehydrogenase
ACAM_0538	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACAM_0549	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
ACAM_0551	COG2239	Acts as a magnesium transporter
ACAM_0559	COG1845	cytochrome c oxidase, subunit III
ACAM_0559	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACAM_0565	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACAM_0567	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ACAM_0568	COG1012	belongs to the aldehyde dehydrogenase family
ACAM_0569	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACAM_0584	COG1136	(ABC) transporter
ACAM_0593	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACAM_0595	COG0459	protein refolding
ACAM_0596	COG1028	Short-chain dehydrogenase reductase Sdr
ACAM_0603	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACAM_0606	COG0183	Belongs to the thiolase family
ACAM_0611	COG0493	'glutamate synthase
ACAM_0615	COG1177	transmembrane transport
ACAM_0616	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACAM_0617	COG3842	ATPase activity
ACAM_0618	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACAM_0619	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACAM_0621	COG2009	succinate dehydrogenase
ACAM_0623	COG0509	glycine decarboxylation via glycine cleavage system
ACAM_0626	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACAM_0629	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACAM_0630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAM_0637	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACAM_0644	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACAM_0646	COG0154	amidase activity
ACAM_0651	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACAM_0653	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACAM_0654	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACAM_0655	COG0813	purine-nucleoside phosphorylase activity
ACAM_0657	COG2379	hydroxypyruvate reductase
ACAM_0667	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACAM_0670	COG0495	leucyl-tRNA aminoacylation
ACAM_0672	COG4133	protoheme IX ABC transporter activity
ACAM_0680	COG1252	NADH dehydrogenase
ACAM_0681	COG0778	Nitroreductase
ACAM_0682	COG0501	Belongs to the peptidase M48B family
ACAM_0684	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACAM_0685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACAM_0686	COG1121	(ABC) transporter
ACAM_0687	COG2078	PFAM AMMECR1 domain protein
ACAM_0687	COG3885	ferrous iron binding
ACAM_0689	COG0492	ferredoxin-NADP+ reductase activity
ACAM_0690	COG0492	ferredoxin-NADP+ reductase activity
ACAM_0694	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACAM_0695	COG1061	Type III restriction enzyme res subunit
ACAM_0708	COG1793	dna ligase
ACAM_0709	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACAM_0709	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACAM_0711	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACAM_0712	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACAM_0713	COG1980	fructose-bisphosphate aldolase activity
ACAM_0716	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACAM_0717	COG1129	ABC transporter
ACAM_0720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACAM_0723	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACAM_0725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACAM_0726	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACAM_0728	COG0527	aspartate kinase activity
ACAM_0730	COG0460	homoserine dehydrogenase
ACAM_0735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACAM_0737	COG0012	GTP binding
ACAM_0750	COG0529	Catalyzes the synthesis of activated sulfate
ACAM_0753	COG2046	Belongs to the sulfate adenylyltransferase family
ACAM_0761	COG0463	Glycosyl transferase, family 2
ACAM_0762	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ACAM_0763	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACAM_0766	COG1960	acyl-CoA dehydrogenase activity
ACAM_0769	COG1404	Belongs to the peptidase S8 family
ACAM_0776	COG0626	cystathionine gamma-synthase activity
ACAM_0796	COG1136	(ABC) transporter
ACAM_0797	COG1131	(ABC) transporter
ACAM_0802	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACAM_0806	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACAM_0816	COG0123	including yeast histone deacetylase and acetoin utilization protein
ACAM_0818	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ACAM_0819	COG1140	nitrate reductase beta subunit
ACAM_0822	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ACAM_0827	COG0318	PFAM AMP-dependent synthetase and ligase
ACAM_0829	COG0318	PFAM AMP-dependent synthetase and ligase
ACAM_0832	COG0714	Associated with various cellular activities
ACAM_0844	COG1363	Peptidase, m42
ACAM_0848	COG1110	DNA topoisomerase II activity
ACAM_0851	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACAM_0853	COG0315	cyclic pyranopterin monophosphate synthase activity
ACAM_0856	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACAM_0864	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACAM_0865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAM_0869	COG1110	DNA topoisomerase II activity
ACAM_0874	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACAM_0875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACAM_0878	COG0747	negative chemotaxis
ACAM_0879	COG0601	transmembrane transport
ACAM_0880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAM_0881	COG0444	Belongs to the ABC transporter superfamily
ACAM_0882	COG4608	Belongs to the ABC transporter superfamily
ACAM_0883	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACAM_0888	COG1007	ATP synthesis coupled electron transport
ACAM_0889	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACAM_0890	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAM_0894	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACAM_0895	COG0649	NAD binding
ACAM_0896	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAM_0897	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACAM_0899	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACAM_0900	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ACAM_0909	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACAM_0910	COG1185	polyribonucleotide nucleotidyltransferase activity
ACAM_0912	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ACAM_0916	COG2217	Heavy metal translocating P-type atpase
ACAM_0920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACAM_0921	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACAM_0923	COG0189	ligase activity
ACAM_0924	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACAM_0925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACAM_0926	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACAM_0927	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACAM_0928	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACAM_0929	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACAM_0929	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACAM_0932	COG0494	nUDIX hydrolase
ACAM_0936	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACAM_0937	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACAM_0937	COG1648	precorrin-2 dehydrogenase activity
ACAM_0941	COG0864	Transcriptional regulator
ACAM_0943	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACAM_0944	COG0251	oxidation-reduction process
ACAM_0945	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACAM_0946	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ACAM_0947	COG0516	GMP reductase activity
ACAM_0947	COG0517	IMP dehydrogenase activity
ACAM_0952	COG1213	nucleotidyl transferase
ACAM_0952	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACAM_0955	COG0432	Pfam Uncharacterised protein family UPF0047
ACAM_0956	COG2255	four-way junction helicase activity
ACAM_0957	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACAM_0962	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACAM_0966	COG2022	thiamine diphosphate biosynthetic process
ACAM_0968	COG1444	tRNA N-acetyltransferase activity
ACAM_0971	COG0823	Involved in the tonB-independent uptake of proteins
ACAM_0971	COG1506	peptidase
ACAM_0972	COG1131	(ABC) transporter
ACAM_0980	COG1458	PINc domain ribonuclease
ACAM_0984	COG2217	Heavy metal translocating P-type atpase
ACAM_0985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACAM_0986	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACAM_0991	COG4608	Belongs to the ABC transporter superfamily
ACAM_0992	COG0444	Belongs to the ABC transporter superfamily
ACAM_0993	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAM_0994	COG0601	transmembrane transport
ACAM_0998	COG1254	Belongs to the acylphosphatase family
ACAM_0999	COG0215	cysteine-tRNA ligase activity
ACAM_1000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACAM_1002	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
ACAM_1006	COG0504	CTP synthase activity
ACAM_1014	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
ACAM_1017	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACAM_1019	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACAM_1027	COG3842	ATPase activity
ACAM_1028	COG0010	Belongs to the arginase family
ACAM_1029	COG0423	glycine-tRNA ligase activity
ACAM_1033	COG0163	prenyltransferase activity
ACAM_1034	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ACAM_1036	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACAM_1037	COG0535	radical SAM domain protein
ACAM_1042	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ACAM_1043	COG0540	Belongs to the ATCase OTCase family
ACAM_1045	COG1324	tolerance protein
ACAM_1046	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACAM_1048	COG0022	dehydrogenase e1 component
ACAM_1050	COG1960	acyl-CoA dehydrogenase activity
ACAM_1053	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACAM_1053	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACAM_1061	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACAM_1066	COG0396	ATPase activity
ACAM_1071	COG0372	Belongs to the citrate synthase family
ACAM_1074	COG0154	amidase activity
ACAM_1075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACAM_1078	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACAM_1080	COG3118	belongs to the thioredoxin family
ACAM_1084	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACAM_1087	COG1177	transmembrane transport
ACAM_1088	COG3842	ATPase activity
ACAM_1091	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACAM_1092	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACAM_1093	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACAM_1096	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACAM_1097	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACAM_1108	COG1304	FMN binding
ACAM_1109	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACAM_1111	COG1355	regulation of microtubule-based process
ACAM_1112	COG0534	Mate efflux family protein
ACAM_1113	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ACAM_1116	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACAM_1119	COG1012	belongs to the aldehyde dehydrogenase family
ACAM_1123	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ACAM_1127	COG0483	inositol monophosphate 1-phosphatase activity
ACAM_1131	COG0525	valine-tRNA ligase activity
ACAM_1137	COG0114	fumarate hydratase activity
ACAM_1144	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACAM_1147	COG4555	ABC transporter
ACAM_1148	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACAM_1149	COG0823	Involved in the tonB-independent uptake of proteins
ACAM_1149	COG1506	peptidase
ACAM_1149	COG4946	Tricorn protease homolog
ACAM_1151	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACAM_1153	COG1234	tRNA 3'-trailer cleavage
ACAM_1154	COG0517	IMP dehydrogenase activity
ACAM_1154	COG0516	GMP reductase activity
ACAM_1156	COG0051	transcription antitermination factor activity, RNA binding
ACAM_1157	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACAM_1158	COG0049	tRNA binding
ACAM_1162	COG1358	cellular component organization or biogenesis
ACAM_1163	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACAM_1164	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACAM_1165	COG0085	RNA polymerase activity
ACAM_1177	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACAM_1178	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACAM_1181	COG0109	protoheme IX farnesyltransferase activity
ACAM_1184	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACAM_1190	COG0765	amino acid transport
ACAM_1191	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ACAM_1202	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACAM_1204	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACAM_1208	COG1668	transmembrane transport
ACAM_1213	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACAM_1226	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACAM_1228	COG0656	L-ascorbic acid biosynthetic process
ACAM_1236	COG0549	Belongs to the carbamate kinase family
ACAM_1240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACAM_1242	COG2151	metal-sulfur cluster biosynthetic enzyme
ACAM_1244	COG1546	Belongs to the CinA family
ACAM_1244	COG1058	Belongs to the CinA family
ACAM_1251	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACAM_1261	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACAM_1263	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAM_1269	COG0735	belongs to the Fur family
ACAM_1273	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACAM_1274	COG0309	Hydrogenase expression formation protein (HypE)
ACAM_1275	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACAM_1276	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACAM_1284	COG3842	ATPase activity
ACAM_1285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACAM_1287	COG0438	transferase activity, transferring glycosyl groups
ACAM_1289	COG0626	cystathionine gamma-synthase activity
ACAM_1294	COG0459	protein refolding
ACAM_1295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACAM_1300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACAM_1302	COG2309	aminopeptidase activity
ACAM_1304	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACAM_1305	COG0037	tRNA processing
ACAM_1309	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACAM_1316	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACAM_1317	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ACAM_1318	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACAM_1319	COG0183	Belongs to the thiolase family
ACAM_1320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACAM_1327	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACAM_1328	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACAM_1329	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACAM_1331	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACAM_1331	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACAM_1332	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACAM_1334	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACAM_1336	COG2358	TRAP transporter, solute receptor (TAXI family
ACAM_1339	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACAM_1340	COG0174	glutamine synthetase
ACAM_1341	COG1201	RNA secondary structure unwinding
ACAM_1344	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
ACAM_1346	COG0330	HflC and HflK could
ACAM_1347	COG0805	protein transport
ACAM_1348	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACAM_1350	COG1122	ATPase activity
ACAM_1354	COG1960	acyl-CoA dehydrogenase activity
ACAM_1357	COG1966	Carbon starvation protein
ACAM_1359	COG0003	Pfam Anion-transporting ATPase
ACAM_1360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACAM_1363	COG0081	regulation of translation
ACAM_1364	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACAM_1375	COG1201	RNA secondary structure unwinding
ACAM_1377	COG0017	Asparaginyl-tRNA synthetase
ACAM_1382	COG0252	asparaginase activity
ACAM_1383	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACAM_1391	COG2255	four-way junction helicase activity
ACAM_1393	COG0746	molybdenum cofactor guanylyltransferase activity
ACAM_1395	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACAM_1395	COG3608	succinylglutamate desuccinylase aspartoacylase
ACAM_1405	COG2094	Belongs to the DNA glycosylase MPG family
ACAM_1406	COG0436	Aminotransferase
ACAM_1409	COG3833	ABC-type maltose transport systems, permease component
ACAM_1412	COG0747	negative chemotaxis
ACAM_1413	COG0601	transmembrane transport
ACAM_1414	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACAM_1416	COG4608	Belongs to the ABC transporter superfamily
ACAM_1421	COG1122	ATPase activity
ACAM_1422	COG3118	belongs to the thioredoxin family
ACAM_1425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACAM_1426	COG0450	alkyl hydroperoxide reductase
ACAM_1427	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACAM_1428	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACAM_1428	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACAM_1430	COG0318	PFAM AMP-dependent synthetase and ligase
ACAM_1434	COG4946	Tricorn protease homolog
ACAM_1434	COG1506	peptidase
ACAM_1434	COG0823	Involved in the tonB-independent uptake of proteins
ACAM_1435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACAM_1439	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACAM_1440	COG0181	hydroxymethylbilane synthase activity
ACAM_1441	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACAM_1442	COG0113	porphobilinogen synthase activity
ACAM_1444	COG0072	phenylalanine-tRNA ligase activity
ACAM_1445	COG1469	GTP cyclohydrolase I activity
ACAM_1452	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ACAM_1453	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ACAM_1454	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACAM_1460	COG0442	prolyl-tRNA aminoacylation
ACAM_1473	COG0095	Lipoate-protein ligase
ACAM_1474	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACAM_1476	COG0284	orotidine-5'-phosphate decarboxylase activity
ACAM_1477	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACAM_1478	COG1335	isochorismatase
ACAM_1486	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACAM_1486	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACAM_1490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACAM_1491	COG0105	UTP biosynthetic process
ACAM_1495	COG2031	fatty acid transporter
ACAM_1500	COG1444	tRNA N-acetyltransferase activity
ACAM_1501	COG0009	L-threonylcarbamoyladenylate synthase
ACAM_1502	COG0351	phosphomethylpyrimidine kinase
ACAM_1504	COG1122	ATPase activity
ACAM_1505	COG1129	ABC transporter
ACAM_1514	COG0534	Mate efflux family protein
ACAM_1516	COG2086	electron transfer activity
ACAM_1517	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACAM_1518	COG0644	oxidoreductase
ACAM_1519	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACAM_1525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACAM_1529	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACAM_1531	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACAM_1532	COG4946	Tricorn protease homolog
ACAM_1532	COG1506	peptidase
ACAM_1532	COG0823	Involved in the tonB-independent uptake of proteins
ACAM_1535	COG2848	UPF0210 protein
ACAM_1537	COG0434	BtpA family
ACAM_1538	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACAM_1539	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACAM_1539	COG0519	Catalyzes the synthesis of GMP from XMP
ACAM_1543	COG0148	phosphopyruvate hydratase activity
ACAM_1544	COG0357	Ribosomal RNA small subunit methyltransferase G
ACAM_1549	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACAM_1550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACAM_1550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACAM_1558	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACAM_1566	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACAM_1566	COG0517	IMP dehydrogenase activity
ACAM_1570	COG0537	adenosine 5'-monophosphoramidase activity
ACAM_1572	COG2095	MarC family integral membrane protein
ACAM_1578	COG1028	Short-chain dehydrogenase reductase Sdr
ACAM_1580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACAM_1585	COG1733	regulation of RNA biosynthetic process
ACAM_1587	COG0667	Aldo Keto reductase
ACAM_1588	COG1331	Highly conserved protein containing a thioredoxin domain
ACAM_1592	COG0442	prolyl-tRNA aminoacylation
ACAM_1597	COG0243	molybdopterin cofactor binding
ACAM_1602	COG0864	Transcriptional regulator
ACAM_1603	COG2217	Heavy metal translocating P-type atpase
ACAM_1616	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACAM_1621	COG2133	pyrroloquinoline quinone binding
ACAM_1622	COG1079	Belongs to the binding-protein-dependent transport system permease family
ACAM_1623	COG4603	Belongs to the binding-protein-dependent transport system permease family
ACAM_1624	COG1129	ABC transporter
ACAM_1627	COG2897	thiosulfate sulfurtransferase activity
ACAM_1628	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACAM_1631	COG1834	amidinotransferase
ACAM_1633	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA