locus-tag	class	description
I6H05_RS00005	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6H05_RS00010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H05_RS00015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6H05_RS00020	COG4988	ABC transporter
I6H05_RS00025	COG1132	(ABC) transporter
I6H05_RS00030	COG1309	transcriptional regulator
I6H05_RS00035	COG0583	DNA-binding transcription factor activity
I6H05_RS00040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H05_RS00040	COG0678	peroxiredoxin activity
I6H05_RS00045	COG2900	Belongs to the SlyX family
I6H05_RS00050	COG0545	Peptidyl-prolyl cis-trans isomerase
I6H05_RS00055	COG2964	Protein conserved in bacteria
I6H05_RS00060	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6H05_RS00070	COG2168	tRNA wobble position uridine thiolation
I6H05_RS00075	COG1126	abc transporter atp-binding protein
I6H05_RS00080	COG0765	amino acid transport
I6H05_RS00085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H05_RS00090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H05_RS00105	COG2357	RelA SpoT domain protein
I6H05_RS00110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6H05_RS00120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H05_RS00130	COG1349	DNA-binding transcription factor activity
I6H05_RS00140	COG2963	transposase activity
I6H05_RS00170	COG2095	MarC family integral membrane protein
I6H05_RS00180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H05_RS00185	COG2137	regulation of response to DNA damage stimulus
I6H05_RS00190	COG0251	oxidation-reduction process
I6H05_RS00200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H05_RS00225	COG4172	Belongs to the ABC transporter superfamily
I6H05_RS00230	COG4172	Belongs to the ABC transporter superfamily
I6H05_RS00235	COG4171	peptide transport system, permease
I6H05_RS00240	COG4168	peptide transport system, permease
I6H05_RS00245	COG4166	transmembrane transport
I6H05_RS00250	COG3106	COG3106 Predicted ATPase
I6H05_RS00260	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6H05_RS00265	COG1923	regulation of RNA biosynthetic process
I6H05_RS00275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H05_RS00280	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H05_RS00280	COG1388	LysM domain
I6H05_RS00285	COG0802	atpase or kinase
I6H05_RS00295	COG2246	polysaccharide biosynthetic process
I6H05_RS00305	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6H05_RS00315	COG2194	sulfuric ester hydrolase activity
I6H05_RS00335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H05_RS00340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H05_RS00345	COG2190	(PTS) system
I6H05_RS00350	COG0339	signal peptide processing
I6H05_RS00355	COG2832	Protein of unknown function (DUF454)
I6H05_RS00360	COG4166	transmembrane transport
I6H05_RS00365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H05_RS00375	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H05_RS00380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H05_RS00385	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6H05_RS00395	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6H05_RS00400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H05_RS00405	COG0305	Participates in initiation and elongation during chromosome replication
I6H05_RS00415	COG0166	Belongs to the GPI family
I6H05_RS00420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H05_RS00430	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6H05_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6H05_RS00440	COG1280	lysine exporter protein (LysE YggA)
I6H05_RS00450	COG0633	Ferredoxin
I6H05_RS00460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H05_RS00475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H05_RS00485	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H05_RS00495	COG3842	ATPase activity
I6H05_RS00500	COG0366	Alpha amylase catalytic
I6H05_RS00505	COG3833	ABC-type maltose transport systems, permease component
I6H05_RS00515	COG2182	Extracellular solute-binding protein
I6H05_RS00520	COG3842	ATPase activity
I6H05_RS00525	COG4580	involved in the transport of maltose and maltodextrins
I6H05_RS00535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6H05_RS00540	COG0303	'Molybdopterin
I6H05_RS00550	COG2027	D-alanyl-D-alanine carboxypeptidase
I6H05_RS00555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H05_RS00560	COG1534	Rna-binding protein
I6H05_RS00565	COG3657	addiction module killer protein
I6H05_RS00570	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H05_RS00575	COG0307	riboflavin synthase, alpha
I6H05_RS00585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H05_RS00590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H05_RS00600	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6H05_RS00605	COG3842	ATPase activity
I6H05_RS00625	COG2855	membrane
I6H05_RS00630	COG4953	penicillin-binding protein 1C
I6H05_RS00635	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6H05_RS00660	COG3623	hexulose-6-phosphate isomerase
I6H05_RS00665	COG0235	Class ii aldolase
I6H05_RS00670	COG0814	amino acid
I6H05_RS00680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H05_RS00685	COG0778	Nitroreductase
I6H05_RS00700	COG2268	Band 7 protein
I6H05_RS00705	COG0114	fumarate hydratase activity
I6H05_RS00710	COG2927	DNA polymerase III (CHI subunit)
I6H05_RS00745	COG2814	Major facilitator Superfamily
I6H05_RS00750	COG1566	PFAM secretion protein HlyD family protein
I6H05_RS00755	COG0783	Belongs to the Dps family
I6H05_RS00765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6H05_RS00770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H05_RS00775	COG0602	queuosine metabolic process
I6H05_RS00780	COG0720	synthase
I6H05_RS00785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H05_RS00795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H05_RS00800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H05_RS00805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H05_RS00810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H05_RS00815	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
I6H05_RS00820	COG0310	cobalt ion transport
I6H05_RS00825	COG0310	cobalt ion transport
I6H05_RS00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6H05_RS00835	COG1122	ATPase activity
I6H05_RS00840	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6H05_RS00845	COG0409	Hydrogenase expression formation protein
I6H05_RS00875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H05_RS00880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6H05_RS00885	COG0795	lipopolysaccharide-transporting ATPase activity
I6H05_RS00890	COG0795	lipopolysaccharide-transporting ATPase activity
I6H05_RS00895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6H05_RS00900	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6H05_RS00905	COG4149	molybdate abc transporter
I6H05_RS00910	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6H05_RS00915	COG2005	Transcriptional regulator
I6H05_RS00920	COG0471	metal ion transport
I6H05_RS00930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H05_RS00935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H05_RS00935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H05_RS00940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H05_RS00950	COG0583	DNA-binding transcription factor activity
I6H05_RS00955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H05_RS00965	COG0039	L-malate dehydrogenase activity
I6H05_RS00970	COG1438	arginine binding
I6H05_RS00975	COG1090	epimerase
I6H05_RS00980	COG4657	Part of a membrane complex involved in electron transport
I6H05_RS01010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H05_RS01015	COG0733	neurotransmitter:sodium symporter activity
I6H05_RS01020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H05_RS01030	COG0739	heme binding
I6H05_RS01035	COG4604	ABC transporter, ATP-binding protein
I6H05_RS01040	COG4605	iron ion homeostasis
I6H05_RS01045	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H05_RS01050	COG4607	ABC-type enterochelin transport system periplasmic component
I6H05_RS01055	COG0737	Belongs to the 5'-nucleotidase family
I6H05_RS01065	COG3111	PFAM Bacterial OB fold (BOF) protein
I6H05_RS01100	COG0642	Histidine kinase
I6H05_RS01105	COG0405	Gamma-glutamyltransferase
I6H05_RS01120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H05_RS01125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H05_RS01130	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6H05_RS01160	COG4143	(ABC) transporter
I6H05_RS01165	COG1178	ABC-type Fe3 transport system permease component
I6H05_RS01170	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6H05_RS01180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H05_RS01185	COG3105	Protein conserved in bacteria
I6H05_RS01190	COG1944	ATP diphosphatase activity
I6H05_RS01200	COG3422	double-strand break repair
I6H05_RS01205	COG1263	PTS System
I6H05_RS01205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H05_RS01210	COG1263	PTS System
I6H05_RS01210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H05_RS01210	COG2190	(PTS) system
I6H05_RS01220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H05_RS01230	COG1940	carbohydrate kinase activity
I6H05_RS01230	COG1846	Transcriptional regulator
I6H05_RS01255	COG0563	adenylate kinase activity
I6H05_RS01260	COG2814	Major facilitator Superfamily
I6H05_RS01265	COG0375	protein maturation
I6H05_RS01270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H05_RS01275	COG3152	Membrane
I6H05_RS01280	COG2252	PERMEase
I6H05_RS01295	COG0825	malonyl-CoA metabolic process
I6H05_RS01300	COG2351	hydroxyisourate hydrolase activity
I6H05_RS01350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6H05_RS01380	COG3041	Addiction module toxin RelE StbE family
I6H05_RS01385	COG3077	Addiction module antitoxin, RelB DinJ family
I6H05_RS01390	COG3069	C4-dicarboxylate transmembrane transporter activity
I6H05_RS01405	COG0195	Participates in both transcription termination and antitermination
I6H05_RS01430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H05_RS01455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6H05_RS01460	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6H05_RS01470	COG3177	Filamentation induced by cAMP protein fic
I6H05_RS01485	COG1175	transmembrane transport
I6H05_RS01490	COG0395	ABC-type sugar transport system, permease component
I6H05_RS01500	COG0322	excinuclease ABC activity
I6H05_RS01510	COG2835	tetraacyldisaccharide 4'-kinase activity
I6H05_RS01515	COG1663	tetraacyldisaccharide 4'-kinase activity
I6H05_RS01520	COG1132	(ABC) transporter
I6H05_RS01525	COG2333	competence protein COMEC
I6H05_RS01525	COG0658	competence protein
I6H05_RS01530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6H05_RS01535	COG0617	tRNA 3'-terminal CCA addition
I6H05_RS01540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6H05_RS01550	COG0280	phosphate acetyltransferase
I6H05_RS01550	COG0857	belongs to the CobB CobQ family
I6H05_RS01555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H05_RS01560	COG3092	negative regulation of chromosome organization
I6H05_RS01565	COG1286	toxin biosynthetic process
I6H05_RS01570	COG1640	4-alpha-glucanotransferase
I6H05_RS01575	COG0058	SHG alpha-glucan phosphorylase activity
I6H05_RS01580	COG2909	trisaccharide binding
I6H05_RS01590	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6H05_RS01595	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H05_RS01600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H05_RS01605	COG0778	Nitroreductase
I6H05_RS01610	COG0616	signal peptide processing
I6H05_RS01620	COG0009	L-threonylcarbamoyladenylate synthase
I6H05_RS01630	COG0583	DNA-binding transcription factor activity
I6H05_RS01640	COG3099	Belongs to the UPF0263 family
I6H05_RS01650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H05_RS01655	COG2949	membrane
I6H05_RS01665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H05_RS01670	COG0785	Cytochrome C biogenesis protein
I6H05_RS01675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H05_RS01675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H05_RS01680	COG0288	reversible hydration of carbon dioxide
I6H05_RS01685	COG2823	Periplasmic or secreted lipoprotein
I6H05_RS01690	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6H05_RS01695	COG0792	nuclease activity
I6H05_RS01705	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6H05_RS01715	COG1252	NADH dehydrogenase
I6H05_RS01725	COG0616	signal peptide processing
I6H05_RS01730	COG3047	cAMP biosynthetic process
I6H05_RS01730	COG2885	chlorophyll binding
I6H05_RS01765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H05_RS01770	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H05_RS01780	COG3684	Belongs to the aldolase LacD family
I6H05_RS01790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H05_RS01795	COG3414	Phosphotransferase system galactitol-specific IIB component
I6H05_RS01800	COG3775	system Galactitol-specific IIC component
I6H05_RS01805	COG1063	alcohol dehydrogenase
I6H05_RS01810	COG1349	DNA-binding transcription factor activity
I6H05_RS01820	COG0142	geranyltranstransferase activity
I6H05_RS01835	COG0285	dihydrofolate synthase activity
I6H05_RS01840	COG0406	alpha-ribazole phosphatase activity
I6H05_RS01845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H05_RS01850	COG2431	L-lysine efflux transmembrane transporter activity
I6H05_RS01855	COG0564	pseudouridine synthase activity
I6H05_RS01865	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H05_RS01895	COG1538	Outer membrane efflux protein
I6H05_RS01900	COG0577	efflux transmembrane transporter activity
I6H05_RS01900	COG1136	(ABC) transporter
I6H05_RS01905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H05_RS01945	COG0058	SHG alpha-glucan phosphorylase activity
I6H05_RS01950	COG0586	Pfam SNARE associated Golgi protein
I6H05_RS01955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6H05_RS01970	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
I6H05_RS01985	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6H05_RS01990	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6H05_RS01995	COG0697	spore germination
I6H05_RS02000	COG2925	Exonuclease
I6H05_RS02010	COG2801	Transposase and inactivated derivatives
I6H05_RS02025	COG1528	Iron-storage protein
I6H05_RS02030	COG1528	Iron-storage protein
I6H05_RS02040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H05_RS02045	COG0589	response to stress
I6H05_RS02050	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
I6H05_RS02060	COG0613	PHP domain protein
I6H05_RS02065	COG0167	dihydroorotate dehydrogenase activity
I6H05_RS02070	COG0308	aminopeptidase N
I6H05_RS02075	COG1448	Aminotransferase
I6H05_RS02085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H05_RS02090	COG0842	Transport permease protein
I6H05_RS02090	COG1129	ABC transporter
I6H05_RS02095	COG0842	Transport permease protein
I6H05_RS02105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H05_RS02125	COG3423	Transcriptional regulator
I6H05_RS02140	COG1120	ATPase activity
I6H05_RS02145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H05_RS02150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H05_RS02175	COG0791	NLP P60 protein
I6H05_RS02190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6H05_RS02205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6H05_RS02205	COG0517	IMP dehydrogenase activity
I6H05_RS02210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6H05_RS02215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H05_RS02220	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H05_RS02225	COG1942	4-Oxalocrotonate Tautomerase
I6H05_RS02230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6H05_RS02240	COG3093	addiction module antidote protein HigA
I6H05_RS02250	COG0298	carbon dioxide binding
I6H05_RS02265	COG3630	sodium ion export across plasma membrane
I6H05_RS02290	COG0133	tryptophan synthase activity
I6H05_RS02300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H05_RS02310	COG0469	pyruvate kinase activity
I6H05_RS02325	COG1879	ABC-type sugar transport system periplasmic component
I6H05_RS02350	COG2390	Transcriptional regulator
I6H05_RS02355	COG1070	Carbohydrate kinase
I6H05_RS02360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6H05_RS02365	COG1940	carbohydrate kinase activity
I6H05_RS02375	COG2969	positive regulation of protein catabolic process
I6H05_RS02385	COG0314	molybdopterin synthase activity
I6H05_RS02390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6H05_RS02400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H05_RS02425	COG3005	denitrification pathway
I6H05_RS02430	COG0243	molybdopterin cofactor binding
I6H05_RS02435	COG2315	Protein conserved in bacteria
I6H05_RS02440	COG0471	metal ion transport
I6H05_RS02455	COG0101	tRNA pseudouridine synthase activity
I6H05_RS02475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H05_RS02480	COG1074	ATP-dependent DNA helicase activity
I6H05_RS02485	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6H05_RS02495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6H05_RS02500	COG1067	ATP-dependent peptidase activity
I6H05_RS02510	COG1278	Cold shock
I6H05_RS02515	COG3140	Belongs to the UPF0181 family
I6H05_RS02525	COG3098	single-species biofilm formation
I6H05_RS02530	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I6H05_RS02535	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6H05_RS02535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6H05_RS02565	COG3101	peptidyl-lysine hydroxylation
I6H05_RS02570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H05_RS02580	COG0788	formyltetrahydrofolate deformylase activity
I6H05_RS02585	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H05_RS02590	COG1757	Na H antiporter
I6H05_RS02625	COG3161	chorismate lyase activity
I6H05_RS02635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H05_RS02640	COG1758	RNA polymerase activity
I6H05_RS02650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H05_RS02660	COG2867	negative regulation of translational initiation
I6H05_RS02670	COG2850	peptidyl-arginine hydroxylation
I6H05_RS02685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H05_RS02690	COG1137	ATPase activity
I6H05_RS02695	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6H05_RS02700	COG3117	lipopolysaccharide transmembrane transporter activity
I6H05_RS02705	COG1127	ABC transporter
I6H05_RS02710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6H05_RS02715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6H05_RS02720	COG2854	intermembrane phospholipid transfer
I6H05_RS02725	COG3113	response to antibiotic
I6H05_RS02730	COG5007	Belongs to the BolA IbaG family
I6H05_RS02750	COG0463	Glycosyl transferase, family 2
I6H05_RS02760	COG3691	Protein conserved in bacteria
I6H05_RS02770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H05_RS02780	COG0861	Integral membrane protein TerC family
I6H05_RS02790	COG2801	Transposase and inactivated derivatives
I6H05_RS02800	COG1217	gtp-binding protein TYPA
I6H05_RS02810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6H05_RS02815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H05_RS02830	COG0517	IMP dehydrogenase activity
I6H05_RS02830	COG1125	glycine betaine transport
I6H05_RS02835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H05_RS02845	COG0527	aspartate kinase activity
I6H05_RS02845	COG0460	homoserine dehydrogenase
I6H05_RS02860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6H05_RS02865	COG2091	lysine biosynthetic process via aminoadipic acid
I6H05_RS02870	COG0330	HflC and HflK could
I6H05_RS02875	COG0330	HflC and HflK could
I6H05_RS02880	COG1555	photosystem II stabilization
I6H05_RS02885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6H05_RS02895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H05_RS02900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6H05_RS02905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H05_RS02910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H05_RS02915	COG0800	Aldolase
I6H05_RS02925	COG1028	Short-chain dehydrogenase reductase Sdr
I6H05_RS02930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H05_RS02940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6H05_RS02955	COG2186	Transcriptional regulator
I6H05_RS02975	COG0659	secondary active sulfate transmembrane transporter activity
I6H05_RS02985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6H05_RS03000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H05_RS03005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6H05_RS03025	COG3115	cell septum assembly
I6H05_RS03035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H05_RS03040	COG1573	uracil-dna glycosylase
I6H05_RS03045	COG0012	GTP binding
I6H05_RS03050	COG0193	aminoacyl-tRNA hydrolase activity
I6H05_RS03055	COG2801	Transposase and inactivated derivatives
I6H05_RS03115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H05_RS03120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6H05_RS03130	COG0024	Methionine aminopeptidase
I6H05_RS03135	COG0316	Belongs to the HesB IscA family
I6H05_RS03145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H05_RS03150	COG0672	)-iron permease
I6H05_RS03165	COG0577	efflux transmembrane transporter activity
I6H05_RS03175	COG1136	(ABC) transporter
I6H05_RS03175	COG0577	efflux transmembrane transporter activity
I6H05_RS03180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H05_RS03190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H05_RS03210	COG1643	Atp-dependent helicase
I6H05_RS03215	COG2363	Small membrane protein
I6H05_RS03235	COG0277	FAD linked oxidase domain protein
I6H05_RS03235	COG0247	lactate metabolic process
I6H05_RS03250	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6H05_RS03255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6H05_RS03260	COG0363	glucosamine-6-phosphate deaminase activity
I6H05_RS03265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H05_RS03270	COG1737	Transcriptional regulator
I6H05_RS03280	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6H05_RS03285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H05_RS03295	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6H05_RS03325	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6H05_RS03330	COG3683	transport system, periplasmic component
I6H05_RS03335	COG0488	(ABC) transporter
I6H05_RS03345	COG0187	DNA topoisomerase II activity
I6H05_RS03350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H05_RS03355	COG0625	glutathione transferase activity
I6H05_RS03360	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6H05_RS03370	COG0251	oxidation-reduction process
I6H05_RS03385	COG0463	Glycosyl transferase, family 2
I6H05_RS03395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H05_RS03405	COG1560	Kdo2-lipid A biosynthetic process
I6H05_RS03410	COG0730	response to heat
I6H05_RS03415	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6H05_RS03420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H05_RS03425	COG3264	Mechanosensitive ion channel
I6H05_RS03425	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6H05_RS03430	COG0318	PFAM AMP-dependent synthetase and ligase
I6H05_RS03435	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6H05_RS03440	COG0596	Alpha beta hydrolase
I6H05_RS03445	COG0716	FMN binding
I6H05_RS03450	COG0735	belongs to the Fur family
I6H05_RS03455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H05_RS03460	COG3094	Invasion gene expression up-regulator, SirB
I6H05_RS03465	COG0023	Translation Initiation Factor
I6H05_RS03475	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6H05_RS03480	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6H05_RS03485	COG0776	regulation of translation
I6H05_RS03490	COG0539	negative regulation of cytoplasmic translation
I6H05_RS03500	COG2990	Protein conserved in bacteria
I6H05_RS03505	COG4771	TonB-dependent receptor
I6H05_RS03515	COG1687	branched-chain amino acid
I6H05_RS03520	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6H05_RS03525	COG0583	DNA-binding transcription factor activity
I6H05_RS03560	COG2920	part of a sulfur-relay system
I6H05_RS03570	COG1121	(ABC) transporter
I6H05_RS03575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H05_RS03580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H05_RS03600	COG3304	Inner membrane component domain
I6H05_RS03605	COG1289	transmembrane transporter activity
I6H05_RS03620	COG3958	Transketolase
I6H05_RS03650	COG0488	(ABC) transporter
I6H05_RS03660	COG1346	cytolysis
I6H05_RS03675	COG1525	nuclease
I6H05_RS03680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H05_RS03685	COG2166	iron-sulfur cluster assembly
I6H05_RS03690	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6H05_RS03690	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6H05_RS03695	COG1560	Kdo2-lipid A biosynthetic process
I6H05_RS03700	COG3381	protein complex oligomerization
I6H05_RS03705	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6H05_RS03715	COG0330	HflC and HflK could
I6H05_RS03740	COG1858	cytochrome C peroxidase
I6H05_RS03745	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6H05_RS03750	COG0318	PFAM AMP-dependent synthetase and ligase
I6H05_RS03755	COG3065	identical protein binding
I6H05_RS03760	COG1214	PFAM Peptidase M22, glycoprotease
I6H05_RS03765	COG1199	ATP-dependent helicase activity
I6H05_RS03770	COG0676	glucose-6-phosphate 1-epimerase activity
I6H05_RS03775	COG3118	belongs to the thioredoxin family
I6H05_RS03780	COG0492	ferredoxin-NADP+ reductase activity
I6H05_RS03785	COG4988	ABC transporter
I6H05_RS03790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6H05_RS03800	COG1946	Acyl-CoA thioesterase
I6H05_RS03805	COG0515	serine threonine protein kinase
I6H05_RS03820	COG1940	carbohydrate kinase activity
I6H05_RS03825	COG0671	phosphoesterase, PA-phosphatase related
I6H05_RS03845	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6H05_RS03850	COG0708	Exodeoxyribonuclease III
I6H05_RS03875	COG1216	Glycosyl transferase, family 2
I6H05_RS03880	COG2246	polysaccharide biosynthetic process
I6H05_RS03900	COG0463	Glycosyl transferase, family 2
I6H05_RS03935	COG2951	lytic endotransglycosylase activity
I6H05_RS03940	COG1216	Glycosyl transferase, family 2
I6H05_RS03945	COG1216	Glycosyl transferase, family 2
I6H05_RS03955	COG3306	glycosyltransferase involved in LPS biosynthesis
I6H05_RS03965	COG5039	Polysaccharide pyruvyl transferase
I6H05_RS03970	COG2161	toxin-antitoxin pair type II binding
I6H05_RS03975	COG4115	mRNA cleavage
I6H05_RS03980	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6H05_RS03985	COG1793	dna ligase
I6H05_RS03990	COG0210	DNA helicase
I6H05_RS03995	COG2610	gluconate transmembrane transporter activity
I6H05_RS04000	COG3265	gluconokinase activity
I6H05_RS04005	COG1609	Transcriptional regulator
I6H05_RS04020	COG0437	4 iron, 4 sulfur cluster binding
I6H05_RS04030	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6H05_RS04035	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H05_RS04040	COG0651	ATP synthesis coupled electron transport
I6H05_RS04045	COG0650	Formate hydrogenlyase subunit 4
I6H05_RS04050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H05_RS04055	COG4237	Hydrogenase 4 membrane
I6H05_RS04060	COG0651	ATP synthesis coupled electron transport
I6H05_RS04065	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6H05_RS04065	COG3261	NADH dehydrogenase
I6H05_RS04070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H05_RS04075	COG3260	NADH ubiquinone oxidoreductase 20
I6H05_RS04085	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6H05_RS04095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6H05_RS04105	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H05_RS04110	COG0567	Dehydrogenase, E1 component
I6H05_RS04115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H05_RS04120	COG3108	Peptidase M15
I6H05_RS04125	COG2989	Protein conserved in bacteria
I6H05_RS04130	COG0793	Belongs to the peptidase S41A family
I6H05_RS04140	COG2995	paraquat-inducible protein a
I6H05_RS04145	COG3008	intermembrane lipid transfer
I6H05_RS04155	COG3842	ATPase activity
I6H05_RS04160	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6H05_RS04165	COG1177	transmembrane transport
I6H05_RS04170	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6H05_RS04185	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6H05_RS04190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H05_RS04205	COG1522	sequence-specific DNA binding
I6H05_RS04210	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6H05_RS04215	COG3025	triphosphatase activity
I6H05_RS04220	COG1392	Phosphate transport regulator
I6H05_RS04225	COG0306	phosphate transporter
I6H05_RS04230	COG4991	sh3 domain protein
I6H05_RS04235	COG0617	tRNA 3'-terminal CCA addition
I6H05_RS04240	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6H05_RS04245	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6H05_RS04265	COG1620	l-lactate permease
I6H05_RS04285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H05_RS04290	COG0328	RNA-DNA hybrid ribonuclease activity
I6H05_RS04295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H05_RS04315	COG2026	Addiction module toxin, RelE StbE family
I6H05_RS04330	COG0826	peptidase U32
I6H05_RS04340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6H05_RS04350	COG1862	Preprotein translocase
I6H05_RS04355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H05_RS04360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H05_RS04370	COG1012	belongs to the aldehyde dehydrogenase family
I6H05_RS04370	COG1454	alcohol dehydrogenase
I6H05_RS04375	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H05_RS04380	COG1129	ABC transporter
I6H05_RS04395	COG0673	inositol 2-dehydrogenase activity
I6H05_RS04405	COG2271	Major facilitator Superfamily
I6H05_RS04415	COG3718	enzyme involved in inositol metabolism
I6H05_RS04425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H05_RS04430	COG3962	Belongs to the TPP enzyme family
I6H05_RS04440	COG0673	inositol 2-dehydrogenase activity
I6H05_RS04445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H05_RS04450	COG2274	protein secretion by the type I secretion system
I6H05_RS04455	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6H05_RS04460	COG2994	toxin metabolic process
I6H05_RS04470	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H05_RS04485	COG2813	Specifically methylates the guanine in position
I6H05_RS04490	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6H05_RS04495	COG0456	acetyltransferase
I6H05_RS04500	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6H05_RS04510	COG4795	General secretion pathway protein
I6H05_RS04515	COG2165	general secretion pathway protein
I6H05_RS04545	COG3064	Membrane
I6H05_RS04550	COG0848	biopolymer transport protein
I6H05_RS04555	COG0811	peptide transport
I6H05_RS04560	COG0824	Thioesterase
I6H05_RS04575	COG1294	oxidase, subunit
I6H05_RS04580	COG1271	oxidase subunit
I6H05_RS04605	COG0641	radical SAM
I6H05_RS04610	COG0217	transcriptional regulatory protein
I6H05_RS04615	COG0494	nUDIX hydrolase
I6H05_RS04625	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H05_RS04630	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6H05_RS04645	COG2271	Major facilitator Superfamily
I6H05_RS04655	COG0346	lactoylglutathione lyase activity
I6H05_RS04660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H05_RS04665	COG2056	Na+-H+ antiporter family
I6H05_RS04680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H05_RS04690	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H05_RS04695	COG0142	geranyltranstransferase activity
I6H05_RS04710	COG0697	spore germination
I6H05_RS04715	COG0697	spore germination
I6H05_RS04720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H05_RS04740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H05_RS04745	COG0444	Belongs to the ABC transporter superfamily
I6H05_RS04750	COG4608	Belongs to the ABC transporter superfamily
I6H05_RS04755	COG0745	RESPONSE REGULATOR receiver
I6H05_RS04760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H05_RS04770	COG1611	Belongs to the LOG family
I6H05_RS04780	COG2259	Doxx family
I6H05_RS04790	COG1530	ribonuclease E activity
I6H05_RS04805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H05_RS04810	COG0626	cystathionine gamma-synthase activity
I6H05_RS04845	COG2860	membrane
I6H05_RS04860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H05_RS04870	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6H05_RS04875	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6H05_RS04880	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6H05_RS04885	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6H05_RS04895	COG0560	Phosphoserine phosphatase
I6H05_RS04910	COG0728	peptidoglycan biosynthetic process
I6H05_RS04915	COG0196	riboflavin kinase activity
I6H05_RS04930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6H05_RS04945	COG4974	Belongs to the 'phage' integrase family
I6H05_RS04950	COG2814	Major facilitator Superfamily
I6H05_RS04970	COG3061	Opacity-associated protein A
I6H05_RS04970	COG3266	domain, Protein
I6H05_RS04975	COG1509	lysine 2,3-aminomutase activity
I6H05_RS04990	COG0814	amino acid
I6H05_RS04995	COG2964	Protein conserved in bacteria
I6H05_RS05000	COG5413	integral membrane protein
I6H05_RS05010	COG0204	Acyl-transferase
I6H05_RS05020	COG0697	spore germination
I6H05_RS05025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H05_RS05030	COG1882	Formate acetyltransferase
I6H05_RS05035	COG2116	formate transmembrane transporter activity
I6H05_RS05040	COG0537	adenosine 5'-monophosphoramidase activity
I6H05_RS05075	COG3022	response to hydroperoxide
I6H05_RS05080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H05_RS05095	COG0681	Belongs to the peptidase S26 family
I6H05_RS05135	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H05_RS05140	COG0592	DNA-directed DNA polymerase activity
I6H05_RS05150	COG2226	methyltransferase
I6H05_RS05165	COG2801	Transposase and inactivated derivatives
I6H05_RS05205	COG0210	DNA helicase
I6H05_RS05235	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6H05_RS05275	COG3088	subunit of a heme lyase
I6H05_RS05275	COG4235	cytochrome complex assembly
I6H05_RS05280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H05_RS05285	COG1138	Cytochrome C-type biogenesis protein
I6H05_RS05290	COG3301	Polysulphide reductase, NrfD
I6H05_RS05295	COG0437	4 iron, 4 sulfur cluster binding
I6H05_RS05300	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6H05_RS05335	COG1138	Cytochrome C-type biogenesis protein
I6H05_RS05345	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6H05_RS05350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6H05_RS05355	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6H05_RS05360	COG4133	protoheme IX ABC transporter activity
I6H05_RS05365	COG2814	Major facilitator Superfamily
I6H05_RS05375	COG0280	phosphate acetyltransferase
I6H05_RS05375	COG0281	malic enzyme
I6H05_RS05390	COG2321	neutral zinc metallopeptidase
I6H05_RS05405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6H05_RS05410	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6H05_RS05420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6H05_RS05435	COG0436	Aminotransferase
I6H05_RS05445	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6H05_RS05450	COG2267	carboxylic ester hydrolase activity
I6H05_RS05465	COG3091	SprT-like family
I6H05_RS05470	COG0814	amino acid
I6H05_RS05475	COG1760	l-serine dehydratase
I6H05_RS05480	COG0252	asparaginase activity
I6H05_RS05490	COG3063	Type IV pilus biogenesis stability protein PilW
I6H05_RS05495	COG1426	Protein conserved in bacteria
I6H05_RS05510	COG2976	Protein conserved in bacteria
I6H05_RS05520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H05_RS05525	COG2233	PERMEase
I6H05_RS05530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H05_RS05535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H05_RS05540	COG2918	glutathione biosynthetic process
I6H05_RS05540	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H05_RS05545	COG2194	sulfuric ester hydrolase activity
I6H05_RS05550	COG0740	serine-type endopeptidase activity
I6H05_RS05570	COG3739	integral membrane protein
I6H05_RS05575	COG2217	Heavy metal translocating P-type atpase
I6H05_RS05580	COG2608	mercury ion transmembrane transporter activity
I6H05_RS05585	COG0789	Transcriptional regulator
I6H05_RS05595	COG1575	Belongs to the MenA family. Type 1 subfamily
I6H05_RS05605	COG0471	metal ion transport
I6H05_RS05610	COG3028	Belongs to the UPF0307 family
I6H05_RS05615	COG0312	modulator of DNA gyrase
I6H05_RS05620	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6H05_RS05625	COG1929	Belongs to the glycerate kinase type-1 family
I6H05_RS05630	COG2610	gluconate transmembrane transporter activity
I6H05_RS05635	COG3835	regulator
I6H05_RS05640	COG2801	Transposase and inactivated derivatives
I6H05_RS05650	COG0513	Belongs to the DEAD box helicase family
I6H05_RS05655	COG4785	May be involved in cell division
I6H05_RS05665	COG2731	YhcH YjgK YiaL family protein
I6H05_RS05670	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6H05_RS05675	COG4969	Belongs to the N-Me-Phe pilin family
I6H05_RS05680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H05_RS05685	COG1459	type II secretion system
I6H05_RS05695	COG0237	dephospho-CoA kinase activity
I6H05_RS05695	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6H05_RS05700	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6H05_RS05710	COG1115	amino acid carrier protein
I6H05_RS05715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H05_RS05740	COG2184	nucleotidyltransferase activity
I6H05_RS05745	COG4145	pantothenate transmembrane transporter activity
I6H05_RS05750	COG3924	membrane
I6H05_RS05755	COG4783	chaperone-mediated protein folding
I6H05_RS05765	COG0439	Biotin carboxylase
I6H05_RS05770	COG0511	ligase activity, forming carbon-carbon bonds
I6H05_RS05795	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6H05_RS05805	COG0456	acetyltransferase
I6H05_RS05810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H05_RS05820	COG3078	GTPase activator activity
I6H05_RS05825	COG0590	tRNA wobble adenosine to inosine editing
I6H05_RS05840	COG0730	response to heat
I6H05_RS05850	COG1869	D-ribose catabolic process
I6H05_RS05865	COG1879	ABC-type sugar transport system periplasmic component
I6H05_RS05870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H05_RS05875	COG1278	Cold shock
I6H05_RS05910	COG0165	Argininosuccinate lyase
I6H05_RS05915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H05_RS05920	COG0753	catalase activity
I6H05_RS05930	COG0587	DNA-directed DNA polymerase activity
I6H05_RS05935	COG1022	Amp-dependent synthetase and ligase
I6H05_RS05945	COG1328	CTP reductase activity
I6H05_RS05945	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H05_RS05950	COG0602	queuosine metabolic process
I6H05_RS05955	COG0084	hydrolase, TatD family'
I6H05_RS05970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6H05_RS05995	COG1686	Belongs to the peptidase S11 family
I6H05_RS06000	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6H05_RS06000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6H05_RS06005	COG0772	Belongs to the SEDS family
I6H05_RS06010	COG0768	penicillin binding
I6H05_RS06020	COG0799	negative regulation of ribosome biogenesis
I6H05_RS06025	COG0513	Belongs to the DEAD box helicase family
I6H05_RS06030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6H05_RS06035	COG2814	Major facilitator Superfamily
I6H05_RS06045	COG1028	Short-chain dehydrogenase reductase Sdr
I6H05_RS06050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6H05_RS06060	COG0416	fatty acid biosynthetic process
I6H05_RS06070	COG1399	metal-binding, possibly nucleic acid-binding protein
I6H05_RS06080	COG0500	methyltransferase
I6H05_RS06085	COG2830	Protein of unknown function (DUF452)
I6H05_RS06095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6H05_RS06100	COG0688	phosphatidylethanolamine metabolic process
I6H05_RS06105	COG0545	Peptidyl-prolyl cis-trans isomerase
I6H05_RS06115	COG2966	Psort location CytoplasmicMembrane, score
I6H05_RS06120	COG3610	response to peptide
I6H05_RS06125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H05_RS06130	COG1253	flavin adenine dinucleotide binding
I6H05_RS06140	COG0084	hydrolase, TatD family'
I6H05_RS06145	COG0470	DNA polymerase III
I6H05_RS06150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H05_RS06155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H05_RS06160	COG0347	Belongs to the P(II) protein family
I6H05_RS06165	COG1349	DNA-binding transcription factor activity
I6H05_RS06170	COG2084	Dehydrogenase
I6H05_RS06175	COG3395	kinase activity
I6H05_RS06180	COG0235	Class ii aldolase
I6H05_RS06185	COG3622	Belongs to the hyi family
I6H05_RS06195	COG0561	phosphatase activity
I6H05_RS06220	COG3085	chromosome segregation
I6H05_RS06225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H05_RS06230	COG3084	Protein conserved in bacteria
I6H05_RS06235	COG0746	molybdenum cofactor guanylyltransferase activity
I6H05_RS06245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H05_RS06245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H05_RS06250	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H05_RS06255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H05_RS06255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H05_RS06255	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6H05_RS06280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H05_RS06300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H05_RS06325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H05_RS06330	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H05_RS06335	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H05_RS06340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H05_RS06345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H05_RS06350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H05_RS06355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H05_RS06360	COG0089	rRNA binding
I6H05_RS06365	COG0088	Forms part of the polypeptide exit tunnel
I6H05_RS06370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H05_RS06375	COG0051	transcription antitermination factor activity, RNA binding
I6H05_RS06380	COG0583	DNA-binding transcription factor activity
I6H05_RS06385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6H05_RS06390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6H05_RS06395	COG2031	fatty acid transporter
I6H05_RS06400	COG0183	Belongs to the thiolase family
I6H05_RS06410	COG1288	antiporter activity
I6H05_RS06415	COG0549	Belongs to the carbamate kinase family
I6H05_RS06420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H05_RS06425	COG0038	chloride channel
I6H05_RS06430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H05_RS06440	COG1522	sequence-specific DNA binding
I6H05_RS06445	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6H05_RS06455	COG1393	Belongs to the ArsC family
I6H05_RS06465	COG3036	rescue of stalled ribosome
I6H05_RS06470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H05_RS06475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H05_RS06480	COG2841	Protein conserved in bacteria
I6H05_RS06495	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6H05_RS06505	COG0569	domain protein
I6H05_RS06510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H05_RS06510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H05_RS06550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H05_RS06570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H05_RS06575	COG2990	Protein conserved in bacteria
I6H05_RS06605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6H05_RS06625	COG3501	Rhs element vgr protein
I6H05_RS06690	COG0606	chelatase, subunit chli
I6H05_RS06695	COG2861	carbohydrate metabolic process
I6H05_RS06700	COG4942	peptidase
I6H05_RS06705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H05_RS06720	COG2853	Lipoprotein
I6H05_RS06725	COG0747	negative chemotaxis
I6H05_RS06750	COG0814	amino acid
I6H05_RS06760	COG4783	chaperone-mediated protein folding
I6H05_RS06765	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H05_RS06775	COG0552	protein localization to endoplasmic reticulum
I6H05_RS06780	COG0742	ribosomal rna small subunit methyltransferase
I6H05_RS06785	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H05_RS06785	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H05_RS06790	COG3715	PTS system
I6H05_RS06795	COG3716	PTS system mannose fructose sorbose family IID component
I6H05_RS06800	COG0561	phosphatase activity
I6H05_RS06805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6H05_RS06820	COG0726	polysaccharide deacetylase
I6H05_RS06820	COG1649	PFAM Uncharacterised BCR, COG1649
I6H05_RS06825	COG1215	transferase activity, transferring glycosyl groups
I6H05_RS06835	COG2271	Major facilitator Superfamily
I6H05_RS06865	COG0513	Belongs to the DEAD box helicase family
I6H05_RS06875	COG3201	nicotinamide mononucleotide transporter
I6H05_RS06890	COG1238	metal cluster binding
I6H05_RS06895	COG0110	maltose O-acetyltransferase activity
I6H05_RS06900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H05_RS06925	COG0210	DNA helicase
I6H05_RS06930	COG5645	(Lipo)protein
I6H05_RS06940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H05_RS06940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H05_RS06955	COG0737	Belongs to the 5'-nucleotidase family
I6H05_RS06965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H05_RS06975	COG0859	PFAM glycosyl transferase family 9
I6H05_RS06985	COG3005	denitrification pathway
I6H05_RS06990	COG3043	anaerobic respiration
I6H05_RS06995	COG0348	domain, Protein
I6H05_RS07000	COG0437	4 iron, 4 sulfur cluster binding
I6H05_RS07005	COG0243	molybdopterin cofactor binding
I6H05_RS07010	COG3062	negative regulation of establishment of protein localization
I6H05_RS07015	COG3850	Histidine kinase
I6H05_RS07020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H05_RS07030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H05_RS07035	COG3070	regulator of competence-specific genes
I6H05_RS07040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H05_RS07055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H05_RS07065	COG0583	DNA-binding transcription factor activity
I6H05_RS07070	COG2962	Rard protein
I6H05_RS07085	COG0551	DNA topoisomerase type I activity
I6H05_RS07110	COG0705	Rhomboid family
I6H05_RS07115	COG1349	DNA-binding transcription factor activity
I6H05_RS07125	COG4178	(ABC) transporter
I6H05_RS07140	COG0233	cytoplasmic translational termination
I6H05_RS07155	COG0575	Belongs to the CDS family
I6H05_RS07170	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6H05_RS07190	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6H05_RS07210	COG4589	Belongs to the CDS family
I6H05_RS07215	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H05_RS07265	COG0516	GMP reductase activity
I6H05_RS07265	COG0517	IMP dehydrogenase activity
I6H05_RS07275	COG2932	Transcriptional regulator
I6H05_RS07290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6H05_RS07300	COG2062	phosphohistidine phosphatase, SixA
I6H05_RS07315	COG3100	YcgL domain-containing protein
I6H05_RS07320	COG0791	NLP P60 protein
I6H05_RS07330	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H05_RS07335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H05_RS07340	COG3133	Outer membrane lipoprotein
I6H05_RS07345	COG3102	Protein conserved in bacteria
I6H05_RS07355	COG5339	Protein conserved in bacteria
I6H05_RS07360	COG0443	Heat shock 70 kDa protein
I6H05_RS07365	COG0484	heat shock protein binding
I6H05_RS07385	COG0626	cystathionine gamma-synthase activity
I6H05_RS07390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H05_RS07425	COG3021	interspecies interaction between organisms
I6H05_RS07450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H05_RS07455	COG2999	glutathione oxidoreductase activity
I6H05_RS07460	COG1530	ribonuclease E activity
I6H05_RS07465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H05_RS07515	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H05_RS07520	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H05_RS07545	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6H05_RS07550	COG1959	2 iron, 2 sulfur cluster binding
I6H05_RS07560	COG0822	iron-sulfur transferase activity
I6H05_RS07575	COG0443	Heat shock 70 kDa protein
I6H05_RS07580	COG0633	Ferredoxin
I6H05_RS07585	COG2975	iron-sulfur cluster assembly
I6H05_RS07590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H05_RS07590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H05_RS07595	COG0489	protein tyrosine kinase activity
I6H05_RS07605	COG0105	UTP biosynthetic process
I6H05_RS07625	COG4535	Mg2 and Co2 transporter CorC
I6H05_RS07630	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6H05_RS07640	COG2301	Belongs to the HpcH HpaI aldolase family
I6H05_RS07645	COG3051	citrate lyase alpha subunit
I6H05_RS07650	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
I6H05_RS07650	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6H05_RS07675	COG2017	converts alpha-aldose to the beta-anomer
I6H05_RS07680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H05_RS07685	COG1085	galactose-1-phosphate uridylyltransferase
I6H05_RS07690	COG1609	Transcriptional regulator
I6H05_RS07695	COG1879	ABC-type sugar transport system periplasmic component
I6H05_RS07700	COG1129	ABC transporter
I6H05_RS07705	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6H05_RS07710	COG5002	protein histidine kinase activity
I6H05_RS07710	COG2198	Histidine kinase
I6H05_RS07710	COG0784	Response regulator, receiver
I6H05_RS07715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H05_RS07730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H05_RS07740	COG0497	DNA recombination
I6H05_RS07745	COG3047	cAMP biosynthetic process
I6H05_RS07760	COG1607	acyl-coa hydrolase
I6H05_RS07765	COG2350	Protein conserved in bacteria
I6H05_RS07770	COG0741	lytic transglycosylase activity
I6H05_RS07780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H05_RS07810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H05_RS07815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H05_RS07825	COG1408	metallophosphoesterase
I6H05_RS07830	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6H05_RS07835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H05_RS07840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H05_RS07845	COG1120	ATPase activity
I6H05_RS07855	COG1053	succinate dehydrogenase
I6H05_RS07860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6H05_RS07870	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6H05_RS07910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6H05_RS07915	COG0494	nUDIX hydrolase
I6H05_RS07920	COG1876	peptidase activity
I6H05_RS07930	COG1393	Belongs to the ArsC family
I6H05_RS07935	COG0326	Molecular chaperone. Has ATPase activity
I6H05_RS07940	COG1605	Chorismate mutase
I6H05_RS07940	COG0077	Prephenate dehydratase
I6H05_RS07950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H05_RS07955	COG0849	cell division
I6H05_RS07960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6H05_RS07975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H05_RS07985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H05_RS07995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H05_RS08005	COG0768	penicillin binding
I6H05_RS08010	COG3116	cell division
I6H05_RS08025	COG1966	Carbon starvation protein
I6H05_RS08030	COG4160	amino acid transport
I6H05_RS08035	COG4215	(ABC) transporter
I6H05_RS08040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H05_RS08045	COG1126	abc transporter atp-binding protein
I6H05_RS08055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H05_RS08065	COG1444	tRNA N-acetyltransferase activity
I6H05_RS08075	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H05_RS08105	COG4964	Belongs to the GSP D family
I6H05_RS08170	COG0733	neurotransmitter:sodium symporter activity
I6H05_RS08190	COG3276	selenocysteine insertion sequence binding
I6H05_RS08195	COG1921	L-seryl-tRNASec selenium transferase activity
I6H05_RS08200	COG0442	prolyl-tRNA aminoacylation
I6H05_RS08205	COG2076	Multidrug Resistance protein
I6H05_RS08215	COG1595	DNA-templated transcription, initiation
I6H05_RS08220	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6H05_RS08225	COG3026	antisigma factor binding
I6H05_RS08230	COG3086	response to oxidative stress
I6H05_RS08235	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6H05_RS08240	COG0300	oxidoreductase activity
I6H05_RS08245	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H05_RS08255	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6H05_RS08260	COG2818	Glycosylase
I6H05_RS08265	COG3477	response to acidic pH
I6H05_RS08270	COG0019	diaminopimelate decarboxylase activity
I6H05_RS08280	COG0514	ATP-dependent DNA helicase (RecQ)
I6H05_RS08285	COG0187	DNA topoisomerase II activity
I6H05_RS08290	COG1072	(Pantothenic acid kinase))
I6H05_RS08315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H05_RS08320	COG1879	ABC-type sugar transport system periplasmic component
I6H05_RS08340	COG2183	response to ionizing radiation
I6H05_RS08345	COG0583	DNA-binding transcription factor activity
I6H05_RS08350	COG0471	metal ion transport
I6H05_RS08365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H05_RS08375	COG1595	DNA-templated transcription, initiation
I6H05_RS08385	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6H05_RS08390	COG3071	HemY protein
I6H05_RS08395	COG2959	enzyme of heme biosynthesis
I6H05_RS08405	COG0181	hydroxymethylbilane synthase activity
I6H05_RS08415	COG2197	response regulator
I6H05_RS08420	COG0729	surface antigen
I6H05_RS08425	COG2911	Protein conserved in bacteria
I6H05_RS08430	COG0248	Ppx GppA phosphatase
I6H05_RS08450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6H05_RS08455	COG3068	Protein conserved in bacteria
I6H05_RS08465	COG1349	DNA-binding transcription factor activity
I6H05_RS08470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H05_RS08505	COG0667	Aldo Keto reductase
I6H05_RS08510	COG0656	L-ascorbic acid biosynthetic process
I6H05_RS08525	COG0433	COG0433 Predicted ATPase
I6H05_RS08530	COG2258	MOSC domain
I6H05_RS08535	COG3012	SEC-C Motif Domain Protein
I6H05_RS08550	COG0786	glutamate:sodium symporter activity
I6H05_RS08555	COG2205	protein histidine kinase activity
I6H05_RS08560	COG0745	RESPONSE REGULATOR receiver
I6H05_RS08565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H05_RS08575	COG3082	Protein of unknown function (DUF1414)
I6H05_RS08580	COG3083	sulfuric ester hydrolase activity
I6H05_RS08585	COG0402	S-adenosylhomocysteine deaminase activity
I6H05_RS08590	COG3956	TIGRFAM MazG family protein
I6H05_RS08605	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6H05_RS08610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H05_RS08615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H05_RS08620	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I6H05_RS08625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H05_RS08640	COG0148	phosphopyruvate hydratase activity
I6H05_RS08650	COG2991	Protein conserved in bacteria
I6H05_RS08655	COG1477	protein flavinylation
I6H05_RS08660	COG2871	sodium ion transport
I6H05_RS08665	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6H05_RS08670	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6H05_RS08675	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6H05_RS08690	COG0271	Belongs to the BolA IbaG family
I6H05_RS08695	COG3056	Lipoprotein
I6H05_RS08720	COG1194	a g-specific adenine glycosylase
I6H05_RS08730	COG3171	Protein conserved in bacteria
I6H05_RS08735	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H05_RS08740	COG1178	ABC-type Fe3 transport system permease component
I6H05_RS08745	COG3842	ATPase activity
I6H05_RS08760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H05_RS08770	COG1561	YicC-like family, N-terminal region
I6H05_RS08775	COG0354	folic acid binding
I6H05_RS08790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H05_RS08795	COG1381	Involved in DNA repair and RecF pathway recombination
I6H05_RS08800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H05_RS08805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H05_RS08810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H05_RS08820	COG2801	Transposase and inactivated derivatives
I6H05_RS08825	COG0789	Transcriptional regulator
I6H05_RS08830	COG4701	Protein of unknown function (DUF721)
I6H05_RS08845	COG0494	nUDIX hydrolase
I6H05_RS08850	COG1466	dna polymerase III delta subunit
I6H05_RS08855	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I6H05_RS08870	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
I6H05_RS08875	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
I6H05_RS08880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6H05_RS08885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H05_RS08890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H05_RS08910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H05_RS08920	COG4221	oxidoreductase activity
I6H05_RS08930	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6H05_RS08935	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6H05_RS08940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H05_RS08945	COG4137	Cytochrome C assembly protein
I6H05_RS08950	COG4536	flavin adenine dinucleotide binding
I6H05_RS08955	COG0811	peptide transport
I6H05_RS08960	COG0848	biopolymer transport protein
I6H05_RS09005	COG0243	molybdopterin cofactor binding
I6H05_RS09010	COG0437	4 iron, 4 sulfur cluster binding
I6H05_RS09015	COG3302	dmso reductase anchor subunit
I6H05_RS09020	COG3381	protein complex oligomerization
I6H05_RS09025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H05_RS09025	COG2221	Nitrite and sulphite reductase 4Fe-4S
I6H05_RS09035	COG4545	Glutaredoxin-related protein
I6H05_RS09060	COG0805	protein transport
I6H05_RS09065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H05_RS09070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H05_RS09075	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6H05_RS09080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H05_RS09085	COG1011	Hydrolase
I6H05_RS09090	COG0494	nUDIX hydrolase
I6H05_RS09095	COG1917	Cupin 2, conserved barrel domain protein
I6H05_RS09095	COG4977	sequence-specific DNA binding
I6H05_RS09100	COG3059	membrane
I6H05_RS09105	COG1297	OPT oligopeptide transporter protein
I6H05_RS09115	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6H05_RS09120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6H05_RS09125	COG0363	glucosamine-6-phosphate deaminase activity
I6H05_RS09135	COG1794	racemase activity, acting on amino acids and derivatives
I6H05_RS09140	COG4545	Glutaredoxin-related protein
I6H05_RS09155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H05_RS09160	COG1028	Short-chain dehydrogenase reductase Sdr
I6H05_RS09170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H05_RS09225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H05_RS09250	COG1011	Hydrolase
I6H05_RS09260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6H05_RS09280	COG1596	polysaccharide export
I6H05_RS09280	COG1555	photosystem II stabilization
I6H05_RS09285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H05_RS09290	COG0561	phosphatase activity
I6H05_RS09295	COG1040	competence protein
I6H05_RS09305	COG0140	phosphoribosyl-ATP diphosphatase activity
I6H05_RS09305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6H05_RS09310	COG1114	Component of the transport system for branched-chain amino acids
I6H05_RS09335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H05_RS09345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H05_RS09355	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H05_RS09375	COG0201	protein transport
I6H05_RS09395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H05_RS09415	COG0814	amino acid
I6H05_RS09425	COG3172	ATPase kinase involved in NAD metabolism
I6H05_RS09440	COG1739	Uncharacterized protein family UPF0029
I6H05_RS09450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H05_RS09455	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6H05_RS09500	COG2801	Transposase and inactivated derivatives
I6H05_RS09515	COG0859	PFAM glycosyl transferase family 9
I6H05_RS09520	COG1027	Aspartate ammonia-lyase
I6H05_RS09530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H05_RS09535	COG0459	protein refolding
I6H05_RS09555	COG2801	Transposase and inactivated derivatives
I6H05_RS09565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H05_RS09575	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6H05_RS09590	COG4796	Type ii and iii secretion system protein
I6H05_RS09610	COG4972	Pilus assembly protein
I6H05_RS09615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6H05_RS09620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6H05_RS09625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H05_RS09640	COG1309	transcriptional regulator
I6H05_RS09650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H05_RS09665	COG2932	Transcriptional regulator
I6H05_RS09700	COG3306	glycosyltransferase involved in LPS biosynthesis
I6H05_RS09710	COG3306	glycosyltransferase involved in LPS biosynthesis
I6H05_RS09725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H05_RS09730	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6H05_RS09735	COG1309	transcriptional regulator
I6H05_RS09740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H05_RS09745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H05_RS09750	COG0500	methyltransferase
I6H05_RS09760	COG0762	integral membrane protein
I6H05_RS09770	COG0778	Nitroreductase
I6H05_RS09775	COG1368	sulfuric ester hydrolase activity
I6H05_RS09780	COG1496	oxidoreductase activity
I6H05_RS09795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H05_RS09815	COG0006	proline dipeptidase activity
I6H05_RS09840	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6H05_RS09845	COG1792	Involved in formation and maintenance of cell shape
I6H05_RS09850	COG1077	Cell shape determining protein MreB Mrl
I6H05_RS09855	COG0557	exoribonuclease II activity
I6H05_RS09865	COG2271	Major facilitator Superfamily
I6H05_RS09870	COG0584	glycerophosphoryl diester phosphodiesterase
I6H05_RS09875	COG0758	DNA mediated transformation
I6H05_RS09910	COG1132	(ABC) transporter
I6H05_RS09915	COG4977	sequence-specific DNA binding
I6H05_RS09915	COG1917	Cupin 2, conserved barrel domain protein
I6H05_RS09920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6H05_RS09925	COG0859	PFAM glycosyl transferase family 9
I6H05_RS09940	COG1519	Transferase
I6H05_RS09945	COG0463	Glycosyl transferase, family 2
I6H05_RS09955	COG1388	LysM domain
I6H05_RS09955	COG4942	peptidase
I6H05_RS09965	COG1238	metal cluster binding
I6H05_RS09995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H05_RS10005	COG2884	Cell division ATP-binding protein ftsE
I6H05_RS10010	COG2177	Part of the ABC transporter FtsEX involved in
I6H05_RS10015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H05_RS10020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H05_RS10030	COG0561	phosphatase activity
I6H05_RS10035	COG2267	carboxylic ester hydrolase activity
I6H05_RS10040	COG3307	-O-antigen
I6H05_RS10045	COG0191	fructose-bisphosphate aldolase activity
I6H05_RS10055	COG3719	Belongs to the RNase T2 family
I6H05_RS10060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H05_RS10065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H05_RS10070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H05_RS10075	COG2801	Transposase and inactivated derivatives
I6H05_RS10090	COG0582	viral genome integration into host DNA
I6H05_RS10100	COG1070	Carbohydrate kinase
I6H05_RS10105	COG2115	Belongs to the xylose isomerase family
I6H05_RS10110	COG4213	ABC transporter substrate-binding protein
I6H05_RS10115	COG1129	ABC transporter
I6H05_RS10120	COG4214	carbohydrate transport
I6H05_RS10125	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6H05_RS10130	COG1757	Na H antiporter
I6H05_RS10135	COG2207	Transcriptional regulator
I6H05_RS10135	COG1609	Transcriptional regulator
I6H05_RS10140	COG2814	Major facilitator Superfamily
I6H05_RS10145	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H05_RS10145	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H05_RS10150	COG3715	PTS system
I6H05_RS10155	COG3716	PTS system mannose fructose sorbose family IID component
I6H05_RS10165	COG0732	type I restriction modification DNA specificity domain
I6H05_RS10185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6H05_RS10200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6H05_RS10210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H05_RS10230	COG3312	ion transport
I6H05_RS10240	COG1733	regulation of RNA biosynthetic process
I6H05_RS10245	COG0702	epimerase
I6H05_RS10255	COG0716	FMN binding
I6H05_RS10265	COG1494	fructose-1,6-bisphosphatase
I6H05_RS10270	COG1045	serine acetyltransferase