locus-tag	class	description
K5620_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5620_RS00020	COG0187	DNA topoisomerase II activity
K5620_RS00030	COG3977	Valine--pyruvate aminotransferase
K5620_RS00035	COG0366	Alpha amylase catalytic
K5620_RS00045	COG0751	glycine-tRNA ligase activity
K5620_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
K5620_RS00055	COG0425	Belongs to the sulfur carrier protein TusA family
K5620_RS00060	COG3842	ATPase activity
K5620_RS00070	COG1175	transmembrane transport
K5620_RS00075	COG1653	transport
K5620_RS00090	COG0183	Belongs to the thiolase family
K5620_RS00095	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5620_RS00095	COG1024	Enoyl-CoA hydratase
K5620_RS00100	COG0006	proline dipeptidase activity
K5620_RS00105	COG1739	Uncharacterized protein family UPF0029
K5620_RS00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5620_RS00150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5620_RS00215	COG0583	DNA-binding transcription factor activity
K5620_RS00230	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K5620_RS00255	COG0673	inositol 2-dehydrogenase activity
K5620_RS00265	COG1309	transcriptional regulator
K5620_RS00275	COG3706	GGDEF domain
K5620_RS00295	COG2205	protein histidine kinase activity
K5620_RS00305	COG2204	response regulator
K5620_RS00310	COG1301	dicarboxylic acid transport
K5620_RS00330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5620_RS00350	COG2828	Protein conserved in bacteria
K5620_RS00355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K5620_RS00360	COG0372	Belongs to the citrate synthase family
K5620_RS00365	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K5620_RS00370	COG1802	Transcriptional regulator
K5620_RS00390	COG2226	methyltransferase
K5620_RS00400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K5620_RS00405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5620_RS00410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5620_RS00415	COG0805	protein transport
K5620_RS00435	COG1785	Belongs to the alkaline phosphatase family
K5620_RS00445	COG1785	Belongs to the alkaline phosphatase family
K5620_RS00470	COG1764	response to oxidative stress
K5620_RS00475	COG1846	Transcriptional regulator
K5620_RS00485	COG2873	o-acetylhomoserine
K5620_RS00500	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K5620_RS00515	COG0745	RESPONSE REGULATOR receiver
K5620_RS00535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5620_RS00545	COG3152	Membrane
K5620_RS00550	COG1451	nucleotide metabolic process
K5620_RS00560	COG0531	amino acid
K5620_RS00570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K5620_RS00580	COG2116	formate transmembrane transporter activity
K5620_RS00585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K5620_RS00585	COG1648	precorrin-2 dehydrogenase activity
K5620_RS00605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K5620_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
K5620_RS00615	COG0302	gtp cyclohydrolase
K5620_RS00620	COG0513	Belongs to the DEAD box helicase family
K5620_RS00640	COG1671	Belongs to the UPF0178 family
K5620_RS00660	COG1846	Transcriptional regulator
K5620_RS00675	COG3448	diguanylate cyclase activity
K5620_RS00675	COG4175	Glycine betaine
K5620_RS00710	COG1794	racemase activity, acting on amino acids and derivatives
K5620_RS00715	COG1278	Cold shock
K5620_RS00750	COG0513	Belongs to the DEAD box helicase family
K5620_RS00770	COG2815	serine threonine protein kinase
K5620_RS00770	COG0515	serine threonine protein kinase
K5620_RS00805	COG0631	protein serine/threonine phosphatase activity
K5620_RS00920	COG2081	HI0933 family
K5620_RS00930	COG0561	phosphatase activity
K5620_RS00935	COG2267	carboxylic ester hydrolase activity
K5620_RS00965	COG3784	Protein of unknown function (DUF1318)
K5620_RS00995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5620_RS01000	COG0569	domain protein
K5620_RS01005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5620_RS01005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5620_RS01025	COG0758	DNA mediated transformation
K5620_RS01030	COG2922	Belongs to the Smg family
K5620_RS01035	COG0551	DNA topoisomerase type I activity
K5620_RS01040	COG2204	response regulator
K5620_RS01045	COG3852	Histidine kinase
K5620_RS01055	COG0174	glutamine synthetase
K5620_RS01060	COG1217	gtp-binding protein TYPA
K5620_RS01075	COG0659	secondary active sulfate transmembrane transporter activity
K5620_RS01080	COG1295	ribonuclease BN
K5620_RS01090	COG1609	Transcriptional regulator
K5620_RS01095	COG2723	6-phospho-beta-galactosidase activity
K5620_RS01100	COG3842	ATPase activity
K5620_RS01105	COG3459	Glycosyltransferase 36 associated
K5620_RS01115	COG4580	involved in the transport of maltose and maltodextrins
K5620_RS01135	COG0456	acetyltransferase
K5620_RS01140	COG0583	DNA-binding transcription factor activity
K5620_RS01150	COG2076	Multidrug Resistance protein
K5620_RS01155	COG2076	Multidrug Resistance protein
K5620_RS01160	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K5620_RS01165	COG0726	polysaccharide deacetylase
K5620_RS01170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5620_RS01170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5620_RS01175	COG0463	Glycosyl transferase, family 2
K5620_RS01180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5620_RS01190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5620_RS01195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5620_RS01200	COG1349	DNA-binding transcription factor activity
K5620_RS01205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5620_RS01215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5620_RS01225	COG3122	Protein conserved in bacteria
K5620_RS01235	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K5620_RS01240	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K5620_RS01250	COG0071	Belongs to the small heat shock protein (HSP20) family
K5620_RS01260	COG0477	Major facilitator Superfamily
K5620_RS01285	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K5620_RS01330	COG1012	belongs to the aldehyde dehydrogenase family
K5620_RS01340	COG0010	Belongs to the arginase family
K5620_RS01360	COG1177	transmembrane transport
K5620_RS01365	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5620_RS01370	COG3842	ATPase activity
K5620_RS01375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5620_RS01385	COG0174	glutamine synthetase
K5620_RS01390	COG0174	glutamine synthetase
K5620_RS01395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5620_RS01400	COG4989	oxidoreductase activity
K5620_RS01420	COG0069	glutamate synthase activity
K5620_RS01450	COG2017	converts alpha-aldose to the beta-anomer
K5620_RS01460	COG0402	S-adenosylhomocysteine deaminase activity
K5620_RS01470	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K5620_RS01485	COG3738	Protein conserved in bacteria
K5620_RS01505	COG0390	transport system, permease component
K5620_RS01515	COG3132	Protein of unknown function, DUF480
K5620_RS01520	COG1566	PFAM secretion protein HlyD family protein
K5620_RS01540	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K5620_RS01545	COG0540	Belongs to the ATCase OTCase family
K5620_RS01555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5620_RS01565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K5620_RS01575	COG3031	protein transport across the cell outer membrane
K5620_RS01585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5620_RS01590	COG1459	type II secretion system
K5620_RS01595	COG2165	general secretion pathway protein
K5620_RS01610	COG4795	General secretion pathway protein
K5620_RS01615	COG3156	type II secretion system protein K
K5620_RS01625	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K5620_RS01635	COG1011	Hydrolase
K5620_RS01640	COG0494	nUDIX hydrolase
K5620_RS01645	COG1218	3'(2'),5'-bisphosphate nucleotidase
K5620_RS01655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5620_RS01665	COG2866	Carboxypeptidase
K5620_RS01675	COG0786	glutamate:sodium symporter activity
K5620_RS01680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5620_RS01690	COG0339	signal peptide processing
K5620_RS01695	COG0668	transmembrane transport
K5620_RS01725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5620_RS01730	COG0705	Rhomboid family
K5620_RS01740	COG3161	chorismate lyase activity
K5620_RS01745	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K5620_RS01750	COG2937	Belongs to the GPAT DAPAT family
K5620_RS01765	COG1522	sequence-specific DNA binding
K5620_RS01820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5620_RS01825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K5620_RS01830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K5620_RS01835	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K5620_RS01860	COG1612	heme a metabolic process
K5620_RS01865	COG0109	protoheme IX farnesyltransferase activity
K5620_RS01870	COG0534	Mate efflux family protein
K5620_RS01880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K5620_RS01885	COG2205	protein histidine kinase activity
K5620_RS01890	COG0745	RESPONSE REGULATOR receiver
K5620_RS01895	COG3678	ATP-independent chaperone mediated protein folding
K5620_RS01915	COG3074	FtsZ-dependent cytokinesis
K5620_RS01920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K5620_RS01925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K5620_RS01930	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K5620_RS01955	COG0018	arginyl-trna synthetase
K5620_RS01960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5620_RS01985	COG0626	cystathionine gamma-synthase activity
K5620_RS01990	COG0527	aspartate kinase activity
K5620_RS01990	COG0460	homoserine dehydrogenase
K5620_RS01995	COG0366	Alpha amylase catalytic
K5620_RS02015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5620_RS02025	COG4206	TonB-dependent receptor
K5620_RS02030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K5620_RS02035	COG0724	RNA recognition motif
K5620_RS02070	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5620_RS02075	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5620_RS02080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5620_RS02085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5620_RS02090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5620_RS02095	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5620_RS02105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5620_RS02110	COG1841	ribosomal large subunit assembly
K5620_RS02115	COG0200	Binds to the 23S rRNA
K5620_RS02120	COG0201	protein transport
K5620_RS02125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5620_RS02135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5620_RS02140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5620_RS02145	COG0202	RNA polymerase activity
K5620_RS02150	COG0203	ribosomal protein L17
K5620_RS02155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K5620_RS02160	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K5620_RS02170	COG2239	Acts as a magnesium transporter
K5620_RS02180	COG0488	(ABC) transporter
K5620_RS02190	COG1247	-acetyltransferase
K5620_RS02195	COG2900	Belongs to the SlyX family
K5620_RS02205	COG0545	Peptidyl-prolyl cis-trans isomerase
K5620_RS02220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K5620_RS02230	COG0730	response to heat
K5620_RS02285	COG1047	Peptidyl-prolyl cis-trans
K5620_RS02290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5620_RS02300	COG1175	transmembrane transport
K5620_RS02305	COG0395	ABC-type sugar transport system, permease component
K5620_RS02320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5620_RS02325	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K5620_RS02330	COG3321	synthase
K5620_RS02330	COG1028	Short-chain dehydrogenase reductase Sdr
K5620_RS02330	COG0604	alcohol dehydrogenase
K5620_RS02345	COG2818	Glycosylase
K5620_RS02365	COG0151	Belongs to the GarS family
K5620_RS02370	COG0138	bifunctional purine biosynthesis protein purh
K5620_RS02410	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K5620_RS02415	COG1696	Membrane protein involved in D-alanine export
K5620_RS02425	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K5620_RS02430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5620_RS02455	COG0439	Biotin carboxylase
K5620_RS02460	COG0511	ligase activity, forming carbon-carbon bonds
K5620_RS02465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K5620_RS02475	COG2207	Transcriptional regulator
K5620_RS02480	COG1309	transcriptional regulator
K5620_RS02485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5620_RS02500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K5620_RS02525	COG2205	protein histidine kinase activity
K5620_RS02545	COG1280	lysine exporter protein (LysE YggA)
K5620_RS02565	COG1917	Cupin 2, conserved barrel domain protein
K5620_RS02565	COG4977	sequence-specific DNA binding
K5620_RS02580	COG4232	protein-disulfide reductase activity
K5620_RS02590	COG3030	protein affecting phage T7 exclusion by the F plasmid
K5620_RS02605	COG0459	protein refolding
K5620_RS02630	COG1509	lysine 2,3-aminomutase activity
K5620_RS02635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5620_RS02660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K5620_RS02665	COG1053	succinate dehydrogenase
K5620_RS02670	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K5620_RS02675	COG0471	metal ion transport
K5620_RS02675	COG0490	domain, Protein
K5620_RS02680	COG3264	Mechanosensitive ion channel
K5620_RS02680	COG1511	domain protein
K5620_RS02685	COG0688	phosphatidylethanolamine metabolic process
K5620_RS02690	COG1162	GTPase activity
K5620_RS02695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K5620_RS02725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5620_RS02730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K5620_RS02730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K5620_RS02735	COG0802	atpase or kinase
K5620_RS02745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K5620_RS02750	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5620_RS02755	COG1923	regulation of RNA biosynthetic process
K5620_RS02760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5620_RS02765	COG0330	HflC and HflK could
K5620_RS02770	COG0330	HflC and HflK could
K5620_RS02780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5620_RS02785	COG0142	geranyltranstransferase activity
K5620_RS02790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5620_RS02800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5620_RS02805	COG2966	Psort location CytoplasmicMembrane, score
K5620_RS02810	COG3610	response to peptide
K5620_RS02820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K5620_RS02825	COG2967	ApaG domain
K5620_RS02830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K5620_RS02835	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K5620_RS02840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5620_RS02845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K5620_RS02855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K5620_RS02860	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K5620_RS02865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5620_RS02875	COG0564	pseudouridine synthase activity
K5620_RS02880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5620_RS02905	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K5620_RS02920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5620_RS02945	COG0028	Belongs to the TPP enzyme family
K5620_RS02950	COG0440	acetolactate synthase activity
K5620_RS02955	COG2199	diguanylate cyclase activity
K5620_RS02955	COG2200	EAL domain
K5620_RS02985	COG3267	Type II secretory pathway component ExeA
K5620_RS02985	COG3409	Peptidoglycan-binding domain 1 protein
K5620_RS02995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5620_RS03000	COG1459	type II secretion system
K5620_RS03010	COG2165	general secretion pathway protein
K5620_RS03045	COG1077	Cell shape determining protein MreB Mrl
K5620_RS03050	COG1792	Involved in formation and maintenance of cell shape
K5620_RS03055	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K5620_RS03060	COG0424	maF-like protein
K5620_RS03065	COG1530	ribonuclease E activity
K5620_RS03070	COG3164	Protein of unknown function
K5620_RS03075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K5620_RS03080	COG0312	modulator of DNA gyrase
K5620_RS03090	COG0312	modulator of DNA gyrase
K5620_RS03095	COG2239	Acts as a magnesium transporter
K5620_RS03100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5620_RS03105	COG1660	Displays ATPase and GTPase activities
K5620_RS03110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5620_RS03120	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K5620_RS03125	COG1137	ATPase activity
K5620_RS03130	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K5620_RS03140	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K5620_RS03145	COG0517	IMP dehydrogenase activity
K5620_RS03145	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K5620_RS03155	COG1127	ABC transporter
K5620_RS03160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K5620_RS03165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K5620_RS03170	COG2854	intermembrane phospholipid transfer
K5620_RS03180	COG5007	Belongs to the BolA IbaG family
K5620_RS03185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5620_RS03190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5620_RS03195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5620_RS03205	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K5620_RS03210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5620_RS03215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5620_RS03220	COG0723	plastoquinol--plastocyanin reductase activity
K5620_RS03225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K5620_RS03230	COG2857	Cytochrome c1
K5620_RS03235	COG0625	glutathione transferase activity
K5620_RS03240	COG2969	positive regulation of protein catabolic process
K5620_RS03245	COG2823	Periplasmic or secreted lipoprotein
K5620_RS03255	COG0792	nuclease activity
K5620_RS03260	COG3107	peptidoglycan biosynthetic process
K5620_RS03265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K5620_RS03275	COG2001	Belongs to the MraZ family
K5620_RS03280	COG0275	rRNA processing
K5620_RS03285	COG3116	cell division
K5620_RS03290	COG0768	penicillin binding
K5620_RS03295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5620_RS03300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5620_RS03305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5620_RS03310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5620_RS03315	COG0772	Belongs to the SEDS family
K5620_RS03320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K5620_RS03325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5620_RS03330	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5620_RS03335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K5620_RS03340	COG0849	cell division
K5620_RS03345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5620_RS03350	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K5620_RS03360	COG0739	heme binding
K5620_RS03360	COG0741	lytic transglycosylase activity
K5620_RS03360	COG1196	nuclear chromosome segregation
K5620_RS03365	COG0653	protein targeting
K5620_RS03370	COG0494	nUDIX hydrolase
K5620_RS03375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K5620_RS03385	COG0237	dephospho-CoA kinase activity
K5620_RS03385	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K5620_RS03395	COG1459	type II secretion system
K5620_RS03400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5620_RS03410	COG0157	Belongs to the NadC ModD family
K5620_RS03415	COG3023	N-Acetylmuramoyl-L-alanine amidase
K5620_RS03425	COG2186	Transcriptional regulator
K5620_RS03430	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K5620_RS03435	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5620_RS03440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5620_RS03445	COG1752	Esterase of the alpha-beta hydrolase superfamily
K5620_RS03450	COG1049	propionate catabolic process, 2-methylcitrate cycle
K5620_RS03470	COG0004	ammonium transporteR
K5620_RS03475	COG1840	ABC-type Fe3 transport system, periplasmic component
K5620_RS03490	COG1438	arginine binding
K5620_RS03495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5620_RS03500	COG0039	L-malate dehydrogenase activity
K5620_RS03505	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K5620_RS03510	COG0557	exoribonuclease II activity
K5620_RS03515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5620_RS03520	COG0360	Binds together with S18 to 16S ribosomal RNA
K5620_RS03525	COG2965	DNA replication, synthesis of RNA primer
K5620_RS03530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5620_RS03540	COG4134	Bacterial extracellular solute-binding protein
K5620_RS03545	COG4135	transport system, permease component
K5620_RS03550	COG4136	ATPase activity
K5620_RS03560	COG0305	Participates in initiation and elongation during chromosome replication
K5620_RS03565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5620_RS03570	COG0450	alkyl hydroperoxide reductase
K5620_RS03580	COG1215	transferase activity, transferring glycosyl groups
K5620_RS03600	COG1803	Methylglyoxal synthase
K5620_RS03615	COG0469	pyruvate kinase activity
K5620_RS03620	COG0745	RESPONSE REGULATOR receiver
K5620_RS03630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K5620_RS03640	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
K5620_RS03650	COG0083	homoserine kinase activity
K5620_RS03655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K5620_RS03665	COG1946	Acyl-CoA thioesterase
K5620_RS03670	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K5620_RS03685	COG1115	amino acid carrier protein
K5620_RS03690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5620_RS03695	COG1678	Uncharacterized ACR, COG1678
K5620_RS03700	COG0189	ligase activity
K5620_RS03705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5620_RS03720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K5620_RS03735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K5620_RS03740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K5620_RS03750	COG0191	fructose-bisphosphate aldolase activity
K5620_RS03765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5620_RS03770	COG1538	Outer membrane efflux protein
K5620_RS03775	COG2885	chlorophyll binding
K5620_RS03795	COG1879	ABC-type sugar transport system periplasmic component
K5620_RS03800	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5620_RS03805	COG1129	ABC transporter
K5620_RS03810	COG0673	inositol 2-dehydrogenase activity
K5620_RS03820	COG1609	Transcriptional regulator
K5620_RS03830	COG1012	belongs to the aldehyde dehydrogenase family
K5620_RS03835	COG2186	Transcriptional regulator
K5620_RS03840	COG2814	Major facilitator Superfamily
K5620_RS03845	COG4948	Mandelate Racemase Muconate Lactonizing
K5620_RS03850	COG0800	Aldolase
K5620_RS03855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5620_RS03860	COG0246	Mannitol dehydrogenase
K5620_RS03865	COG1063	alcohol dehydrogenase
K5620_RS03870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K5620_RS03880	COG1609	Transcriptional regulator
K5620_RS03885	COG3250	beta-galactosidase activity
K5620_RS03900	COG4580	involved in the transport of maltose and maltodextrins
K5620_RS03925	COG0840	transmembrane signaling receptor activity
K5620_RS03930	COG2731	YhcH YjgK YiaL family protein
K5620_RS03960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5620_RS03965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K5620_RS03970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5620_RS03975	COG0217	transcriptional regulatory protein
K5620_RS03985	COG0577	efflux transmembrane transporter activity
K5620_RS03985	COG1136	(ABC) transporter
K5620_RS03990	COG1136	(ABC) transporter
K5620_RS04030	COG1609	Transcriptional regulator
K5620_RS04040	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5620_RS04045	COG3279	Response regulator of the LytR AlgR family
K5620_RS04050	COG3275	phosphorelay sensor kinase activity
K5620_RS04080	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K5620_RS04095	COG0006	proline dipeptidase activity
K5620_RS04100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5620_RS04105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5620_RS04120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K5620_RS04125	COG0509	glycine decarboxylation via glycine cleavage system
K5620_RS04160	COG0513	Belongs to the DEAD box helicase family
K5620_RS04175	COG1309	transcriptional regulator
K5620_RS04180	COG1012	belongs to the aldehyde dehydrogenase family
K5620_RS04185	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K5620_RS04200	COG0640	Transcriptional regulator
K5620_RS04205	COG0798	PFAM Bile acid sodium symporter
K5620_RS04210	COG0583	DNA-binding transcription factor activity
K5620_RS04215	COG3384	dioxygenase
K5620_RS04220	COG0435	Glutathione S-transferase
K5620_RS04230	COG0625	glutathione transferase activity
K5620_RS04285	COG0583	DNA-binding transcription factor activity
K5620_RS04290	COG0737	Belongs to the 5'-nucleotidase family
K5620_RS04295	COG0415	Belongs to the DNA photolyase family
K5620_RS04315	COG0789	Transcriptional regulator
K5620_RS04330	COG0110	maltose O-acetyltransferase activity
K5620_RS04335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K5620_RS04415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5620_RS04425	COG0366	Alpha amylase catalytic
K5620_RS04430	COG0840	transmembrane signaling receptor activity
K5620_RS04460	COG0300	oxidoreductase activity
K5620_RS04465	COG2814	Major facilitator Superfamily
K5620_RS04480	COG0513	Belongs to the DEAD box helicase family
K5620_RS04525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K5620_RS04535	COG2201	protein-glutamate methylesterase activity
K5620_RS04545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K5620_RS04550	COG0243	molybdopterin cofactor binding
K5620_RS04555	COG3300	MHYT domain
K5620_RS04555	COG5001	Diguanylate cyclase
K5620_RS04560	COG0840	transmembrane signaling receptor activity
K5620_RS04580	COG2340	Cysteine-rich secretory protein family
K5620_RS04610	COG4580	involved in the transport of maltose and maltodextrins
K5620_RS04620	COG0318	PFAM AMP-dependent synthetase and ligase
K5620_RS04630	COG0583	DNA-binding transcription factor activity
K5620_RS04675	COG0714	Associated with various cellular activities
K5620_RS04700	COG0789	Transcriptional regulator
K5620_RS04705	COG0667	Aldo Keto reductase
K5620_RS04710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5620_RS04715	COG0501	Belongs to the peptidase M48B family
K5620_RS04720	COG1704	LemA family
K5620_RS04725	COG2095	MarC family integral membrane protein
K5620_RS04740	COG2207	Transcriptional regulator
K5620_RS04740	COG1917	Cupin 2, conserved barrel domain protein
K5620_RS04760	COG2067	long-chain fatty acid transport protein
K5620_RS04785	COG0346	lactoylglutathione lyase activity
K5620_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
K5620_RS04795	COG1733	regulation of RNA biosynthetic process
K5620_RS04800	COG0415	Belongs to the DNA photolyase family
K5620_RS04805	COG2217	Heavy metal translocating P-type atpase
K5620_RS04815	COG0583	DNA-binding transcription factor activity
K5620_RS04835	COG3123	guanosine phosphorylase activity
K5620_RS04840	COG3530	Putative quorum-sensing-regulated virulence factor
K5620_RS04845	COG1278	Cold shock
K5620_RS04855	COG1132	(ABC) transporter
K5620_RS04860	COG0513	Belongs to the DEAD box helicase family
K5620_RS04865	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K5620_RS04875	COG1280	lysine exporter protein (LysE YggA)
K5620_RS04885	COG0564	pseudouridine synthase activity
K5620_RS04890	COG1966	Carbon starvation protein
K5620_RS04900	COG3275	phosphorelay sensor kinase activity
K5620_RS04905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5620_RS04910	COG0287	Prephenate dehydrogenase
K5620_RS04910	COG1605	Chorismate mutase
K5620_RS04925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K5620_RS04955	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K5620_RS04965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5620_RS04970	COG1666	GTP binding
K5620_RS04980	COG4941	Belongs to the sigma-70 factor family
K5620_RS04985	COG2211	Major facilitator Superfamily
K5620_RS05000	COG2813	Specifically methylates the guanine in position
K5620_RS05010	COG0271	Belongs to the BolA IbaG family
K5620_RS05020	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5620_RS05030	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5620_RS05035	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5620_RS05040	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5620_RS05045	COG2871	sodium ion transport
K5620_RS05050	COG1477	protein flavinylation
K5620_RS05060	COG0405	Gamma-glutamyltransferase
K5620_RS05075	COG0281	malic enzyme
K5620_RS05085	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K5620_RS05095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K5620_RS05100	COG3693	PFAM glycoside hydrolase, family 10
K5620_RS05100	COG2382	esterase
K5620_RS05105	COG0667	Aldo Keto reductase
K5620_RS05110	COG0583	DNA-binding transcription factor activity
K5620_RS05115	COG0557	exoribonuclease II activity
K5620_RS05120	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K5620_RS05140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5620_RS05150	COG2010	Cytochrome c
K5620_RS05155	COG1979	alcohol dehydrogenase
K5620_RS05165	COG0583	DNA-binding transcription factor activity
K5620_RS05195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5620_RS05205	COG0583	DNA-binding transcription factor activity
K5620_RS05260	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K5620_RS05290	COG3290	protein histidine kinase activity
K5620_RS05295	COG4565	transcriptional regulatory protein
K5620_RS05305	COG0583	DNA-binding transcription factor activity
K5620_RS05310	COG0534	Mate efflux family protein
K5620_RS05315	COG3321	synthase
K5620_RS05315	COG0604	alcohol dehydrogenase
K5620_RS05325	COG1024	Enoyl-CoA hydratase
K5620_RS05345	COG1162	GTPase activity
K5620_RS05350	COG1741	Belongs to the pirin family
K5620_RS05365	COG0784	Response regulator, receiver
K5620_RS05365	COG2205	protein histidine kinase activity
K5620_RS05365	COG5002	protein histidine kinase activity
K5620_RS05405	COG0697	spore germination
K5620_RS05410	COG4628	conserved protein (DUF2132)
K5620_RS05420	COG1054	Belongs to the UPF0176 family
K5620_RS05425	COG0784	Response regulator, receiver
K5620_RS05425	COG0835	chemotaxis
K5620_RS05435	COG1595	DNA-templated transcription, initiation
K5620_RS05450	COG0300	oxidoreductase activity
K5620_RS05465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K5620_RS05485	COG1902	pentaerythritol trinitrate reductase activity
K5620_RS05500	COG0778	Nitroreductase
K5620_RS05510	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5620_RS05520	COG1597	lipid kinase activity
K5620_RS05570	COG0786	glutamate:sodium symporter activity
K5620_RS05575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5620_RS05580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5620_RS05605	COG0745	RESPONSE REGULATOR receiver
K5620_RS05620	COG4269	membrane
K5620_RS05625	COG0501	Belongs to the peptidase M48B family
K5620_RS05630	COG2182	Extracellular solute-binding protein
K5620_RS05660	COG2203	Gaf domain
K5620_RS05660	COG2199	diguanylate cyclase activity
K5620_RS05685	COG1061	Type III restriction enzyme res subunit
K5620_RS05725	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
K5620_RS05735	COG1253	flavin adenine dinucleotide binding
K5620_RS05750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K5620_RS05755	COG2867	negative regulation of translational initiation
K5620_RS05760	COG2914	Belongs to the UPF0125 (RnfH) family
K5620_RS05765	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5620_RS05770	COG0497	DNA recombination
K5620_RS05780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5620_RS05785	COG0732	type I restriction modification DNA specificity domain
K5620_RS05790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K5620_RS05795	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
K5620_RS05820	COG2356	endonuclease I
K5620_RS05895	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5620_RS05900	COG3842	ATPase activity
K5620_RS05905	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5620_RS05910	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5620_RS05915	COG2814	Major facilitator Superfamily
K5620_RS05925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5620_RS05935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K5620_RS05940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5620_RS05945	COG3313	Fe-S protein
K5620_RS05950	COG0288	reversible hydration of carbon dioxide
K5620_RS05955	COG1301	dicarboxylic acid transport
K5620_RS05960	COG0443	Heat shock 70 kDa protein
K5620_RS05965	COG0484	heat shock protein binding
K5620_RS05985	COG0545	Peptidyl-prolyl cis-trans isomerase
K5620_RS05990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5620_RS05995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5620_RS06000	COG1116	anion transmembrane transporter activity
K5620_RS06005	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K5620_RS06020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5620_RS06025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5620_RS06030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5620_RS06040	COG1534	Rna-binding protein
K5620_RS06045	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K5620_RS06050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5620_RS06055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K5620_RS06060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5620_RS06065	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5620_RS06080	COG0779	Required for maturation of 30S ribosomal subunits
K5620_RS06085	COG0195	Participates in both transcription termination and antitermination
K5620_RS06090	COG3064	Membrane
K5620_RS06090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K5620_RS06100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K5620_RS06105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5620_RS06115	COG0590	tRNA wobble adenosine to inosine editing
K5620_RS06120	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K5620_RS06125	COG0047	phosphoribosylformylglycinamidine synthase activity
K5620_RS06125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5620_RS06145	COG3021	interspecies interaction between organisms
K5620_RS06150	COG1388	LysM domain
K5620_RS06150	COG0741	lytic transglycosylase activity
K5620_RS06155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5620_RS06160	COG2226	methyltransferase
K5620_RS06165	COG0328	RNA-DNA hybrid ribonuclease activity
K5620_RS06200	COG3437	response regulator, receiver
K5620_RS06200	COG0784	Response regulator, receiver
K5620_RS06205	COG1960	acyl-CoA dehydrogenase activity
K5620_RS06210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K5620_RS06215	COG0121	glutamine amidotransferase
K5620_RS06220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K5620_RS06225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5620_RS06230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5620_RS06250	COG1393	Belongs to the ArsC family
K5620_RS06255	COG4783	chaperone-mediated protein folding
K5620_RS06270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K5620_RS06275	COG2716	regulation of RNA biosynthetic process
K5620_RS06280	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K5620_RS06310	COG1393	Belongs to the ArsC family
K5620_RS06315	COG2190	(PTS) system
K5620_RS06320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5620_RS06325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5620_RS06330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5620_RS06355	COG3115	cell septum assembly
K5620_RS06360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5620_RS06365	COG2116	formate transmembrane transporter activity
K5620_RS06440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5620_RS06505	COG0765	amino acid transport
K5620_RS06510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5620_RS06530	COG0523	cobalamin synthesis protein
K5620_RS06550	COG2818	Glycosylase
K5620_RS06560	COG1090	epimerase
K5620_RS06575	COG0628	permease
K5620_RS06580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5620_RS06615	COG0280	phosphate acetyltransferase
K5620_RS06615	COG0857	belongs to the CobB CobQ family
K5620_RS06620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5620_RS06640	COG2226	methyltransferase
K5620_RS06645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5620_RS06650	COG1882	Formate acetyltransferase
K5620_RS06665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5620_RS06675	COG4160	amino acid transport
K5620_RS06680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K5620_RS06690	COG0545	Peptidyl-prolyl cis-trans isomerase
K5620_RS06715	COG0788	formyltetrahydrofolate deformylase activity
K5620_RS06720	COG3012	SEC-C Motif Domain Protein
K5620_RS06725	COG0784	Response regulator, receiver
K5620_RS06725	COG3437	response regulator, receiver
K5620_RS06730	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K5620_RS06735	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K5620_RS06750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5620_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
K5620_RS06765	COG0583	DNA-binding transcription factor activity
K5620_RS06770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K5620_RS06790	COG0300	oxidoreductase activity
K5620_RS06805	COG0583	DNA-binding transcription factor activity
K5620_RS06815	COG1454	alcohol dehydrogenase
K5620_RS06815	COG1012	belongs to the aldehyde dehydrogenase family
K5620_RS06825	COG0601	transmembrane transport
K5620_RS06830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5620_RS06835	COG0444	Belongs to the ABC transporter superfamily
K5620_RS06875	COG1342	Belongs to the UPF0251 family
K5620_RS06930	COG2084	Dehydrogenase
K5620_RS06935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5620_RS06940	COG1733	regulation of RNA biosynthetic process
K5620_RS06950	COG1902	pentaerythritol trinitrate reductase activity
K5620_RS06990	COG0765	amino acid transport
K5620_RS06995	COG0765	amino acid transport
K5620_RS07015	COG0745	RESPONSE REGULATOR receiver
K5620_RS07020	COG5002	protein histidine kinase activity
K5620_RS07040	COG0110	maltose O-acetyltransferase activity
K5620_RS07065	COG0514	ATP-dependent DNA helicase (RecQ)
K5620_RS07080	COG1454	alcohol dehydrogenase
K5620_RS07100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5620_RS07175	COG2203	Gaf domain
K5620_RS07175	COG2199	diguanylate cyclase activity
K5620_RS07190	COG1196	nuclear chromosome segregation
K5620_RS07200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5620_RS07225	COG1132	(ABC) transporter
K5620_RS07230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5620_RS07255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K5620_RS07260	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
K5620_RS07265	COG3454	Phosphonate metabolism
K5620_RS07270	COG4778	phosphonate C-P lyase system protein PhnL
K5620_RS07275	COG4107	phosphonate C-P lyase system protein PhnK
K5620_RS07280	COG3627	carbon phosphorus lyase activity
K5620_RS07285	COG3626	phosphonate metabolism
K5620_RS07290	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
K5620_RS07295	COG3624	Phosphonate C-P lyase system protein PhnG
K5620_RS07300	COG2188	Transcriptional regulator
K5620_RS07305	COG3639	organic phosphonate transmembrane transporter activity
K5620_RS07310	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
K5620_RS07315	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K5620_RS07325	COG0561	phosphatase activity
K5620_RS07345	COG3768	UPF0283 membrane protein
K5620_RS07350	COG3106	COG3106 Predicted ATPase
K5620_RS07355	COG0366	Alpha amylase catalytic
K5620_RS07360	COG2814	Major facilitator Superfamily
K5620_RS07365	COG0737	Belongs to the 5'-nucleotidase family
K5620_RS07375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5620_RS07385	COG1278	Cold shock
K5620_RS07390	COG3148	PFAM DTW domain containing protein
K5620_RS07415	COG2207	Transcriptional regulator
K5620_RS07420	COG0702	epimerase
K5620_RS07425	COG0667	Aldo Keto reductase
K5620_RS07435	COG1643	Atp-dependent helicase
K5620_RS07440	COG3038	cytochrome b561
K5620_RS07445	COG2949	membrane
K5620_RS07455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K5620_RS07460	COG0343	queuine tRNA-ribosyltransferase activity
K5620_RS07465	COG1862	Preprotein translocase
K5620_RS07470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5620_RS07475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5620_RS07505	COG1959	2 iron, 2 sulfur cluster binding
K5620_RS07510	COG1104	cysteine desulfurase activity
K5620_RS07515	COG0822	iron-sulfur transferase activity
K5620_RS07520	COG0316	Belongs to the HesB IscA family
K5620_RS07525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K5620_RS07540	COG2975	iron-sulfur cluster assembly
K5620_RS07550	COG0105	UTP biosynthetic process
K5620_RS07555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5620_RS07570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K5620_RS07575	COG0124	histidyl-tRNA synthetase
K5620_RS07585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5620_RS07595	COG1645	bacterial-type flagellum-dependent swarming motility
K5620_RS07600	COG0596	Alpha beta hydrolase
K5620_RS07605	COG1570	exodeoxyribonuclease VII activity
K5620_RS07610	COG0517	IMP dehydrogenase activity
K5620_RS07610	COG0516	GMP reductase activity
K5620_RS07615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5620_RS07615	COG0519	Catalyzes the synthesis of GMP from XMP
K5620_RS07620	COG2814	Major facilitator Superfamily
K5620_RS07625	COG0583	DNA-binding transcription factor activity
K5620_RS07630	COG2363	Small membrane protein
K5620_RS07635	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
K5620_RS07640	COG0473	3-isopropylmalate dehydrogenase activity
K5620_RS07650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5620_RS07655	COG1611	Belongs to the LOG family
K5620_RS07670	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K5620_RS07670	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K5620_RS07680	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K5620_RS07695	COG3098	single-species biofilm formation
K5620_RS07705	COG4580	involved in the transport of maltose and maltodextrins
K5620_RS07720	COG1263	PTS System
K5620_RS07720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5620_RS07730	COG2171	N-acyltransferase activity
K5620_RS07735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K5620_RS07740	COG0024	Methionine aminopeptidase
K5620_RS07745	COG0052	Belongs to the universal ribosomal protein uS2 family
K5620_RS07750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5620_RS07755	COG0528	UMP kinase activity
K5620_RS07760	COG0233	cytoplasmic translational termination
K5620_RS07765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5620_RS07770	COG0575	Belongs to the CDS family
K5620_RS07775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K5620_RS07785	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5620_RS07795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5620_RS07805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5620_RS07810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5620_RS07820	COG0587	DNA-directed DNA polymerase activity
K5620_RS07830	COG0037	tRNA processing
K5620_RS07835	COG3706	GGDEF domain
K5620_RS07845	COG0442	prolyl-tRNA aminoacylation
K5620_RS07850	COG0110	maltose O-acetyltransferase activity
K5620_RS07855	COG1720	tRNA m6t6A37 methyltransferase activity
K5620_RS07865	COG2205	protein histidine kinase activity
K5620_RS07865	COG0784	Response regulator, receiver
K5620_RS07870	COG0840	transmembrane signaling receptor activity
K5620_RS07900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5620_RS07910	COG2350	Protein conserved in bacteria
K5620_RS07925	COG0133	tryptophan synthase activity
K5620_RS07930	COG0135	phosphoribosylanthranilate isomerase activity
K5620_RS07930	COG0134	indole-3-glycerol-phosphate synthase activity
K5620_RS07935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K5620_RS07940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K5620_RS07940	COG0512	Glutamine amidotransferase of anthranilate synthase
K5620_RS07945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K5620_RS07950	COG0613	PHP domain protein
K5620_RS07955	COG0009	L-threonylcarbamoyladenylate synthase
K5620_RS07965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5620_RS07970	COG1187	pseudouridine synthase activity
K5620_RS07985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5620_RS07990	COG0215	cysteine-tRNA ligase activity
K5620_RS08000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K5620_RS08005	COG2985	domain, Protein
K5620_RS08075	COG0395	ABC-type sugar transport system, permease component
K5620_RS08080	COG0673	inositol 2-dehydrogenase activity
K5620_RS08085	COG2165	general secretion pathway protein
K5620_RS08090	COG0544	peptidyl-prolyl cis-trans isomerase activity
K5620_RS08095	COG0740	serine-type endopeptidase activity
K5620_RS08100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5620_RS08110	COG1320	monovalent cation:proton antiporter activity
K5620_RS08115	COG2212	antiporter activity
K5620_RS08120	COG1863	multisubunit Na H antiporter MnhE subunit
K5620_RS08125	COG0651	ATP synthesis coupled electron transport
K5620_RS08130	COG1006	Multisubunit Na H antiporter MnhC subunit
K5620_RS08135	COG2111	Na H antiporter
K5620_RS08135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K5620_RS08160	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K5620_RS08210	COG1690	Belongs to the RtcB family
K5620_RS08215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K5620_RS08225	COG0778	Nitroreductase
K5620_RS08235	COG0402	S-adenosylhomocysteine deaminase activity
K5620_RS08240	COG2351	hydroxyisourate hydrolase activity
K5620_RS08255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K5620_RS08260	COG2080	2 iron, 2 sulfur cluster binding
K5620_RS08275	COG3401	FG-GAP repeat protein
K5620_RS08280	COG2233	PERMEase
K5620_RS08325	COG0737	Belongs to the 5'-nucleotidase family
K5620_RS08330	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5620_RS08335	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5620_RS08340	COG3845	ABC transporter
K5620_RS08370	COG1404	Belongs to the peptidase S8 family
K5620_RS08390	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K5620_RS08410	COG0826	peptidase U32
K5620_RS08505	COG0840	transmembrane signaling receptor activity
K5620_RS08515	COG4533	DNA binding
K5620_RS08525	COG0438	transferase activity, transferring glycosyl groups
K5620_RS08530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5620_RS08535	COG3621	Patatin-like phospholipase
K5620_RS08550	COG0110	maltose O-acetyltransferase activity
K5620_RS08555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5620_RS08560	COG2824	Alkylphosphonate utilization operon protein PhnA
K5620_RS08565	COG0840	transmembrane signaling receptor activity
K5620_RS08595	COG2205	protein histidine kinase activity
K5620_RS08595	COG0784	Response regulator, receiver
K5620_RS08600	COG2204	response regulator
K5620_RS08610	COG0500	methyltransferase
K5620_RS08625	COG0438	transferase activity, transferring glycosyl groups
K5620_RS08640	COG0601	transmembrane transport
K5620_RS08645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5620_RS08650	COG4172	Belongs to the ABC transporter superfamily
K5620_RS08675	COG1335	isochorismatase
K5620_RS08680	COG1215	transferase activity, transferring glycosyl groups
K5620_RS08690	COG1216	Glycosyl transferase, family 2
K5620_RS08695	COG1215	transferase activity, transferring glycosyl groups
K5620_RS08710	COG0438	transferase activity, transferring glycosyl groups
K5620_RS08725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5620_RS08730	COG2501	S4 domain
K5620_RS08775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5620_RS08800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5620_RS08825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5620_RS08840	COG2719	SpoVR family
K5620_RS08845	COG2718	Belongs to the UPF0229 family
K5620_RS08850	COG2766	serine protein kinase
K5620_RS08855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5620_RS08880	COG0604	alcohol dehydrogenase
K5620_RS08885	COG0583	DNA-binding transcription factor activity
K5620_RS08905	COG2186	Transcriptional regulator
K5620_RS08920	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
K5620_RS08945	COG1917	Cupin 2, conserved barrel domain protein
K5620_RS08955	COG0800	Aldolase
K5620_RS08960	COG0456	acetyltransferase
K5620_RS08995	COG0513	Belongs to the DEAD box helicase family
K5620_RS09010	COG0066	3-isopropylmalate dehydratase activity
K5620_RS09015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K5620_RS09020	COG0366	Alpha amylase catalytic
K5620_RS09050	COG2200	EAL domain
K5620_RS09065	COG0420	3'-5' exonuclease activity
K5620_RS09070	COG0419	ATPase involved in DNA repair
K5620_RS09085	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K5620_RS09095	COG0730	response to heat
K5620_RS09100	COG1199	ATP-dependent helicase activity
K5620_RS09120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5620_RS09125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5620_RS09130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5620_RS09135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5620_RS09145	COG0367	asparagine synthase
K5620_RS09155	COG0647	UMP catabolic process
K5620_RS09160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5620_RS09170	COG1560	Kdo2-lipid A biosynthetic process
K5620_RS09195	COG3693	PFAM glycoside hydrolase, family 10
K5620_RS09200	COG0589	response to stress
K5620_RS09210	COG0622	Phosphoesterase
K5620_RS09230	COG2824	Alkylphosphonate utilization operon protein PhnA
K5620_RS09255	COG2105	PFAM AIG2 family protein
K5620_RS09260	COG0659	secondary active sulfate transmembrane transporter activity
K5620_RS09270	COG0583	DNA-binding transcription factor activity
K5620_RS09275	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K5620_RS09275	COG0140	phosphoribosyl-ATP diphosphatase activity
K5620_RS09280	COG0107	imidazoleglycerol-phosphate synthase activity
K5620_RS09285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K5620_RS09290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K5620_RS09295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K5620_RS09295	COG0131	Imidazoleglycerol-phosphate dehydratase
K5620_RS09300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5620_RS09305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K5620_RS09310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K5620_RS09320	COG1199	ATP-dependent helicase activity
K5620_RS09325	COG1214	PFAM Peptidase M22, glycoprotease
K5620_RS09335	COG1073	alpha beta
K5620_RS09335	COG2226	methyltransferase
K5620_RS09340	COG0318	PFAM AMP-dependent synthetase and ligase
K5620_RS09345	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K5620_RS09350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K5620_RS09355	COG2894	cell division
K5620_RS09360	COG0850	regulation of cytokinetic process
K5620_RS09365	COG3100	YcgL domain-containing protein
K5620_RS09370	COG2951	lytic endotransglycosylase activity
K5620_RS09375	COG0179	Fumarylacetoacetate (FAA) hydrolase
K5620_RS09380	COG2983	Belongs to the UPF0260 family
K5620_RS09385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K5620_RS09390	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K5620_RS09395	COG2186	Transcriptional regulator
K5620_RS09405	COG2119	membrane
K5620_RS09410	COG0023	Translation Initiation Factor
K5620_RS09420	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K5620_RS09430	COG4943	cyclic-guanylate-specific phosphodiesterase activity
K5620_RS09435	COG1940	carbohydrate kinase activity
K5620_RS09435	COG1846	Transcriptional regulator
K5620_RS09440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K5620_RS09445	COG0363	glucosamine-6-phosphate deaminase activity
K5620_RS09450	COG1263	PTS System
K5620_RS09450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5620_RS09470	COG1881	PFAM PEBP family protein
K5620_RS09485	COG1280	lysine exporter protein (LysE YggA)
K5620_RS09500	COG3604	Transcriptional regulator
K5620_RS09520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5620_RS09555	COG2850	peptidyl-arginine hydroxylation
K5620_RS09560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5620_RS09575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5620_RS09580	COG0326	Molecular chaperone. Has ATPase activity
K5620_RS09585	COG2182	Extracellular solute-binding protein
K5620_RS09590	COG3706	GGDEF domain
K5620_RS09600	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K5620_RS09610	COG0488	(ABC) transporter
K5620_RS09620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5620_RS09625	COG2915	High frequency lysogenization protein hflD homolog
K5620_RS09630	COG0482	sulfurtransferase activity
K5620_RS09635	COG1187	pseudouridine synthase activity
K5620_RS09645	COG1278	Cold shock
K5620_RS09650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K5620_RS09655	COG0542	response to heat
K5620_RS09660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K5620_RS09665	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K5620_RS09670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K5620_RS09675	COG0492	ferredoxin-NADP+ reductase activity
K5620_RS09690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K5620_RS09695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5620_RS09700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5620_RS09705	COG2920	part of a sulfur-relay system
K5620_RS09710	COG1289	transmembrane transporter activity
K5620_RS09715	COG0670	Belongs to the BI1 family
K5620_RS09720	COG1227	inorganic diphosphatase activity
K5620_RS09725	COG0067	glutamate synthase
K5620_RS09725	COG0070	glutamate synthase
K5620_RS09725	COG0069	glutamate synthase activity
K5620_RS09730	COG0493	'glutamate synthase
K5620_RS09740	COG2197	response regulator
K5620_RS09745	COG0322	excinuclease ABC activity
K5620_RS09805	COG1116	anion transmembrane transporter activity
K5620_RS09820	COG4770	biotin carboxylase activity
K5620_RS09860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5620_RS09890	COG2807	transmembrane transport
K5620_RS09925	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5620_RS09940	COG0583	DNA-binding transcription factor activity
K5620_RS09945	COG2814	Major facilitator Superfamily
K5620_RS09965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5620_RS09970	COG0516	GMP reductase activity
K5620_RS09970	COG0517	IMP dehydrogenase activity
K5620_RS09985	COG3142	Participates in the control of copper homeostasis
K5620_RS09990	COG0584	glycerophosphoryl diester phosphodiesterase
K5620_RS10005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K5620_RS10015	COG0583	DNA-binding transcription factor activity
K5620_RS10020	COG1028	Short-chain dehydrogenase reductase Sdr
K5620_RS10030	COG0616	signal peptide processing
K5620_RS10035	COG3724	N-succinylarginine dihydrolase activity
K5620_RS10090	COG2855	membrane
K5620_RS10095	COG1752	Esterase of the alpha-beta hydrolase superfamily
K5620_RS10110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5620_RS10115	COG0632	four-way junction helicase activity
K5620_RS10120	COG2255	four-way junction helicase activity
K5620_RS10125	COG0824	Thioesterase
K5620_RS10130	COG0811	peptide transport
K5620_RS10145	COG0823	Involved in the tonB-independent uptake of proteins
K5620_RS10150	COG2885	chlorophyll binding
K5620_RS10155	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K5620_RS10190	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K5620_RS10200	COG0676	glucose-6-phosphate 1-epimerase activity
K5620_RS10210	COG1640	4-alpha-glucanotransferase
K5620_RS10215	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K5620_RS10225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5620_RS10235	COG3139	Protein of unknown function (DUF1315)
K5620_RS10240	COG0252	asparaginase activity
K5620_RS10245	COG0616	signal peptide processing
K5620_RS10250	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5620_RS10250	COG1902	pentaerythritol trinitrate reductase activity
K5620_RS10255	COG0778	Nitroreductase
K5620_RS10270	COG0017	Asparaginyl-tRNA synthetase
K5620_RS10280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K5620_RS10285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K5620_RS10290	COG0156	8-amino-7-oxononanoate synthase activity
K5620_RS10300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K5620_RS10305	COG0501	Belongs to the peptidase M48B family
K5620_RS10320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5620_RS10325	COG1763	Mo-molybdopterin cofactor biosynthetic process
K5620_RS10330	COG0729	surface antigen
K5620_RS10335	COG2911	Protein conserved in bacteria
K5620_RS10345	COG2211	Major facilitator Superfamily
K5620_RS10350	COG3118	belongs to the thioredoxin family
K5620_RS10355	COG0745	RESPONSE REGULATOR receiver
K5620_RS10365	COG1322	Protein conserved in bacteria
K5620_RS10370	COG0366	Alpha amylase catalytic
K5620_RS10375	COG3706	GGDEF domain
K5620_RS10380	COG1187	pseudouridine synthase activity
K5620_RS10395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5620_RS10410	COG0163	prenyltransferase activity
K5620_RS10415	COG0735	belongs to the Fur family
K5620_RS10425	COG0741	lytic transglycosylase activity
K5620_RS10445	COG0596	Alpha beta hydrolase
K5620_RS10450	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K5620_RS10455	COG0033	Phosphoglucomutase
K5620_RS10460	COG0058	SHG alpha-glucan phosphorylase activity
K5620_RS10465	COG2988	succinylglutamate desuccinylase activity
K5620_RS10470	COG0247	lactate metabolic process
K5620_RS10470	COG0277	FAD linked oxidase domain protein
K5620_RS10475	COG2050	protein possibly involved in aromatic compounds catabolism
K5620_RS10500	COG4221	oxidoreductase activity
K5620_RS10535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5620_RS10535	COG0116	Belongs to the methyltransferase superfamily
K5620_RS10545	COG0488	(ABC) transporter
K5620_RS10555	COG3130	regulation of translation
K5620_RS10560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5620_RS10565	COG1067	ATP-dependent peptidase activity
K5620_RS10570	COG2056	Na+-H+ antiporter family
K5620_RS10575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5620_RS10590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5620_RS10595	COG4660	Part of a membrane complex involved in electron transport
K5620_RS10600	COG4659	FMN binding
K5620_RS10605	COG4658	electron transport chain
K5620_RS10610	COG4656	Part of a membrane complex involved in electron transport
K5620_RS10620	COG4657	Part of a membrane complex involved in electron transport
K5620_RS10625	COG1328	CTP reductase activity
K5620_RS10630	COG0602	queuosine metabolic process
K5620_RS10635	COG2202	Pas domain
K5620_RS10635	COG2199	diguanylate cyclase activity
K5620_RS10635	COG2200	EAL domain
K5620_RS10665	COG0556	nucleotide-excision repair
K5620_RS10670	COG0149	triose-phosphate isomerase activity
K5620_RS10675	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K5620_RS10680	COG1448	Aminotransferase
K5620_RS10690	COG3437	response regulator, receiver
K5620_RS10690	COG0784	Response regulator, receiver
K5620_RS10700	COG0653	protein targeting
K5620_RS10705	COG3046	protein related to deoxyribodipyrimidine photolyase
K5620_RS10740	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K5620_RS10745	COG3639	organic phosphonate transmembrane transporter activity
K5620_RS10750	COG3454	Phosphonate metabolism
K5620_RS10765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5620_RS10770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5620_RS10805	COG3437	response regulator, receiver
K5620_RS10810	COG3437	response regulator, receiver
K5620_RS10815	COG3278	Belongs to the heme-copper respiratory oxidase family
K5620_RS10830	COG2010	Cytochrome c
K5620_RS10840	COG2217	Heavy metal translocating P-type atpase
K5620_RS10855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5620_RS10860	COG0589	response to stress
K5620_RS10865	COG0037	tRNA processing
K5620_RS10870	COG2992	FlgJ-related protein
K5620_RS10875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5620_RS10880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5620_RS10885	COG4597	amino acid ABC transporter
K5620_RS10890	COG0765	amino acid transport
K5620_RS10895	COG1126	abc transporter atp-binding protein
K5620_RS10900	COG0776	regulation of translation
K5620_RS10905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5620_RS10905	COG0072	phenylalanine-tRNA ligase activity
K5620_RS10910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5620_RS10915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5620_RS10920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5620_RS10925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5620_RS10930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5620_RS10940	COG0307	riboflavin synthase, alpha
K5620_RS10945	COG0534	Mate efflux family protein
K5620_RS10965	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K5620_RS11015	COG4657	Part of a membrane complex involved in electron transport
K5620_RS11020	COG2878	Part of a membrane complex involved in electron transport
K5620_RS11025	COG4656	Part of a membrane complex involved in electron transport
K5620_RS11030	COG4658	electron transport chain
K5620_RS11050	COG0716	FMN binding
K5620_RS11065	COG4302	ethanolamine ammonia-lyase activity
K5620_RS11070	COG4303	Ethanolamine ammonia lyase large subunit
K5620_RS11080	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K5620_RS11090	COG2207	Transcriptional regulator
K5620_RS11120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5620_RS11125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5620_RS11175	COG3383	formate dehydrogenase (NAD+) activity
K5620_RS11210	COG2814	Major facilitator Superfamily
K5620_RS11245	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
K5620_RS11265	COG1538	Outer membrane efflux protein
K5620_RS11285	COG1063	alcohol dehydrogenase
K5620_RS11290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5620_RS11290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5620_RS11320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5620_RS11335	COG0038	chloride channel
K5620_RS11340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K5620_RS11345	COG1012	belongs to the aldehyde dehydrogenase family
K5620_RS11355	COG3681	Belongs to the UPF0597 family
K5620_RS11360	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K5620_RS11375	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K5620_RS11380	COG1956	GAF domain-containing protein
K5620_RS11385	COG3141	response to X-ray
K5620_RS11395	COG2995	paraquat-inducible protein a
K5620_RS11400	COG3008	intermembrane lipid transfer
K5620_RS11405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5620_RS11405	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K5620_RS11410	COG0084	hydrolase, TatD family'
K5620_RS11415	COG0470	DNA polymerase III
K5620_RS11420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5620_RS11425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5620_RS11430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5620_RS11435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5620_RS11440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5620_RS11455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5620_RS11465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5620_RS11470	COG1399	metal-binding, possibly nucleic acid-binding protein
K5620_RS11475	COG0424	maF-like protein
K5620_RS11485	COG1530	ribonuclease E activity
K5620_RS11500	COG0572	uridine kinase
K5620_RS11505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5620_RS11505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5620_RS11510	COG1254	Belongs to the acylphosphatase family
K5620_RS11525	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K5620_RS11540	COG0314	molybdopterin synthase activity
K5620_RS11545	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K5620_RS11550	COG0315	cyclic pyranopterin monophosphate synthase activity
K5620_RS11555	COG0521	Mo-molybdopterin cofactor biosynthetic process
K5620_RS11560	COG0746	molybdenum cofactor guanylyltransferase activity
K5620_RS11570	COG3005	denitrification pathway
K5620_RS11580	COG0243	molybdopterin cofactor binding
K5620_RS11590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5620_RS11590	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5620_RS11595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K5620_RS11600	COG3850	Histidine kinase
K5620_RS11605	COG2197	response regulator
K5620_RS11615	COG1032	radical SAM domain protein
K5620_RS11620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5620_RS11630	COG2223	nitrite transmembrane transporter activity
K5620_RS11650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5620_RS11680	COG0583	DNA-binding transcription factor activity
K5620_RS11690	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K5620_RS11700	COG2985	domain, Protein
K5620_RS11705	COG0076	glutamate decarboxylase activity
K5620_RS11715	COG0837	glucose binding
K5620_RS11720	COG1737	Transcriptional regulator
K5620_RS11725	COG1960	acyl-CoA dehydrogenase activity
K5620_RS11745	COG3220	belongs to the UPF0276 family
K5620_RS11760	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
K5620_RS11760	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
K5620_RS11775	COG1760	l-serine dehydratase
K5620_RS11780	COG2010	Cytochrome c
K5620_RS11795	COG0668	transmembrane transport
K5620_RS11825	COG0583	DNA-binding transcription factor activity
K5620_RS11835	COG4181	ATPase activity
K5620_RS11850	COG0167	dihydroorotate dehydrogenase activity
K5620_RS11855	COG2902	Dehydrogenase
K5620_RS11865	COG0308	aminopeptidase N
K5620_RS11870	COG0733	neurotransmitter:sodium symporter activity
K5620_RS11880	COG0513	Belongs to the DEAD box helicase family
K5620_RS11885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K5620_RS11900	COG1643	Atp-dependent helicase
K5620_RS11905	COG0517	IMP dehydrogenase activity
K5620_RS11905	COG0617	tRNA 3'-terminal CCA addition
K5620_RS11905	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K5620_RS11910	COG0418	dihydroorotase activity
K5620_RS11915	COG4999	Histidine kinase
K5620_RS11915	COG3437	response regulator, receiver
K5620_RS11915	COG2205	protein histidine kinase activity
K5620_RS11915	COG3850	Histidine kinase
K5620_RS11925	COG2925	Exonuclease
K5620_RS11935	COG3345	alpha-galactosidase
K5620_RS11940	COG0295	cytidine deaminase activity
K5620_RS11945	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K5620_RS11960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K5620_RS11975	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K5620_RS11995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5620_RS12010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5620_RS12025	COG0517	IMP dehydrogenase activity
K5620_RS12055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5620_RS12065	COG1028	Short-chain dehydrogenase reductase Sdr
K5620_RS12080	COG1187	pseudouridine synthase activity
K5620_RS12105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5620_RS12150	COG0205	6-phosphofructokinase activity
K5620_RS12165	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K5620_RS12175	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5620_RS12180	COG0567	Dehydrogenase, E1 component
K5620_RS12185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K5620_RS12190	COG1053	succinate dehydrogenase
K5620_RS12195	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K5620_RS12205	COG0372	Belongs to the citrate synthase family
K5620_RS12220	COG2835	tetraacyldisaccharide 4'-kinase activity
K5620_RS12225	COG1663	tetraacyldisaccharide 4'-kinase activity
K5620_RS12230	COG1132	(ABC) transporter
K5620_RS12235	COG0658	competence protein
K5620_RS12235	COG2333	competence protein COMEC
K5620_RS12245	COG4591	ABC-type transport system involved in lipoprotein release permease component
K5620_RS12250	COG1136	(ABC) transporter
K5620_RS12255	COG4591	ABC-type transport system involved in lipoprotein release permease component
K5620_RS12265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5620_RS12280	COG1252	NADH dehydrogenase
K5620_RS12290	COG1472	Belongs to the glycosyl hydrolase 3 family
K5620_RS12325	COG3842	ATPase activity
K5620_RS12330	COG3833	ABC-type maltose transport systems, permease component
K5620_RS12335	COG1175	transmembrane transport
K5620_RS12340	COG2182	Extracellular solute-binding protein
K5620_RS12345	COG3081	Nucleoid-associated protein
K5620_RS12355	COG3083	sulfuric ester hydrolase activity
K5620_RS12380	COG0848	biopolymer transport protein
K5620_RS12385	COG0811	peptide transport
K5620_RS12390	COG0811	peptide transport
K5620_RS12400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5620_RS12405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K5620_RS12410	COG1120	ATPase activity
K5620_RS12420	COG4774	siderophore transport
K5620_RS12425	COG2207	Transcriptional regulator
K5620_RS12425	COG3708	Transcriptional regulator
K5620_RS12435	COG4221	oxidoreductase activity
K5620_RS12460	COG0745	RESPONSE REGULATOR receiver
K5620_RS12465	COG2205	protein histidine kinase activity
K5620_RS12475	COG5001	Diguanylate cyclase
K5620_RS12475	COG5002	protein histidine kinase activity
K5620_RS12485	COG0626	cystathionine gamma-synthase activity
K5620_RS12490	COG0473	3-isopropylmalate dehydrogenase activity
K5620_RS12510	COG1842	Phage shock protein A
K5620_RS12515	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5620_RS12525	COG4168	peptide transport system, permease
K5620_RS12530	COG4171	peptide transport system, permease
K5620_RS12540	COG4172	Belongs to the ABC transporter superfamily
K5620_RS12550	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5620_RS12560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5620_RS12565	COG0776	regulation of translation
K5620_RS12570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K5620_RS12575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K5620_RS12580	COG0217	transcriptional regulatory protein
K5620_RS12600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5620_RS12605	COG4106	trans-aconitate 2-methyltransferase activity
K5620_RS12625	COG0840	transmembrane signaling receptor activity
K5620_RS12635	COG0500	methyltransferase
K5620_RS12640	COG0189	ligase activity
K5620_RS12640	COG4067	protein conserved in archaea
K5620_RS12655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K5620_RS12660	COG1286	toxin biosynthetic process
K5620_RS12665	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K5620_RS12670	COG0285	dihydrofolate synthase activity
K5620_RS12675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K5620_RS12680	COG0101	tRNA pseudouridine synthase activity
K5620_RS12690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K5620_RS12695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5620_RS12700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5620_RS12705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5620_RS12705	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K5620_RS12715	COG2201	protein-glutamate methylesterase activity
K5620_RS12720	COG3706	GGDEF domain
K5620_RS12735	COG3101	peptidyl-lysine hydroxylation
K5620_RS12740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5620_RS12745	COG2890	protein-(glutamine-N5) methyltransferase activity
K5620_RS12750	COG2840	Smr protein MutS2
K5620_RS12760	COG2062	phosphohistidine phosphatase, SixA
K5620_RS12775	COG0183	Belongs to the thiolase family
K5620_RS12780	COG0714	Associated with various cellular activities
K5620_RS12810	COG3691	Protein conserved in bacteria
K5620_RS12815	COG1595	DNA-templated transcription, initiation
K5620_RS12825	COG2067	long-chain fatty acid transport protein
K5620_RS12840	COG1757	Na H antiporter
K5620_RS12845	COG2916	Histone family protein nucleoid-structuring protein H-NS
K5620_RS12850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5620_RS12855	COG0602	queuosine metabolic process
K5620_RS12860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K5620_RS12870	COG0284	orotidine-5'-phosphate decarboxylase activity
K5620_RS12875	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K5620_RS12880	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K5620_RS12885	COG0776	regulation of translation
K5620_RS12890	COG0539	negative regulation of cytoplasmic translation
K5620_RS12895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5620_RS12915	COG1086	Polysaccharide biosynthesis protein
K5620_RS12920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5620_RS12925	COG1083	cytidylyl-transferase
K5620_RS12940	COG2226	methyltransferase
K5620_RS12980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5620_RS12990	COG2089	acid synthase
K5620_RS13025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K5620_RS13050	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5620_RS13050	COG3951	Flagellar rod assembly protein muramidase FlgJ
K5620_RS13055	COG1706	bacterial-type flagellum-dependent cell motility
K5620_RS13060	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K5620_RS13070	COG4786	Flagellar basal body rod
K5620_RS13090	COG1815	bacterial-type flagellum-dependent cell motility
K5620_RS13095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K5620_RS13100	COG0784	Response regulator, receiver
K5620_RS13100	COG0835	chemotaxis
K5620_RS13160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5620_RS13165	COG1085	galactose-1-phosphate uridylyltransferase
K5620_RS13170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5620_RS13175	COG1022	Amp-dependent synthetase and ligase
K5620_RS13190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5620_RS13200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5620_RS13205	COG0438	transferase activity, transferring glycosyl groups
K5620_RS13235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5620_RS13255	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K5620_RS13285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5620_RS13315	COG1083	cytidylyl-transferase
K5620_RS13320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5620_RS13335	COG2089	acid synthase
K5620_RS13340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5620_RS13345	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K5620_RS13355	COG0662	Cupin 2, conserved barrel domain protein
K5620_RS13355	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K5620_RS13360	COG1051	belongs to the nudix hydrolase family
K5620_RS13390	COG0529	Catalyzes the synthesis of activated sulfate
K5620_RS13395	COG0471	metal ion transport
K5620_RS13395	COG3273	potassium ion transport
K5620_RS13400	COG2895	sulfate adenylyltransferase (ATP) activity
K5620_RS13405	COG0175	sulfate reduction
K5620_RS13425	COG3088	subunit of a heme lyase
K5620_RS13425	COG4235	cytochrome complex assembly
K5620_RS13430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5620_RS13435	COG1138	Cytochrome C-type biogenesis protein
K5620_RS13440	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K5620_RS13445	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K5620_RS13450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K5620_RS13455	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K5620_RS13460	COG4133	protoheme IX ABC transporter activity
K5620_RS13470	COG0835	chemotaxis
K5620_RS13480	COG1192	Involved in chromosome partitioning
K5620_RS13485	COG1360	Flagellar Motor Protein
K5620_RS13490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K5620_RS13495	COG2201	protein-glutamate methylesterase activity
K5620_RS13500	COG2198	Histidine kinase
K5620_RS13500	COG0784	Response regulator, receiver
K5620_RS13500	COG0643	Histidine kinase
K5620_RS13505	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K5620_RS13530	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K5620_RS13540	COG1684	flagellar biosynthetic protein fliR
K5620_RS13545	COG1987	bacterial-type flagellum assembly
K5620_RS13595	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K5620_RS13600	COG1766	The M ring may be actively involved in energy transduction
K5620_RS13605	COG1677	Flagellar hook-basal body complex protein FliE
K5620_RS13610	COG2203	Gaf domain
K5620_RS13610	COG4251	negative regulation of phosphorylation
K5620_RS13610	COG5001	Diguanylate cyclase
K5620_RS13610	COG3706	GGDEF domain
K5620_RS13615	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K5620_RS13625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5620_RS13640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5620_RS13650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5620_RS13655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5620_RS13660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K5620_RS13680	COG0436	Aminotransferase
K5620_RS13685	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K5620_RS13690	COG0517	IMP dehydrogenase activity
K5620_RS13715	COG0704	Plays a role in the regulation of phosphate uptake
K5620_RS13720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5620_RS13725	COG0581	inorganic phosphate transmembrane transporter activity
K5620_RS13740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K5620_RS13745	COG1418	mRNA catabolic process
K5620_RS13755	COG3655	Transcriptional regulator
K5620_RS13780	COG3250	beta-galactosidase activity
K5620_RS13795	COG2837	iron assimilation
K5620_RS13815	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K5620_RS13820	COG5002	protein histidine kinase activity
K5620_RS13825	COG0745	RESPONSE REGULATOR receiver
K5620_RS13830	COG3769	mannosylglycerate metabolic process
K5620_RS13835	COG1215	transferase activity, transferring glycosyl groups
K5620_RS13865	COG0366	Alpha amylase catalytic
K5620_RS13885	COG1733	regulation of RNA biosynthetic process
K5620_RS13900	COG2974	May be involved in recombination
K5620_RS13905	COG0826	peptidase U32
K5620_RS13910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5620_RS13950	COG0519	Catalyzes the synthesis of GMP from XMP
K5620_RS13960	COG1346	cytolysis
K5620_RS13965	COG1380	Effector of murein hydrolase LrgA
K5620_RS13970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5620_RS14010	COG4464	protein tyrosine phosphatase activity
K5620_RS14055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5620_RS14090	COG2358	TRAP transporter, solute receptor (TAXI family
K5620_RS14100	COG3034	peptidoglycan biosynthetic process
K5620_RS14120	COG3154	lipid carrier protein
K5620_RS14125	COG0826	peptidase U32
K5620_RS14130	COG0826	peptidase U32
K5620_RS14140	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K5620_RS14145	COG2912	Transglutaminase-like superfamily
K5620_RS14150	COG2890	protein-(glutamine-N5) methyltransferase activity
K5620_RS14155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5620_RS14160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K5620_RS14165	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K5620_RS14170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5620_RS14180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K5620_RS14185	COG0193	aminoacyl-tRNA hydrolase activity
K5620_RS14230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5620_RS14240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5620_RS14245	COG1702	phosphate starvation-inducible protein PhoH
K5620_RS14250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5620_RS14255	COG4535	Mg2 and Co2 transporter CorC
K5620_RS14260	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K5620_RS14265	COG2888	peptidyl-tyrosine sulfation
K5620_RS14270	COG0495	leucyl-tRNA aminoacylation
K5620_RS14280	COG1466	dna polymerase III delta subunit
K5620_RS14285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5620_RS14290	COG0799	negative regulation of ribosome biogenesis
K5620_RS14295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K5620_RS14300	COG0768	penicillin binding
K5620_RS14305	COG0772	Belongs to the SEDS family
K5620_RS14310	COG2951	lytic endotransglycosylase activity
K5620_RS14315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K5620_RS14320	COG1686	Belongs to the peptidase S11 family
K5620_RS14325	COG2921	Belongs to the UPF0250 family
K5620_RS14330	COG0321	lipoyl(octanoyl) transferase activity
K5620_RS14335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K5620_RS14360	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K5620_RS14365	COG0583	DNA-binding transcription factor activity
K5620_RS14385	COG0840	transmembrane signaling receptor activity
K5620_RS14395	COG3284	Transcriptional regulator
K5620_RS14405	COG4221	oxidoreductase activity
K5620_RS14415	COG3250	beta-galactosidase activity
K5620_RS14430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K5620_RS14435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K5620_RS14445	COG1073	alpha beta
K5620_RS14450	COG2252	PERMEase
K5620_RS14455	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5620_RS14465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5620_RS14485	COG0346	lactoylglutathione lyase activity
K5620_RS14490	COG5001	Diguanylate cyclase
K5620_RS14495	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K5620_RS14500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K5620_RS14505	COG1058	Belongs to the CinA family
K5620_RS14505	COG1546	Belongs to the CinA family
K5620_RS14510	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K5620_RS14515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5620_RS14520	COG1609	Transcriptional regulator
K5620_RS14525	COG0259	pyridoxamine-phosphate oxidase activity
K5620_RS14530	COG0741	lytic transglycosylase activity
K5620_RS14535	COG4172	Belongs to the ABC transporter superfamily
K5620_RS14540	COG4239	(ABC) transporter, permease
K5620_RS14545	COG4174	ABC transporter (Permease)
K5620_RS14550	COG4166	transmembrane transport
K5620_RS14560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K5620_RS14565	COG0077	Prephenate dehydratase
K5620_RS14565	COG1605	Chorismate mutase
K5620_RS14570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5620_RS14575	COG4137	Cytochrome C assembly protein
K5620_RS14580	COG4536	flavin adenine dinucleotide binding
K5620_RS14595	COG2918	glutathione biosynthetic process
K5620_RS14600	COG0612	Peptidase, M16
K5620_RS14605	COG1238	metal cluster binding
K5620_RS14610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5620_RS14620	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K5620_RS14625	COG0511	ligase activity, forming carbon-carbon bonds
K5620_RS14625	COG5016	pyruvate
K5620_RS14675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K5620_RS14685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5620_RS14695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5620_RS14700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5620_RS14705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5620_RS14715	COG1238	metal cluster binding
K5620_RS14720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K5620_RS14725	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K5620_RS14730	COG0585	pseudouridine synthase activity
K5620_RS14735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K5620_RS14745	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K5620_RS14750	COG0148	phosphopyruvate hydratase activity
K5620_RS14755	COG0504	CTP synthase activity
K5620_RS14760	COG3956	TIGRFAM MazG family protein
K5620_RS14765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5620_RS14770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5620_RS14790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K5620_RS14795	COG1381	Involved in DNA repair and RecF pathway recombination
K5620_RS14800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5620_RS14805	COG0571	ribonuclease III activity
K5620_RS14815	COG0481	GTPase activity
K5620_RS14820	COG3086	response to oxidative stress
K5620_RS14825	COG3026	antisigma factor binding
K5620_RS14835	COG1595	DNA-templated transcription, initiation
K5620_RS14840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K5620_RS14850	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K5620_RS14865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5620_RS14870	COG0581	inorganic phosphate transmembrane transporter activity
K5620_RS14875	COG0573	inorganic phosphate transmembrane transporter activity
K5620_RS14880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5620_RS14885	COG3108	Peptidase M15
K5620_RS14890	COG2989	Protein conserved in bacteria
K5620_RS14915	COG0681	Belongs to the peptidase S26 family
K5620_RS14920	COG0655	NAD(P)H dehydrogenase (quinone) activity
K5620_RS14955	COG0039	L-malate dehydrogenase activity
K5620_RS14975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5620_RS14980	COG4232	protein-disulfide reductase activity
K5620_RS14995	COG0840	transmembrane signaling receptor activity
K5620_RS15010	COG0668	transmembrane transport
K5620_RS15015	COG0387	Pfam Sodium calcium exchanger
K5620_RS15020	COG0586	Pfam SNARE associated Golgi protein
K5620_RS15025	COG0583	DNA-binding transcription factor activity
K5620_RS15040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5620_RS15045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5620_RS15055	COG0598	Magnesium transport protein CorA
K5620_RS15080	COG2304	oxidoreductase activity
K5620_RS15090	COG0840	transmembrane signaling receptor activity
K5620_RS15095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5620_RS15135	COG0625	glutathione transferase activity
K5620_RS15145	COG2133	pyrroloquinoline quinone binding
K5620_RS15165	COG1028	Short-chain dehydrogenase reductase Sdr
K5620_RS15165	COG0604	alcohol dehydrogenase
K5620_RS15165	COG3321	synthase
K5620_RS15205	COG2207	Transcriptional regulator
K5620_RS15225	COG1132	(ABC) transporter
K5620_RS15265	COG1042	CoA-binding domain protein
K5620_RS15265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5620_RS15265	COG0045	succinate-CoA ligase (ADP-forming) activity
K5620_RS15280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5620_RS15280	COG0301	tRNA thio-modification
K5620_RS15285	COG1360	Flagellar Motor Protein
K5620_RS15290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K5620_RS15300	COG0142	geranyltranstransferase activity
K5620_RS15305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K5620_RS15310	COG4166	transmembrane transport
K5620_RS15315	COG4608	Belongs to the ABC transporter superfamily
K5620_RS15320	COG0444	Belongs to the ABC transporter superfamily
K5620_RS15325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5620_RS15330	COG0601	transmembrane transport
K5620_RS15335	COG0747	negative chemotaxis
K5620_RS15340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K5620_RS15345	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K5620_RS15350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5620_RS15355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K5620_RS15370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5620_RS15370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5620_RS15375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5620_RS15380	COG0693	protein deglycase activity
K5620_RS15405	COG1376	ErfK ybiS ycfS ynhG family protein
K5620_RS15405	COG1388	LysM domain
K5620_RS15410	COG0488	(ABC) transporter
K5620_RS15430	COG3040	lipid binding
K5620_RS15435	COG0730	response to heat
K5620_RS15440	COG0579	oxidoreductase
K5620_RS15445	COG0678	peroxiredoxin activity
K5620_RS15470	COG1595	DNA-templated transcription, initiation
K5620_RS15480	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K5620_RS15490	COG2996	Protein conserved in bacteria
K5620_RS15505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5620_RS15520	COG3916	Acyl-homoserine-lactone synthase
K5620_RS15530	COG2197	response regulator
K5620_RS15535	COG2860	membrane
K5620_RS15540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5620_RS15545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K5620_RS15550	COG0494	nUDIX hydrolase
K5620_RS15560	COG3005	denitrification pathway
K5620_RS15575	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K5620_RS15580	COG2199	diguanylate cyclase activity
K5620_RS15580	COG2200	EAL domain
K5620_RS15585	COG0243	molybdopterin cofactor binding
K5620_RS15595	COG0328	RNA-DNA hybrid ribonuclease activity
K5620_RS15600	COG0583	DNA-binding transcription factor activity
K5620_RS15605	COG0300	oxidoreductase activity
K5620_RS15625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K5620_RS15665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5620_RS15675	COG2814	Major facilitator Superfamily
K5620_RS15680	COG0583	DNA-binding transcription factor activity
K5620_RS15685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5620_RS15700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5620_RS15710	COG2233	PERMEase
K5620_RS15735	COG1280	lysine exporter protein (LysE YggA)
K5620_RS15740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5620_RS15745	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K5620_RS15765	COG0702	epimerase
K5620_RS15775	COG4143	(ABC) transporter
K5620_RS15785	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K5620_RS15810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5620_RS15820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K5620_RS15825	COG0297	glycogen (starch) synthase activity
K5620_RS15840	COG0697	spore germination
K5620_RS15870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K5620_RS15880	COG2154	pterin-4-alpha-carbinolamine dehydratase
K5620_RS15895	COG1573	uracil-dna glycosylase
K5620_RS15900	COG0667	Aldo Keto reductase
K5620_RS15915	COG2193	ferroxidase activity
K5620_RS15925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5620_RS15930	COG3135	benzoate transporter
K5620_RS15935	COG1396	sequence-specific DNA binding
K5620_RS15945	COG0735	belongs to the Fur family
K5620_RS15950	COG0739	heme binding
K5620_RS15965	COG0129	dihydroxy-acid dehydratase activity
K5620_RS15970	COG3265	gluconokinase activity
K5620_RS15975	COG3459	Glycosyltransferase 36 associated
K5620_RS15980	COG1609	Transcriptional regulator
K5620_RS15990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5620_RS16005	COG0517	IMP dehydrogenase activity
K5620_RS16020	COG0708	Exodeoxyribonuclease III
K5620_RS16025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5620_RS16040	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K5620_RS16100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5620_RS16130	COG0748	coenzyme F420 binding
K5620_RS16135	COG3721	Heme iron utilization protein
K5620_RS16140	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K5620_RS16145	COG0811	peptide transport
K5620_RS16150	COG0848	biopolymer transport protein
K5620_RS16160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5620_RS16180	COG2267	carboxylic ester hydrolase activity
K5620_RS16195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K5620_RS16225	COG3487	Iron-regulated protein
K5620_RS16235	COG0251	oxidation-reduction process
K5620_RS16255	COG0840	transmembrane signaling receptor activity
K5620_RS16275	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K5620_RS16315	COG3386	PFAM SMP-30 Gluconolaconase
K5620_RS16340	COG0583	DNA-binding transcription factor activity
K5620_RS16350	COG0667	Aldo Keto reductase
K5620_RS16355	COG5002	protein histidine kinase activity
K5620_RS16355	COG5001	Diguanylate cyclase
K5620_RS16380	COG1183	phosphatidylcholine synthase activity
K5620_RS16390	COG0542	response to heat
K5620_RS16395	COG1496	oxidoreductase activity
K5620_RS16405	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5620_RS16450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K5620_RS16455	COG1047	Peptidyl-prolyl cis-trans
K5620_RS16465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5620_RS16470	COG0196	riboflavin kinase activity
K5620_RS16475	COG0728	peptidoglycan biosynthetic process
K5620_RS16480	COG0268	Binds directly to 16S ribosomal RNA
K5620_RS16485	COG0640	Transcriptional regulator
K5620_RS16495	COG0583	DNA-binding transcription factor activity
K5620_RS16500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K5620_RS16505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K5620_RS16510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5620_RS16520	COG0494	nUDIX hydrolase
K5620_RS16525	COG3066	DNA modification
K5620_RS16535	COG0335	large ribosomal subunit rRNA binding
K5620_RS16540	COG0336	Belongs to the RNA methyltransferase TrmD family
K5620_RS16545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5620_RS16550	COG0228	four-way junction DNA binding
K5620_RS16555	COG1011	Hydrolase
K5620_RS16560	COG3036	rescue of stalled ribosome
K5620_RS16600	COG0784	Response regulator, receiver
K5620_RS16600	COG2205	protein histidine kinase activity
K5620_RS16640	COG0395	ABC-type sugar transport system, permease component
K5620_RS16650	COG3842	ATPase activity
K5620_RS16655	COG3842	ATPase activity
K5620_RS16660	COG3284	Transcriptional regulator
K5620_RS16680	COG1028	Short-chain dehydrogenase reductase Sdr
K5620_RS16695	COG0840	transmembrane signaling receptor activity
K5620_RS16700	COG3118	belongs to the thioredoxin family
K5620_RS16705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K5620_RS16710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5620_RS16715	COG4974	Belongs to the 'phage' integrase family
K5620_RS16720	COG0716	FMN binding
K5620_RS16725	COG0840	transmembrane signaling receptor activity
K5620_RS16735	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K5620_RS16740	COG0513	Belongs to the DEAD box helicase family
K5620_RS16755	COG3022	response to hydroperoxide
K5620_RS16770	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K5620_RS16775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5620_RS16780	COG0762	integral membrane protein
K5620_RS16795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K5620_RS16800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5620_RS16805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5620_RS16810	COG3813	Protein conserved in bacteria
K5620_RS16830	COG1522	sequence-specific DNA binding
K5620_RS16835	COG1194	a g-specific adenine glycosylase
K5620_RS16840	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K5620_RS16895	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K5620_RS16900	COG0583	DNA-binding transcription factor activity
K5620_RS16940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5620_RS16945	COG3314	Sporulation integral membrane protein YlbJ
K5620_RS16970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K5620_RS16980	COG0560	Phosphoserine phosphatase
K5620_RS16990	COG0813	purine-nucleoside phosphorylase activity
K5620_RS16995	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K5620_RS17000	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K5620_RS17005	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K5620_RS17010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K5620_RS17025	COG0084	hydrolase, TatD family'
K5620_RS17030	COG1744	ABC transporter substrate-binding protein PnrA-like
K5620_RS17035	COG3845	ABC transporter
K5620_RS17040	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5620_RS17045	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5620_RS17050	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K5620_RS17085	COG0786	glutamate:sodium symporter activity
K5620_RS17090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5620_RS17105	COG0583	DNA-binding transcription factor activity
K5620_RS17130	COG0628	permease
K5620_RS17135	COG1501	Belongs to the glycosyl hydrolase 31 family
K5620_RS17140	COG0583	DNA-binding transcription factor activity
K5620_RS17220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5620_RS17265	COG0778	Nitroreductase
K5620_RS17280	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K5620_RS17280	COG0167	dihydroorotate dehydrogenase activity
K5620_RS17285	COG0493	'glutamate synthase
K5620_RS17290	COG1309	transcriptional regulator
K5620_RS17310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5620_RS17315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5620_RS17320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5620_RS17335	COG0840	transmembrane signaling receptor activity
K5620_RS17380	COG4166	transmembrane transport
K5620_RS17395	COG0444	Belongs to the ABC transporter superfamily
K5620_RS17400	COG4608	Belongs to the ABC transporter superfamily
K5620_RS17415	COG1609	Transcriptional regulator
K5620_RS17455	COG0795	lipopolysaccharide-transporting ATPase activity
K5620_RS17460	COG0795	lipopolysaccharide-transporting ATPase activity
K5620_RS17465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K5620_RS17470	COG2927	DNA polymerase III (CHI subunit)
K5620_RS17475	COG0525	valine-tRNA ligase activity
K5620_RS17490	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
K5620_RS17495	COG0204	Acyl-transferase
K5620_RS17505	COG5001	Diguanylate cyclase
K5620_RS17505	COG5002	protein histidine kinase activity
K5620_RS17510	COG0187	DNA topoisomerase II activity
K5620_RS17515	COG3150	esterase
K5620_RS17525	COG3151	Protein conserved in bacteria
K5620_RS17530	COG0494	nUDIX hydrolase
K5620_RS17535	COG1538	Outer membrane efflux protein
K5620_RS17540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5620_RS17540	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K5620_RS17545	COG1560	Kdo2-lipid A biosynthetic process
K5620_RS17550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K5620_RS17555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5620_RS17570	COG1392	Phosphate transport regulator
K5620_RS17575	COG0306	phosphate transporter
K5620_RS17590	COG3409	Peptidoglycan-binding domain 1 protein
K5620_RS17590	COG3267	Type II secretory pathway component ExeA
K5620_RS17595	COG0617	tRNA 3'-terminal CCA addition
K5620_RS17610	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K5620_RS17615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K5620_RS17620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5620_RS17630	COG1610	YqeY-like protein
K5620_RS17635	COG0358	DNA primase activity
K5620_RS17660	COG0537	adenosine 5'-monophosphoramidase activity
K5620_RS17695	COG1278	Cold shock
K5620_RS17815	COG0697	spore germination
K5620_RS17860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5620_RS17875	COG2116	formate transmembrane transporter activity
K5620_RS17880	COG0583	DNA-binding transcription factor activity
K5620_RS17885	COG0297	glycogen (starch) synthase activity
K5620_RS17890	COG0438	transferase activity, transferring glycosyl groups
K5620_RS17910	COG3038	cytochrome b561
K5620_RS17935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K5620_RS17970	COG1584	GPR1 FUN34 yaaH family protein
K5620_RS17995	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K5620_RS18010	COG2431	L-lysine efflux transmembrane transporter activity
K5620_RS18015	COG0784	Response regulator, receiver
K5620_RS18015	COG2198	Histidine kinase
K5620_RS18015	COG5002	protein histidine kinase activity
K5620_RS18020	COG1469	GTP cyclohydrolase I activity
K5620_RS18025	COG2203	Gaf domain
K5620_RS18025	COG3706	GGDEF domain
K5620_RS18025	COG4251	negative regulation of phosphorylation
K5620_RS18025	COG5001	Diguanylate cyclase
K5620_RS18030	COG1242	4 iron, 4 sulfur cluster binding
K5620_RS18040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K5620_RS18050	COG1012	belongs to the aldehyde dehydrogenase family
K5620_RS18065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5620_RS18080	COG0739	heme binding
K5620_RS18085	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K5620_RS18110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K5620_RS18120	COG2832	Protein of unknown function (DUF454)
K5620_RS18150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5620_RS18180	COG1643	Atp-dependent helicase
K5620_RS18185	COG1489	DNA binding
K5620_RS18190	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K5620_RS18195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5620_RS18205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K5620_RS18210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K5620_RS18215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K5620_RS18220	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K5620_RS18245	COG0842	Transport permease protein
K5620_RS18250	COG1131	(ABC) transporter
K5620_RS18265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5620_RS18285	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K5620_RS18305	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K5620_RS18320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K5620_RS18325	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K5620_RS18335	COG1607	acyl-coa hydrolase
K5620_RS18340	COG2204	response regulator
K5620_RS18350	COG3267	Type II secretory pathway component ExeA
K5620_RS18350	COG3409	Peptidoglycan-binding domain 1 protein
K5620_RS18360	COG0489	protein tyrosine kinase activity
K5620_RS18375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5620_RS18390	COG0726	polysaccharide deacetylase
K5620_RS18405	COG1045	serine acetyltransferase
K5620_RS18420	COG0297	glycogen (starch) synthase activity
K5620_RS18420	COG0438	transferase activity, transferring glycosyl groups
K5620_RS18435	COG2244	polysaccharide biosynthetic process
K5620_RS18440	COG1215	transferase activity, transferring glycosyl groups
K5620_RS18465	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K5620_RS18500	COG0629	single-stranded DNA binding
K5620_RS18505	COG2814	Major facilitator Superfamily
K5620_RS18510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5620_RS18540	COG0791	NLP P60 protein
K5620_RS18545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K5620_RS18550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K5620_RS18560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5620_RS18575	COG0429	hydrolase of the alpha beta-hydrolase fold
K5620_RS18580	COG3089	Belongs to the UPF0270 family
K5620_RS18585	COG3954	Phosphoribulokinase
K5620_RS18590	COG1765	OsmC-like protein
K5620_RS18605	COG1012	belongs to the aldehyde dehydrogenase family
K5620_RS18615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K5620_RS18640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5620_RS18650	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K5620_RS18660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K5620_RS18665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5620_RS18695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K5620_RS18710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5620_RS18715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5620_RS18720	COG0049	tRNA binding
K5620_RS18725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5620_RS18735	COG2923	Belongs to the DsrF TusC family
K5620_RS18740	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K5620_RS18745	COG0251	oxidation-reduction process
K5620_RS18750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5620_RS18755	COG0085	RNA polymerase activity
K5620_RS18760	COG0222	ribosome binding
K5620_RS18765	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5620_RS18775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5620_RS18780	COG0250	Participates in transcription elongation, termination and antitermination
K5620_RS18785	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5620_RS18795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5620_RS18800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5620_RS18805	COG0049	tRNA binding
K5620_RS18810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5620_RS18820	COG2923	Belongs to the DsrF TusC family
K5620_RS18825	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K5620_RS18830	COG0251	oxidation-reduction process
K5620_RS18835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5620_RS18840	COG0085	RNA polymerase activity
K5620_RS18845	COG0222	ribosome binding
K5620_RS18850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5620_RS18860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5620_RS18865	COG0250	Participates in transcription elongation, termination and antitermination
K5620_RS18870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5620_RS18880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5620_RS18905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K5620_RS18905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K5620_RS18910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5620_RS18915	COG1072	(Pantothenic acid kinase))
K5620_RS18920	COG0489	protein tyrosine kinase activity
K5620_RS18920	COG3206	protein involved in exopolysaccharide biosynthesis
K5620_RS18925	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5620_RS18930	COG0255	Belongs to the universal ribosomal protein uL29 family
K5620_RS18935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5620_RS18940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5620_RS18945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5620_RS18950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5620_RS18955	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5620_RS18960	COG0089	rRNA binding
K5620_RS18965	COG0088	Forms part of the polypeptide exit tunnel
K5620_RS18970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5620_RS18975	COG0051	transcription antitermination factor activity, RNA binding
K5620_RS18980	COG5002	protein histidine kinase activity
K5620_RS18990	COG2315	Protein conserved in bacteria
K5620_RS19005	COG0137	argininosuccinate synthase activity
K5620_RS19015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K5620_RS19025	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K5620_RS19045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K5620_RS19050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5620_RS19055	COG1609	Transcriptional regulator
K5620_RS19060	COG5297	Belongs to the glycosyl hydrolase family 6
K5620_RS19060	COG2273	Hydrolase Family 16
K5620_RS19065	COG2183	response to ionizing radiation
K5620_RS19080	COG0596	Alpha beta hydrolase
K5620_RS19090	COG0316	Belongs to the HesB IscA family
K5620_RS19090	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K5620_RS19095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5620_RS19100	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K5620_RS19105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5620_RS19110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K5620_RS19115	COG4942	peptidase
K5620_RS19175	COG1494	fructose-1,6-bisphosphatase
K5620_RS19185	COG0686	Belongs to the AlaDH PNT family
K5620_RS19200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K5620_RS19200	COG1648	precorrin-2 dehydrogenase activity
K5620_RS19205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K5620_RS19205	COG2146	nitrite reductase [NAD(P)H] activity
K5620_RS19215	COG2223	nitrite transmembrane transporter activity
K5620_RS19220	COG0515	serine threonine protein kinase
K5620_RS19220	COG2815	serine threonine protein kinase
K5620_RS19235	COG2177	Part of the ABC transporter FtsEX involved in
K5620_RS19240	COG2884	Cell division ATP-binding protein ftsE
K5620_RS19245	COG0552	protein localization to endoplasmic reticulum
K5620_RS19250	COG0742	ribosomal rna small subunit methyltransferase
K5620_RS19265	COG2095	MarC family integral membrane protein
K5620_RS19300	COG0004	ammonium transporteR
K5620_RS19305	COG0248	Ppx GppA phosphatase
K5620_RS19330	COG2770	Histidine kinase
K5620_RS19330	COG3437	response regulator, receiver
K5620_RS19335	COG0494	nUDIX hydrolase
K5620_RS19350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5620_RS19355	COG1074	ATP-dependent DNA helicase activity
K5620_RS19360	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K5620_RS19370	COG0606	chelatase, subunit chli
K5620_RS19375	COG0517	IMP dehydrogenase activity
K5620_RS19375	COG0516	GMP reductase activity
K5620_RS19395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5620_RS19400	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
K5620_RS19405	COG4521	taurine ABC transporter
K5620_RS19415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5620_RS19420	COG4221	oxidoreductase activity
K5620_RS19425	COG0686	Belongs to the AlaDH PNT family
K5620_RS19430	COG0110	maltose O-acetyltransferase activity
K5620_RS19445	COG3978	acetolactate synthase activity
K5620_RS19450	COG0129	dihydroxy-acid dehydratase activity
K5620_RS19470	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K5620_RS19475	COG0366	Alpha amylase catalytic
K5620_RS19500	COG0454	-acetyltransferase
K5620_RS19530	COG1472	Belongs to the glycosyl hydrolase 3 family
K5620_RS19540	COG4682	membrane
K5620_RS19580	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K5620_RS19595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K5620_RS19605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5620_RS19610	COG1929	Belongs to the glycerate kinase type-1 family
K5620_RS19620	COG1279	arginine transmembrane transporter activity
K5620_RS19640	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K5620_RS19645	COG1609	Transcriptional regulator
K5620_RS19665	COG0395	ABC-type sugar transport system, permease component
K5620_RS19680	COG3842	ATPase activity
K5620_RS19730	COG2960	long-chain fatty acid transporting porin activity
K5620_RS19740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5620_RS19750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K5620_RS19790	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
K5620_RS19795	COG4335	DNA alkylation repair
K5620_RS19820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K5620_RS19830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5620_RS19835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5620_RS19840	COG1309	transcriptional regulator
K5620_RS19845	COG0210	DNA helicase
K5620_RS19855	COG0366	Alpha amylase catalytic
K5620_RS19855	COG1874	Beta-galactosidase
K5620_RS19860	COG1523	belongs to the glycosyl hydrolase 13 family
K5620_RS19870	COG1846	Transcriptional regulator
K5620_RS19870	COG1940	carbohydrate kinase activity
K5620_RS19880	COG2391	methyltransferase activity
K5620_RS19900	COG0366	Alpha amylase catalytic
K5620_RS19915	COG4977	sequence-specific DNA binding
K5620_RS19915	COG1917	Cupin 2, conserved barrel domain protein
K5620_RS19930	COG0443	Heat shock 70 kDa protein
K5620_RS19945	COG1132	(ABC) transporter
K5620_RS19970	COG0189	ligase activity
K5620_RS19985	COG0189	ligase activity
K5620_RS19985	COG4067	protein conserved in archaea
K5620_RS19990	COG2239	Acts as a magnesium transporter
K5620_RS19995	COG0598	Magnesium transport protein CorA
K5620_RS20025	COG3226	Transcriptional regulator
K5620_RS20030	COG2988	succinylglutamate desuccinylase activity
K5620_RS20035	COG1609	Transcriptional regulator
K5620_RS20035	COG2207	Transcriptional regulator
K5620_RS20040	COG1070	Carbohydrate kinase
K5620_RS20045	COG1609	Transcriptional regulator
K5620_RS20045	COG2207	Transcriptional regulator
K5620_RS20055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K5620_RS20065	COG2115	Belongs to the xylose isomerase family
K5620_RS20075	COG1793	dna ligase
K5620_RS20105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K5620_RS20110	COG0352	thiamine-phosphate diphosphorylase activity
K5620_RS20115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K5620_RS20130	COG1575	Belongs to the MenA family. Type 1 subfamily
K5620_RS20135	COG1169	isochorismate synthase
K5620_RS20140	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K5620_RS20150	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K5620_RS20160	COG4213	ABC transporter substrate-binding protein
K5620_RS20165	COG1129	ABC transporter
K5620_RS20170	COG4214	carbohydrate transport
K5620_RS20185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5620_RS20195	COG3152	Membrane
K5620_RS20200	COG1119	ATPase activity
K5620_RS20245	COG4251	negative regulation of phosphorylation
K5620_RS20245	COG5001	Diguanylate cyclase
K5620_RS20245	COG2203	Gaf domain
K5620_RS20245	COG3706	GGDEF domain
K5620_RS20255	COG2814	Major facilitator Superfamily
K5620_RS20265	COG3263	regulation of cellular component size
K5620_RS20275	COG0840	transmembrane signaling receptor activity
K5620_RS20280	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K5620_RS20295	COG1272	protein, Hemolysin III
K5620_RS20320	COG2197	response regulator
K5620_RS20350	COG0411	ABC transporter
K5620_RS20370	COG0829	nickel cation binding
K5620_RS20375	COG0831	urea catabolic process
K5620_RS20380	COG0832	Belongs to the urease beta subunit family
K5620_RS20385	COG0804	urea catabolic process
K5620_RS20395	COG0830	nickel cation binding
K5620_RS20410	COG0318	PFAM AMP-dependent synthetase and ligase
K5620_RS20440	COG4459	periplasmic nitrate reductase
K5620_RS20445	COG3005	denitrification pathway
K5620_RS20450	COG0243	molybdopterin cofactor binding
K5620_RS20460	COG0281	malic enzyme
K5620_RS20465	COG0840	transmembrane signaling receptor activity
K5620_RS20480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K5620_RS20515	COG1404	Belongs to the peptidase S8 family
K5620_RS20555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K5620_RS20565	COG2153	protein acetylation
K5620_RS20570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5620_RS20575	COG3085	chromosome segregation
K5620_RS20580	COG0408	coproporphyrinogen oxidase activity
K5620_RS20590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5620_RS20595	COG1121	(ABC) transporter
K5620_RS20600	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K5620_RS20605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5620_RS20615	COG3078	GTPase activator activity
K5620_RS20630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K5620_RS20640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5620_RS20640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5620_RS20650	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K5620_RS20655	COG0514	ATP-dependent DNA helicase (RecQ)
K5620_RS20660	COG2050	protein possibly involved in aromatic compounds catabolism
K5620_RS20670	COG2962	Rard protein
K5620_RS20675	COG0210	DNA helicase
K5620_RS20680	COG1011	Hydrolase
K5620_RS20695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K5620_RS20700	COG0019	diaminopimelate decarboxylase activity
K5620_RS20715	COG3072	Adenylate cyclase
K5620_RS20720	COG0181	hydroxymethylbilane synthase activity
K5620_RS20735	COG3071	HemY protein
K5620_RS20750	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K5620_RS20765	COG3118	belongs to the thioredoxin family
K5620_RS20770	COG0513	Belongs to the DEAD box helicase family
K5620_RS20775	COG0248	Ppx GppA phosphatase
K5620_RS20785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5620_RS20790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5620_RS20795	COG3706	GGDEF domain
K5620_RS20820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5620_RS20825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K5620_RS20845	COG1136	(ABC) transporter
K5620_RS20845	COG0577	efflux transmembrane transporter activity
K5620_RS20875	COG0784	Response regulator, receiver
K5620_RS20875	COG0835	chemotaxis
K5620_RS20880	COG0583	DNA-binding transcription factor activity
K5620_RS20890	COG2130	NADP-dependent
K5620_RS20900	COG3842	ATPase activity
K5620_RS20910	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5620_RS20915	COG1177	transmembrane transport
K5620_RS20920	COG0678	peroxiredoxin activity
K5620_RS20920	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5620_RS20925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5620_RS20930	COG5001	Diguanylate cyclase
K5620_RS20930	COG5002	protein histidine kinase activity
K5620_RS20935	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5620_RS20940	COG2153	protein acetylation
K5620_RS20945	COG0742	ribosomal rna small subunit methyltransferase
K5620_RS20950	COG5001	Diguanylate cyclase
K5620_RS20950	COG5002	protein histidine kinase activity
K5620_RS20955	COG0726	polysaccharide deacetylase
K5620_RS20980	COG1215	transferase activity, transferring glycosyl groups
K5620_RS20980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5620_RS20995	COG1063	alcohol dehydrogenase
K5620_RS21005	COG1309	transcriptional regulator
K5620_RS21010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5620_RS21020	COG0463	Glycosyl transferase, family 2
K5620_RS21035	COG1519	Transferase
K5620_RS21040	COG3642	lipopolysaccharide core region biosynthetic process
K5620_RS21045	COG0859	PFAM glycosyl transferase family 9
K5620_RS21050	COG0463	Glycosyl transferase, family 2
K5620_RS21060	COG0859	PFAM glycosyl transferase family 9
K5620_RS21065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5620_RS21070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5620_RS21080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5620_RS21085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5620_RS21090	COG2003	Belongs to the UPF0758 family
K5620_RS21095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5620_RS21100	COG0756	dUTP diphosphatase activity
K5620_RS21105	COG1309	transcriptional regulator
K5620_RS21110	COG0668	transmembrane transport
K5620_RS21130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K5620_RS21135	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5620_RS21140	COG1561	YicC-like family, N-terminal region
K5620_RS21150	COG5632	N-Acetylmuramoyl-L-alanine amidase
K5620_RS21150	COG3409	Peptidoglycan-binding domain 1 protein
K5620_RS21165	COG2356	endonuclease I
K5620_RS21185	COG0668	transmembrane transport
K5620_RS21195	COG0673	inositol 2-dehydrogenase activity
K5620_RS21225	COG3395	kinase activity
K5620_RS21230	COG0235	Class ii aldolase
K5620_RS21240	COG3214	Protein conserved in bacteria
K5620_RS21280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K5620_RS21285	COG1349	DNA-binding transcription factor activity
K5620_RS21310	COG4807	Protein conserved in bacteria
K5620_RS21320	COG0435	Glutathione S-transferase
K5620_RS21325	COG1741	Belongs to the pirin family
K5620_RS21330	COG2259	Doxx family
K5620_RS21335	COG0583	DNA-binding transcription factor activity
K5620_RS21355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5620_RS21375	COG0194	GDP metabolic process
K5620_RS21380	COG1758	RNA polymerase activity
K5620_RS21385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5620_RS21390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5620_RS21395	COG0840	transmembrane signaling receptor activity
K5620_RS21410	COG0204	Acyl-transferase
K5620_RS21425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5620_RS21435	COG2954	triphosphatase activity
K5620_RS21440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K5620_RS21455	COG3084	Protein conserved in bacteria
K5620_RS21460	COG5001	Diguanylate cyclase
K5620_RS21460	COG2203	Gaf domain
K5620_RS21460	COG3706	GGDEF domain
K5620_RS21460	COG4251	negative regulation of phosphorylation
K5620_RS21470	COG0110	maltose O-acetyltransferase activity
K5620_RS21475	COG0417	DNA replication proofreading
K5620_RS21500	COG0534	Mate efflux family protein
K5620_RS21505	COG2860	membrane
K5620_RS21510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5620_RS21515	COG0469	pyruvate kinase activity
K5620_RS21525	COG0668	transmembrane transport
K5620_RS21535	COG0133	tryptophan synthase activity
K5620_RS21540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K5620_RS21545	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K5620_RS21555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5620_RS21560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5620_RS21565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5620_RS21570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5620_RS21575	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5620_RS21580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5620_RS21590	COG0356	it plays a direct role in the translocation of protons across the membrane
K5620_RS21600	COG1475	DNA binding
K5620_RS21605	COG1192	Involved in chromosome partitioning
K5620_RS21610	COG0357	Ribosomal RNA small subunit methyltransferase G
K5620_RS21620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K5620_RS21635	COG1294	oxidase, subunit
K5620_RS21640	COG1271	oxidase subunit
K5620_RS21650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K5620_RS21655	COG0706	membrane insertase activity
K5620_RS21660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5620_RS21665	COG0594	ribonuclease P activity
K5620_RS21675	COG1126	abc transporter atp-binding protein
K5620_RS21690	COG0671	phosphoesterase, PA-phosphatase related
K5620_RS21700	COG2770	Histidine kinase
K5620_RS21700	COG3437	response regulator, receiver
K5620_RS21705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5620_RS21760	COG2885	chlorophyll binding
K5620_RS21760	COG3047	cAMP biosynthetic process