locus-tag	class	description
OCA4_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OCA4_RS00015	COG2852	Protein conserved in bacteria
OCA4_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OCA4_RS00030	COG1741	Belongs to the pirin family
OCA4_RS00045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OCA4_RS00050	COG0728	peptidoglycan biosynthetic process
OCA4_RS00055	COG0180	Tryptophanyl-tRNA synthetase
OCA4_RS00060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
OCA4_RS00065	COG1214	PFAM Peptidase M22, glycoprotease
OCA4_RS00070	COG0456	acetyltransferase
OCA4_RS00080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OCA4_RS00085	COG1702	phosphate starvation-inducible protein PhoH
OCA4_RS00090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OCA4_RS00095	COG1253	flavin adenine dinucleotide binding
OCA4_RS00100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
OCA4_RS00105	COG1396	sequence-specific DNA binding
OCA4_RS00110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OCA4_RS00120	COG0779	Required for maturation of 30S ribosomal subunits
OCA4_RS00135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OCA4_RS00140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OCA4_RS00145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OCA4_RS00150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OCA4_RS00155	COG1185	polyribonucleotide nucleotidyltransferase activity
OCA4_RS00165	COG0583	DNA-binding transcription factor activity
OCA4_RS00175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OCA4_RS00185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OCA4_RS00205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OCA4_RS00210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OCA4_RS00215	COG2226	methyltransferase
OCA4_RS00220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OCA4_RS00225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OCA4_RS00230	COG0756	dUTP diphosphatase activity
OCA4_RS00235	COG2205	protein histidine kinase activity
OCA4_RS00240	COG3178	'Phosphotransferase
OCA4_RS00250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OCA4_RS00260	COG1074	ATP-dependent DNA helicase activity
OCA4_RS00275	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OCA4_RS00280	COG0159	tryptophan synthase activity
OCA4_RS00285	COG0133	tryptophan synthase activity
OCA4_RS00290	COG0135	phosphoribosylanthranilate isomerase activity
OCA4_RS00300	COG0776	regulation of translation
OCA4_RS00305	COG0616	signal peptide processing
OCA4_RS00310	COG0539	negative regulation of cytoplasmic translation
OCA4_RS00320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OCA4_RS00335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OCA4_RS00350	COG0071	Belongs to the small heat shock protein (HSP20) family
OCA4_RS00360	COG0129	dihydroxy-acid dehydratase activity
OCA4_RS00365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OCA4_RS00370	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
OCA4_RS00375	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
OCA4_RS00380	COG1137	ATPase activity
OCA4_RS00385	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
OCA4_RS00395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OCA4_RS00400	COG0058	SHG alpha-glucan phosphorylase activity
OCA4_RS00415	COG3447	MASE1 domain protein
OCA4_RS00415	COG5001	Diguanylate cyclase
OCA4_RS00415	COG5002	protein histidine kinase activity
OCA4_RS00430	COG1968	undecaprenyl-diphosphatase activity
OCA4_RS00450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OCA4_RS00455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OCA4_RS00460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OCA4_RS00465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OCA4_RS00470	COG0072	phenylalanine-tRNA ligase activity
OCA4_RS00470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OCA4_RS00485	COG0583	DNA-binding transcription factor activity
OCA4_RS00490	COG0747	negative chemotaxis
OCA4_RS00500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OCA4_RS00510	COG2267	carboxylic ester hydrolase activity
OCA4_RS00530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OCA4_RS00545	COG0588	phosphoglycerate mutase activity
OCA4_RS00550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OCA4_RS00555	COG0284	orotidine-5'-phosphate decarboxylase activity
OCA4_RS00565	COG3963	phosphatidate phosphatase activity
OCA4_RS00575	COG0443	Heat shock 70 kDa protein
OCA4_RS00585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OCA4_RS00590	COG1420	regulation of RNA biosynthetic process
OCA4_RS00595	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OCA4_RS00600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OCA4_RS00605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OCA4_RS00615	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OCA4_RS00620	COG0792	nuclease activity
OCA4_RS00625	COG0189	ligase activity
OCA4_RS00655	COG1072	(Pantothenic acid kinase))
OCA4_RS00660	COG0140	phosphoribosyl-ATP diphosphatase activity
OCA4_RS00665	COG0107	imidazoleglycerol-phosphate synthase activity
OCA4_RS00670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OCA4_RS00675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OCA4_RS00685	COG0131	Imidazoleglycerol-phosphate dehydratase
OCA4_RS00690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OCA4_RS00695	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OCA4_RS00705	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
OCA4_RS00715	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
OCA4_RS00720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OCA4_RS00725	COG0237	dephospho-CoA kinase activity
OCA4_RS00730	COG0424	maF-like protein
OCA4_RS00735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OCA4_RS00740	COG1981	membrane
OCA4_RS00745	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OCA4_RS00750	COG1396	sequence-specific DNA binding
OCA4_RS00760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OCA4_RS00780	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
OCA4_RS00785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OCA4_RS00790	COG1331	Highly conserved protein containing a thioredoxin domain
OCA4_RS00795	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OCA4_RS00800	COG0445	tRNA wobble uridine modification
OCA4_RS00805	COG0357	Ribosomal RNA small subunit methyltransferase G
OCA4_RS00835	COG0495	leucyl-tRNA aminoacylation
OCA4_RS00840	COG4251	negative regulation of phosphorylation
OCA4_RS00840	COG3706	GGDEF domain
OCA4_RS00840	COG2203	Gaf domain
OCA4_RS00840	COG5001	Diguanylate cyclase
OCA4_RS00845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OCA4_RS00855	COG0745	RESPONSE REGULATOR receiver
OCA4_RS00860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OCA4_RS00875	COG1674	ftsk spoiiie
OCA4_RS00880	COG0436	Aminotransferase
OCA4_RS00885	COG0004	ammonium transporteR
OCA4_RS00890	COG0347	Belongs to the P(II) protein family
OCA4_RS00895	COG1946	Acyl-CoA thioesterase
OCA4_RS00900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OCA4_RS00905	COG2835	tetraacyldisaccharide 4'-kinase activity
OCA4_RS00915	COG3118	belongs to the thioredoxin family
OCA4_RS00930	COG0432	Pfam Uncharacterised protein family UPF0047
OCA4_RS00945	COG0405	Gamma-glutamyltransferase
OCA4_RS00955	COG0138	bifunctional purine biosynthesis protein purh
OCA4_RS00980	COG1376	ErfK ybiS ycfS ynhG family protein
OCA4_RS00985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OCA4_RS00995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OCA4_RS01000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OCA4_RS01030	COG0583	DNA-binding transcription factor activity
OCA4_RS01055	COG4221	oxidoreductase activity
OCA4_RS01075	COG1872	DUF167
OCA4_RS01080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OCA4_RS01085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OCA4_RS01090	COG1247	-acetyltransferase
OCA4_RS01100	COG1217	gtp-binding protein TYPA
OCA4_RS01110	COG2154	pterin-4-alpha-carbinolamine dehydratase
OCA4_RS01125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OCA4_RS01135	COG0671	phosphoesterase, PA-phosphatase related
OCA4_RS01140	COG0137	argininosuccinate synthase activity
OCA4_RS01180	COG0730	response to heat
OCA4_RS01185	COG0318	PFAM AMP-dependent synthetase and ligase
OCA4_RS01190	COG0477	Major facilitator Superfamily
OCA4_RS01195	COG0473	3-isopropylmalate dehydrogenase activity
OCA4_RS01205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OCA4_RS01210	COG0288	reversible hydration of carbon dioxide
OCA4_RS01215	COG2301	Belongs to the HpcH HpaI aldolase family
OCA4_RS01220	COG0066	3-isopropylmalate dehydratase activity
OCA4_RS01235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OCA4_RS01245	COG0335	large ribosomal subunit rRNA binding
OCA4_RS01250	COG0336	Belongs to the RNA methyltransferase TrmD family
OCA4_RS01255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OCA4_RS01260	COG0228	four-way junction DNA binding
OCA4_RS01265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OCA4_RS01280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OCA4_RS01285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OCA4_RS01290	COG0564	pseudouridine synthase activity
OCA4_RS01295	COG0552	protein localization to endoplasmic reticulum
OCA4_RS01300	COG2917	probably involved in intracellular septation
OCA4_RS01310	COG4191	Histidine kinase
OCA4_RS01315	COG1595	DNA-templated transcription, initiation
OCA4_RS01335	COG3794	PFAM blue (type 1) copper domain protein
OCA4_RS01390	COG2151	metal-sulfur cluster biosynthetic enzyme
OCA4_RS01405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OCA4_RS01405	COG3453	Protein conserved in bacteria
OCA4_RS01415	COG4974	Belongs to the 'phage' integrase family
OCA4_RS01435	COG0798	PFAM Bile acid sodium symporter
OCA4_RS01440	COG0431	NADPH-dependent FMN reductase
OCA4_RS01535	COG5489	Protein of unknown function (DUF736)
OCA4_RS01565	COG1192	Involved in chromosome partitioning
OCA4_RS01590	COG0741	lytic transglycosylase activity
OCA4_RS01610	COG4962	Type ii secretion system protein e
OCA4_RS01625	COG3451	type IV secretory pathway VirB4
OCA4_RS01640	COG3846	protein secretion by the type IV secretion system
OCA4_RS01655	COG2948	multi-organism process
OCA4_RS01665	COG0583	DNA-binding transcription factor activity
OCA4_RS01675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OCA4_RS01685	COG2205	protein histidine kinase activity
OCA4_RS01690	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
OCA4_RS01695	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
OCA4_RS01700	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
OCA4_RS01755	COG0071	Belongs to the small heat shock protein (HSP20) family
OCA4_RS01760	COG0071	Belongs to the small heat shock protein (HSP20) family
OCA4_RS01765	COG3093	addiction module antidote protein HigA
OCA4_RS01785	COG0210	DNA helicase
OCA4_RS01825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OCA4_RS01880	COG1902	pentaerythritol trinitrate reductase activity
OCA4_RS01885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OCA4_RS01905	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
OCA4_RS01925	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OCA4_RS01930	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
OCA4_RS01935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OCA4_RS01940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OCA4_RS01960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OCA4_RS01970	COG0735	belongs to the Fur family
OCA4_RS01975	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OCA4_RS01990	COG0142	geranyltranstransferase activity
OCA4_RS01995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OCA4_RS02000	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OCA4_RS02015	COG5001	Diguanylate cyclase
OCA4_RS02015	COG3300	MHYT domain
OCA4_RS02025	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
OCA4_RS02045	COG0154	amidase activity
OCA4_RS02055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OCA4_RS02070	COG2890	protein-(glutamine-N5) methyltransferase activity
OCA4_RS02075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OCA4_RS02080	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
OCA4_RS02090	COG0527	aspartate kinase activity
OCA4_RS02100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OCA4_RS02115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OCA4_RS02120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OCA4_RS02125	COG1040	competence protein
OCA4_RS02130	COG2226	methyltransferase
OCA4_RS02135	COG0494	nUDIX hydrolase
OCA4_RS02140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OCA4_RS02145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OCA4_RS02150	COG0653	protein targeting
OCA4_RS02160	COG3034	peptidoglycan biosynthetic process
OCA4_RS02165	COG0825	malonyl-CoA metabolic process
OCA4_RS02170	COG4974	Belongs to the 'phage' integrase family
OCA4_RS02180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OCA4_RS02185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OCA4_RS02190	COG4536	flavin adenine dinucleotide binding
OCA4_RS02235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OCA4_RS02310	COG0069	glutamate synthase activity
OCA4_RS02315	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
OCA4_RS02330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OCA4_RS02340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OCA4_RS02345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OCA4_RS02395	COG0640	Transcriptional regulator
OCA4_RS02410	COG0798	PFAM Bile acid sodium symporter
OCA4_RS02415	COG0431	NADPH-dependent FMN reductase
OCA4_RS02435	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OCA4_RS02445	COG0789	Transcriptional regulator
OCA4_RS02465	COG0793	Belongs to the peptidase S41A family
OCA4_RS02470	COG5489	Protein of unknown function (DUF736)
OCA4_RS02525	COG0741	lytic transglycosylase activity
OCA4_RS02540	COG1937	Protein conserved in bacteria
OCA4_RS02585	COG0456	acetyltransferase
OCA4_RS02585	COG1214	PFAM Peptidase M22, glycoprotease
OCA4_RS02600	COG2372	response to copper ion
OCA4_RS02635	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OCA4_RS02655	COG1595	DNA-templated transcription, initiation
OCA4_RS02665	COG0583	DNA-binding transcription factor activity
OCA4_RS02680	COG4962	Type ii secretion system protein e
OCA4_RS02695	COG3451	type IV secretory pathway VirB4
OCA4_RS02710	COG3846	protein secretion by the type IV secretion system
OCA4_RS02715	COG3701	Conjugal transfer protein
OCA4_RS02745	COG2003	Belongs to the UPF0758 family
OCA4_RS02750	COG0024	Methionine aminopeptidase
OCA4_RS02755	COG1511	domain protein
OCA4_RS02755	COG3264	Mechanosensitive ion channel
OCA4_RS02760	COG3263	regulation of cellular component size
OCA4_RS02765	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
OCA4_RS02770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OCA4_RS02780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OCA4_RS02785	COG4149	molybdate abc transporter
OCA4_RS02790	COG0725	ABC transporter, periplasmic molybdate-binding protein
OCA4_RS02810	COG3422	double-strand break repair
OCA4_RS02820	COG0481	GTPase activity
OCA4_RS02825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OCA4_RS02830	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OCA4_RS02830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OCA4_RS02840	COG0642	Histidine kinase
OCA4_RS02845	COG0745	RESPONSE REGULATOR receiver
OCA4_RS02855	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
OCA4_RS02875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OCA4_RS02880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OCA4_RS02880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OCA4_RS02890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OCA4_RS02895	COG1643	Atp-dependent helicase
OCA4_RS02910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OCA4_RS02915	COG2188	Transcriptional regulator
OCA4_RS02945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OCA4_RS02950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
OCA4_RS02960	COG2855	membrane
OCA4_RS02965	COG1522	sequence-specific DNA binding
OCA4_RS02970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OCA4_RS02980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OCA4_RS02985	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OCA4_RS02990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OCA4_RS02995	COG2223	nitrite transmembrane transporter activity
OCA4_RS03005	COG0242	peptide deformylase activity
OCA4_RS03010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OCA4_RS03015	COG0101	tRNA pseudouridine synthase activity
OCA4_RS03025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OCA4_RS03030	COG2171	N-acyltransferase activity
OCA4_RS03040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OCA4_RS03050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OCA4_RS03055	COG0706	membrane insertase activity
OCA4_RS03060	COG0594	ribonuclease P activity
OCA4_RS03065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
OCA4_RS03070	COG3852	Histidine kinase
OCA4_RS03090	COG0747	negative chemotaxis
OCA4_RS03100	COG0789	Transcriptional regulator
OCA4_RS03105	COG2217	Heavy metal translocating P-type atpase
OCA4_RS03115	COG0154	amidase activity
OCA4_RS03130	COG0601	transmembrane transport
OCA4_RS03140	COG0444	Belongs to the ABC transporter superfamily
OCA4_RS03145	COG4608	Belongs to the ABC transporter superfamily
OCA4_RS03155	COG2080	2 iron, 2 sulfur cluster binding
OCA4_RS03160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OCA4_RS03160	COG2010	Cytochrome c
OCA4_RS03170	COG5001	Diguanylate cyclase
OCA4_RS03190	COG1414	Transcriptional regulator
OCA4_RS03225	COG4585	Histidine kinase
OCA4_RS03230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OCA4_RS03235	COG1132	(ABC) transporter
OCA4_RS03250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OCA4_RS03250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OCA4_RS03275	COG1028	Short-chain dehydrogenase reductase Sdr
OCA4_RS03310	COG0583	DNA-binding transcription factor activity
OCA4_RS03340	COG0154	amidase activity
OCA4_RS03375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OCA4_RS03380	COG1704	LemA family
OCA4_RS03460	COG0582	viral genome integration into host DNA
OCA4_RS03470	COG0183	Belongs to the thiolase family
OCA4_RS03475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OCA4_RS03490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OCA4_RS03495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OCA4_RS03505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
OCA4_RS03510	COG3474	cytochrome
OCA4_RS03515	COG4166	transmembrane transport
OCA4_RS03520	COG4166	transmembrane transport
OCA4_RS03525	COG4174	ABC transporter (Permease)
OCA4_RS03530	COG4239	(ABC) transporter, permease
OCA4_RS03535	COG4172	Belongs to the ABC transporter superfamily
OCA4_RS03540	COG0791	NLP P60 protein
OCA4_RS03545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OCA4_RS03580	COG4964	Belongs to the GSP D family
OCA4_RS03610	COG1278	Cold shock
OCA4_RS03615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OCA4_RS03620	COG0513	Belongs to the DEAD box helicase family
OCA4_RS03640	COG0784	Response regulator, receiver
OCA4_RS03660	COG0628	permease
OCA4_RS03665	COG1376	ErfK ybiS ycfS ynhG family protein
OCA4_RS03675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OCA4_RS03685	COG0175	sulfate reduction
OCA4_RS03695	COG1648	precorrin-2 dehydrogenase activity
OCA4_RS03695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OCA4_RS03700	COG0175	sulfate reduction
OCA4_RS03705	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
OCA4_RS03710	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
OCA4_RS03715	COG4208	sulfate ABC transporter
OCA4_RS03720	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OCA4_RS03730	COG1028	Short-chain dehydrogenase reductase Sdr
OCA4_RS03745	COG0318	PFAM AMP-dependent synthetase and ligase
OCA4_RS03755	COG1132	(ABC) transporter
OCA4_RS03765	COG0140	phosphoribosyl-ATP diphosphatase activity
OCA4_RS03770	COG1238	metal cluster binding
OCA4_RS03780	COG3706	GGDEF domain
OCA4_RS03795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OCA4_RS03810	COG1802	Transcriptional regulator
OCA4_RS03815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OCA4_RS03825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OCA4_RS03830	COG4336	lyase activity
OCA4_RS03835	COG0405	Gamma-glutamyltransferase
OCA4_RS03840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OCA4_RS03845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OCA4_RS03850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OCA4_RS03860	COG1028	Short-chain dehydrogenase reductase Sdr
OCA4_RS03860	COG0604	alcohol dehydrogenase
OCA4_RS03860	COG3321	synthase
OCA4_RS03930	COG2358	TRAP transporter, solute receptor (TAXI family
OCA4_RS03960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OCA4_RS03960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OCA4_RS03970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OCA4_RS03975	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OCA4_RS03980	COG0328	RNA-DNA hybrid ribonuclease activity
OCA4_RS03995	COG1678	Uncharacterized ACR, COG1678
OCA4_RS04000	COG5001	Diguanylate cyclase
OCA4_RS04000	COG3300	MHYT domain
OCA4_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
OCA4_RS04005	COG3321	synthase
OCA4_RS04005	COG0604	alcohol dehydrogenase
OCA4_RS04020	COG0254	rRNA binding
OCA4_RS04025	COG1132	(ABC) transporter
OCA4_RS04045	COG0483	inositol monophosphate 1-phosphatase activity
OCA4_RS04060	COG3588	fructose-bisphosphate aldolase
OCA4_RS04065	COG0126	phosphoglycerate kinase activity
OCA4_RS04090	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
OCA4_RS04095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OCA4_RS04100	COG1692	metallophosphoesterase
OCA4_RS04105	COG0217	transcriptional regulatory protein
OCA4_RS04110	COG2239	Acts as a magnesium transporter
OCA4_RS04115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OCA4_RS04120	COG0632	four-way junction helicase activity
OCA4_RS04130	COG2255	four-way junction helicase activity
OCA4_RS04140	COG0824	Thioesterase
OCA4_RS04165	COG0848	biopolymer transport protein
OCA4_RS04175	COG0823	Involved in the tonB-independent uptake of proteins
OCA4_RS04180	COG2885	chlorophyll binding
OCA4_RS04190	COG0037	tRNA processing
OCA4_RS04195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OCA4_RS04205	COG1309	transcriptional regulator
OCA4_RS04210	COG0277	FAD linked oxidase domain protein
OCA4_RS04215	COG0277	FAD linked oxidase domain protein
OCA4_RS04220	COG0247	lactate metabolic process
OCA4_RS04235	COG4178	(ABC) transporter
OCA4_RS04240	COG1620	l-lactate permease
OCA4_RS04260	COG0459	protein refolding
OCA4_RS04265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OCA4_RS04285	COG1376	ErfK ybiS ycfS ynhG family protein
OCA4_RS04285	COG1388	LysM domain
OCA4_RS04290	COG3416	Protein conserved in bacteria
OCA4_RS04300	COG0463	Glycosyl transferase, family 2
OCA4_RS04305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OCA4_RS04310	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
OCA4_RS04330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OCA4_RS04340	COG0312	modulator of DNA gyrase
OCA4_RS04345	COG1218	3'(2'),5'-bisphosphate nucleotidase
OCA4_RS04360	COG1519	Transferase
OCA4_RS04365	COG1663	tetraacyldisaccharide 4'-kinase activity
OCA4_RS04380	COG1570	exodeoxyribonuclease VII activity
OCA4_RS04385	COG0151	Belongs to the GarS family
OCA4_RS04395	COG0590	tRNA wobble adenosine to inosine editing
OCA4_RS04400	COG1187	pseudouridine synthase activity
OCA4_RS04405	COG0742	ribosomal rna small subunit methyltransferase
OCA4_RS04410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OCA4_RS04420	COG0612	Peptidase, M16
OCA4_RS04425	COG0612	Peptidase, M16
OCA4_RS04435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OCA4_RS04440	COG4771	TonB-dependent receptor
OCA4_RS04445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OCA4_RS04450	COG0196	riboflavin kinase activity
OCA4_RS04455	COG0745	RESPONSE REGULATOR receiver
OCA4_RS04480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OCA4_RS04495	COG2852	Protein conserved in bacteria
OCA4_RS04505	COG1942	4-Oxalocrotonate Tautomerase
OCA4_RS04525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OCA4_RS04530	COG1278	Cold shock
OCA4_RS04535	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
OCA4_RS04540	COG0322	excinuclease ABC activity
OCA4_RS04545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OCA4_RS04555	COG0314	molybdopterin synthase activity
OCA4_RS04560	COG2890	protein-(glutamine-N5) methyltransferase activity
OCA4_RS04565	COG0590	tRNA wobble adenosine to inosine editing
OCA4_RS04570	COG0534	Mate efflux family protein
OCA4_RS04575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OCA4_RS04580	COG1846	Transcriptional regulator
OCA4_RS04585	COG0745	RESPONSE REGULATOR receiver
OCA4_RS04590	COG2205	protein histidine kinase activity
OCA4_RS04605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OCA4_RS04615	COG1496	oxidoreductase activity
OCA4_RS04625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OCA4_RS04640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OCA4_RS04645	COG0193	aminoacyl-tRNA hydrolase activity
OCA4_RS04670	COG0488	(ABC) transporter
OCA4_RS04675	COG0556	nucleotide-excision repair
OCA4_RS04685	COG0625	glutathione transferase activity
OCA4_RS04720	COG0436	Aminotransferase
OCA4_RS04735	COG0659	secondary active sulfate transmembrane transporter activity
OCA4_RS04740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OCA4_RS04750	COG1304	FMN binding
OCA4_RS04760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OCA4_RS04765	COG2223	nitrite transmembrane transporter activity
OCA4_RS04790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OCA4_RS04800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OCA4_RS04810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OCA4_RS04825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OCA4_RS04830	COG0564	pseudouridine synthase activity
OCA4_RS04865	COG2010	Cytochrome c
OCA4_RS04880	COG3278	Belongs to the heme-copper respiratory oxidase family
OCA4_RS04890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OCA4_RS04900	COG4566	intracellular signal transduction
OCA4_RS04905	COG4191	Histidine kinase
OCA4_RS04910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OCA4_RS04920	COG0181	hydroxymethylbilane synthase activity
OCA4_RS04925	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OCA4_RS04940	COG1376	ErfK ybiS ycfS ynhG family protein
OCA4_RS04975	COG2198	Histidine kinase
OCA4_RS04975	COG0643	Histidine kinase
OCA4_RS04975	COG0784	Response regulator, receiver
OCA4_RS04985	COG0643	Histidine kinase
OCA4_RS04985	COG0784	Response regulator, receiver
OCA4_RS04985	COG2198	Histidine kinase
OCA4_RS04990	COG2201	protein-glutamate methylesterase activity
OCA4_RS05015	COG1595	DNA-templated transcription, initiation
OCA4_RS05030	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OCA4_RS05040	COG0840	transmembrane signaling receptor activity
OCA4_RS05070	COG1802	Transcriptional regulator
OCA4_RS05075	COG1028	Short-chain dehydrogenase reductase Sdr
OCA4_RS05080	COG1116	anion transmembrane transporter activity
OCA4_RS05085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OCA4_RS05105	COG2205	protein histidine kinase activity
OCA4_RS05110	COG4191	Histidine kinase
OCA4_RS05110	COG0784	Response regulator, receiver
OCA4_RS05135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OCA4_RS05155	COG0438	transferase activity, transferring glycosyl groups
OCA4_RS05160	COG2814	Major facilitator Superfamily
OCA4_RS05165	COG0679	Auxin Efflux Carrier
OCA4_RS05175	COG2079	MmgE PrpD family protein
OCA4_RS05185	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OCA4_RS05215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OCA4_RS05225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OCA4_RS05240	COG0366	Alpha amylase catalytic
OCA4_RS05245	COG1640	4-alpha-glucanotransferase
OCA4_RS05250	COG0412	Dienelactone hydrolase
OCA4_RS05270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OCA4_RS05285	COG2897	thiosulfate sulfurtransferase activity
OCA4_RS05295	COG1376	ErfK ybiS ycfS ynhG family protein
OCA4_RS05300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OCA4_RS05310	COG4106	trans-aconitate 2-methyltransferase activity
OCA4_RS05355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OCA4_RS05365	COG2204	response regulator
OCA4_RS05375	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
OCA4_RS05385	COG2022	thiamine diphosphate biosynthetic process
OCA4_RS05455	COG0523	cobalamin synthesis protein
OCA4_RS05460	COG4771	TonB-dependent receptor
OCA4_RS05485	COG0714	Associated with various cellular activities
OCA4_RS05495	COG0494	nUDIX hydrolase
OCA4_RS05505	COG0617	tRNA 3'-terminal CCA addition
OCA4_RS05520	COG0408	coproporphyrinogen oxidase activity
OCA4_RS05530	COG0602	queuosine metabolic process
OCA4_RS05535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OCA4_RS05540	COG0723	plastoquinol--plastocyanin reductase activity
OCA4_RS05545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OCA4_RS05545	COG2857	Cytochrome c1
OCA4_RS05560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OCA4_RS05580	COG1704	LemA family
OCA4_RS05595	COG1196	nuclear chromosome segregation
OCA4_RS05610	COG1194	a g-specific adenine glycosylase
OCA4_RS05615	COG0625	glutathione transferase activity
OCA4_RS05625	COG2189	Belongs to the N(4) N(6)-methyltransferase family
OCA4_RS05630	COG2321	neutral zinc metallopeptidase
OCA4_RS05635	COG0521	Mo-molybdopterin cofactor biosynthetic process
OCA4_RS05680	COG2814	Major facilitator Superfamily
OCA4_RS05685	COG1028	Short-chain dehydrogenase reductase Sdr
OCA4_RS05690	COG1573	uracil-dna glycosylase
OCA4_RS05710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OCA4_RS05715	COG0142	geranyltranstransferase activity
OCA4_RS05740	COG0752	glycyl-tRNA synthetase alpha subunit
OCA4_RS05745	COG2852	Protein conserved in bacteria
OCA4_RS05750	COG0751	glycine-tRNA ligase activity
OCA4_RS05760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OCA4_RS05760	COG0574	Belongs to the PEP-utilizing enzyme family
OCA4_RS05775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OCA4_RS05780	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OCA4_RS05785	COG0604	alcohol dehydrogenase
OCA4_RS05810	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
OCA4_RS05815	COG2818	Glycosylase
OCA4_RS05820	COG0354	folic acid binding
OCA4_RS05825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OCA4_RS05850	COG2135	peptidase activity
OCA4_RS05855	COG0277	FAD linked oxidase domain protein
OCA4_RS05860	COG0009	L-threonylcarbamoyladenylate synthase
OCA4_RS05880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OCA4_RS05880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OCA4_RS05885	COG1960	acyl-CoA dehydrogenase activity
OCA4_RS05910	COG1376	ErfK ybiS ycfS ynhG family protein
OCA4_RS05920	COG1324	tolerance protein
OCA4_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
OCA4_RS05935	COG0259	pyridoxamine-phosphate oxidase activity
OCA4_RS05945	COG0484	heat shock protein binding
OCA4_RS05970	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OCA4_RS05975	COG0406	alpha-ribazole phosphatase activity
OCA4_RS05980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OCA4_RS05995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OCA4_RS06000	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
OCA4_RS06005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OCA4_RS06010	COG1722	exodeoxyribonuclease VII activity
OCA4_RS06015	COG0123	including yeast histone deacetylase and acetoin utilization protein
OCA4_RS06020	COG1024	Enoyl-CoA hydratase
OCA4_RS06025	COG1960	acyl-CoA dehydrogenase activity
OCA4_RS06040	COG5001	Diguanylate cyclase
OCA4_RS06045	COG0519	Catalyzes the synthesis of GMP from XMP
OCA4_RS06055	COG1309	transcriptional regulator
OCA4_RS06065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OCA4_RS06070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OCA4_RS06090	COG3181	Tripartite tricarboxylate transporter family receptor
OCA4_RS06110	COG3052	prosthetic group binding
OCA4_RS06130	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
OCA4_RS06220	COG3842	ATPase activity
OCA4_RS06240	COG1120	ATPase activity
OCA4_RS06260	COG2201	protein-glutamate methylesterase activity
OCA4_RS06270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OCA4_RS06280	COG0243	molybdopterin cofactor binding
OCA4_RS06285	COG1648	precorrin-2 dehydrogenase activity
OCA4_RS06285	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OCA4_RS06295	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OCA4_RS06295	COG3218	ABC-type transport auxiliary lipoprotein component
OCA4_RS06300	COG1127	ABC transporter
OCA4_RS06315	COG0071	Belongs to the small heat shock protein (HSP20) family
OCA4_RS06325	COG0517	IMP dehydrogenase activity
OCA4_RS06340	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
OCA4_RS06345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OCA4_RS06345	COG1042	CoA-binding domain protein
OCA4_RS06345	COG0045	succinate-CoA ligase (ADP-forming) activity
OCA4_RS06410	COG0625	glutathione transferase activity
OCA4_RS06420	COG0318	PFAM AMP-dependent synthetase and ligase
OCA4_RS06440	COG1172	Belongs to the binding-protein-dependent transport system permease family
OCA4_RS06460	COG0583	DNA-binding transcription factor activity
OCA4_RS06470	COG0463	Glycosyl transferase, family 2
OCA4_RS06470	COG1216	Glycosyl transferase, family 2
OCA4_RS06475	COG1414	Transcriptional regulator
OCA4_RS06480	COG4948	Mandelate Racemase Muconate Lactonizing
OCA4_RS06520	COG0625	glutathione transferase activity
OCA4_RS06560	COG0318	PFAM AMP-dependent synthetase and ligase
OCA4_RS06570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OCA4_RS06575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OCA4_RS06580	COG3842	ATPase activity
OCA4_RS06585	COG1176	ABC-type spermidine putrescine transport system, permease component I
OCA4_RS06610	COG0437	4 iron, 4 sulfur cluster binding
OCA4_RS06620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OCA4_RS06665	COG3706	GGDEF domain
OCA4_RS06670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OCA4_RS06675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OCA4_RS06675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OCA4_RS06680	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OCA4_RS06685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OCA4_RS06695	COG1414	Transcriptional regulator
OCA4_RS06705	COG0477	Major facilitator Superfamily
OCA4_RS06715	COG1414	Transcriptional regulator
OCA4_RS06720	COG0028	Belongs to the TPP enzyme family
OCA4_RS06725	COG0583	DNA-binding transcription factor activity
OCA4_RS06730	COG3181	Tripartite tricarboxylate transporter family receptor
OCA4_RS06745	COG1012	belongs to the aldehyde dehydrogenase family
OCA4_RS06755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OCA4_RS06770	COG5001	Diguanylate cyclase
OCA4_RS06770	COG3300	MHYT domain
OCA4_RS06775	COG0667	Aldo Keto reductase
OCA4_RS06785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OCA4_RS06790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OCA4_RS06795	COG0156	8-amino-7-oxononanoate synthase activity
OCA4_RS06805	COG4774	siderophore transport
OCA4_RS06810	COG3128	pkhd-type hydroxylase
OCA4_RS06820	COG0848	biopolymer transport protein
OCA4_RS06830	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
OCA4_RS06850	COG0746	molybdenum cofactor guanylyltransferase activity
OCA4_RS06855	COG1763	Mo-molybdopterin cofactor biosynthetic process
OCA4_RS06860	COG0303	'Molybdopterin
OCA4_RS06900	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OCA4_RS06905	COG3383	formate dehydrogenase (NAD+) activity
OCA4_RS06935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OCA4_RS06945	COG0277	FAD linked oxidase domain protein
OCA4_RS06945	COG0247	lactate metabolic process
OCA4_RS06955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OCA4_RS06965	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OCA4_RS06985	COG1309	transcriptional regulator
OCA4_RS06995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OCA4_RS07020	COG0656	L-ascorbic acid biosynthetic process
OCA4_RS07025	COG2900	Belongs to the SlyX family
OCA4_RS07030	COG1054	Belongs to the UPF0176 family
OCA4_RS07035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OCA4_RS07045	COG1562	ergosterol biosynthetic process
OCA4_RS07050	COG1562	ergosterol biosynthetic process
OCA4_RS07055	COG1233	COG1233 Phytoene dehydrogenase and related
OCA4_RS07060	COG1657	PFAM Prenyltransferase squalene oxidase
OCA4_RS07065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OCA4_RS07075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OCA4_RS07080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OCA4_RS07085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OCA4_RS07090	COG2409	Drug exporters of the RND superfamily
OCA4_RS07115	COG1473	amidohydrolase
OCA4_RS07135	COG0427	acetyl-CoA hydrolase
OCA4_RS07185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OCA4_RS07195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OCA4_RS07205	COG0433	COG0433 Predicted ATPase
OCA4_RS07225	COG4957	zinc ion binding
OCA4_RS07240	COG2166	iron-sulfur cluster assembly
OCA4_RS07250	COG2205	protein histidine kinase activity
OCA4_RS07290	COG0861	Integral membrane protein TerC family
OCA4_RS07315	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OCA4_RS07320	COG2983	Belongs to the UPF0260 family
OCA4_RS07325	COG0477	Major facilitator Superfamily
OCA4_RS07355	COG4695	Portal protein
OCA4_RS07515	COG4235	cytochrome complex assembly
OCA4_RS07520	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OCA4_RS07525	COG1138	Cytochrome C-type biogenesis protein
OCA4_RS07530	COG3088	subunit of a heme lyase
OCA4_RS07540	COG0745	RESPONSE REGULATOR receiver
OCA4_RS07545	COG2205	protein histidine kinase activity
OCA4_RS07555	COG0045	succinate-CoA ligase (ADP-forming) activity
OCA4_RS07560	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OCA4_RS07570	COG1414	Transcriptional regulator
OCA4_RS07575	COG3960	tartronate-semialdehyde synthase activity
OCA4_RS07580	COG3622	Belongs to the hyi family
OCA4_RS07585	COG2084	Dehydrogenase
OCA4_RS07590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OCA4_RS07600	COG0179	Fumarylacetoacetate (FAA) hydrolase
OCA4_RS07605	COG1802	Transcriptional regulator
OCA4_RS07610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OCA4_RS07615	COG0045	succinate-CoA ligase (ADP-forming) activity
OCA4_RS07635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OCA4_RS07650	COG2832	Protein of unknown function (DUF454)
OCA4_RS07660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OCA4_RS07675	COG2205	protein histidine kinase activity
OCA4_RS07680	COG1285	pathogenesis
OCA4_RS07685	COG0306	phosphate transporter
OCA4_RS07690	COG1392	Phosphate transport regulator
OCA4_RS07700	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OCA4_RS07705	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OCA4_RS07710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCA4_RS07720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OCA4_RS07730	COG0546	phosphoglycolate phosphatase activity
OCA4_RS07735	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
OCA4_RS07755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OCA4_RS07760	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
OCA4_RS07780	COG0215	cysteine-tRNA ligase activity
OCA4_RS07795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OCA4_RS07810	COG5265	(ABC) transporter
OCA4_RS07815	COG0688	phosphatidylethanolamine metabolic process
OCA4_RS07820	COG1183	phosphatidylcholine synthase activity
OCA4_RS07825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OCA4_RS07835	COG3158	transport of potassium into the cell
OCA4_RS07860	COG0604	alcohol dehydrogenase
OCA4_RS07860	COG3321	synthase
OCA4_RS07865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OCA4_RS07870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OCA4_RS07875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OCA4_RS07880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OCA4_RS07910	COG4774	siderophore transport
OCA4_RS07935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OCA4_RS07940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OCA4_RS07970	COG0583	DNA-binding transcription factor activity
OCA4_RS07975	COG0488	(ABC) transporter
OCA4_RS07980	COG1671	Belongs to the UPF0178 family
OCA4_RS07990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
OCA4_RS08010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OCA4_RS08010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OCA4_RS08015	COG0519	Catalyzes the synthesis of GMP from XMP
OCA4_RS08015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OCA4_RS08045	COG5489	Protein of unknown function (DUF736)
OCA4_RS08095	COG5489	Protein of unknown function (DUF736)
OCA4_RS08115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OCA4_RS08180	COG4962	Type ii secretion system protein e
OCA4_RS08195	COG3451	type IV secretory pathway VirB4
OCA4_RS08225	COG2948	multi-organism process
OCA4_RS08240	COG0464	growth
OCA4_RS08325	COG0038	chloride channel
OCA4_RS08335	COG1393	Belongs to the ArsC family
OCA4_RS08370	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OCA4_RS08380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OCA4_RS08400	COG0300	oxidoreductase activity
OCA4_RS08410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OCA4_RS08415	COG1286	toxin biosynthetic process
OCA4_RS08425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OCA4_RS08430	COG0305	Participates in initiation and elongation during chromosome replication
OCA4_RS08435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OCA4_RS08445	COG0359	binds to the 23S rRNA
OCA4_RS08455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OCA4_RS08460	COG0360	Binds together with S18 to 16S ribosomal RNA
OCA4_RS08465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OCA4_RS08475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OCA4_RS08480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OCA4_RS08485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OCA4_RS08490	COG1561	YicC-like family, N-terminal region
OCA4_RS08495	COG0194	GDP metabolic process
OCA4_RS08500	COG0477	Major facilitator Superfamily
OCA4_RS08520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OCA4_RS08535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OCA4_RS08545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OCA4_RS08560	COG0488	(ABC) transporter
OCA4_RS08575	COG0105	UTP biosynthetic process
OCA4_RS08580	COG0861	Integral membrane protein TerC family
OCA4_RS08585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OCA4_RS08590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OCA4_RS08605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OCA4_RS08610	COG0248	Ppx GppA phosphatase
OCA4_RS08620	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
OCA4_RS08625	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OCA4_RS08630	COG0280	phosphate acetyltransferase
OCA4_RS08630	COG0281	malic enzyme
OCA4_RS08655	COG3045	CreA protein
OCA4_RS08735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OCA4_RS08745	COG0303	'Molybdopterin
OCA4_RS08750	COG0315	cyclic pyranopterin monophosphate synthase activity
OCA4_RS08755	COG0134	indole-3-glycerol-phosphate synthase activity
OCA4_RS08760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OCA4_RS08770	COG0149	triose-phosphate isomerase activity
OCA4_RS08780	COG0504	CTP synthase activity
OCA4_RS08800	COG2877	3-deoxy-8-phosphooctulonate synthase activity
OCA4_RS08815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OCA4_RS08820	COG0148	phosphopyruvate hydratase activity
OCA4_RS08825	COG0431	NADPH-dependent FMN reductase
OCA4_RS08845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OCA4_RS08850	COG0022	dehydrogenase e1 component
OCA4_RS08850	COG0508	dehydrogenase complex catalyzes the overall conversion of
OCA4_RS08855	COG0508	dehydrogenase complex catalyzes the overall conversion of
OCA4_RS08870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OCA4_RS08880	COG0129	dihydroxy-acid dehydratase activity
OCA4_RS08890	COG0708	Exodeoxyribonuclease III
OCA4_RS08895	COG0316	Belongs to the HesB IscA family
OCA4_RS08900	COG0232	Belongs to the dGTPase family. Type 2 subfamily
OCA4_RS08905	COG0018	arginyl-trna synthetase
OCA4_RS08915	COG1472	Belongs to the glycosyl hydrolase 3 family
OCA4_RS08920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OCA4_RS08925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OCA4_RS08935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OCA4_RS08940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OCA4_RS08945	COG0805	protein transport
OCA4_RS08950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OCA4_RS08955	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OCA4_RS08965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OCA4_RS08990	COG1862	Preprotein translocase
OCA4_RS08995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OCA4_RS09015	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
OCA4_RS09020	COG0693	protein deglycase activity
OCA4_RS09070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OCA4_RS09080	COG0629	single-stranded DNA binding
OCA4_RS09085	COG2095	MarC family integral membrane protein
OCA4_RS09090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OCA4_RS09100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OCA4_RS09115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OCA4_RS09120	COG0343	queuine tRNA-ribosyltransferase activity
OCA4_RS09130	COG0840	transmembrane signaling receptor activity
OCA4_RS09170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OCA4_RS09175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OCA4_RS09200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OCA4_RS09230	COG4774	siderophore transport
OCA4_RS09235	COG3785	DNA binding
OCA4_RS09240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OCA4_RS09245	COG1183	phosphatidylcholine synthase activity
OCA4_RS09250	COG1253	flavin adenine dinucleotide binding
OCA4_RS09260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OCA4_RS09265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OCA4_RS09270	COG1984	allophanate hydrolase subunit 2
OCA4_RS09275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OCA4_RS09280	COG0473	3-isopropylmalate dehydrogenase activity
OCA4_RS09280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OCA4_RS09310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
OCA4_RS09315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OCA4_RS09330	COG1177	transmembrane transport
OCA4_RS09335	COG3842	ATPase activity
OCA4_RS09340	COG2132	Multicopper oxidase
OCA4_RS09360	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
OCA4_RS09370	COG0582	viral genome integration into host DNA
OCA4_RS09590	COG1686	Belongs to the peptidase S11 family
OCA4_RS09595	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OCA4_RS09600	COG0470	DNA polymerase III
OCA4_RS09610	COG0084	hydrolase, TatD family'
OCA4_RS09615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OCA4_RS09615	COG0321	lipoyl(octanoyl) transferase activity
OCA4_RS09620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OCA4_RS09655	COG3206	protein involved in exopolysaccharide biosynthesis
OCA4_RS09655	COG0489	protein tyrosine kinase activity
OCA4_RS09695	COG0438	transferase activity, transferring glycosyl groups
OCA4_RS09705	COG2226	methyltransferase
OCA4_RS09710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OCA4_RS09715	COG3956	TIGRFAM MazG family protein
OCA4_RS09720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OCA4_RS09725	COG1923	regulation of RNA biosynthetic process
OCA4_RS09730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OCA4_RS09735	COG2204	response regulator
OCA4_RS09740	COG5000	phosphorelay sensor kinase activity
OCA4_RS09760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OCA4_RS09760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
OCA4_RS09770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OCA4_RS09775	COG2094	Belongs to the DNA glycosylase MPG family
OCA4_RS09780	COG0525	valine-tRNA ligase activity
OCA4_RS09795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OCA4_RS09825	COG4172	Belongs to the ABC transporter superfamily
OCA4_RS09830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OCA4_RS09845	COG0129	dihydroxy-acid dehydratase activity
OCA4_RS09855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OCA4_RS09860	COG0583	DNA-binding transcription factor activity
OCA4_RS09865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OCA4_RS09870	COG1960	acyl-CoA dehydrogenase activity
OCA4_RS09875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OCA4_RS09880	COG1024	Enoyl-CoA hydratase
OCA4_RS09905	COG1538	Outer membrane efflux protein
OCA4_RS09915	COG1126	abc transporter atp-binding protein
OCA4_RS09920	COG0765	amino acid transport
OCA4_RS09925	COG4597	amino acid ABC transporter
OCA4_RS09930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OCA4_RS09935	COG0626	cystathionine gamma-synthase activity
OCA4_RS09945	COG0463	Glycosyl transferase, family 2
OCA4_RS09950	COG0671	phosphoesterase, PA-phosphatase related
OCA4_RS09955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OCA4_RS10045	COG1278	Cold shock
OCA4_RS10085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OCA4_RS10095	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
OCA4_RS10100	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
OCA4_RS10115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OCA4_RS10120	COG1494	fructose-1,6-bisphosphatase
OCA4_RS10130	COG0436	Aminotransferase
OCA4_RS10140	COG3243	poly(R)-hydroxyalkanoic acid synthase
OCA4_RS10150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OCA4_RS10155	COG0586	Pfam SNARE associated Golgi protein
OCA4_RS10160	COG0187	DNA topoisomerase II activity
OCA4_RS10170	COG0513	Belongs to the DEAD box helicase family
OCA4_RS10175	COG3706	GGDEF domain
OCA4_RS10180	COG0316	Belongs to the HesB IscA family
OCA4_RS10185	COG2151	metal-sulfur cluster biosynthetic enzyme
OCA4_RS10190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OCA4_RS10195	COG0719	Fe-S assembly protein
OCA4_RS10200	COG0396	ATPase activity
OCA4_RS10205	COG0719	Fe-S assembly protein
OCA4_RS10210	COG1104	cysteine desulfurase activity
OCA4_RS10215	COG2945	thiolester hydrolase activity
OCA4_RS10220	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
OCA4_RS10225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OCA4_RS10235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OCA4_RS10240	COG0739	heme binding
OCA4_RS10250	COG0590	tRNA wobble adenosine to inosine editing
OCA4_RS10260	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OCA4_RS10265	COG0860	N-Acetylmuramoyl-L-alanine amidase
OCA4_RS10270	COG1530	ribonuclease E activity
OCA4_RS10270	COG1530	ribonuclease E activity
OCA4_RS10275	COG0436	Aminotransferase
OCA4_RS10290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OCA4_RS10295	COG0511	ligase activity, forming carbon-carbon bonds
OCA4_RS10305	COG2205	protein histidine kinase activity
OCA4_RS10310	COG0784	Response regulator, receiver
OCA4_RS10315	COG0745	RESPONSE REGULATOR receiver
OCA4_RS10320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OCA4_RS10325	COG2333	competence protein COMEC
OCA4_RS10325	COG0658	competence protein
OCA4_RS10330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OCA4_RS10335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OCA4_RS10340	COG0372	Belongs to the citrate synthase family
OCA4_RS10350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OCA4_RS10355	COG3494	Protein of unknown function (DUF1009)
OCA4_RS10360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OCA4_RS10365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OCA4_RS10370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OCA4_RS10375	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OCA4_RS10380	COG0750	zinc metalloprotease
OCA4_RS10385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OCA4_RS10395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OCA4_RS10400	COG0233	cytoplasmic translational termination
OCA4_RS10405	COG0528	UMP kinase activity
OCA4_RS10410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OCA4_RS10415	COG0052	Belongs to the universal ribosomal protein uS2 family
OCA4_RS10445	COG1136	(ABC) transporter
OCA4_RS10455	COG0442	prolyl-tRNA aminoacylation
OCA4_RS10465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OCA4_RS10475	COG4774	siderophore transport
OCA4_RS10475	COG4774	siderophore transport
OCA4_RS10490	COG0346	lactoylglutathione lyase activity
OCA4_RS10505	COG1007	ATP synthesis coupled electron transport
OCA4_RS10520	COG0713	ATP synthesis coupled electron transport
OCA4_RS10530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OCA4_RS10535	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
OCA4_RS10545	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OCA4_RS10550	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
OCA4_RS10555	COG0649	NAD binding
OCA4_RS10565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OCA4_RS10570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OCA4_RS10580	COG0473	3-isopropylmalate dehydrogenase activity
OCA4_RS10590	COG0776	regulation of translation
OCA4_RS10600	COG2195	Cleaves the N-terminal amino acid of tripeptides
OCA4_RS10610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OCA4_RS10625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OCA4_RS10630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OCA4_RS10635	COG0740	serine-type endopeptidase activity
OCA4_RS10640	COG0544	peptidyl-prolyl cis-trans isomerase activity
OCA4_RS10655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OCA4_RS10655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OCA4_RS10660	COG0347	Belongs to the P(II) protein family
OCA4_RS10665	COG0174	glutamine synthetase
OCA4_RS10690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OCA4_RS10695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OCA4_RS10715	COG0672	)-iron permease
OCA4_RS10720	COG1612	heme a metabolic process
OCA4_RS10760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OCA4_RS10775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OCA4_RS10775	COG2755	lipolytic protein G-D-S-L family
OCA4_RS10785	COG0776	regulation of translation
OCA4_RS10790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OCA4_RS10795	COG0416	fatty acid biosynthetic process
OCA4_RS10830	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
OCA4_RS10835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OCA4_RS10840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OCA4_RS10845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OCA4_RS10855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OCA4_RS10855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OCA4_RS10860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OCA4_RS10865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OCA4_RS10885	COG0113	porphobilinogen synthase activity
OCA4_RS10895	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
OCA4_RS10905	COG1914	H( )-stimulated, divalent metal cation uptake system
OCA4_RS10915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OCA4_RS10925	COG1381	Involved in DNA repair and RecF pathway recombination
OCA4_RS10940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OCA4_RS10945	COG0571	ribonuclease III activity
OCA4_RS10950	COG0681	Belongs to the peptidase S26 family
OCA4_RS10955	COG0736	holo-[acyl-carrier-protein] synthase activity
OCA4_RS10960	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OCA4_RS10970	COG1758	RNA polymerase activity
OCA4_RS10990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OCA4_RS10995	COG1970	mechanosensitive ion channel activity
OCA4_RS11000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OCA4_RS11005	COG0741	lytic transglycosylase activity
OCA4_RS11055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OCA4_RS11095	COG1335	isochorismatase
OCA4_RS11105	COG0583	DNA-binding transcription factor activity
OCA4_RS11115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OCA4_RS11135	COG0154	amidase activity
OCA4_RS11145	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OCA4_RS11150	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OCA4_RS11160	COG1960	acyl-CoA dehydrogenase activity
OCA4_RS11170	COG0540	Belongs to the ATCase OTCase family
OCA4_RS11175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OCA4_RS11180	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OCA4_RS11185	COG0758	DNA mediated transformation
OCA4_RS11195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OCA4_RS11200	COG0557	exoribonuclease II activity
OCA4_RS11220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OCA4_RS11230	COG0784	Response regulator, receiver
OCA4_RS11240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OCA4_RS11280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OCA4_RS11295	COG1686	Belongs to the peptidase S11 family
OCA4_RS11310	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OCA4_RS11360	COG0726	polysaccharide deacetylase
OCA4_RS11375	COG0405	Gamma-glutamyltransferase
OCA4_RS11385	COG2258	MOSC domain
OCA4_RS11400	COG0321	lipoyl(octanoyl) transferase activity
OCA4_RS11415	COG1254	Belongs to the acylphosphatase family
OCA4_RS11425	COG0450	alkyl hydroperoxide reductase
OCA4_RS11430	COG0415	Belongs to the DNA photolyase family
OCA4_RS11435	COG0697	spore germination
OCA4_RS11440	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OCA4_RS11445	COG0596	Alpha beta hydrolase
OCA4_RS11450	COG1764	response to oxidative stress
OCA4_RS11455	COG1846	Transcriptional regulator
OCA4_RS11480	COG0583	DNA-binding transcription factor activity
OCA4_RS11485	COG1073	alpha beta
OCA4_RS11490	COG1073	alpha beta
OCA4_RS11495	COG0702	epimerase
OCA4_RS11510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OCA4_RS11535	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OCA4_RS11555	COG0564	pseudouridine synthase activity
OCA4_RS11560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OCA4_RS11570	COG1733	regulation of RNA biosynthetic process
OCA4_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
OCA4_RS11595	COG0203	ribosomal protein L17
OCA4_RS11600	COG0202	RNA polymerase activity
OCA4_RS11605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OCA4_RS11610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OCA4_RS11615	COG0563	adenylate kinase activity
OCA4_RS11625	COG0200	Binds to the 23S rRNA
OCA4_RS11630	COG1841	ribosomal large subunit assembly
OCA4_RS11635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OCA4_RS11640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OCA4_RS11645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OCA4_RS11650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OCA4_RS11655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OCA4_RS11660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OCA4_RS11665	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OCA4_RS11670	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OCA4_RS11675	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OCA4_RS11685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OCA4_RS11690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OCA4_RS11695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OCA4_RS11700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OCA4_RS11705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OCA4_RS11710	COG0089	rRNA binding
OCA4_RS11715	COG0088	Forms part of the polypeptide exit tunnel
OCA4_RS11720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OCA4_RS11725	COG0051	transcription antitermination factor activity, RNA binding
OCA4_RS11730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OCA4_RS11735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OCA4_RS11740	COG0049	tRNA binding
OCA4_RS11745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OCA4_RS11765	COG1132	(ABC) transporter
OCA4_RS11770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
OCA4_RS11775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OCA4_RS11780	COG0085	RNA polymerase activity
OCA4_RS11785	COG0222	ribosome binding
OCA4_RS11790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OCA4_RS11795	COG0081	regulation of translation
OCA4_RS11800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OCA4_RS11845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OCA4_RS11870	COG1414	Transcriptional regulator
OCA4_RS11890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OCA4_RS11920	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
OCA4_RS11930	COG4771	TonB-dependent receptor
OCA4_RS11940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OCA4_RS11945	COG2201	protein-glutamate methylesterase activity
OCA4_RS11965	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OCA4_RS11970	COG0302	gtp cyclohydrolase
OCA4_RS11985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OCA4_RS11990	COG2080	2 iron, 2 sulfur cluster binding
OCA4_RS11995	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
OCA4_RS12000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OCA4_RS12005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OCA4_RS12020	COG1752	Esterase of the alpha-beta hydrolase superfamily
OCA4_RS12025	COG0517	IMP dehydrogenase activity
OCA4_RS12280	COG0305	Participates in initiation and elongation during chromosome replication
OCA4_RS12375	COG0328	RNA-DNA hybrid ribonuclease activity
OCA4_RS12380	COG0629	single-stranded DNA binding
OCA4_RS12445	COG0859	PFAM glycosyl transferase family 9
OCA4_RS12515	COG1064	alcohol dehydrogenase
OCA4_RS12520	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
OCA4_RS12525	COG1546	Belongs to the CinA family
OCA4_RS12525	COG1058	Belongs to the CinA family
OCA4_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
OCA4_RS12545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OCA4_RS12550	COG0459	protein refolding
OCA4_RS12580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OCA4_RS12585	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OCA4_RS12600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OCA4_RS12630	COG2068	MobA-Related Protein
OCA4_RS12635	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
OCA4_RS12635	COG3608	succinylglutamate desuccinylase aspartoacylase
OCA4_RS12645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OCA4_RS12690	COG0785	Cytochrome C biogenesis protein
OCA4_RS12695	COG3191	aminopeptidase activity
OCA4_RS12750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OCA4_RS12765	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OCA4_RS12770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OCA4_RS12775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OCA4_RS12780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OCA4_RS12785	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
OCA4_RS12800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OCA4_RS12805	COG0047	phosphoribosylformylglycinamidine synthase activity
OCA4_RS12810	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OCA4_RS12815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OCA4_RS12850	COG0538	isocitrate dehydrogenase activity
OCA4_RS12860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OCA4_RS12860	COG4651	solute:proton antiporter activity
OCA4_RS12870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OCA4_RS12875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OCA4_RS12880	COG0509	glycine decarboxylation via glycine cleavage system
OCA4_RS12885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OCA4_RS12885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OCA4_RS12890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OCA4_RS12895	COG1742	UPF0060 membrane protein
OCA4_RS12900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OCA4_RS12945	COG2814	Major facilitator Superfamily
OCA4_RS12975	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OCA4_RS12975	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OCA4_RS13015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OCA4_RS13020	COG1684	flagellar biosynthetic protein fliR
OCA4_RS13025	COG1987	bacterial-type flagellum assembly
OCA4_RS13030	COG1677	Flagellar hook-basal body complex protein FliE
OCA4_RS13035	COG1558	bacterial-type flagellum-dependent cell motility
OCA4_RS13050	COG1338	Plays a role in the flagellum-specific transport system
OCA4_RS13080	COG4786	Flagellar basal body rod
OCA4_RS13085	COG4786	Flagellar basal body rod
OCA4_RS13095	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
OCA4_RS13115	COG1706	bacterial-type flagellum-dependent cell motility
OCA4_RS13155	COG5443	negative regulation of bacterial-type flagellum assembly
OCA4_RS13165	COG1256	bacterial-type flagellum assembly
OCA4_RS13170	COG1749	Flagellar hook protein flgE
OCA4_RS13205	COG3685	Protein conserved in bacteria
OCA4_RS13210	COG0392	lysyltransferase activity
OCA4_RS13220	COG0492	ferredoxin-NADP+ reductase activity
OCA4_RS13225	COG0633	Ferredoxin
OCA4_RS13240	COG0837	glucose binding
OCA4_RS13245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OCA4_RS13245	COG3218	ABC-type transport auxiliary lipoprotein component
OCA4_RS13250	COG1127	ABC transporter
OCA4_RS13255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OCA4_RS13260	COG4948	Mandelate Racemase Muconate Lactonizing
OCA4_RS13275	COG0438	transferase activity, transferring glycosyl groups
OCA4_RS13300	COG0728	peptidoglycan biosynthetic process
OCA4_RS13310	COG0673	inositol 2-dehydrogenase activity
OCA4_RS13330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
OCA4_RS13330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OCA4_RS13345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OCA4_RS13350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OCA4_RS13355	COG0859	PFAM glycosyl transferase family 9
OCA4_RS13365	COG1132	(ABC) transporter
OCA4_RS13370	COG0179	Fumarylacetoacetate (FAA) hydrolase
OCA4_RS13390	COG1278	Cold shock
OCA4_RS13395	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OCA4_RS13400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OCA4_RS13430	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OCA4_RS13465	COG0318	PFAM AMP-dependent synthetase and ligase
OCA4_RS13485	COG0277	FAD linked oxidase domain protein
OCA4_RS13490	COG2186	Transcriptional regulator
OCA4_RS13515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OCA4_RS13520	COG2326	polyphosphate kinase activity
OCA4_RS13525	COG1881	PFAM PEBP family protein
OCA4_RS13530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OCA4_RS13535	COG0440	acetolactate synthase activity
OCA4_RS13540	COG0028	Belongs to the TPP enzyme family
OCA4_RS13555	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OCA4_RS13570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OCA4_RS13575	COG0560	Phosphoserine phosphatase
OCA4_RS13575	COG3830	Belongs to the UPF0237 family
OCA4_RS13590	COG0330	HflC and HflK could
OCA4_RS13595	COG0330	HflC and HflK could
OCA4_RS13605	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OCA4_RS13615	COG0114	fumarate hydratase activity
OCA4_RS13635	COG0277	FAD linked oxidase domain protein
OCA4_RS13645	COG0210	DNA helicase
OCA4_RS13650	COG1131	(ABC) transporter
OCA4_RS13655	COG0842	Transport permease protein
OCA4_RS13680	COG2264	protein methyltransferase activity
OCA4_RS13690	COG0006	proline dipeptidase activity
OCA4_RS13695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OCA4_RS13705	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OCA4_RS13715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OCA4_RS13720	COG0849	cell division
OCA4_RS13725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OCA4_RS13730	COG1181	Belongs to the D-alanine--D-alanine ligase family
OCA4_RS13740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OCA4_RS13745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OCA4_RS13750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OCA4_RS13760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OCA4_RS13770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OCA4_RS13780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OCA4_RS13795	COG0275	rRNA processing
OCA4_RS13815	COG1309	transcriptional regulator
OCA4_RS13840	COG1250	3-hydroxyacyl-CoA dehydrogenase
OCA4_RS13840	COG1024	Enoyl-CoA hydratase
OCA4_RS13855	COG3237	CsbD-like
OCA4_RS13860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OCA4_RS13870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OCA4_RS13870	COG0512	Glutamine amidotransferase of anthranilate synthase
OCA4_RS13875	COG2204	response regulator
OCA4_RS13880	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OCA4_RS13890	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OCA4_RS13895	COG1766	The M ring may be actively involved in energy transduction
OCA4_RS13915	COG0482	sulfurtransferase activity
OCA4_RS13930	COG1611	Belongs to the LOG family
OCA4_RS13950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OCA4_RS13950	COG2111	Na H antiporter
OCA4_RS13955	COG1006	Multisubunit Na H antiporter MnhC subunit
OCA4_RS13960	COG0651	ATP synthesis coupled electron transport
OCA4_RS13970	COG2212	antiporter activity
OCA4_RS13975	COG1320	monovalent cation:proton antiporter activity
OCA4_RS13985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OCA4_RS13990	COG2391	methyltransferase activity
OCA4_RS14010	COG0737	Belongs to the 5'-nucleotidase family
OCA4_RS14040	COG3258	Cytochrome c
OCA4_RS14045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OCA4_RS14050	COG0640	Transcriptional regulator
OCA4_RS14065	COG0587	DNA-directed DNA polymerase activity
OCA4_RS14080	COG1573	uracil-dna glycosylase
OCA4_RS14085	COG1793	dna ligase
OCA4_RS14095	COG1201	RNA secondary structure unwinding
OCA4_RS14130	COG1921	L-seryl-tRNASec selenium transferase activity
OCA4_RS14140	COG2864	formate dehydrogenase
OCA4_RS14145	COG0437	4 iron, 4 sulfur cluster binding
OCA4_RS14160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OCA4_RS14165	COG1305	Transglutaminase-like
OCA4_RS14175	COG1959	2 iron, 2 sulfur cluster binding
OCA4_RS14185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OCA4_RS14195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OCA4_RS14200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OCA4_RS14215	COG2951	lytic endotransglycosylase activity
OCA4_RS14230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OCA4_RS14235	COG0358	DNA primase activity
OCA4_RS14245	COG0640	Transcriptional regulator
OCA4_RS14260	COG0505	Belongs to the CarA family
OCA4_RS14280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OCA4_RS14285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OCA4_RS14295	COG2259	Doxx family
OCA4_RS14305	COG1522	sequence-specific DNA binding
OCA4_RS14310	COG0492	ferredoxin-NADP+ reductase activity
OCA4_RS14315	COG0583	DNA-binding transcription factor activity
OCA4_RS14335	COG2205	protein histidine kinase activity
OCA4_RS14340	COG1840	ABC-type Fe3 transport system, periplasmic component
OCA4_RS14365	COG1177	transmembrane transport
OCA4_RS14390	COG3842	ATPase activity
OCA4_RS14395	COG5001	Diguanylate cyclase
OCA4_RS14395	COG3300	MHYT domain
OCA4_RS14425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OCA4_RS14430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OCA4_RS14435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OCA4_RS14440	COG1012	belongs to the aldehyde dehydrogenase family
OCA4_RS14490	COG1164	Oligoendopeptidase f
OCA4_RS14495	COG2204	response regulator
OCA4_RS14500	COG2989	Protein conserved in bacteria
OCA4_RS14510	COG3750	Belongs to the UPF0335 family
OCA4_RS14525	COG0469	pyruvate kinase activity
OCA4_RS14535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OCA4_RS14540	COG0583	DNA-binding transcription factor activity
OCA4_RS14545	COG1741	Belongs to the pirin family
OCA4_RS14550	COG0655	NAD(P)H dehydrogenase (quinone) activity
OCA4_RS14575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OCA4_RS14580	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
OCA4_RS14585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OCA4_RS14590	COG0363	glucosamine-6-phosphate deaminase activity
OCA4_RS14595	COG3265	gluconokinase activity
OCA4_RS14600	COG0561	phosphatase activity
OCA4_RS14605	COG3387	PFAM Glycoside hydrolase 15-related
OCA4_RS14610	COG1272	protein, Hemolysin III
OCA4_RS14615	COG3106	COG3106 Predicted ATPase
OCA4_RS14620	COG3768	UPF0283 membrane protein
OCA4_RS14625	COG1278	Cold shock
OCA4_RS14640	COG3023	N-Acetylmuramoyl-L-alanine amidase
OCA4_RS14650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OCA4_RS14655	COG1120	ATPase activity
OCA4_RS14660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OCA4_RS14665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OCA4_RS14670	COG0521	Mo-molybdopterin cofactor biosynthetic process
OCA4_RS14680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OCA4_RS14685	COG2181	nitrate reductase activity
OCA4_RS14710	COG1024	Enoyl-CoA hydratase
OCA4_RS14715	COG1414	Transcriptional regulator
OCA4_RS14720	COG1012	belongs to the aldehyde dehydrogenase family
OCA4_RS14885	COG0483	inositol monophosphate 1-phosphatase activity
OCA4_RS14890	COG0583	DNA-binding transcription factor activity
OCA4_RS14905	COG0071	Belongs to the small heat shock protein (HSP20) family
OCA4_RS14910	COG1595	DNA-templated transcription, initiation
OCA4_RS14925	COG0067	glutamate synthase
OCA4_RS14925	COG0069	glutamate synthase activity
OCA4_RS14925	COG0070	glutamate synthase
OCA4_RS14945	COG2951	lytic endotransglycosylase activity
OCA4_RS14950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OCA4_RS14970	COG5001	Diguanylate cyclase
OCA4_RS14970	COG4251	negative regulation of phosphorylation
OCA4_RS14970	COG2203	Gaf domain
OCA4_RS14970	COG3706	GGDEF domain
OCA4_RS14995	COG0330	HflC and HflK could
OCA4_RS15000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OCA4_RS15005	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
OCA4_RS15040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OCA4_RS15070	COG0523	cobalamin synthesis protein
OCA4_RS15095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OCA4_RS15100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OCA4_RS15160	COG4558	Periplasmic binding protein
OCA4_RS15165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OCA4_RS15170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
OCA4_RS15180	COG2217	Heavy metal translocating P-type atpase
OCA4_RS15185	COG2217	Heavy metal translocating P-type atpase
OCA4_RS15200	COG1477	protein flavinylation
OCA4_RS15215	COG3038	cytochrome b561
OCA4_RS15260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OCA4_RS15265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OCA4_RS15275	COG1028	Short-chain dehydrogenase reductase Sdr
OCA4_RS15290	COG1309	transcriptional regulator
OCA4_RS15300	COG1131	(ABC) transporter
OCA4_RS15305	COG0842	Transport permease protein
OCA4_RS15310	COG0842	Transport permease protein
OCA4_RS15320	COG0577	efflux transmembrane transporter activity
OCA4_RS15320	COG1136	(ABC) transporter
OCA4_RS15330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OCA4_RS15335	COG1309	transcriptional regulator
OCA4_RS15490	COG1475	DNA binding
OCA4_RS15680	COG0739	heme binding
OCA4_RS15685	COG0542	response to heat
OCA4_RS15700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OCA4_RS15700	COG2813	Specifically methylates the guanine in position
OCA4_RS15705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OCA4_RS15715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OCA4_RS15720	COG0287	Prephenate dehydrogenase
OCA4_RS15750	COG2884	Cell division ATP-binding protein ftsE
OCA4_RS15770	COG0019	diaminopimelate decarboxylase activity
OCA4_RS15780	COG0165	Argininosuccinate lyase
OCA4_RS15785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OCA4_RS15790	COG5507	3-demethylubiquinone-9 3-methyltransferase
OCA4_RS15795	COG2764	glyoxalase bleomycin resistance protein dioxygenase
OCA4_RS15805	COG1250	3-hydroxyacyl-CoA dehydrogenase
OCA4_RS15810	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OCA4_RS15815	COG2086	electron transfer activity
OCA4_RS15820	COG2096	Adenosyltransferase
OCA4_RS15840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OCA4_RS15855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OCA4_RS15885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OCA4_RS15900	COG5001	Diguanylate cyclase
OCA4_RS15910	COG0424	maF-like protein
OCA4_RS15915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OCA4_RS15920	COG5328	Belongs to the UPF0262 family
OCA4_RS15925	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OCA4_RS15935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OCA4_RS15975	COG4774	siderophore transport
OCA4_RS15985	COG1309	transcriptional regulator
OCA4_RS15995	COG0697	spore germination
OCA4_RS16000	COG1764	response to oxidative stress
OCA4_RS16035	COG0235	Class ii aldolase
OCA4_RS16050	COG0156	8-amino-7-oxononanoate synthase activity
OCA4_RS16055	COG4566	intracellular signal transduction
OCA4_RS16060	COG0784	Response regulator, receiver
OCA4_RS16060	COG2205	protein histidine kinase activity
OCA4_RS16080	COG0356	it plays a direct role in the translocation of protons across the membrane
OCA4_RS16090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OCA4_RS16095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OCA4_RS16110	COG0612	Peptidase, M16
OCA4_RS16120	COG3346	SURF1 family
OCA4_RS16130	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
OCA4_RS16140	COG0109	protoheme IX farnesyltransferase activity
OCA4_RS16145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OCA4_RS16150	COG1565	acr, cog1565
OCA4_RS16150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OCA4_RS16160	COG0312	modulator of DNA gyrase
OCA4_RS16180	COG1846	Transcriptional regulator
OCA4_RS16200	COG0534	Mate efflux family protein
OCA4_RS16205	COG0167	dihydroorotate dehydrogenase activity
OCA4_RS16230	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
OCA4_RS16235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OCA4_RS16245	COG1999	signal sequence binding
OCA4_RS16260	COG0717	Belongs to the dCTP deaminase family
OCA4_RS16285	COG2967	ApaG domain
OCA4_RS16295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OCA4_RS16300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OCA4_RS16310	COG0745	RESPONSE REGULATOR receiver
OCA4_RS16315	COG0704	Plays a role in the regulation of phosphate uptake
OCA4_RS16320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OCA4_RS16325	COG0581	inorganic phosphate transmembrane transporter activity
OCA4_RS16330	COG0573	inorganic phosphate transmembrane transporter activity
OCA4_RS16335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
OCA4_RS16340	COG5002	protein histidine kinase activity
OCA4_RS16365	COG1271	oxidase subunit
OCA4_RS16370	COG1294	oxidase, subunit
OCA4_RS16375	COG1376	ErfK ybiS ycfS ynhG family protein
OCA4_RS16380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OCA4_RS16385	COG2514	catechol 2,3-dioxygenase activity
OCA4_RS16400	COG4948	Mandelate Racemase Muconate Lactonizing
OCA4_RS16420	COG0402	S-adenosylhomocysteine deaminase activity
OCA4_RS16425	COG0405	Gamma-glutamyltransferase
OCA4_RS16430	COG2197	response regulator
OCA4_RS16435	COG4585	Histidine kinase
OCA4_RS16460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OCA4_RS16475	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
OCA4_RS16480	COG1877	trehalose-phosphatase activity
OCA4_RS16485	COG0477	Major facilitator Superfamily
OCA4_RS16495	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OCA4_RS16500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OCA4_RS16505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OCA4_RS16510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OCA4_RS16515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OCA4_RS16520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OCA4_RS16525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OCA4_RS16530	COG0799	negative regulation of ribosome biogenesis
OCA4_RS16535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OCA4_RS16545	COG0793	Belongs to the peptidase S41A family
OCA4_RS16560	COG0494	nUDIX hydrolase
OCA4_RS16565	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OCA4_RS16570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OCA4_RS16575	COG1764	response to oxidative stress
OCA4_RS16580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OCA4_RS16585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OCA4_RS16590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OCA4_RS16595	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OCA4_RS16605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OCA4_RS16615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OCA4_RS16620	COG1028	Short-chain dehydrogenase reductase Sdr
OCA4_RS16625	COG0508	dehydrogenase complex catalyzes the overall conversion of
OCA4_RS16635	COG0039	L-malate dehydrogenase activity
OCA4_RS16640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OCA4_RS16645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
OCA4_RS16655	COG4181	ATPase activity
OCA4_RS16665	COG0670	Belongs to the BI1 family
OCA4_RS16685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OCA4_RS16690	COG4133	protoheme IX ABC transporter activity
OCA4_RS16695	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OCA4_RS16700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OCA4_RS16710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OCA4_RS16720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OCA4_RS16735	COG1120	ATPase activity
OCA4_RS16750	COG1215	transferase activity, transferring glycosyl groups
OCA4_RS16760	COG1132	(ABC) transporter
OCA4_RS16775	COG1091	dTDP-4-dehydrorhamnose reductase activity
OCA4_RS16795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OCA4_RS16800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OCA4_RS16805	COG0784	Response regulator, receiver
OCA4_RS16805	COG4191	Histidine kinase
OCA4_RS16820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OCA4_RS16830	COG0268	Binds directly to 16S ribosomal RNA
OCA4_RS16840	COG1192	Involved in chromosome partitioning
OCA4_RS16845	COG1475	DNA binding
OCA4_RS16865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OCA4_RS16880	COG0546	phosphoglycolate phosphatase activity
OCA4_RS16915	COG2197	response regulator
OCA4_RS16945	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
OCA4_RS16950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OCA4_RS16965	COG0587	DNA-directed DNA polymerase activity
OCA4_RS17010	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
OCA4_RS17010	COG3608	succinylglutamate desuccinylase aspartoacylase
OCA4_RS17020	COG3300	MHYT domain
OCA4_RS17020	COG5001	Diguanylate cyclase
OCA4_RS17030	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
OCA4_RS17065	COG0126	phosphoglycerate kinase activity
OCA4_RS17080	COG4451	ribulose bisphosphate carboxylase, small
OCA4_RS17095	COG0546	phosphoglycolate phosphatase activity
OCA4_RS17105	COG2204	response regulator
OCA4_RS17110	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OCA4_RS17115	COG0375	protein maturation
OCA4_RS17140	COG0298	carbon dioxide binding
OCA4_RS17215	COG0864	Transcriptional regulator
OCA4_RS17300	COG3547	Transposase (IS116 IS110 IS902 family)
OCA4_RS17335	COG0305	Participates in initiation and elongation during chromosome replication
OCA4_RS17345	COG5489	Protein of unknown function (DUF736)
OCA4_RS17355	COG3505	Type IV secretory pathway VirD4
OCA4_RS17370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OCA4_RS17430	COG3701	Conjugal transfer protein
OCA4_RS17435	COG3846	protein secretion by the type IV secretion system
OCA4_RS17445	COG5314	conjugation
OCA4_RS17450	COG3451	type IV secretory pathway VirB4
OCA4_RS17455	COG5268	conjugation
OCA4_RS17460	COG3838	Conjugal transfer protein Trbc
OCA4_RS17465	COG4962	Type ii secretion system protein e
OCA4_RS17475	COG1192	Involved in chromosome partitioning
OCA4_RS17480	COG1475	DNA binding
OCA4_RS17485	COG1414	Transcriptional regulator
OCA4_RS17490	COG0629	single-stranded DNA binding
OCA4_RS17505	COG1414	Transcriptional regulator
OCA4_RS17510	COG1192	Involved in chromosome partitioning
OCA4_RS17535	COG1937	Protein conserved in bacteria
OCA4_RS17580	COG0456	acetyltransferase
OCA4_RS17580	COG1214	PFAM Peptidase M22, glycoprotease
OCA4_RS17595	COG2372	response to copper ion
OCA4_RS17635	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OCA4_RS17655	COG1595	DNA-templated transcription, initiation
OCA4_RS17715	COG2217	Heavy metal translocating P-type atpase
OCA4_RS17740	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
OCA4_RS17765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OCA4_RS17770	COG0431	NADPH-dependent FMN reductase
OCA4_RS17780	COG0798	PFAM Bile acid sodium symporter
OCA4_RS17795	COG0640	Transcriptional regulator
OCA4_RS17840	COG2217	Heavy metal translocating P-type atpase
OCA4_RS17910	COG0672	)-iron permease
OCA4_RS17915	COG4786	Flagellar basal body rod
OCA4_RS17920	COG1285	pathogenesis
OCA4_RS17990	COG0697	spore germination
OCA4_RS18000	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
OCA4_RS18010	COG3504	Conjugal transfer protein
OCA4_RS18020	COG3704	protein secretion by the type IV secretion system
OCA4_RS18045	COG3451	type IV secretory pathway VirB4
OCA4_RS18210	COG5489	Protein of unknown function (DUF736)
OCA4_RS18270	COG0464	growth
OCA4_RS18495	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OCA4_RS18650	COG5487	UPF0391 membrane protein
OCA4_RS18725	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OCA4_RS18745	COG3916	Acyl-homoserine-lactone synthase
OCA4_RS18750	COG2197	response regulator
OCA4_RS18780	COG3831	ATPase activity
OCA4_RS18800	COG2197	response regulator