locus-tag	class	description
D11S_RS00015	COG2842	Transposition protein
D11S_RS00020	COG2801	Transposase and inactivated derivatives
D11S_RS00025	COG3423	Transcriptional regulator
D11S_RS00030	COG2932	Transcriptional regulator
D11S_RS00045	COG0688	phosphatidylethanolamine metabolic process
D11S_RS00050	COG0545	Peptidyl-prolyl cis-trans isomerase
D11S_RS00060	COG2966	Psort location CytoplasmicMembrane, score
D11S_RS00065	COG3610	response to peptide
D11S_RS00070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D11S_RS00075	COG1253	flavin adenine dinucleotide binding
D11S_RS00085	COG0084	hydrolase, TatD family'
D11S_RS00090	COG0470	DNA polymerase III
D11S_RS00095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D11S_RS00100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D11S_RS00105	COG0347	Belongs to the P(II) protein family
D11S_RS00110	COG1349	DNA-binding transcription factor activity
D11S_RS00115	COG2084	Dehydrogenase
D11S_RS00120	COG3395	kinase activity
D11S_RS00125	COG0235	Class ii aldolase
D11S_RS00130	COG3622	Belongs to the hyi family
D11S_RS00135	COG2610	gluconate transmembrane transporter activity
D11S_RS00145	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D11S_RS00155	COG0561	phosphatase activity
D11S_RS00180	COG3085	chromosome segregation
D11S_RS00185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D11S_RS00190	COG3084	Protein conserved in bacteria
D11S_RS00195	COG0746	molybdenum cofactor guanylyltransferase activity
D11S_RS00205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_RS00205	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_RS00210	COG1105	Belongs to the carbohydrate kinase PfkB family
D11S_RS00215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D11S_RS00215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D11S_RS00215	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D11S_RS00250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D11S_RS00270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D11S_RS00295	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D11S_RS00300	COG0255	Belongs to the universal ribosomal protein uL29 family
D11S_RS00305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D11S_RS00310	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D11S_RS00315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D11S_RS00320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D11S_RS00325	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D11S_RS00330	COG0089	rRNA binding
D11S_RS00335	COG0088	Forms part of the polypeptide exit tunnel
D11S_RS00340	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D11S_RS00345	COG0051	transcription antitermination factor activity, RNA binding
D11S_RS00350	COG0583	DNA-binding transcription factor activity
D11S_RS00355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D11S_RS00360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D11S_RS00365	COG2031	fatty acid transporter
D11S_RS00370	COG0183	Belongs to the thiolase family
D11S_RS00380	COG1288	antiporter activity
D11S_RS00385	COG0549	Belongs to the carbamate kinase family
D11S_RS00390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D11S_RS00395	COG0038	chloride channel
D11S_RS00400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D11S_RS00410	COG1522	sequence-specific DNA binding
D11S_RS00415	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D11S_RS00425	COG1393	Belongs to the ArsC family
D11S_RS00435	COG3036	rescue of stalled ribosome
D11S_RS00440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D11S_RS00445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D11S_RS00450	COG2841	Protein conserved in bacteria
D11S_RS00465	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D11S_RS00475	COG0569	domain protein
D11S_RS00480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D11S_RS00480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D11S_RS00525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D11S_RS00545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D11S_RS00550	COG2990	Protein conserved in bacteria
D11S_RS00580	COG0210	DNA helicase
D11S_RS00615	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D11S_RS00655	COG2861	carbohydrate metabolic process
D11S_RS00660	COG4942	peptidase
D11S_RS00665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D11S_RS00680	COG2853	Lipoprotein
D11S_RS00685	COG0747	negative chemotaxis
D11S_RS00720	COG0814	amino acid
D11S_RS00730	COG4783	chaperone-mediated protein folding
D11S_RS00735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D11S_RS00745	COG0552	protein localization to endoplasmic reticulum
D11S_RS00750	COG0742	ribosomal rna small subunit methyltransferase
D11S_RS00755	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_RS00755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D11S_RS00760	COG3715	PTS system
D11S_RS00765	COG3716	PTS system mannose fructose sorbose family IID component
D11S_RS00770	COG0561	phosphatase activity
D11S_RS00775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D11S_RS00790	COG0726	polysaccharide deacetylase
D11S_RS00790	COG1649	PFAM Uncharacterised BCR, COG1649
D11S_RS00795	COG1215	transferase activity, transferring glycosyl groups
D11S_RS00805	COG2271	Major facilitator Superfamily
D11S_RS00840	COG0513	Belongs to the DEAD box helicase family
D11S_RS00850	COG3201	nicotinamide mononucleotide transporter
D11S_RS00865	COG1238	metal cluster binding
D11S_RS00870	COG0110	maltose O-acetyltransferase activity
D11S_RS00900	COG0210	DNA helicase
D11S_RS00905	COG5645	(Lipo)protein
D11S_RS00915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D11S_RS00915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D11S_RS00930	COG0737	Belongs to the 5'-nucleotidase family
D11S_RS00940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D11S_RS00950	COG0859	PFAM glycosyl transferase family 9
D11S_RS00955	COG0754	glutathionylspermidine amidase activity
D11S_RS00960	COG3005	denitrification pathway
D11S_RS00965	COG3043	anaerobic respiration
D11S_RS00970	COG0348	domain, Protein
D11S_RS00975	COG0437	4 iron, 4 sulfur cluster binding
D11S_RS00980	COG0243	molybdopterin cofactor binding
D11S_RS00985	COG3062	negative regulation of establishment of protein localization
D11S_RS00990	COG3850	Histidine kinase
D11S_RS00995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D11S_RS01005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D11S_RS01010	COG3070	regulator of competence-specific genes
D11S_RS01030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D11S_RS01040	COG0583	DNA-binding transcription factor activity
D11S_RS01045	COG2962	Rard protein
D11S_RS01060	COG0551	DNA topoisomerase type I activity
D11S_RS01085	COG0705	Rhomboid family
D11S_RS01090	COG1349	DNA-binding transcription factor activity
D11S_RS01105	COG4178	(ABC) transporter
D11S_RS01120	COG0233	cytoplasmic translational termination
D11S_RS01135	COG0575	Belongs to the CDS family
D11S_RS01150	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D11S_RS01170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D11S_RS01185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D11S_RS01195	COG4589	Belongs to the CDS family
D11S_RS01200	COG0521	Mo-molybdopterin cofactor biosynthetic process
D11S_RS01240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D11S_RS01250	COG0251	oxidation-reduction process
D11S_RS01255	COG2137	regulation of response to DNA damage stimulus
D11S_RS01260	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D11S_RS01265	COG0488	(ABC) transporter
D11S_RS01270	COG2095	MarC family integral membrane protein
D11S_RS01295	COG2963	transposase activity
D11S_RS01310	COG1349	DNA-binding transcription factor activity
D11S_RS01320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D11S_RS01330	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D11S_RS01355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D11S_RS01360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D11S_RS01365	COG0765	amino acid transport
D11S_RS01370	COG1126	abc transporter atp-binding protein
D11S_RS01375	COG2168	tRNA wobble position uridine thiolation
D11S_RS01385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D11S_RS01390	COG2964	Protein conserved in bacteria
D11S_RS01395	COG0545	Peptidyl-prolyl cis-trans isomerase
D11S_RS01400	COG2900	Belongs to the SlyX family
D11S_RS01405	COG0678	peroxiredoxin activity
D11S_RS01405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D11S_RS01410	COG0583	DNA-binding transcription factor activity
D11S_RS01415	COG1309	transcriptional regulator
D11S_RS01420	COG1132	(ABC) transporter
D11S_RS01425	COG4988	ABC transporter
D11S_RS01430	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D11S_RS01435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D11S_RS01440	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D11S_RS01450	COG1045	serine acetyltransferase
D11S_RS01460	COG1494	fructose-1,6-bisphosphatase
D11S_RS01470	COG0716	FMN binding
D11S_RS01480	COG0702	epimerase
D11S_RS01485	COG1733	regulation of RNA biosynthetic process
D11S_RS01495	COG3312	ion transport
D11S_RS01515	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D11S_RS01525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D11S_RS01540	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D11S_RS01570	COG3716	PTS system mannose fructose sorbose family IID component
D11S_RS01575	COG3715	PTS system
D11S_RS01580	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_RS01580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D11S_RS01585	COG2814	Major facilitator Superfamily
D11S_RS01590	COG1609	Transcriptional regulator
D11S_RS01590	COG2207	Transcriptional regulator
D11S_RS01600	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D11S_RS01610	COG1129	ABC transporter
D11S_RS01615	COG4213	ABC transporter substrate-binding protein
D11S_RS01620	COG2115	Belongs to the xylose isomerase family
D11S_RS01625	COG1070	Carbohydrate kinase
D11S_RS01640	COG2801	Transposase and inactivated derivatives
D11S_RS01645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D11S_RS01650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D11S_RS01655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D11S_RS01660	COG3719	Belongs to the RNase T2 family
D11S_RS01670	COG0191	fructose-bisphosphate aldolase activity
D11S_RS01675	COG3307	-O-antigen
D11S_RS01680	COG2267	carboxylic ester hydrolase activity
D11S_RS01685	COG0561	phosphatase activity
D11S_RS01705	COG2177	Part of the ABC transporter FtsEX involved in
D11S_RS01710	COG2884	Cell division ATP-binding protein ftsE
D11S_RS01720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D11S_RS01750	COG1238	metal cluster binding
D11S_RS01760	COG1388	LysM domain
D11S_RS01760	COG4942	peptidase
D11S_RS01775	COG0463	Glycosyl transferase, family 2
D11S_RS01780	COG1519	Transferase
D11S_RS01795	COG0859	PFAM glycosyl transferase family 9
D11S_RS01800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D11S_RS01805	COG1917	Cupin 2, conserved barrel domain protein
D11S_RS01805	COG4977	sequence-specific DNA binding
D11S_RS01810	COG1132	(ABC) transporter
D11S_RS01845	COG0758	DNA mediated transformation
D11S_RS01850	COG0584	glycerophosphoryl diester phosphodiesterase
D11S_RS01855	COG2271	Major facilitator Superfamily
D11S_RS01865	COG0557	exoribonuclease II activity
D11S_RS01870	COG1077	Cell shape determining protein MreB Mrl
D11S_RS01875	COG1792	Involved in formation and maintenance of cell shape
D11S_RS01880	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D11S_RS01910	COG0006	proline dipeptidase activity
D11S_RS01930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D11S_RS01945	COG1496	oxidoreductase activity
D11S_RS01950	COG1368	sulfuric ester hydrolase activity
D11S_RS01955	COG0778	Nitroreductase
D11S_RS01965	COG0762	integral membrane protein
D11S_RS01975	COG0500	methyltransferase
D11S_RS01980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D11S_RS01985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D11S_RS01990	COG1309	transcriptional regulator
D11S_RS01995	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D11S_RS02005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D11S_RS02020	COG3306	glycosyltransferase involved in LPS biosynthesis
D11S_RS02030	COG3306	glycosyltransferase involved in LPS biosynthesis
D11S_RS02065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D11S_RS02075	COG1309	transcriptional regulator
D11S_RS02090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D11S_RS02095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D11S_RS02100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D11S_RS02105	COG4972	Pilus assembly protein
D11S_RS02125	COG4796	Type ii and iii secretion system protein
D11S_RS02140	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D11S_RS02150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D11S_RS02155	COG0789	Transcriptional regulator
D11S_RS02160	COG4701	Protein of unknown function (DUF721)
D11S_RS02175	COG0494	nUDIX hydrolase
D11S_RS02180	COG1466	dna polymerase III delta subunit
D11S_RS02185	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D11S_RS02200	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
D11S_RS02205	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
D11S_RS02210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D11S_RS02215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D11S_RS02220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D11S_RS02240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D11S_RS02250	COG4221	oxidoreductase activity
D11S_RS02255	COG0789	Transcriptional regulator
D11S_RS02260	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D11S_RS02265	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D11S_RS02275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D11S_RS02280	COG4137	Cytochrome C assembly protein
D11S_RS02285	COG4536	flavin adenine dinucleotide binding
D11S_RS02290	COG0811	peptide transport
D11S_RS02295	COG0848	biopolymer transport protein
D11S_RS02315	COG0243	molybdopterin cofactor binding
D11S_RS02320	COG0437	4 iron, 4 sulfur cluster binding
D11S_RS02325	COG3302	dmso reductase anchor subunit
D11S_RS02330	COG3381	protein complex oligomerization
D11S_RS02335	COG2221	Nitrite and sulphite reductase 4Fe-4S
D11S_RS02335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D11S_RS02345	COG4545	Glutaredoxin-related protein
D11S_RS02370	COG0805	protein transport
D11S_RS02375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D11S_RS02380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D11S_RS02385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D11S_RS02390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D11S_RS02395	COG1011	Hydrolase
D11S_RS02400	COG0494	nUDIX hydrolase
D11S_RS02405	COG4977	sequence-specific DNA binding
D11S_RS02405	COG1917	Cupin 2, conserved barrel domain protein
D11S_RS02410	COG3059	membrane
D11S_RS02415	COG1297	OPT oligopeptide transporter protein
D11S_RS02425	COG1218	3'(2'),5'-bisphosphate nucleotidase
D11S_RS02430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D11S_RS02435	COG0363	glucosamine-6-phosphate deaminase activity
D11S_RS02445	COG1794	racemase activity, acting on amino acids and derivatives
D11S_RS02450	COG4545	Glutaredoxin-related protein
D11S_RS02465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D11S_RS02470	COG1028	Short-chain dehydrogenase reductase Sdr
D11S_RS02480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D11S_RS02535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D11S_RS02560	COG1011	Hydrolase
D11S_RS02570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D11S_RS02575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D11S_RS02595	COG1596	polysaccharide export
D11S_RS02595	COG1555	photosystem II stabilization
D11S_RS02600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D11S_RS02605	COG0561	phosphatase activity
D11S_RS02610	COG1040	competence protein
D11S_RS02625	COG1114	Component of the transport system for branched-chain amino acids
D11S_RS02650	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D11S_RS02660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D11S_RS02670	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D11S_RS02690	COG0201	protein transport
D11S_RS02710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D11S_RS02730	COG0814	amino acid
D11S_RS02735	COG2129	metallophosphoesterase
D11S_RS02740	COG3172	ATPase kinase involved in NAD metabolism
D11S_RS02765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D11S_RS02770	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D11S_RS02815	COG2801	Transposase and inactivated derivatives
D11S_RS02825	COG0859	PFAM glycosyl transferase family 9
D11S_RS02830	COG1027	Aspartate ammonia-lyase
D11S_RS02840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D11S_RS02845	COG0459	protein refolding
D11S_RS02865	COG2801	Transposase and inactivated derivatives
D11S_RS02875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D11S_RS02885	COG1381	Involved in DNA repair and RecF pathway recombination
D11S_RS02890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D11S_RS02910	COG0354	folic acid binding
D11S_RS02915	COG1561	YicC-like family, N-terminal region
D11S_RS02925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D11S_RS02940	COG3842	ATPase activity
D11S_RS02945	COG1178	ABC-type Fe3 transport system permease component
D11S_RS02950	COG1840	ABC-type Fe3 transport system, periplasmic component
D11S_RS02955	COG3171	Protein conserved in bacteria
D11S_RS02965	COG1194	a g-specific adenine glycosylase
D11S_RS02990	COG3056	Lipoprotein
D11S_RS02995	COG0271	Belongs to the BolA IbaG family
D11S_RS03010	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D11S_RS03015	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D11S_RS03020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D11S_RS03025	COG2871	sodium ion transport
D11S_RS03030	COG1477	protein flavinylation
D11S_RS03035	COG2991	Protein conserved in bacteria
D11S_RS03050	COG0148	phosphopyruvate hydratase activity
D11S_RS03065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D11S_RS03070	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D11S_RS03075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D11S_RS03080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D11S_RS03085	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D11S_RS03100	COG3956	TIGRFAM MazG family protein
D11S_RS03105	COG0402	S-adenosylhomocysteine deaminase activity
D11S_RS03110	COG3083	sulfuric ester hydrolase activity
D11S_RS03115	COG3082	Protein of unknown function (DUF1414)
D11S_RS03125	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D11S_RS03130	COG0745	RESPONSE REGULATOR receiver
D11S_RS03135	COG2205	protein histidine kinase activity
D11S_RS03140	COG0786	glutamate:sodium symporter activity
D11S_RS03145	COG1490	D-aminoacyl-tRNA deacylase activity
D11S_RS03160	COG2258	MOSC domain
D11S_RS03165	COG0433	COG0433 Predicted ATPase
D11S_RS03180	COG0656	L-ascorbic acid biosynthetic process
D11S_RS03185	COG0667	Aldo Keto reductase
D11S_RS03190	COG2272	Belongs to the type-B carboxylesterase lipase family
D11S_RS03215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D11S_RS03220	COG1349	DNA-binding transcription factor activity
D11S_RS03230	COG3068	Protein conserved in bacteria
D11S_RS03235	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D11S_RS03255	COG0248	Ppx GppA phosphatase
D11S_RS03260	COG2911	Protein conserved in bacteria
D11S_RS03265	COG0729	surface antigen
D11S_RS03270	COG2197	response regulator
D11S_RS03280	COG0181	hydroxymethylbilane synthase activity
D11S_RS03290	COG2959	enzyme of heme biosynthesis
D11S_RS03295	COG3071	HemY protein
D11S_RS03300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D11S_RS03310	COG1595	DNA-templated transcription, initiation
D11S_RS03320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D11S_RS03340	COG0583	DNA-binding transcription factor activity
D11S_RS03345	COG2183	response to ionizing radiation
D11S_RS03355	COG1172	Belongs to the binding-protein-dependent transport system permease family
D11S_RS03360	COG1129	ABC transporter
D11S_RS03365	COG1879	ABC-type sugar transport system periplasmic component
D11S_RS03395	COG1072	(Pantothenic acid kinase))
D11S_RS03400	COG0187	DNA topoisomerase II activity
D11S_RS03405	COG0514	ATP-dependent DNA helicase (RecQ)
D11S_RS03420	COG0019	diaminopimelate decarboxylase activity
D11S_RS03425	COG3477	response to acidic pH
D11S_RS03430	COG2818	Glycosylase
D11S_RS03435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D11S_RS03445	COG2195	Cleaves the N-terminal amino acid of tripeptides
D11S_RS03450	COG0300	oxidoreductase activity
D11S_RS03455	COG1763	Mo-molybdopterin cofactor biosynthetic process
D11S_RS03460	COG3086	response to oxidative stress
D11S_RS03465	COG3026	antisigma factor binding
D11S_RS03470	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D11S_RS03475	COG1595	DNA-templated transcription, initiation
D11S_RS03490	COG0442	prolyl-tRNA aminoacylation
D11S_RS03495	COG1921	L-seryl-tRNASec selenium transferase activity
D11S_RS03500	COG3276	selenocysteine insertion sequence binding
D11S_RS03510	COG1285	pathogenesis
D11S_RS03520	COG0733	neurotransmitter:sodium symporter activity
D11S_RS03590	COG4964	Belongs to the GSP D family
D11S_RS03615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D11S_RS03625	COG1444	tRNA N-acetyltransferase activity
D11S_RS03630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D11S_RS03640	COG1126	abc transporter atp-binding protein
D11S_RS03645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D11S_RS03650	COG4215	(ABC) transporter
D11S_RS03655	COG4160	amino acid transport
D11S_RS03660	COG1966	Carbon starvation protein
D11S_RS03675	COG3116	cell division
D11S_RS03680	COG0768	penicillin binding
D11S_RS03690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D11S_RS03700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D11S_RS03710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D11S_RS03725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D11S_RS03730	COG0849	cell division
D11S_RS03735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D11S_RS03750	COG0326	Molecular chaperone. Has ATPase activity
D11S_RS03755	COG1393	Belongs to the ArsC family
D11S_RS03765	COG1876	peptidase activity
D11S_RS03770	COG0494	nUDIX hydrolase
D11S_RS03775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D11S_RS03820	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D11S_RS03830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D11S_RS03835	COG1053	succinate dehydrogenase
D11S_RS03850	COG1120	ATPase activity
D11S_RS03855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D11S_RS03860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D11S_RS03865	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D11S_RS03870	COG1408	metallophosphoesterase
D11S_RS03880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D11S_RS03885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D11S_RS03900	COG0582	viral genome integration into host DNA
D11S_RS03920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D11S_RS03930	COG0741	lytic transglycosylase activity
D11S_RS03935	COG2350	Protein conserved in bacteria
D11S_RS03940	COG1607	acyl-coa hydrolase
D11S_RS03960	COG0497	DNA recombination
D11S_RS03970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D11S_RS03980	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D11S_RS03980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D11S_RS03985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D11S_RS03990	COG5002	protein histidine kinase activity
D11S_RS03990	COG2198	Histidine kinase
D11S_RS03990	COG0784	Response regulator, receiver
D11S_RS03995	COG4211	Belongs to the binding-protein-dependent transport system permease family
D11S_RS04000	COG1129	ABC transporter
D11S_RS04005	COG1879	ABC-type sugar transport system periplasmic component
D11S_RS04010	COG1609	Transcriptional regulator
D11S_RS04015	COG1085	galactose-1-phosphate uridylyltransferase
D11S_RS04020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D11S_RS04025	COG2017	converts alpha-aldose to the beta-anomer
D11S_RS04040	COG0471	metal ion transport
D11S_RS04045	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
D11S_RS04045	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D11S_RS04050	COG3051	citrate lyase alpha subunit
D11S_RS04055	COG2301	Belongs to the HpcH HpaI aldolase family
D11S_RS04065	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D11S_RS04070	COG4535	Mg2 and Co2 transporter CorC
D11S_RS04090	COG0105	UTP biosynthetic process
D11S_RS04100	COG0489	protein tyrosine kinase activity
D11S_RS04105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D11S_RS04105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D11S_RS04110	COG2975	iron-sulfur cluster assembly
D11S_RS04115	COG0633	Ferredoxin
D11S_RS04120	COG0443	Heat shock 70 kDa protein
D11S_RS04135	COG0822	iron-sulfur transferase activity
D11S_RS04145	COG1959	2 iron, 2 sulfur cluster binding
D11S_RS04150	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D11S_RS04175	COG1840	ABC-type Fe3 transport system, periplasmic component
D11S_RS04180	COG1840	ABC-type Fe3 transport system, periplasmic component
D11S_RS04230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D11S_RS04235	COG1530	ribonuclease E activity
D11S_RS04245	COG2999	glutathione oxidoreductase activity
D11S_RS04250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D11S_RS04300	COG3021	interspecies interaction between organisms
D11S_RS04340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D11S_RS04345	COG0626	cystathionine gamma-synthase activity
D11S_RS04360	COG2337	Toxic component of a toxin-antitoxin (TA) module
D11S_RS04365	COG0484	heat shock protein binding
D11S_RS04370	COG0443	Heat shock 70 kDa protein
D11S_RS04375	COG5339	Protein conserved in bacteria
D11S_RS04385	COG3102	Protein conserved in bacteria
D11S_RS04390	COG3133	Outer membrane lipoprotein
D11S_RS04395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D11S_RS04400	COG2890	protein-(glutamine-N5) methyltransferase activity
D11S_RS04410	COG0791	NLP P60 protein
D11S_RS04420	COG3100	YcgL domain-containing protein
D11S_RS04435	COG2062	phosphohistidine phosphatase, SixA
D11S_RS04445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D11S_RS04450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D11S_RS04465	COG2932	Transcriptional regulator
D11S_RS04475	COG0516	GMP reductase activity
D11S_RS04475	COG0517	IMP dehydrogenase activity
D11S_RS04480	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D11S_RS04480	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D11S_RS04510	COG4172	Belongs to the ABC transporter superfamily
D11S_RS04515	COG4172	Belongs to the ABC transporter superfamily
D11S_RS04520	COG4171	peptide transport system, permease
D11S_RS04525	COG4168	peptide transport system, permease
D11S_RS04530	COG4166	transmembrane transport
D11S_RS04535	COG3106	COG3106 Predicted ATPase
D11S_RS04545	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D11S_RS04550	COG1923	regulation of RNA biosynthetic process
D11S_RS04560	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D11S_RS04565	COG0860	N-Acetylmuramoyl-L-alanine amidase
D11S_RS04565	COG1388	LysM domain
D11S_RS04570	COG0802	atpase or kinase
D11S_RS04580	COG2246	polysaccharide biosynthetic process
D11S_RS04590	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D11S_RS04600	COG2194	sulfuric ester hydrolase activity
D11S_RS04625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_RS04630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D11S_RS04635	COG2190	(PTS) system
D11S_RS04640	COG0339	signal peptide processing
D11S_RS04645	COG2832	Protein of unknown function (DUF454)
D11S_RS04650	COG4166	transmembrane transport
D11S_RS04655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D11S_RS04665	COG0512	Glutamine amidotransferase of anthranilate synthase
D11S_RS04670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D11S_RS04680	COG4591	ABC-type transport system involved in lipoprotein release permease component
D11S_RS04690	COG4591	ABC-type transport system involved in lipoprotein release permease component
D11S_RS04695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D11S_RS04700	COG0305	Participates in initiation and elongation during chromosome replication
D11S_RS04710	COG0166	Belongs to the GPI family
D11S_RS04715	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D11S_RS04725	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D11S_RS04730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D11S_RS04735	COG1280	lysine exporter protein (LysE YggA)
D11S_RS04745	COG0633	Ferredoxin
D11S_RS04755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D11S_RS04765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D11S_RS04775	COG1840	ABC-type Fe3 transport system, periplasmic component
D11S_RS04785	COG3842	ATPase activity
D11S_RS04790	COG0366	Alpha amylase catalytic
D11S_RS04795	COG3833	ABC-type maltose transport systems, permease component
D11S_RS04805	COG2182	Extracellular solute-binding protein
D11S_RS04810	COG3842	ATPase activity
D11S_RS04815	COG4580	involved in the transport of maltose and maltodextrins
D11S_RS04825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D11S_RS04830	COG0303	'Molybdopterin
D11S_RS04840	COG2027	D-alanyl-D-alanine carboxypeptidase
D11S_RS04845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D11S_RS04850	COG1534	Rna-binding protein
D11S_RS04855	COG3657	addiction module killer protein
D11S_RS04860	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D11S_RS04865	COG0307	riboflavin synthase, alpha
D11S_RS04875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D11S_RS04880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D11S_RS04885	COG3955	Domain of unknown function (DUF1919)
D11S_RS04950	COG2855	membrane
D11S_RS04955	COG4953	penicillin-binding protein 1C
D11S_RS04960	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D11S_RS04985	COG3623	hexulose-6-phosphate isomerase
D11S_RS04990	COG0235	Class ii aldolase
D11S_RS04995	COG0814	amino acid
D11S_RS05010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D11S_RS05015	COG0778	Nitroreductase
D11S_RS05030	COG2268	Band 7 protein
D11S_RS05035	COG0114	fumarate hydratase activity
D11S_RS05040	COG2927	DNA polymerase III (CHI subunit)
D11S_RS05085	COG2814	Major facilitator Superfamily
D11S_RS05095	COG0783	Belongs to the Dps family
D11S_RS05105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D11S_RS05110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D11S_RS05115	COG0602	queuosine metabolic process
D11S_RS05120	COG0720	synthase
D11S_RS05125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D11S_RS05140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D11S_RS05145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D11S_RS05150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D11S_RS05155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D11S_RS05160	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
D11S_RS05165	COG0310	cobalt ion transport
D11S_RS05170	COG0310	cobalt ion transport
D11S_RS05175	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D11S_RS05180	COG1122	ATPase activity
D11S_RS05185	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D11S_RS05190	COG0409	Hydrogenase expression formation protein
D11S_RS05195	COG0309	Hydrogenase expression formation protein (HypE)
D11S_RS05210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D11S_RS05215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D11S_RS05220	COG0795	lipopolysaccharide-transporting ATPase activity
D11S_RS05225	COG0795	lipopolysaccharide-transporting ATPase activity
D11S_RS05230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D11S_RS05235	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D11S_RS05240	COG4149	molybdate abc transporter
D11S_RS05245	COG0725	ABC transporter, periplasmic molybdate-binding protein
D11S_RS05250	COG2005	Transcriptional regulator
D11S_RS05255	COG0471	metal ion transport
D11S_RS05265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D11S_RS05270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D11S_RS05270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D11S_RS05275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D11S_RS05285	COG0583	DNA-binding transcription factor activity
D11S_RS05290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D11S_RS05305	COG0039	L-malate dehydrogenase activity
D11S_RS05310	COG1438	arginine binding
D11S_RS05315	COG1090	epimerase
D11S_RS05320	COG4657	Part of a membrane complex involved in electron transport
D11S_RS05350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D11S_RS05355	COG0733	neurotransmitter:sodium symporter activity
D11S_RS05360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D11S_RS05370	COG0739	heme binding
D11S_RS05375	COG4604	ABC transporter, ATP-binding protein
D11S_RS05380	COG4605	iron ion homeostasis
D11S_RS05385	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D11S_RS05390	COG4607	ABC-type enterochelin transport system periplasmic component
D11S_RS05395	COG0737	Belongs to the 5'-nucleotidase family
D11S_RS05410	COG3111	PFAM Bacterial OB fold (BOF) protein
D11S_RS05415	COG0745	RESPONSE REGULATOR receiver
D11S_RS05420	COG0642	Histidine kinase
D11S_RS05425	COG0405	Gamma-glutamyltransferase
D11S_RS05440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D11S_RS05445	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D11S_RS05450	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
D11S_RS05485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D11S_RS05490	COG1518	maintenance of DNA repeat elements
D11S_RS05500	COG0351	phosphomethylpyrimidine kinase
D11S_RS05505	COG4143	(ABC) transporter
D11S_RS05510	COG1178	ABC-type Fe3 transport system permease component
D11S_RS05515	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D11S_RS05525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D11S_RS05530	COG3105	Protein conserved in bacteria
D11S_RS05535	COG1944	ATP diphosphatase activity
D11S_RS05545	COG3422	double-strand break repair
D11S_RS05560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D11S_RS05570	COG1846	Transcriptional regulator
D11S_RS05570	COG1940	carbohydrate kinase activity
D11S_RS05595	COG0563	adenylate kinase activity
D11S_RS05600	COG2814	Major facilitator Superfamily
D11S_RS05605	COG0375	protein maturation
D11S_RS05610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D11S_RS05615	COG3152	Membrane
D11S_RS05635	COG0825	malonyl-CoA metabolic process
D11S_RS05640	COG2351	hydroxyisourate hydrolase activity
D11S_RS05670	COG1598	PFAM Uncharacterised protein family UPF0150
D11S_RS05685	COG3617	BRO family, N-terminal domain
D11S_RS05705	COG3041	Addiction module toxin RelE StbE family
D11S_RS05710	COG3077	Addiction module antitoxin, RelB DinJ family
D11S_RS05720	COG3069	C4-dicarboxylate transmembrane transporter activity
D11S_RS05735	COG0195	Participates in both transcription termination and antitermination
D11S_RS05750	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D11S_RS05765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D11S_RS05775	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D11S_RS05780	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D11S_RS05790	COG3177	Filamentation induced by cAMP protein fic
D11S_RS05800	COG3842	ATPase activity
D11S_RS05805	COG1175	transmembrane transport
D11S_RS05810	COG0395	ABC-type sugar transport system, permease component
D11S_RS05820	COG0322	excinuclease ABC activity
D11S_RS05830	COG2835	tetraacyldisaccharide 4'-kinase activity
D11S_RS05835	COG1663	tetraacyldisaccharide 4'-kinase activity
D11S_RS05840	COG1132	(ABC) transporter
D11S_RS05845	COG0658	competence protein
D11S_RS05845	COG2333	competence protein COMEC
D11S_RS05850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D11S_RS05865	COG0280	phosphate acetyltransferase
D11S_RS05865	COG0857	belongs to the CobB CobQ family
D11S_RS05870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D11S_RS05875	COG3092	negative regulation of chromosome organization
D11S_RS05880	COG1286	toxin biosynthetic process
D11S_RS05885	COG1640	4-alpha-glucanotransferase
D11S_RS05890	COG0058	SHG alpha-glucan phosphorylase activity
D11S_RS05895	COG2909	trisaccharide binding
D11S_RS05905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D11S_RS05910	COG0508	dehydrogenase complex catalyzes the overall conversion of
D11S_RS05915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D11S_RS05920	COG0778	Nitroreductase
D11S_RS05925	COG0616	signal peptide processing
D11S_RS05930	COG1605	Chorismate mutase
D11S_RS05930	COG0287	Prephenate dehydrogenase
D11S_RS05935	COG0009	L-threonylcarbamoyladenylate synthase
D11S_RS05945	COG0583	DNA-binding transcription factor activity
D11S_RS05955	COG3099	Belongs to the UPF0263 family
D11S_RS05965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D11S_RS05970	COG2949	membrane
D11S_RS05990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D11S_RS05995	COG0785	Cytochrome C biogenesis protein
D11S_RS06000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D11S_RS06000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D11S_RS06005	COG0288	reversible hydration of carbon dioxide
D11S_RS06010	COG2823	Periplasmic or secreted lipoprotein
D11S_RS06015	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D11S_RS06020	COG0792	nuclease activity
D11S_RS06030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D11S_RS06040	COG1252	NADH dehydrogenase
D11S_RS06050	COG0616	signal peptide processing
D11S_RS06055	COG2885	chlorophyll binding
D11S_RS06055	COG3047	cAMP biosynthetic process
D11S_RS06100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D11S_RS06105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D11S_RS06140	COG1349	DNA-binding transcription factor activity
D11S_RS06150	COG0142	geranyltranstransferase activity
D11S_RS06165	COG0285	dihydrofolate synthase activity
D11S_RS06170	COG0406	alpha-ribazole phosphatase activity
D11S_RS06175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D11S_RS06180	COG2431	L-lysine efflux transmembrane transporter activity
D11S_RS06195	COG2824	Alkylphosphonate utilization operon protein PhnA
D11S_RS06225	COG1538	Outer membrane efflux protein
D11S_RS06230	COG1136	(ABC) transporter
D11S_RS06230	COG0577	efflux transmembrane transporter activity
D11S_RS06235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D11S_RS06260	COG1523	belongs to the glycosyl hydrolase 13 family
D11S_RS06275	COG0058	SHG alpha-glucan phosphorylase activity
D11S_RS06280	COG0586	Pfam SNARE associated Golgi protein
D11S_RS06285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D11S_RS06295	COG1686	Belongs to the peptidase S11 family
D11S_RS06300	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D11S_RS06310	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D11S_RS06315	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D11S_RS06320	COG0697	spore germination
D11S_RS06325	COG2925	Exonuclease
D11S_RS06340	COG2801	Transposase and inactivated derivatives
D11S_RS06355	COG1528	Iron-storage protein
D11S_RS06360	COG1528	Iron-storage protein
D11S_RS06365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D11S_RS06370	COG0589	response to stress
D11S_RS06375	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
D11S_RS06390	COG0167	dihydroorotate dehydrogenase activity
D11S_RS06395	COG0308	aminopeptidase N
D11S_RS06405	COG1448	Aminotransferase
D11S_RS06415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D11S_RS06425	COG0842	Transport permease protein
D11S_RS06435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D11S_RS06440	COG1120	ATPase activity
D11S_RS06445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D11S_RS06450	COG3585	molybdate ion transport
D11S_RS06460	COG1120	ATPase activity
D11S_RS06465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D11S_RS06470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D11S_RS06480	COG4774	siderophore transport
D11S_RS06495	COG0791	NLP P60 protein
D11S_RS06510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D11S_RS06525	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D11S_RS06525	COG0517	IMP dehydrogenase activity
D11S_RS06530	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D11S_RS06535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D11S_RS06545	COG1942	4-Oxalocrotonate Tautomerase
D11S_RS06555	COG0134	indole-3-glycerol-phosphate synthase activity
D11S_RS06555	COG0135	phosphoribosylanthranilate isomerase activity
D11S_RS06565	COG0298	carbon dioxide binding
D11S_RS06580	COG3630	sodium ion export across plasma membrane
D11S_RS06585	COG5016	pyruvate
D11S_RS06585	COG0511	ligase activity, forming carbon-carbon bonds
D11S_RS06615	COG2801	Transposase and inactivated derivatives
D11S_RS06630	COG4221	oxidoreductase activity
D11S_RS06635	COG0133	tryptophan synthase activity
D11S_RS06645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D11S_RS06655	COG0469	pyruvate kinase activity
D11S_RS06670	COG1879	ABC-type sugar transport system periplasmic component
D11S_RS06690	COG2390	Transcriptional regulator
D11S_RS06695	COG1070	Carbohydrate kinase
D11S_RS06700	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D11S_RS06705	COG1940	carbohydrate kinase activity
D11S_RS06715	COG2969	positive regulation of protein catabolic process
D11S_RS06725	COG0314	molybdopterin synthase activity
D11S_RS06730	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D11S_RS06740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D11S_RS06765	COG3005	denitrification pathway
D11S_RS06770	COG0243	molybdopterin cofactor binding
D11S_RS06775	COG2315	Protein conserved in bacteria
D11S_RS06780	COG0471	metal ion transport
D11S_RS06790	COG2026	Addiction module toxin, RelE StbE family
D11S_RS06795	COG0101	tRNA pseudouridine synthase activity
D11S_RS06815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D11S_RS06820	COG1074	ATP-dependent DNA helicase activity
D11S_RS06825	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D11S_RS06835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D11S_RS06840	COG1067	ATP-dependent peptidase activity
D11S_RS06850	COG1278	Cold shock
D11S_RS06855	COG3140	Belongs to the UPF0181 family
D11S_RS06865	COG3098	single-species biofilm formation
D11S_RS06870	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D11S_RS06875	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D11S_RS06875	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D11S_RS06920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D11S_RS06930	COG0788	formyltetrahydrofolate deformylase activity
D11S_RS06935	COG2916	Histone family protein nucleoid-structuring protein H-NS
D11S_RS06940	COG1757	Na H antiporter
D11S_RS06980	COG3161	chorismate lyase activity
D11S_RS06990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D11S_RS06995	COG1758	RNA polymerase activity
D11S_RS07005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D11S_RS07015	COG2867	negative regulation of translational initiation
D11S_RS07025	COG2850	peptidyl-arginine hydroxylation
D11S_RS07040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_RS07045	COG1137	ATPase activity
D11S_RS07050	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D11S_RS07055	COG3117	lipopolysaccharide transmembrane transporter activity
D11S_RS07060	COG1127	ABC transporter
D11S_RS07065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D11S_RS07070	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D11S_RS07075	COG2854	intermembrane phospholipid transfer
D11S_RS07080	COG3113	response to antibiotic
D11S_RS07085	COG5007	Belongs to the BolA IbaG family
D11S_RS07095	COG3691	Protein conserved in bacteria
D11S_RS07105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D11S_RS07115	COG0861	Integral membrane protein TerC family
D11S_RS07125	COG1217	gtp-binding protein TYPA
D11S_RS07145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D11S_RS07150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D11S_RS07170	COG0517	IMP dehydrogenase activity
D11S_RS07170	COG1125	glycine betaine transport
D11S_RS07175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D11S_RS07185	COG0527	aspartate kinase activity
D11S_RS07185	COG0460	homoserine dehydrogenase
D11S_RS07200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D11S_RS07205	COG2091	lysine biosynthetic process via aminoadipic acid
D11S_RS07210	COG0330	HflC and HflK could
D11S_RS07215	COG0330	HflC and HflK could
D11S_RS07220	COG1555	photosystem II stabilization
D11S_RS07225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D11S_RS07235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D11S_RS07240	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D11S_RS07245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D11S_RS07250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D11S_RS07265	COG2186	Transcriptional regulator
D11S_RS07285	COG0659	secondary active sulfate transmembrane transporter activity
D11S_RS07295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D11S_RS07310	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D11S_RS07315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D11S_RS07335	COG3115	cell septum assembly
D11S_RS07345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D11S_RS07350	COG1573	uracil-dna glycosylase
D11S_RS07355	COG0012	GTP binding
D11S_RS07360	COG0193	aminoacyl-tRNA hydrolase activity
D11S_RS07420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D11S_RS07425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D11S_RS07435	COG0024	Methionine aminopeptidase
D11S_RS07440	COG0316	Belongs to the HesB IscA family
D11S_RS07450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D11S_RS07455	COG0672	)-iron permease
D11S_RS07470	COG0577	efflux transmembrane transporter activity
D11S_RS07480	COG0577	efflux transmembrane transporter activity
D11S_RS07480	COG1136	(ABC) transporter
D11S_RS07485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D11S_RS07495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D11S_RS07500	COG3385	transposase activity
D11S_RS07520	COG1643	Atp-dependent helicase
D11S_RS07525	COG2363	Small membrane protein
D11S_RS07545	COG0247	lactate metabolic process
D11S_RS07545	COG0277	FAD linked oxidase domain protein
D11S_RS07560	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D11S_RS07565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D11S_RS07570	COG0363	glucosamine-6-phosphate deaminase activity
D11S_RS07575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D11S_RS07580	COG1737	Transcriptional regulator
D11S_RS07590	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D11S_RS07595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D11S_RS07605	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D11S_RS07610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D11S_RS07610	COG1263	PTS System
D11S_RS07610	COG2190	(PTS) system
D11S_RS07635	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D11S_RS07640	COG3683	transport system, periplasmic component
D11S_RS07645	COG0488	(ABC) transporter
D11S_RS07655	COG0187	DNA topoisomerase II activity
D11S_RS07665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D11S_RS07670	COG0625	glutathione transferase activity
D11S_RS07675	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D11S_RS07685	COG0251	oxidation-reduction process
D11S_RS07700	COG0463	Glycosyl transferase, family 2
D11S_RS07710	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D11S_RS07715	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D11S_RS07725	COG1560	Kdo2-lipid A biosynthetic process
D11S_RS07730	COG0730	response to heat
D11S_RS07735	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D11S_RS07740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D11S_RS07745	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D11S_RS07745	COG3264	Mechanosensitive ion channel
D11S_RS07750	COG0318	PFAM AMP-dependent synthetase and ligase
D11S_RS07755	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D11S_RS07760	COG0596	Alpha beta hydrolase
D11S_RS07770	COG0716	FMN binding
D11S_RS07775	COG0735	belongs to the Fur family
D11S_RS07780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D11S_RS07785	COG3094	Invasion gene expression up-regulator, SirB
D11S_RS07790	COG0023	Translation Initiation Factor
D11S_RS07800	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D11S_RS07805	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D11S_RS07810	COG0776	regulation of translation
D11S_RS07815	COG0539	negative regulation of cytoplasmic translation
D11S_RS07825	COG2990	Protein conserved in bacteria
D11S_RS07830	COG4771	TonB-dependent receptor
D11S_RS07835	COG0612	Peptidase, M16
D11S_RS07840	COG1687	branched-chain amino acid
D11S_RS07850	COG0583	DNA-binding transcription factor activity
D11S_RS07860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D11S_RS07875	COG2920	part of a sulfur-relay system
D11S_RS07885	COG1121	(ABC) transporter
D11S_RS07890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D11S_RS07895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D11S_RS07915	COG3304	Inner membrane component domain
D11S_RS07920	COG1289	transmembrane transporter activity
D11S_RS07935	COG3958	Transketolase
D11S_RS07940	COG3959	Transketolase, thiamine diphosphate binding domain
D11S_RS07965	COG0488	(ABC) transporter
D11S_RS07975	COG1346	cytolysis
D11S_RS07990	COG1525	nuclease
D11S_RS07995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D11S_RS08000	COG2166	iron-sulfur cluster assembly
D11S_RS08005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D11S_RS08005	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D11S_RS08010	COG1560	Kdo2-lipid A biosynthetic process
D11S_RS08015	COG3381	protein complex oligomerization
D11S_RS08020	COG2249	NAD(P)H dehydrogenase (quinone) activity
D11S_RS08030	COG0330	HflC and HflK could
D11S_RS08055	COG1858	cytochrome C peroxidase
D11S_RS08060	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D11S_RS08065	COG0318	PFAM AMP-dependent synthetase and ligase
D11S_RS08070	COG3065	identical protein binding
D11S_RS08075	COG1214	PFAM Peptidase M22, glycoprotease
D11S_RS08080	COG1199	ATP-dependent helicase activity
D11S_RS08085	COG0676	glucose-6-phosphate 1-epimerase activity
D11S_RS08090	COG3118	belongs to the thioredoxin family
D11S_RS08095	COG0492	ferredoxin-NADP+ reductase activity
D11S_RS08100	COG4988	ABC transporter
D11S_RS08105	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D11S_RS08115	COG0515	serine threonine protein kinase
D11S_RS08135	COG1940	carbohydrate kinase activity
D11S_RS08140	COG0671	phosphoesterase, PA-phosphatase related
D11S_RS08160	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D11S_RS08165	COG0708	Exodeoxyribonuclease III
D11S_RS08190	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D11S_RS08235	COG2951	lytic endotransglycosylase activity
D11S_RS08240	COG1216	Glycosyl transferase, family 2
D11S_RS08245	COG1216	Glycosyl transferase, family 2
D11S_RS08255	COG3306	glycosyltransferase involved in LPS biosynthesis
D11S_RS08265	COG5039	Polysaccharide pyruvyl transferase
D11S_RS08270	COG2161	toxin-antitoxin pair type II binding
D11S_RS08275	COG4115	mRNA cleavage
D11S_RS08280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D11S_RS08290	COG0210	DNA helicase
D11S_RS08295	COG2610	gluconate transmembrane transporter activity
D11S_RS08300	COG3265	gluconokinase activity
D11S_RS08305	COG1609	Transcriptional regulator
D11S_RS08330	COG0437	4 iron, 4 sulfur cluster binding
D11S_RS08335	COG2864	formate dehydrogenase
D11S_RS08340	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D11S_RS08350	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D11S_RS08360	COG0650	Formate hydrogenlyase subunit 4
D11S_RS08365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D11S_RS08370	COG4237	Hydrogenase 4 membrane
D11S_RS08375	COG0651	ATP synthesis coupled electron transport
D11S_RS08380	COG3261	NADH dehydrogenase
D11S_RS08380	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D11S_RS08385	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D11S_RS08390	COG3260	NADH ubiquinone oxidoreductase 20
D11S_RS08400	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D11S_RS08415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D11S_RS08425	COG0508	dehydrogenase complex catalyzes the overall conversion of
D11S_RS08430	COG0567	Dehydrogenase, E1 component
D11S_RS08435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D11S_RS08440	COG3108	Peptidase M15
D11S_RS08445	COG2989	Protein conserved in bacteria
D11S_RS08450	COG0793	Belongs to the peptidase S41A family
D11S_RS08460	COG2995	paraquat-inducible protein a
D11S_RS08465	COG3008	intermembrane lipid transfer
D11S_RS08475	COG3842	ATPase activity
D11S_RS08480	COG1176	ABC-type spermidine putrescine transport system, permease component I
D11S_RS08485	COG1177	transmembrane transport
D11S_RS08490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D11S_RS08505	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D11S_RS08510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D11S_RS08525	COG1522	sequence-specific DNA binding
D11S_RS08530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D11S_RS08535	COG3025	triphosphatase activity
D11S_RS08540	COG1392	Phosphate transport regulator
D11S_RS08545	COG0306	phosphate transporter
D11S_RS08550	COG4991	sh3 domain protein
D11S_RS08555	COG0617	tRNA 3'-terminal CCA addition
D11S_RS08560	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D11S_RS08565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D11S_RS08580	COG1620	l-lactate permease
D11S_RS08600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D11S_RS08610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D11S_RS08630	COG2026	Addiction module toxin, RelE StbE family
D11S_RS08645	COG0826	peptidase U32
D11S_RS08655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D11S_RS08665	COG1862	Preprotein translocase
D11S_RS08670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D11S_RS08675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D11S_RS08685	COG1012	belongs to the aldehyde dehydrogenase family
D11S_RS08685	COG1454	alcohol dehydrogenase
D11S_RS08690	COG1172	Belongs to the binding-protein-dependent transport system permease family
D11S_RS08700	COG3722	fumarate hydratase activity
D11S_RS08705	COG0246	Mannitol dehydrogenase
D11S_RS08715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D11S_RS08720	COG2274	protein secretion by the type I secretion system
D11S_RS08725	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D11S_RS08730	COG2994	toxin metabolic process
D11S_RS08740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D11S_RS08760	COG2813	Specifically methylates the guanine in position
D11S_RS08765	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
D11S_RS08770	COG0456	acetyltransferase
D11S_RS08775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D11S_RS08795	COG2165	general secretion pathway protein
D11S_RS08825	COG3064	Membrane
D11S_RS08830	COG0848	biopolymer transport protein
D11S_RS08835	COG0811	peptide transport
D11S_RS08840	COG0824	Thioesterase
D11S_RS08855	COG1294	oxidase, subunit
D11S_RS08860	COG1271	oxidase subunit
D11S_RS08885	COG0641	radical SAM
D11S_RS08890	COG0217	transcriptional regulatory protein
D11S_RS08895	COG0494	nUDIX hydrolase
D11S_RS08910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D11S_RS08915	COG1755	Isoprenylcysteine carboxyl methyltransferase
D11S_RS08960	COG2271	Major facilitator Superfamily
D11S_RS08970	COG0346	lactoylglutathione lyase activity
D11S_RS08975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D11S_RS08980	COG2056	Na+-H+ antiporter family
D11S_RS08995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D11S_RS09005	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D11S_RS09010	COG0142	geranyltranstransferase activity
D11S_RS09025	COG0697	spore germination
D11S_RS09030	COG0697	spore germination
D11S_RS09035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D11S_RS09050	COG0601	transmembrane transport
D11S_RS09055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D11S_RS09060	COG0444	Belongs to the ABC transporter superfamily
D11S_RS09065	COG4608	Belongs to the ABC transporter superfamily
D11S_RS09070	COG0745	RESPONSE REGULATOR receiver
D11S_RS09085	COG1611	Belongs to the LOG family
D11S_RS09095	COG2259	Doxx family
D11S_RS09105	COG1530	ribonuclease E activity
D11S_RS09125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D11S_RS09130	COG0626	cystathionine gamma-synthase activity
D11S_RS09185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D11S_RS09195	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D11S_RS09200	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D11S_RS09205	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D11S_RS09210	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D11S_RS09220	COG0560	Phosphoserine phosphatase
D11S_RS09235	COG0728	peptidoglycan biosynthetic process
D11S_RS09240	COG0196	riboflavin kinase activity
D11S_RS09255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D11S_RS09270	COG4974	Belongs to the 'phage' integrase family
D11S_RS09275	COG2814	Major facilitator Superfamily
D11S_RS09300	COG3061	Opacity-associated protein A
D11S_RS09300	COG3266	domain, Protein
D11S_RS09305	COG1509	lysine 2,3-aminomutase activity
D11S_RS09315	COG3033	Beta-eliminating lyase
D11S_RS09320	COG0814	amino acid
D11S_RS09325	COG2964	Protein conserved in bacteria
D11S_RS09330	COG5413	integral membrane protein
D11S_RS09340	COG0204	Acyl-transferase
D11S_RS09350	COG0697	spore germination
D11S_RS09355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D11S_RS09360	COG1882	Formate acetyltransferase
D11S_RS09365	COG2116	formate transmembrane transporter activity
D11S_RS09370	COG0537	adenosine 5'-monophosphoramidase activity
D11S_RS09405	COG3022	response to hydroperoxide
D11S_RS09410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D11S_RS09425	COG0681	Belongs to the peptidase S26 family
D11S_RS09465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D11S_RS09470	COG0592	DNA-directed DNA polymerase activity
D11S_RS09480	COG2226	methyltransferase
D11S_RS09510	COG0281	malic enzyme
D11S_RS09515	COG2081	HI0933 family
D11S_RS09520	COG3088	subunit of a heme lyase
D11S_RS09520	COG4235	cytochrome complex assembly
D11S_RS09525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D11S_RS09530	COG1138	Cytochrome C-type biogenesis protein
D11S_RS09540	COG3301	Polysulphide reductase, NrfD
D11S_RS09545	COG0437	4 iron, 4 sulfur cluster binding
D11S_RS09550	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D11S_RS09585	COG1138	Cytochrome C-type biogenesis protein
D11S_RS09595	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D11S_RS09600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D11S_RS09605	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D11S_RS09610	COG4133	protoheme IX ABC transporter activity
D11S_RS09630	COG0280	phosphate acetyltransferase
D11S_RS09630	COG0281	malic enzyme
D11S_RS09645	COG2321	neutral zinc metallopeptidase
D11S_RS09650	COG1652	LysM domain
D11S_RS09660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D11S_RS09665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D11S_RS09670	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D11S_RS09685	COG0436	Aminotransferase
D11S_RS09695	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D11S_RS09700	COG2267	carboxylic ester hydrolase activity
D11S_RS09715	COG3091	SprT-like family
D11S_RS09720	COG0814	amino acid
D11S_RS09725	COG1760	l-serine dehydratase
D11S_RS09730	COG0252	asparaginase activity
D11S_RS09740	COG3063	Type IV pilus biogenesis stability protein PilW
D11S_RS09745	COG1426	Protein conserved in bacteria
D11S_RS09760	COG2976	Protein conserved in bacteria
D11S_RS09770	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D11S_RS09775	COG2233	PERMEase
D11S_RS09780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D11S_RS09785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D11S_RS09790	COG2918	glutathione biosynthetic process
D11S_RS09790	COG1181	Belongs to the D-alanine--D-alanine ligase family
D11S_RS09795	COG2194	sulfuric ester hydrolase activity
D11S_RS09800	COG0740	serine-type endopeptidase activity
D11S_RS09820	COG3739	integral membrane protein
D11S_RS09825	COG2217	Heavy metal translocating P-type atpase
D11S_RS09830	COG2608	mercury ion transmembrane transporter activity
D11S_RS09835	COG0789	Transcriptional regulator
D11S_RS09840	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D11S_RS09850	COG1720	tRNA m6t6A37 methyltransferase activity
D11S_RS09855	COG1575	Belongs to the MenA family. Type 1 subfamily
D11S_RS09870	COG3028	Belongs to the UPF0307 family
D11S_RS09875	COG0312	modulator of DNA gyrase
D11S_RS09880	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D11S_RS09885	COG1929	Belongs to the glycerate kinase type-1 family
D11S_RS09890	COG2610	gluconate transmembrane transporter activity
D11S_RS09895	COG3835	regulator
D11S_RS09910	COG0513	Belongs to the DEAD box helicase family
D11S_RS09915	COG4785	May be involved in cell division
D11S_RS09925	COG2731	YhcH YjgK YiaL family protein
D11S_RS09930	COG3023	N-Acetylmuramoyl-L-alanine amidase
D11S_RS09935	COG4969	Belongs to the N-Me-Phe pilin family
D11S_RS09940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D11S_RS09945	COG1459	type II secretion system
D11S_RS09955	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D11S_RS09955	COG0237	dephospho-CoA kinase activity
D11S_RS09960	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D11S_RS09970	COG1115	amino acid carrier protein
D11S_RS09980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D11S_RS10010	COG2184	nucleotidyltransferase activity
D11S_RS10015	COG4145	pantothenate transmembrane transporter activity
D11S_RS10020	COG3924	membrane
D11S_RS10025	COG4783	chaperone-mediated protein folding
D11S_RS10035	COG0439	Biotin carboxylase
D11S_RS10040	COG0511	ligase activity, forming carbon-carbon bonds
D11S_RS10065	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D11S_RS10075	COG0456	acetyltransferase
D11S_RS10080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D11S_RS10090	COG3078	GTPase activator activity
D11S_RS10095	COG0590	tRNA wobble adenosine to inosine editing
D11S_RS10115	COG0730	response to heat
D11S_RS10125	COG1869	D-ribose catabolic process
D11S_RS10140	COG1879	ABC-type sugar transport system periplasmic component
D11S_RS10145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D11S_RS10150	COG1278	Cold shock
D11S_RS10185	COG0165	Argininosuccinate lyase
D11S_RS10190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D11S_RS10195	COG0753	catalase activity
D11S_RS10205	COG0587	DNA-directed DNA polymerase activity
D11S_RS10210	COG1022	Amp-dependent synthetase and ligase
D11S_RS10225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D11S_RS10225	COG1328	CTP reductase activity
D11S_RS10235	COG0602	queuosine metabolic process
D11S_RS10240	COG0084	hydrolase, TatD family'
D11S_RS10250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D11S_RS10275	COG1686	Belongs to the peptidase S11 family
D11S_RS10280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D11S_RS10280	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D11S_RS10285	COG0772	Belongs to the SEDS family
D11S_RS10290	COG0768	penicillin binding
D11S_RS10300	COG0799	negative regulation of ribosome biogenesis
D11S_RS10305	COG0513	Belongs to the DEAD box helicase family
D11S_RS10310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D11S_RS10315	COG2814	Major facilitator Superfamily
D11S_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
D11S_RS10330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D11S_RS10340	COG0416	fatty acid biosynthetic process
D11S_RS10350	COG1399	metal-binding, possibly nucleic acid-binding protein
D11S_RS10360	COG0500	methyltransferase
D11S_RS10365	COG2830	Protein of unknown function (DUF452)
D11S_RS10400	COG3392	D12 class N6 adenine-specific DNA methyltransferase
D11S_RS10470	COG5003	unkown
D11S_RS10475	COG4387	Mu-like prophage protein GP36
D11S_RS10485	COG4397	Mu-like prophage major head subunit gpT
D11S_RS10490	COG4388	Caudovirus prohead serine protease
D11S_RS10495	COG5005	Phage virion morphogenesis
D11S_RS10500	COG2369	cell adhesion
D11S_RS10505	COG4383	Mu-like prophage protein gp29
D11S_RS10510	COG4373	Mu-like prophage FluMu protein gp28
D11S_RS10520	COG0640	Transcriptional regulator
D11S_RS10550	COG3023	N-Acetylmuramoyl-L-alanine amidase
D11S_RS10555	COG5566	PFAM Mor transcription activator
D11S_RS10560	COG4382	Mu-like prophage protein Gp16
D11S_RS10675	COG2948	multi-organism process
D11S_RS10740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D11S_RS10820	COG0629	single-stranded DNA binding
D11S_RS10825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D11S_RS11000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D11S_RS11005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D11S_RS11075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D11S_RS11100	COG3468	outer membrane autotransporter barrel domain protein
D11S_RS11100	COG3266	domain, Protein
D11S_RS11225	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D11S_RS11230	COG2364	Membrane
D11S_RS11270	COG3550	peptidyl-serine autophosphorylation