locus-tag	class	description
B9057_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B9057_RS00025	COG1280	lysine exporter protein (LysE YggA)
B9057_RS00035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B9057_RS00040	COG1346	cytolysis
B9057_RS00055	COG1054	Belongs to the UPF0176 family
B9057_RS00060	COG1335	isochorismatase
B9057_RS00065	COG0659	secondary active sulfate transmembrane transporter activity
B9057_RS00085	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B9057_RS00095	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
B9057_RS00100	COG2270	Major facilitator Superfamily
B9057_RS00115	COG3047	cAMP biosynthetic process
B9057_RS00115	COG2885	chlorophyll binding
B9057_RS00120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B9057_RS00125	COG0154	amidase activity
B9057_RS00130	COG0436	Aminotransferase
B9057_RS00135	COG1674	ftsk spoiiie
B9057_RS00160	COG0564	pseudouridine synthase activity
B9057_RS00170	COG0450	alkyl hydroperoxide reductase
B9057_RS00175	COG0189	ligase activity
B9057_RS00175	COG4067	protein conserved in archaea
B9057_RS00180	COG0189	ligase activity
B9057_RS00195	COG1185	polyribonucleotide nucleotidyltransferase activity
B9057_RS00200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B9057_RS00220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B9057_RS00230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B9057_RS00235	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B9057_RS00245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B9057_RS00245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B9057_RS00255	COG0138	bifunctional purine biosynthesis protein purh
B9057_RS00260	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B9057_RS00270	COG0612	Peptidase, M16
B9057_RS00275	COG0612	Peptidase, M16
B9057_RS00280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B9057_RS00290	COG3806	Anti-sigma factor
B9057_RS00295	COG1595	DNA-templated transcription, initiation
B9057_RS00315	COG0300	oxidoreductase activity
B9057_RS00330	COG0347	Belongs to the P(II) protein family
B9057_RS00335	COG0004	ammonium transporteR
B9057_RS00345	COG2897	thiosulfate sulfurtransferase activity
B9057_RS00350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B9057_RS00360	COG0697	spore germination
B9057_RS00365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B9057_RS00390	COG1304	FMN binding
B9057_RS00445	COG0860	N-Acetylmuramoyl-L-alanine amidase
B9057_RS00445	COG3409	Peptidoglycan-binding domain 1 protein
B9057_RS00450	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B9057_RS00465	COG0435	Glutathione S-transferase
B9057_RS00510	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B9057_RS00515	COG0242	peptide deformylase activity
B9057_RS00520	COG0242	peptide deformylase activity
B9057_RS00525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B9057_RS00530	COG2860	membrane
B9057_RS00545	COG0012	GTP binding
B9057_RS00555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B9057_RS00560	COG1183	phosphatidylcholine synthase activity
B9057_RS00565	COG0688	phosphatidylethanolamine metabolic process
B9057_RS00575	COG0193	aminoacyl-tRNA hydrolase activity
B9057_RS00605	COG0133	tryptophan synthase activity
B9057_RS00610	COG0135	phosphoribosylanthranilate isomerase activity
B9057_RS00620	COG0776	regulation of translation
B9057_RS00625	COG0539	negative regulation of cytoplasmic translation
B9057_RS00630	COG0778	Nitroreductase
B9057_RS00635	COG1733	regulation of RNA biosynthetic process
B9057_RS00645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B9057_RS00650	COG0813	purine-nucleoside phosphorylase activity
B9057_RS00660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9057_RS00660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9057_RS00670	COG0604	alcohol dehydrogenase
B9057_RS00690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B9057_RS00700	COG0730	response to heat
B9057_RS00705	COG0328	RNA-DNA hybrid ribonuclease activity
B9057_RS00715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B9057_RS00725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B9057_RS00730	COG1758	RNA polymerase activity
B9057_RS00735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B9057_RS00745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B9057_RS00750	COG0736	holo-[acyl-carrier-protein] synthase activity
B9057_RS00755	COG0681	Belongs to the peptidase S26 family
B9057_RS00760	COG0681	Belongs to the peptidase S26 family
B9057_RS00765	COG0571	ribonuclease III activity
B9057_RS00770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B9057_RS00785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B9057_RS00795	COG1660	Displays ATPase and GTPase activities
B9057_RS00805	COG2205	protein histidine kinase activity
B9057_RS00810	COG0745	RESPONSE REGULATOR receiver
B9057_RS00815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B9057_RS00835	COG1381	Involved in DNA repair and RecF pathway recombination
B9057_RS00840	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9057_RS00870	COG0300	oxidoreductase activity
B9057_RS00880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B9057_RS00890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B9057_RS00915	COG0250	Participates in transcription elongation, termination and antitermination
B9057_RS00920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B9057_RS00925	COG0081	regulation of translation
B9057_RS00930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B9057_RS00935	COG0222	ribosome binding
B9057_RS00940	COG0085	RNA polymerase activity
B9057_RS00945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B9057_RS00950	COG0697	spore germination
B9057_RS00960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B9057_RS00965	COG0049	tRNA binding
B9057_RS00970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B9057_RS00975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B9057_RS00980	COG0051	transcription antitermination factor activity, RNA binding
B9057_RS00985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B9057_RS00990	COG0088	Forms part of the polypeptide exit tunnel
B9057_RS00995	COG0089	rRNA binding
B9057_RS01000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B9057_RS01005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B9057_RS01010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B9057_RS01015	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B9057_RS01020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B9057_RS01030	COG0255	Belongs to the universal ribosomal protein uL29 family
B9057_RS01035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B9057_RS01045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B9057_RS01050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B9057_RS01055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B9057_RS01060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B9057_RS01065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B9057_RS01070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B9057_RS01075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B9057_RS01080	COG1841	ribosomal large subunit assembly
B9057_RS01090	COG0200	Binds to the 23S rRNA
B9057_RS01100	COG0563	adenylate kinase activity
B9057_RS01105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B9057_RS01110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B9057_RS01115	COG0202	RNA polymerase activity
B9057_RS01135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B9057_RS01150	COG0546	phosphoglycolate phosphatase activity
B9057_RS01160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B9057_RS01165	COG4597	amino acid ABC transporter
B9057_RS01170	COG0765	amino acid transport
B9057_RS01175	COG1126	abc transporter atp-binding protein
B9057_RS01185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B9057_RS01190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B9057_RS01195	COG0706	membrane insertase activity
B9057_RS01200	COG5001	Diguanylate cyclase
B9057_RS01200	COG3300	MHYT domain
B9057_RS01205	COG0037	tRNA processing
B9057_RS01210	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B9057_RS01215	COG0594	ribonuclease P activity
B9057_RS01220	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B9057_RS01230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B9057_RS01235	COG5002	protein histidine kinase activity
B9057_RS01310	COG0640	Transcriptional regulator
B9057_RS01320	COG0556	nucleotide-excision repair
B9057_RS01340	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B9057_RS01355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B9057_RS01360	COG0667	Aldo Keto reductase
B9057_RS01365	COG0488	(ABC) transporter
B9057_RS01385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B9057_RS01400	COG1047	Peptidyl-prolyl cis-trans
B9057_RS01410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B9057_RS01415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B9057_RS01420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B9057_RS01435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B9057_RS01450	COG1702	phosphate starvation-inducible protein PhoH
B9057_RS01455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B9057_RS01460	COG1253	flavin adenine dinucleotide binding
B9057_RS01465	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B9057_RS01470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B9057_RS01475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B9057_RS01485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B9057_RS01490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B9057_RS01495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B9057_RS01500	COG1435	thymidine kinase activity
B9057_RS01515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B9057_RS01520	COG0512	Glutamine amidotransferase of anthranilate synthase
B9057_RS01520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B9057_RS01525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B9057_RS01530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B9057_RS01540	COG0346	lactoylglutathione lyase activity
B9057_RS01560	COG1872	DUF167
B9057_RS01580	COG2326	polyphosphate kinase activity
B9057_RS01615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B9057_RS01640	COG0842	Transport permease protein
B9057_RS01645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B9057_RS01655	COG0306	phosphate transporter
B9057_RS01665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B9057_RS01670	COG1643	Atp-dependent helicase
B9057_RS01675	COG0277	FAD linked oxidase domain protein
B9057_RS01680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B9057_RS01685	COG0612	Peptidase, M16
B9057_RS01705	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B9057_RS01715	COG0109	protoheme IX farnesyltransferase activity
B9057_RS01725	COG0312	modulator of DNA gyrase
B9057_RS01730	COG0758	DNA mediated transformation
B9057_RS01730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B9057_RS01740	COG1754	DNA topoisomerase type I activity
B9057_RS01740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B9057_RS01805	COG4964	Belongs to the GSP D family
B9057_RS01860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B9057_RS01865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B9057_RS01870	COG0659	secondary active sulfate transmembrane transporter activity
B9057_RS01895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B9057_RS01900	COG0527	aspartate kinase activity
B9057_RS01910	COG0840	transmembrane signaling receptor activity
B9057_RS01920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B9057_RS01930	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B9057_RS01935	COG5328	Belongs to the UPF0262 family
B9057_RS01955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9057_RS01960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B9057_RS01965	COG0424	maF-like protein
B9057_RS01975	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B9057_RS01990	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B9057_RS01995	COG2943	transferase activity, transferring hexosyl groups
B9057_RS02015	COG4181	ATPase activity
B9057_RS02045	COG3551	Protein conserved in bacteria
B9057_RS02065	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B9057_RS02070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B9057_RS02095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B9057_RS02100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B9057_RS02145	COG0508	dehydrogenase complex catalyzes the overall conversion of
B9057_RS02150	COG0567	Dehydrogenase, E1 component
B9057_RS02160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B9057_RS02165	COG0045	succinate-CoA ligase (ADP-forming) activity
B9057_RS02170	COG0039	L-malate dehydrogenase activity
B9057_RS02195	COG2030	dehydratase
B9057_RS02245	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B9057_RS02250	COG1079	Belongs to the binding-protein-dependent transport system permease family
B9057_RS02255	COG4603	Belongs to the binding-protein-dependent transport system permease family
B9057_RS02260	COG3845	ABC transporter
B9057_RS02265	COG1744	ABC transporter substrate-binding protein PnrA-like
B9057_RS02275	COG1214	PFAM Peptidase M22, glycoprotease
B9057_RS02280	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B9057_RS02295	COG0180	Tryptophanyl-tRNA synthetase
B9057_RS02315	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B9057_RS02325	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B9057_RS02330	COG0792	nuclease activity
B9057_RS02345	COG0606	chelatase, subunit chli
B9057_RS02375	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B9057_RS02380	COG0756	dUTP diphosphatase activity
B9057_RS02385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B9057_RS02390	COG0339	signal peptide processing
B9057_RS02420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B9057_RS02425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B9057_RS02450	COG1079	Belongs to the binding-protein-dependent transport system permease family
B9057_RS02455	COG4603	Belongs to the binding-protein-dependent transport system permease family
B9057_RS02460	COG3845	ABC transporter
B9057_RS02490	COG2900	Belongs to the SlyX family
B9057_RS02495	COG0124	histidyl-tRNA synthetase
B9057_RS02505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B9057_RS02520	COG1162	GTPase activity
B9057_RS02525	COG1012	belongs to the aldehyde dehydrogenase family
B9057_RS02530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B9057_RS02535	COG2353	YceI-like domain
B9057_RS02575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B9057_RS02640	COG2197	response regulator
B9057_RS02665	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B9057_RS02680	COG0772	Belongs to the SEDS family
B9057_RS02685	COG0768	penicillin binding
B9057_RS02760	COG0395	ABC-type sugar transport system, permease component
B9057_RS02770	COG1653	transport
B9057_RS02790	COG1073	alpha beta
B9057_RS02810	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B9057_RS02815	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B9057_RS02820	COG3639	organic phosphonate transmembrane transporter activity
B9057_RS02825	COG3639	organic phosphonate transmembrane transporter activity
B9057_RS02835	COG2188	Transcriptional regulator
B9057_RS02840	COG3624	Phosphonate C-P lyase system protein PhnG
B9057_RS02850	COG3626	phosphonate metabolism
B9057_RS02855	COG3627	carbon phosphorus lyase activity
B9057_RS02860	COG4107	phosphonate C-P lyase system protein PhnK
B9057_RS02865	COG4778	phosphonate C-P lyase system protein PhnL
B9057_RS02875	COG3454	Phosphonate metabolism
B9057_RS02910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B9057_RS02915	COG2169	Transcriptional regulator
B9057_RS02915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B9057_RS02920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B9057_RS02925	COG0287	Prephenate dehydrogenase
B9057_RS02935	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B9057_RS02960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B9057_RS02970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B9057_RS02975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B9057_RS02980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B9057_RS02985	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B9057_RS02990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B9057_RS03010	COG2983	Belongs to the UPF0260 family
B9057_RS03015	COG0196	riboflavin kinase activity
B9057_RS03020	COG2030	dehydratase
B9057_RS03040	COG1227	inorganic diphosphatase activity
B9057_RS03055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B9057_RS03060	COG0459	protein refolding
B9057_RS03100	COG2390	Transcriptional regulator
B9057_RS03105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B9057_RS03115	COG2391	methyltransferase activity
B9057_RS03130	COG0785	Cytochrome C biogenesis protein
B9057_RS03155	COG3258	Cytochrome c
B9057_RS03165	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B9057_RS03180	COG0156	8-amino-7-oxononanoate synthase activity
B9057_RS03190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B9057_RS03195	COG0509	glycine decarboxylation via glycine cleavage system
B9057_RS03200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B9057_RS03200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B9057_RS03210	COG0019	diaminopimelate decarboxylase activity
B9057_RS03220	COG1940	carbohydrate kinase activity
B9057_RS03225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B9057_RS03235	COG1960	acyl-CoA dehydrogenase activity
B9057_RS03245	COG1024	Enoyl-CoA hydratase
B9057_RS03250	COG0657	acetylesterase activity
B9057_RS03260	COG3246	L-lysine catabolic process to acetate
B9057_RS03265	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9057_RS03265	COG0824	Thioesterase
B9057_RS03270	COG0747	negative chemotaxis
B9057_RS03275	COG0601	transmembrane transport
B9057_RS03280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9057_RS03305	COG4948	Mandelate Racemase Muconate Lactonizing
B9057_RS03325	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B9057_RS03325	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B9057_RS03350	COG1741	Belongs to the pirin family
B9057_RS03370	COG0358	DNA primase activity
B9057_RS03375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B9057_RS03385	COG0432	Pfam Uncharacterised protein family UPF0047
B9057_RS03395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B9057_RS03395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B9057_RS03420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B9057_RS03420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B9057_RS03425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B9057_RS03460	COG0564	pseudouridine synthase activity
B9057_RS03505	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B9057_RS03510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B9057_RS03515	COG1329	Transcriptional regulator
B9057_RS03520	COG1570	exodeoxyribonuclease VII activity
B9057_RS03550	COG0552	protein localization to endoplasmic reticulum
B9057_RS03560	COG2917	probably involved in intracellular septation
B9057_RS03570	COG0625	glutathione transferase activity
B9057_RS03580	COG1469	GTP cyclohydrolase I activity
B9057_RS03590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B9057_RS03600	COG0752	glycyl-tRNA synthetase alpha subunit
B9057_RS03610	COG0751	glycine-tRNA ligase activity
B9057_RS03615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B9057_RS03615	COG0574	Belongs to the PEP-utilizing enzyme family
B9057_RS03620	COG3409	Peptidoglycan-binding domain 1 protein
B9057_RS03620	COG3773	Cell wall hydrolase
B9057_RS03625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B9057_RS03630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B9057_RS03635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B9057_RS03640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B9057_RS03650	COG1522	sequence-specific DNA binding
B9057_RS03660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B9057_RS03670	COG1802	Transcriptional regulator
B9057_RS03675	COG1215	transferase activity, transferring glycosyl groups
B9057_RS03680	COG0505	Belongs to the CarA family
B9057_RS03685	COG1610	YqeY-like protein
B9057_RS03690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B9057_RS03705	COG0321	lipoyl(octanoyl) transferase activity
B9057_RS03730	COG3842	ATPase activity
B9057_RS03740	COG1176	ABC-type spermidine putrescine transport system, permease component I
B9057_RS03755	COG1234	tRNA 3'-trailer cleavage
B9057_RS03760	COG0084	hydrolase, TatD family'
B9057_RS03770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B9057_RS03895	COG1475	DNA binding
B9057_RS03940	COG0740	serine-type endopeptidase activity
B9057_RS04000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B9057_RS04015	COG1053	succinate dehydrogenase
B9057_RS04030	COG2855	membrane
B9057_RS04045	COG0583	DNA-binding transcription factor activity
B9057_RS04050	COG4584	PFAM Integrase catalytic
B9057_RS04065	COG0154	amidase activity
B9057_RS04105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9057_RS04115	COG4584	PFAM Integrase catalytic
B9057_RS04170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9057_RS04185	COG2197	response regulator
B9057_RS04190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B9057_RS04195	COG0318	PFAM AMP-dependent synthetase and ligase
B9057_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
B9057_RS04220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B9057_RS04230	COG2115	Belongs to the xylose isomerase family
B9057_RS04235	COG1070	Carbohydrate kinase
B9057_RS04245	COG4214	carbohydrate transport
B9057_RS04250	COG4213	ABC transporter substrate-binding protein
B9057_RS04265	COG1858	cytochrome C peroxidase
B9057_RS04275	COG0583	DNA-binding transcription factor activity
B9057_RS04280	COG2351	hydroxyisourate hydrolase activity
B9057_RS04290	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
B9057_RS04300	COG3257	ureidoglycine aminohydrolase activity
B9057_RS04305	COG0583	DNA-binding transcription factor activity
B9057_RS04310	COG4638	Rieske (2fe-2S)
B9057_RS04320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B9057_RS04330	COG0446	pyridine nucleotide-disulphide oxidoreductase
B9057_RS04330	COG1902	pentaerythritol trinitrate reductase activity
B9057_RS04335	COG1522	sequence-specific DNA binding
B9057_RS04345	COG0006	proline dipeptidase activity
B9057_RS04360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B9057_RS04365	COG4149	molybdate abc transporter
B9057_RS04370	COG0583	DNA-binding transcription factor activity
B9057_RS04375	COG1960	acyl-CoA dehydrogenase activity
B9057_RS04380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B9057_RS04395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B9057_RS04400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B9057_RS04410	COG0071	Belongs to the small heat shock protein (HSP20) family
B9057_RS04420	COG3038	cytochrome b561
B9057_RS04425	COG0492	ferredoxin-NADP+ reductase activity
B9057_RS04430	COG1522	sequence-specific DNA binding
B9057_RS04440	COG1496	oxidoreductase activity
B9057_RS04450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B9057_RS04465	COG0425	Belongs to the sulfur carrier protein TusA family
B9057_RS04470	COG0746	molybdenum cofactor guanylyltransferase activity
B9057_RS04475	COG1618	nucleotide phosphatase activity, acting on free nucleotides
B9057_RS04475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B9057_RS04480	COG1177	transmembrane transport
B9057_RS04485	COG1176	ABC-type spermidine putrescine transport system, permease component I
B9057_RS04490	COG3842	ATPase activity
B9057_RS04505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9057_RS04535	COG0101	tRNA pseudouridine synthase activity
B9057_RS04540	COG3106	COG3106 Predicted ATPase
B9057_RS04545	COG3768	UPF0283 membrane protein
B9057_RS04555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B9057_RS04565	COG4974	Belongs to the 'phage' integrase family
B9057_RS04570	COG1183	phosphatidylcholine synthase activity
B9057_RS04580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B9057_RS04590	COG2391	methyltransferase activity
B9057_RS04620	COG0632	four-way junction helicase activity
B9057_RS04625	COG2255	four-way junction helicase activity
B9057_RS04630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B9057_RS04640	COG0667	Aldo Keto reductase
B9057_RS04700	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B9057_RS04705	COG0735	belongs to the Fur family
B9057_RS04715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B9057_RS04720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B9057_RS04760	COG1187	pseudouridine synthase activity
B9057_RS04765	COG0590	tRNA wobble adenosine to inosine editing
B9057_RS04770	COG3023	N-Acetylmuramoyl-L-alanine amidase
B9057_RS04780	COG0154	amidase activity
B9057_RS04785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B9057_RS04790	COG0415	Belongs to the DNA photolyase family
B9057_RS04800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B9057_RS04810	COG0483	inositol monophosphate 1-phosphatase activity
B9057_RS04820	COG3321	synthase
B9057_RS04820	COG1028	Short-chain dehydrogenase reductase Sdr
B9057_RS04820	COG0604	alcohol dehydrogenase
B9057_RS04825	COG0583	DNA-binding transcription factor activity
B9057_RS04835	COG0670	Belongs to the BI1 family
B9057_RS04855	COG0402	S-adenosylhomocysteine deaminase activity
B9057_RS04860	COG2239	Acts as a magnesium transporter
B9057_RS04865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B9057_RS04870	COG1692	metallophosphoesterase
B9057_RS04875	COG0471	metal ion transport
B9057_RS04875	COG3273	potassium ion transport
B9057_RS04880	COG0217	transcriptional regulatory protein
B9057_RS04900	COG4175	Glycine betaine
B9057_RS04915	COG1309	transcriptional regulator
B9057_RS04920	COG3119	arylsulfatase activity
B9057_RS04945	COG3800	Transcriptional regulator
B9057_RS04945	COG1396	sequence-specific DNA binding
B9057_RS04955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B9057_RS04980	COG4770	biotin carboxylase activity
B9057_RS04995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9057_RS04995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B9057_RS05000	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B9057_RS05005	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B9057_RS05015	COG0248	Ppx GppA phosphatase
B9057_RS05020	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B9057_RS05030	COG0628	permease
B9057_RS05035	COG0442	prolyl-tRNA aminoacylation
B9057_RS05040	COG4591	ABC-type transport system involved in lipoprotein release permease component
B9057_RS05045	COG1136	(ABC) transporter
B9057_RS05055	COG2010	Cytochrome c
B9057_RS05060	COG0187	DNA topoisomerase II activity
B9057_RS05080	COG0534	Mate efflux family protein
B9057_RS05105	COG1846	Transcriptional regulator
B9057_RS05130	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B9057_RS05140	COG1278	Cold shock
B9057_RS05145	COG1393	Belongs to the ArsC family
B9057_RS05155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B9057_RS05165	COG0596	Alpha beta hydrolase
B9057_RS05195	COG0583	DNA-binding transcription factor activity
B9057_RS05200	COG0587	DNA-directed DNA polymerase activity
B9057_RS05215	COG2379	hydroxypyruvate reductase
B9057_RS05240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B9057_RS05250	COG3384	dioxygenase
B9057_RS05265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B9057_RS05285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B9057_RS05290	COG4235	cytochrome complex assembly
B9057_RS05295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9057_RS05305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B9057_RS05305	COG0446	pyridine nucleotide-disulphide oxidoreductase
B9057_RS05350	COG0840	transmembrane signaling receptor activity
B9057_RS05355	COG2962	Rard protein
B9057_RS05360	COG1611	Belongs to the LOG family
B9057_RS05370	COG5265	(ABC) transporter
B9057_RS05375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B9057_RS05390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B9057_RS05395	COG1160	GTP binding
B9057_RS05405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B9057_RS05415	COG1862	Preprotein translocase
B9057_RS05420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B9057_RS05425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B9057_RS05430	COG3737	Protein of unknown function (DUF498/DUF598)
B9057_RS05435	COG4133	protoheme IX ABC transporter activity
B9057_RS05440	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B9057_RS05445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B9057_RS05455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B9057_RS05475	COG1560	Kdo2-lipid A biosynthetic process
B9057_RS05480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B9057_RS05485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B9057_RS05510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B9057_RS05525	COG0544	peptidyl-prolyl cis-trans isomerase activity
B9057_RS05535	COG0359	binds to the 23S rRNA
B9057_RS05540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B9057_RS05545	COG0360	Binds together with S18 to 16S ribosomal RNA
B9057_RS05555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B9057_RS05580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B9057_RS05585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B9057_RS05595	COG4695	Portal protein
B9057_RS05690	COG0508	dehydrogenase complex catalyzes the overall conversion of
B9057_RS05695	COG0022	dehydrogenase e1 component
B9057_RS05695	COG0508	dehydrogenase complex catalyzes the overall conversion of
B9057_RS05700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B9057_RS05710	COG3588	fructose-bisphosphate aldolase
B9057_RS05715	COG0126	phosphoglycerate kinase activity
B9057_RS05745	COG2354	Protein conserved in bacteria
B9057_RS05750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B9057_RS05770	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B9057_RS05775	COG0271	Belongs to the BolA IbaG family
B9057_RS05780	COG1357	PFAM Pentapeptide repeats (8 copies)
B9057_RS05785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B9057_RS05790	COG0583	DNA-binding transcription factor activity
B9057_RS05800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B9057_RS05805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B9057_RS05810	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B9057_RS05830	COG1138	Cytochrome C-type biogenesis protein
B9057_RS05835	COG3088	subunit of a heme lyase
B9057_RS05840	COG1024	Enoyl-CoA hydratase
B9057_RS05845	COG0372	Belongs to the citrate synthase family
B9057_RS05850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B9057_RS05855	COG0658	competence protein
B9057_RS05855	COG2333	competence protein COMEC
B9057_RS05860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B9057_RS05865	COG0303	'Molybdopterin
B9057_RS05880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B9057_RS05895	COG0698	ribose 5-phosphate isomerase
B9057_RS05900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B9057_RS05910	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B9057_RS05920	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B9057_RS05925	COG0259	pyridoxamine-phosphate oxidase activity
B9057_RS05930	COG1278	Cold shock
B9057_RS05950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B9057_RS05975	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B9057_RS05990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B9057_RS06030	COG4974	Belongs to the 'phage' integrase family
B9057_RS06060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B9057_RS06110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B9057_RS06125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B9057_RS06135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B9057_RS06140	COG1129	ABC transporter
B9057_RS06140	COG0842	Transport permease protein
B9057_RS06145	COG0842	Transport permease protein
B9057_RS06165	COG0318	PFAM AMP-dependent synthetase and ligase
B9057_RS06170	COG1024	Enoyl-CoA hydratase
B9057_RS06175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B9057_RS06180	COG1522	sequence-specific DNA binding
B9057_RS06185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B9057_RS06190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B9057_RS06195	COG1984	allophanate hydrolase subunit 2
B9057_RS06205	COG0840	transmembrane signaling receptor activity
B9057_RS06210	COG1396	sequence-specific DNA binding
B9057_RS06230	COG2989	Protein conserved in bacteria
B9057_RS06235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B9057_RS06255	COG0433	COG0433 Predicted ATPase
B9057_RS06260	COG4536	flavin adenine dinucleotide binding
B9057_RS06265	COG4974	Belongs to the 'phage' integrase family
B9057_RS06275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B9057_RS06280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B9057_RS06290	COG5012	cobalamin binding
B9057_RS06295	COG1410	methionine synthase
B9057_RS06295	COG0646	methionine synthase
B9057_RS06305	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B9057_RS06310	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B9057_RS06315	COG0047	phosphoribosylformylglycinamidine synthase activity
B9057_RS06325	COG2204	response regulator
B9057_RS06330	COG1530	ribonuclease E activity
B9057_RS06335	COG0785	Cytochrome C biogenesis protein
B9057_RS06365	COG0114	fumarate hydratase activity
B9057_RS06375	COG2059	Chromate
B9057_RS06390	COG0604	alcohol dehydrogenase
B9057_RS06395	COG0415	Belongs to the DNA photolyase family
B9057_RS06400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B9057_RS06410	COG0494	nUDIX hydrolase
B9057_RS06420	COG3264	Mechanosensitive ion channel
B9057_RS06420	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B9057_RS06425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B9057_RS06440	COG1028	Short-chain dehydrogenase reductase Sdr
B9057_RS06450	COG0318	PFAM AMP-dependent synthetase and ligase
B9057_RS06465	COG1131	(ABC) transporter
B9057_RS06470	COG0842	Transport permease protein
B9057_RS06480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B9057_RS06485	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B9057_RS06495	COG2166	iron-sulfur cluster assembly
B9057_RS06500	COG0629	single-stranded DNA binding
B9057_RS06520	COG1196	nuclear chromosome segregation
B9057_RS06520	COG0741	lytic transglycosylase activity
B9057_RS06520	COG0739	heme binding
B9057_RS06530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B9057_RS06535	COG0528	UMP kinase activity
B9057_RS06540	COG0233	cytoplasmic translational termination
B9057_RS06545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B9057_RS06550	COG4589	Belongs to the CDS family
B9057_RS06555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B9057_RS06560	COG0750	zinc metalloprotease
B9057_RS06565	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B9057_RS06575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B9057_RS06580	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B9057_RS06590	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B9057_RS06595	COG1238	metal cluster binding
B9057_RS06600	COG0482	sulfurtransferase activity
B9057_RS06610	COG0745	RESPONSE REGULATOR receiver
B9057_RS06615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B9057_RS06625	COG0840	transmembrane signaling receptor activity
B9057_RS06635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B9057_RS06640	COG0516	GMP reductase activity
B9057_RS06640	COG0517	IMP dehydrogenase activity
B9057_RS06655	COG0837	glucose binding
B9057_RS06660	COG1609	Transcriptional regulator
B9057_RS06665	COG1653	transport
B9057_RS06670	COG1175	transmembrane transport
B9057_RS06680	COG0366	Alpha amylase catalytic
B9057_RS06685	COG3842	ATPase activity
B9057_RS06695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B9057_RS06705	COG0248	Ppx GppA phosphatase
B9057_RS06710	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B9057_RS06720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B9057_RS06740	COG3743	rRNA binding
B9057_RS06740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B9057_RS06745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B9057_RS06755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B9057_RS06760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B9057_RS06765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B9057_RS06790	COG0352	thiamine-phosphate diphosphorylase activity
B9057_RS06795	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B9057_RS06800	COG1612	heme a metabolic process
B9057_RS06805	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B9057_RS06810	COG1024	Enoyl-CoA hydratase
B9057_RS06830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B9057_RS06840	COG1309	transcriptional regulator
B9057_RS06845	COG2326	polyphosphate kinase activity
B9057_RS06850	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B9057_RS06875	COG0519	Catalyzes the synthesis of GMP from XMP
B9057_RS06875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B9057_RS06905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B9057_RS06910	COG2867	negative regulation of translational initiation
B9057_RS06915	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B9057_RS06920	COG0004	ammonium transporteR
B9057_RS06930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B9057_RS06935	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B9057_RS06935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B9057_RS06940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B9057_RS06945	COG3852	Histidine kinase
B9057_RS06950	COG2204	response regulator
B9057_RS06955	COG5000	phosphorelay sensor kinase activity
B9057_RS06960	COG2204	response regulator
B9057_RS06970	COG0569	domain protein
B9057_RS06980	COG1923	regulation of RNA biosynthetic process
B9057_RS06985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B9057_RS07025	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B9057_RS07035	COG1561	YicC-like family, N-terminal region
B9057_RS07040	COG0194	GDP metabolic process
B9057_RS07055	COG5002	protein histidine kinase activity
B9057_RS07065	COG0573	inorganic phosphate transmembrane transporter activity
B9057_RS07070	COG0581	inorganic phosphate transmembrane transporter activity
B9057_RS07075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B9057_RS07080	COG0704	Plays a role in the regulation of phosphate uptake
B9057_RS07085	COG0745	RESPONSE REGULATOR receiver
B9057_RS07090	COG0006	proline dipeptidase activity
B9057_RS07095	COG0583	DNA-binding transcription factor activity
B9057_RS07100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B9057_RS07110	COG2197	response regulator
B9057_RS07115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B9057_RS07120	COG0052	Belongs to the universal ribosomal protein uS2 family
B9057_RS07140	COG2313	pseudouridylate synthase activity
B9057_RS07155	COG1028	Short-chain dehydrogenase reductase Sdr
B9057_RS07160	COG4166	transmembrane transport
B9057_RS07180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B9057_RS07220	COG2321	neutral zinc metallopeptidase
B9057_RS07225	COG1238	metal cluster binding
B9057_RS07230	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B9057_RS07240	COG0010	Belongs to the arginase family
B9057_RS07245	COG2423	ornithine cyclodeaminase activity
B9057_RS07250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B9057_RS07255	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B9057_RS07260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B9057_RS07275	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B9057_RS07285	COG0363	glucosamine-6-phosphate deaminase activity
B9057_RS07290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B9057_RS07310	COG2099	Precorrin-6x reductase
B9057_RS07315	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B9057_RS07325	COG1797	cobyrinic acid a,c-diamide synthase activity
B9057_RS07330	COG2814	Major facilitator Superfamily
B9057_RS07340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B9057_RS07345	COG0215	cysteine-tRNA ligase activity
B9057_RS07350	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B9057_RS07355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B9057_RS07380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B9057_RS07390	COG0719	Fe-S assembly protein
B9057_RS07395	COG0396	ATPase activity
B9057_RS07405	COG0393	Putative heavy-metal-binding
B9057_RS07410	COG0719	Fe-S assembly protein
B9057_RS07420	COG1959	2 iron, 2 sulfur cluster binding
B9057_RS07425	COG2945	thiolester hydrolase activity
B9057_RS07440	COG0538	isocitrate dehydrogenase activity
B9057_RS07460	COG1217	gtp-binding protein TYPA
B9057_RS07470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B9057_RS07475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B9057_RS07490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B9057_RS07495	COG0826	peptidase U32
B9057_RS07500	COG0174	glutamine synthetase
B9057_RS07505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B9057_RS07515	COG1024	Enoyl-CoA hydratase
B9057_RS07525	COG1473	amidohydrolase
B9057_RS07540	COG4681	YaeQ
B9057_RS07550	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B9057_RS07555	COG1177	transmembrane transport
B9057_RS07565	COG3842	ATPase activity
B9057_RS07570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B9057_RS07595	COG4638	Rieske (2fe-2S)
B9057_RS07600	COG2072	flavoprotein involved in K transport
B9057_RS07605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B9057_RS07605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9057_RS07650	COG1609	Transcriptional regulator
B9057_RS07660	COG2358	TRAP transporter, solute receptor (TAXI family
B9057_RS07665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B9057_RS07795	COG2205	protein histidine kinase activity
B9057_RS07815	COG1414	Transcriptional regulator
B9057_RS07825	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B9057_RS07830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B9057_RS07850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B9057_RS07860	COG1012	belongs to the aldehyde dehydrogenase family
B9057_RS07865	COG0583	DNA-binding transcription factor activity
B9057_RS07895	COG0406	alpha-ribazole phosphatase activity
B9057_RS07905	COG0776	regulation of translation
B9057_RS07910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B9057_RS07930	COG0343	queuine tRNA-ribosyltransferase activity
B9057_RS07945	COG2151	metal-sulfur cluster biosynthetic enzyme
B9057_RS07950	COG0316	Belongs to the HesB IscA family
B9057_RS07965	COG0149	triose-phosphate isomerase activity
B9057_RS07970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B9057_RS07975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B9057_RS07980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B9057_RS07995	COG2124	cytochrome p450
B9057_RS08000	COG1522	sequence-specific DNA binding
B9057_RS08005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B9057_RS08005	COG1648	precorrin-2 dehydrogenase activity
B9057_RS08015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B9057_RS08020	COG0175	sulfate reduction
B9057_RS08035	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B9057_RS08055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B9057_RS08060	COG0416	fatty acid biosynthetic process
B9057_RS08065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B9057_RS08070	COG0776	regulation of translation
B9057_RS08090	COG0717	Belongs to the dCTP deaminase family
B9057_RS08105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B9057_RS08110	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B9057_RS08115	COG1472	Belongs to the glycosyl hydrolase 3 family
B9057_RS08125	COG0018	arginyl-trna synthetase
B9057_RS08140	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B9057_RS08155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B9057_RS08195	COG0501	Belongs to the peptidase M48B family
B9057_RS08215	COG0129	dihydroxy-acid dehydratase activity
B9057_RS08220	COG0800	Aldolase
B9057_RS08230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B9057_RS08260	COG0028	Belongs to the TPP enzyme family
B9057_RS08280	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B9057_RS08295	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9057_RS08310	COG0784	Response regulator, receiver
B9057_RS08310	COG2198	Histidine kinase
B9057_RS08310	COG5002	protein histidine kinase activity
B9057_RS08320	COG0105	UTP biosynthetic process
B9057_RS08325	COG0488	(ABC) transporter
B9057_RS08330	COG2095	MarC family integral membrane protein
B9057_RS08350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B9057_RS08365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B9057_RS08375	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B9057_RS08380	COG0010	Belongs to the arginase family
B9057_RS08390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B9057_RS08395	COG2890	protein-(glutamine-N5) methyltransferase activity
B9057_RS08405	COG2818	Glycosylase
B9057_RS08410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B9057_RS08415	COG1473	amidohydrolase
B9057_RS08420	COG3956	TIGRFAM MazG family protein
B9057_RS08425	COG1840	ABC-type Fe3 transport system, periplasmic component
B9057_RS08435	COG0488	(ABC) transporter
B9057_RS08440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B9057_RS08460	COG1960	acyl-CoA dehydrogenase activity
B9057_RS08465	COG1024	Enoyl-CoA hydratase
B9057_RS08490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B9057_RS08505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B9057_RS08515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B9057_RS08520	COG2833	Protein of unknown function (DUF455)
B9057_RS08525	COG0739	heme binding
B9057_RS08540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B9057_RS08545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B9057_RS08555	COG0860	N-Acetylmuramoyl-L-alanine amidase
B9057_RS08560	COG0436	Aminotransferase
B9057_RS08590	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B9057_RS08600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B9057_RS08615	COG0418	dihydroorotase activity
B9057_RS08620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B9057_RS08625	COG0305	Participates in initiation and elongation during chromosome replication
B9057_RS08630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B9057_RS08635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B9057_RS08640	COG1127	ABC transporter
B9057_RS08665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B9057_RS08675	COG4221	oxidoreductase activity
B9057_RS08680	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B9057_RS08700	COG0805	protein transport
B9057_RS08705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B9057_RS08710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B9057_RS08715	COG2378	regulation of single-species biofilm formation
B9057_RS08720	COG3842	ATPase activity
B9057_RS08725	COG1028	Short-chain dehydrogenase reductase Sdr
B9057_RS08735	COG0840	transmembrane signaling receptor activity
B9057_RS08740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B9057_RS08745	COG0513	Belongs to the DEAD box helicase family
B9057_RS08755	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B9057_RS08765	COG1007	ATP synthesis coupled electron transport
B9057_RS08780	COG0713	ATP synthesis coupled electron transport
B9057_RS08795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9057_RS08800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B9057_RS08830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B9057_RS08830	COG3743	rRNA binding
B9057_RS08845	COG0649	NAD binding
B9057_RS08855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9057_RS08860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B9057_RS08870	COG3706	GGDEF domain
B9057_RS08900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B9057_RS08905	COG1960	acyl-CoA dehydrogenase activity
B9057_RS08920	COG0546	phosphoglycolate phosphatase activity
B9057_RS08925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B9057_RS08950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B9057_RS08960	COG2089	acid synthase
B9057_RS08970	COG1519	Transferase
B9057_RS08980	COG1028	Short-chain dehydrogenase reductase Sdr
B9057_RS08995	COG1473	amidohydrolase
B9057_RS09000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9057_RS09005	COG0444	Belongs to the ABC transporter superfamily
B9057_RS09010	COG4608	Belongs to the ABC transporter superfamily
B9057_RS09020	COG0601	transmembrane transport
B9057_RS09025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B9057_RS09050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B9057_RS09085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B9057_RS09100	COG0308	aminopeptidase N
B9057_RS09115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B9057_RS09125	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B9057_RS09130	COG3474	cytochrome
B9057_RS09145	COG0484	heat shock protein binding
B9057_RS09180	COG0038	chloride channel
B9057_RS09185	COG0497	DNA recombination
B9057_RS09190	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B9057_RS09200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B9057_RS09205	COG0849	cell division
B9057_RS09210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B9057_RS09215	COG1181	Belongs to the D-alanine--D-alanine ligase family
B9057_RS09220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B9057_RS09230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B9057_RS09235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B9057_RS09245	COG2081	HI0933 family
B9057_RS09250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B9057_RS09255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B9057_RS09265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B9057_RS09280	COG0275	rRNA processing
B9057_RS09285	COG2001	Belongs to the MraZ family
B9057_RS09290	COG0489	protein tyrosine kinase activity
B9057_RS09300	COG1279	arginine transmembrane transporter activity
B9057_RS09325	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B9057_RS09340	COG0131	Imidazoleglycerol-phosphate dehydratase
B9057_RS09345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B9057_RS09355	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B9057_RS09365	COG2824	Alkylphosphonate utilization operon protein PhnA
B9057_RS09375	COG1132	(ABC) transporter
B9057_RS09390	COG2135	peptidase activity
B9057_RS09400	COG0737	Belongs to the 5'-nucleotidase family
B9057_RS09410	COG0167	dihydroorotate dehydrogenase activity
B9057_RS09415	COG1393	Belongs to the ArsC family
B9057_RS09420	COG0534	Mate efflux family protein
B9057_RS09445	COG1960	acyl-CoA dehydrogenase activity
B9057_RS09450	COG0625	glutathione transferase activity
B9057_RS09455	COG0183	Belongs to the thiolase family
B9057_RS09465	COG1024	Enoyl-CoA hydratase
B9057_RS09465	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9057_RS09500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B9057_RS09505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B9057_RS09510	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B9057_RS09515	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B9057_RS09520	COG0295	cytidine deaminase activity
B9057_RS09525	COG0280	phosphate acetyltransferase
B9057_RS09525	COG0281	malic enzyme
B9057_RS09535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B9057_RS09540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B9057_RS09545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B9057_RS09565	COG0481	GTPase activity
B9057_RS09575	COG4221	oxidoreductase activity
B9057_RS09580	COG0247	lactate metabolic process
B9057_RS09585	COG0277	FAD linked oxidase domain protein
B9057_RS09590	COG0277	FAD linked oxidase domain protein
B9057_RS09600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B9057_RS09610	COG0154	amidase activity
B9057_RS09625	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B9057_RS09635	COG2084	Dehydrogenase
B9057_RS09645	COG1278	Cold shock
B9057_RS09660	COG0107	imidazoleglycerol-phosphate synthase activity
B9057_RS09665	COG0140	phosphoribosyl-ATP diphosphatase activity
B9057_RS09670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B9057_RS09675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B9057_RS09680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B9057_RS09705	COG0493	'glutamate synthase
B9057_RS09710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B9057_RS09720	COG0156	8-amino-7-oxononanoate synthase activity
B9057_RS09730	COG1832	CoA-binding protein
B9057_RS09735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B9057_RS09745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B9057_RS09750	COG1201	RNA secondary structure unwinding
B9057_RS09760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B9057_RS09765	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B9057_RS09780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B9057_RS09785	COG0037	tRNA processing
B9057_RS09795	COG2885	chlorophyll binding
B9057_RS09820	COG0824	Thioesterase
B9057_RS09830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B9057_RS09840	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B9057_RS09845	COG0804	urea catabolic process
B9057_RS09850	COG0832	Belongs to the urease beta subunit family
B9057_RS09855	COG0831	urea catabolic process
B9057_RS09860	COG0829	nickel cation binding
B9057_RS09905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B9057_RS09935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B9057_RS09935	COG1648	precorrin-2 dehydrogenase activity
B9057_RS09940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B9057_RS09945	COG0243	molybdopterin cofactor binding
B9057_RS09950	COG2146	nitrite reductase [NAD(P)H] activity
B9057_RS09955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B9057_RS09960	COG1116	anion transmembrane transporter activity
B9057_RS09965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B9057_RS09970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B9057_RS09970	COG1116	anion transmembrane transporter activity
B9057_RS09975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B9057_RS09975	COG1116	anion transmembrane transporter activity
B9057_RS09980	COG3707	response regulator
B9057_RS09985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B9057_RS10065	COG3750	Belongs to the UPF0335 family
B9057_RS10075	COG1250	3-hydroxyacyl-CoA dehydrogenase
B9057_RS10075	COG1024	Enoyl-CoA hydratase
B9057_RS10090	COG2391	methyltransferase activity
B9057_RS10120	COG0745	RESPONSE REGULATOR receiver
B9057_RS10125	COG1396	sequence-specific DNA binding
B9057_RS10125	COG3800	Transcriptional regulator
B9057_RS10150	COG0410	ABC transporter
B9057_RS10155	COG0511	ligase activity, forming carbon-carbon bonds
B9057_RS10160	COG0439	Biotin carboxylase
B9057_RS10185	COG0251	oxidation-reduction process
B9057_RS10195	COG0740	serine-type endopeptidase activity
B9057_RS10200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B9057_RS10205	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
B9057_RS10220	COG1295	ribonuclease BN
B9057_RS10250	COG1072	(Pantothenic acid kinase))
B9057_RS10255	COG0033	Phosphoglucomutase
B9057_RS10275	COG0446	pyridine nucleotide-disulphide oxidoreductase
B9057_RS10290	COG1522	sequence-specific DNA binding
B9057_RS10295	COG0483	inositol monophosphate 1-phosphatase activity
B9057_RS10305	COG0583	DNA-binding transcription factor activity
B9057_RS10310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B9057_RS10330	COG0525	valine-tRNA ligase activity
B9057_RS10335	COG0318	PFAM AMP-dependent synthetase and ligase
B9057_RS10340	COG0354	folic acid binding
B9057_RS10345	COG1132	(ABC) transporter
B9057_RS10355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B9057_RS10360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B9057_RS10370	COG1492	cobalamin metabolic process
B9057_RS10385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B9057_RS10395	COG0489	protein tyrosine kinase activity
B9057_RS10395	COG3206	protein involved in exopolysaccharide biosynthesis
B9057_RS10440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B9057_RS10470	COG0642	Histidine kinase
B9057_RS10480	COG0069	glutamate synthase activity
B9057_RS10510	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B9057_RS10540	COG1376	ErfK ybiS ycfS ynhG family protein
B9057_RS10575	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B9057_RS10590	COG0463	Glycosyl transferase, family 2
B9057_RS10595	COG0625	glutathione transferase activity
B9057_RS10600	COG1970	mechanosensitive ion channel activity
B9057_RS10605	COG0686	Belongs to the AlaDH PNT family
B9057_RS10615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B9057_RS10625	COG0604	alcohol dehydrogenase
B9057_RS10655	COG0714	Associated with various cellular activities
B9057_RS10685	COG0071	Belongs to the small heat shock protein (HSP20) family
B9057_RS10690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B9057_RS10690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B9057_RS10705	COG1131	(ABC) transporter
B9057_RS10710	COG0725	ABC transporter, periplasmic molybdate-binding protein
B9057_RS10730	COG2873	o-acetylhomoserine
B9057_RS10735	COG2968	Membrane
B9057_RS10745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B9057_RS10745	COG0475	glutathione-regulated potassium exporter activity
B9057_RS10750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B9057_RS10755	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B9057_RS10775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B9057_RS10785	COG0330	HflC and HflK could
B9057_RS10800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B9057_RS10805	COG0625	glutathione transferase activity
B9057_RS10810	COG1760	l-serine dehydratase
B9057_RS10815	COG0697	spore germination
B9057_RS10835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B9057_RS10845	COG0504	CTP synthase activity
B9057_RS10850	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B9057_RS10870	COG4215	(ABC) transporter
B9057_RS10880	COG0174	glutamine synthetase
B9057_RS10885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B9057_RS10885	COG0519	Catalyzes the synthesis of GMP from XMP
B9057_RS10890	COG0174	glutamine synthetase
B9057_RS10900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B9057_RS10905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B9057_RS10910	COG1703	isobutyryl-CoA mutase activity
B9057_RS10920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B9057_RS10935	COG0738	Major facilitator superfamily
B9057_RS10940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B9057_RS10950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B9057_RS10955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B9057_RS10965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B9057_RS10970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B9057_RS10975	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B9057_RS10980	COG0356	it plays a direct role in the translocation of protons across the membrane
B9057_RS11005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B9057_RS11030	COG0778	Nitroreductase
B9057_RS11035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B9057_RS11045	COG0336	Belongs to the RNA methyltransferase TrmD family
B9057_RS11055	COG0335	large ribosomal subunit rRNA binding
B9057_RS11060	COG0254	rRNA binding
B9057_RS11065	COG0513	Belongs to the DEAD box helicase family
B9057_RS11070	COG2151	metal-sulfur cluster biosynthetic enzyme
B9057_RS11070	COG0489	protein tyrosine kinase activity
B9057_RS11075	COG4191	Histidine kinase
B9057_RS11085	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B9057_RS11095	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
B9057_RS11145	COG0375	protein maturation
B9057_RS11185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B9057_RS11190	COG3383	formate dehydrogenase (NAD+) activity
B9057_RS11210	COG3118	belongs to the thioredoxin family
B9057_RS11215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B9057_RS11220	COG1278	Cold shock
B9057_RS11235	COG3128	pkhd-type hydroxylase
B9057_RS11250	COG3046	protein related to deoxyribodipyrimidine photolyase
B9057_RS11260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B9057_RS11265	COG1234	tRNA 3'-trailer cleavage
B9057_RS11270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B9057_RS11275	COG1522	sequence-specific DNA binding
B9057_RS11290	COG4786	Flagellar basal body rod
B9057_RS11305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B9057_RS11310	COG1558	bacterial-type flagellum-dependent cell motility
B9057_RS11325	COG2197	response regulator
B9057_RS11340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B9057_RS11345	COG0443	Heat shock 70 kDa protein
B9057_RS11360	COG3257	ureidoglycine aminohydrolase activity
B9057_RS11370	COG2217	Heavy metal translocating P-type atpase
B9057_RS11380	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
B9057_RS11390	COG0181	hydroxymethylbilane synthase activity
B9057_RS11395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B9057_RS11400	COG1280	lysine exporter protein (LysE YggA)
B9057_RS11405	COG0408	coproporphyrinogen oxidase activity
B9057_RS11420	COG2813	Specifically methylates the guanine in position
B9057_RS11425	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B9057_RS11435	COG1686	Belongs to the peptidase S11 family
B9057_RS11440	COG4172	Belongs to the ABC transporter superfamily
B9057_RS11445	COG4239	(ABC) transporter, permease
B9057_RS11450	COG4174	ABC transporter (Permease)
B9057_RS11455	COG4166	transmembrane transport
B9057_RS11465	COG1605	Chorismate mutase
B9057_RS11465	COG0077	Prephenate dehydratase
B9057_RS11480	COG0072	phenylalanine-tRNA ligase activity
B9057_RS11480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B9057_RS11485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B9057_RS11490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B9057_RS11495	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B9057_RS11505	COG0469	pyruvate kinase activity
B9057_RS11535	COG0825	malonyl-CoA metabolic process
B9057_RS11555	COG2884	Cell division ATP-binding protein ftsE
B9057_RS11570	COG0019	diaminopimelate decarboxylase activity
B9057_RS11580	COG0165	Argininosuccinate lyase
B9057_RS11585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B9057_RS11590	COG1678	Uncharacterized ACR, COG1678
B9057_RS11600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B9057_RS11610	COG0521	Mo-molybdopterin cofactor biosynthetic process
B9057_RS11620	COG0540	Belongs to the ATCase OTCase family
B9057_RS11635	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B9057_RS11650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B9057_RS11655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B9057_RS11660	COG2885	chlorophyll binding
B9057_RS11670	COG0009	L-threonylcarbamoyladenylate synthase
B9057_RS11675	COG1960	acyl-CoA dehydrogenase activity
B9057_RS11715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B9057_RS11730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B9057_RS11735	COG0142	geranyltranstransferase activity
B9057_RS11745	COG2890	protein-(glutamine-N5) methyltransferase activity
B9057_RS11760	COG1028	Short-chain dehydrogenase reductase Sdr
B9057_RS11770	COG3300	MHYT domain
B9057_RS11770	COG5001	Diguanylate cyclase
B9057_RS11775	COG0314	molybdopterin synthase activity
B9057_RS11785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B9057_RS11790	COG0322	excinuclease ABC activity
B9057_RS11805	COG0616	signal peptide processing
B9057_RS11805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B9057_RS11810	COG0842	Transport permease protein
B9057_RS11815	COG1131	(ABC) transporter
B9057_RS11820	COG0159	tryptophan synthase activity
B9057_RS11830	COG0129	dihydroxy-acid dehydratase activity
B9057_RS11850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B9057_RS11860	COG2201	protein-glutamate methylesterase activity
B9057_RS11865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B9057_RS11870	COG0835	chemotaxis
B9057_RS11880	COG0835	chemotaxis
B9057_RS11935	COG0582	viral genome integration into host DNA
B9057_RS11940	COG0653	protein targeting
B9057_RS11995	COG2132	Multicopper oxidase
B9057_RS12030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B9057_RS12040	COG0583	DNA-binding transcription factor activity
B9057_RS12055	COG0028	Belongs to the TPP enzyme family
B9057_RS12075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B9057_RS12075	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B9057_RS12080	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B9057_RS12090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B9057_RS12120	COG3842	ATPase activity
B9057_RS12125	COG0395	ABC-type sugar transport system, permease component
B9057_RS12135	COG1653	transport
B9057_RS12140	COG1609	Transcriptional regulator
B9057_RS12145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B9057_RS12160	COG3842	ATPase activity
B9057_RS12165	COG0395	ABC-type sugar transport system, permease component
B9057_RS12170	COG1175	transmembrane transport
B9057_RS12180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B9057_RS12185	COG4989	oxidoreductase activity
B9057_RS12195	COG2188	Transcriptional regulator
B9057_RS12200	COG0673	inositol 2-dehydrogenase activity
B9057_RS12205	COG0662	Cupin 2, conserved barrel domain protein
B9057_RS12230	COG4176	ABC-type proline glycine betaine transport system permease component
B9057_RS12250	COG1802	Transcriptional regulator
B9057_RS12255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B9057_RS12265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B9057_RS12270	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
B9057_RS12275	COG1228	amidohydrolase
B9057_RS12310	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B9057_RS12315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B9057_RS12320	COG1280	lysine exporter protein (LysE YggA)
B9057_RS12345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B9057_RS12360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B9057_RS12375	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B9057_RS12410	COG0559	Belongs to the binding-protein-dependent transport system permease family
B9057_RS12455	COG0584	glycerophosphoryl diester phosphodiesterase
B9057_RS12465	COG2154	pterin-4-alpha-carbinolamine dehydratase
B9057_RS12470	COG0668	transmembrane transport
B9057_RS12475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B9057_RS12475	COG0678	peroxiredoxin activity
B9057_RS12485	COG0742	ribosomal rna small subunit methyltransferase
B9057_RS12500	COG0024	Methionine aminopeptidase
B9057_RS12505	COG1489	DNA binding
B9057_RS12510	COG1058	Belongs to the CinA family
B9057_RS12510	COG1546	Belongs to the CinA family
B9057_RS12535	COG1230	cation diffusion facilitator family transporter
B9057_RS12540	COG0583	DNA-binding transcription factor activity
B9057_RS12545	COG0446	pyridine nucleotide-disulphide oxidoreductase
B9057_RS12545	COG1902	pentaerythritol trinitrate reductase activity
B9057_RS12565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B9057_RS12580	COG1652	LysM domain
B9057_RS12585	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B9057_RS12595	COG2423	ornithine cyclodeaminase activity
B9057_RS12605	COG1671	Belongs to the UPF0178 family
B9057_RS12610	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B9057_RS12615	COG0679	Auxin Efflux Carrier
B9057_RS12620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B9057_RS12625	COG0799	negative regulation of ribosome biogenesis
B9057_RS12635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B9057_RS12640	COG0066	3-isopropylmalate dehydratase activity
B9057_RS12655	COG0473	3-isopropylmalate dehydrogenase activity
B9057_RS12660	COG0697	spore germination
B9057_RS12685	COG0348	domain, Protein
B9057_RS12690	COG2010	Cytochrome c
B9057_RS12715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B9057_RS12720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B9057_RS12735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B9057_RS12740	COG0288	reversible hydration of carbon dioxide
B9057_RS12750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B9057_RS12755	COG0791	NLP P60 protein
B9057_RS12770	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B9057_RS12790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B9057_RS12800	COG0793	Belongs to the peptidase S41A family
B9057_RS12805	COG1051	belongs to the nudix hydrolase family
B9057_RS12810	COG2951	lytic endotransglycosylase activity
B9057_RS12815	COG0557	exoribonuclease II activity
B9057_RS12820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B9057_RS12840	COG2171	N-acyltransferase activity
B9057_RS12850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B9057_RS12865	COG3830	Belongs to the UPF0237 family
B9057_RS12865	COG0560	Phosphoserine phosphatase
B9057_RS12875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B9057_RS12880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B9057_RS12885	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B9057_RS12895	COG0183	Belongs to the thiolase family
B9057_RS12900	COG3022	response to hydroperoxide
B9057_RS12905	COG0514	ATP-dependent DNA helicase (RecQ)
B9057_RS12910	COG2835	tetraacyldisaccharide 4'-kinase activity
B9057_RS12930	COG0745	RESPONSE REGULATOR receiver
B9057_RS12945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B9057_RS12970	COG0582	viral genome integration into host DNA
B9057_RS12985	COG0582	viral genome integration into host DNA
B9057_RS13050	COG2308	Evidence 4 Homologs of previously reported genes of
B9057_RS13055	COG1609	Transcriptional regulator
B9057_RS13090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B9057_RS13105	COG1194	a g-specific adenine glycosylase
B9057_RS13115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B9057_RS13125	COG1519	Transferase
B9057_RS13135	COG3769	mannosylglycerate metabolic process
B9057_RS13140	COG1215	transferase activity, transferring glycosyl groups
B9057_RS13150	COG0312	modulator of DNA gyrase
B9057_RS13160	COG0300	oxidoreductase activity
B9057_RS13165	COG1024	Enoyl-CoA hydratase
B9057_RS13175	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B9057_RS13200	COG0495	leucyl-tRNA aminoacylation
B9057_RS13220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B9057_RS13225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B9057_RS13235	COG0625	glutathione transferase activity
B9057_RS13260	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B9057_RS13270	COG4143	(ABC) transporter
B9057_RS13275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B9057_RS13290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B9057_RS13305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B9057_RS13310	COG0142	geranyltranstransferase activity
B9057_RS13315	COG1722	exodeoxyribonuclease VII activity
B9057_RS13320	COG0123	including yeast histone deacetylase and acetoin utilization protein
B9057_RS13325	COG0745	RESPONSE REGULATOR receiver
B9057_RS13330	COG1846	Transcriptional regulator
B9057_RS13335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B9057_RS13355	COG0348	domain, Protein
B9057_RS13355	COG3901	Regulator of nitric oxide reductase transcription
B9057_RS13405	COG1131	(ABC) transporter
B9057_RS13420	COG1116	anion transmembrane transporter activity
B9057_RS13445	COG0784	Response regulator, receiver
B9057_RS13445	COG2198	Histidine kinase
B9057_RS13445	COG5002	protein histidine kinase activity
B9057_RS13455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B9057_RS13465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B9057_RS13490	COG1968	undecaprenyl-diphosphatase activity
B9057_RS13505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B9057_RS13525	COG1137	ATPase activity
B9057_RS13530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B9057_RS13535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B9057_RS13575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B9057_RS13595	COG0443	Heat shock 70 kDa protein
B9057_RS13605	COG2003	Belongs to the UPF0758 family
B9057_RS13610	COG2885	chlorophyll binding
B9057_RS13620	COG0653	protein targeting
B9057_RS13625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B9057_RS13630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B9057_RS13635	COG0494	nUDIX hydrolase
B9057_RS13640	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B9057_RS13655	COG0779	Required for maturation of 30S ribosomal subunits
B9057_RS13670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B9057_RS13685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B9057_RS13690	COG1040	competence protein
B9057_RS13720	COG3034	peptidoglycan biosynthetic process
B9057_RS13725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B9057_RS13735	COG0494	nUDIX hydrolase
B9057_RS13745	COG0494	nUDIX hydrolase
B9057_RS13755	COG0137	argininosuccinate synthase activity
B9057_RS13775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B9057_RS13780	COG0281	malic enzyme
B9057_RS13780	COG0280	phosphate acetyltransferase
B9057_RS13785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B9057_RS13790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B9057_RS13795	COG1420	regulation of RNA biosynthetic process
B9057_RS13800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B9057_RS13805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B9057_RS13810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B9057_RS13825	COG0357	Ribosomal RNA small subunit methyltransferase G
B9057_RS13830	COG0445	tRNA wobble uridine modification
B9057_RS13835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B9057_RS13840	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B9057_RS13845	COG1981	membrane
B9057_RS13850	COG0424	maF-like protein
B9057_RS13855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B9057_RS13860	COG0237	dephospho-CoA kinase activity
B9057_RS13865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B9057_RS13870	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B9057_RS13895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B9057_RS13905	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B9057_RS13920	COG2887	Belongs to the helicase family. UvrD subfamily
B9057_RS13925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B9057_RS13930	COG3178	'Phosphotransferase
B9057_RS13935	COG0802	atpase or kinase
B9057_RS13950	COG1999	signal sequence binding
B9057_RS13955	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B9057_RS13960	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
B9057_RS13965	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B9057_RS13985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B9057_RS13990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B9057_RS14015	COG1959	2 iron, 2 sulfur cluster binding
B9057_RS14080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B9057_RS14085	COG4134	Bacterial extracellular solute-binding protein
B9057_RS14090	COG4135	transport system, permease component
B9057_RS14095	COG4136	ATPase activity
B9057_RS14100	COG1309	transcriptional regulator
B9057_RS14130	COG1360	Flagellar Motor Protein
B9057_RS14170	COG2226	methyltransferase
B9057_RS14175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B9057_RS14185	COG0268	Binds directly to 16S ribosomal RNA
B9057_RS14190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B9057_RS14230	COG0392	lysyltransferase activity
B9057_RS14230	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B9057_RS14240	COG0671	phosphoesterase, PA-phosphatase related
B9057_RS14285	COG0586	Pfam SNARE associated Golgi protein
B9057_RS14290	COG0392	lysyltransferase activity
B9057_RS14290	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B9057_RS14295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B9057_RS14305	COG0598	Magnesium transport protein CorA
B9057_RS14325	COG0586	Pfam SNARE associated Golgi protein
B9057_RS14345	COG2205	protein histidine kinase activity
B9057_RS14360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B9057_RS14370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B9057_RS14375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B9057_RS14405	COG1752	Esterase of the alpha-beta hydrolase superfamily
B9057_RS14415	COG0583	DNA-binding transcription factor activity
B9057_RS14440	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B9057_RS14445	COG0517	IMP dehydrogenase activity
B9057_RS14450	COG1758	RNA polymerase activity
B9057_RS14460	COG0484	heat shock protein binding
B9057_RS14465	COG0501	Belongs to the peptidase M48B family
B9057_RS14470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B9057_RS14490	COG0071	Belongs to the small heat shock protein (HSP20) family
B9057_RS14500	COG0071	Belongs to the small heat shock protein (HSP20) family
B9057_RS14505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B9057_RS14535	COG1196	nuclear chromosome segregation
B9057_RS14535	COG0741	lytic transglycosylase activity
B9057_RS14535	COG0739	heme binding
B9057_RS14555	COG1196	nuclear chromosome segregation
B9057_RS14555	COG0741	lytic transglycosylase activity
B9057_RS14555	COG0739	heme binding
B9057_RS14575	COG2948	multi-organism process
B9057_RS14580	COG4962	Type ii secretion system protein e
B9057_RS14600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B9057_RS14615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B9057_RS14625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B9057_RS14630	COG0842	Transport permease protein
B9057_RS14630	COG1129	ABC transporter
B9057_RS14635	COG0842	Transport permease protein
B9057_RS14775	COG1414	Transcriptional regulator
B9057_RS14780	COG1475	DNA binding
B9057_RS14800	COG2188	Transcriptional regulator
B9057_RS14825	COG0175	sulfate reduction
B9057_RS14840	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9057_RS14845	COG1129	ABC transporter
B9057_RS14875	COG1454	alcohol dehydrogenase
B9057_RS14885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B9057_RS14895	COG1349	DNA-binding transcription factor activity
B9057_RS14900	COG0149	triose-phosphate isomerase activity
B9057_RS14915	COG2376	Dihydroxyacetone kinase
B9057_RS14925	COG3959	Transketolase, thiamine diphosphate binding domain
B9057_RS14930	COG3958	Transketolase
B9057_RS14935	COG1028	Short-chain dehydrogenase reductase Sdr
B9057_RS14940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B9057_RS14950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B9057_RS14955	COG0583	DNA-binding transcription factor activity
B9057_RS14960	COG0179	Fumarylacetoacetate (FAA) hydrolase
B9057_RS14990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B9057_RS14995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B9057_RS15015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B9057_RS15020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B9057_RS15025	COG2089	acid synthase
B9057_RS15035	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B9057_RS15040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B9057_RS15070	COG1216	Glycosyl transferase, family 2
B9057_RS15090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B9057_RS15095	COG0662	Cupin 2, conserved barrel domain protein
B9057_RS15095	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B9057_RS15100	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B9057_RS15105	COG1088	dTDP-glucose 4,6-dehydratase activity
B9057_RS15110	COG1091	dTDP-4-dehydrorhamnose reductase activity
B9057_RS15125	COG2771	luxR family
B9057_RS15145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B9057_RS15155	COG2755	lipolytic protein G-D-S-L family
B9057_RS15155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B9057_RS15165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B9057_RS15185	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B9057_RS15205	COG2391	methyltransferase activity
B9057_RS15245	COG0183	Belongs to the thiolase family
B9057_RS15250	COG0778	Nitroreductase
B9057_RS15250	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B9057_RS15255	COG1268	BioY protein
B9057_RS15260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B9057_RS15265	COG1122	ATPase activity
B9057_RS15270	COG1414	Transcriptional regulator
B9057_RS15275	COG1475	DNA binding
B9057_RS15280	COG1192	Involved in chromosome partitioning
B9057_RS15285	COG3284	Transcriptional regulator
B9057_RS15285	COG3284	Transcriptional regulator
B9057_RS15290	COG1012	belongs to the aldehyde dehydrogenase family
B9057_RS15305	COG1802	Transcriptional regulator
B9057_RS15310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B9057_RS15320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B9057_RS15325	COG0517	IMP dehydrogenase activity
B9057_RS15325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B9057_RS15335	COG0745	RESPONSE REGULATOR receiver
B9057_RS15340	COG2176	DNA-directed DNA polymerase activity
B9057_RS15340	COG5002	protein histidine kinase activity
B9057_RS15355	COG1215	transferase activity, transferring glycosyl groups
B9057_RS15390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B9057_RS15410	COG2183	response to ionizing radiation
B9057_RS15415	COG0252	asparaginase activity
B9057_RS15440	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B9057_RS15450	COG0277	FAD linked oxidase domain protein
B9057_RS15465	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B9057_RS15470	COG2186	Transcriptional regulator
B9057_RS15505	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B9057_RS15505	COG3608	succinylglutamate desuccinylase aspartoacylase
B9057_RS15515	COG2211	Major facilitator Superfamily
B9057_RS15530	COG0183	Belongs to the thiolase family
B9057_RS15555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B9057_RS15575	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9057_RS15585	COG0673	inositol 2-dehydrogenase activity
B9057_RS15590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B9057_RS15595	COG3962	Belongs to the TPP enzyme family
B9057_RS15610	COG3718	enzyme involved in inositol metabolism
B9057_RS15625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B9057_RS15630	COG0673	inositol 2-dehydrogenase activity
B9057_RS15640	COG0673	inositol 2-dehydrogenase activity
B9057_RS15655	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B9057_RS15660	COG0511	ligase activity, forming carbon-carbon bonds
B9057_RS15665	COG0439	Biotin carboxylase
B9057_RS15675	COG1984	allophanate hydrolase subunit 2
B9057_RS15680	COG1879	ABC-type sugar transport system periplasmic component
B9057_RS15685	COG1129	ABC transporter
B9057_RS15690	COG1172	Belongs to the binding-protein-dependent transport system permease family
B9057_RS15700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B9057_RS15715	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B9057_RS15725	COG1595	DNA-templated transcription, initiation
B9057_RS15755	COG3386	PFAM SMP-30 Gluconolaconase
B9057_RS15760	COG0800	Aldolase
B9057_RS15765	COG3734	2-keto-3-deoxy-galactonokinase
B9057_RS15785	COG0129	dihydroxy-acid dehydratase activity
B9057_RS15790	COG4214	carbohydrate transport
B9057_RS15810	COG4702	Belongs to the UPF0303 family
B9057_RS15835	COG3901	Regulator of nitric oxide reductase transcription
B9057_RS15835	COG0348	domain, Protein
B9057_RS15885	COG0714	Associated with various cellular activities
B9057_RS15895	COG2010	Cytochrome c
B9057_RS15905	COG3794	PFAM blue (type 1) copper domain protein
B9057_RS15940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B9057_RS15975	COG1012	belongs to the aldehyde dehydrogenase family
B9057_RS15980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B9057_RS15995	COG1196	nuclear chromosome segregation
B9057_RS15995	COG0741	lytic transglycosylase activity
B9057_RS15995	COG0739	heme binding
B9057_RS16045	COG1742	UPF0060 membrane protein
B9057_RS16050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B9057_RS16050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B9057_RS16060	COG2132	Multicopper oxidase
B9057_RS16065	COG2010	Cytochrome c
B9057_RS16105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B9057_RS16110	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B9057_RS16130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B9057_RS16135	COG4235	cytochrome complex assembly
B9057_RS16140	COG3088	subunit of a heme lyase
B9057_RS16145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B9057_RS16150	COG1138	Cytochrome C-type biogenesis protein
B9057_RS16185	COG2132	Multicopper oxidase
B9057_RS16225	COG1230	cation diffusion facilitator family transporter
B9057_RS16240	COG0789	Transcriptional regulator
B9057_RS16245	COG1999	signal sequence binding
B9057_RS16255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B9057_RS16255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B9057_RS16265	COG1999	signal sequence binding
B9057_RS16290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B9057_RS16315	COG2010	Cytochrome c
B9057_RS16330	COG2132	Multicopper oxidase
B9057_RS16340	COG1321	iron dependent repressor
B9057_RS16345	COG2132	Multicopper oxidase
B9057_RS16360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B9057_RS16365	COG1192	Involved in chromosome partitioning
B9057_RS16475	COG3831	ATPase activity
B9057_RS16525	COG1129	ABC transporter
B9057_RS16535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B9057_RS16565	COG0604	alcohol dehydrogenase
B9057_RS16595	COG2948	multi-organism process
B9057_RS16615	COG0739	heme binding
B9057_RS16615	COG0741	lytic transglycosylase activity
B9057_RS16615	COG1196	nuclear chromosome segregation
B9057_RS16625	COG3451	type IV secretory pathway VirB4
B9057_RS16875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity