locus-tag	class	description
K5609_RS00020	COG0187	DNA topoisomerase II activity
K5609_RS00030	COG3977	Valine--pyruvate aminotransferase
K5609_RS00035	COG0366	Alpha amylase catalytic
K5609_RS00045	COG0751	glycine-tRNA ligase activity
K5609_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
K5609_RS00055	COG0425	Belongs to the sulfur carrier protein TusA family
K5609_RS00060	COG3842	ATPase activity
K5609_RS00070	COG1175	transmembrane transport
K5609_RS00075	COG1653	transport
K5609_RS00090	COG0183	Belongs to the thiolase family
K5609_RS00095	COG1024	Enoyl-CoA hydratase
K5609_RS00095	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5609_RS00100	COG0006	proline dipeptidase activity
K5609_RS00105	COG1739	Uncharacterized protein family UPF0029
K5609_RS00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5609_RS00115	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
K5609_RS00150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5609_RS00180	COG3695	enzyme binding
K5609_RS00215	COG0583	DNA-binding transcription factor activity
K5609_RS00230	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K5609_RS00255	COG0673	inositol 2-dehydrogenase activity
K5609_RS00275	COG3706	GGDEF domain
K5609_RS00295	COG2205	protein histidine kinase activity
K5609_RS00305	COG2204	response regulator
K5609_RS00310	COG1301	dicarboxylic acid transport
K5609_RS00330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5609_RS00350	COG2828	Protein conserved in bacteria
K5609_RS00355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K5609_RS00360	COG0372	Belongs to the citrate synthase family
K5609_RS00365	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K5609_RS00370	COG1802	Transcriptional regulator
K5609_RS00385	COG2226	methyltransferase
K5609_RS00395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K5609_RS00400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5609_RS00405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5609_RS00410	COG0805	protein transport
K5609_RS00415	COG0084	hydrolase, TatD family'
K5609_RS00430	COG1785	Belongs to the alkaline phosphatase family
K5609_RS00460	COG1764	response to oxidative stress
K5609_RS00465	COG1846	Transcriptional regulator
K5609_RS00475	COG2873	o-acetylhomoserine
K5609_RS00485	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K5609_RS00500	COG0745	RESPONSE REGULATOR receiver
K5609_RS00505	COG2205	protein histidine kinase activity
K5609_RS00520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5609_RS00530	COG0840	transmembrane signaling receptor activity
K5609_RS00535	COG3152	Membrane
K5609_RS00540	COG1451	nucleotide metabolic process
K5609_RS00555	COG0531	amino acid
K5609_RS00565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K5609_RS00575	COG2116	formate transmembrane transporter activity
K5609_RS00580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K5609_RS00580	COG1648	precorrin-2 dehydrogenase activity
K5609_RS00600	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K5609_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
K5609_RS00610	COG0302	gtp cyclohydrolase
K5609_RS00615	COG0513	Belongs to the DEAD box helicase family
K5609_RS00635	COG1671	Belongs to the UPF0178 family
K5609_RS00655	COG1846	Transcriptional regulator
K5609_RS00670	COG3448	diguanylate cyclase activity
K5609_RS00670	COG4175	Glycine betaine
K5609_RS00705	COG1794	racemase activity, acting on amino acids and derivatives
K5609_RS00710	COG1278	Cold shock
K5609_RS00745	COG0513	Belongs to the DEAD box helicase family
K5609_RS00760	COG2815	serine threonine protein kinase
K5609_RS00760	COG0515	serine threonine protein kinase
K5609_RS00795	COG0631	protein serine/threonine phosphatase activity
K5609_RS00895	COG2081	HI0933 family
K5609_RS00905	COG0561	phosphatase activity
K5609_RS00910	COG2267	carboxylic ester hydrolase activity
K5609_RS00940	COG3784	Protein of unknown function (DUF1318)
K5609_RS00970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5609_RS00975	COG0569	domain protein
K5609_RS00980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5609_RS00980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5609_RS01000	COG0758	DNA mediated transformation
K5609_RS01005	COG2922	Belongs to the Smg family
K5609_RS01010	COG0551	DNA topoisomerase type I activity
K5609_RS01015	COG2204	response regulator
K5609_RS01020	COG3852	Histidine kinase
K5609_RS01030	COG0174	glutamine synthetase
K5609_RS01035	COG1217	gtp-binding protein TYPA
K5609_RS01060	COG0659	secondary active sulfate transmembrane transporter activity
K5609_RS01075	COG1609	Transcriptional regulator
K5609_RS01080	COG2723	6-phospho-beta-galactosidase activity
K5609_RS01085	COG3842	ATPase activity
K5609_RS01090	COG3459	Glycosyltransferase 36 associated
K5609_RS01100	COG4580	involved in the transport of maltose and maltodextrins
K5609_RS01120	COG0456	acetyltransferase
K5609_RS01125	COG0583	DNA-binding transcription factor activity
K5609_RS01135	COG2076	Multidrug Resistance protein
K5609_RS01140	COG2076	Multidrug Resistance protein
K5609_RS01145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K5609_RS01150	COG0726	polysaccharide deacetylase
K5609_RS01155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5609_RS01155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5609_RS01160	COG0463	Glycosyl transferase, family 2
K5609_RS01165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5609_RS01175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5609_RS01180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5609_RS01185	COG1349	DNA-binding transcription factor activity
K5609_RS01190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5609_RS01200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5609_RS01210	COG3122	Protein conserved in bacteria
K5609_RS01215	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K5609_RS01220	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K5609_RS01235	COG0071	Belongs to the small heat shock protein (HSP20) family
K5609_RS01245	COG0477	Major facilitator Superfamily
K5609_RS01315	COG1012	belongs to the aldehyde dehydrogenase family
K5609_RS01340	COG0010	Belongs to the arginase family
K5609_RS01360	COG1177	transmembrane transport
K5609_RS01365	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5609_RS01370	COG3842	ATPase activity
K5609_RS01375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5609_RS01385	COG0174	glutamine synthetase
K5609_RS01390	COG0174	glutamine synthetase
K5609_RS01395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5609_RS01400	COG4989	oxidoreductase activity
K5609_RS01420	COG0069	glutamate synthase activity
K5609_RS01455	COG2017	converts alpha-aldose to the beta-anomer
K5609_RS01465	COG0402	S-adenosylhomocysteine deaminase activity
K5609_RS01475	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K5609_RS01490	COG3738	Protein conserved in bacteria
K5609_RS01510	COG0390	transport system, permease component
K5609_RS01520	COG3132	Protein of unknown function, DUF480
K5609_RS01525	COG1566	PFAM secretion protein HlyD family protein
K5609_RS01545	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K5609_RS01550	COG0540	Belongs to the ATCase OTCase family
K5609_RS01560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5609_RS01570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5609_RS01580	COG3206	protein involved in exopolysaccharide biosynthesis
K5609_RS01580	COG0489	protein tyrosine kinase activity
K5609_RS01630	COG4464	protein tyrosine phosphatase activity
K5609_RS01650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K5609_RS01660	COG3031	protein transport across the cell outer membrane
K5609_RS01670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5609_RS01675	COG1459	type II secretion system
K5609_RS01680	COG2165	general secretion pathway protein
K5609_RS01690	COG2165	general secretion pathway protein
K5609_RS01695	COG4795	General secretion pathway protein
K5609_RS01700	COG3156	type II secretion system protein K
K5609_RS01710	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K5609_RS01720	COG1011	Hydrolase
K5609_RS01725	COG0494	nUDIX hydrolase
K5609_RS01730	COG1218	3'(2'),5'-bisphosphate nucleotidase
K5609_RS01740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5609_RS01750	COG2866	Carboxypeptidase
K5609_RS01755	COG0786	glutamate:sodium symporter activity
K5609_RS01760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5609_RS01770	COG0339	signal peptide processing
K5609_RS01775	COG0668	transmembrane transport
K5609_RS01805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5609_RS01810	COG0705	Rhomboid family
K5609_RS01820	COG3161	chorismate lyase activity
K5609_RS01825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K5609_RS01830	COG2937	Belongs to the GPAT DAPAT family
K5609_RS01865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5609_RS01870	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K5609_RS01875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K5609_RS01880	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K5609_RS01905	COG1612	heme a metabolic process
K5609_RS01910	COG0109	protoheme IX farnesyltransferase activity
K5609_RS01915	COG0534	Mate efflux family protein
K5609_RS01920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K5609_RS01925	COG2205	protein histidine kinase activity
K5609_RS01930	COG0745	RESPONSE REGULATOR receiver
K5609_RS01935	COG3678	ATP-independent chaperone mediated protein folding
K5609_RS01955	COG3074	FtsZ-dependent cytokinesis
K5609_RS01960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K5609_RS01965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K5609_RS01970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K5609_RS01995	COG0018	arginyl-trna synthetase
K5609_RS02000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5609_RS02030	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K5609_RS02035	COG0626	cystathionine gamma-synthase activity
K5609_RS02040	COG0527	aspartate kinase activity
K5609_RS02040	COG0460	homoserine dehydrogenase
K5609_RS02045	COG0366	Alpha amylase catalytic
K5609_RS02065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5609_RS02075	COG4206	TonB-dependent receptor
K5609_RS02085	COG0724	RNA recognition motif
K5609_RS02120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5609_RS02125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5609_RS02130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5609_RS02135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5609_RS02140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5609_RS02145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5609_RS02155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5609_RS02160	COG1841	ribosomal large subunit assembly
K5609_RS02165	COG0200	Binds to the 23S rRNA
K5609_RS02170	COG0201	protein transport
K5609_RS02175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5609_RS02185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5609_RS02190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5609_RS02195	COG0202	RNA polymerase activity
K5609_RS02200	COG0203	ribosomal protein L17
K5609_RS02205	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K5609_RS02210	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K5609_RS02220	COG2239	Acts as a magnesium transporter
K5609_RS02230	COG0488	(ABC) transporter
K5609_RS02240	COG1247	-acetyltransferase
K5609_RS02245	COG2900	Belongs to the SlyX family
K5609_RS02255	COG0545	Peptidyl-prolyl cis-trans isomerase
K5609_RS02265	COG2816	NAD+ diphosphatase activity
K5609_RS02270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K5609_RS02280	COG0730	response to heat
K5609_RS02335	COG1047	Peptidyl-prolyl cis-trans
K5609_RS02340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5609_RS02350	COG1175	transmembrane transport
K5609_RS02355	COG0395	ABC-type sugar transport system, permease component
K5609_RS02370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5609_RS02375	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K5609_RS02380	COG0604	alcohol dehydrogenase
K5609_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
K5609_RS02380	COG3321	synthase
K5609_RS02385	COG2818	Glycosylase
K5609_RS02405	COG0151	Belongs to the GarS family
K5609_RS02410	COG0138	bifunctional purine biosynthesis protein purh
K5609_RS02450	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K5609_RS02460	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K5609_RS02465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5609_RS02490	COG0439	Biotin carboxylase
K5609_RS02495	COG0511	ligase activity, forming carbon-carbon bonds
K5609_RS02500	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K5609_RS02515	COG1309	transcriptional regulator
K5609_RS02520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5609_RS02535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K5609_RS02555	COG0784	Response regulator, receiver
K5609_RS02555	COG2205	protein histidine kinase activity
K5609_RS02570	COG1280	lysine exporter protein (LysE YggA)
K5609_RS02590	COG1917	Cupin 2, conserved barrel domain protein
K5609_RS02590	COG4977	sequence-specific DNA binding
K5609_RS02605	COG4232	protein-disulfide reductase activity
K5609_RS02615	COG3030	protein affecting phage T7 exclusion by the F plasmid
K5609_RS02630	COG0459	protein refolding
K5609_RS02635	COG0582	viral genome integration into host DNA
K5609_RS02665	COG1028	Short-chain dehydrogenase reductase Sdr
K5609_RS02675	COG1917	Cupin 2, conserved barrel domain protein
K5609_RS02690	COG0800	Aldolase
K5609_RS02695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5609_RS02710	COG1904	glucuronate isomerase
K5609_RS02740	COG2203	Gaf domain
K5609_RS02740	COG3706	GGDEF domain
K5609_RS02740	COG4251	negative regulation of phosphorylation
K5609_RS02740	COG5001	Diguanylate cyclase
K5609_RS02745	COG2197	response regulator
K5609_RS02750	COG4585	Histidine kinase
K5609_RS02755	COG0583	DNA-binding transcription factor activity
K5609_RS02775	COG0786	glutamate:sodium symporter activity
K5609_RS02795	COG0583	DNA-binding transcription factor activity
K5609_RS02840	COG2207	Transcriptional regulator
K5609_RS02845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5609_RS02850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5609_RS02855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5609_RS02855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5609_RS02855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5609_RS02860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5609_RS02860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5609_RS02860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5609_RS02895	COG1175	transmembrane transport
K5609_RS02900	COG0395	ABC-type sugar transport system, permease component
K5609_RS02915	COG3842	ATPase activity
K5609_RS02920	COG1609	Transcriptional regulator
K5609_RS02930	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K5609_RS02935	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
K5609_RS02950	COG1482	cell wall glycoprotein biosynthetic process
K5609_RS02960	COG0534	Mate efflux family protein
K5609_RS02970	COG1879	ABC-type sugar transport system periplasmic component
K5609_RS02980	COG0494	nUDIX hydrolase
K5609_RS03010	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K5609_RS03040	COG1509	lysine 2,3-aminomutase activity
K5609_RS03045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5609_RS03060	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K5609_RS03065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K5609_RS03070	COG1053	succinate dehydrogenase
K5609_RS03075	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K5609_RS03080	COG0471	metal ion transport
K5609_RS03080	COG0490	domain, Protein
K5609_RS03085	COG1511	domain protein
K5609_RS03085	COG3264	Mechanosensitive ion channel
K5609_RS03090	COG0688	phosphatidylethanolamine metabolic process
K5609_RS03095	COG1162	GTPase activity
K5609_RS03100	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K5609_RS03130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5609_RS03135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K5609_RS03135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K5609_RS03140	COG0802	atpase or kinase
K5609_RS03150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K5609_RS03155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5609_RS03160	COG1923	regulation of RNA biosynthetic process
K5609_RS03165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5609_RS03170	COG0330	HflC and HflK could
K5609_RS03175	COG0330	HflC and HflK could
K5609_RS03185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5609_RS03190	COG0142	geranyltranstransferase activity
K5609_RS03195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5609_RS03205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5609_RS03210	COG2966	Psort location CytoplasmicMembrane, score
K5609_RS03215	COG3610	response to peptide
K5609_RS03225	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K5609_RS03230	COG2967	ApaG domain
K5609_RS03235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K5609_RS03240	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K5609_RS03245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5609_RS03250	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K5609_RS03260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K5609_RS03265	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K5609_RS03270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5609_RS03280	COG0564	pseudouridine synthase activity
K5609_RS03285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5609_RS03310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K5609_RS03325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5609_RS03350	COG0028	Belongs to the TPP enzyme family
K5609_RS03355	COG0440	acetolactate synthase activity
K5609_RS03360	COG2199	diguanylate cyclase activity
K5609_RS03360	COG2200	EAL domain
K5609_RS03390	COG3409	Peptidoglycan-binding domain 1 protein
K5609_RS03390	COG3267	Type II secretory pathway component ExeA
K5609_RS03400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5609_RS03405	COG1459	type II secretion system
K5609_RS03415	COG2165	general secretion pathway protein
K5609_RS03450	COG1077	Cell shape determining protein MreB Mrl
K5609_RS03455	COG1792	Involved in formation and maintenance of cell shape
K5609_RS03460	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K5609_RS03465	COG0424	maF-like protein
K5609_RS03470	COG1530	ribonuclease E activity
K5609_RS03475	COG3164	Protein of unknown function
K5609_RS03480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K5609_RS03485	COG0312	modulator of DNA gyrase
K5609_RS03490	COG3028	Belongs to the UPF0307 family
K5609_RS03495	COG0312	modulator of DNA gyrase
K5609_RS03500	COG2239	Acts as a magnesium transporter
K5609_RS03505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5609_RS03510	COG1660	Displays ATPase and GTPase activities
K5609_RS03515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5609_RS03525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K5609_RS03530	COG1137	ATPase activity
K5609_RS03535	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K5609_RS03545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K5609_RS03550	COG0517	IMP dehydrogenase activity
K5609_RS03550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K5609_RS03560	COG1127	ABC transporter
K5609_RS03565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K5609_RS03570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K5609_RS03575	COG2854	intermembrane phospholipid transfer
K5609_RS03585	COG5007	Belongs to the BolA IbaG family
K5609_RS03590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5609_RS03595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5609_RS03600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5609_RS03610	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K5609_RS03615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5609_RS03620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5609_RS03625	COG0723	plastoquinol--plastocyanin reductase activity
K5609_RS03630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K5609_RS03635	COG2857	Cytochrome c1
K5609_RS03640	COG0625	glutathione transferase activity
K5609_RS03645	COG2969	positive regulation of protein catabolic process
K5609_RS03650	COG2823	Periplasmic or secreted lipoprotein
K5609_RS03660	COG0792	nuclease activity
K5609_RS03665	COG3107	peptidoglycan biosynthetic process
K5609_RS03670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K5609_RS03680	COG2001	Belongs to the MraZ family
K5609_RS03690	COG3116	cell division
K5609_RS03695	COG0768	penicillin binding
K5609_RS03700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5609_RS03705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5609_RS03710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5609_RS03715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5609_RS03720	COG0772	Belongs to the SEDS family
K5609_RS03725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K5609_RS03730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5609_RS03735	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5609_RS03740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K5609_RS03745	COG0849	cell division
K5609_RS03750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5609_RS03755	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K5609_RS03765	COG0739	heme binding
K5609_RS03765	COG1196	nuclear chromosome segregation
K5609_RS03765	COG0741	lytic transglycosylase activity
K5609_RS03770	COG0653	protein targeting
K5609_RS03780	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K5609_RS03790	COG0237	dephospho-CoA kinase activity
K5609_RS03800	COG1459	type II secretion system
K5609_RS03805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5609_RS03810	COG4969	Belongs to the N-Me-Phe pilin family
K5609_RS03815	COG0157	Belongs to the NadC ModD family
K5609_RS03820	COG3023	N-Acetylmuramoyl-L-alanine amidase
K5609_RS03830	COG2186	Transcriptional regulator
K5609_RS03835	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K5609_RS03840	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5609_RS03845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5609_RS03850	COG1752	Esterase of the alpha-beta hydrolase superfamily
K5609_RS03875	COG0004	ammonium transporteR
K5609_RS03880	COG1840	ABC-type Fe3 transport system, periplasmic component
K5609_RS03890	COG3842	ATPase activity
K5609_RS03895	COG1438	arginine binding
K5609_RS03900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5609_RS03905	COG0039	L-malate dehydrogenase activity
K5609_RS03910	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K5609_RS03915	COG0557	exoribonuclease II activity
K5609_RS03920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5609_RS03925	COG0360	Binds together with S18 to 16S ribosomal RNA
K5609_RS03930	COG2965	DNA replication, synthesis of RNA primer
K5609_RS03935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5609_RS03945	COG4134	Bacterial extracellular solute-binding protein
K5609_RS03950	COG4135	transport system, permease component
K5609_RS03955	COG4136	ATPase activity
K5609_RS03965	COG0305	Participates in initiation and elongation during chromosome replication
K5609_RS03970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5609_RS03975	COG0450	alkyl hydroperoxide reductase
K5609_RS03985	COG1216	Glycosyl transferase, family 2
K5609_RS04020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K5609_RS04045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5609_RS04055	COG1803	Methylglyoxal synthase
K5609_RS04060	COG2135	peptidase activity
K5609_RS04070	COG0469	pyruvate kinase activity
K5609_RS04075	COG0745	RESPONSE REGULATOR receiver
K5609_RS04085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K5609_RS04095	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
K5609_RS04105	COG0083	homoserine kinase activity
K5609_RS04110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K5609_RS04120	COG1946	Acyl-CoA thioesterase
K5609_RS04125	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K5609_RS04140	COG1115	amino acid carrier protein
K5609_RS04145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5609_RS04150	COG1678	Uncharacterized ACR, COG1678
K5609_RS04155	COG0189	ligase activity
K5609_RS04160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5609_RS04190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K5609_RS04195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K5609_RS04205	COG0191	fructose-bisphosphate aldolase activity
K5609_RS04220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5609_RS04225	COG1538	Outer membrane efflux protein
K5609_RS04230	COG2885	chlorophyll binding
K5609_RS04250	COG1879	ABC-type sugar transport system periplasmic component
K5609_RS04255	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5609_RS04260	COG1129	ABC transporter
K5609_RS04265	COG0673	inositol 2-dehydrogenase activity
K5609_RS04275	COG1609	Transcriptional regulator
K5609_RS04295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5609_RS04300	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K5609_RS04305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5609_RS04310	COG0217	transcriptional regulatory protein
K5609_RS04320	COG0577	efflux transmembrane transporter activity
K5609_RS04320	COG1136	(ABC) transporter
K5609_RS04325	COG1136	(ABC) transporter
K5609_RS04355	COG1609	Transcriptional regulator
K5609_RS04365	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5609_RS04370	COG3279	Response regulator of the LytR AlgR family
K5609_RS04375	COG3275	phosphorelay sensor kinase activity
K5609_RS04405	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K5609_RS04420	COG0006	proline dipeptidase activity
K5609_RS04425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5609_RS04430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5609_RS04455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K5609_RS04460	COG0509	glycine decarboxylation via glycine cleavage system
K5609_RS04465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5609_RS04465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5609_RS04510	COG1309	transcriptional regulator
K5609_RS04515	COG1012	belongs to the aldehyde dehydrogenase family
K5609_RS04520	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K5609_RS04525	COG0640	Transcriptional regulator
K5609_RS04530	COG0798	PFAM Bile acid sodium symporter
K5609_RS04535	COG0583	DNA-binding transcription factor activity
K5609_RS04540	COG3384	dioxygenase
K5609_RS04545	COG0435	Glutathione S-transferase
K5609_RS04555	COG0625	glutathione transferase activity
K5609_RS04575	COG0737	Belongs to the 5'-nucleotidase family
K5609_RS04580	COG0415	Belongs to the DNA photolyase family
K5609_RS04600	COG0110	maltose O-acetyltransferase activity
K5609_RS04605	COG3119	arylsulfatase activity
K5609_RS04630	COG0604	alcohol dehydrogenase
K5609_RS04685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5609_RS04695	COG0366	Alpha amylase catalytic
K5609_RS04700	COG0840	transmembrane signaling receptor activity
K5609_RS04730	COG0300	oxidoreductase activity
K5609_RS04735	COG2814	Major facilitator Superfamily
K5609_RS04755	COG0513	Belongs to the DEAD box helicase family
K5609_RS04795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K5609_RS04805	COG2201	protein-glutamate methylesterase activity
K5609_RS04815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K5609_RS04820	COG0243	molybdopterin cofactor binding
K5609_RS04855	COG4580	involved in the transport of maltose and maltodextrins
K5609_RS04865	COG0318	PFAM AMP-dependent synthetase and ligase
K5609_RS04905	COG0714	Associated with various cellular activities
K5609_RS04930	COG0789	Transcriptional regulator
K5609_RS04935	COG0667	Aldo Keto reductase
K5609_RS04940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5609_RS04945	COG0501	Belongs to the peptidase M48B family
K5609_RS04950	COG1704	LemA family
K5609_RS04955	COG2095	MarC family integral membrane protein
K5609_RS04985	COG2207	Transcriptional regulator
K5609_RS04985	COG1917	Cupin 2, conserved barrel domain protein
K5609_RS04990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K5609_RS05000	COG1028	Short-chain dehydrogenase reductase Sdr
K5609_RS05005	COG2067	long-chain fatty acid transport protein
K5609_RS05030	COG0346	lactoylglutathione lyase activity
K5609_RS05035	COG0415	Belongs to the DNA photolyase family
K5609_RS05040	COG2217	Heavy metal translocating P-type atpase
K5609_RS05045	COG0789	Transcriptional regulator
K5609_RS05055	COG3123	guanosine phosphorylase activity
K5609_RS05060	COG3530	Putative quorum-sensing-regulated virulence factor
K5609_RS05065	COG1278	Cold shock
K5609_RS05075	COG1132	(ABC) transporter
K5609_RS05080	COG0513	Belongs to the DEAD box helicase family
K5609_RS05085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K5609_RS05095	COG1280	lysine exporter protein (LysE YggA)
K5609_RS05105	COG0564	pseudouridine synthase activity
K5609_RS05110	COG1966	Carbon starvation protein
K5609_RS05120	COG3275	phosphorelay sensor kinase activity
K5609_RS05125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5609_RS05130	COG0287	Prephenate dehydrogenase
K5609_RS05130	COG1605	Chorismate mutase
K5609_RS05145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K5609_RS05165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5609_RS05170	COG1666	GTP binding
K5609_RS05185	COG2211	Major facilitator Superfamily
K5609_RS05200	COG2813	Specifically methylates the guanine in position
K5609_RS05210	COG0271	Belongs to the BolA IbaG family
K5609_RS05220	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5609_RS05230	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5609_RS05235	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5609_RS05240	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5609_RS05245	COG2871	sodium ion transport
K5609_RS05250	COG1477	protein flavinylation
K5609_RS05270	COG0405	Gamma-glutamyltransferase
K5609_RS05285	COG0281	malic enzyme
K5609_RS05295	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K5609_RS05305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K5609_RS05310	COG0667	Aldo Keto reductase
K5609_RS05345	COG0557	exoribonuclease II activity
K5609_RS05350	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K5609_RS05370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5609_RS05380	COG2010	Cytochrome c
K5609_RS05385	COG1979	alcohol dehydrogenase
K5609_RS05395	COG0583	DNA-binding transcription factor activity
K5609_RS05430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5609_RS05440	COG0583	DNA-binding transcription factor activity
K5609_RS05500	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K5609_RS05530	COG3290	protein histidine kinase activity
K5609_RS05535	COG4565	transcriptional regulatory protein
K5609_RS05545	COG0583	DNA-binding transcription factor activity
K5609_RS05550	COG0534	Mate efflux family protein
K5609_RS05555	COG0604	alcohol dehydrogenase
K5609_RS05555	COG3321	synthase
K5609_RS05565	COG1024	Enoyl-CoA hydratase
K5609_RS05585	COG1162	GTPase activity
K5609_RS05590	COG1741	Belongs to the pirin family
K5609_RS05595	COG0784	Response regulator, receiver
K5609_RS05595	COG5002	protein histidine kinase activity
K5609_RS05595	COG2205	protein histidine kinase activity
K5609_RS05620	COG0697	spore germination
K5609_RS05625	COG4628	conserved protein (DUF2132)
K5609_RS05635	COG1054	Belongs to the UPF0176 family
K5609_RS05640	COG0784	Response regulator, receiver
K5609_RS05640	COG0835	chemotaxis
K5609_RS05650	COG1595	DNA-templated transcription, initiation
K5609_RS05665	COG0300	oxidoreductase activity
K5609_RS05680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K5609_RS05700	COG1902	pentaerythritol trinitrate reductase activity
K5609_RS05725	COG0475	glutathione-regulated potassium exporter activity
K5609_RS05725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K5609_RS05730	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5609_RS05740	COG1597	lipid kinase activity
K5609_RS05790	COG0786	glutamate:sodium symporter activity
K5609_RS05795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5609_RS05800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5609_RS05825	COG0745	RESPONSE REGULATOR receiver
K5609_RS05840	COG4269	membrane
K5609_RS05845	COG0501	Belongs to the peptidase M48B family
K5609_RS05860	COG2182	Extracellular solute-binding protein
K5609_RS05885	COG2199	diguanylate cyclase activity
K5609_RS05885	COG2203	Gaf domain
K5609_RS05895	COG1061	Type III restriction enzyme res subunit
K5609_RS05930	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
K5609_RS05940	COG1253	flavin adenine dinucleotide binding
K5609_RS05950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K5609_RS05955	COG2867	negative regulation of translational initiation
K5609_RS05960	COG2914	Belongs to the UPF0125 (RnfH) family
K5609_RS05970	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5609_RS05975	COG0497	DNA recombination
K5609_RS05980	COG3867	Arabinogalactan endo-beta-1,4-galactanase
K5609_RS05985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5609_RS05990	COG3842	ATPase activity
K5609_RS05995	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5609_RS06000	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5609_RS06005	COG2814	Major facilitator Superfamily
K5609_RS06015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5609_RS06025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K5609_RS06030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5609_RS06035	COG3313	Fe-S protein
K5609_RS06040	COG0288	reversible hydration of carbon dioxide
K5609_RS06045	COG1301	dicarboxylic acid transport
K5609_RS06050	COG0443	Heat shock 70 kDa protein
K5609_RS06055	COG0484	heat shock protein binding
K5609_RS06060	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
K5609_RS06075	COG0545	Peptidyl-prolyl cis-trans isomerase
K5609_RS06080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5609_RS06085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5609_RS06090	COG1116	anion transmembrane transporter activity
K5609_RS06095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K5609_RS06110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5609_RS06115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5609_RS06120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5609_RS06130	COG1534	Rna-binding protein
K5609_RS06135	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K5609_RS06140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5609_RS06145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K5609_RS06150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5609_RS06155	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5609_RS06170	COG0779	Required for maturation of 30S ribosomal subunits
K5609_RS06175	COG0195	Participates in both transcription termination and antitermination
K5609_RS06180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K5609_RS06180	COG3064	Membrane
K5609_RS06190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K5609_RS06195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5609_RS06205	COG0590	tRNA wobble adenosine to inosine editing
K5609_RS06210	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K5609_RS06215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5609_RS06215	COG0047	phosphoribosylformylglycinamidine synthase activity
K5609_RS06235	COG3021	interspecies interaction between organisms
K5609_RS06240	COG0741	lytic transglycosylase activity
K5609_RS06240	COG1388	LysM domain
K5609_RS06245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5609_RS06250	COG2226	methyltransferase
K5609_RS06255	COG0328	RNA-DNA hybrid ribonuclease activity
K5609_RS06290	COG0784	Response regulator, receiver
K5609_RS06290	COG3437	response regulator, receiver
K5609_RS06295	COG1960	acyl-CoA dehydrogenase activity
K5609_RS06300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K5609_RS06305	COG0121	glutamine amidotransferase
K5609_RS06310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K5609_RS06315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5609_RS06320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5609_RS06340	COG1393	Belongs to the ArsC family
K5609_RS06345	COG4783	chaperone-mediated protein folding
K5609_RS06360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K5609_RS06365	COG2716	regulation of RNA biosynthetic process
K5609_RS06370	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K5609_RS06400	COG1393	Belongs to the ArsC family
K5609_RS06405	COG2190	(PTS) system
K5609_RS06410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5609_RS06415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5609_RS06420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5609_RS06425	COG2770	Histidine kinase
K5609_RS06425	COG3437	response regulator, receiver
K5609_RS06440	COG1196	nuclear chromosome segregation
K5609_RS06445	COG3115	cell septum assembly
K5609_RS06450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5609_RS06455	COG2116	formate transmembrane transporter activity
K5609_RS06465	COG1696	Membrane protein involved in D-alanine export
K5609_RS06510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5609_RS06570	COG0583	DNA-binding transcription factor activity
K5609_RS06580	COG0765	amino acid transport
K5609_RS06585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5609_RS06605	COG0523	cobalamin synthesis protein
K5609_RS06630	COG1090	epimerase
K5609_RS06645	COG0628	permease
K5609_RS06650	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5609_RS06690	COG0280	phosphate acetyltransferase
K5609_RS06690	COG0857	belongs to the CobB CobQ family
K5609_RS06695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5609_RS06705	COG2226	methyltransferase
K5609_RS06710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5609_RS06715	COG1882	Formate acetyltransferase
K5609_RS06730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5609_RS06740	COG4160	amino acid transport
K5609_RS06745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K5609_RS06755	COG0545	Peptidyl-prolyl cis-trans isomerase
K5609_RS06780	COG0788	formyltetrahydrofolate deformylase activity
K5609_RS06785	COG3012	SEC-C Motif Domain Protein
K5609_RS06790	COG0784	Response regulator, receiver
K5609_RS06790	COG3437	response regulator, receiver
K5609_RS06795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K5609_RS06800	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K5609_RS06815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5609_RS06825	COG1028	Short-chain dehydrogenase reductase Sdr
K5609_RS06830	COG0583	DNA-binding transcription factor activity
K5609_RS06835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K5609_RS06855	COG0300	oxidoreductase activity
K5609_RS06870	COG0583	DNA-binding transcription factor activity
K5609_RS06880	COG1454	alcohol dehydrogenase
K5609_RS06880	COG1012	belongs to the aldehyde dehydrogenase family
K5609_RS06890	COG0601	transmembrane transport
K5609_RS06895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5609_RS06900	COG0444	Belongs to the ABC transporter superfamily
K5609_RS06965	COG2084	Dehydrogenase
K5609_RS06975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5609_RS06980	COG1733	regulation of RNA biosynthetic process
K5609_RS06990	COG1902	pentaerythritol trinitrate reductase activity
K5609_RS07025	COG4266	Belongs to the allantoicase family
K5609_RS07040	COG0765	amino acid transport
K5609_RS07045	COG0765	amino acid transport
K5609_RS07065	COG0745	RESPONSE REGULATOR receiver
K5609_RS07070	COG5002	protein histidine kinase activity
K5609_RS07140	COG0514	ATP-dependent DNA helicase (RecQ)
K5609_RS07220	COG2199	diguanylate cyclase activity
K5609_RS07220	COG2203	Gaf domain
K5609_RS07250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5609_RS07275	COG1132	(ABC) transporter
K5609_RS07280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5609_RS07305	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K5609_RS07310	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
K5609_RS07315	COG3454	Phosphonate metabolism
K5609_RS07320	COG4778	phosphonate C-P lyase system protein PhnL
K5609_RS07325	COG4107	phosphonate C-P lyase system protein PhnK
K5609_RS07330	COG3627	carbon phosphorus lyase activity
K5609_RS07335	COG3626	phosphonate metabolism
K5609_RS07340	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
K5609_RS07345	COG3624	Phosphonate C-P lyase system protein PhnG
K5609_RS07350	COG2188	Transcriptional regulator
K5609_RS07355	COG3639	organic phosphonate transmembrane transporter activity
K5609_RS07360	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
K5609_RS07365	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K5609_RS07375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5609_RS07380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5609_RS07390	COG0561	phosphatase activity
K5609_RS07445	COG3768	UPF0283 membrane protein
K5609_RS07450	COG3106	COG3106 Predicted ATPase
K5609_RS07455	COG0366	Alpha amylase catalytic
K5609_RS07460	COG2814	Major facilitator Superfamily
K5609_RS07465	COG0737	Belongs to the 5'-nucleotidase family
K5609_RS07475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5609_RS07485	COG1278	Cold shock
K5609_RS07490	COG3148	PFAM DTW domain containing protein
K5609_RS07535	COG2207	Transcriptional regulator
K5609_RS07540	COG0702	epimerase
K5609_RS07545	COG0667	Aldo Keto reductase
K5609_RS07550	COG1643	Atp-dependent helicase
K5609_RS07555	COG3038	cytochrome b561
K5609_RS07560	COG2949	membrane
K5609_RS07575	COG0343	queuine tRNA-ribosyltransferase activity
K5609_RS07580	COG1862	Preprotein translocase
K5609_RS07585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5609_RS07590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5609_RS07625	COG1959	2 iron, 2 sulfur cluster binding
K5609_RS07635	COG0822	iron-sulfur transferase activity
K5609_RS07640	COG0316	Belongs to the HesB IscA family
K5609_RS07645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K5609_RS07660	COG2975	iron-sulfur cluster assembly
K5609_RS07670	COG0105	UTP biosynthetic process
K5609_RS07675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5609_RS07685	COG1426	Protein conserved in bacteria
K5609_RS07690	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K5609_RS07695	COG0124	histidyl-tRNA synthetase
K5609_RS07705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5609_RS07710	COG1160	GTP binding
K5609_RS07715	COG1645	bacterial-type flagellum-dependent swarming motility
K5609_RS07720	COG0596	Alpha beta hydrolase
K5609_RS07725	COG1570	exodeoxyribonuclease VII activity
K5609_RS07730	COG0516	GMP reductase activity
K5609_RS07730	COG0517	IMP dehydrogenase activity
K5609_RS07735	COG0519	Catalyzes the synthesis of GMP from XMP
K5609_RS07735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5609_RS07740	COG2814	Major facilitator Superfamily
K5609_RS07745	COG0583	DNA-binding transcription factor activity
K5609_RS07750	COG2363	Small membrane protein
K5609_RS07755	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
K5609_RS07760	COG0473	3-isopropylmalate dehydrogenase activity
K5609_RS07775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5609_RS07780	COG1611	Belongs to the LOG family
K5609_RS07795	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K5609_RS07795	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K5609_RS07805	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K5609_RS07820	COG3098	single-species biofilm formation
K5609_RS07830	COG4580	involved in the transport of maltose and maltodextrins
K5609_RS07855	COG2171	N-acyltransferase activity
K5609_RS07860	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K5609_RS07865	COG0024	Methionine aminopeptidase
K5609_RS07870	COG0052	Belongs to the universal ribosomal protein uS2 family
K5609_RS07875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5609_RS07880	COG0528	UMP kinase activity
K5609_RS07885	COG0233	cytoplasmic translational termination
K5609_RS07890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5609_RS07895	COG0575	Belongs to the CDS family
K5609_RS07900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K5609_RS07920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5609_RS07925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5609_RS07930	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5609_RS07935	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5609_RS07945	COG0587	DNA-directed DNA polymerase activity
K5609_RS07955	COG0037	tRNA processing
K5609_RS07960	COG2199	diguanylate cyclase activity
K5609_RS07960	COG2203	Gaf domain
K5609_RS07970	COG0442	prolyl-tRNA aminoacylation
K5609_RS07975	COG0110	maltose O-acetyltransferase activity
K5609_RS07980	COG1720	tRNA m6t6A37 methyltransferase activity
K5609_RS07990	COG0784	Response regulator, receiver
K5609_RS07990	COG2205	protein histidine kinase activity
K5609_RS07995	COG0840	transmembrane signaling receptor activity
K5609_RS08030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5609_RS08040	COG2350	Protein conserved in bacteria
K5609_RS08045	COG2917	probably involved in intracellular septation
K5609_RS08055	COG0133	tryptophan synthase activity
K5609_RS08060	COG0134	indole-3-glycerol-phosphate synthase activity
K5609_RS08060	COG0135	phosphoribosylanthranilate isomerase activity
K5609_RS08065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K5609_RS08070	COG0512	Glutamine amidotransferase of anthranilate synthase
K5609_RS08070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K5609_RS08075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K5609_RS08080	COG0613	PHP domain protein
K5609_RS08085	COG0009	L-threonylcarbamoyladenylate synthase
K5609_RS08095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5609_RS08100	COG1187	pseudouridine synthase activity
K5609_RS08115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5609_RS08120	COG0215	cysteine-tRNA ligase activity
K5609_RS08130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K5609_RS08135	COG2985	domain, Protein
K5609_RS08170	COG2165	general secretion pathway protein
K5609_RS08175	COG0544	peptidyl-prolyl cis-trans isomerase activity
K5609_RS08180	COG0740	serine-type endopeptidase activity
K5609_RS08185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5609_RS08200	COG1320	monovalent cation:proton antiporter activity
K5609_RS08205	COG2212	antiporter activity
K5609_RS08210	COG1863	multisubunit Na H antiporter MnhE subunit
K5609_RS08215	COG0651	ATP synthesis coupled electron transport
K5609_RS08220	COG1006	Multisubunit Na H antiporter MnhC subunit
K5609_RS08225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K5609_RS08225	COG2111	Na H antiporter
K5609_RS08250	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K5609_RS08310	COG0778	Nitroreductase
K5609_RS08320	COG0402	S-adenosylhomocysteine deaminase activity
K5609_RS08325	COG2351	hydroxyisourate hydrolase activity
K5609_RS08340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K5609_RS08345	COG2080	2 iron, 2 sulfur cluster binding
K5609_RS08360	COG2233	PERMEase
K5609_RS08425	COG0737	Belongs to the 5'-nucleotidase family
K5609_RS08430	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5609_RS08435	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5609_RS08440	COG3845	ABC transporter
K5609_RS08485	COG0826	peptidase U32
K5609_RS08500	COG0488	(ABC) transporter
K5609_RS08580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5609_RS08590	COG0110	maltose O-acetyltransferase activity
K5609_RS08600	COG2824	Alkylphosphonate utilization operon protein PhnA
K5609_RS08640	COG2204	response regulator
K5609_RS08650	COG0500	methyltransferase
K5609_RS08665	COG0438	transferase activity, transferring glycosyl groups
K5609_RS08680	COG0601	transmembrane transport
K5609_RS08685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5609_RS08690	COG4172	Belongs to the ABC transporter superfamily
K5609_RS08700	COG1335	isochorismatase
K5609_RS08705	COG1215	transferase activity, transferring glycosyl groups
K5609_RS08715	COG1216	Glycosyl transferase, family 2
K5609_RS08720	COG1215	transferase activity, transferring glycosyl groups
K5609_RS08735	COG0438	transferase activity, transferring glycosyl groups
K5609_RS08750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5609_RS08755	COG2501	S4 domain
K5609_RS08795	COG5001	Diguanylate cyclase
K5609_RS08800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5609_RS08825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5609_RS08850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5609_RS08865	COG2719	SpoVR family
K5609_RS08870	COG2718	Belongs to the UPF0229 family
K5609_RS08875	COG2766	serine protein kinase
K5609_RS08880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5609_RS08905	COG0604	alcohol dehydrogenase
K5609_RS08910	COG0583	DNA-binding transcription factor activity
K5609_RS08930	COG2186	Transcriptional regulator
K5609_RS08940	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
K5609_RS08965	COG1917	Cupin 2, conserved barrel domain protein
K5609_RS08975	COG0800	Aldolase
K5609_RS08980	COG0456	acetyltransferase
K5609_RS08990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5609_RS09000	COG2119	membrane
K5609_RS09015	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5609_RS09045	COG0513	Belongs to the DEAD box helicase family
K5609_RS09060	COG0066	3-isopropylmalate dehydratase activity
K5609_RS09065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K5609_RS09070	COG0366	Alpha amylase catalytic
K5609_RS09100	COG2200	EAL domain
K5609_RS09115	COG0420	3'-5' exonuclease activity
K5609_RS09120	COG0419	ATPase involved in DNA repair
K5609_RS09135	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K5609_RS09145	COG0730	response to heat
K5609_RS09150	COG1199	ATP-dependent helicase activity
K5609_RS09170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5609_RS09175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5609_RS09180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5609_RS09185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5609_RS09195	COG0367	asparagine synthase
K5609_RS09205	COG0647	UMP catabolic process
K5609_RS09210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5609_RS09220	COG1560	Kdo2-lipid A biosynthetic process
K5609_RS09250	COG0589	response to stress
K5609_RS09260	COG0622	Phosphoesterase
K5609_RS09280	COG2824	Alkylphosphonate utilization operon protein PhnA
K5609_RS09305	COG2105	PFAM AIG2 family protein
K5609_RS09310	COG0659	secondary active sulfate transmembrane transporter activity
K5609_RS09320	COG0140	phosphoribosyl-ATP diphosphatase activity
K5609_RS09320	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K5609_RS09325	COG0107	imidazoleglycerol-phosphate synthase activity
K5609_RS09330	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K5609_RS09335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K5609_RS09340	COG0131	Imidazoleglycerol-phosphate dehydratase
K5609_RS09340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K5609_RS09345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5609_RS09350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K5609_RS09355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K5609_RS09365	COG1199	ATP-dependent helicase activity
K5609_RS09370	COG1214	PFAM Peptidase M22, glycoprotease
K5609_RS09380	COG2226	methyltransferase
K5609_RS09380	COG1073	alpha beta
K5609_RS09385	COG0318	PFAM AMP-dependent synthetase and ligase
K5609_RS09390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K5609_RS09395	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K5609_RS09400	COG2894	cell division
K5609_RS09405	COG0850	regulation of cytokinetic process
K5609_RS09415	COG2951	lytic endotransglycosylase activity
K5609_RS09420	COG0179	Fumarylacetoacetate (FAA) hydrolase
K5609_RS09425	COG2983	Belongs to the UPF0260 family
K5609_RS09430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K5609_RS09435	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K5609_RS09440	COG2186	Transcriptional regulator
K5609_RS09450	COG2119	membrane
K5609_RS09455	COG0023	Translation Initiation Factor
K5609_RS09475	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K5609_RS09480	COG1846	Transcriptional regulator
K5609_RS09480	COG1940	carbohydrate kinase activity
K5609_RS09485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K5609_RS09490	COG0363	glucosamine-6-phosphate deaminase activity
K5609_RS09495	COG1263	PTS System
K5609_RS09495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5609_RS09515	COG1280	lysine exporter protein (LysE YggA)
K5609_RS09530	COG3604	Transcriptional regulator
K5609_RS09545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5609_RS09550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5609_RS09585	COG2850	peptidyl-arginine hydroxylation
K5609_RS09590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5609_RS09605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5609_RS09610	COG0326	Molecular chaperone. Has ATPase activity
K5609_RS09615	COG2182	Extracellular solute-binding protein
K5609_RS09620	COG3706	GGDEF domain
K5609_RS09630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K5609_RS09640	COG0488	(ABC) transporter
K5609_RS09655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5609_RS09660	COG2915	High frequency lysogenization protein hflD homolog
K5609_RS09665	COG0482	sulfurtransferase activity
K5609_RS09670	COG1187	pseudouridine synthase activity
K5609_RS09680	COG1278	Cold shock
K5609_RS09685	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K5609_RS09690	COG0542	response to heat
K5609_RS09695	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K5609_RS09700	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K5609_RS09705	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K5609_RS09710	COG0492	ferredoxin-NADP+ reductase activity
K5609_RS09720	COG1674	ftsk spoiiie
K5609_RS09720	COG0531	amino acid
K5609_RS09725	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K5609_RS09730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5609_RS09735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5609_RS09740	COG2920	part of a sulfur-relay system
K5609_RS09745	COG1289	transmembrane transporter activity
K5609_RS09750	COG0670	Belongs to the BI1 family
K5609_RS09755	COG1227	inorganic diphosphatase activity
K5609_RS09760	COG0067	glutamate synthase
K5609_RS09760	COG0070	glutamate synthase
K5609_RS09760	COG0069	glutamate synthase activity
K5609_RS09765	COG0493	'glutamate synthase
K5609_RS09775	COG2197	response regulator
K5609_RS09825	COG1609	Transcriptional regulator
K5609_RS09830	COG1472	Belongs to the glycosyl hydrolase 3 family
K5609_RS09850	COG1116	anion transmembrane transporter activity
K5609_RS09865	COG4770	biotin carboxylase activity
K5609_RS09895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5609_RS09925	COG2807	transmembrane transport
K5609_RS09960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5609_RS09975	COG0583	DNA-binding transcription factor activity
K5609_RS09980	COG2814	Major facilitator Superfamily
K5609_RS10000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5609_RS10005	COG0517	IMP dehydrogenase activity
K5609_RS10005	COG0516	GMP reductase activity
K5609_RS10020	COG3142	Participates in the control of copper homeostasis
K5609_RS10025	COG0584	glycerophosphoryl diester phosphodiesterase
K5609_RS10040	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K5609_RS10050	COG0583	DNA-binding transcription factor activity
K5609_RS10055	COG1028	Short-chain dehydrogenase reductase Sdr
K5609_RS10065	COG0616	signal peptide processing
K5609_RS10070	COG3724	N-succinylarginine dihydrolase activity
K5609_RS10125	COG2855	membrane
K5609_RS10130	COG1752	Esterase of the alpha-beta hydrolase superfamily
K5609_RS10145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5609_RS10150	COG0632	four-way junction helicase activity
K5609_RS10155	COG2255	four-way junction helicase activity
K5609_RS10160	COG0824	Thioesterase
K5609_RS10165	COG0811	peptide transport
K5609_RS10180	COG0823	Involved in the tonB-independent uptake of proteins
K5609_RS10185	COG2885	chlorophyll binding
K5609_RS10190	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K5609_RS10225	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K5609_RS10235	COG0676	glucose-6-phosphate 1-epimerase activity
K5609_RS10245	COG1640	4-alpha-glucanotransferase
K5609_RS10250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K5609_RS10260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5609_RS10270	COG3139	Protein of unknown function (DUF1315)
K5609_RS10275	COG0252	asparaginase activity
K5609_RS10280	COG0616	signal peptide processing
K5609_RS10285	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5609_RS10285	COG1902	pentaerythritol trinitrate reductase activity
K5609_RS10290	COG0778	Nitroreductase
K5609_RS10305	COG0017	Asparaginyl-tRNA synthetase
K5609_RS10315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K5609_RS10320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K5609_RS10325	COG0156	8-amino-7-oxononanoate synthase activity
K5609_RS10335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K5609_RS10340	COG0501	Belongs to the peptidase M48B family
K5609_RS10355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5609_RS10360	COG1763	Mo-molybdopterin cofactor biosynthetic process
K5609_RS10365	COG0729	surface antigen
K5609_RS10370	COG2911	Protein conserved in bacteria
K5609_RS10380	COG2211	Major facilitator Superfamily
K5609_RS10385	COG3118	belongs to the thioredoxin family
K5609_RS10390	COG0745	RESPONSE REGULATOR receiver
K5609_RS10400	COG1322	Protein conserved in bacteria
K5609_RS10405	COG0366	Alpha amylase catalytic
K5609_RS10410	COG3706	GGDEF domain
K5609_RS10430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5609_RS10445	COG0163	prenyltransferase activity
K5609_RS10450	COG0735	belongs to the Fur family
K5609_RS10460	COG0741	lytic transglycosylase activity
K5609_RS10480	COG0596	Alpha beta hydrolase
K5609_RS10485	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K5609_RS10490	COG0033	Phosphoglucomutase
K5609_RS10495	COG0058	SHG alpha-glucan phosphorylase activity
K5609_RS10500	COG2988	succinylglutamate desuccinylase activity
K5609_RS10505	COG0277	FAD linked oxidase domain protein
K5609_RS10505	COG0247	lactate metabolic process
K5609_RS10510	COG2050	protein possibly involved in aromatic compounds catabolism
K5609_RS10515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5609_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
K5609_RS10570	COG0116	Belongs to the methyltransferase superfamily
K5609_RS10570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5609_RS10580	COG0488	(ABC) transporter
K5609_RS10590	COG3130	regulation of translation
K5609_RS10595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5609_RS10600	COG1067	ATP-dependent peptidase activity
K5609_RS10605	COG2056	Na+-H+ antiporter family
K5609_RS10610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5609_RS10625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5609_RS10630	COG4660	Part of a membrane complex involved in electron transport
K5609_RS10635	COG4659	FMN binding
K5609_RS10640	COG4658	electron transport chain
K5609_RS10645	COG4656	Part of a membrane complex involved in electron transport
K5609_RS10655	COG4657	Part of a membrane complex involved in electron transport
K5609_RS10660	COG1328	CTP reductase activity
K5609_RS10665	COG0602	queuosine metabolic process
K5609_RS10670	COG2199	diguanylate cyclase activity
K5609_RS10670	COG2200	EAL domain
K5609_RS10670	COG2202	Pas domain
K5609_RS10700	COG0556	nucleotide-excision repair
K5609_RS10705	COG0149	triose-phosphate isomerase activity
K5609_RS10710	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K5609_RS10715	COG1448	Aminotransferase
K5609_RS10725	COG3437	response regulator, receiver
K5609_RS10725	COG0784	Response regulator, receiver
K5609_RS10735	COG0653	protein targeting
K5609_RS10745	COG3046	protein related to deoxyribodipyrimidine photolyase
K5609_RS10805	COG3437	response regulator, receiver
K5609_RS10810	COG3437	response regulator, receiver
K5609_RS10815	COG3278	Belongs to the heme-copper respiratory oxidase family
K5609_RS10830	COG2010	Cytochrome c
K5609_RS10840	COG2217	Heavy metal translocating P-type atpase
K5609_RS10855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5609_RS10860	COG0589	response to stress
K5609_RS10865	COG0037	tRNA processing
K5609_RS10870	COG2992	FlgJ-related protein
K5609_RS10875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5609_RS10880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5609_RS10885	COG4597	amino acid ABC transporter
K5609_RS10890	COG0765	amino acid transport
K5609_RS10895	COG1126	abc transporter atp-binding protein
K5609_RS10900	COG0776	regulation of translation
K5609_RS10905	COG0072	phenylalanine-tRNA ligase activity
K5609_RS10905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5609_RS10910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5609_RS10915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5609_RS10920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5609_RS10925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5609_RS10930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5609_RS10940	COG0307	riboflavin synthase, alpha
K5609_RS10945	COG0534	Mate efflux family protein
K5609_RS10965	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K5609_RS11010	COG4657	Part of a membrane complex involved in electron transport
K5609_RS11015	COG2878	Part of a membrane complex involved in electron transport
K5609_RS11020	COG4656	Part of a membrane complex involved in electron transport
K5609_RS11025	COG4658	electron transport chain
K5609_RS11045	COG0716	FMN binding
K5609_RS11065	COG4303	Ethanolamine ammonia lyase large subunit
K5609_RS11075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K5609_RS11085	COG2207	Transcriptional regulator
K5609_RS11110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5609_RS11125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5609_RS11130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5609_RS11175	COG1228	amidohydrolase
K5609_RS11200	COG3383	formate dehydrogenase (NAD+) activity
K5609_RS11235	COG2814	Major facilitator Superfamily
K5609_RS11270	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
K5609_RS11280	COG1063	alcohol dehydrogenase
K5609_RS11285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5609_RS11285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5609_RS11315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5609_RS11330	COG0038	chloride channel
K5609_RS11340	COG1012	belongs to the aldehyde dehydrogenase family
K5609_RS11355	COG3681	Belongs to the UPF0597 family
K5609_RS11360	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K5609_RS11375	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K5609_RS11380	COG1956	GAF domain-containing protein
K5609_RS11385	COG3141	response to X-ray
K5609_RS11395	COG2995	paraquat-inducible protein a
K5609_RS11400	COG3008	intermembrane lipid transfer
K5609_RS11405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5609_RS11405	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K5609_RS11410	COG0084	hydrolase, TatD family'
K5609_RS11420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5609_RS11425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5609_RS11430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5609_RS11435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5609_RS11440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5609_RS11455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5609_RS11460	COG0416	fatty acid biosynthetic process
K5609_RS11465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5609_RS11470	COG1399	metal-binding, possibly nucleic acid-binding protein
K5609_RS11485	COG1530	ribonuclease E activity
K5609_RS11500	COG0572	uridine kinase
K5609_RS11505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5609_RS11505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5609_RS11510	COG1254	Belongs to the acylphosphatase family
K5609_RS11525	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K5609_RS11540	COG0314	molybdopterin synthase activity
K5609_RS11545	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K5609_RS11550	COG0315	cyclic pyranopterin monophosphate synthase activity
K5609_RS11555	COG0521	Mo-molybdopterin cofactor biosynthetic process
K5609_RS11560	COG0746	molybdenum cofactor guanylyltransferase activity
K5609_RS11570	COG3005	denitrification pathway
K5609_RS11580	COG0243	molybdopterin cofactor binding
K5609_RS11590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5609_RS11590	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5609_RS11595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K5609_RS11600	COG3850	Histidine kinase
K5609_RS11605	COG2197	response regulator
K5609_RS11610	COG1032	radical SAM domain protein
K5609_RS11615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5609_RS11625	COG2223	nitrite transmembrane transporter activity
K5609_RS11645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5609_RS11675	COG0583	DNA-binding transcription factor activity
K5609_RS11685	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K5609_RS11695	COG2985	domain, Protein
K5609_RS11705	COG0837	glucose binding
K5609_RS11710	COG1737	Transcriptional regulator
K5609_RS11715	COG1960	acyl-CoA dehydrogenase activity
K5609_RS11735	COG3220	belongs to the UPF0276 family
K5609_RS11750	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K5609_RS11750	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K5609_RS11765	COG1760	l-serine dehydratase
K5609_RS11770	COG2010	Cytochrome c
K5609_RS11785	COG0668	transmembrane transport
K5609_RS11810	COG3706	GGDEF domain
K5609_RS11815	COG0583	DNA-binding transcription factor activity
K5609_RS11825	COG4181	ATPase activity
K5609_RS11840	COG0167	dihydroorotate dehydrogenase activity
K5609_RS11845	COG2902	Dehydrogenase
K5609_RS11855	COG0308	aminopeptidase N
K5609_RS11860	COG0733	neurotransmitter:sodium symporter activity
K5609_RS11865	COG2027	D-alanyl-D-alanine carboxypeptidase
K5609_RS11870	COG0513	Belongs to the DEAD box helicase family
K5609_RS11875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K5609_RS11890	COG1643	Atp-dependent helicase
K5609_RS11895	COG0517	IMP dehydrogenase activity
K5609_RS11895	COG0617	tRNA 3'-terminal CCA addition
K5609_RS11895	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K5609_RS11900	COG0418	dihydroorotase activity
K5609_RS11915	COG2925	Exonuclease
K5609_RS11925	COG3345	alpha-galactosidase
K5609_RS11935	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K5609_RS11950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K5609_RS11965	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K5609_RS11980	COG0587	DNA-directed DNA polymerase activity
K5609_RS11985	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5609_RS12000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5609_RS12035	COG0517	IMP dehydrogenase activity
K5609_RS12065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5609_RS12075	COG1028	Short-chain dehydrogenase reductase Sdr
K5609_RS12090	COG1187	pseudouridine synthase activity
K5609_RS12120	COG0205	6-phosphofructokinase activity
K5609_RS12135	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K5609_RS12140	COG0045	succinate-CoA ligase (ADP-forming) activity
K5609_RS12145	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5609_RS12150	COG0567	Dehydrogenase, E1 component
K5609_RS12155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K5609_RS12165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K5609_RS12175	COG0372	Belongs to the citrate synthase family
K5609_RS12190	COG2835	tetraacyldisaccharide 4'-kinase activity
K5609_RS12195	COG1663	tetraacyldisaccharide 4'-kinase activity
K5609_RS12200	COG1132	(ABC) transporter
K5609_RS12205	COG0658	competence protein
K5609_RS12205	COG2333	competence protein COMEC
K5609_RS12215	COG4591	ABC-type transport system involved in lipoprotein release permease component
K5609_RS12220	COG1136	(ABC) transporter
K5609_RS12225	COG4591	ABC-type transport system involved in lipoprotein release permease component
K5609_RS12235	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5609_RS12255	COG1252	NADH dehydrogenase
K5609_RS12265	COG1472	Belongs to the glycosyl hydrolase 3 family
K5609_RS12300	COG3842	ATPase activity
K5609_RS12305	COG3833	ABC-type maltose transport systems, permease component
K5609_RS12310	COG1175	transmembrane transport
K5609_RS12315	COG2182	Extracellular solute-binding protein
K5609_RS12320	COG3081	Nucleoid-associated protein
K5609_RS12330	COG3083	sulfuric ester hydrolase activity
K5609_RS12355	COG0848	biopolymer transport protein
K5609_RS12360	COG0811	peptide transport
K5609_RS12365	COG0811	peptide transport
K5609_RS12375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5609_RS12380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K5609_RS12385	COG1120	ATPase activity
K5609_RS12395	COG4774	siderophore transport
K5609_RS12400	COG3708	Transcriptional regulator
K5609_RS12400	COG2207	Transcriptional regulator
K5609_RS12425	COG0745	RESPONSE REGULATOR receiver
K5609_RS12430	COG2205	protein histidine kinase activity
K5609_RS12440	COG5001	Diguanylate cyclase
K5609_RS12440	COG5002	protein histidine kinase activity
K5609_RS12450	COG0626	cystathionine gamma-synthase activity
K5609_RS12455	COG0473	3-isopropylmalate dehydrogenase activity
K5609_RS12475	COG1842	Phage shock protein A
K5609_RS12480	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5609_RS12490	COG4168	peptide transport system, permease
K5609_RS12495	COG4171	peptide transport system, permease
K5609_RS12505	COG4172	Belongs to the ABC transporter superfamily
K5609_RS12515	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5609_RS12525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5609_RS12530	COG0776	regulation of translation
K5609_RS12535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K5609_RS12540	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K5609_RS12545	COG0217	transcriptional regulatory protein
K5609_RS12570	COG4106	trans-aconitate 2-methyltransferase activity
K5609_RS12600	COG0500	methyltransferase
K5609_RS12605	COG0189	ligase activity
K5609_RS12605	COG4067	protein conserved in archaea
K5609_RS12620	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K5609_RS12625	COG1286	toxin biosynthetic process
K5609_RS12630	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K5609_RS12635	COG0285	dihydrofolate synthase activity
K5609_RS12640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K5609_RS12645	COG0101	tRNA pseudouridine synthase activity
K5609_RS12655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K5609_RS12660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5609_RS12665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5609_RS12670	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K5609_RS12670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5609_RS12680	COG2201	protein-glutamate methylesterase activity
K5609_RS12685	COG3706	GGDEF domain
K5609_RS12700	COG3101	peptidyl-lysine hydroxylation
K5609_RS12705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5609_RS12710	COG2890	protein-(glutamine-N5) methyltransferase activity
K5609_RS12715	COG2840	Smr protein MutS2
K5609_RS12725	COG2062	phosphohistidine phosphatase, SixA
K5609_RS12745	COG0183	Belongs to the thiolase family
K5609_RS12750	COG0714	Associated with various cellular activities
K5609_RS12780	COG3691	Protein conserved in bacteria
K5609_RS12785	COG1595	DNA-templated transcription, initiation
K5609_RS12805	COG1435	thymidine kinase activity
K5609_RS12810	COG1757	Na H antiporter
K5609_RS12815	COG2916	Histone family protein nucleoid-structuring protein H-NS
K5609_RS12820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5609_RS12825	COG0602	queuosine metabolic process
K5609_RS12830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K5609_RS12845	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K5609_RS12850	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K5609_RS12855	COG0776	regulation of translation
K5609_RS12860	COG0539	negative regulation of cytoplasmic translation
K5609_RS12865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5609_RS12885	COG1086	Polysaccharide biosynthesis protein
K5609_RS12895	COG1083	cytidylyl-transferase
K5609_RS12960	COG2089	acid synthase
K5609_RS12995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K5609_RS13015	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5609_RS13015	COG3951	Flagellar rod assembly protein muramidase FlgJ
K5609_RS13020	COG1706	bacterial-type flagellum-dependent cell motility
K5609_RS13025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K5609_RS13035	COG4786	Flagellar basal body rod
K5609_RS13050	COG1558	bacterial-type flagellum-dependent cell motility
K5609_RS13055	COG1815	bacterial-type flagellum-dependent cell motility
K5609_RS13060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K5609_RS13065	COG0835	chemotaxis
K5609_RS13065	COG0784	Response regulator, receiver
K5609_RS13205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5609_RS13215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5609_RS13220	COG1022	Amp-dependent synthetase and ligase
K5609_RS13235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5609_RS13245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5609_RS13250	COG0438	transferase activity, transferring glycosyl groups
K5609_RS13255	COG0438	transferase activity, transferring glycosyl groups
K5609_RS13260	COG0438	transferase activity, transferring glycosyl groups
K5609_RS13270	COG0438	transferase activity, transferring glycosyl groups
K5609_RS13285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5609_RS13300	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5609_RS13320	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K5609_RS13325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K5609_RS13375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K5609_RS13380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5609_RS13380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5609_RS13385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5609_RS13390	COG1086	Polysaccharide biosynthesis protein
K5609_RS13395	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K5609_RS13400	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5609_RS13405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5609_RS13430	COG0529	Catalyzes the synthesis of activated sulfate
K5609_RS13435	COG0471	metal ion transport
K5609_RS13435	COG3273	potassium ion transport
K5609_RS13440	COG2895	sulfate adenylyltransferase (ATP) activity
K5609_RS13445	COG0175	sulfate reduction
K5609_RS13465	COG3088	subunit of a heme lyase
K5609_RS13465	COG4235	cytochrome complex assembly
K5609_RS13470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5609_RS13475	COG1138	Cytochrome C-type biogenesis protein
K5609_RS13480	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K5609_RS13485	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K5609_RS13490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K5609_RS13495	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K5609_RS13500	COG4133	protoheme IX ABC transporter activity
K5609_RS13510	COG0835	chemotaxis
K5609_RS13520	COG1192	Involved in chromosome partitioning
K5609_RS13525	COG1360	Flagellar Motor Protein
K5609_RS13530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K5609_RS13535	COG2201	protein-glutamate methylesterase activity
K5609_RS13540	COG0784	Response regulator, receiver
K5609_RS13540	COG0643	Histidine kinase
K5609_RS13540	COG2198	Histidine kinase
K5609_RS13545	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K5609_RS13580	COG1684	flagellar biosynthetic protein fliR
K5609_RS13585	COG1987	bacterial-type flagellum assembly
K5609_RS13635	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K5609_RS13640	COG1766	The M ring may be actively involved in energy transduction
K5609_RS13645	COG1677	Flagellar hook-basal body complex protein FliE
K5609_RS13650	COG5001	Diguanylate cyclase
K5609_RS13650	COG2203	Gaf domain
K5609_RS13650	COG3706	GGDEF domain
K5609_RS13650	COG4251	negative regulation of phosphorylation
K5609_RS13655	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K5609_RS13665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5609_RS13670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K5609_RS13680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5609_RS13690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5609_RS13695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5609_RS13700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K5609_RS13720	COG0436	Aminotransferase
K5609_RS13725	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K5609_RS13730	COG0517	IMP dehydrogenase activity
K5609_RS13750	COG0704	Plays a role in the regulation of phosphate uptake
K5609_RS13755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5609_RS13760	COG0581	inorganic phosphate transmembrane transporter activity
K5609_RS13775	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K5609_RS13780	COG1418	mRNA catabolic process
K5609_RS13790	COG3655	Transcriptional regulator
K5609_RS13815	COG3250	beta-galactosidase activity
K5609_RS13830	COG2837	iron assimilation
K5609_RS13850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K5609_RS13855	COG5002	protein histidine kinase activity
K5609_RS13860	COG0745	RESPONSE REGULATOR receiver
K5609_RS13865	COG3769	mannosylglycerate metabolic process
K5609_RS13870	COG1215	transferase activity, transferring glycosyl groups
K5609_RS13900	COG0366	Alpha amylase catalytic
K5609_RS13920	COG1733	regulation of RNA biosynthetic process
K5609_RS13935	COG2974	May be involved in recombination
K5609_RS13940	COG0826	peptidase U32
K5609_RS13945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5609_RS13960	COG0840	transmembrane signaling receptor activity
K5609_RS13965	COG1346	cytolysis
K5609_RS13970	COG1380	Effector of murein hydrolase LrgA
K5609_RS13975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5609_RS14020	COG2358	TRAP transporter, solute receptor (TAXI family
K5609_RS14030	COG3034	peptidoglycan biosynthetic process
K5609_RS14050	COG3154	lipid carrier protein
K5609_RS14055	COG0826	peptidase U32
K5609_RS14060	COG0826	peptidase U32
K5609_RS14070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K5609_RS14075	COG2912	Transglutaminase-like superfamily
K5609_RS14080	COG2890	protein-(glutamine-N5) methyltransferase activity
K5609_RS14085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5609_RS14090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K5609_RS14095	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K5609_RS14100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5609_RS14110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K5609_RS14115	COG0193	aminoacyl-tRNA hydrolase activity
K5609_RS14160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5609_RS14165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5609_RS14170	COG1702	phosphate starvation-inducible protein PhoH
K5609_RS14175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5609_RS14180	COG4535	Mg2 and Co2 transporter CorC
K5609_RS14185	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K5609_RS14190	COG2888	peptidyl-tyrosine sulfation
K5609_RS14195	COG0495	leucyl-tRNA aminoacylation
K5609_RS14205	COG1466	dna polymerase III delta subunit
K5609_RS14210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5609_RS14215	COG0799	negative regulation of ribosome biogenesis
K5609_RS14220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K5609_RS14225	COG0768	penicillin binding
K5609_RS14230	COG0772	Belongs to the SEDS family
K5609_RS14235	COG2951	lytic endotransglycosylase activity
K5609_RS14240	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K5609_RS14245	COG1686	Belongs to the peptidase S11 family
K5609_RS14250	COG2921	Belongs to the UPF0250 family
K5609_RS14255	COG0321	lipoyl(octanoyl) transferase activity
K5609_RS14260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K5609_RS14285	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K5609_RS14290	COG0583	DNA-binding transcription factor activity
K5609_RS14300	COG0840	transmembrane signaling receptor activity
K5609_RS14310	COG3284	Transcriptional regulator
K5609_RS14320	COG4221	oxidoreductase activity
K5609_RS14325	COG0583	DNA-binding transcription factor activity
K5609_RS14350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K5609_RS14355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K5609_RS14365	COG1073	alpha beta
K5609_RS14370	COG2252	PERMEase
K5609_RS14375	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5609_RS14380	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5609_RS14390	COG0346	lactoylglutathione lyase activity
K5609_RS14395	COG5001	Diguanylate cyclase
K5609_RS14400	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K5609_RS14405	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K5609_RS14410	COG1058	Belongs to the CinA family
K5609_RS14410	COG1546	Belongs to the CinA family
K5609_RS14415	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K5609_RS14420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5609_RS14425	COG1609	Transcriptional regulator
K5609_RS14430	COG0259	pyridoxamine-phosphate oxidase activity
K5609_RS14435	COG0741	lytic transglycosylase activity
K5609_RS14440	COG4172	Belongs to the ABC transporter superfamily
K5609_RS14445	COG4239	(ABC) transporter, permease
K5609_RS14450	COG4174	ABC transporter (Permease)
K5609_RS14455	COG4166	transmembrane transport
K5609_RS14465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K5609_RS14470	COG0077	Prephenate dehydratase
K5609_RS14470	COG1605	Chorismate mutase
K5609_RS14475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5609_RS14480	COG4137	Cytochrome C assembly protein
K5609_RS14485	COG4536	flavin adenine dinucleotide binding
K5609_RS14500	COG2918	glutathione biosynthetic process
K5609_RS14505	COG0612	Peptidase, M16
K5609_RS14510	COG1238	metal cluster binding
K5609_RS14515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5609_RS14525	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K5609_RS14530	COG0511	ligase activity, forming carbon-carbon bonds
K5609_RS14530	COG5016	pyruvate
K5609_RS14580	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K5609_RS14590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5609_RS14600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5609_RS14605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5609_RS14610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5609_RS14615	COG1388	LysM domain
K5609_RS14615	COG4942	peptidase
K5609_RS14620	COG1238	metal cluster binding
K5609_RS14625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K5609_RS14630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K5609_RS14635	COG0585	pseudouridine synthase activity
K5609_RS14640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K5609_RS14650	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K5609_RS14655	COG0148	phosphopyruvate hydratase activity
K5609_RS14660	COG0504	CTP synthase activity
K5609_RS14665	COG3956	TIGRFAM MazG family protein
K5609_RS14670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5609_RS14675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5609_RS14690	COG0736	holo-[acyl-carrier-protein] synthase activity
K5609_RS14695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K5609_RS14700	COG1381	Involved in DNA repair and RecF pathway recombination
K5609_RS14705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5609_RS14710	COG0571	ribonuclease III activity
K5609_RS14720	COG0481	GTPase activity
K5609_RS14725	COG3086	response to oxidative stress
K5609_RS14740	COG1595	DNA-templated transcription, initiation
K5609_RS14745	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K5609_RS14755	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K5609_RS14770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5609_RS14775	COG0581	inorganic phosphate transmembrane transporter activity
K5609_RS14780	COG0573	inorganic phosphate transmembrane transporter activity
K5609_RS14785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5609_RS14790	COG3108	Peptidase M15
K5609_RS14795	COG2989	Protein conserved in bacteria
K5609_RS14820	COG0655	NAD(P)H dehydrogenase (quinone) activity
K5609_RS14855	COG0039	L-malate dehydrogenase activity
K5609_RS14875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5609_RS14880	COG4232	protein-disulfide reductase activity
K5609_RS14895	COG0840	transmembrane signaling receptor activity
K5609_RS14910	COG0668	transmembrane transport
K5609_RS14915	COG0387	Pfam Sodium calcium exchanger
K5609_RS14920	COG0586	Pfam SNARE associated Golgi protein
K5609_RS14925	COG0583	DNA-binding transcription factor activity
K5609_RS14940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5609_RS14945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5609_RS14955	COG0598	Magnesium transport protein CorA
K5609_RS14980	COG2304	oxidoreductase activity
K5609_RS14995	COG1404	Belongs to the peptidase S8 family
K5609_RS15000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5609_RS15005	COG3547	Transposase (IS116 IS110 IS902 family)
K5609_RS15025	COG0625	glutathione transferase activity
K5609_RS15040	COG2133	pyrroloquinoline quinone binding
K5609_RS15055	COG3321	synthase
K5609_RS15055	COG1028	Short-chain dehydrogenase reductase Sdr
K5609_RS15055	COG0604	alcohol dehydrogenase
K5609_RS15095	COG2207	Transcriptional regulator
K5609_RS15115	COG1132	(ABC) transporter
K5609_RS15160	COG0045	succinate-CoA ligase (ADP-forming) activity
K5609_RS15160	COG1042	CoA-binding domain protein
K5609_RS15160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5609_RS15175	COG0301	tRNA thio-modification
K5609_RS15175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5609_RS15180	COG1360	Flagellar Motor Protein
K5609_RS15185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K5609_RS15195	COG0142	geranyltranstransferase activity
K5609_RS15200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5609_RS15205	COG4166	transmembrane transport
K5609_RS15210	COG4608	Belongs to the ABC transporter superfamily
K5609_RS15215	COG0444	Belongs to the ABC transporter superfamily
K5609_RS15220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5609_RS15225	COG0601	transmembrane transport
K5609_RS15230	COG0747	negative chemotaxis
K5609_RS15235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K5609_RS15240	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K5609_RS15245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5609_RS15250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K5609_RS15265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5609_RS15265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5609_RS15270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5609_RS15275	COG0693	protein deglycase activity
K5609_RS15300	COG1388	LysM domain
K5609_RS15300	COG1376	ErfK ybiS ycfS ynhG family protein
K5609_RS15305	COG0488	(ABC) transporter
K5609_RS15325	COG3040	lipid binding
K5609_RS15335	COG0579	oxidoreductase
K5609_RS15340	COG0678	peroxiredoxin activity
K5609_RS15365	COG1595	DNA-templated transcription, initiation
K5609_RS15375	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K5609_RS15385	COG2996	Protein conserved in bacteria
K5609_RS15400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5609_RS15415	COG3916	Acyl-homoserine-lactone synthase
K5609_RS15425	COG2197	response regulator
K5609_RS15430	COG2860	membrane
K5609_RS15435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5609_RS15440	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K5609_RS15445	COG2816	NAD+ diphosphatase activity
K5609_RS15455	COG3005	denitrification pathway
K5609_RS15470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K5609_RS15475	COG2199	diguanylate cyclase activity
K5609_RS15475	COG2200	EAL domain
K5609_RS15480	COG0243	molybdopterin cofactor binding
K5609_RS15490	COG0328	RNA-DNA hybrid ribonuclease activity
K5609_RS15505	COG0640	Transcriptional regulator
K5609_RS15515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K5609_RS15540	COG0513	Belongs to the DEAD box helicase family
K5609_RS15550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5609_RS15565	COG2814	Major facilitator Superfamily
K5609_RS15570	COG0583	DNA-binding transcription factor activity
K5609_RS15575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5609_RS15590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5609_RS15615	COG1280	lysine exporter protein (LysE YggA)
K5609_RS15620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5609_RS15625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K5609_RS15645	COG0702	epimerase
K5609_RS15655	COG4143	(ABC) transporter
K5609_RS15665	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K5609_RS15690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5609_RS15695	COG2813	Specifically methylates the guanine in position
K5609_RS15700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K5609_RS15705	COG0297	glycogen (starch) synthase activity
K5609_RS15720	COG0697	spore germination
K5609_RS15745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K5609_RS15755	COG2154	pterin-4-alpha-carbinolamine dehydratase
K5609_RS15765	COG2207	Transcriptional regulator
K5609_RS15770	COG1573	uracil-dna glycosylase
K5609_RS15775	COG0667	Aldo Keto reductase
K5609_RS15790	COG2193	ferroxidase activity
K5609_RS15800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5609_RS15805	COG3135	benzoate transporter
K5609_RS15810	COG1396	sequence-specific DNA binding
K5609_RS15820	COG0735	belongs to the Fur family
K5609_RS15825	COG0739	heme binding
K5609_RS15840	COG0129	dihydroxy-acid dehydratase activity
K5609_RS15845	COG3265	gluconokinase activity
K5609_RS15850	COG3459	Glycosyltransferase 36 associated
K5609_RS15855	COG1609	Transcriptional regulator
K5609_RS15865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5609_RS15895	COG0708	Exodeoxyribonuclease III
K5609_RS15905	COG0754	glutathionylspermidine amidase activity
K5609_RS15910	COG5463	Belongs to the UPF0441 family
K5609_RS15915	COG3766	membrane
K5609_RS15930	COG1842	Phage shock protein A
K5609_RS15945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5609_RS15960	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K5609_RS16020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5609_RS16050	COG0748	coenzyme F420 binding
K5609_RS16055	COG3721	Heme iron utilization protein
K5609_RS16060	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K5609_RS16065	COG0811	peptide transport
K5609_RS16070	COG0848	biopolymer transport protein
K5609_RS16080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5609_RS16100	COG2267	carboxylic ester hydrolase activity
K5609_RS16115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K5609_RS16125	COG0840	transmembrane signaling receptor activity
K5609_RS16145	COG3487	Iron-regulated protein
K5609_RS16155	COG0251	oxidation-reduction process
K5609_RS16170	COG0840	transmembrane signaling receptor activity
K5609_RS16190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K5609_RS16230	COG3386	PFAM SMP-30 Gluconolaconase
K5609_RS16255	COG0583	DNA-binding transcription factor activity
K5609_RS16265	COG0667	Aldo Keto reductase
K5609_RS16270	COG5002	protein histidine kinase activity
K5609_RS16270	COG5001	Diguanylate cyclase
K5609_RS16295	COG1183	phosphatidylcholine synthase activity
K5609_RS16305	COG0542	response to heat
K5609_RS16320	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5609_RS16365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K5609_RS16370	COG1047	Peptidyl-prolyl cis-trans
K5609_RS16380	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5609_RS16385	COG0196	riboflavin kinase activity
K5609_RS16390	COG0728	peptidoglycan biosynthetic process
K5609_RS16395	COG0268	Binds directly to 16S ribosomal RNA
K5609_RS16400	COG0640	Transcriptional regulator
K5609_RS16410	COG0583	DNA-binding transcription factor activity
K5609_RS16415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K5609_RS16420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K5609_RS16425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5609_RS16435	COG0494	nUDIX hydrolase
K5609_RS16440	COG3066	DNA modification
K5609_RS16450	COG0335	large ribosomal subunit rRNA binding
K5609_RS16455	COG0336	Belongs to the RNA methyltransferase TrmD family
K5609_RS16460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5609_RS16465	COG0228	four-way junction DNA binding
K5609_RS16470	COG1011	Hydrolase
K5609_RS16475	COG3036	rescue of stalled ribosome
K5609_RS16515	COG2205	protein histidine kinase activity
K5609_RS16515	COG0784	Response regulator, receiver
K5609_RS16545	COG0395	ABC-type sugar transport system, permease component
K5609_RS16555	COG3842	ATPase activity
K5609_RS16560	COG3842	ATPase activity
K5609_RS16565	COG3284	Transcriptional regulator
K5609_RS16580	COG1028	Short-chain dehydrogenase reductase Sdr
K5609_RS16595	COG0840	transmembrane signaling receptor activity
K5609_RS16600	COG3118	belongs to the thioredoxin family
K5609_RS16605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K5609_RS16610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5609_RS16615	COG4974	Belongs to the 'phage' integrase family
K5609_RS16620	COG0716	FMN binding
K5609_RS16630	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K5609_RS16635	COG0513	Belongs to the DEAD box helicase family
K5609_RS16640	COG2885	chlorophyll binding
K5609_RS16640	COG3047	cAMP biosynthetic process
K5609_RS16650	COG3022	response to hydroperoxide
K5609_RS16665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K5609_RS16670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5609_RS16675	COG0762	integral membrane protein
K5609_RS16690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K5609_RS16695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5609_RS16700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5609_RS16705	COG3813	Protein conserved in bacteria
K5609_RS16725	COG1522	sequence-specific DNA binding
K5609_RS16730	COG1194	a g-specific adenine glycosylase
K5609_RS16735	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K5609_RS16775	COG0546	phosphoglycolate phosphatase activity
K5609_RS16795	COG0583	DNA-binding transcription factor activity
K5609_RS16835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5609_RS16840	COG3314	Sporulation integral membrane protein YlbJ
K5609_RS16865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K5609_RS16875	COG0560	Phosphoserine phosphatase
K5609_RS16885	COG0813	purine-nucleoside phosphorylase activity
K5609_RS16890	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K5609_RS16895	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K5609_RS16900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K5609_RS16905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K5609_RS16920	COG0084	hydrolase, TatD family'
K5609_RS16930	COG1744	ABC transporter substrate-binding protein PnrA-like
K5609_RS16935	COG3845	ABC transporter
K5609_RS16940	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5609_RS16945	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5609_RS16955	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K5609_RS16980	COG0628	permease
K5609_RS16985	COG1501	Belongs to the glycosyl hydrolase 31 family
K5609_RS16990	COG0583	DNA-binding transcription factor activity
K5609_RS17015	COG2382	esterase
K5609_RS17015	COG3507	Belongs to the glycosyl hydrolase 43 family
K5609_RS17015	COG3693	PFAM glycoside hydrolase, family 10
K5609_RS17040	COG1187	pseudouridine synthase activity
K5609_RS17080	COG0778	Nitroreductase
K5609_RS17095	COG0167	dihydroorotate dehydrogenase activity
K5609_RS17095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K5609_RS17100	COG0493	'glutamate synthase
K5609_RS17105	COG1309	transcriptional regulator
K5609_RS17125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5609_RS17130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5609_RS17135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5609_RS17165	COG2731	YhcH YjgK YiaL family protein
K5609_RS17170	COG0840	transmembrane signaling receptor activity
K5609_RS17195	COG4580	involved in the transport of maltose and maltodextrins
K5609_RS17210	COG3250	beta-galactosidase activity
K5609_RS17215	COG1609	Transcriptional regulator
K5609_RS17225	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K5609_RS17230	COG1063	alcohol dehydrogenase
K5609_RS17235	COG0246	Mannitol dehydrogenase
K5609_RS17240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5609_RS17245	COG0800	Aldolase
K5609_RS17250	COG4948	Mandelate Racemase Muconate Lactonizing
K5609_RS17255	COG2814	Major facilitator Superfamily
K5609_RS17260	COG2186	Transcriptional regulator
K5609_RS17265	COG1012	belongs to the aldehyde dehydrogenase family
K5609_RS17275	COG0582	viral genome integration into host DNA
K5609_RS17300	COG0795	lipopolysaccharide-transporting ATPase activity
K5609_RS17305	COG0795	lipopolysaccharide-transporting ATPase activity
K5609_RS17310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K5609_RS17315	COG2927	DNA polymerase III (CHI subunit)
K5609_RS17320	COG0525	valine-tRNA ligase activity
K5609_RS17335	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
K5609_RS17340	COG0204	Acyl-transferase
K5609_RS17350	COG5002	protein histidine kinase activity
K5609_RS17350	COG5001	Diguanylate cyclase
K5609_RS17360	COG3150	esterase
K5609_RS17370	COG3151	Protein conserved in bacteria
K5609_RS17375	COG0494	nUDIX hydrolase
K5609_RS17380	COG1538	Outer membrane efflux protein
K5609_RS17385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5609_RS17385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K5609_RS17390	COG1560	Kdo2-lipid A biosynthetic process
K5609_RS17395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K5609_RS17400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5609_RS17410	COG3025	triphosphatase activity
K5609_RS17415	COG1392	Phosphate transport regulator
K5609_RS17420	COG0306	phosphate transporter
K5609_RS17435	COG3409	Peptidoglycan-binding domain 1 protein
K5609_RS17435	COG3267	Type II secretory pathway component ExeA
K5609_RS17440	COG0617	tRNA 3'-terminal CCA addition
K5609_RS17445	COG1968	undecaprenyl-diphosphatase activity
K5609_RS17455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K5609_RS17460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K5609_RS17465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5609_RS17475	COG1610	YqeY-like protein
K5609_RS17480	COG0358	DNA primase activity
K5609_RS17535	COG1278	Cold shock
K5609_RS17560	COG0582	viral genome integration into host DNA
K5609_RS17570	COG0840	transmembrane signaling receptor activity
K5609_RS17615	COG4166	transmembrane transport
K5609_RS17630	COG0444	Belongs to the ABC transporter superfamily
K5609_RS17635	COG4608	Belongs to the ABC transporter superfamily
K5609_RS17650	COG1609	Transcriptional regulator
K5609_RS17670	COG0697	spore germination
K5609_RS17700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5609_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
K5609_RS17710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5609_RS17740	COG2986	histidine ammonia-lyase
K5609_RS17750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5609_RS17765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5609_RS17770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5609_RS17820	COG2942	2-epimerase
K5609_RS17825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5609_RS17840	COG2116	formate transmembrane transporter activity
K5609_RS17845	COG0583	DNA-binding transcription factor activity
K5609_RS17850	COG0297	glycogen (starch) synthase activity
K5609_RS17870	COG3038	cytochrome b561
K5609_RS17895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K5609_RS17935	COG1584	GPR1 FUN34 yaaH family protein
K5609_RS17960	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K5609_RS17975	COG2431	L-lysine efflux transmembrane transporter activity
K5609_RS17980	COG0784	Response regulator, receiver
K5609_RS17980	COG2198	Histidine kinase
K5609_RS17980	COG5002	protein histidine kinase activity
K5609_RS17985	COG1469	GTP cyclohydrolase I activity
K5609_RS17990	COG2203	Gaf domain
K5609_RS17990	COG4251	negative regulation of phosphorylation
K5609_RS17990	COG5001	Diguanylate cyclase
K5609_RS17990	COG3706	GGDEF domain
K5609_RS17995	COG1242	4 iron, 4 sulfur cluster binding
K5609_RS18005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K5609_RS18015	COG1012	belongs to the aldehyde dehydrogenase family
K5609_RS18030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5609_RS18050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K5609_RS18075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K5609_RS18085	COG2832	Protein of unknown function (DUF454)
K5609_RS18115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5609_RS18145	COG1643	Atp-dependent helicase
K5609_RS18155	COG1489	DNA binding
K5609_RS18160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K5609_RS18165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5609_RS18175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K5609_RS18180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K5609_RS18185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K5609_RS18190	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K5609_RS18215	COG0842	Transport permease protein
K5609_RS18220	COG1131	(ABC) transporter
K5609_RS18235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5609_RS18255	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K5609_RS18265	COG0175	sulfate reduction
K5609_RS18270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K5609_RS18275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K5609_RS18290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K5609_RS18295	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K5609_RS18305	COG1607	acyl-coa hydrolase
K5609_RS18310	COG2204	response regulator
K5609_RS18320	COG3267	Type II secretory pathway component ExeA
K5609_RS18320	COG3409	Peptidoglycan-binding domain 1 protein
K5609_RS18330	COG0489	protein tyrosine kinase activity
K5609_RS18345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5609_RS18355	COG0438	transferase activity, transferring glycosyl groups
K5609_RS18365	COG0726	polysaccharide deacetylase
K5609_RS18380	COG1045	serine acetyltransferase
K5609_RS18410	COG1216	Glycosyl transferase, family 2
K5609_RS18415	COG1216	Glycosyl transferase, family 2
K5609_RS18440	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K5609_RS18475	COG0629	single-stranded DNA binding
K5609_RS18480	COG2814	Major facilitator Superfamily
K5609_RS18485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5609_RS18520	COG0791	NLP P60 protein
K5609_RS18525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K5609_RS18530	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K5609_RS18555	COG0429	hydrolase of the alpha beta-hydrolase fold
K5609_RS18560	COG3089	Belongs to the UPF0270 family
K5609_RS18565	COG3954	Phosphoribulokinase
K5609_RS18570	COG1765	OsmC-like protein
K5609_RS18585	COG1012	belongs to the aldehyde dehydrogenase family
K5609_RS18595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K5609_RS18620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5609_RS18630	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K5609_RS18640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K5609_RS18645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5609_RS18675	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K5609_RS18690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5609_RS18695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5609_RS18700	COG0049	tRNA binding
K5609_RS18705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5609_RS18715	COG2923	Belongs to the DsrF TusC family
K5609_RS18720	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K5609_RS18725	COG0251	oxidation-reduction process
K5609_RS18730	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5609_RS18735	COG0085	RNA polymerase activity
K5609_RS18740	COG0222	ribosome binding
K5609_RS18745	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5609_RS18755	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5609_RS18760	COG0250	Participates in transcription elongation, termination and antitermination
K5609_RS18765	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5609_RS18775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5609_RS18805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5609_RS18810	COG1072	(Pantothenic acid kinase))
K5609_RS18815	COG0489	protein tyrosine kinase activity
K5609_RS18815	COG3206	protein involved in exopolysaccharide biosynthesis
K5609_RS18820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5609_RS18825	COG0255	Belongs to the universal ribosomal protein uL29 family
K5609_RS18830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5609_RS18835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5609_RS18840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5609_RS18845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5609_RS18850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5609_RS18855	COG0089	rRNA binding
K5609_RS18860	COG0088	Forms part of the polypeptide exit tunnel
K5609_RS18865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5609_RS18870	COG0051	transcription antitermination factor activity, RNA binding
K5609_RS18885	COG2315	Protein conserved in bacteria
K5609_RS18900	COG0137	argininosuccinate synthase activity
K5609_RS18910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K5609_RS18920	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K5609_RS18935	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K5609_RS18940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5609_RS18945	COG1609	Transcriptional regulator
K5609_RS18950	COG5297	Belongs to the glycosyl hydrolase family 6
K5609_RS18950	COG2273	Hydrolase Family 16
K5609_RS18955	COG2183	response to ionizing radiation
K5609_RS18970	COG0596	Alpha beta hydrolase
K5609_RS18975	COG1040	competence protein
K5609_RS18980	COG0316	Belongs to the HesB IscA family
K5609_RS18980	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K5609_RS18990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5609_RS18995	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K5609_RS19000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5609_RS19005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K5609_RS19070	COG1494	fructose-1,6-bisphosphatase
K5609_RS19080	COG0686	Belongs to the AlaDH PNT family
K5609_RS19095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K5609_RS19095	COG1648	precorrin-2 dehydrogenase activity
K5609_RS19100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K5609_RS19100	COG2146	nitrite reductase [NAD(P)H] activity
K5609_RS19110	COG2223	nitrite transmembrane transporter activity
K5609_RS19115	COG0515	serine threonine protein kinase
K5609_RS19115	COG2815	serine threonine protein kinase
K5609_RS19155	COG2177	Part of the ABC transporter FtsEX involved in
K5609_RS19160	COG2884	Cell division ATP-binding protein ftsE
K5609_RS19165	COG0552	protein localization to endoplasmic reticulum
K5609_RS19170	COG0742	ribosomal rna small subunit methyltransferase
K5609_RS19185	COG2095	MarC family integral membrane protein
K5609_RS19220	COG0004	ammonium transporteR
K5609_RS19225	COG0248	Ppx GppA phosphatase
K5609_RS19250	COG3437	response regulator, receiver
K5609_RS19250	COG2770	Histidine kinase
K5609_RS19255	COG0494	nUDIX hydrolase
K5609_RS19275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5609_RS19280	COG1074	ATP-dependent DNA helicase activity
K5609_RS19285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K5609_RS19295	COG0606	chelatase, subunit chli
K5609_RS19300	COG0517	IMP dehydrogenase activity
K5609_RS19300	COG0516	GMP reductase activity
K5609_RS19305	COG0110	maltose O-acetyltransferase activity
K5609_RS19320	COG3978	acetolactate synthase activity
K5609_RS19325	COG0129	dihydroxy-acid dehydratase activity
K5609_RS19345	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K5609_RS19350	COG0366	Alpha amylase catalytic
K5609_RS19370	COG0454	-acetyltransferase
K5609_RS19400	COG1472	Belongs to the glycosyl hydrolase 3 family
K5609_RS19410	COG4682	membrane
K5609_RS19440	COG5002	protein histidine kinase activity
K5609_RS19440	COG3447	MASE1 domain protein
K5609_RS19440	COG5001	Diguanylate cyclase
K5609_RS19450	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K5609_RS19465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K5609_RS19475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5609_RS19480	COG1929	Belongs to the glycerate kinase type-1 family
K5609_RS19490	COG1279	arginine transmembrane transporter activity
K5609_RS19505	COG0697	spore germination
K5609_RS19510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K5609_RS19515	COG1609	Transcriptional regulator
K5609_RS19535	COG0395	ABC-type sugar transport system, permease component
K5609_RS19550	COG3842	ATPase activity
K5609_RS19585	COG2960	long-chain fatty acid transporting porin activity
K5609_RS19605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K5609_RS19615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5609_RS19625	COG0840	transmembrane signaling receptor activity
K5609_RS19650	COG4335	DNA alkylation repair
K5609_RS19675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K5609_RS19685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5609_RS19690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5609_RS19695	COG1309	transcriptional regulator
K5609_RS19700	COG0210	DNA helicase
K5609_RS19710	COG0366	Alpha amylase catalytic
K5609_RS19710	COG1874	Beta-galactosidase
K5609_RS19715	COG1523	belongs to the glycosyl hydrolase 13 family
K5609_RS19725	COG1846	Transcriptional regulator
K5609_RS19725	COG1940	carbohydrate kinase activity
K5609_RS19735	COG2391	methyltransferase activity
K5609_RS19755	COG0366	Alpha amylase catalytic
K5609_RS19770	COG1917	Cupin 2, conserved barrel domain protein
K5609_RS19770	COG4977	sequence-specific DNA binding
K5609_RS19785	COG0443	Heat shock 70 kDa protein
K5609_RS19800	COG1132	(ABC) transporter
K5609_RS19830	COG0189	ligase activity
K5609_RS19845	COG0189	ligase activity
K5609_RS19845	COG4067	protein conserved in archaea
K5609_RS19850	COG2239	Acts as a magnesium transporter
K5609_RS19855	COG0598	Magnesium transport protein CorA
K5609_RS19875	COG0702	epimerase
K5609_RS19885	COG3226	Transcriptional regulator
K5609_RS19890	COG3111	PFAM Bacterial OB fold (BOF) protein
K5609_RS19900	COG2988	succinylglutamate desuccinylase activity
K5609_RS19905	COG1609	Transcriptional regulator
K5609_RS19905	COG2207	Transcriptional regulator
K5609_RS19910	COG1070	Carbohydrate kinase
K5609_RS19915	COG1609	Transcriptional regulator
K5609_RS19915	COG2207	Transcriptional regulator
K5609_RS19925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K5609_RS19935	COG2115	Belongs to the xylose isomerase family
K5609_RS19945	COG1793	dna ligase
K5609_RS19975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K5609_RS19980	COG0352	thiamine-phosphate diphosphorylase activity
K5609_RS19985	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K5609_RS20000	COG1575	Belongs to the MenA family. Type 1 subfamily
K5609_RS20005	COG1169	isochorismate synthase
K5609_RS20010	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K5609_RS20020	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K5609_RS20030	COG4213	ABC transporter substrate-binding protein
K5609_RS20035	COG1129	ABC transporter
K5609_RS20040	COG4214	carbohydrate transport
K5609_RS20055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5609_RS20070	COG1119	ATPase activity
K5609_RS20115	COG2203	Gaf domain
K5609_RS20115	COG4251	negative regulation of phosphorylation
K5609_RS20115	COG5001	Diguanylate cyclase
K5609_RS20115	COG3706	GGDEF domain
K5609_RS20125	COG2814	Major facilitator Superfamily
K5609_RS20135	COG3263	regulation of cellular component size
K5609_RS20140	COG0737	Belongs to the 5'-nucleotidase family
K5609_RS20150	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K5609_RS20160	COG1272	protein, Hemolysin III
K5609_RS20225	COG0714	Associated with various cellular activities
K5609_RS20255	COG0411	ABC transporter
K5609_RS20275	COG0829	nickel cation binding
K5609_RS20280	COG0831	urea catabolic process
K5609_RS20285	COG0832	Belongs to the urease beta subunit family
K5609_RS20290	COG0804	urea catabolic process
K5609_RS20300	COG0830	nickel cation binding
K5609_RS20305	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K5609_RS20315	COG0318	PFAM AMP-dependent synthetase and ligase
K5609_RS20345	COG4459	periplasmic nitrate reductase
K5609_RS20350	COG3005	denitrification pathway
K5609_RS20355	COG0243	molybdopterin cofactor binding
K5609_RS20365	COG0281	malic enzyme
K5609_RS20380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K5609_RS20415	COG1404	Belongs to the peptidase S8 family
K5609_RS20430	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K5609_RS20455	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K5609_RS20465	COG2153	protein acetylation
K5609_RS20470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5609_RS20475	COG3085	chromosome segregation
K5609_RS20480	COG0408	coproporphyrinogen oxidase activity
K5609_RS20490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5609_RS20495	COG1121	(ABC) transporter
K5609_RS20500	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K5609_RS20505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5609_RS20515	COG3078	GTPase activator activity
K5609_RS20530	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K5609_RS20540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5609_RS20540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5609_RS20550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K5609_RS20555	COG0514	ATP-dependent DNA helicase (RecQ)
K5609_RS20560	COG2050	protein possibly involved in aromatic compounds catabolism
K5609_RS20570	COG2962	Rard protein
K5609_RS20575	COG0210	DNA helicase
K5609_RS20580	COG1011	Hydrolase
K5609_RS20595	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K5609_RS20600	COG0019	diaminopimelate decarboxylase activity
K5609_RS20615	COG3072	Adenylate cyclase
K5609_RS20620	COG0181	hydroxymethylbilane synthase activity
K5609_RS20635	COG3071	HemY protein
K5609_RS20650	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K5609_RS20665	COG3118	belongs to the thioredoxin family
K5609_RS20670	COG0513	Belongs to the DEAD box helicase family
K5609_RS20675	COG0248	Ppx GppA phosphatase
K5609_RS20685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5609_RS20690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5609_RS20695	COG3706	GGDEF domain
K5609_RS20720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5609_RS20725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K5609_RS20745	COG0577	efflux transmembrane transporter activity
K5609_RS20745	COG1136	(ABC) transporter
K5609_RS20775	COG0784	Response regulator, receiver
K5609_RS20775	COG0835	chemotaxis
K5609_RS20780	COG0583	DNA-binding transcription factor activity
K5609_RS20790	COG2130	NADP-dependent
K5609_RS20800	COG3842	ATPase activity
K5609_RS20810	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5609_RS20815	COG1177	transmembrane transport
K5609_RS20820	COG0678	peroxiredoxin activity
K5609_RS20820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5609_RS20825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5609_RS20830	COG5001	Diguanylate cyclase
K5609_RS20830	COG5002	protein histidine kinase activity
K5609_RS20835	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5609_RS20840	COG2153	protein acetylation
K5609_RS20845	COG0742	ribosomal rna small subunit methyltransferase
K5609_RS20850	COG5002	protein histidine kinase activity
K5609_RS20850	COG5001	Diguanylate cyclase
K5609_RS20855	COG0726	polysaccharide deacetylase
K5609_RS20860	COG1216	Glycosyl transferase, family 2
K5609_RS20870	COG4641	Protein conserved in bacteria
K5609_RS20870	COG0438	transferase activity, transferring glycosyl groups
K5609_RS20885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5609_RS20895	COG1063	alcohol dehydrogenase
K5609_RS20905	COG1309	transcriptional regulator
K5609_RS20910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5609_RS20915	COG0859	PFAM glycosyl transferase family 9
K5609_RS20920	COG0463	Glycosyl transferase, family 2
K5609_RS20935	COG1519	Transferase
K5609_RS20940	COG3642	lipopolysaccharide core region biosynthetic process
K5609_RS20945	COG0859	PFAM glycosyl transferase family 9
K5609_RS20950	COG0463	Glycosyl transferase, family 2
K5609_RS20960	COG0859	PFAM glycosyl transferase family 9
K5609_RS20965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5609_RS20970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5609_RS20980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5609_RS20985	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5609_RS20990	COG2003	Belongs to the UPF0758 family
K5609_RS20995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5609_RS21000	COG0756	dUTP diphosphatase activity
K5609_RS21005	COG1309	transcriptional regulator
K5609_RS21010	COG0668	transmembrane transport
K5609_RS21030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K5609_RS21035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5609_RS21040	COG1561	YicC-like family, N-terminal region
K5609_RS21055	COG2356	endonuclease I
K5609_RS21070	COG0668	transmembrane transport
K5609_RS21090	COG0673	inositol 2-dehydrogenase activity
K5609_RS21120	COG3395	kinase activity
K5609_RS21125	COG0235	Class ii aldolase
K5609_RS21135	COG3214	Protein conserved in bacteria
K5609_RS21150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K5609_RS21155	COG1349	DNA-binding transcription factor activity
K5609_RS21190	COG4807	Protein conserved in bacteria
K5609_RS21205	COG0435	Glutathione S-transferase
K5609_RS21210	COG1741	Belongs to the pirin family
K5609_RS21215	COG2259	Doxx family
K5609_RS21220	COG0583	DNA-binding transcription factor activity
K5609_RS21225	COG0330	HflC and HflK could
K5609_RS21240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5609_RS21260	COG0194	GDP metabolic process
K5609_RS21265	COG1758	RNA polymerase activity
K5609_RS21270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5609_RS21275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5609_RS21280	COG0840	transmembrane signaling receptor activity
K5609_RS21295	COG0204	Acyl-transferase
K5609_RS21310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5609_RS21320	COG2954	triphosphatase activity
K5609_RS21325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K5609_RS21340	COG3084	Protein conserved in bacteria
K5609_RS21345	COG5001	Diguanylate cyclase
K5609_RS21345	COG2203	Gaf domain
K5609_RS21345	COG3706	GGDEF domain
K5609_RS21345	COG4251	negative regulation of phosphorylation
K5609_RS21355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5609_RS21360	COG0417	DNA replication proofreading
K5609_RS21385	COG0534	Mate efflux family protein
K5609_RS21390	COG2860	membrane
K5609_RS21395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5609_RS21400	COG0469	pyruvate kinase activity
K5609_RS21410	COG0668	transmembrane transport
K5609_RS21420	COG0133	tryptophan synthase activity
K5609_RS21425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K5609_RS21430	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K5609_RS21435	COG0714	Associated with various cellular activities
K5609_RS21440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5609_RS21445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5609_RS21450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5609_RS21455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5609_RS21460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5609_RS21465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5609_RS21475	COG0356	it plays a direct role in the translocation of protons across the membrane
K5609_RS21485	COG1475	DNA binding
K5609_RS21490	COG1192	Involved in chromosome partitioning
K5609_RS21495	COG0357	Ribosomal RNA small subunit methyltransferase G
K5609_RS21505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K5609_RS21520	COG1294	oxidase, subunit
K5609_RS21525	COG1271	oxidase subunit
K5609_RS21535	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K5609_RS21550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5609_RS21555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5609_RS21590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5609_RS21650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K5609_RS21655	COG0706	membrane insertase activity
K5609_RS21660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5609_RS21665	COG0594	ribonuclease P activity
K5609_RS21675	COG1126	abc transporter atp-binding protein
K5609_RS21690	COG0671	phosphoesterase, PA-phosphatase related
K5609_RS21715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5609_RS21760	COG3706	GGDEF domain
K5609_RS21765	COG2186	Transcriptional regulator
K5609_RS21775	COG0742	ribosomal rna small subunit methyltransferase