locus-tag	class	description
KO461_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KO461_RS00010	COG0592	DNA-directed DNA polymerase activity
KO461_RS00020	COG2226	methyltransferase
KO461_RS00030	COG2081	HI0933 family
KO461_RS00035	COG3088	subunit of a heme lyase
KO461_RS00035	COG4235	cytochrome complex assembly
KO461_RS00040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO461_RS00045	COG1138	Cytochrome C-type biogenesis protein
KO461_RS00050	COG3301	Polysulphide reductase, NrfD
KO461_RS00055	COG0437	4 iron, 4 sulfur cluster binding
KO461_RS00060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
KO461_RS00095	COG1138	Cytochrome C-type biogenesis protein
KO461_RS00105	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KO461_RS00110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KO461_RS00115	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KO461_RS00120	COG4133	protoheme IX ABC transporter activity
KO461_RS00125	COG2814	Major facilitator Superfamily
KO461_RS00130	COG2814	Major facilitator Superfamily
KO461_RS00175	COG2801	Transposase and inactivated derivatives
KO461_RS00190	COG2267	carboxylic ester hydrolase activity
KO461_RS00195	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KO461_RS00205	COG0436	Aminotransferase
KO461_RS00220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KO461_RS00230	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KO461_RS00235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KO461_RS00245	COG1652	LysM domain
KO461_RS00250	COG2321	neutral zinc metallopeptidase
KO461_RS00265	COG0281	malic enzyme
KO461_RS00265	COG0280	phosphate acetyltransferase
KO461_RS00300	COG2801	Transposase and inactivated derivatives
KO461_RS00305	COG3091	SprT-like family
KO461_RS00310	COG0814	amino acid
KO461_RS00315	COG1760	l-serine dehydratase
KO461_RS00320	COG0252	asparaginase activity
KO461_RS00330	COG3063	Type IV pilus biogenesis stability protein PilW
KO461_RS00335	COG1426	Protein conserved in bacteria
KO461_RS00350	COG2976	Protein conserved in bacteria
KO461_RS00360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KO461_RS00365	COG2233	PERMEase
KO461_RS00370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KO461_RS00375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KO461_RS00380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KO461_RS00390	COG0659	secondary active sulfate transmembrane transporter activity
KO461_RS00410	COG2186	Transcriptional regulator
KO461_RS00425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KO461_RS00435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KO461_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
KO461_RS00450	COG0800	Aldolase
KO461_RS00455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KO461_RS00460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KO461_RS00465	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KO461_RS00470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KO461_RS00480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KO461_RS00485	COG1555	photosystem II stabilization
KO461_RS00495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KO461_RS00515	COG0196	riboflavin kinase activity
KO461_RS00520	COG0728	peptidoglycan biosynthetic process
KO461_RS00535	COG0560	Phosphoserine phosphatase
KO461_RS00545	COG0193	aminoacyl-tRNA hydrolase activity
KO461_RS00550	COG0012	GTP binding
KO461_RS00555	COG1573	uracil-dna glycosylase
KO461_RS00560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KO461_RS00570	COG3115	cell septum assembly
KO461_RS00590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KO461_RS00595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KO461_RS00615	COG0582	viral genome integration into host DNA
KO461_RS00625	COG2801	Transposase and inactivated derivatives
KO461_RS00640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KO461_RS00645	COG0255	Belongs to the universal ribosomal protein uL29 family
KO461_RS00650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KO461_RS00655	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KO461_RS00660	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KO461_RS00665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KO461_RS00670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KO461_RS00675	COG0089	rRNA binding
KO461_RS00680	COG0088	Forms part of the polypeptide exit tunnel
KO461_RS00685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KO461_RS00690	COG0051	transcription antitermination factor activity, RNA binding
KO461_RS00700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KO461_RS00705	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KO461_RS00710	COG2031	fatty acid transporter
KO461_RS00715	COG0183	Belongs to the thiolase family
KO461_RS00725	COG1288	antiporter activity
KO461_RS00730	COG0549	Belongs to the carbamate kinase family
KO461_RS00735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KO461_RS00740	COG0038	chloride channel
KO461_RS00745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KO461_RS00755	COG1522	sequence-specific DNA binding
KO461_RS00760	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KO461_RS00770	COG1393	Belongs to the ArsC family
KO461_RS00780	COG3036	rescue of stalled ribosome
KO461_RS00790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KO461_RS00810	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
KO461_RS00820	COG0569	domain protein
KO461_RS00825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KO461_RS00825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KO461_RS00865	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
KO461_RS00870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KO461_RS00885	COG2960	long-chain fatty acid transporting porin activity
KO461_RS00890	COG3172	ATPase kinase involved in NAD metabolism
KO461_RS00895	COG2129	metallophosphoesterase
KO461_RS00900	COG0814	amino acid
KO461_RS00915	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KO461_RS00935	COG0201	protein transport
KO461_RS00955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KO461_RS00965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KO461_RS00975	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KO461_RS01000	COG0805	protein transport
KO461_RS01005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KO461_RS01010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KO461_RS01040	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KO461_RS01045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KO461_RS01050	COG1011	Hydrolase
KO461_RS01055	COG0494	nUDIX hydrolase
KO461_RS01065	COG3059	membrane
KO461_RS01070	COG1297	OPT oligopeptide transporter protein
KO461_RS01080	COG1218	3'(2'),5'-bisphosphate nucleotidase
KO461_RS01085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KO461_RS01090	COG0363	glucosamine-6-phosphate deaminase activity
KO461_RS01110	COG0762	integral membrane protein
KO461_RS01120	COG0778	Nitroreductase
KO461_RS01140	COG1496	oxidoreductase activity
KO461_RS01155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KO461_RS01175	COG0006	proline dipeptidase activity
KO461_RS01200	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KO461_RS01205	COG1792	Involved in formation and maintenance of cell shape
KO461_RS01210	COG1077	Cell shape determining protein MreB Mrl
KO461_RS01215	COG0557	exoribonuclease II activity
KO461_RS01225	COG2271	Major facilitator Superfamily
KO461_RS01230	COG0584	glycerophosphoryl diester phosphodiesterase
KO461_RS01235	COG0758	DNA mediated transformation
KO461_RS01270	COG1132	(ABC) transporter
KO461_RS01275	COG1917	Cupin 2, conserved barrel domain protein
KO461_RS01275	COG4977	sequence-specific DNA binding
KO461_RS01280	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KO461_RS01285	COG0859	PFAM glycosyl transferase family 9
KO461_RS01300	COG1519	Transferase
KO461_RS01305	COG0463	Glycosyl transferase, family 2
KO461_RS01320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KO461_RS01325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KO461_RS01330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KO461_RS01335	COG3719	Belongs to the RNase T2 family
KO461_RS01345	COG0191	fructose-bisphosphate aldolase activity
KO461_RS01350	COG3307	-O-antigen
KO461_RS01355	COG2267	carboxylic ester hydrolase activity
KO461_RS01360	COG0561	phosphatase activity
KO461_RS01370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KO461_RS01395	COG1072	(Pantothenic acid kinase))
KO461_RS01400	COG0187	DNA topoisomerase II activity
KO461_RS01405	COG0514	ATP-dependent DNA helicase (RecQ)
KO461_RS01420	COG0019	diaminopimelate decarboxylase activity
KO461_RS01425	COG3477	response to acidic pH
KO461_RS01430	COG2818	Glycosylase
KO461_RS01435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KO461_RS01445	COG2195	Cleaves the N-terminal amino acid of tripeptides
KO461_RS01450	COG2801	Transposase and inactivated derivatives
KO461_RS01460	COG0300	oxidoreductase activity
KO461_RS01465	COG1763	Mo-molybdopterin cofactor biosynthetic process
KO461_RS01470	COG3086	response to oxidative stress
KO461_RS01475	COG3026	antisigma factor binding
KO461_RS01480	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
KO461_RS01485	COG1595	DNA-templated transcription, initiation
KO461_RS01500	COG0442	prolyl-tRNA aminoacylation
KO461_RS01505	COG1921	L-seryl-tRNASec selenium transferase activity
KO461_RS01510	COG3276	selenocysteine insertion sequence binding
KO461_RS01580	COG0521	Mo-molybdopterin cofactor biosynthetic process
KO461_RS01585	COG4589	Belongs to the CDS family
KO461_RS01595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KO461_RS01600	COG0471	metal ion transport
KO461_RS01600	COG0490	domain, Protein
KO461_RS01630	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
KO461_RS01645	COG0575	Belongs to the CDS family
KO461_RS01660	COG0233	cytoplasmic translational termination
KO461_RS01675	COG4178	(ABC) transporter
KO461_RS01685	COG1349	DNA-binding transcription factor activity
KO461_RS01690	COG0705	Rhomboid family
KO461_RS01715	COG0551	DNA topoisomerase type I activity
KO461_RS01730	COG2962	Rard protein
KO461_RS01735	COG0583	DNA-binding transcription factor activity
KO461_RS01745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KO461_RS01760	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KO461_RS01765	COG1879	ABC-type sugar transport system periplasmic component
KO461_RS01770	COG1129	ABC transporter
KO461_RS01775	COG1172	Belongs to the binding-protein-dependent transport system permease family
KO461_RS01785	COG2183	response to ionizing radiation
KO461_RS01795	COG2801	Transposase and inactivated derivatives
KO461_RS01800	COG0583	DNA-binding transcription factor activity
KO461_RS01805	COG0471	metal ion transport
KO461_RS01820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KO461_RS01830	COG1595	DNA-templated transcription, initiation
KO461_RS01840	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KO461_RS01845	COG3071	HemY protein
KO461_RS01850	COG2959	enzyme of heme biosynthesis
KO461_RS01860	COG0181	hydroxymethylbilane synthase activity
KO461_RS01870	COG2197	response regulator
KO461_RS01875	COG0729	surface antigen
KO461_RS01880	COG2911	Protein conserved in bacteria
KO461_RS01885	COG0248	Ppx GppA phosphatase
KO461_RS01905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KO461_RS01910	COG3068	Protein conserved in bacteria
KO461_RS01920	COG1349	DNA-binding transcription factor activity
KO461_RS01925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KO461_RS01945	COG2272	Belongs to the type-B carboxylesterase lipase family
KO461_RS01950	COG0667	Aldo Keto reductase
KO461_RS01955	COG0656	L-ascorbic acid biosynthetic process
KO461_RS01970	COG0433	COG0433 Predicted ATPase
KO461_RS01975	COG2258	MOSC domain
KO461_RS01980	COG3012	SEC-C Motif Domain Protein
KO461_RS01990	COG1490	D-aminoacyl-tRNA deacylase activity
KO461_RS01995	COG0786	glutamate:sodium symporter activity
KO461_RS02000	COG2205	protein histidine kinase activity
KO461_RS02005	COG0745	RESPONSE REGULATOR receiver
KO461_RS02010	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KO461_RS02020	COG3082	Protein of unknown function (DUF1414)
KO461_RS02025	COG3083	sulfuric ester hydrolase activity
KO461_RS02030	COG0402	S-adenosylhomocysteine deaminase activity
KO461_RS02035	COG3956	TIGRFAM MazG family protein
KO461_RS02050	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KO461_RS02060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KO461_RS02065	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
KO461_RS02070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KO461_RS02085	COG0148	phosphopyruvate hydratase activity
KO461_RS02095	COG2991	Protein conserved in bacteria
KO461_RS02100	COG1477	protein flavinylation
KO461_RS02105	COG2871	sodium ion transport
KO461_RS02110	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KO461_RS02115	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KO461_RS02120	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KO461_RS02135	COG0271	Belongs to the BolA IbaG family
KO461_RS02140	COG3056	Lipoprotein
KO461_RS02165	COG1194	a g-specific adenine glycosylase
KO461_RS02175	COG3171	Protein conserved in bacteria
KO461_RS02180	COG1840	ABC-type Fe3 transport system, periplasmic component
KO461_RS02185	COG1178	ABC-type Fe3 transport system permease component
KO461_RS02190	COG3842	ATPase activity
KO461_RS02205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KO461_RS02215	COG1561	YicC-like family, N-terminal region
KO461_RS02220	COG0354	folic acid binding
KO461_RS02235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KO461_RS02240	COG1381	Involved in DNA repair and RecF pathway recombination
KO461_RS02245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KO461_RS02250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KO461_RS02255	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KO461_RS02265	COG0500	methyltransferase
KO461_RS02270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KO461_RS02275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KO461_RS02280	COG1309	transcriptional regulator
KO461_RS02285	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KO461_RS02290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KO461_RS02305	COG3306	glycosyltransferase involved in LPS biosynthesis
KO461_RS02315	COG3306	glycosyltransferase involved in LPS biosynthesis
KO461_RS02350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KO461_RS02360	COG1309	transcriptional regulator
KO461_RS02375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KO461_RS02380	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KO461_RS02385	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KO461_RS02390	COG4972	Pilus assembly protein
KO461_RS02410	COG4796	Type ii and iii secretion system protein
KO461_RS02425	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KO461_RS02440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KO461_RS02455	COG0653	protein targeting
KO461_RS02470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KO461_RS02480	COG2801	Transposase and inactivated derivatives
KO461_RS02485	COG0789	Transcriptional regulator
KO461_RS02490	COG4701	Protein of unknown function (DUF721)
KO461_RS02505	COG0494	nUDIX hydrolase
KO461_RS02510	COG1466	dna polymerase III delta subunit
KO461_RS02515	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
KO461_RS02530	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
KO461_RS02535	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
KO461_RS02540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KO461_RS02545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KO461_RS02550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KO461_RS02570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KO461_RS02580	COG4221	oxidoreductase activity
KO461_RS02590	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KO461_RS02595	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KO461_RS02600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KO461_RS02605	COG4137	Cytochrome C assembly protein
KO461_RS02610	COG4536	flavin adenine dinucleotide binding
KO461_RS02615	COG0811	peptide transport
KO461_RS02620	COG0848	biopolymer transport protein
KO461_RS02630	COG4783	chaperone-mediated protein folding
KO461_RS02640	COG0814	amino acid
KO461_RS02665	COG0747	negative chemotaxis
KO461_RS02670	COG2853	Lipoprotein
KO461_RS02685	COG3501	Rhs element vgr protein
KO461_RS02710	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KO461_RS02720	COG2966	Psort location CytoplasmicMembrane, score
KO461_RS02730	COG0545	Peptidyl-prolyl cis-trans isomerase
KO461_RS02735	COG0688	phosphatidylethanolamine metabolic process
KO461_RS02740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KO461_RS02755	COG0500	methyltransferase
KO461_RS02765	COG1399	metal-binding, possibly nucleic acid-binding protein
KO461_RS02775	COG0416	fatty acid biosynthetic process
KO461_RS02785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KO461_RS02790	COG1028	Short-chain dehydrogenase reductase Sdr
KO461_RS02800	COG2814	Major facilitator Superfamily
KO461_RS02805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KO461_RS02810	COG0513	Belongs to the DEAD box helicase family
KO461_RS02815	COG0799	negative regulation of ribosome biogenesis
KO461_RS02825	COG0768	penicillin binding
KO461_RS02830	COG0772	Belongs to the SEDS family
KO461_RS02835	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KO461_RS02835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KO461_RS02840	COG1686	Belongs to the peptidase S11 family
KO461_RS02870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KO461_RS02875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KO461_RS02880	COG0765	amino acid transport
KO461_RS02885	COG1126	abc transporter atp-binding protein
KO461_RS02890	COG2168	tRNA wobble position uridine thiolation
KO461_RS02900	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KO461_RS02905	COG2964	Protein conserved in bacteria
KO461_RS02910	COG0545	Peptidyl-prolyl cis-trans isomerase
KO461_RS02920	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KO461_RS02920	COG0678	peroxiredoxin activity
KO461_RS02925	COG0583	DNA-binding transcription factor activity
KO461_RS02930	COG1309	transcriptional regulator
KO461_RS02935	COG1132	(ABC) transporter
KO461_RS02940	COG4988	ABC transporter
KO461_RS02945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KO461_RS02950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KO461_RS02955	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KO461_RS02965	COG1045	serine acetyltransferase
KO461_RS02975	COG1494	fructose-1,6-bisphosphatase
KO461_RS02985	COG0716	FMN binding
KO461_RS02995	COG0702	epimerase
KO461_RS03000	COG1733	regulation of RNA biosynthetic process
KO461_RS03010	COG3312	ion transport
KO461_RS03030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KO461_RS03040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KO461_RS03055	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KO461_RS03060	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KO461_RS03070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KO461_RS03080	COG1349	DNA-binding transcription factor activity
KO461_RS03120	COG3501	Rhs element vgr protein
KO461_RS03210	COG0459	protein refolding
KO461_RS03215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KO461_RS03225	COG1027	Aspartate ammonia-lyase
KO461_RS03230	COG0859	PFAM glycosyl transferase family 9
KO461_RS03240	COG3716	PTS system mannose fructose sorbose family IID component
KO461_RS03245	COG3715	PTS system
KO461_RS03250	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_RS03250	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO461_RS03255	COG2814	Major facilitator Superfamily
KO461_RS03260	COG2207	Transcriptional regulator
KO461_RS03260	COG1609	Transcriptional regulator
KO461_RS03265	COG1757	Na H antiporter
KO461_RS03275	COG4214	carbohydrate transport
KO461_RS03280	COG1129	ABC transporter
KO461_RS03290	COG2115	Belongs to the xylose isomerase family
KO461_RS03295	COG1070	Carbohydrate kinase
KO461_RS03305	COG0582	viral genome integration into host DNA
KO461_RS03355	COG3561	AntA/AntB antirepressor
KO461_RS03395	COG3070	regulator of competence-specific genes
KO461_RS03400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KO461_RS03410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KO461_RS03415	COG3850	Histidine kinase
KO461_RS03420	COG3062	negative regulation of establishment of protein localization
KO461_RS03425	COG0243	molybdopterin cofactor binding
KO461_RS03430	COG0437	4 iron, 4 sulfur cluster binding
KO461_RS03435	COG0348	domain, Protein
KO461_RS03440	COG3043	anaerobic respiration
KO461_RS03445	COG3005	denitrification pathway
KO461_RS03450	COG0754	glutathionylspermidine amidase activity
KO461_RS03455	COG0859	PFAM glycosyl transferase family 9
KO461_RS03465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO461_RS03475	COG0737	Belongs to the 5'-nucleotidase family
KO461_RS03495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KO461_RS03500	COG1028	Short-chain dehydrogenase reductase Sdr
KO461_RS03510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KO461_RS03565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO461_RS03590	COG1011	Hydrolase
KO461_RS03600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KO461_RS03605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KO461_RS03625	COG1555	photosystem II stabilization
KO461_RS03625	COG1596	polysaccharide export
KO461_RS03630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KO461_RS03635	COG0561	phosphatase activity
KO461_RS03640	COG1040	competence protein
KO461_RS03655	COG1114	Component of the transport system for branched-chain amino acids
KO461_RS03675	COG4804	nuclease activity
KO461_RS03685	COG4545	Glutaredoxin-related protein
KO461_RS03700	COG3381	protein complex oligomerization
KO461_RS03705	COG3302	dmso reductase anchor subunit
KO461_RS03710	COG0437	4 iron, 4 sulfur cluster binding
KO461_RS03725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KO461_RS03725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KO461_RS03735	COG5645	(Lipo)protein
KO461_RS03740	COG0210	DNA helicase
KO461_RS03765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KO461_RS03770	COG0110	maltose O-acetyltransferase activity
KO461_RS03775	COG1238	metal cluster binding
KO461_RS03810	COG2801	Transposase and inactivated derivatives
KO461_RS03860	COG2095	MarC family integral membrane protein
KO461_RS03865	COG0488	(ABC) transporter
KO461_RS03870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KO461_RS03875	COG2137	regulation of response to DNA damage stimulus
KO461_RS03880	COG0251	oxidation-reduction process
KO461_RS03890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KO461_RS03915	COG2826	transposase and inactivated derivatives, IS30 family
KO461_RS03930	COG2801	Transposase and inactivated derivatives
KO461_RS03945	COG0513	Belongs to the DEAD box helicase family
KO461_RS03955	COG3201	nicotinamide mononucleotide transporter
KO461_RS03965	COG3501	Rhs element vgr protein
KO461_RS03970	COG3078	GTPase activator activity
KO461_RS03980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KO461_RS03985	COG0456	acetyltransferase
KO461_RS03995	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KO461_RS04020	COG0511	ligase activity, forming carbon-carbon bonds
KO461_RS04025	COG0439	Biotin carboxylase
KO461_RS04035	COG4783	chaperone-mediated protein folding
KO461_RS04040	COG3924	membrane
KO461_RS04045	COG4145	pantothenate transmembrane transporter activity
KO461_RS04050	COG2184	nucleotidyltransferase activity
KO461_RS04075	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KO461_RS04080	COG1115	amino acid carrier protein
KO461_RS04090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KO461_RS04095	COG0237	dephospho-CoA kinase activity
KO461_RS04095	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KO461_RS04100	COG2801	Transposase and inactivated derivatives
KO461_RS04115	COG2801	Transposase and inactivated derivatives
KO461_RS04140	COG1181	Belongs to the D-alanine--D-alanine ligase family
KO461_RS04140	COG2918	glutathione biosynthetic process
KO461_RS04145	COG2194	sulfuric ester hydrolase activity
KO461_RS04150	COG0740	serine-type endopeptidase activity
KO461_RS04170	COG3739	integral membrane protein
KO461_RS04175	COG2217	Heavy metal translocating P-type atpase
KO461_RS04180	COG2608	mercury ion transmembrane transporter activity
KO461_RS04200	COG2932	Transcriptional regulator
KO461_RS04220	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KO461_RS04240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KO461_RS04290	COG1459	type II secretion system
KO461_RS04300	COG4969	Belongs to the N-Me-Phe pilin family
KO461_RS04305	COG3023	N-Acetylmuramoyl-L-alanine amidase
KO461_RS04310	COG2731	YhcH YjgK YiaL family protein
KO461_RS04320	COG4785	May be involved in cell division
KO461_RS04325	COG0513	Belongs to the DEAD box helicase family
KO461_RS04340	COG3835	regulator
KO461_RS04345	COG2610	gluconate transmembrane transporter activity
KO461_RS04350	COG1929	Belongs to the glycerate kinase type-1 family
KO461_RS04355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KO461_RS04360	COG0312	modulator of DNA gyrase
KO461_RS04365	COG3028	Belongs to the UPF0307 family
KO461_RS04370	COG0471	metal ion transport
KO461_RS04380	COG1575	Belongs to the MenA family. Type 1 subfamily
KO461_RS04385	COG1720	tRNA m6t6A37 methyltransferase activity
KO461_RS04410	COG2177	Part of the ABC transporter FtsEX involved in
KO461_RS04415	COG2884	Cell division ATP-binding protein ftsE
KO461_RS04420	COG0552	protein localization to endoplasmic reticulum
KO461_RS04425	COG0742	ribosomal rna small subunit methyltransferase
KO461_RS04430	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO461_RS04430	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_RS04435	COG3715	PTS system
KO461_RS04440	COG3716	PTS system mannose fructose sorbose family IID component
KO461_RS04445	COG0561	phosphatase activity
KO461_RS04450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KO461_RS04465	COG1649	PFAM Uncharacterised BCR, COG1649
KO461_RS04465	COG0726	polysaccharide deacetylase
KO461_RS04470	COG1215	transferase activity, transferring glycosyl groups
KO461_RS04480	COG2271	Major facilitator Superfamily
KO461_RS04505	COG2801	Transposase and inactivated derivatives
KO461_RS04525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KO461_RS04535	COG1758	RNA polymerase activity
KO461_RS04540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KO461_RS04550	COG3161	chorismate lyase activity
KO461_RS04580	COG2826	transposase and inactivated derivatives, IS30 family
KO461_RS04590	COG2801	Transposase and inactivated derivatives
KO461_RS04650	COG4964	Belongs to the GSP D family
KO461_RS04675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KO461_RS04685	COG1444	tRNA N-acetyltransferase activity
KO461_RS04695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KO461_RS04705	COG1126	abc transporter atp-binding protein
KO461_RS04710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KO461_RS04715	COG4215	(ABC) transporter
KO461_RS04720	COG4160	amino acid transport
KO461_RS04725	COG1966	Carbon starvation protein
KO461_RS04740	COG3116	cell division
KO461_RS04745	COG0768	penicillin binding
KO461_RS04755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KO461_RS04775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KO461_RS04790	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KO461_RS04795	COG0849	cell division
KO461_RS04800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KO461_RS04810	COG1605	Chorismate mutase
KO461_RS04810	COG0077	Prephenate dehydratase
KO461_RS04815	COG0326	Molecular chaperone. Has ATPase activity
KO461_RS04820	COG1393	Belongs to the ArsC family
KO461_RS04830	COG1876	peptidase activity
KO461_RS04835	COG0494	nUDIX hydrolase
KO461_RS04840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KO461_RS04885	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KO461_RS04895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KO461_RS04900	COG1053	succinate dehydrogenase
KO461_RS04910	COG1120	ATPase activity
KO461_RS04915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO461_RS04920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO461_RS04925	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KO461_RS04930	COG1408	metallophosphoesterase
KO461_RS04940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KO461_RS04945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KO461_RS04950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KO461_RS04965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KO461_RS04975	COG0741	lytic transglycosylase activity
KO461_RS04980	COG2350	Protein conserved in bacteria
KO461_RS04985	COG1607	acyl-coa hydrolase
KO461_RS05000	COG3047	cAMP biosynthetic process
KO461_RS05005	COG0497	DNA recombination
KO461_RS05015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KO461_RS05025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KO461_RS05025	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KO461_RS05030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KO461_RS05035	COG0784	Response regulator, receiver
KO461_RS05035	COG2198	Histidine kinase
KO461_RS05035	COG5002	protein histidine kinase activity
KO461_RS05040	COG4211	Belongs to the binding-protein-dependent transport system permease family
KO461_RS05045	COG1129	ABC transporter
KO461_RS05050	COG1879	ABC-type sugar transport system periplasmic component
KO461_RS05055	COG1609	Transcriptional regulator
KO461_RS05060	COG1085	galactose-1-phosphate uridylyltransferase
KO461_RS05070	COG2017	converts alpha-aldose to the beta-anomer
KO461_RS05090	COG0471	metal ion transport
KO461_RS05095	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KO461_RS05095	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
KO461_RS05100	COG3051	citrate lyase alpha subunit
KO461_RS05105	COG2301	Belongs to the HpcH HpaI aldolase family
KO461_RS05115	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
KO461_RS05120	COG4535	Mg2 and Co2 transporter CorC
KO461_RS05140	COG0105	UTP biosynthetic process
KO461_RS05160	COG1388	LysM domain
KO461_RS05160	COG4942	peptidase
KO461_RS05170	COG1238	metal cluster binding
KO461_RS05200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KO461_RS05215	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KO461_RS05235	COG1285	pathogenesis
KO461_RS05250	COG2826	transposase and inactivated derivatives, IS30 family
KO461_RS05295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KO461_RS05295	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KO461_RS05295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KO461_RS05300	COG1105	Belongs to the carbohydrate kinase PfkB family
KO461_RS05305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_RS05305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_RS05315	COG0746	molybdenum cofactor guanylyltransferase activity
KO461_RS05320	COG3084	Protein conserved in bacteria
KO461_RS05325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KO461_RS05330	COG3085	chromosome segregation
KO461_RS05375	COG0561	phosphatase activity
KO461_RS05385	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KO461_RS05395	COG2610	gluconate transmembrane transporter activity
KO461_RS05400	COG3622	Belongs to the hyi family
KO461_RS05405	COG0235	Class ii aldolase
KO461_RS05410	COG3395	kinase activity
KO461_RS05415	COG2084	Dehydrogenase
KO461_RS05420	COG1349	DNA-binding transcription factor activity
KO461_RS05425	COG0347	Belongs to the P(II) protein family
KO461_RS05430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KO461_RS05435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KO461_RS05440	COG0470	DNA polymerase III
KO461_RS05445	COG0084	hydrolase, TatD family'
KO461_RS05455	COG1253	flavin adenine dinucleotide binding
KO461_RS05460	COG3293	Transposase
KO461_RS05480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KO461_RS05485	COG4942	peptidase
KO461_RS05490	COG2861	carbohydrate metabolic process
KO461_RS05540	COG0210	DNA helicase
KO461_RS05570	COG2990	Protein conserved in bacteria
KO461_RS05575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KO461_RS05595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KO461_RS05660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KO461_RS05675	COG0084	hydrolase, TatD family'
KO461_RS05680	COG0602	queuosine metabolic process
KO461_RS05685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KO461_RS05685	COG1328	CTP reductase activity
KO461_RS05695	COG1022	Amp-dependent synthetase and ligase
KO461_RS05700	COG0587	DNA-directed DNA polymerase activity
KO461_RS05720	COG0753	catalase activity
KO461_RS05725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KO461_RS05730	COG0165	Argininosuccinate lyase
KO461_RS05770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KO461_RS05775	COG1879	ABC-type sugar transport system periplasmic component
KO461_RS05780	COG1172	Belongs to the binding-protein-dependent transport system permease family
KO461_RS05790	COG1869	D-ribose catabolic process
KO461_RS05800	COG0730	response to heat
KO461_RS05815	COG0590	tRNA wobble adenosine to inosine editing
KO461_RS05845	COG3501	Rhs element vgr protein
KO461_RS05850	COG0489	protein tyrosine kinase activity
KO461_RS05855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KO461_RS05855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KO461_RS05860	COG2975	iron-sulfur cluster assembly
KO461_RS05865	COG0633	Ferredoxin
KO461_RS05870	COG0443	Heat shock 70 kDa protein
KO461_RS05885	COG0822	iron-sulfur transferase activity
KO461_RS05895	COG1959	2 iron, 2 sulfur cluster binding
KO461_RS05900	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
KO461_RS05955	COG0626	cystathionine gamma-synthase activity
KO461_RS05960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KO461_RS05975	COG1530	ribonuclease E activity
KO461_RS05985	COG2259	Doxx family
KO461_RS05995	COG1611	Belongs to the LOG family
KO461_RS06010	COG0745	RESPONSE REGULATOR receiver
KO461_RS06015	COG4608	Belongs to the ABC transporter superfamily
KO461_RS06020	COG0444	Belongs to the ABC transporter superfamily
KO461_RS06025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KO461_RS06030	COG0601	transmembrane transport
KO461_RS06035	COG4166	transmembrane transport
KO461_RS06045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KO461_RS06050	COG0697	spore germination
KO461_RS06055	COG0697	spore germination
KO461_RS06070	COG0142	geranyltranstransferase activity
KO461_RS06075	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KO461_RS06080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KO461_RS06095	COG2056	Na+-H+ antiporter family
KO461_RS06100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KO461_RS06105	COG0346	lactoylglutathione lyase activity
KO461_RS06115	COG2271	Major facilitator Superfamily
KO461_RS06130	COG1755	Isoprenylcysteine carboxyl methyltransferase
KO461_RS06135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KO461_RS06140	COG2801	Transposase and inactivated derivatives
KO461_RS06155	COG0494	nUDIX hydrolase
KO461_RS06160	COG0217	transcriptional regulatory protein
KO461_RS06190	COG1271	oxidase subunit
KO461_RS06195	COG1294	oxidase, subunit
KO461_RS06210	COG0824	Thioesterase
KO461_RS06215	COG0811	peptide transport
KO461_RS06220	COG0848	biopolymer transport protein
KO461_RS06225	COG3064	Membrane
KO461_RS06255	COG2165	general secretion pathway protein
KO461_RS06260	COG4795	General secretion pathway protein
KO461_RS06275	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KO461_RS06280	COG0456	acetyltransferase
KO461_RS06285	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
KO461_RS06290	COG2813	Specifically methylates the guanine in position
KO461_RS06305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KO461_RS06315	COG2994	toxin metabolic process
KO461_RS06320	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
KO461_RS06325	COG2274	protein secretion by the type I secretion system
KO461_RS06330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KO461_RS06340	COG0246	Mannitol dehydrogenase
KO461_RS06345	COG3722	fumarate hydratase activity
KO461_RS06350	COG0673	inositol 2-dehydrogenase activity
KO461_RS06360	COG3962	Belongs to the TPP enzyme family
KO461_RS06365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KO461_RS06390	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KO461_RS06415	COG3623	hexulose-6-phosphate isomerase
KO461_RS06420	COG0235	Class ii aldolase
KO461_RS06440	COG0814	amino acid
KO461_RS06450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KO461_RS06455	COG0778	Nitroreductase
KO461_RS06475	COG2268	Band 7 protein
KO461_RS06480	COG0114	fumarate hydratase activity
KO461_RS06485	COG2927	DNA polymerase III (CHI subunit)
KO461_RS06505	COG3550	peptidyl-serine autophosphorylation
KO461_RS06520	COG2814	Major facilitator Superfamily
KO461_RS06525	COG1566	PFAM secretion protein HlyD family protein
KO461_RS06530	COG0783	Belongs to the Dps family
KO461_RS06540	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KO461_RS06545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KO461_RS06550	COG0602	queuosine metabolic process
KO461_RS06555	COG0720	synthase
KO461_RS06610	COG1129	ABC transporter
KO461_RS06615	COG1129	ABC transporter
KO461_RS06620	COG1172	Belongs to the binding-protein-dependent transport system permease family
KO461_RS06625	COG1454	alcohol dehydrogenase
KO461_RS06625	COG1012	belongs to the aldehyde dehydrogenase family
KO461_RS06635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KO461_RS06640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KO461_RS06645	COG1862	Preprotein translocase
KO461_RS06655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KO461_RS06710	COG0826	peptidase U32
KO461_RS06725	COG2026	Addiction module toxin, RelE StbE family
KO461_RS06745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KO461_RS06750	COG0328	RNA-DNA hybrid ribonuclease activity
KO461_RS06755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KO461_RS06775	COG1620	l-lactate permease
KO461_RS06795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KO461_RS06800	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KO461_RS06805	COG0617	tRNA 3'-terminal CCA addition
KO461_RS06810	COG4991	sh3 domain protein
KO461_RS06815	COG0306	phosphate transporter
KO461_RS06820	COG1392	Phosphate transport regulator
KO461_RS06825	COG3025	triphosphatase activity
KO461_RS06830	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KO461_RS06835	COG0563	adenylate kinase activity
KO461_RS06840	COG2814	Major facilitator Superfamily
KO461_RS06845	COG0375	protein maturation
KO461_RS06850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KO461_RS06855	COG3152	Membrane
KO461_RS06860	COG2252	PERMEase
KO461_RS06875	COG0825	malonyl-CoA metabolic process
KO461_RS06880	COG2351	hydroxyisourate hydrolase activity
KO461_RS06895	COG3041	Addiction module toxin RelE StbE family
KO461_RS06900	COG3077	Addiction module antitoxin, RelB DinJ family
KO461_RS06905	COG3069	C4-dicarboxylate transmembrane transporter activity
KO461_RS06910	COG2801	Transposase and inactivated derivatives
KO461_RS06925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO461_RS06930	COG0785	Cytochrome C biogenesis protein
KO461_RS06935	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KO461_RS06935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KO461_RS06940	COG0288	reversible hydration of carbon dioxide
KO461_RS06945	COG2823	Periplasmic or secreted lipoprotein
KO461_RS06950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KO461_RS06955	COG0792	nuclease activity
KO461_RS06965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KO461_RS06975	COG1252	NADH dehydrogenase
KO461_RS06985	COG0616	signal peptide processing
KO461_RS06995	COG0625	glutathione transferase activity
KO461_RS07000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KO461_RS07005	COG0187	DNA topoisomerase II activity
KO461_RS07015	COG0488	(ABC) transporter
KO461_RS07020	COG3683	transport system, periplasmic component
KO461_RS07025	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
KO461_RS07045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KO461_RS07050	COG3105	Protein conserved in bacteria
KO461_RS07055	COG1944	ATP diphosphatase activity
KO461_RS07065	COG3422	double-strand break repair
KO461_RS07070	COG2190	(PTS) system
KO461_RS07070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO461_RS07070	COG1263	PTS System
KO461_RS07075	COG2226	methyltransferase
KO461_RS07080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KO461_RS07090	COG1846	Transcriptional regulator
KO461_RS07090	COG1940	carbohydrate kinase activity
KO461_RS07175	COG3501	Rhs element vgr protein
KO461_RS07180	COG2190	(PTS) system
KO461_RS07180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO461_RS07180	COG1263	PTS System
KO461_RS07185	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
KO461_RS07190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KO461_RS07190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KO461_RS07195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KO461_RS07200	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KO461_RS07210	COG1737	Transcriptional regulator
KO461_RS07215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KO461_RS07220	COG0363	glucosamine-6-phosphate deaminase activity
KO461_RS07225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KO461_RS07230	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KO461_RS07245	COG0247	lactate metabolic process
KO461_RS07245	COG0277	FAD linked oxidase domain protein
KO461_RS07265	COG2363	Small membrane protein
KO461_RS07270	COG1643	Atp-dependent helicase
KO461_RS07280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KO461_RS07290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO461_RS07295	COG0577	efflux transmembrane transporter activity
KO461_RS07295	COG1136	(ABC) transporter
KO461_RS07305	COG0577	efflux transmembrane transporter activity
KO461_RS07305	COG1136	(ABC) transporter
KO461_RS07320	COG0672	)-iron permease
KO461_RS07325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KO461_RS07335	COG0316	Belongs to the HesB IscA family
KO461_RS07340	COG0024	Methionine aminopeptidase
KO461_RS07350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KO461_RS07355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KO461_RS07400	COG4172	Belongs to the ABC transporter superfamily
KO461_RS07405	COG4172	Belongs to the ABC transporter superfamily
KO461_RS07410	COG4171	peptide transport system, permease
KO461_RS07415	COG4168	peptide transport system, permease
KO461_RS07420	COG4166	transmembrane transport
KO461_RS07425	COG3106	COG3106 Predicted ATPase
KO461_RS07435	COG3283	Transcriptional regulator of aromatic amino acids metabolism
KO461_RS07440	COG1923	regulation of RNA biosynthetic process
KO461_RS07450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KO461_RS07455	COG1388	LysM domain
KO461_RS07455	COG0860	N-Acetylmuramoyl-L-alanine amidase
KO461_RS07460	COG0802	atpase or kinase
KO461_RS07470	COG2246	polysaccharide biosynthetic process
KO461_RS07480	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KO461_RS07490	COG2194	sulfuric ester hydrolase activity
KO461_RS07525	COG2337	Toxic component of a toxin-antitoxin (TA) module
KO461_RS07540	COG3021	interspecies interaction between organisms
KO461_RS07610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_RS07615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KO461_RS07620	COG2190	(PTS) system
KO461_RS07625	COG0339	signal peptide processing
KO461_RS07630	COG2832	Protein of unknown function (DUF454)
KO461_RS07635	COG4166	transmembrane transport
KO461_RS07655	COG3501	Rhs element vgr protein
KO461_RS07660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KO461_RS07670	COG0512	Glutamine amidotransferase of anthranilate synthase
KO461_RS07675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KO461_RS07695	COG2801	Transposase and inactivated derivatives
KO461_RS07710	COG2932	Transcriptional regulator
KO461_RS07720	COG0517	IMP dehydrogenase activity
KO461_RS07720	COG0516	GMP reductase activity
KO461_RS07725	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KO461_RS07725	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KO461_RS07790	COG0195	Participates in both transcription termination and antitermination
KO461_RS07805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KO461_RS07820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KO461_RS07830	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KO461_RS07835	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
KO461_RS07845	COG3177	Filamentation induced by cAMP protein fic
KO461_RS07855	COG3842	ATPase activity
KO461_RS07860	COG1175	transmembrane transport
KO461_RS07865	COG0395	ABC-type sugar transport system, permease component
KO461_RS07875	COG0322	excinuclease ABC activity
KO461_RS07885	COG2835	tetraacyldisaccharide 4'-kinase activity
KO461_RS07890	COG1663	tetraacyldisaccharide 4'-kinase activity
KO461_RS07895	COG1132	(ABC) transporter
KO461_RS07900	COG2333	competence protein COMEC
KO461_RS07900	COG0658	competence protein
KO461_RS07905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KO461_RS07910	COG0617	tRNA 3'-terminal CCA addition
KO461_RS07915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KO461_RS07925	COG0280	phosphate acetyltransferase
KO461_RS07925	COG0857	belongs to the CobB CobQ family
KO461_RS07930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KO461_RS07935	COG3092	negative regulation of chromosome organization
KO461_RS07940	COG1286	toxin biosynthetic process
KO461_RS07945	COG1640	4-alpha-glucanotransferase
KO461_RS07950	COG0058	SHG alpha-glucan phosphorylase activity
KO461_RS07955	COG2909	trisaccharide binding
KO461_RS07965	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KO461_RS07970	COG0508	dehydrogenase complex catalyzes the overall conversion of
KO461_RS07975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KO461_RS07980	COG0778	Nitroreductase
KO461_RS07985	COG0616	signal peptide processing
KO461_RS07995	COG0009	L-threonylcarbamoyladenylate synthase
KO461_RS08005	COG0583	DNA-binding transcription factor activity
KO461_RS08025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KO461_RS08030	COG2949	membrane
KO461_RS08040	COG3501	Rhs element vgr protein
KO461_RS08060	COG3718	enzyme involved in inositol metabolism
KO461_RS08070	COG2271	Major facilitator Superfamily
KO461_RS08080	COG2801	Transposase and inactivated derivatives
KO461_RS08095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KO461_RS08105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KO461_RS08110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KO461_RS08115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KO461_RS08120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KO461_RS08125	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
KO461_RS08130	COG0310	cobalt ion transport
KO461_RS08135	COG0310	cobalt ion transport
KO461_RS08140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KO461_RS08145	COG1122	ATPase activity
KO461_RS08150	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KO461_RS08155	COG0409	Hydrogenase expression formation protein
KO461_RS08160	COG0309	Hydrogenase expression formation protein (HypE)
KO461_RS08180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KO461_RS08185	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KO461_RS08190	COG0795	lipopolysaccharide-transporting ATPase activity
KO461_RS08195	COG0795	lipopolysaccharide-transporting ATPase activity
KO461_RS08205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KO461_RS08210	COG4149	molybdate abc transporter
KO461_RS08215	COG0725	ABC transporter, periplasmic molybdate-binding protein
KO461_RS08220	COG2005	Transcriptional regulator
KO461_RS08225	COG0471	metal ion transport
KO461_RS08235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KO461_RS08240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KO461_RS08240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KO461_RS08245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KO461_RS08255	COG0583	DNA-binding transcription factor activity
KO461_RS08260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KO461_RS08270	COG0039	L-malate dehydrogenase activity
KO461_RS08275	COG1438	arginine binding
KO461_RS08280	COG1090	epimerase
KO461_RS08285	COG4657	Part of a membrane complex involved in electron transport
KO461_RS08315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KO461_RS08320	COG0733	neurotransmitter:sodium symporter activity
KO461_RS08325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KO461_RS08340	COG0739	heme binding
KO461_RS08345	COG4604	ABC transporter, ATP-binding protein
KO461_RS08350	COG4605	iron ion homeostasis
KO461_RS08355	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO461_RS08360	COG4607	ABC-type enterochelin transport system periplasmic component
KO461_RS08365	COG0737	Belongs to the 5'-nucleotidase family
KO461_RS08385	COG0642	Histidine kinase
KO461_RS08390	COG0405	Gamma-glutamyltransferase
KO461_RS08405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO461_RS08410	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KO461_RS08415	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
KO461_RS08470	COG0583	DNA-binding transcription factor activity
KO461_RS08475	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KO461_RS08480	COG1687	branched-chain amino acid
KO461_RS08485	COG0612	Peptidase, M16
KO461_RS08490	COG4771	TonB-dependent receptor
KO461_RS08495	COG2990	Protein conserved in bacteria
KO461_RS08505	COG0539	negative regulation of cytoplasmic translation
KO461_RS08510	COG0776	regulation of translation
KO461_RS08515	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
KO461_RS08520	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KO461_RS08530	COG0023	Translation Initiation Factor
KO461_RS08535	COG3094	Invasion gene expression up-regulator, SirB
KO461_RS08540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KO461_RS08545	COG0735	belongs to the Fur family
KO461_RS08550	COG0716	FMN binding
KO461_RS08560	COG0596	Alpha beta hydrolase
KO461_RS08565	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
KO461_RS08570	COG0318	PFAM AMP-dependent synthetase and ligase
KO461_RS08575	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KO461_RS08575	COG3264	Mechanosensitive ion channel
KO461_RS08580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KO461_RS08585	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
KO461_RS08590	COG0730	response to heat
KO461_RS08595	COG1560	Kdo2-lipid A biosynthetic process
KO461_RS08605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KO461_RS08615	COG0463	Glycosyl transferase, family 2
KO461_RS08625	COG0251	oxidation-reduction process
KO461_RS08635	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
KO461_RS08640	COG1757	Na H antiporter
KO461_RS08645	COG2916	Histone family protein nucleoid-structuring protein H-NS
KO461_RS08650	COG0788	formyltetrahydrofolate deformylase activity
KO461_RS08660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KO461_RS08665	COG3101	peptidyl-lysine hydroxylation
KO461_RS08670	COG3842	ATPase activity
KO461_RS08675	COG1178	ABC-type Fe3 transport system permease component
KO461_RS08680	COG3842	ATPase activity
KO461_RS08715	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
KO461_RS08720	COG3098	single-species biofilm formation
KO461_RS08735	COG1278	Cold shock
KO461_RS08745	COG1067	ATP-dependent peptidase activity
KO461_RS08750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KO461_RS08760	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KO461_RS08765	COG1074	ATP-dependent DNA helicase activity
KO461_RS08770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KO461_RS08790	COG0101	tRNA pseudouridine synthase activity
KO461_RS08805	COG0471	metal ion transport
KO461_RS08810	COG2315	Protein conserved in bacteria
KO461_RS08815	COG0243	molybdopterin cofactor binding
KO461_RS08820	COG3005	denitrification pathway
KO461_RS08840	COG3293	Transposase
KO461_RS08875	COG1346	cytolysis
KO461_RS08890	COG3657	addiction module killer protein
KO461_RS08895	COG0488	(ABC) transporter
KO461_RS08930	COG3179	chitinase
KO461_RS08950	COG1523	belongs to the glycosyl hydrolase 13 family
KO461_RS08965	COG0058	SHG alpha-glucan phosphorylase activity
KO461_RS08970	COG0586	Pfam SNARE associated Golgi protein
KO461_RS08975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KO461_RS08985	COG1686	Belongs to the peptidase S11 family
KO461_RS08990	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
KO461_RS09000	COG0204	Acyl-transferase
KO461_RS09000	COG0318	PFAM AMP-dependent synthetase and ligase
KO461_RS09005	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
KO461_RS09010	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KO461_RS09015	COG0697	spore germination
KO461_RS09020	COG2925	Exonuclease
KO461_RS09025	COG1528	Iron-storage protein
KO461_RS09030	COG1528	Iron-storage protein
KO461_RS09040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KO461_RS09045	COG0589	response to stress
KO461_RS09050	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
KO461_RS09060	COG0613	PHP domain protein
KO461_RS09065	COG0167	dihydroorotate dehydrogenase activity
KO461_RS09070	COG0308	aminopeptidase N
KO461_RS09075	COG1448	Aminotransferase
KO461_RS09085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KO461_RS09090	COG0842	Transport permease protein
KO461_RS09090	COG1129	ABC transporter
KO461_RS09095	COG0842	Transport permease protein
KO461_RS09110	COG0791	NLP P60 protein
KO461_RS09125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KO461_RS09140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KO461_RS09140	COG0517	IMP dehydrogenase activity
KO461_RS09145	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KO461_RS09150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KO461_RS09160	COG1942	4-Oxalocrotonate Tautomerase
KO461_RS09175	COG3093	addiction module antidote protein HigA
KO461_RS09180	COG0135	phosphoribosylanthranilate isomerase activity
KO461_RS09180	COG0134	indole-3-glycerol-phosphate synthase activity
KO461_RS09190	COG0298	carbon dioxide binding
KO461_RS09205	COG3630	sodium ion export across plasma membrane
KO461_RS09235	COG0133	tryptophan synthase activity
KO461_RS09245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KO461_RS09255	COG0469	pyruvate kinase activity
KO461_RS09290	COG2390	Transcriptional regulator
KO461_RS09295	COG1070	Carbohydrate kinase
KO461_RS09300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KO461_RS09305	COG1940	carbohydrate kinase activity
KO461_RS09315	COG2969	positive regulation of protein catabolic process
KO461_RS09325	COG0314	molybdopterin synthase activity
KO461_RS09330	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KO461_RS09340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KO461_RS09420	COG3293	Transposase
KO461_RS09435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO461_RS09440	COG1120	ATPase activity
KO461_RS09450	COG3585	molybdate ion transport
KO461_RS09460	COG1120	ATPase activity
KO461_RS09465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO461_RS09470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KO461_RS09480	COG4774	siderophore transport
KO461_RS09495	COG1525	nuclease
KO461_RS09500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KO461_RS09505	COG2166	iron-sulfur cluster assembly
KO461_RS09510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KO461_RS09510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KO461_RS09515	COG1560	Kdo2-lipid A biosynthetic process
KO461_RS09520	COG3381	protein complex oligomerization
KO461_RS09525	COG2249	NAD(P)H dehydrogenase (quinone) activity
KO461_RS09535	COG0330	HflC and HflK could
KO461_RS09560	COG1858	cytochrome C peroxidase
KO461_RS09565	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KO461_RS09575	COG3065	identical protein binding
KO461_RS09580	COG1214	PFAM Peptidase M22, glycoprotease
KO461_RS09585	COG1199	ATP-dependent helicase activity
KO461_RS09590	COG0676	glucose-6-phosphate 1-epimerase activity
KO461_RS09600	COG4580	involved in the transport of maltose and maltodextrins
KO461_RS09605	COG3842	ATPase activity
KO461_RS09610	COG2182	Extracellular solute-binding protein
KO461_RS09620	COG3833	ABC-type maltose transport systems, permease component
KO461_RS09625	COG0366	Alpha amylase catalytic
KO461_RS09630	COG3842	ATPase activity
KO461_RS09640	COG1840	ABC-type Fe3 transport system, periplasmic component
KO461_RS09650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KO461_RS09660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KO461_RS09665	COG0633	Ferredoxin
KO461_RS09675	COG1280	lysine exporter protein (LysE YggA)
KO461_RS09680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KO461_RS09685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KO461_RS09695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KO461_RS09705	COG0166	Belongs to the GPI family
KO461_RS09715	COG0305	Participates in initiation and elongation during chromosome replication
KO461_RS09720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KO461_RS09725	COG4591	ABC-type transport system involved in lipoprotein release permease component
KO461_RS09730	COG1136	(ABC) transporter
KO461_RS09735	COG4591	ABC-type transport system involved in lipoprotein release permease component
KO461_RS09780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KO461_RS09785	COG1136	(ABC) transporter
KO461_RS09785	COG0577	efflux transmembrane transporter activity
KO461_RS09790	COG1538	Outer membrane efflux protein
KO461_RS09800	COG2824	Alkylphosphonate utilization operon protein PhnA
KO461_RS09810	COG0564	pseudouridine synthase activity
KO461_RS09815	COG2431	L-lysine efflux transmembrane transporter activity
KO461_RS09820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KO461_RS09825	COG0406	alpha-ribazole phosphatase activity
KO461_RS09830	COG0285	dihydrofolate synthase activity
KO461_RS09845	COG0142	geranyltranstransferase activity
KO461_RS09855	COG1349	DNA-binding transcription factor activity
KO461_RS09860	COG1063	alcohol dehydrogenase
KO461_RS09865	COG3775	system Galactitol-specific IIC component
KO461_RS09875	COG3684	Belongs to the aldolase LacD family
KO461_RS09885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KO461_RS09890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KO461_RS09910	COG2801	Transposase and inactivated derivatives
KO461_RS09915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KO461_RS09920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KO461_RS09930	COG2062	phosphohistidine phosphatase, SixA
KO461_RS09945	COG3100	YcgL domain-containing protein
KO461_RS09955	COG0791	NLP P60 protein
KO461_RS09965	COG2890	protein-(glutamine-N5) methyltransferase activity
KO461_RS09970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KO461_RS09975	COG3133	Outer membrane lipoprotein
KO461_RS09990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KO461_RS09995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KO461_RS10005	COG0307	riboflavin synthase, alpha
KO461_RS10010	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KO461_RS10015	COG3657	addiction module killer protein
KO461_RS10020	COG1534	Rna-binding protein
KO461_RS10025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KO461_RS10030	COG2027	D-alanyl-D-alanine carboxypeptidase
KO461_RS10040	COG0303	'Molybdopterin
KO461_RS10045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KO461_RS10050	COG3118	belongs to the thioredoxin family
KO461_RS10055	COG0492	ferredoxin-NADP+ reductase activity
KO461_RS10060	COG4988	ABC transporter
KO461_RS10065	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KO461_RS10075	COG1946	Acyl-CoA thioesterase
KO461_RS10080	COG0515	serine threonine protein kinase
KO461_RS10100	COG0671	phosphoesterase, PA-phosphatase related
KO461_RS10115	COG1088	dTDP-glucose 4,6-dehydratase activity
KO461_RS10120	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
KO461_RS10125	COG0708	Exodeoxyribonuclease III
KO461_RS10150	COG1216	Glycosyl transferase, family 2
KO461_RS10155	COG2246	polysaccharide biosynthetic process
KO461_RS10200	COG2951	lytic endotransglycosylase activity
KO461_RS10205	COG1216	Glycosyl transferase, family 2
KO461_RS10210	COG1216	Glycosyl transferase, family 2
KO461_RS10220	COG3306	glycosyltransferase involved in LPS biosynthesis
KO461_RS10230	COG5039	Polysaccharide pyruvyl transferase
KO461_RS10235	COG2161	toxin-antitoxin pair type II binding
KO461_RS10240	COG4115	mRNA cleavage
KO461_RS10245	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KO461_RS10250	COG1793	dna ligase
KO461_RS10255	COG0210	DNA helicase
KO461_RS10260	COG2610	gluconate transmembrane transporter activity
KO461_RS10265	COG3265	gluconokinase activity
KO461_RS10270	COG1609	Transcriptional regulator
KO461_RS10285	COG0437	4 iron, 4 sulfur cluster binding
KO461_RS10290	COG2864	formate dehydrogenase
KO461_RS10295	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KO461_RS10300	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KO461_RS10305	COG0651	ATP synthesis coupled electron transport
KO461_RS10310	COG0650	Formate hydrogenlyase subunit 4
KO461_RS10315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KO461_RS10320	COG4237	Hydrogenase 4 membrane
KO461_RS10325	COG0651	ATP synthesis coupled electron transport
KO461_RS10330	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
KO461_RS10330	COG3261	NADH dehydrogenase
KO461_RS10335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KO461_RS10340	COG3260	NADH ubiquinone oxidoreductase 20
KO461_RS10350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KO461_RS10385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KO461_RS10395	COG0508	dehydrogenase complex catalyzes the overall conversion of
KO461_RS10400	COG0567	Dehydrogenase, E1 component
KO461_RS10405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KO461_RS10410	COG3108	Peptidase M15
KO461_RS10415	COG2989	Protein conserved in bacteria
KO461_RS10420	COG0793	Belongs to the peptidase S41A family
KO461_RS10425	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
KO461_RS10430	COG2995	paraquat-inducible protein a
KO461_RS10435	COG3008	intermembrane lipid transfer
KO461_RS10445	COG3842	ATPase activity
KO461_RS10450	COG1176	ABC-type spermidine putrescine transport system, permease component I
KO461_RS10455	COG1177	transmembrane transport
KO461_RS10460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KO461_RS10475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KO461_RS10480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KO461_RS10495	COG1522	sequence-specific DNA binding
KO461_RS10505	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KO461_RS10510	COG1178	ABC-type Fe3 transport system permease component
KO461_RS10515	COG4143	(ABC) transporter
KO461_RS10520	COG0351	phosphomethylpyrimidine kinase
KO461_RS10520	COG0351	phosphomethylpyrimidine kinase
KO461_RS10590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KO461_RS10610	COG2920	part of a sulfur-relay system
KO461_RS10620	COG1121	(ABC) transporter
KO461_RS10625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KO461_RS10630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KO461_RS10650	COG3304	Inner membrane component domain
KO461_RS10655	COG1289	transmembrane transporter activity
KO461_RS10670	COG3958	Transketolase
KO461_RS10675	COG3959	Transketolase, thiamine diphosphate binding domain
KO461_RS10710	COG3501	Rhs element vgr protein
KO461_RS10715	COG4953	penicillin-binding protein 1C
KO461_RS10720	COG2855	membrane
KO461_RS10735	COG0157	Belongs to the NadC ModD family
KO461_RS10745	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KO461_RS10750	COG0725	ABC transporter, periplasmic molybdate-binding protein
KO461_RS10760	COG5339	Protein conserved in bacteria
KO461_RS10765	COG0443	Heat shock 70 kDa protein
KO461_RS10770	COG0484	heat shock protein binding
KO461_RS10775	COG2337	Toxic component of a toxin-antitoxin (TA) module
KO461_RS10790	COG0626	cystathionine gamma-synthase activity
KO461_RS10795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KO461_RS10815	COG2801	Transposase and inactivated derivatives
KO461_RS10825	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KO461_RS10830	COG2999	glutathione oxidoreductase activity
KO461_RS10835	COG1530	ribonuclease E activity
KO461_RS10840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KO461_RS10890	COG1840	ABC-type Fe3 transport system, periplasmic component
KO461_RS10895	COG1840	ABC-type Fe3 transport system, periplasmic component
KO461_RS10925	COG2860	membrane
KO461_RS10940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KO461_RS10950	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KO461_RS10955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KO461_RS10960	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KO461_RS10965	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KO461_RS10980	COG2914	Belongs to the UPF0125 (RnfH) family
KO461_RS10985	COG2850	peptidyl-arginine hydroxylation
KO461_RS10990	COG1570	exodeoxyribonuclease VII activity
KO461_RS11000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_RS11005	COG1137	ATPase activity
KO461_RS11010	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KO461_RS11015	COG3117	lipopolysaccharide transmembrane transporter activity
KO461_RS11020	COG1127	ABC transporter
KO461_RS11025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KO461_RS11030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KO461_RS11035	COG2854	intermembrane phospholipid transfer
KO461_RS11040	COG3113	response to antibiotic
KO461_RS11045	COG5007	Belongs to the BolA IbaG family
KO461_RS11055	COG3691	Protein conserved in bacteria
KO461_RS11065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KO461_RS11075	COG0861	Integral membrane protein TerC family
KO461_RS11085	COG1217	gtp-binding protein TYPA
KO461_RS11090	COG3266	domain, Protein
KO461_RS11090	COG3468	outer membrane autotransporter barrel domain protein
KO461_RS11095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KO461_RS11100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KO461_RS11115	COG0517	IMP dehydrogenase activity
KO461_RS11115	COG1125	glycine betaine transport
KO461_RS11120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KO461_RS11130	COG0527	aspartate kinase activity
KO461_RS11130	COG0460	homoserine dehydrogenase
KO461_RS11145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KO461_RS11150	COG2091	lysine biosynthetic process via aminoadipic acid
KO461_RS11155	COG0330	HflC and HflK could
KO461_RS11160	COG0330	HflC and HflK could
KO461_RS11170	COG4974	Belongs to the 'phage' integrase family
KO461_RS11190	COG3061	Opacity-associated protein A
KO461_RS11190	COG3266	domain, Protein
KO461_RS11195	COG1509	lysine 2,3-aminomutase activity
KO461_RS11205	COG3033	Beta-eliminating lyase
KO461_RS11210	COG0814	amino acid
KO461_RS11215	COG2964	Protein conserved in bacteria
KO461_RS11220	COG5413	integral membrane protein
KO461_RS11230	COG0204	Acyl-transferase
KO461_RS11240	COG0697	spore germination
KO461_RS11245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KO461_RS11250	COG1882	Formate acetyltransferase
KO461_RS11255	COG2116	formate transmembrane transporter activity
KO461_RS11260	COG0537	adenosine 5'-monophosphoramidase activity
KO461_RS11280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KO461_RS11305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KO461_RS11320	COG0681	Belongs to the peptidase S26 family
KO461_RS11405	COG3775	system Galactitol-specific IIC component