locus-tag	class	description
D7S_RS00010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D7S_RS00020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D7S_RS00025	COG0314	molybdopterin synthase activity
D7S_RS00035	COG2969	positive regulation of protein catabolic process
D7S_RS00045	COG1940	carbohydrate kinase activity
D7S_RS00050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D7S_RS00055	COG1070	Carbohydrate kinase
D7S_RS00060	COG2390	Transcriptional regulator
D7S_RS00095	COG0469	pyruvate kinase activity
D7S_RS00105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7S_RS00115	COG0133	tryptophan synthase activity
D7S_RS00120	COG4221	oxidoreductase activity
D7S_RS00130	COG4771	TonB-dependent receptor
D7S_RS00130	COG1629	transport
D7S_RS00135	COG4771	TonB-dependent receptor
D7S_RS00135	COG1629	transport
D7S_RS00150	COG3630	sodium ion export across plasma membrane
D7S_RS00160	COG0298	carbon dioxide binding
D7S_RS00170	COG0135	phosphoribosylanthranilate isomerase activity
D7S_RS00170	COG0134	indole-3-glycerol-phosphate synthase activity
D7S_RS00175	COG3093	addiction module antidote protein HigA
D7S_RS00185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D7S_RS00190	COG1942	4-Oxalocrotonate Tautomerase
D7S_RS00195	COG0512	Glutamine amidotransferase of anthranilate synthase
D7S_RS00200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D7S_RS00205	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D7S_RS00210	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D7S_RS00210	COG0517	IMP dehydrogenase activity
D7S_RS00220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D7S_RS00235	COG0791	NLP P60 protein
D7S_RS00250	COG0842	Transport permease protein
D7S_RS00255	COG0842	Transport permease protein
D7S_RS00255	COG1129	ABC transporter
D7S_RS00260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7S_RS00270	COG1448	Aminotransferase
D7S_RS00275	COG0308	aminopeptidase N
D7S_RS00280	COG0167	dihydroorotate dehydrogenase activity
D7S_RS00285	COG0613	PHP domain protein
D7S_RS00295	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
D7S_RS00300	COG0589	response to stress
D7S_RS00305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D7S_RS00310	COG1528	Iron-storage protein
D7S_RS00315	COG1528	Iron-storage protein
D7S_RS00320	COG2925	Exonuclease
D7S_RS00325	COG0697	spore germination
D7S_RS00330	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D7S_RS00335	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D7S_RS00340	COG0204	Acyl-transferase
D7S_RS00340	COG0318	PFAM AMP-dependent synthetase and ligase
D7S_RS00345	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D7S_RS00350	COG1686	Belongs to the peptidase S11 family
D7S_RS00360	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D7S_RS00365	COG0586	Pfam SNARE associated Golgi protein
D7S_RS00370	COG0058	SHG alpha-glucan phosphorylase activity
D7S_RS00385	COG1523	belongs to the glycosyl hydrolase 13 family
D7S_RS00420	COG0488	(ABC) transporter
D7S_RS00425	COG3657	addiction module killer protein
D7S_RS00440	COG1346	cytolysis
D7S_RS00475	COG3293	Transposase
D7S_RS00495	COG3005	denitrification pathway
D7S_RS00500	COG0243	molybdopterin cofactor binding
D7S_RS00505	COG2315	Protein conserved in bacteria
D7S_RS00510	COG0471	metal ion transport
D7S_RS00525	COG0101	tRNA pseudouridine synthase activity
D7S_RS00545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D7S_RS00550	COG1074	ATP-dependent DNA helicase activity
D7S_RS00555	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D7S_RS00565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D7S_RS00570	COG1067	ATP-dependent peptidase activity
D7S_RS00580	COG1278	Cold shock
D7S_RS00595	COG3098	single-species biofilm formation
D7S_RS00600	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D7S_RS00650	COG3842	ATPase activity
D7S_RS00655	COG1178	ABC-type Fe3 transport system permease component
D7S_RS00660	COG3842	ATPase activity
D7S_RS00665	COG3101	peptidyl-lysine hydroxylation
D7S_RS00670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D7S_RS00680	COG0788	formyltetrahydrofolate deformylase activity
D7S_RS00685	COG2916	Histone family protein nucleoid-structuring protein H-NS
D7S_RS00690	COG1757	Na H antiporter
D7S_RS00695	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D7S_RS00705	COG0251	oxidation-reduction process
D7S_RS00720	COG0463	Glycosyl transferase, family 2
D7S_RS00730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D7S_RS00740	COG1560	Kdo2-lipid A biosynthetic process
D7S_RS00745	COG0730	response to heat
D7S_RS00750	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D7S_RS00755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D7S_RS00760	COG3264	Mechanosensitive ion channel
D7S_RS00760	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D7S_RS00765	COG0318	PFAM AMP-dependent synthetase and ligase
D7S_RS00770	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D7S_RS00775	COG0596	Alpha beta hydrolase
D7S_RS00780	COG0716	FMN binding
D7S_RS00785	COG0735	belongs to the Fur family
D7S_RS00790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7S_RS00795	COG3094	Invasion gene expression up-regulator, SirB
D7S_RS00800	COG0023	Translation Initiation Factor
D7S_RS00810	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D7S_RS00815	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D7S_RS00820	COG0776	regulation of translation
D7S_RS00825	COG0539	negative regulation of cytoplasmic translation
D7S_RS00835	COG2990	Protein conserved in bacteria
D7S_RS00840	COG4771	TonB-dependent receptor
D7S_RS00845	COG0612	Peptidase, M16
D7S_RS00850	COG1687	branched-chain amino acid
D7S_RS00855	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D7S_RS00860	COG0583	DNA-binding transcription factor activity
D7S_RS00870	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D7S_RS00875	COG1518	maintenance of DNA repeat elements
D7S_RS00920	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
D7S_RS00930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7S_RS00945	COG0405	Gamma-glutamyltransferase
D7S_RS00955	COG0745	RESPONSE REGULATOR receiver
D7S_RS00960	COG0745	RESPONSE REGULATOR receiver
D7S_RS00975	COG0737	Belongs to the 5'-nucleotidase family
D7S_RS00980	COG4607	ABC-type enterochelin transport system periplasmic component
D7S_RS00985	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7S_RS00990	COG4605	iron ion homeostasis
D7S_RS00995	COG4604	ABC transporter, ATP-binding protein
D7S_RS01000	COG0739	heme binding
D7S_RS01010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7S_RS01015	COG0733	neurotransmitter:sodium symporter activity
D7S_RS01050	COG4657	Part of a membrane complex involved in electron transport
D7S_RS01055	COG1090	epimerase
D7S_RS01060	COG1438	arginine binding
D7S_RS01065	COG0039	L-malate dehydrogenase activity
D7S_RS01075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D7S_RS01080	COG0583	DNA-binding transcription factor activity
D7S_RS01090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D7S_RS01095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D7S_RS01095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D7S_RS01100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7S_RS01110	COG0471	metal ion transport
D7S_RS01115	COG2005	Transcriptional regulator
D7S_RS01120	COG0725	ABC transporter, periplasmic molybdate-binding protein
D7S_RS01125	COG4149	molybdate abc transporter
D7S_RS01130	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D7S_RS01140	COG0795	lipopolysaccharide-transporting ATPase activity
D7S_RS01145	COG0795	lipopolysaccharide-transporting ATPase activity
D7S_RS01150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D7S_RS01155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D7S_RS01185	COG0309	Hydrogenase expression formation protein (HypE)
D7S_RS01190	COG0409	Hydrogenase expression formation protein
D7S_RS01195	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D7S_RS01200	COG1122	ATPase activity
D7S_RS01205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D7S_RS01215	COG0310	cobalt ion transport
D7S_RS01225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D7S_RS01230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D7S_RS01235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D7S_RS01240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D7S_RS01250	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D7S_RS01270	COG2271	Major facilitator Superfamily
D7S_RS01280	COG3718	enzyme involved in inositol metabolism
D7S_RS01300	COG3501	Rhs element vgr protein
D7S_RS01310	COG2949	membrane
D7S_RS01315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D7S_RS01335	COG0583	DNA-binding transcription factor activity
D7S_RS01345	COG0009	L-threonylcarbamoyladenylate synthase
D7S_RS01350	COG1605	Chorismate mutase
D7S_RS01350	COG0287	Prephenate dehydrogenase
D7S_RS01355	COG0616	signal peptide processing
D7S_RS01360	COG0778	Nitroreductase
D7S_RS01370	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7S_RS01385	COG2909	trisaccharide binding
D7S_RS01390	COG0058	SHG alpha-glucan phosphorylase activity
D7S_RS01395	COG1640	4-alpha-glucanotransferase
D7S_RS01400	COG1286	toxin biosynthetic process
D7S_RS01405	COG3092	negative regulation of chromosome organization
D7S_RS01415	COG0857	belongs to the CobB CobQ family
D7S_RS01415	COG0280	phosphate acetyltransferase
D7S_RS01425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D7S_RS01430	COG0617	tRNA 3'-terminal CCA addition
D7S_RS01435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D7S_RS01440	COG2333	competence protein COMEC
D7S_RS01440	COG0658	competence protein
D7S_RS01445	COG1132	(ABC) transporter
D7S_RS01450	COG1663	tetraacyldisaccharide 4'-kinase activity
D7S_RS01455	COG2835	tetraacyldisaccharide 4'-kinase activity
D7S_RS01465	COG0322	excinuclease ABC activity
D7S_RS01475	COG0395	ABC-type sugar transport system, permease component
D7S_RS01480	COG1175	transmembrane transport
D7S_RS01485	COG3842	ATPase activity
D7S_RS01505	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D7S_RS01510	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D7S_RS01520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D7S_RS01535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D7S_RS01550	COG0195	Participates in both transcription termination and antitermination
D7S_RS01625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D7S_RS01630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D7S_RS01640	COG0024	Methionine aminopeptidase
D7S_RS01645	COG0316	Belongs to the HesB IscA family
D7S_RS01655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7S_RS01660	COG0672	)-iron permease
D7S_RS01675	COG1136	(ABC) transporter
D7S_RS01675	COG0577	efflux transmembrane transporter activity
D7S_RS01685	COG1136	(ABC) transporter
D7S_RS01685	COG0577	efflux transmembrane transporter activity
D7S_RS01690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7S_RS01700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D7S_RS01710	COG1643	Atp-dependent helicase
D7S_RS01715	COG2363	Small membrane protein
D7S_RS01735	COG0277	FAD linked oxidase domain protein
D7S_RS01735	COG0247	lactate metabolic process
D7S_RS01750	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D7S_RS01755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D7S_RS01760	COG0363	glucosamine-6-phosphate deaminase activity
D7S_RS01765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7S_RS01770	COG1737	Transcriptional regulator
D7S_RS01780	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D7S_RS01785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D7S_RS01790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D7S_RS01790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D7S_RS01795	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D7S_RS01800	COG1263	PTS System
D7S_RS01800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7S_RS01800	COG2190	(PTS) system
D7S_RS01810	COG3501	Rhs element vgr protein
D7S_RS01825	COG3179	chitinase
D7S_RS01890	COG1940	carbohydrate kinase activity
D7S_RS01890	COG1846	Transcriptional regulator
D7S_RS01900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7S_RS01905	COG2226	methyltransferase
D7S_RS01915	COG3422	double-strand break repair
D7S_RS01925	COG1944	ATP diphosphatase activity
D7S_RS01930	COG3105	Protein conserved in bacteria
D7S_RS01935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7S_RS01955	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D7S_RS01960	COG3683	transport system, periplasmic component
D7S_RS01965	COG0488	(ABC) transporter
D7S_RS01975	COG0187	DNA topoisomerase II activity
D7S_RS01980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7S_RS01985	COG0625	glutathione transferase activity
D7S_RS01990	COG3047	cAMP biosynthetic process
D7S_RS01990	COG2885	chlorophyll binding
D7S_RS01995	COG0616	signal peptide processing
D7S_RS02015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D7S_RS02025	COG0792	nuclease activity
D7S_RS02030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D7S_RS02035	COG2823	Periplasmic or secreted lipoprotein
D7S_RS02040	COG0288	reversible hydration of carbon dioxide
D7S_RS02045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7S_RS02045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7S_RS02050	COG0785	Cytochrome C biogenesis protein
D7S_RS02055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7S_RS02070	COG2801	Transposase and inactivated derivatives
D7S_RS02080	COG3069	C4-dicarboxylate transmembrane transporter activity
D7S_RS02085	COG3077	Addiction module antitoxin, RelB DinJ family
D7S_RS02090	COG3041	Addiction module toxin RelE StbE family
D7S_RS02105	COG2351	hydroxyisourate hydrolase activity
D7S_RS02110	COG0825	malonyl-CoA metabolic process
D7S_RS02125	COG2252	PERMEase
D7S_RS02130	COG3152	Membrane
D7S_RS02135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D7S_RS02140	COG0375	protein maturation
D7S_RS02150	COG0563	adenylate kinase activity
D7S_RS02155	COG2963	transposase activity
D7S_RS02160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D7S_RS02165	COG3025	triphosphatase activity
D7S_RS02170	COG1392	Phosphate transport regulator
D7S_RS02175	COG0306	phosphate transporter
D7S_RS02180	COG4991	sh3 domain protein
D7S_RS02185	COG0617	tRNA 3'-terminal CCA addition
D7S_RS02190	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D7S_RS02195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D7S_RS02210	COG1620	l-lactate permease
D7S_RS02245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D7S_RS02255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D7S_RS02275	COG2026	Addiction module toxin, RelE StbE family
D7S_RS02290	COG0826	peptidase U32
D7S_RS02335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D7S_RS02345	COG1862	Preprotein translocase
D7S_RS02350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D7S_RS02355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D7S_RS02370	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7S_RS02375	COG1129	ABC transporter
D7S_RS02390	COG0673	inositol 2-dehydrogenase activity
D7S_RS02430	COG0720	synthase
D7S_RS02435	COG0602	queuosine metabolic process
D7S_RS02440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D7S_RS02445	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D7S_RS02455	COG0783	Belongs to the Dps family
D7S_RS02465	COG2814	Major facilitator Superfamily
D7S_RS02475	COG3550	peptidyl-serine autophosphorylation
D7S_RS02495	COG2927	DNA polymerase III (CHI subunit)
D7S_RS02500	COG0114	fumarate hydratase activity
D7S_RS02505	COG2268	Band 7 protein
D7S_RS02515	COG0778	Nitroreductase
D7S_RS02520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D7S_RS02530	COG0814	amino acid
D7S_RS02565	COG0235	Class ii aldolase
D7S_RS02570	COG3623	hexulose-6-phosphate isomerase
D7S_RS02595	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D7S_RS02625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7S_RS02630	COG3962	Belongs to the TPP enzyme family
D7S_RS02640	COG0673	inositol 2-dehydrogenase activity
D7S_RS02645	COG3722	fumarate hydratase activity
D7S_RS02650	COG0246	Mannitol dehydrogenase
D7S_RS02660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7S_RS02665	COG2274	protein secretion by the type I secretion system
D7S_RS02670	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D7S_RS02675	COG2994	toxin metabolic process
D7S_RS02685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D7S_RS02700	COG2813	Specifically methylates the guanine in position
D7S_RS02705	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
D7S_RS02715	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D7S_RS02730	COG4795	General secretion pathway protein
D7S_RS02735	COG2165	general secretion pathway protein
D7S_RS02765	COG3064	Membrane
D7S_RS02770	COG0848	biopolymer transport protein
D7S_RS02775	COG0811	peptide transport
D7S_RS02780	COG0824	Thioesterase
D7S_RS02790	COG1294	oxidase, subunit
D7S_RS02795	COG1271	oxidase subunit
D7S_RS02825	COG0217	transcriptional regulatory protein
D7S_RS02830	COG0494	nUDIX hydrolase
D7S_RS02855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D7S_RS02860	COG1755	Isoprenylcysteine carboxyl methyltransferase
D7S_RS02875	COG2271	Major facilitator Superfamily
D7S_RS02885	COG0346	lactoylglutathione lyase activity
D7S_RS02890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D7S_RS02895	COG2056	Na+-H+ antiporter family
D7S_RS02910	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D7S_RS02915	COG0142	geranyltranstransferase activity
D7S_RS02930	COG0697	spore germination
D7S_RS02935	COG0697	spore germination
D7S_RS02940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D7S_RS02950	COG4166	transmembrane transport
D7S_RS02955	COG0601	transmembrane transport
D7S_RS02960	COG0601	transmembrane transport
D7S_RS02965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7S_RS02970	COG0444	Belongs to the ABC transporter superfamily
D7S_RS02975	COG4608	Belongs to the ABC transporter superfamily
D7S_RS02980	COG0745	RESPONSE REGULATOR receiver
D7S_RS02985	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D7S_RS02995	COG1611	Belongs to the LOG family
D7S_RS03005	COG2259	Doxx family
D7S_RS03015	COG1530	ribonuclease E activity
D7S_RS03030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7S_RS03035	COG0626	cystathionine gamma-synthase activity
D7S_RS03095	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D7S_RS03100	COG1959	2 iron, 2 sulfur cluster binding
D7S_RS03110	COG0822	iron-sulfur transferase activity
D7S_RS03125	COG0443	Heat shock 70 kDa protein
D7S_RS03130	COG0633	Ferredoxin
D7S_RS03135	COG2975	iron-sulfur cluster assembly
D7S_RS03140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7S_RS03140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7S_RS03145	COG0489	protein tyrosine kinase activity
D7S_RS03150	COG3501	Rhs element vgr protein
D7S_RS03185	COG0590	tRNA wobble adenosine to inosine editing
D7S_RS03205	COG0730	response to heat
D7S_RS03215	COG1869	D-ribose catabolic process
D7S_RS03225	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7S_RS03230	COG1879	ABC-type sugar transport system periplasmic component
D7S_RS03235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7S_RS03275	COG0165	Argininosuccinate lyase
D7S_RS03280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D7S_RS03285	COG0753	catalase activity
D7S_RS03305	COG0587	DNA-directed DNA polymerase activity
D7S_RS03310	COG1022	Amp-dependent synthetase and ligase
D7S_RS03320	COG1328	CTP reductase activity
D7S_RS03320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D7S_RS03325	COG0602	queuosine metabolic process
D7S_RS03330	COG0084	hydrolase, TatD family'
D7S_RS03340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D7S_RS03395	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D7S_RS03400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D7S_RS03415	COG2960	long-chain fatty acid transporting porin activity
D7S_RS03425	COG2129	metallophosphoesterase
D7S_RS03430	COG0814	amino acid
D7S_RS03445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D7S_RS03460	COG0201	protein transport
D7S_RS03480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D7S_RS03490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D7S_RS03500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D7S_RS03525	COG0805	protein transport
D7S_RS03530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7S_RS03535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7S_RS03555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D7S_RS03560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D7S_RS03565	COG1011	Hydrolase
D7S_RS03570	COG0494	nUDIX hydrolase
D7S_RS03575	COG1917	Cupin 2, conserved barrel domain protein
D7S_RS03575	COG4977	sequence-specific DNA binding
D7S_RS03580	COG3059	membrane
D7S_RS03585	COG1297	OPT oligopeptide transporter protein
D7S_RS03595	COG1218	3'(2'),5'-bisphosphate nucleotidase
D7S_RS03600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D7S_RS03605	COG0363	glucosamine-6-phosphate deaminase activity
D7S_RS03625	COG0762	integral membrane protein
D7S_RS03635	COG0778	Nitroreductase
D7S_RS03660	COG1496	oxidoreductase activity
D7S_RS03675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D7S_RS03690	COG0006	proline dipeptidase activity
D7S_RS03715	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D7S_RS03720	COG1792	Involved in formation and maintenance of cell shape
D7S_RS03725	COG1077	Cell shape determining protein MreB Mrl
D7S_RS03730	COG0557	exoribonuclease II activity
D7S_RS03740	COG2271	Major facilitator Superfamily
D7S_RS03745	COG0584	glycerophosphoryl diester phosphodiesterase
D7S_RS03750	COG0758	DNA mediated transformation
D7S_RS03785	COG1132	(ABC) transporter
D7S_RS03790	COG4977	sequence-specific DNA binding
D7S_RS03790	COG1917	Cupin 2, conserved barrel domain protein
D7S_RS03795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7S_RS03800	COG0859	PFAM glycosyl transferase family 9
D7S_RS03815	COG1519	Transferase
D7S_RS03820	COG0463	Glycosyl transferase, family 2
D7S_RS03835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D7S_RS03840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7S_RS03845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D7S_RS03850	COG3719	Belongs to the RNase T2 family
D7S_RS03860	COG0191	fructose-bisphosphate aldolase activity
D7S_RS03865	COG3307	-O-antigen
D7S_RS03870	COG2267	carboxylic ester hydrolase activity
D7S_RS03875	COG0561	phosphatase activity
D7S_RS03880	COG0028	Belongs to the TPP enzyme family
D7S_RS03885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D7S_RS03910	COG1072	(Pantothenic acid kinase))
D7S_RS03915	COG0187	DNA topoisomerase II activity
D7S_RS03920	COG0514	ATP-dependent DNA helicase (RecQ)
D7S_RS03930	COG0019	diaminopimelate decarboxylase activity
D7S_RS03935	COG3477	response to acidic pH
D7S_RS03940	COG2818	Glycosylase
D7S_RS03945	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D7S_RS03955	COG2195	Cleaves the N-terminal amino acid of tripeptides
D7S_RS03960	COG0300	oxidoreductase activity
D7S_RS03965	COG1763	Mo-molybdopterin cofactor biosynthetic process
D7S_RS03970	COG3086	response to oxidative stress
D7S_RS03975	COG3026	antisigma factor binding
D7S_RS03980	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D7S_RS03985	COG1595	DNA-templated transcription, initiation
D7S_RS04000	COG0442	prolyl-tRNA aminoacylation
D7S_RS04005	COG1921	L-seryl-tRNASec selenium transferase activity
D7S_RS04010	COG3276	selenocysteine insertion sequence binding
D7S_RS04070	COG0521	Mo-molybdopterin cofactor biosynthetic process
D7S_RS04075	COG4589	Belongs to the CDS family
D7S_RS04085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D7S_RS04090	COG0490	domain, Protein
D7S_RS04090	COG0471	metal ion transport
D7S_RS04120	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D7S_RS04135	COG0575	Belongs to the CDS family
D7S_RS04150	COG0233	cytoplasmic translational termination
D7S_RS04165	COG4178	(ABC) transporter
D7S_RS04175	COG1349	DNA-binding transcription factor activity
D7S_RS04180	COG0705	Rhomboid family
D7S_RS04205	COG0551	DNA topoisomerase type I activity
D7S_RS04220	COG2962	Rard protein
D7S_RS04225	COG0583	DNA-binding transcription factor activity
D7S_RS04235	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D7S_RS04250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D7S_RS04255	COG1879	ABC-type sugar transport system periplasmic component
D7S_RS04260	COG1129	ABC transporter
D7S_RS04265	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7S_RS04275	COG2183	response to ionizing radiation
D7S_RS04295	COG0583	DNA-binding transcription factor activity
D7S_RS04300	COG0471	metal ion transport
D7S_RS04310	COG2183	response to ionizing radiation
D7S_RS04315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D7S_RS04325	COG1595	DNA-templated transcription, initiation
D7S_RS04335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D7S_RS04340	COG3071	HemY protein
D7S_RS04345	COG2959	enzyme of heme biosynthesis
D7S_RS04355	COG0181	hydroxymethylbilane synthase activity
D7S_RS04365	COG2197	response regulator
D7S_RS04370	COG0729	surface antigen
D7S_RS04375	COG2911	Protein conserved in bacteria
D7S_RS04380	COG0248	Ppx GppA phosphatase
D7S_RS04400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D7S_RS04405	COG3068	Protein conserved in bacteria
D7S_RS04415	COG1349	DNA-binding transcription factor activity
D7S_RS04420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D7S_RS04440	COG2272	Belongs to the type-B carboxylesterase lipase family
D7S_RS04445	COG0667	Aldo Keto reductase
D7S_RS04450	COG0656	L-ascorbic acid biosynthetic process
D7S_RS04465	COG0433	COG0433 Predicted ATPase
D7S_RS04470	COG2258	MOSC domain
D7S_RS04475	COG3012	SEC-C Motif Domain Protein
D7S_RS04485	COG1490	D-aminoacyl-tRNA deacylase activity
D7S_RS04490	COG0786	glutamate:sodium symporter activity
D7S_RS04495	COG2205	protein histidine kinase activity
D7S_RS04500	COG0745	RESPONSE REGULATOR receiver
D7S_RS04505	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D7S_RS04515	COG3082	Protein of unknown function (DUF1414)
D7S_RS04520	COG3083	sulfuric ester hydrolase activity
D7S_RS04525	COG0402	S-adenosylhomocysteine deaminase activity
D7S_RS04530	COG3956	TIGRFAM MazG family protein
D7S_RS04545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D7S_RS04555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D7S_RS04560	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D7S_RS04565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D7S_RS04580	COG0148	phosphopyruvate hydratase activity
D7S_RS04590	COG2991	Protein conserved in bacteria
D7S_RS04595	COG1477	protein flavinylation
D7S_RS04600	COG2871	sodium ion transport
D7S_RS04605	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D7S_RS04610	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D7S_RS04615	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D7S_RS04630	COG0271	Belongs to the BolA IbaG family
D7S_RS04635	COG3056	Lipoprotein
D7S_RS04660	COG1194	a g-specific adenine glycosylase
D7S_RS04670	COG3171	Protein conserved in bacteria
D7S_RS04675	COG1840	ABC-type Fe3 transport system, periplasmic component
D7S_RS04680	COG1178	ABC-type Fe3 transport system permease component
D7S_RS04685	COG3842	ATPase activity
D7S_RS04700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D7S_RS04710	COG1561	YicC-like family, N-terminal region
D7S_RS04715	COG0354	folic acid binding
D7S_RS04730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D7S_RS04740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D7S_RS04745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D7S_RS04750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D7S_RS04760	COG0500	methyltransferase
D7S_RS04765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D7S_RS04770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7S_RS04775	COG1309	transcriptional regulator
D7S_RS04780	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D7S_RS04785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D7S_RS04800	COG3306	glycosyltransferase involved in LPS biosynthesis
D7S_RS04810	COG3306	glycosyltransferase involved in LPS biosynthesis
D7S_RS04855	COG1309	transcriptional regulator
D7S_RS04870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7S_RS04875	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D7S_RS04880	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D7S_RS04885	COG4972	Pilus assembly protein
D7S_RS04905	COG4796	Type ii and iii secretion system protein
D7S_RS04920	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D7S_RS04955	COG0653	protein targeting
D7S_RS04970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D7S_RS04990	COG0789	Transcriptional regulator
D7S_RS04995	COG4701	Protein of unknown function (DUF721)
D7S_RS05010	COG0494	nUDIX hydrolase
D7S_RS05015	COG1466	dna polymerase III delta subunit
D7S_RS05020	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D7S_RS05035	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
D7S_RS05040	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
D7S_RS05045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D7S_RS05050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D7S_RS05055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D7S_RS05075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D7S_RS05080	COG4221	oxidoreductase activity
D7S_RS05085	COG0789	Transcriptional regulator
D7S_RS05090	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D7S_RS05095	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D7S_RS05100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D7S_RS05105	COG4137	Cytochrome C assembly protein
D7S_RS05120	COG0848	biopolymer transport protein
D7S_RS05130	COG4783	chaperone-mediated protein folding
D7S_RS05140	COG0814	amino acid
D7S_RS05165	COG0747	negative chemotaxis
D7S_RS05170	COG2853	Lipoprotein
D7S_RS05180	COG3501	Rhs element vgr protein
D7S_RS05200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D7S_RS05205	COG3610	response to peptide
D7S_RS05210	COG2966	Psort location CytoplasmicMembrane, score
D7S_RS05225	COG0545	Peptidyl-prolyl cis-trans isomerase
D7S_RS05230	COG0688	phosphatidylethanolamine metabolic process
D7S_RS05235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D7S_RS05245	COG2830	Protein of unknown function (DUF452)
D7S_RS05250	COG0500	methyltransferase
D7S_RS05260	COG1399	metal-binding, possibly nucleic acid-binding protein
D7S_RS05270	COG0416	fatty acid biosynthetic process
D7S_RS05280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D7S_RS05285	COG1028	Short-chain dehydrogenase reductase Sdr
D7S_RS05295	COG2814	Major facilitator Superfamily
D7S_RS05300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D7S_RS05305	COG0513	Belongs to the DEAD box helicase family
D7S_RS05310	COG0799	negative regulation of ribosome biogenesis
D7S_RS05320	COG0768	penicillin binding
D7S_RS05325	COG0772	Belongs to the SEDS family
D7S_RS05330	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D7S_RS05330	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D7S_RS05335	COG1686	Belongs to the peptidase S11 family
D7S_RS05365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7S_RS05370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7S_RS05375	COG0765	amino acid transport
D7S_RS05380	COG1126	abc transporter atp-binding protein
D7S_RS05385	COG2168	tRNA wobble position uridine thiolation
D7S_RS05395	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D7S_RS05400	COG2964	Protein conserved in bacteria
D7S_RS05405	COG0545	Peptidyl-prolyl cis-trans isomerase
D7S_RS05415	COG0678	peroxiredoxin activity
D7S_RS05415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D7S_RS05420	COG0583	DNA-binding transcription factor activity
D7S_RS05425	COG1309	transcriptional regulator
D7S_RS05430	COG1132	(ABC) transporter
D7S_RS05435	COG4988	ABC transporter
D7S_RS05440	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D7S_RS05445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D7S_RS05450	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D7S_RS05460	COG1045	serine acetyltransferase
D7S_RS05470	COG1494	fructose-1,6-bisphosphatase
D7S_RS05480	COG0716	FMN binding
D7S_RS05490	COG0702	epimerase
D7S_RS05495	COG1733	regulation of RNA biosynthetic process
D7S_RS05505	COG3312	ion transport
D7S_RS05525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D7S_RS05535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D7S_RS05550	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D7S_RS05555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D7S_RS05565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D7S_RS05575	COG1349	DNA-binding transcription factor activity
D7S_RS05610	COG3501	Rhs element vgr protein
D7S_RS05700	COG0459	protein refolding
D7S_RS05705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D7S_RS05715	COG1027	Aspartate ammonia-lyase
D7S_RS05720	COG0859	PFAM glycosyl transferase family 9
D7S_RS05725	COG3716	PTS system mannose fructose sorbose family IID component
D7S_RS05730	COG3715	PTS system
D7S_RS05735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7S_RS05735	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_RS05740	COG2814	Major facilitator Superfamily
D7S_RS05745	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D7S_RS05745	COG0662	Cupin 2, conserved barrel domain protein
D7S_RS05765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7S_RS05775	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D7S_RS05785	COG0297	glycogen (starch) synthase activity
D7S_RS05800	COG1757	Na H antiporter
D7S_RS05805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D7S_RS05810	COG4214	carbohydrate transport
D7S_RS05815	COG1129	ABC transporter
D7S_RS05820	COG4213	ABC transporter substrate-binding protein
D7S_RS05825	COG2115	Belongs to the xylose isomerase family
D7S_RS05845	COG3070	regulator of competence-specific genes
D7S_RS05850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D7S_RS05860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D7S_RS05865	COG3850	Histidine kinase
D7S_RS05870	COG3062	negative regulation of establishment of protein localization
D7S_RS05880	COG0437	4 iron, 4 sulfur cluster binding
D7S_RS05885	COG0348	domain, Protein
D7S_RS05890	COG3043	anaerobic respiration
D7S_RS05895	COG3005	denitrification pathway
D7S_RS05900	COG0754	glutathionylspermidine amidase activity
D7S_RS05905	COG0859	PFAM glycosyl transferase family 9
D7S_RS05915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7S_RS05925	COG0737	Belongs to the 5'-nucleotidase family
D7S_RS05950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7S_RS05955	COG1028	Short-chain dehydrogenase reductase Sdr
D7S_RS05965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7S_RS06020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7S_RS06045	COG1011	Hydrolase
D7S_RS06055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D7S_RS06060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D7S_RS06080	COG1596	polysaccharide export
D7S_RS06080	COG1555	photosystem II stabilization
D7S_RS06085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D7S_RS06090	COG0561	phosphatase activity
D7S_RS06095	COG1040	competence protein
D7S_RS06110	COG1114	Component of the transport system for branched-chain amino acids
D7S_RS06130	COG4804	nuclease activity
D7S_RS06140	COG4545	Glutaredoxin-related protein
D7S_RS06155	COG3381	protein complex oligomerization
D7S_RS06160	COG3302	dmso reductase anchor subunit
D7S_RS06165	COG0437	4 iron, 4 sulfur cluster binding
D7S_RS06170	COG0243	molybdopterin cofactor binding
D7S_RS06175	COG0243	molybdopterin cofactor binding
D7S_RS06185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7S_RS06185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7S_RS06195	COG5645	(Lipo)protein
D7S_RS06200	COG0210	DNA helicase
D7S_RS06225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D7S_RS06230	COG0110	maltose O-acetyltransferase activity
D7S_RS06235	COG1238	metal cluster binding
D7S_RS06315	COG3561	AntA/AntB antirepressor
D7S_RS06360	COG0582	viral genome integration into host DNA
D7S_RS06375	COG2095	MarC family integral membrane protein
D7S_RS06380	COG0488	(ABC) transporter
D7S_RS06385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D7S_RS06390	COG2137	regulation of response to DNA damage stimulus
D7S_RS06395	COG0251	oxidation-reduction process
D7S_RS06405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D7S_RS06440	COG2801	Transposase and inactivated derivatives
D7S_RS06500	COG4964	Belongs to the GSP D family
D7S_RS06530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D7S_RS06540	COG1444	tRNA N-acetyltransferase activity
D7S_RS06550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D7S_RS06560	COG1126	abc transporter atp-binding protein
D7S_RS06565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7S_RS06570	COG4215	(ABC) transporter
D7S_RS06575	COG4160	amino acid transport
D7S_RS06580	COG1966	Carbon starvation protein
D7S_RS06595	COG3116	cell division
D7S_RS06600	COG0768	penicillin binding
D7S_RS06610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D7S_RS06630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D7S_RS06645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D7S_RS06650	COG0849	cell division
D7S_RS06655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D7S_RS06665	COG1605	Chorismate mutase
D7S_RS06665	COG0077	Prephenate dehydratase
D7S_RS06670	COG0326	Molecular chaperone. Has ATPase activity
D7S_RS06675	COG1393	Belongs to the ArsC family
D7S_RS06685	COG1876	peptidase activity
D7S_RS06690	COG0494	nUDIX hydrolase
D7S_RS06695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D7S_RS06735	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D7S_RS06745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D7S_RS06750	COG1053	succinate dehydrogenase
D7S_RS06760	COG1120	ATPase activity
D7S_RS06770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7S_RS06775	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D7S_RS06780	COG1408	metallophosphoesterase
D7S_RS06790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D7S_RS06795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D7S_RS06800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D7S_RS06815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7S_RS06825	COG0741	lytic transglycosylase activity
D7S_RS06830	COG2350	Protein conserved in bacteria
D7S_RS06835	COG1607	acyl-coa hydrolase
D7S_RS06855	COG0497	DNA recombination
D7S_RS06865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D7S_RS06875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7S_RS06875	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D7S_RS06880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7S_RS06885	COG5002	protein histidine kinase activity
D7S_RS06885	COG2198	Histidine kinase
D7S_RS06885	COG0784	Response regulator, receiver
D7S_RS06890	COG4211	Belongs to the binding-protein-dependent transport system permease family
D7S_RS06900	COG1879	ABC-type sugar transport system periplasmic component
D7S_RS06905	COG1609	Transcriptional regulator
D7S_RS06910	COG1085	galactose-1-phosphate uridylyltransferase
D7S_RS06920	COG2017	converts alpha-aldose to the beta-anomer
D7S_RS06935	COG0471	metal ion transport
D7S_RS06940	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
D7S_RS06940	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D7S_RS06945	COG3051	citrate lyase alpha subunit
D7S_RS06950	COG2301	Belongs to the HpcH HpaI aldolase family
D7S_RS06960	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D7S_RS06965	COG4535	Mg2 and Co2 transporter CorC
D7S_RS06985	COG0105	UTP biosynthetic process
D7S_RS07005	COG4942	peptidase
D7S_RS07005	COG1388	LysM domain
D7S_RS07015	COG1238	metal cluster binding
D7S_RS07045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D7S_RS07060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D7S_RS07070	COG0733	neurotransmitter:sodium symporter activity
D7S_RS07080	COG1285	pathogenesis
D7S_RS07130	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D7S_RS07130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D7S_RS07130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D7S_RS07135	COG1105	Belongs to the carbohydrate kinase PfkB family
D7S_RS07140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_RS07140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_RS07150	COG0746	molybdenum cofactor guanylyltransferase activity
D7S_RS07155	COG3084	Protein conserved in bacteria
D7S_RS07160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D7S_RS07165	COG3085	chromosome segregation
D7S_RS07215	COG0561	phosphatase activity
D7S_RS07225	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D7S_RS07235	COG2610	gluconate transmembrane transporter activity
D7S_RS07240	COG3622	Belongs to the hyi family
D7S_RS07245	COG0235	Class ii aldolase
D7S_RS07250	COG3395	kinase activity
D7S_RS07255	COG2084	Dehydrogenase
D7S_RS07260	COG1349	DNA-binding transcription factor activity
D7S_RS07265	COG0347	Belongs to the P(II) protein family
D7S_RS07270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D7S_RS07275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D7S_RS07280	COG0470	DNA polymerase III
D7S_RS07285	COG0084	hydrolase, TatD family'
D7S_RS07325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7S_RS07330	COG4942	peptidase
D7S_RS07335	COG2861	carbohydrate metabolic process
D7S_RS07340	COG0606	chelatase, subunit chli
D7S_RS07350	COG2990	Protein conserved in bacteria
D7S_RS07355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D7S_RS07375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D7S_RS07430	COG0513	Belongs to the DEAD box helicase family
D7S_RS07440	COG3201	nicotinamide mononucleotide transporter
D7S_RS07455	COG3078	GTPase activator activity
D7S_RS07465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D7S_RS07470	COG0456	acetyltransferase
D7S_RS07480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D7S_RS07505	COG0511	ligase activity, forming carbon-carbon bonds
D7S_RS07510	COG0439	Biotin carboxylase
D7S_RS07520	COG4783	chaperone-mediated protein folding
D7S_RS07525	COG3924	membrane
D7S_RS07530	COG4145	pantothenate transmembrane transporter activity
D7S_RS07535	COG2184	nucleotidyltransferase activity
D7S_RS07560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D7S_RS07565	COG1115	amino acid carrier protein
D7S_RS07575	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D7S_RS07580	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D7S_RS07580	COG0237	dephospho-CoA kinase activity
D7S_RS07585	COG2801	Transposase and inactivated derivatives
D7S_RS07615	COG1181	Belongs to the D-alanine--D-alanine ligase family
D7S_RS07615	COG2918	glutathione biosynthetic process
D7S_RS07620	COG2194	sulfuric ester hydrolase activity
D7S_RS07625	COG0740	serine-type endopeptidase activity
D7S_RS07645	COG3739	integral membrane protein
D7S_RS07650	COG2217	Heavy metal translocating P-type atpase
D7S_RS07655	COG2608	mercury ion transmembrane transporter activity
D7S_RS07675	COG2932	Transcriptional regulator
D7S_RS07695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D7S_RS07715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D7S_RS07755	COG1459	type II secretion system
D7S_RS07760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D7S_RS07765	COG4969	Belongs to the N-Me-Phe pilin family
D7S_RS07770	COG3023	N-Acetylmuramoyl-L-alanine amidase
D7S_RS07775	COG2731	YhcH YjgK YiaL family protein
D7S_RS07785	COG4785	May be involved in cell division
D7S_RS07790	COG0513	Belongs to the DEAD box helicase family
D7S_RS07800	COG3835	regulator
D7S_RS07805	COG2610	gluconate transmembrane transporter activity
D7S_RS07810	COG1929	Belongs to the glycerate kinase type-1 family
D7S_RS07815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D7S_RS07820	COG0312	modulator of DNA gyrase
D7S_RS07825	COG3028	Belongs to the UPF0307 family
D7S_RS07830	COG0471	metal ion transport
D7S_RS07840	COG1575	Belongs to the MenA family. Type 1 subfamily
D7S_RS07845	COG1720	tRNA m6t6A37 methyltransferase activity
D7S_RS07875	COG2177	Part of the ABC transporter FtsEX involved in
D7S_RS07880	COG2884	Cell division ATP-binding protein ftsE
D7S_RS07885	COG0552	protein localization to endoplasmic reticulum
D7S_RS07895	COG0742	ribosomal rna small subunit methyltransferase
D7S_RS07905	COG3715	PTS system
D7S_RS07910	COG3716	PTS system mannose fructose sorbose family IID component
D7S_RS07915	COG0561	phosphatase activity
D7S_RS07920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D7S_RS07940	COG1215	transferase activity, transferring glycosyl groups
D7S_RS07950	COG2271	Major facilitator Superfamily
D7S_RS07975	COG2801	Transposase and inactivated derivatives
D7S_RS07995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D7S_RS08005	COG1758	RNA polymerase activity
D7S_RS08010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D7S_RS08020	COG3161	chorismate lyase activity
D7S_RS08060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D7S_RS08060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D7S_RS08065	COG0569	domain protein
D7S_RS08075	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D7S_RS08095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D7S_RS08100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D7S_RS08105	COG3036	rescue of stalled ribosome
D7S_RS08115	COG1393	Belongs to the ArsC family
D7S_RS08125	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D7S_RS08130	COG1522	sequence-specific DNA binding
D7S_RS08140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D7S_RS08145	COG0038	chloride channel
D7S_RS08150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D7S_RS08155	COG0549	Belongs to the carbamate kinase family
D7S_RS08160	COG1288	antiporter activity
D7S_RS08170	COG0183	Belongs to the thiolase family
D7S_RS08175	COG2031	fatty acid transporter
D7S_RS08180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D7S_RS08185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D7S_RS08190	COG0583	DNA-binding transcription factor activity
D7S_RS08195	COG0051	transcription antitermination factor activity, RNA binding
D7S_RS08200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D7S_RS08210	COG0089	rRNA binding
D7S_RS08215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D7S_RS08220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D7S_RS08225	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D7S_RS08230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D7S_RS08235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D7S_RS08240	COG0255	Belongs to the universal ribosomal protein uL29 family
D7S_RS08245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D7S_RS08275	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D7S_RS08280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D7S_RS08300	COG3115	cell septum assembly
D7S_RS08310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D7S_RS08315	COG1573	uracil-dna glycosylase
D7S_RS08320	COG0012	GTP binding
D7S_RS08325	COG0193	aminoacyl-tRNA hydrolase activity
D7S_RS08335	COG0560	Phosphoserine phosphatase
D7S_RS08350	COG0728	peptidoglycan biosynthetic process
D7S_RS08355	COG0196	riboflavin kinase activity
D7S_RS08375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D7S_RS08385	COG1555	photosystem II stabilization
D7S_RS08390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D7S_RS08400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D7S_RS08405	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D7S_RS08410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7S_RS08415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D7S_RS08420	COG0800	Aldolase
D7S_RS08430	COG1028	Short-chain dehydrogenase reductase Sdr
D7S_RS08435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7S_RS08445	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D7S_RS08460	COG2186	Transcriptional regulator
D7S_RS08480	COG0659	secondary active sulfate transmembrane transporter activity
D7S_RS08490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D7S_RS08495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D7S_RS08500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D7S_RS08505	COG2233	PERMEase
D7S_RS08510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D7S_RS08520	COG2976	Protein conserved in bacteria
D7S_RS08535	COG1426	Protein conserved in bacteria
D7S_RS08540	COG3063	Type IV pilus biogenesis stability protein PilW
D7S_RS08550	COG0252	asparaginase activity
D7S_RS08555	COG1760	l-serine dehydratase
D7S_RS08560	COG0814	amino acid
D7S_RS08565	COG3091	SprT-like family
D7S_RS08610	COG0280	phosphate acetyltransferase
D7S_RS08610	COG0281	malic enzyme
D7S_RS08625	COG2321	neutral zinc metallopeptidase
D7S_RS08630	COG1652	LysM domain
D7S_RS08640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D7S_RS08645	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D7S_RS08650	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D7S_RS08665	COG0436	Aminotransferase
D7S_RS08675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D7S_RS08680	COG2267	carboxylic ester hydrolase activity
D7S_RS08740	COG2814	Major facilitator Superfamily
D7S_RS08745	COG4133	protoheme IX ABC transporter activity
D7S_RS08750	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D7S_RS08755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D7S_RS08760	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D7S_RS08770	COG1138	Cytochrome C-type biogenesis protein
D7S_RS08805	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D7S_RS08810	COG0437	4 iron, 4 sulfur cluster binding
D7S_RS08815	COG3301	Polysulphide reductase, NrfD
D7S_RS08820	COG1138	Cytochrome C-type biogenesis protein
D7S_RS08825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7S_RS08830	COG4235	cytochrome complex assembly
D7S_RS08830	COG3088	subunit of a heme lyase
D7S_RS08835	COG2081	HI0933 family
D7S_RS08845	COG2226	methyltransferase
D7S_RS08855	COG0592	DNA-directed DNA polymerase activity
D7S_RS08860	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D7S_RS08895	COG0681	Belongs to the peptidase S26 family
D7S_RS08910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D7S_RS08950	COG0537	adenosine 5'-monophosphoramidase activity
D7S_RS08955	COG2116	formate transmembrane transporter activity
D7S_RS08960	COG1882	Formate acetyltransferase
D7S_RS08965	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D7S_RS08970	COG0697	spore germination
D7S_RS08980	COG0204	Acyl-transferase
D7S_RS08990	COG5413	integral membrane protein
D7S_RS08995	COG2964	Protein conserved in bacteria
D7S_RS09000	COG0814	amino acid
D7S_RS09005	COG3033	Beta-eliminating lyase
D7S_RS09015	COG1509	lysine 2,3-aminomutase activity
D7S_RS09020	COG3061	Opacity-associated protein A
D7S_RS09020	COG3266	domain, Protein
D7S_RS09035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D7S_RS09040	COG4974	Belongs to the 'phage' integrase family
D7S_RS09050	COG0330	HflC and HflK could
D7S_RS09055	COG0330	HflC and HflK could
D7S_RS09060	COG2091	lysine biosynthetic process via aminoadipic acid
D7S_RS09065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D7S_RS09080	COG0527	aspartate kinase activity
D7S_RS09080	COG0460	homoserine dehydrogenase
D7S_RS09090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D7S_RS09095	COG0517	IMP dehydrogenase activity
D7S_RS09095	COG1125	glycine betaine transport
D7S_RS09110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7S_RS09115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D7S_RS09120	COG3266	domain, Protein
D7S_RS09120	COG3468	outer membrane autotransporter barrel domain protein
D7S_RS09125	COG1217	gtp-binding protein TYPA
D7S_RS09135	COG0861	Integral membrane protein TerC family
D7S_RS09145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D7S_RS09155	COG3691	Protein conserved in bacteria
D7S_RS09165	COG5007	Belongs to the BolA IbaG family
D7S_RS09170	COG3113	response to antibiotic
D7S_RS09175	COG2854	intermembrane phospholipid transfer
D7S_RS09180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D7S_RS09185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7S_RS09190	COG1127	ABC transporter
D7S_RS09195	COG3117	lipopolysaccharide transmembrane transporter activity
D7S_RS09200	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D7S_RS09205	COG1137	ATPase activity
D7S_RS09210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_RS09220	COG1570	exodeoxyribonuclease VII activity
D7S_RS09225	COG2850	peptidyl-arginine hydroxylation
D7S_RS09255	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D7S_RS09260	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D7S_RS09265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D7S_RS09270	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D7S_RS09280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D7S_RS09295	COG2860	membrane
D7S_RS09320	COG1840	ABC-type Fe3 transport system, periplasmic component
D7S_RS09325	COG1840	ABC-type Fe3 transport system, periplasmic component
D7S_RS09375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7S_RS09380	COG1530	ribonuclease E activity
D7S_RS09385	COG2999	glutathione oxidoreductase activity
D7S_RS09390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D7S_RS09410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D7S_RS09415	COG0626	cystathionine gamma-synthase activity
D7S_RS09430	COG2337	Toxic component of a toxin-antitoxin (TA) module
D7S_RS09435	COG0484	heat shock protein binding
D7S_RS09440	COG0443	Heat shock 70 kDa protein
D7S_RS09450	COG3676	manually curated
D7S_RS09460	COG0725	ABC transporter, periplasmic molybdate-binding protein
D7S_RS09465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D7S_RS09470	COG3842	ATPase activity
D7S_RS09475	COG0157	Belongs to the NadC ModD family
D7S_RS09490	COG2855	membrane
D7S_RS09495	COG4953	penicillin-binding protein 1C
D7S_RS09535	COG3959	Transketolase, thiamine diphosphate binding domain
D7S_RS09540	COG3958	Transketolase
D7S_RS09555	COG1289	transmembrane transporter activity
D7S_RS09560	COG3304	Inner membrane component domain
D7S_RS09580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7S_RS09585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7S_RS09590	COG1121	(ABC) transporter
D7S_RS09600	COG2920	part of a sulfur-relay system
D7S_RS09620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D7S_RS09680	COG0351	phosphomethylpyrimidine kinase
D7S_RS09680	COG0351	phosphomethylpyrimidine kinase
D7S_RS09685	COG4143	(ABC) transporter
D7S_RS09690	COG1178	ABC-type Fe3 transport system permease component
D7S_RS09695	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D7S_RS09705	COG1522	sequence-specific DNA binding
D7S_RS09720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D7S_RS09725	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D7S_RS09740	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D7S_RS09745	COG1177	transmembrane transport
D7S_RS09750	COG1176	ABC-type spermidine putrescine transport system, permease component I
D7S_RS09755	COG3842	ATPase activity
D7S_RS09765	COG3008	intermembrane lipid transfer
D7S_RS09770	COG2995	paraquat-inducible protein a
D7S_RS09775	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D7S_RS09785	COG2989	Protein conserved in bacteria
D7S_RS09790	COG3108	Peptidase M15
D7S_RS09795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7S_RS09800	COG0567	Dehydrogenase, E1 component
D7S_RS09805	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7S_RS09815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D7S_RS09835	COG3383	formate dehydrogenase (NAD+) activity
D7S_RS09840	COG3383	formate dehydrogenase (NAD+) activity
D7S_RS09850	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D7S_RS09860	COG3260	NADH ubiquinone oxidoreductase 20
D7S_RS09870	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D7S_RS09870	COG3261	NADH dehydrogenase
D7S_RS09875	COG0651	ATP synthesis coupled electron transport
D7S_RS09880	COG4237	Hydrogenase 4 membrane
D7S_RS09885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D7S_RS09890	COG0650	Formate hydrogenlyase subunit 4
D7S_RS09895	COG0651	ATP synthesis coupled electron transport
D7S_RS09900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D7S_RS09905	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D7S_RS09910	COG2864	formate dehydrogenase
D7S_RS09915	COG0437	4 iron, 4 sulfur cluster binding
D7S_RS09930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D7S_RS09935	COG1609	Transcriptional regulator
D7S_RS09940	COG3265	gluconokinase activity
D7S_RS09945	COG2610	gluconate transmembrane transporter activity
D7S_RS09950	COG0210	DNA helicase
D7S_RS09955	COG1793	dna ligase
D7S_RS09960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D7S_RS09965	COG4115	mRNA cleavage
D7S_RS09970	COG2161	toxin-antitoxin pair type II binding
D7S_RS09975	COG5039	Polysaccharide pyruvyl transferase
D7S_RS09985	COG3306	glycosyltransferase involved in LPS biosynthesis
D7S_RS09995	COG1216	Glycosyl transferase, family 2
D7S_RS10000	COG1216	Glycosyl transferase, family 2
D7S_RS10005	COG2951	lytic endotransglycosylase activity
D7S_RS10010	COG0708	Exodeoxyribonuclease III
D7S_RS10015	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D7S_RS10020	COG1088	dTDP-glucose 4,6-dehydratase activity
D7S_RS10035	COG0671	phosphoesterase, PA-phosphatase related
D7S_RS10040	COG1940	carbohydrate kinase activity
D7S_RS10060	COG0515	serine threonine protein kinase
D7S_RS10065	COG1946	Acyl-CoA thioesterase
D7S_RS10070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D7S_RS10075	COG4988	ABC transporter
D7S_RS10080	COG0492	ferredoxin-NADP+ reductase activity
D7S_RS10085	COG3118	belongs to the thioredoxin family
D7S_RS10095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D7S_RS10100	COG0303	'Molybdopterin
D7S_RS10110	COG2027	D-alanyl-D-alanine carboxypeptidase
D7S_RS10115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D7S_RS10120	COG1534	Rna-binding protein
D7S_RS10125	COG3657	addiction module killer protein
D7S_RS10130	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D7S_RS10135	COG0307	riboflavin synthase, alpha
D7S_RS10145	COG4774	siderophore transport
D7S_RS10150	COG4178	(ABC) transporter
D7S_RS10155	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D7S_RS10160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D7S_RS10170	COG3102	Protein conserved in bacteria
D7S_RS10175	COG3133	Outer membrane lipoprotein
D7S_RS10180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D7S_RS10185	COG2890	protein-(glutamine-N5) methyltransferase activity
D7S_RS10195	COG0791	NLP P60 protein
D7S_RS10205	COG3100	YcgL domain-containing protein
D7S_RS10220	COG2062	phosphohistidine phosphatase, SixA
D7S_RS10230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D7S_RS10255	COG2932	Transcriptional regulator
D7S_RS10265	COG0516	GMP reductase activity
D7S_RS10265	COG0517	IMP dehydrogenase activity
D7S_RS10270	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D7S_RS10270	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D7S_RS10300	COG4172	Belongs to the ABC transporter superfamily
D7S_RS10305	COG4172	Belongs to the ABC transporter superfamily
D7S_RS10310	COG4171	peptide transport system, permease
D7S_RS10315	COG4168	peptide transport system, permease
D7S_RS10325	COG3106	COG3106 Predicted ATPase
D7S_RS10335	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D7S_RS10340	COG1923	regulation of RNA biosynthetic process
D7S_RS10355	COG1388	LysM domain
D7S_RS10355	COG0860	N-Acetylmuramoyl-L-alanine amidase
D7S_RS10360	COG0802	atpase or kinase
D7S_RS10375	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D7S_RS10385	COG2194	sulfuric ester hydrolase activity
D7S_RS10420	COG2337	Toxic component of a toxin-antitoxin (TA) module
D7S_RS10440	COG3021	interspecies interaction between organisms
D7S_RS10515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_RS10520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D7S_RS10525	COG2190	(PTS) system
D7S_RS10530	COG0339	signal peptide processing
D7S_RS10535	COG2832	Protein of unknown function (DUF454)
D7S_RS10565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D7S_RS10575	COG0512	Glutamine amidotransferase of anthranilate synthase
D7S_RS10580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7S_RS10620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D7S_RS10630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D7S_RS10640	COG3684	Belongs to the aldolase LacD family
D7S_RS10655	COG1063	alcohol dehydrogenase
D7S_RS10660	COG1349	DNA-binding transcription factor activity
D7S_RS10670	COG0142	geranyltranstransferase activity
D7S_RS10685	COG0285	dihydrofolate synthase activity
D7S_RS10690	COG0406	alpha-ribazole phosphatase activity
D7S_RS10695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D7S_RS10700	COG2431	L-lysine efflux transmembrane transporter activity
D7S_RS10705	COG0564	pseudouridine synthase activity
D7S_RS10715	COG2824	Alkylphosphonate utilization operon protein PhnA
D7S_RS10725	COG1538	Outer membrane efflux protein
D7S_RS10730	COG0577	efflux transmembrane transporter activity
D7S_RS10730	COG1136	(ABC) transporter
D7S_RS10735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7S_RS10785	COG4591	ABC-type transport system involved in lipoprotein release permease component
D7S_RS10790	COG1136	(ABC) transporter
D7S_RS10795	COG4591	ABC-type transport system involved in lipoprotein release permease component
D7S_RS10800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D7S_RS10805	COG0305	Participates in initiation and elongation during chromosome replication
D7S_RS10815	COG0166	Belongs to the GPI family
D7S_RS10825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D7S_RS10835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D7S_RS10840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D7S_RS10845	COG1280	lysine exporter protein (LysE YggA)
D7S_RS10855	COG0633	Ferredoxin
D7S_RS10865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7S_RS10880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7S_RS10890	COG1840	ABC-type Fe3 transport system, periplasmic component
D7S_RS10900	COG3842	ATPase activity
D7S_RS10905	COG0366	Alpha amylase catalytic
D7S_RS10910	COG3833	ABC-type maltose transport systems, permease component
D7S_RS10920	COG2182	Extracellular solute-binding protein
D7S_RS10925	COG3842	ATPase activity
D7S_RS10930	COG4580	involved in the transport of maltose and maltodextrins
D7S_RS10940	COG0676	glucose-6-phosphate 1-epimerase activity
D7S_RS10950	COG1214	PFAM Peptidase M22, glycoprotease
D7S_RS10955	COG3065	identical protein binding
D7S_RS10960	COG0318	PFAM AMP-dependent synthetase and ligase
D7S_RS10965	COG0318	PFAM AMP-dependent synthetase and ligase
D7S_RS10970	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D7S_RS10975	COG1858	cytochrome C peroxidase
D7S_RS11000	COG0330	HflC and HflK could
D7S_RS11010	COG2249	NAD(P)H dehydrogenase (quinone) activity
D7S_RS11015	COG3381	protein complex oligomerization
D7S_RS11020	COG1560	Kdo2-lipid A biosynthetic process
D7S_RS11025	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D7S_RS11025	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D7S_RS11030	COG2166	iron-sulfur cluster assembly
D7S_RS11035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7S_RS11040	COG1525	nuclease
D7S_RS11055	COG4774	siderophore transport
D7S_RS11065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D7S_RS11070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7S_RS11075	COG1120	ATPase activity
D7S_RS11090	COG3585	molybdate ion transport
D7S_RS11100	COG1120	ATPase activity
D7S_RS11105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7S_RS11180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7S_RS11180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_RS11190	COG0582	viral genome integration into host DNA
D7S_RS11205	COG3775	system Galactitol-specific IIC component