locus-tag	class	description
HK1651_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HK1651_RS00010	COG0592	DNA-directed DNA polymerase activity
HK1651_RS00020	COG2226	methyltransferase
HK1651_RS00050	COG0281	malic enzyme
HK1651_RS00080	COG0210	DNA helicase
HK1651_RS00110	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HK1651_RS00145	COG2081	HI0933 family
HK1651_RS00150	COG3088	subunit of a heme lyase
HK1651_RS00150	COG4235	cytochrome complex assembly
HK1651_RS00155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HK1651_RS00160	COG1138	Cytochrome C-type biogenesis protein
HK1651_RS00165	COG3301	Polysulphide reductase, NrfD
HK1651_RS00170	COG0437	4 iron, 4 sulfur cluster binding
HK1651_RS00175	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HK1651_RS00210	COG1138	Cytochrome C-type biogenesis protein
HK1651_RS00220	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HK1651_RS00225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HK1651_RS00230	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HK1651_RS00235	COG4133	protoheme IX ABC transporter activity
HK1651_RS00240	COG2814	Major facilitator Superfamily
HK1651_RS00250	COG0281	malic enzyme
HK1651_RS00250	COG0280	phosphate acetyltransferase
HK1651_RS00265	COG2321	neutral zinc metallopeptidase
HK1651_RS00280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HK1651_RS00285	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HK1651_RS00290	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HK1651_RS00305	COG0436	Aminotransferase
HK1651_RS00315	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HK1651_RS00320	COG2267	carboxylic ester hydrolase activity
HK1651_RS00335	COG3091	SprT-like family
HK1651_RS00340	COG0814	amino acid
HK1651_RS00345	COG1760	l-serine dehydratase
HK1651_RS00350	COG0252	asparaginase activity
HK1651_RS00360	COG3063	Type IV pilus biogenesis stability protein PilW
HK1651_RS00365	COG1426	Protein conserved in bacteria
HK1651_RS00380	COG2976	Protein conserved in bacteria
HK1651_RS00390	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HK1651_RS00395	COG2233	PERMEase
HK1651_RS00400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HK1651_RS00405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HK1651_RS00410	COG2918	glutathione biosynthetic process
HK1651_RS00410	COG1181	Belongs to the D-alanine--D-alanine ligase family
HK1651_RS00415	COG2194	sulfuric ester hydrolase activity
HK1651_RS00420	COG0740	serine-type endopeptidase activity
HK1651_RS00440	COG3739	integral membrane protein
HK1651_RS00445	COG2217	Heavy metal translocating P-type atpase
HK1651_RS00450	COG2608	mercury ion transmembrane transporter activity
HK1651_RS00455	COG0789	Transcriptional regulator
HK1651_RS00460	COG1720	tRNA m6t6A37 methyltransferase activity
HK1651_RS00465	COG1575	Belongs to the MenA family. Type 1 subfamily
HK1651_RS00475	COG0471	metal ion transport
HK1651_RS00480	COG3028	Belongs to the UPF0307 family
HK1651_RS00485	COG0312	modulator of DNA gyrase
HK1651_RS00490	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HK1651_RS00495	COG1929	Belongs to the glycerate kinase type-1 family
HK1651_RS00500	COG2610	gluconate transmembrane transporter activity
HK1651_RS00505	COG3835	regulator
HK1651_RS00515	COG0513	Belongs to the DEAD box helicase family
HK1651_RS00520	COG4785	May be involved in cell division
HK1651_RS00530	COG2731	YhcH YjgK YiaL family protein
HK1651_RS00535	COG3023	N-Acetylmuramoyl-L-alanine amidase
HK1651_RS00540	COG4969	Belongs to the N-Me-Phe pilin family
HK1651_RS00550	COG1459	type II secretion system
HK1651_RS00560	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HK1651_RS00560	COG0237	dephospho-CoA kinase activity
HK1651_RS00565	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HK1651_RS00575	COG1115	amino acid carrier protein
HK1651_RS00580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HK1651_RS00605	COG2184	nucleotidyltransferase activity
HK1651_RS00610	COG4145	pantothenate transmembrane transporter activity
HK1651_RS00615	COG3924	membrane
HK1651_RS00620	COG4783	chaperone-mediated protein folding
HK1651_RS00630	COG0439	Biotin carboxylase
HK1651_RS00635	COG0511	ligase activity, forming carbon-carbon bonds
HK1651_RS00660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HK1651_RS00670	COG0456	acetyltransferase
HK1651_RS00675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HK1651_RS00685	COG3078	GTPase activator activity
HK1651_RS00690	COG0590	tRNA wobble adenosine to inosine editing
HK1651_RS00710	COG0730	response to heat
HK1651_RS00730	COG1172	Belongs to the binding-protein-dependent transport system permease family
HK1651_RS00735	COG1879	ABC-type sugar transport system periplasmic component
HK1651_RS00740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HK1651_RS00745	COG1278	Cold shock
HK1651_RS00780	COG0165	Argininosuccinate lyase
HK1651_RS00785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HK1651_RS00790	COG0753	catalase activity
HK1651_RS00795	COG0587	DNA-directed DNA polymerase activity
HK1651_RS00800	COG1022	Amp-dependent synthetase and ligase
HK1651_RS00815	COG1328	CTP reductase activity
HK1651_RS00815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HK1651_RS00820	COG0602	queuosine metabolic process
HK1651_RS00825	COG0084	hydrolase, TatD family'
HK1651_RS00835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HK1651_RS00860	COG1686	Belongs to the peptidase S11 family
HK1651_RS00865	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HK1651_RS00865	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HK1651_RS00870	COG0772	Belongs to the SEDS family
HK1651_RS00875	COG0768	penicillin binding
HK1651_RS00885	COG0799	negative regulation of ribosome biogenesis
HK1651_RS00890	COG0513	Belongs to the DEAD box helicase family
HK1651_RS00895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HK1651_RS00900	COG2814	Major facilitator Superfamily
HK1651_RS00910	COG1028	Short-chain dehydrogenase reductase Sdr
HK1651_RS00915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HK1651_RS00925	COG0416	fatty acid biosynthetic process
HK1651_RS00935	COG1399	metal-binding, possibly nucleic acid-binding protein
HK1651_RS00945	COG0500	methyltransferase
HK1651_RS00950	COG2830	Protein of unknown function (DUF452)
HK1651_RS00960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HK1651_RS00965	COG0688	phosphatidylethanolamine metabolic process
HK1651_RS00970	COG0545	Peptidyl-prolyl cis-trans isomerase
HK1651_RS00990	COG2966	Psort location CytoplasmicMembrane, score
HK1651_RS00995	COG3610	response to peptide
HK1651_RS01000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HK1651_RS01005	COG1253	flavin adenine dinucleotide binding
HK1651_RS01015	COG0084	hydrolase, TatD family'
HK1651_RS01020	COG0470	DNA polymerase III
HK1651_RS01025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HK1651_RS01030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HK1651_RS01035	COG0347	Belongs to the P(II) protein family
HK1651_RS01040	COG1349	DNA-binding transcription factor activity
HK1651_RS01045	COG2084	Dehydrogenase
HK1651_RS01050	COG3395	kinase activity
HK1651_RS01055	COG0235	Class ii aldolase
HK1651_RS01060	COG3622	Belongs to the hyi family
HK1651_RS01070	COG0561	phosphatase activity
HK1651_RS01095	COG3085	chromosome segregation
HK1651_RS01100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HK1651_RS01105	COG3084	Protein conserved in bacteria
HK1651_RS01110	COG0746	molybdenum cofactor guanylyltransferase activity
HK1651_RS01120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HK1651_RS01120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HK1651_RS01125	COG1105	Belongs to the carbohydrate kinase PfkB family
HK1651_RS01130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HK1651_RS01130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HK1651_RS01130	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HK1651_RS01155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HK1651_RS01175	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HK1651_RS01200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HK1651_RS01205	COG0255	Belongs to the universal ribosomal protein uL29 family
HK1651_RS01210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HK1651_RS01215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HK1651_RS01220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HK1651_RS01225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HK1651_RS01230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HK1651_RS01235	COG0089	rRNA binding
HK1651_RS01240	COG0088	Forms part of the polypeptide exit tunnel
HK1651_RS01245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HK1651_RS01250	COG0051	transcription antitermination factor activity, RNA binding
HK1651_RS01255	COG0583	DNA-binding transcription factor activity
HK1651_RS01260	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HK1651_RS01265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HK1651_RS01270	COG2031	fatty acid transporter
HK1651_RS01275	COG0183	Belongs to the thiolase family
HK1651_RS01285	COG1288	antiporter activity
HK1651_RS01290	COG0549	Belongs to the carbamate kinase family
HK1651_RS01295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HK1651_RS01300	COG0038	chloride channel
HK1651_RS01305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HK1651_RS01315	COG1522	sequence-specific DNA binding
HK1651_RS01320	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HK1651_RS01330	COG1393	Belongs to the ArsC family
HK1651_RS01340	COG3036	rescue of stalled ribosome
HK1651_RS01345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HK1651_RS01350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HK1651_RS01355	COG2841	Protein conserved in bacteria
HK1651_RS01370	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HK1651_RS01380	COG0569	domain protein
HK1651_RS01385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HK1651_RS01385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HK1651_RS01425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HK1651_RS01445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HK1651_RS01450	COG2990	Protein conserved in bacteria
HK1651_RS01460	COG0606	chelatase, subunit chli
HK1651_RS01480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HK1651_RS01570	COG0606	chelatase, subunit chli
HK1651_RS01575	COG2861	carbohydrate metabolic process
HK1651_RS01580	COG4942	peptidase
HK1651_RS01585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HK1651_RS01600	COG2853	Lipoprotein
HK1651_RS01605	COG0747	negative chemotaxis
HK1651_RS01630	COG0814	amino acid
HK1651_RS01640	COG4783	chaperone-mediated protein folding
HK1651_RS01645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HK1651_RS01655	COG0552	protein localization to endoplasmic reticulum
HK1651_RS01660	COG0742	ribosomal rna small subunit methyltransferase
HK1651_RS01665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HK1651_RS01665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HK1651_RS01670	COG3715	PTS system
HK1651_RS01675	COG3716	PTS system mannose fructose sorbose family IID component
HK1651_RS01680	COG0561	phosphatase activity
HK1651_RS01685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HK1651_RS01700	COG0726	polysaccharide deacetylase
HK1651_RS01700	COG1649	PFAM Uncharacterised BCR, COG1649
HK1651_RS01705	COG1215	transferase activity, transferring glycosyl groups
HK1651_RS01715	COG2271	Major facilitator Superfamily
HK1651_RS01745	COG0513	Belongs to the DEAD box helicase family
HK1651_RS01755	COG3201	nicotinamide mononucleotide transporter
HK1651_RS01770	COG1238	metal cluster binding
HK1651_RS01775	COG0110	maltose O-acetyltransferase activity
HK1651_RS01780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HK1651_RS01805	COG0210	DNA helicase
HK1651_RS01810	COG5645	(Lipo)protein
HK1651_RS01820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HK1651_RS01820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HK1651_RS01835	COG0737	Belongs to the 5'-nucleotidase family
HK1651_RS01845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HK1651_RS01855	COG0859	PFAM glycosyl transferase family 9
HK1651_RS01860	COG0754	glutathionylspermidine amidase activity
HK1651_RS01865	COG3005	denitrification pathway
HK1651_RS01870	COG3043	anaerobic respiration
HK1651_RS01875	COG0348	domain, Protein
HK1651_RS01880	COG0437	4 iron, 4 sulfur cluster binding
HK1651_RS01885	COG0243	molybdopterin cofactor binding
HK1651_RS01890	COG3062	negative regulation of establishment of protein localization
HK1651_RS01895	COG3850	Histidine kinase
HK1651_RS01900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HK1651_RS01910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HK1651_RS01915	COG3070	regulator of competence-specific genes
HK1651_RS01920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HK1651_RS01935	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HK1651_RS01945	COG0583	DNA-binding transcription factor activity
HK1651_RS01950	COG2962	Rard protein
HK1651_RS01965	COG0551	DNA topoisomerase type I activity
HK1651_RS01990	COG0705	Rhomboid family
HK1651_RS01995	COG1349	DNA-binding transcription factor activity
HK1651_RS02005	COG4178	(ABC) transporter
HK1651_RS02020	COG0233	cytoplasmic translational termination
HK1651_RS02035	COG0575	Belongs to the CDS family
HK1651_RS02050	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HK1651_RS02070	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HK1651_RS02080	COG0471	metal ion transport
HK1651_RS02080	COG0490	domain, Protein
HK1651_RS02085	COG4589	Belongs to the CDS family
HK1651_RS02090	COG0521	Mo-molybdopterin cofactor biosynthetic process
HK1651_RS02125	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HK1651_RS02125	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HK1651_RS02130	COG0516	GMP reductase activity
HK1651_RS02130	COG0517	IMP dehydrogenase activity
HK1651_RS02140	COG2932	Transcriptional regulator
HK1651_RS02145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HK1651_RS02150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HK1651_RS02160	COG2062	phosphohistidine phosphatase, SixA
HK1651_RS02175	COG3100	YcgL domain-containing protein
HK1651_RS02180	COG0791	NLP P60 protein
HK1651_RS02190	COG2890	protein-(glutamine-N5) methyltransferase activity
HK1651_RS02195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HK1651_RS02200	COG3133	Outer membrane lipoprotein
HK1651_RS02205	COG3102	Protein conserved in bacteria
HK1651_RS02215	COG5339	Protein conserved in bacteria
HK1651_RS02220	COG0443	Heat shock 70 kDa protein
HK1651_RS02225	COG0484	heat shock protein binding
HK1651_RS02240	COG0626	cystathionine gamma-synthase activity
HK1651_RS02245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HK1651_RS02275	COG3021	interspecies interaction between organisms
HK1651_RS02300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HK1651_RS02305	COG2999	glutathione oxidoreductase activity
HK1651_RS02310	COG1530	ribonuclease E activity
HK1651_RS02315	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HK1651_RS02365	COG1840	ABC-type Fe3 transport system, periplasmic component
HK1651_RS02370	COG1840	ABC-type Fe3 transport system, periplasmic component
HK1651_RS02395	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HK1651_RS02400	COG1959	2 iron, 2 sulfur cluster binding
HK1651_RS02410	COG0822	iron-sulfur transferase activity
HK1651_RS02425	COG0443	Heat shock 70 kDa protein
HK1651_RS02430	COG0633	Ferredoxin
HK1651_RS02435	COG2975	iron-sulfur cluster assembly
HK1651_RS02440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK1651_RS02440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HK1651_RS02445	COG0489	protein tyrosine kinase activity
HK1651_RS02455	COG0105	UTP biosynthetic process
HK1651_RS02475	COG4535	Mg2 and Co2 transporter CorC
HK1651_RS02480	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HK1651_RS02490	COG2301	Belongs to the HpcH HpaI aldolase family
HK1651_RS02495	COG3051	citrate lyase alpha subunit
HK1651_RS02500	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HK1651_RS02500	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
HK1651_RS02505	COG0471	metal ion transport
HK1651_RS02520	COG2017	converts alpha-aldose to the beta-anomer
HK1651_RS02525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HK1651_RS02530	COG1085	galactose-1-phosphate uridylyltransferase
HK1651_RS02535	COG1609	Transcriptional regulator
HK1651_RS02540	COG1879	ABC-type sugar transport system periplasmic component
HK1651_RS02550	COG4211	Belongs to the binding-protein-dependent transport system permease family
HK1651_RS02555	COG2198	Histidine kinase
HK1651_RS02555	COG5002	protein histidine kinase activity
HK1651_RS02555	COG0784	Response regulator, receiver
HK1651_RS02560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HK1651_RS02565	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HK1651_RS02565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HK1651_RS02575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HK1651_RS02585	COG0497	DNA recombination
HK1651_RS02590	COG3047	cAMP biosynthetic process
HK1651_RS02605	COG1607	acyl-coa hydrolase
HK1651_RS02610	COG2350	Protein conserved in bacteria
HK1651_RS02615	COG0741	lytic transglycosylase activity
HK1651_RS02625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HK1651_RS02650	COG0582	viral genome integration into host DNA
HK1651_RS02665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HK1651_RS02670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HK1651_RS02680	COG1408	metallophosphoesterase
HK1651_RS02685	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HK1651_RS02690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HK1651_RS02695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HK1651_RS02700	COG1120	ATPase activity
HK1651_RS02710	COG1053	succinate dehydrogenase
HK1651_RS02715	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HK1651_RS02725	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HK1651_RS02760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HK1651_RS02765	COG0494	nUDIX hydrolase
HK1651_RS02770	COG1876	peptidase activity
HK1651_RS02780	COG1393	Belongs to the ArsC family
HK1651_RS02785	COG0326	Molecular chaperone. Has ATPase activity
HK1651_RS02790	COG0077	Prephenate dehydratase
HK1651_RS02790	COG1605	Chorismate mutase
HK1651_RS02800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HK1651_RS02805	COG0849	cell division
HK1651_RS02810	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HK1651_RS02825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HK1651_RS02835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HK1651_RS02845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HK1651_RS02855	COG0768	penicillin binding
HK1651_RS02860	COG3116	cell division
HK1651_RS02875	COG1966	Carbon starvation protein
HK1651_RS02880	COG4160	amino acid transport
HK1651_RS02885	COG4215	(ABC) transporter
HK1651_RS02890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HK1651_RS02895	COG1126	abc transporter atp-binding protein
HK1651_RS02905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HK1651_RS02920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HK1651_RS02945	COG4964	Belongs to the GSP D family
HK1651_RS03005	COG0733	neurotransmitter:sodium symporter activity
HK1651_RS03015	COG1285	pathogenesis
HK1651_RS03030	COG1921	L-seryl-tRNASec selenium transferase activity
HK1651_RS03035	COG0442	prolyl-tRNA aminoacylation
HK1651_RS03040	COG2076	Multidrug Resistance protein
HK1651_RS03050	COG1595	DNA-templated transcription, initiation
HK1651_RS03055	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HK1651_RS03060	COG3026	antisigma factor binding
HK1651_RS03070	COG1763	Mo-molybdopterin cofactor biosynthetic process
HK1651_RS03075	COG0300	oxidoreductase activity
HK1651_RS03080	COG2195	Cleaves the N-terminal amino acid of tripeptides
HK1651_RS03090	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HK1651_RS03095	COG2818	Glycosylase
HK1651_RS03100	COG3477	response to acidic pH
HK1651_RS03105	COG0019	diaminopimelate decarboxylase activity
HK1651_RS03115	COG0514	ATP-dependent DNA helicase (RecQ)
HK1651_RS03120	COG0187	DNA topoisomerase II activity
HK1651_RS03125	COG1072	(Pantothenic acid kinase))
HK1651_RS03150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HK1651_RS03155	COG1879	ABC-type sugar transport system periplasmic component
HK1651_RS03160	COG1129	ABC transporter
HK1651_RS03165	COG1172	Belongs to the binding-protein-dependent transport system permease family
HK1651_RS03175	COG2183	response to ionizing radiation
HK1651_RS03180	COG0583	DNA-binding transcription factor activity
HK1651_RS03185	COG0471	metal ion transport
HK1651_RS03195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HK1651_RS03205	COG1595	DNA-templated transcription, initiation
HK1651_RS03215	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HK1651_RS03220	COG3071	HemY protein
HK1651_RS03225	COG2959	enzyme of heme biosynthesis
HK1651_RS03235	COG0181	hydroxymethylbilane synthase activity
HK1651_RS03245	COG2197	response regulator
HK1651_RS03250	COG0729	surface antigen
HK1651_RS03255	COG2911	Protein conserved in bacteria
HK1651_RS03260	COG0248	Ppx GppA phosphatase
HK1651_RS03280	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HK1651_RS03285	COG3068	Protein conserved in bacteria
HK1651_RS03295	COG1349	DNA-binding transcription factor activity
HK1651_RS03300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HK1651_RS03325	COG2272	Belongs to the type-B carboxylesterase lipase family
HK1651_RS03330	COG0667	Aldo Keto reductase
HK1651_RS03335	COG0656	L-ascorbic acid biosynthetic process
HK1651_RS03350	COG0433	COG0433 Predicted ATPase
HK1651_RS03355	COG2258	MOSC domain
HK1651_RS03360	COG3012	SEC-C Motif Domain Protein
HK1651_RS03375	COG0786	glutamate:sodium symporter activity
HK1651_RS03380	COG2205	protein histidine kinase activity
HK1651_RS03385	COG0745	RESPONSE REGULATOR receiver
HK1651_RS03390	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HK1651_RS03400	COG3082	Protein of unknown function (DUF1414)
HK1651_RS03405	COG3083	sulfuric ester hydrolase activity
HK1651_RS03410	COG0402	S-adenosylhomocysteine deaminase activity
HK1651_RS03415	COG3956	TIGRFAM MazG family protein
HK1651_RS03430	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HK1651_RS03435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HK1651_RS03440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HK1651_RS03445	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HK1651_RS03450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HK1651_RS03465	COG0148	phosphopyruvate hydratase activity
HK1651_RS03475	COG2991	Protein conserved in bacteria
HK1651_RS03480	COG1477	protein flavinylation
HK1651_RS03485	COG2871	sodium ion transport
HK1651_RS03490	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HK1651_RS03495	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HK1651_RS03500	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HK1651_RS03515	COG0271	Belongs to the BolA IbaG family
HK1651_RS03520	COG3056	Lipoprotein
HK1651_RS03545	COG1194	a g-specific adenine glycosylase
HK1651_RS03555	COG3171	Protein conserved in bacteria
HK1651_RS03560	COG1840	ABC-type Fe3 transport system, periplasmic component
HK1651_RS03565	COG1178	ABC-type Fe3 transport system permease component
HK1651_RS03570	COG3842	ATPase activity
HK1651_RS03580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HK1651_RS03590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HK1651_RS03600	COG1561	YicC-like family, N-terminal region
HK1651_RS03605	COG0354	folic acid binding
HK1651_RS03620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HK1651_RS03625	COG1381	Involved in DNA repair and RecF pathway recombination
HK1651_RS03630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HK1651_RS03635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HK1651_RS03640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HK1651_RS03660	COG0789	Transcriptional regulator
HK1651_RS03665	COG4701	Protein of unknown function (DUF721)
HK1651_RS03680	COG0494	nUDIX hydrolase
HK1651_RS03685	COG1466	dna polymerase III delta subunit
HK1651_RS03690	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HK1651_RS03705	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HK1651_RS03710	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
HK1651_RS03715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HK1651_RS03720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HK1651_RS03725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HK1651_RS03745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HK1651_RS03750	COG4221	oxidoreductase activity
HK1651_RS03760	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HK1651_RS03765	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HK1651_RS03770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HK1651_RS03775	COG4137	Cytochrome C assembly protein
HK1651_RS03780	COG4536	flavin adenine dinucleotide binding
HK1651_RS03785	COG0811	peptide transport
HK1651_RS03790	COG0848	biopolymer transport protein
HK1651_RS03840	COG0243	molybdopterin cofactor binding
HK1651_RS03845	COG0437	4 iron, 4 sulfur cluster binding
HK1651_RS03855	COG3381	protein complex oligomerization
HK1651_RS03860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HK1651_RS03860	COG2221	Nitrite and sulphite reductase 4Fe-4S
HK1651_RS03870	COG4545	Glutaredoxin-related protein
HK1651_RS03895	COG0805	protein transport
HK1651_RS03900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HK1651_RS03905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HK1651_RS03910	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HK1651_RS03915	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HK1651_RS03920	COG1011	Hydrolase
HK1651_RS03925	COG0494	nUDIX hydrolase
HK1651_RS03930	COG1917	Cupin 2, conserved barrel domain protein
HK1651_RS03930	COG4977	sequence-specific DNA binding
HK1651_RS03935	COG3059	membrane
HK1651_RS03940	COG1297	OPT oligopeptide transporter protein
HK1651_RS03950	COG1218	3'(2'),5'-bisphosphate nucleotidase
HK1651_RS03955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HK1651_RS03960	COG0363	glucosamine-6-phosphate deaminase activity
HK1651_RS03970	COG1794	racemase activity, acting on amino acids and derivatives
HK1651_RS03975	COG4545	Glutaredoxin-related protein
HK1651_RS03990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HK1651_RS03995	COG1028	Short-chain dehydrogenase reductase Sdr
HK1651_RS04005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HK1651_RS04060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HK1651_RS04085	COG1011	Hydrolase
HK1651_RS04095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HK1651_RS04100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HK1651_RS04120	COG1596	polysaccharide export
HK1651_RS04120	COG1555	photosystem II stabilization
HK1651_RS04125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HK1651_RS04130	COG0561	phosphatase activity
HK1651_RS04135	COG1040	competence protein
HK1651_RS04145	COG1114	Component of the transport system for branched-chain amino acids
HK1651_RS04170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HK1651_RS04180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HK1651_RS04190	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HK1651_RS04210	COG0201	protein transport
HK1651_RS04225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HK1651_RS04245	COG0814	amino acid
HK1651_RS04250	COG2129	metallophosphoesterase
HK1651_RS04255	COG3172	ATPase kinase involved in NAD metabolism
HK1651_RS04265	COG1739	Uncharacterized protein family UPF0029
HK1651_RS04275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HK1651_RS04280	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HK1651_RS04315	COG2801	Transposase and inactivated derivatives
HK1651_RS04325	COG0859	PFAM glycosyl transferase family 9
HK1651_RS04330	COG1027	Aspartate ammonia-lyase
HK1651_RS04340	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HK1651_RS04345	COG0459	protein refolding
HK1651_RS04380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HK1651_RS04390	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HK1651_RS04405	COG4796	Type ii and iii secretion system protein
HK1651_RS04425	COG4972	Pilus assembly protein
HK1651_RS04430	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HK1651_RS04435	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HK1651_RS04440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HK1651_RS04455	COG1309	transcriptional regulator
HK1651_RS04465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HK1651_RS04480	COG2932	Transcriptional regulator
HK1651_RS04515	COG3306	glycosyltransferase involved in LPS biosynthesis
HK1651_RS04525	COG3306	glycosyltransferase involved in LPS biosynthesis
HK1651_RS04540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HK1651_RS04545	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HK1651_RS04550	COG1309	transcriptional regulator
HK1651_RS04555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK1651_RS04560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HK1651_RS04565	COG0500	methyltransferase
HK1651_RS04575	COG0762	integral membrane protein
HK1651_RS04585	COG0778	Nitroreductase
HK1651_RS04590	COG1368	sulfuric ester hydrolase activity
HK1651_RS04595	COG1496	oxidoreductase activity
HK1651_RS04610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HK1651_RS04625	COG0006	proline dipeptidase activity
HK1651_RS04650	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HK1651_RS04655	COG1792	Involved in formation and maintenance of cell shape
HK1651_RS04660	COG1077	Cell shape determining protein MreB Mrl
HK1651_RS04665	COG0557	exoribonuclease II activity
HK1651_RS04675	COG2271	Major facilitator Superfamily
HK1651_RS04680	COG0584	glycerophosphoryl diester phosphodiesterase
HK1651_RS04685	COG0758	DNA mediated transformation
HK1651_RS04720	COG1132	(ABC) transporter
HK1651_RS04725	COG4977	sequence-specific DNA binding
HK1651_RS04725	COG1917	Cupin 2, conserved barrel domain protein
HK1651_RS04730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HK1651_RS04735	COG0859	PFAM glycosyl transferase family 9
HK1651_RS04750	COG1519	Transferase
HK1651_RS04755	COG0463	Glycosyl transferase, family 2
HK1651_RS04765	COG4942	peptidase
HK1651_RS04765	COG1388	LysM domain
HK1651_RS04775	COG1238	metal cluster binding
HK1651_RS04785	COG0585	pseudouridine synthase activity
HK1651_RS04805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HK1651_RS04815	COG2884	Cell division ATP-binding protein ftsE
HK1651_RS04820	COG2177	Part of the ABC transporter FtsEX involved in
HK1651_RS04825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HK1651_RS04830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HK1651_RS04840	COG0561	phosphatase activity
HK1651_RS04845	COG2267	carboxylic ester hydrolase activity
HK1651_RS04850	COG3307	-O-antigen
HK1651_RS04855	COG0191	fructose-bisphosphate aldolase activity
HK1651_RS04865	COG3719	Belongs to the RNase T2 family
HK1651_RS04870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HK1651_RS04875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HK1651_RS04880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HK1651_RS04885	COG2801	Transposase and inactivated derivatives
HK1651_RS04895	COG0582	viral genome integration into host DNA
HK1651_RS04900	COG1070	Carbohydrate kinase
HK1651_RS04905	COG2115	Belongs to the xylose isomerase family
HK1651_RS04910	COG4213	ABC transporter substrate-binding protein
HK1651_RS04915	COG1129	ABC transporter
HK1651_RS04920	COG4214	carbohydrate transport
HK1651_RS04925	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HK1651_RS04930	COG1757	Na H antiporter
HK1651_RS04935	COG1609	Transcriptional regulator
HK1651_RS04935	COG2207	Transcriptional regulator
HK1651_RS04940	COG2814	Major facilitator Superfamily
HK1651_RS04945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HK1651_RS04945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HK1651_RS04950	COG3715	PTS system
HK1651_RS04955	COG3716	PTS system mannose fructose sorbose family IID component
HK1651_RS04985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HK1651_RS05000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HK1651_RS05010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HK1651_RS05030	COG3312	ion transport
HK1651_RS05040	COG1733	regulation of RNA biosynthetic process
HK1651_RS05045	COG0702	epimerase
HK1651_RS05055	COG0716	FMN binding
HK1651_RS05065	COG1494	fructose-1,6-bisphosphatase
HK1651_RS05070	COG1045	serine acetyltransferase
HK1651_RS05080	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HK1651_RS05085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HK1651_RS05090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HK1651_RS05095	COG4988	ABC transporter
HK1651_RS05100	COG1132	(ABC) transporter
HK1651_RS05105	COG1309	transcriptional regulator
HK1651_RS05110	COG0583	DNA-binding transcription factor activity
HK1651_RS05115	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HK1651_RS05115	COG0678	peroxiredoxin activity
HK1651_RS05120	COG2900	Belongs to the SlyX family
HK1651_RS05125	COG0545	Peptidyl-prolyl cis-trans isomerase
HK1651_RS05130	COG2964	Protein conserved in bacteria
HK1651_RS05135	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HK1651_RS05145	COG2168	tRNA wobble position uridine thiolation
HK1651_RS05150	COG1126	abc transporter atp-binding protein
HK1651_RS05155	COG0765	amino acid transport
HK1651_RS05160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HK1651_RS05165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HK1651_RS05190	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HK1651_RS05200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HK1651_RS05210	COG1349	DNA-binding transcription factor activity
HK1651_RS05220	COG2963	transposase activity
HK1651_RS05240	COG2095	MarC family integral membrane protein
HK1651_RS05245	COG0488	(ABC) transporter
HK1651_RS05250	COG0488	(ABC) transporter
HK1651_RS05255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HK1651_RS05260	COG2137	regulation of response to DNA damage stimulus
HK1651_RS05265	COG0251	oxidation-reduction process
HK1651_RS05275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HK1651_RS05300	COG4172	Belongs to the ABC transporter superfamily
HK1651_RS05305	COG4172	Belongs to the ABC transporter superfamily
HK1651_RS05310	COG4171	peptide transport system, permease
HK1651_RS05315	COG4168	peptide transport system, permease
HK1651_RS05320	COG4166	transmembrane transport
HK1651_RS05325	COG3106	COG3106 Predicted ATPase
HK1651_RS05335	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HK1651_RS05340	COG1923	regulation of RNA biosynthetic process
HK1651_RS05350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HK1651_RS05355	COG0860	N-Acetylmuramoyl-L-alanine amidase
HK1651_RS05355	COG1388	LysM domain
HK1651_RS05360	COG0802	atpase or kinase
HK1651_RS05375	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HK1651_RS05385	COG2194	sulfuric ester hydrolase activity
HK1651_RS05405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HK1651_RS05410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HK1651_RS05415	COG2190	(PTS) system
HK1651_RS05420	COG0339	signal peptide processing
HK1651_RS05425	COG2832	Protein of unknown function (DUF454)
HK1651_RS05430	COG4166	transmembrane transport
HK1651_RS05435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HK1651_RS05445	COG0512	Glutamine amidotransferase of anthranilate synthase
HK1651_RS05450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HK1651_RS05455	COG4591	ABC-type transport system involved in lipoprotein release permease component
HK1651_RS05465	COG4591	ABC-type transport system involved in lipoprotein release permease component
HK1651_RS05470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HK1651_RS05475	COG0305	Participates in initiation and elongation during chromosome replication
HK1651_RS05485	COG0166	Belongs to the GPI family
HK1651_RS05490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HK1651_RS05500	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HK1651_RS05505	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HK1651_RS05510	COG1280	lysine exporter protein (LysE YggA)
HK1651_RS05520	COG0633	Ferredoxin
HK1651_RS05530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HK1651_RS05540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HK1651_RS05550	COG1840	ABC-type Fe3 transport system, periplasmic component
HK1651_RS05560	COG3842	ATPase activity
HK1651_RS05565	COG0366	Alpha amylase catalytic
HK1651_RS05570	COG3833	ABC-type maltose transport systems, permease component
HK1651_RS05580	COG2182	Extracellular solute-binding protein
HK1651_RS05585	COG3842	ATPase activity
HK1651_RS05590	COG4580	involved in the transport of maltose and maltodextrins
HK1651_RS05600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HK1651_RS05605	COG0303	'Molybdopterin
HK1651_RS05615	COG2027	D-alanyl-D-alanine carboxypeptidase
HK1651_RS05620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HK1651_RS05625	COG1534	Rna-binding protein
HK1651_RS05630	COG3657	addiction module killer protein
HK1651_RS05635	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HK1651_RS05640	COG0307	riboflavin synthase, alpha
HK1651_RS05650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HK1651_RS05655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HK1651_RS05660	COG0725	ABC transporter, periplasmic molybdate-binding protein
HK1651_RS05665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HK1651_RS05670	COG3842	ATPase activity
HK1651_RS05675	COG0157	Belongs to the NadC ModD family
HK1651_RS05690	COG2855	membrane
HK1651_RS05695	COG4953	penicillin-binding protein 1C
HK1651_RS05700	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HK1651_RS05725	COG3623	hexulose-6-phosphate isomerase
HK1651_RS05730	COG0235	Class ii aldolase
HK1651_RS05735	COG0814	amino acid
HK1651_RS05745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HK1651_RS05750	COG0778	Nitroreductase
HK1651_RS05760	COG2268	Band 7 protein
HK1651_RS05765	COG0114	fumarate hydratase activity
HK1651_RS05770	COG2927	DNA polymerase III (CHI subunit)
HK1651_RS05800	COG3550	peptidyl-serine autophosphorylation
HK1651_RS05810	COG2814	Major facilitator Superfamily
HK1651_RS05815	COG1566	PFAM secretion protein HlyD family protein
HK1651_RS05820	COG0783	Belongs to the Dps family
HK1651_RS05830	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HK1651_RS05835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HK1651_RS05840	COG0602	queuosine metabolic process
HK1651_RS05845	COG0720	synthase
HK1651_RS05850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HK1651_RS05860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HK1651_RS05865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HK1651_RS05870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HK1651_RS05875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HK1651_RS05880	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
HK1651_RS05885	COG0310	cobalt ion transport
HK1651_RS05890	COG0310	cobalt ion transport
HK1651_RS05895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HK1651_RS05900	COG1122	ATPase activity
HK1651_RS05905	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HK1651_RS05910	COG0409	Hydrogenase expression formation protein
HK1651_RS05915	COG0309	Hydrogenase expression formation protein (HypE)
HK1651_RS05930	COG2801	Transposase and inactivated derivatives
HK1651_RS05950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HK1651_RS05955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HK1651_RS05960	COG0795	lipopolysaccharide-transporting ATPase activity
HK1651_RS05965	COG0795	lipopolysaccharide-transporting ATPase activity
HK1651_RS05970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HK1651_RS05975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HK1651_RS05980	COG4149	molybdate abc transporter
HK1651_RS05985	COG0725	ABC transporter, periplasmic molybdate-binding protein
HK1651_RS05990	COG2005	Transcriptional regulator
HK1651_RS05995	COG0471	metal ion transport
HK1651_RS06005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HK1651_RS06010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HK1651_RS06010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HK1651_RS06015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HK1651_RS06025	COG0583	DNA-binding transcription factor activity
HK1651_RS06030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HK1651_RS06040	COG0039	L-malate dehydrogenase activity
HK1651_RS06045	COG1438	arginine binding
HK1651_RS06050	COG1090	epimerase
HK1651_RS06055	COG4657	Part of a membrane complex involved in electron transport
HK1651_RS06085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HK1651_RS06090	COG0733	neurotransmitter:sodium symporter activity
HK1651_RS06095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HK1651_RS06105	COG0739	heme binding
HK1651_RS06110	COG4604	ABC transporter, ATP-binding protein
HK1651_RS06115	COG4605	iron ion homeostasis
HK1651_RS06120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HK1651_RS06125	COG4607	ABC-type enterochelin transport system periplasmic component
HK1651_RS06130	COG0737	Belongs to the 5'-nucleotidase family
HK1651_RS06140	COG3111	PFAM Bacterial OB fold (BOF) protein
HK1651_RS06145	COG0745	RESPONSE REGULATOR receiver
HK1651_RS06175	COG0642	Histidine kinase
HK1651_RS06180	COG0405	Gamma-glutamyltransferase
HK1651_RS06195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HK1651_RS06200	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HK1651_RS06205	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HK1651_RS06235	COG4143	(ABC) transporter
HK1651_RS06240	COG1178	ABC-type Fe3 transport system permease component
HK1651_RS06245	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HK1651_RS06255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HK1651_RS06260	COG3105	Protein conserved in bacteria
HK1651_RS06265	COG1944	ATP diphosphatase activity
HK1651_RS06275	COG3422	double-strand break repair
HK1651_RS06290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HK1651_RS06300	COG1940	carbohydrate kinase activity
HK1651_RS06300	COG1846	Transcriptional regulator
HK1651_RS06325	COG0563	adenylate kinase activity
HK1651_RS06330	COG2814	Major facilitator Superfamily
HK1651_RS06335	COG0375	protein maturation
HK1651_RS06340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HK1651_RS06345	COG3152	Membrane
HK1651_RS06350	COG2252	PERMEase
HK1651_RS06365	COG0825	malonyl-CoA metabolic process
HK1651_RS06370	COG2351	hydroxyisourate hydrolase activity
HK1651_RS06425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HK1651_RS06445	COG3041	Addiction module toxin RelE StbE family
HK1651_RS06450	COG3077	Addiction module antitoxin, RelB DinJ family
HK1651_RS06455	COG3069	C4-dicarboxylate transmembrane transporter activity
HK1651_RS06470	COG0195	Participates in both transcription termination and antitermination
HK1651_RS06490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HK1651_RS06495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HK1651_RS06520	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HK1651_RS06525	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HK1651_RS06530	COG3177	Filamentation induced by cAMP protein fic
HK1651_RS06540	COG3842	ATPase activity
HK1651_RS06545	COG1175	transmembrane transport
HK1651_RS06550	COG0395	ABC-type sugar transport system, permease component
HK1651_RS06560	COG0322	excinuclease ABC activity
HK1651_RS06570	COG2835	tetraacyldisaccharide 4'-kinase activity
HK1651_RS06575	COG1663	tetraacyldisaccharide 4'-kinase activity
HK1651_RS06580	COG1132	(ABC) transporter
HK1651_RS06585	COG0658	competence protein
HK1651_RS06585	COG2333	competence protein COMEC
HK1651_RS06590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HK1651_RS06595	COG0617	tRNA 3'-terminal CCA addition
HK1651_RS06600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HK1651_RS06610	COG0280	phosphate acetyltransferase
HK1651_RS06610	COG0857	belongs to the CobB CobQ family
HK1651_RS06615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HK1651_RS06620	COG3092	negative regulation of chromosome organization
HK1651_RS06625	COG1286	toxin biosynthetic process
HK1651_RS06630	COG1640	4-alpha-glucanotransferase
HK1651_RS06635	COG0058	SHG alpha-glucan phosphorylase activity
HK1651_RS06640	COG2909	trisaccharide binding
HK1651_RS06650	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HK1651_RS06655	COG0508	dehydrogenase complex catalyzes the overall conversion of
HK1651_RS06660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HK1651_RS06665	COG0778	Nitroreductase
HK1651_RS06670	COG0616	signal peptide processing
HK1651_RS06675	COG1605	Chorismate mutase
HK1651_RS06675	COG0287	Prephenate dehydrogenase
HK1651_RS06680	COG1605	Chorismate mutase
HK1651_RS06680	COG0287	Prephenate dehydrogenase
HK1651_RS06685	COG0009	L-threonylcarbamoyladenylate synthase
HK1651_RS06695	COG0583	DNA-binding transcription factor activity
HK1651_RS06705	COG3099	Belongs to the UPF0263 family
HK1651_RS06715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HK1651_RS06720	COG2949	membrane
HK1651_RS06740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HK1651_RS06745	COG0785	Cytochrome C biogenesis protein
HK1651_RS06750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HK1651_RS06750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HK1651_RS06755	COG0288	reversible hydration of carbon dioxide
HK1651_RS06760	COG2823	Periplasmic or secreted lipoprotein
HK1651_RS06765	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HK1651_RS06770	COG0792	nuclease activity
HK1651_RS06780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HK1651_RS06790	COG1252	NADH dehydrogenase
HK1651_RS06800	COG0616	signal peptide processing
HK1651_RS06805	COG3047	cAMP biosynthetic process
HK1651_RS06805	COG2885	chlorophyll binding
HK1651_RS06830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HK1651_RS06835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HK1651_RS06840	COG3684	Belongs to the aldolase LacD family
HK1651_RS06850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HK1651_RS06855	COG3414	Phosphotransferase system galactitol-specific IIB component
HK1651_RS06860	COG3775	system Galactitol-specific IIC component
HK1651_RS06865	COG1063	alcohol dehydrogenase
HK1651_RS06870	COG1349	DNA-binding transcription factor activity
HK1651_RS06880	COG0142	geranyltranstransferase activity
HK1651_RS06895	COG0285	dihydrofolate synthase activity
HK1651_RS06900	COG0406	alpha-ribazole phosphatase activity
HK1651_RS06905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HK1651_RS06910	COG2431	L-lysine efflux transmembrane transporter activity
HK1651_RS06915	COG0564	pseudouridine synthase activity
HK1651_RS06925	COG2824	Alkylphosphonate utilization operon protein PhnA
HK1651_RS06955	COG1538	Outer membrane efflux protein
HK1651_RS06960	COG0577	efflux transmembrane transporter activity
HK1651_RS06960	COG1136	(ABC) transporter
HK1651_RS06965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK1651_RS06990	COG1523	belongs to the glycosyl hydrolase 13 family
HK1651_RS07005	COG0058	SHG alpha-glucan phosphorylase activity
HK1651_RS07010	COG0586	Pfam SNARE associated Golgi protein
HK1651_RS07015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HK1651_RS07025	COG1686	Belongs to the peptidase S11 family
HK1651_RS07030	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HK1651_RS07035	COG0204	Acyl-transferase
HK1651_RS07035	COG0318	PFAM AMP-dependent synthetase and ligase
HK1651_RS07040	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HK1651_RS07045	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HK1651_RS07050	COG0697	spore germination
HK1651_RS07055	COG2925	Exonuclease
HK1651_RS07080	COG1528	Iron-storage protein
HK1651_RS07085	COG1528	Iron-storage protein
HK1651_RS07090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HK1651_RS07095	COG0589	response to stress
HK1651_RS07100	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
HK1651_RS07110	COG0613	PHP domain protein
HK1651_RS07115	COG0167	dihydroorotate dehydrogenase activity
HK1651_RS07120	COG0308	aminopeptidase N
HK1651_RS07125	COG1448	Aminotransferase
HK1651_RS07135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK1651_RS07140	COG0842	Transport permease protein
HK1651_RS07140	COG1129	ABC transporter
HK1651_RS07145	COG0842	Transport permease protein
HK1651_RS07155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HK1651_RS07160	COG1120	ATPase activity
HK1651_RS07180	COG1120	ATPase activity
HK1651_RS07185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HK1651_RS07190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HK1651_RS07200	COG4774	siderophore transport
HK1651_RS07215	COG0791	NLP P60 protein
HK1651_RS07230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HK1651_RS07240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HK1651_RS07240	COG0517	IMP dehydrogenase activity
HK1651_RS07245	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HK1651_RS07250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HK1651_RS07255	COG0512	Glutamine amidotransferase of anthranilate synthase
HK1651_RS07260	COG1942	4-Oxalocrotonate Tautomerase
HK1651_RS07265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HK1651_RS07275	COG3093	addiction module antidote protein HigA
HK1651_RS07280	COG0134	indole-3-glycerol-phosphate synthase activity
HK1651_RS07280	COG0135	phosphoribosylanthranilate isomerase activity
HK1651_RS07285	COG0298	carbon dioxide binding
HK1651_RS07295	COG3630	sodium ion export across plasma membrane
HK1651_RS07310	COG1629	transport
HK1651_RS07310	COG4771	TonB-dependent receptor
HK1651_RS07315	COG1629	transport
HK1651_RS07315	COG4771	TonB-dependent receptor
HK1651_RS07325	COG4221	oxidoreductase activity
HK1651_RS07330	COG0133	tryptophan synthase activity
HK1651_RS07340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HK1651_RS07350	COG0469	pyruvate kinase activity
HK1651_RS07365	COG1879	ABC-type sugar transport system periplasmic component
HK1651_RS07375	COG1172	Belongs to the binding-protein-dependent transport system permease family
HK1651_RS07390	COG2390	Transcriptional regulator
HK1651_RS07395	COG1070	Carbohydrate kinase
HK1651_RS07400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HK1651_RS07405	COG1940	carbohydrate kinase activity
HK1651_RS07415	COG2969	positive regulation of protein catabolic process
HK1651_RS07425	COG0314	molybdopterin synthase activity
HK1651_RS07430	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HK1651_RS07440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HK1651_RS07465	COG3005	denitrification pathway
HK1651_RS07470	COG0243	molybdopterin cofactor binding
HK1651_RS07475	COG2315	Protein conserved in bacteria
HK1651_RS07480	COG0471	metal ion transport
HK1651_RS07495	COG0101	tRNA pseudouridine synthase activity
HK1651_RS07515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HK1651_RS07520	COG1074	ATP-dependent DNA helicase activity
HK1651_RS07525	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HK1651_RS07535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HK1651_RS07540	COG1067	ATP-dependent peptidase activity
HK1651_RS07550	COG1278	Cold shock
HK1651_RS07555	COG3140	Belongs to the UPF0181 family
HK1651_RS07565	COG3098	single-species biofilm formation
HK1651_RS07570	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HK1651_RS07575	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HK1651_RS07575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HK1651_RS07605	COG3101	peptidyl-lysine hydroxylation
HK1651_RS07610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HK1651_RS07620	COG0788	formyltetrahydrofolate deformylase activity
HK1651_RS07625	COG2916	Histone family protein nucleoid-structuring protein H-NS
HK1651_RS07630	COG1757	Na H antiporter
HK1651_RS07665	COG3161	chorismate lyase activity
HK1651_RS07675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HK1651_RS07680	COG1758	RNA polymerase activity
HK1651_RS07690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HK1651_RS07700	COG2867	negative regulation of translational initiation
HK1651_RS07710	COG2850	peptidyl-arginine hydroxylation
HK1651_RS07725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HK1651_RS07730	COG1137	ATPase activity
HK1651_RS07735	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HK1651_RS07740	COG3117	lipopolysaccharide transmembrane transporter activity
HK1651_RS07745	COG1127	ABC transporter
HK1651_RS07750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HK1651_RS07755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HK1651_RS07760	COG2854	intermembrane phospholipid transfer
HK1651_RS07765	COG3113	response to antibiotic
HK1651_RS07770	COG5007	Belongs to the BolA IbaG family
HK1651_RS07790	COG0463	Glycosyl transferase, family 2
HK1651_RS07800	COG3691	Protein conserved in bacteria
HK1651_RS07810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HK1651_RS07820	COG0861	Integral membrane protein TerC family
HK1651_RS07845	COG1217	gtp-binding protein TYPA
HK1651_RS07860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HK1651_RS07865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HK1651_RS07880	COG0517	IMP dehydrogenase activity
HK1651_RS07880	COG1125	glycine betaine transport
HK1651_RS07885	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HK1651_RS07895	COG0460	homoserine dehydrogenase
HK1651_RS07895	COG0527	aspartate kinase activity
HK1651_RS07910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HK1651_RS07915	COG2091	lysine biosynthetic process via aminoadipic acid
HK1651_RS07920	COG0330	HflC and HflK could
HK1651_RS07925	COG0330	HflC and HflK could
HK1651_RS07930	COG1555	photosystem II stabilization
HK1651_RS07935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HK1651_RS07945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HK1651_RS07950	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HK1651_RS07955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HK1651_RS07960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HK1651_RS07965	COG0800	Aldolase
HK1651_RS07975	COG1028	Short-chain dehydrogenase reductase Sdr
HK1651_RS07980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HK1651_RS07990	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HK1651_RS08005	COG2186	Transcriptional regulator
HK1651_RS08025	COG0659	secondary active sulfate transmembrane transporter activity
HK1651_RS08035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HK1651_RS08050	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HK1651_RS08055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HK1651_RS08075	COG3115	cell septum assembly
HK1651_RS08085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HK1651_RS08090	COG1573	uracil-dna glycosylase
HK1651_RS08095	COG0012	GTP binding
HK1651_RS08100	COG0193	aminoacyl-tRNA hydrolase activity
HK1651_RS08105	COG2801	Transposase and inactivated derivatives
HK1651_RS08165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HK1651_RS08170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HK1651_RS08180	COG0024	Methionine aminopeptidase
HK1651_RS08185	COG0316	Belongs to the HesB IscA family
HK1651_RS08195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HK1651_RS08200	COG0672	)-iron permease
HK1651_RS08215	COG0577	efflux transmembrane transporter activity
HK1651_RS08225	COG1136	(ABC) transporter
HK1651_RS08225	COG0577	efflux transmembrane transporter activity
HK1651_RS08230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HK1651_RS08240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HK1651_RS08245	COG3385	transposase activity
HK1651_RS08260	COG1643	Atp-dependent helicase
HK1651_RS08265	COG2363	Small membrane protein
HK1651_RS08285	COG0277	FAD linked oxidase domain protein
HK1651_RS08285	COG0247	lactate metabolic process
HK1651_RS08300	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HK1651_RS08305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HK1651_RS08310	COG0363	glucosamine-6-phosphate deaminase activity
HK1651_RS08315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HK1651_RS08320	COG1737	Transcriptional regulator
HK1651_RS08330	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HK1651_RS08335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HK1651_RS08345	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HK1651_RS08350	COG2190	(PTS) system
HK1651_RS08350	COG1263	PTS System
HK1651_RS08350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HK1651_RS08370	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HK1651_RS08375	COG3683	transport system, periplasmic component
HK1651_RS08380	COG0488	(ABC) transporter
HK1651_RS08390	COG0187	DNA topoisomerase II activity
HK1651_RS08395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HK1651_RS08400	COG0625	glutathione transferase activity
HK1651_RS08405	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HK1651_RS08415	COG0251	oxidation-reduction process
HK1651_RS08430	COG0463	Glycosyl transferase, family 2
HK1651_RS08440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HK1651_RS08450	COG1560	Kdo2-lipid A biosynthetic process
HK1651_RS08455	COG0730	response to heat
HK1651_RS08460	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HK1651_RS08465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HK1651_RS08470	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HK1651_RS08470	COG3264	Mechanosensitive ion channel
HK1651_RS08475	COG0318	PFAM AMP-dependent synthetase and ligase
HK1651_RS08480	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HK1651_RS08485	COG0596	Alpha beta hydrolase
HK1651_RS08490	COG0716	FMN binding
HK1651_RS08495	COG0735	belongs to the Fur family
HK1651_RS08500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HK1651_RS08505	COG3094	Invasion gene expression up-regulator, SirB
HK1651_RS08510	COG0023	Translation Initiation Factor
HK1651_RS08520	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HK1651_RS08525	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HK1651_RS08530	COG0776	regulation of translation
HK1651_RS08535	COG0539	negative regulation of cytoplasmic translation
HK1651_RS08545	COG2990	Protein conserved in bacteria
HK1651_RS08550	COG4771	TonB-dependent receptor
HK1651_RS08555	COG4771	TonB-dependent receptor
HK1651_RS08560	COG0612	Peptidase, M16
HK1651_RS08565	COG1687	branched-chain amino acid
HK1651_RS08570	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HK1651_RS08575	COG0583	DNA-binding transcription factor activity
HK1651_RS08590	COG4804	nuclease activity
HK1651_RS08595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HK1651_RS08610	COG2920	part of a sulfur-relay system
HK1651_RS08620	COG1121	(ABC) transporter
HK1651_RS08625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HK1651_RS08630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HK1651_RS08650	COG3304	Inner membrane component domain
HK1651_RS08655	COG1289	transmembrane transporter activity
HK1651_RS08670	COG3958	Transketolase
HK1651_RS08675	COG3959	Transketolase, thiamine diphosphate binding domain
HK1651_RS08700	COG0488	(ABC) transporter
HK1651_RS08710	COG1346	cytolysis
HK1651_RS08725	COG1525	nuclease
HK1651_RS08730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HK1651_RS08735	COG2166	iron-sulfur cluster assembly
HK1651_RS08740	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HK1651_RS08740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HK1651_RS08745	COG1560	Kdo2-lipid A biosynthetic process
HK1651_RS08750	COG3381	protein complex oligomerization
HK1651_RS08755	COG2249	NAD(P)H dehydrogenase (quinone) activity
HK1651_RS08765	COG0330	HflC and HflK could
HK1651_RS08790	COG1858	cytochrome C peroxidase
HK1651_RS08795	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HK1651_RS08800	COG0318	PFAM AMP-dependent synthetase and ligase
HK1651_RS08805	COG3065	identical protein binding
HK1651_RS08810	COG1214	PFAM Peptidase M22, glycoprotease
HK1651_RS08815	COG1199	ATP-dependent helicase activity
HK1651_RS08820	COG0676	glucose-6-phosphate 1-epimerase activity
HK1651_RS08825	COG3118	belongs to the thioredoxin family
HK1651_RS08830	COG0492	ferredoxin-NADP+ reductase activity
HK1651_RS08835	COG4988	ABC transporter
HK1651_RS08840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HK1651_RS08845	COG1946	Acyl-CoA thioesterase
HK1651_RS08850	COG0515	serine threonine protein kinase
HK1651_RS08865	COG1940	carbohydrate kinase activity
HK1651_RS08870	COG0671	phosphoesterase, PA-phosphatase related
HK1651_RS08890	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HK1651_RS08895	COG0708	Exodeoxyribonuclease III
HK1651_RS08920	COG1216	Glycosyl transferase, family 2
HK1651_RS08925	COG2246	polysaccharide biosynthetic process
HK1651_RS08945	COG0463	Glycosyl transferase, family 2
HK1651_RS08980	COG2951	lytic endotransglycosylase activity
HK1651_RS08985	COG1216	Glycosyl transferase, family 2
HK1651_RS08990	COG1216	Glycosyl transferase, family 2
HK1651_RS09000	COG3306	glycosyltransferase involved in LPS biosynthesis
HK1651_RS09010	COG5039	Polysaccharide pyruvyl transferase
HK1651_RS09015	COG2161	toxin-antitoxin pair type II binding
HK1651_RS09020	COG4115	mRNA cleavage
HK1651_RS09025	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HK1651_RS09030	COG1793	dna ligase
HK1651_RS09035	COG0210	DNA helicase
HK1651_RS09040	COG2610	gluconate transmembrane transporter activity
HK1651_RS09045	COG3265	gluconokinase activity
HK1651_RS09050	COG1609	Transcriptional regulator
HK1651_RS09070	COG0437	4 iron, 4 sulfur cluster binding
HK1651_RS09075	COG2864	formate dehydrogenase
HK1651_RS09080	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HK1651_RS09085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HK1651_RS09090	COG0651	ATP synthesis coupled electron transport
HK1651_RS09095	COG0650	Formate hydrogenlyase subunit 4
HK1651_RS09100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HK1651_RS09105	COG4237	Hydrogenase 4 membrane
HK1651_RS09110	COG0651	ATP synthesis coupled electron transport
HK1651_RS09115	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HK1651_RS09115	COG3261	NADH dehydrogenase
HK1651_RS09120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HK1651_RS09125	COG3260	NADH ubiquinone oxidoreductase 20
HK1651_RS09135	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HK1651_RS09140	COG3383	formate dehydrogenase (NAD+) activity
HK1651_RS09145	COG3383	formate dehydrogenase (NAD+) activity
HK1651_RS09150	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HK1651_RS09160	COG0508	dehydrogenase complex catalyzes the overall conversion of
HK1651_RS09165	COG0567	Dehydrogenase, E1 component
HK1651_RS09170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HK1651_RS09175	COG3108	Peptidase M15
HK1651_RS09180	COG2989	Protein conserved in bacteria
HK1651_RS09185	COG0793	Belongs to the peptidase S41A family
HK1651_RS09195	COG2995	paraquat-inducible protein a
HK1651_RS09200	COG3008	intermembrane lipid transfer
HK1651_RS09210	COG3842	ATPase activity
HK1651_RS09215	COG1176	ABC-type spermidine putrescine transport system, permease component I
HK1651_RS09220	COG1177	transmembrane transport
HK1651_RS09225	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HK1651_RS09240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HK1651_RS09245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HK1651_RS09260	COG1522	sequence-specific DNA binding
HK1651_RS09265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HK1651_RS09270	COG3025	triphosphatase activity
HK1651_RS09275	COG1392	Phosphate transport regulator
HK1651_RS09280	COG0306	phosphate transporter
HK1651_RS09285	COG4991	sh3 domain protein
HK1651_RS09290	COG0617	tRNA 3'-terminal CCA addition
HK1651_RS09295	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HK1651_RS09300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HK1651_RS09315	COG1620	l-lactate permease
HK1651_RS09335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HK1651_RS09340	COG0328	RNA-DNA hybrid ribonuclease activity
HK1651_RS09345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HK1651_RS09365	COG2026	Addiction module toxin, RelE StbE family
HK1651_RS09380	COG0826	peptidase U32
HK1651_RS09390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HK1651_RS09400	COG1862	Preprotein translocase
HK1651_RS09405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HK1651_RS09410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HK1651_RS09420	COG1012	belongs to the aldehyde dehydrogenase family
HK1651_RS09420	COG1454	alcohol dehydrogenase
HK1651_RS09425	COG1172	Belongs to the binding-protein-dependent transport system permease family
HK1651_RS09430	COG1129	ABC transporter
HK1651_RS09440	COG1879	ABC-type sugar transport system periplasmic component
HK1651_RS09445	COG0673	inositol 2-dehydrogenase activity
HK1651_RS09455	COG2271	Major facilitator Superfamily
HK1651_RS09465	COG3718	enzyme involved in inositol metabolism
HK1651_RS09475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HK1651_RS09480	COG3962	Belongs to the TPP enzyme family
HK1651_RS09490	COG0673	inositol 2-dehydrogenase activity
HK1651_RS09495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HK1651_RS09500	COG2274	protein secretion by the type I secretion system
HK1651_RS09505	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HK1651_RS09510	COG2994	toxin metabolic process
HK1651_RS09520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HK1651_RS09535	COG2813	Specifically methylates the guanine in position
HK1651_RS09540	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HK1651_RS09545	COG0456	acetyltransferase
HK1651_RS09550	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HK1651_RS09560	COG4795	General secretion pathway protein
HK1651_RS09565	COG2165	general secretion pathway protein
HK1651_RS09595	COG3064	Membrane
HK1651_RS09600	COG0848	biopolymer transport protein
HK1651_RS09605	COG0811	peptide transport
HK1651_RS09610	COG0824	Thioesterase
HK1651_RS09620	COG1294	oxidase, subunit
HK1651_RS09625	COG1271	oxidase subunit
HK1651_RS09650	COG0641	radical SAM
HK1651_RS09655	COG0217	transcriptional regulatory protein
HK1651_RS09660	COG0494	nUDIX hydrolase
HK1651_RS09670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HK1651_RS09675	COG1755	Isoprenylcysteine carboxyl methyltransferase
HK1651_RS09690	COG2271	Major facilitator Superfamily
HK1651_RS09700	COG0346	lactoylglutathione lyase activity
HK1651_RS09705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HK1651_RS09710	COG2056	Na+-H+ antiporter family
HK1651_RS09730	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HK1651_RS09735	COG0142	geranyltranstransferase activity
HK1651_RS09750	COG0697	spore germination
HK1651_RS09755	COG0697	spore germination
HK1651_RS09760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HK1651_RS09770	COG4166	transmembrane transport
HK1651_RS09775	COG0601	transmembrane transport
HK1651_RS09780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HK1651_RS09785	COG0444	Belongs to the ABC transporter superfamily
HK1651_RS09790	COG4608	Belongs to the ABC transporter superfamily
HK1651_RS09795	COG0745	RESPONSE REGULATOR receiver
HK1651_RS09800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HK1651_RS09810	COG1611	Belongs to the LOG family
HK1651_RS09820	COG2259	Doxx family
HK1651_RS09830	COG1530	ribonuclease E activity
HK1651_RS09845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HK1651_RS09850	COG0626	cystathionine gamma-synthase activity
HK1651_RS09885	COG2860	membrane
HK1651_RS09900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HK1651_RS09910	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HK1651_RS09915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HK1651_RS09920	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HK1651_RS09925	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HK1651_RS09935	COG0560	Phosphoserine phosphatase
HK1651_RS09950	COG0728	peptidoglycan biosynthetic process
HK1651_RS09955	COG0196	riboflavin kinase activity
HK1651_RS09965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HK1651_RS09980	COG4974	Belongs to the 'phage' integrase family
HK1651_RS09985	COG2814	Major facilitator Superfamily
HK1651_RS09990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HK1651_RS09995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HK1651_RS10010	COG3061	Opacity-associated protein A
HK1651_RS10010	COG3266	domain, Protein
HK1651_RS10015	COG1509	lysine 2,3-aminomutase activity
HK1651_RS10025	COG3033	Beta-eliminating lyase
HK1651_RS10030	COG0814	amino acid
HK1651_RS10035	COG2964	Protein conserved in bacteria
HK1651_RS10040	COG5413	integral membrane protein
HK1651_RS10050	COG0204	Acyl-transferase
HK1651_RS10060	COG0697	spore germination
HK1651_RS10065	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HK1651_RS10070	COG1882	Formate acetyltransferase
HK1651_RS10075	COG2116	formate transmembrane transporter activity
HK1651_RS10080	COG0537	adenosine 5'-monophosphoramidase activity
HK1651_RS10115	COG3022	response to hydroperoxide
HK1651_RS10120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HK1651_RS10135	COG0681	Belongs to the peptidase S26 family