locus-tag	class	description
CF65_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CF65_RS00010	COG0592	DNA-directed DNA polymerase activity
CF65_RS00020	COG2226	methyltransferase
CF65_RS00045	COG0281	malic enzyme
CF65_RS00075	COG0210	DNA helicase
CF65_RS00105	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CF65_RS00140	COG2081	HI0933 family
CF65_RS00145	COG4235	cytochrome complex assembly
CF65_RS00145	COG3088	subunit of a heme lyase
CF65_RS00150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CF65_RS00155	COG1138	Cytochrome C-type biogenesis protein
CF65_RS00160	COG3301	Polysulphide reductase, NrfD
CF65_RS00165	COG0437	4 iron, 4 sulfur cluster binding
CF65_RS00170	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CF65_RS00205	COG1138	Cytochrome C-type biogenesis protein
CF65_RS00215	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF65_RS00220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF65_RS00225	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF65_RS00230	COG4133	protoheme IX ABC transporter activity
CF65_RS00235	COG2814	Major facilitator Superfamily
CF65_RS00245	COG0281	malic enzyme
CF65_RS00245	COG0280	phosphate acetyltransferase
CF65_RS00260	COG2321	neutral zinc metallopeptidase
CF65_RS00275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CF65_RS00280	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CF65_RS00285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CF65_RS00300	COG0436	Aminotransferase
CF65_RS00310	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CF65_RS00315	COG2267	carboxylic ester hydrolase activity
CF65_RS00330	COG3091	SprT-like family
CF65_RS00335	COG0814	amino acid
CF65_RS00340	COG1760	l-serine dehydratase
CF65_RS00345	COG0252	asparaginase activity
CF65_RS00355	COG3063	Type IV pilus biogenesis stability protein PilW
CF65_RS00360	COG1426	Protein conserved in bacteria
CF65_RS00375	COG2976	Protein conserved in bacteria
CF65_RS00385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CF65_RS00390	COG2233	PERMEase
CF65_RS00395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CF65_RS00400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF65_RS00405	COG1181	Belongs to the D-alanine--D-alanine ligase family
CF65_RS00405	COG2918	glutathione biosynthetic process
CF65_RS00410	COG2194	sulfuric ester hydrolase activity
CF65_RS00415	COG0740	serine-type endopeptidase activity
CF65_RS00435	COG3739	integral membrane protein
CF65_RS00440	COG2217	Heavy metal translocating P-type atpase
CF65_RS00445	COG2608	mercury ion transmembrane transporter activity
CF65_RS00450	COG0789	Transcriptional regulator
CF65_RS00455	COG1720	tRNA m6t6A37 methyltransferase activity
CF65_RS00460	COG1575	Belongs to the MenA family. Type 1 subfamily
CF65_RS00470	COG0471	metal ion transport
CF65_RS00475	COG3028	Belongs to the UPF0307 family
CF65_RS00480	COG0312	modulator of DNA gyrase
CF65_RS00485	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CF65_RS00490	COG1929	Belongs to the glycerate kinase type-1 family
CF65_RS00495	COG2610	gluconate transmembrane transporter activity
CF65_RS00500	COG3835	regulator
CF65_RS00510	COG0513	Belongs to the DEAD box helicase family
CF65_RS00515	COG4785	May be involved in cell division
CF65_RS00525	COG2731	YhcH YjgK YiaL family protein
CF65_RS00530	COG3023	N-Acetylmuramoyl-L-alanine amidase
CF65_RS00535	COG4969	Belongs to the N-Me-Phe pilin family
CF65_RS00540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF65_RS00545	COG1459	type II secretion system
CF65_RS00555	COG0237	dephospho-CoA kinase activity
CF65_RS00555	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CF65_RS00560	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CF65_RS00570	COG1115	amino acid carrier protein
CF65_RS00575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CF65_RS00600	COG2184	nucleotidyltransferase activity
CF65_RS00605	COG4145	pantothenate transmembrane transporter activity
CF65_RS00610	COG3924	membrane
CF65_RS00615	COG4783	chaperone-mediated protein folding
CF65_RS00625	COG0439	Biotin carboxylase
CF65_RS00630	COG0511	ligase activity, forming carbon-carbon bonds
CF65_RS00655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CF65_RS00665	COG0456	acetyltransferase
CF65_RS00670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CF65_RS00680	COG3078	GTPase activator activity
CF65_RS00685	COG0590	tRNA wobble adenosine to inosine editing
CF65_RS00705	COG0730	response to heat
CF65_RS00715	COG1869	D-ribose catabolic process
CF65_RS00725	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF65_RS00730	COG1879	ABC-type sugar transport system periplasmic component
CF65_RS00735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF65_RS00740	COG1278	Cold shock
CF65_RS00775	COG0165	Argininosuccinate lyase
CF65_RS00780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CF65_RS00785	COG0753	catalase activity
CF65_RS00790	COG0587	DNA-directed DNA polymerase activity
CF65_RS00795	COG1022	Amp-dependent synthetase and ligase
CF65_RS00805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CF65_RS00805	COG1328	CTP reductase activity
CF65_RS00810	COG0602	queuosine metabolic process
CF65_RS00815	COG0084	hydrolase, TatD family'
CF65_RS00825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CF65_RS00850	COG1686	Belongs to the peptidase S11 family
CF65_RS00855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CF65_RS00855	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CF65_RS00860	COG0772	Belongs to the SEDS family
CF65_RS00865	COG0768	penicillin binding
CF65_RS00875	COG0799	negative regulation of ribosome biogenesis
CF65_RS00880	COG0513	Belongs to the DEAD box helicase family
CF65_RS00885	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CF65_RS00890	COG2814	Major facilitator Superfamily
CF65_RS00900	COG1028	Short-chain dehydrogenase reductase Sdr
CF65_RS00905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CF65_RS00915	COG0416	fatty acid biosynthetic process
CF65_RS00925	COG1399	metal-binding, possibly nucleic acid-binding protein
CF65_RS00935	COG0500	methyltransferase
CF65_RS00940	COG2830	Protein of unknown function (DUF452)
CF65_RS00950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CF65_RS00955	COG0688	phosphatidylethanolamine metabolic process
CF65_RS00960	COG0545	Peptidyl-prolyl cis-trans isomerase
CF65_RS00980	COG2966	Psort location CytoplasmicMembrane, score
CF65_RS00985	COG3610	response to peptide
CF65_RS00990	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CF65_RS00995	COG1253	flavin adenine dinucleotide binding
CF65_RS01005	COG0084	hydrolase, TatD family'
CF65_RS01010	COG0470	DNA polymerase III
CF65_RS01015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CF65_RS01020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CF65_RS01025	COG0347	Belongs to the P(II) protein family
CF65_RS01030	COG1349	DNA-binding transcription factor activity
CF65_RS01035	COG2084	Dehydrogenase
CF65_RS01040	COG3395	kinase activity
CF65_RS01045	COG0235	Class ii aldolase
CF65_RS01050	COG3622	Belongs to the hyi family
CF65_RS01060	COG0561	phosphatase activity
CF65_RS01085	COG3085	chromosome segregation
CF65_RS01090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF65_RS01095	COG3084	Protein conserved in bacteria
CF65_RS01100	COG0746	molybdenum cofactor guanylyltransferase activity
CF65_RS01110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF65_RS01110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF65_RS01115	COG1105	Belongs to the carbohydrate kinase PfkB family
CF65_RS01120	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CF65_RS01120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF65_RS01120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF65_RS01145	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CF65_RS01165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CF65_RS01190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CF65_RS01195	COG0255	Belongs to the universal ribosomal protein uL29 family
CF65_RS01200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CF65_RS01205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CF65_RS01210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CF65_RS01215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CF65_RS01220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CF65_RS01225	COG0089	rRNA binding
CF65_RS01230	COG0088	Forms part of the polypeptide exit tunnel
CF65_RS01235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CF65_RS01240	COG0051	transcription antitermination factor activity, RNA binding
CF65_RS01245	COG0583	DNA-binding transcription factor activity
CF65_RS01250	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CF65_RS01255	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CF65_RS01260	COG2031	fatty acid transporter
CF65_RS01265	COG0183	Belongs to the thiolase family
CF65_RS01275	COG1288	antiporter activity
CF65_RS01280	COG0549	Belongs to the carbamate kinase family
CF65_RS01285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CF65_RS01290	COG0038	chloride channel
CF65_RS01295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF65_RS01305	COG1522	sequence-specific DNA binding
CF65_RS01310	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CF65_RS01320	COG1393	Belongs to the ArsC family
CF65_RS01330	COG3036	rescue of stalled ribosome
CF65_RS01335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CF65_RS01340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CF65_RS01345	COG2841	Protein conserved in bacteria
CF65_RS01360	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CF65_RS01370	COG0569	domain protein
CF65_RS01375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CF65_RS01375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CF65_RS01415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CF65_RS01435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CF65_RS01440	COG2990	Protein conserved in bacteria
CF65_RS01470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CF65_RS01490	COG3501	Rhs element vgr protein
CF65_RS01560	COG0606	chelatase, subunit chli
CF65_RS01565	COG2861	carbohydrate metabolic process
CF65_RS01570	COG4942	peptidase
CF65_RS01575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CF65_RS01590	COG2853	Lipoprotein
CF65_RS01595	COG0747	negative chemotaxis
CF65_RS01625	COG0814	amino acid
CF65_RS01635	COG4783	chaperone-mediated protein folding
CF65_RS01640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CF65_RS01650	COG0552	protein localization to endoplasmic reticulum
CF65_RS01655	COG0742	ribosomal rna small subunit methyltransferase
CF65_RS01665	COG3715	PTS system
CF65_RS01670	COG3716	PTS system mannose fructose sorbose family IID component
CF65_RS01675	COG0561	phosphatase activity
CF65_RS01680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CF65_RS01695	COG1649	PFAM Uncharacterised BCR, COG1649
CF65_RS01695	COG0726	polysaccharide deacetylase
CF65_RS01700	COG1215	transferase activity, transferring glycosyl groups
CF65_RS01710	COG2271	Major facilitator Superfamily
CF65_RS01740	COG0513	Belongs to the DEAD box helicase family
CF65_RS01765	COG1238	metal cluster binding
CF65_RS01770	COG0110	maltose O-acetyltransferase activity
CF65_RS01775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF65_RS01800	COG0210	DNA helicase
CF65_RS01805	COG5645	(Lipo)protein
CF65_RS01815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CF65_RS01815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CF65_RS01830	COG0737	Belongs to the 5'-nucleotidase family
CF65_RS01840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF65_RS01850	COG0859	PFAM glycosyl transferase family 9
CF65_RS01860	COG3005	denitrification pathway
CF65_RS01865	COG3043	anaerobic respiration
CF65_RS01870	COG0348	domain, Protein
CF65_RS01875	COG0437	4 iron, 4 sulfur cluster binding
CF65_RS01880	COG0243	molybdopterin cofactor binding
CF65_RS01885	COG3062	negative regulation of establishment of protein localization
CF65_RS01890	COG3850	Histidine kinase
CF65_RS01895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CF65_RS01905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF65_RS01910	COG3070	regulator of competence-specific genes
CF65_RS01915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CF65_RS01930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CF65_RS01940	COG0583	DNA-binding transcription factor activity
CF65_RS01945	COG2962	Rard protein
CF65_RS01960	COG0551	DNA topoisomerase type I activity
CF65_RS01985	COG0705	Rhomboid family
CF65_RS02000	COG4178	(ABC) transporter
CF65_RS02015	COG0233	cytoplasmic translational termination
CF65_RS02030	COG0575	Belongs to the CDS family
CF65_RS02045	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CF65_RS02065	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CF65_RS02075	COG0471	metal ion transport
CF65_RS02075	COG0490	domain, Protein
CF65_RS02080	COG4589	Belongs to the CDS family
CF65_RS02085	COG0521	Mo-molybdopterin cofactor biosynthetic process
CF65_RS02120	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CF65_RS02120	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CF65_RS02125	COG0517	IMP dehydrogenase activity
CF65_RS02125	COG0516	GMP reductase activity
CF65_RS02135	COG2932	Transcriptional regulator
CF65_RS02140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CF65_RS02145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CF65_RS02155	COG2062	phosphohistidine phosphatase, SixA
CF65_RS02170	COG3100	YcgL domain-containing protein
CF65_RS02175	COG0791	NLP P60 protein
CF65_RS02185	COG2890	protein-(glutamine-N5) methyltransferase activity
CF65_RS02190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CF65_RS02195	COG3133	Outer membrane lipoprotein
CF65_RS02200	COG3102	Protein conserved in bacteria
CF65_RS02210	COG5339	Protein conserved in bacteria
CF65_RS02215	COG0443	Heat shock 70 kDa protein
CF65_RS02220	COG0484	heat shock protein binding
CF65_RS02240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CF65_RS02270	COG3021	interspecies interaction between organisms
CF65_RS02295	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CF65_RS02300	COG2999	glutathione oxidoreductase activity
CF65_RS02305	COG1530	ribonuclease E activity
CF65_RS02310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CF65_RS02360	COG1840	ABC-type Fe3 transport system, periplasmic component
CF65_RS02365	COG1840	ABC-type Fe3 transport system, periplasmic component
CF65_RS02390	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CF65_RS02395	COG1959	2 iron, 2 sulfur cluster binding
CF65_RS02405	COG0822	iron-sulfur transferase activity
CF65_RS02420	COG0443	Heat shock 70 kDa protein
CF65_RS02425	COG0633	Ferredoxin
CF65_RS02430	COG2975	iron-sulfur cluster assembly
CF65_RS02435	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CF65_RS02435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CF65_RS02440	COG0489	protein tyrosine kinase activity
CF65_RS02450	COG0105	UTP biosynthetic process
CF65_RS02470	COG4535	Mg2 and Co2 transporter CorC
CF65_RS02475	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CF65_RS02485	COG2301	Belongs to the HpcH HpaI aldolase family
CF65_RS02490	COG3051	citrate lyase alpha subunit
CF65_RS02495	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
CF65_RS02495	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CF65_RS02515	COG2017	converts alpha-aldose to the beta-anomer
CF65_RS02520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CF65_RS02525	COG1085	galactose-1-phosphate uridylyltransferase
CF65_RS02530	COG1609	Transcriptional regulator
CF65_RS02535	COG1879	ABC-type sugar transport system periplasmic component
CF65_RS02540	COG1129	ABC transporter
CF65_RS02545	COG4211	Belongs to the binding-protein-dependent transport system permease family
CF65_RS02550	COG5002	protein histidine kinase activity
CF65_RS02550	COG2198	Histidine kinase
CF65_RS02550	COG0784	Response regulator, receiver
CF65_RS02555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CF65_RS02570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CF65_RS02580	COG0497	DNA recombination
CF65_RS02585	COG3047	cAMP biosynthetic process
CF65_RS02600	COG1607	acyl-coa hydrolase
CF65_RS02605	COG2350	Protein conserved in bacteria
CF65_RS02610	COG0741	lytic transglycosylase activity
CF65_RS02620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CF65_RS02650	COG0582	viral genome integration into host DNA
CF65_RS02665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CF65_RS02670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CF65_RS02680	COG1408	metallophosphoesterase
CF65_RS02685	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CF65_RS02690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF65_RS02695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF65_RS02700	COG1120	ATPase activity
CF65_RS02710	COG1053	succinate dehydrogenase
CF65_RS02715	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CF65_RS02725	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CF65_RS02760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CF65_RS02765	COG0494	nUDIX hydrolase
CF65_RS02770	COG1876	peptidase activity
CF65_RS02780	COG1393	Belongs to the ArsC family
CF65_RS02785	COG0326	Molecular chaperone. Has ATPase activity
CF65_RS02790	COG1605	Chorismate mutase
CF65_RS02790	COG0077	Prephenate dehydratase
CF65_RS02800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CF65_RS02805	COG0849	cell division
CF65_RS02810	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CF65_RS02825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CF65_RS02835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CF65_RS02845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CF65_RS02855	COG0768	penicillin binding
CF65_RS02860	COG3116	cell division
CF65_RS02875	COG1966	Carbon starvation protein
CF65_RS02880	COG4160	amino acid transport
CF65_RS02885	COG4215	(ABC) transporter
CF65_RS02890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF65_RS02895	COG1126	abc transporter atp-binding protein
CF65_RS02905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CF65_RS02910	COG1444	tRNA N-acetyltransferase activity
CF65_RS02920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CF65_RS02945	COG4964	Belongs to the GSP D family
CF65_RS03015	COG0733	neurotransmitter:sodium symporter activity
CF65_RS03035	COG3276	selenocysteine insertion sequence binding
CF65_RS03040	COG1921	L-seryl-tRNASec selenium transferase activity
CF65_RS03045	COG0442	prolyl-tRNA aminoacylation
CF65_RS03050	COG2076	Multidrug Resistance protein
CF65_RS03060	COG1595	DNA-templated transcription, initiation
CF65_RS03065	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CF65_RS03070	COG3026	antisigma factor binding
CF65_RS03075	COG3086	response to oxidative stress
CF65_RS03080	COG1763	Mo-molybdopterin cofactor biosynthetic process
CF65_RS03085	COG0300	oxidoreductase activity
CF65_RS03090	COG2195	Cleaves the N-terminal amino acid of tripeptides
CF65_RS03100	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CF65_RS03105	COG2818	Glycosylase
CF65_RS03110	COG3477	response to acidic pH
CF65_RS03115	COG0019	diaminopimelate decarboxylase activity
CF65_RS03125	COG0514	ATP-dependent DNA helicase (RecQ)
CF65_RS03130	COG0187	DNA topoisomerase II activity
CF65_RS03135	COG1072	(Pantothenic acid kinase))
CF65_RS03160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CF65_RS03165	COG1879	ABC-type sugar transport system periplasmic component
CF65_RS03185	COG2183	response to ionizing radiation
CF65_RS03190	COG0583	DNA-binding transcription factor activity
CF65_RS03195	COG0471	metal ion transport
CF65_RS03205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF65_RS03215	COG1595	DNA-templated transcription, initiation
CF65_RS03225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CF65_RS03230	COG3071	HemY protein
CF65_RS03235	COG2959	enzyme of heme biosynthesis
CF65_RS03245	COG0181	hydroxymethylbilane synthase activity
CF65_RS03255	COG2197	response regulator
CF65_RS03260	COG0729	surface antigen
CF65_RS03265	COG2911	Protein conserved in bacteria
CF65_RS03270	COG0248	Ppx GppA phosphatase
CF65_RS03290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CF65_RS03295	COG3068	Protein conserved in bacteria
CF65_RS03305	COG1349	DNA-binding transcription factor activity
CF65_RS03310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CF65_RS03335	COG2272	Belongs to the type-B carboxylesterase lipase family
CF65_RS03340	COG0667	Aldo Keto reductase
CF65_RS03345	COG0656	L-ascorbic acid biosynthetic process
CF65_RS03360	COG0433	COG0433 Predicted ATPase
CF65_RS03365	COG2258	MOSC domain
CF65_RS03370	COG3012	SEC-C Motif Domain Protein
CF65_RS03385	COG0786	glutamate:sodium symporter activity
CF65_RS03390	COG2205	protein histidine kinase activity
CF65_RS03395	COG0745	RESPONSE REGULATOR receiver
CF65_RS03400	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF65_RS03410	COG3082	Protein of unknown function (DUF1414)
CF65_RS03415	COG3083	sulfuric ester hydrolase activity
CF65_RS03420	COG0402	S-adenosylhomocysteine deaminase activity
CF65_RS03425	COG3956	TIGRFAM MazG family protein
CF65_RS03440	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CF65_RS03445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CF65_RS03450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CF65_RS03455	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CF65_RS03460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CF65_RS03475	COG0148	phosphopyruvate hydratase activity
CF65_RS03485	COG2991	Protein conserved in bacteria
CF65_RS03490	COG1477	protein flavinylation
CF65_RS03495	COG2871	sodium ion transport
CF65_RS03500	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CF65_RS03505	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CF65_RS03510	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CF65_RS03525	COG0271	Belongs to the BolA IbaG family
CF65_RS03530	COG3056	Lipoprotein
CF65_RS03555	COG1194	a g-specific adenine glycosylase
CF65_RS03565	COG3171	Protein conserved in bacteria
CF65_RS03570	COG1840	ABC-type Fe3 transport system, periplasmic component
CF65_RS03575	COG1178	ABC-type Fe3 transport system permease component
CF65_RS03580	COG3842	ATPase activity
CF65_RS03590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF65_RS03600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CF65_RS03610	COG1561	YicC-like family, N-terminal region
CF65_RS03615	COG0354	folic acid binding
CF65_RS03630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CF65_RS03635	COG1381	Involved in DNA repair and RecF pathway recombination
CF65_RS03640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CF65_RS03645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CF65_RS03650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CF65_RS03665	COG0789	Transcriptional regulator
CF65_RS03670	COG4701	Protein of unknown function (DUF721)
CF65_RS03685	COG0494	nUDIX hydrolase
CF65_RS03690	COG1466	dna polymerase III delta subunit
CF65_RS03695	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CF65_RS03710	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
CF65_RS03715	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
CF65_RS03720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CF65_RS03725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CF65_RS03730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF65_RS03750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CF65_RS03755	COG4221	oxidoreductase activity
CF65_RS03765	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CF65_RS03770	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CF65_RS03775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CF65_RS03780	COG4137	Cytochrome C assembly protein
CF65_RS03785	COG4536	flavin adenine dinucleotide binding
CF65_RS03790	COG0811	peptide transport
CF65_RS03795	COG0848	biopolymer transport protein
CF65_RS03845	COG0243	molybdopterin cofactor binding
CF65_RS03850	COG0437	4 iron, 4 sulfur cluster binding
CF65_RS03855	COG3302	dmso reductase anchor subunit
CF65_RS03860	COG3381	protein complex oligomerization
CF65_RS03865	COG2221	Nitrite and sulphite reductase 4Fe-4S
CF65_RS03865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF65_RS03875	COG4545	Glutaredoxin-related protein
CF65_RS03900	COG0805	protein transport
CF65_RS03905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF65_RS03910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF65_RS03915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CF65_RS03920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CF65_RS03925	COG1011	Hydrolase
CF65_RS03930	COG0494	nUDIX hydrolase
CF65_RS03935	COG1917	Cupin 2, conserved barrel domain protein
CF65_RS03935	COG4977	sequence-specific DNA binding
CF65_RS03940	COG3059	membrane
CF65_RS03945	COG1297	OPT oligopeptide transporter protein
CF65_RS03955	COG1218	3'(2'),5'-bisphosphate nucleotidase
CF65_RS03960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CF65_RS03965	COG0363	glucosamine-6-phosphate deaminase activity
CF65_RS03975	COG1794	racemase activity, acting on amino acids and derivatives
CF65_RS03980	COG4545	Glutaredoxin-related protein
CF65_RS03995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CF65_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
CF65_RS04010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CF65_RS04065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CF65_RS04090	COG1011	Hydrolase
CF65_RS04100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CF65_RS04105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CF65_RS04125	COG1555	photosystem II stabilization
CF65_RS04125	COG1596	polysaccharide export
CF65_RS04130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CF65_RS04135	COG0561	phosphatase activity
CF65_RS04140	COG1040	competence protein
CF65_RS04150	COG0140	phosphoribosyl-ATP diphosphatase activity
CF65_RS04150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CF65_RS04155	COG1114	Component of the transport system for branched-chain amino acids
CF65_RS04180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CF65_RS04190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CF65_RS04200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CF65_RS04220	COG0201	protein transport
CF65_RS04235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CF65_RS04255	COG0814	amino acid
CF65_RS04265	COG3172	ATPase kinase involved in NAD metabolism
CF65_RS04275	COG1739	Uncharacterized protein family UPF0029
CF65_RS04285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CF65_RS04290	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CF65_RS04325	COG2801	Transposase and inactivated derivatives
CF65_RS04335	COG0859	PFAM glycosyl transferase family 9
CF65_RS04340	COG1027	Aspartate ammonia-lyase
CF65_RS04350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CF65_RS04355	COG0459	protein refolding
CF65_RS04385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CF65_RS04395	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CF65_RS04410	COG4796	Type ii and iii secretion system protein
CF65_RS04430	COG4972	Pilus assembly protein
CF65_RS04435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CF65_RS04440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CF65_RS04445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF65_RS04460	COG1309	transcriptional regulator
CF65_RS04470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CF65_RS04485	COG2932	Transcriptional regulator
CF65_RS04520	COG3306	glycosyltransferase involved in LPS biosynthesis
CF65_RS04530	COG3306	glycosyltransferase involved in LPS biosynthesis
CF65_RS04545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CF65_RS04550	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CF65_RS04555	COG1309	transcriptional regulator
CF65_RS04560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF65_RS04565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF65_RS04570	COG0500	methyltransferase
CF65_RS04580	COG0762	integral membrane protein
CF65_RS04590	COG0778	Nitroreductase
CF65_RS04595	COG1368	sulfuric ester hydrolase activity
CF65_RS04600	COG1496	oxidoreductase activity
CF65_RS04615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CF65_RS04630	COG0006	proline dipeptidase activity
CF65_RS04655	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CF65_RS04660	COG1792	Involved in formation and maintenance of cell shape
CF65_RS04665	COG1077	Cell shape determining protein MreB Mrl
CF65_RS04670	COG0557	exoribonuclease II activity
CF65_RS04680	COG2271	Major facilitator Superfamily
CF65_RS04685	COG0584	glycerophosphoryl diester phosphodiesterase
CF65_RS04690	COG0758	DNA mediated transformation
CF65_RS04725	COG1132	(ABC) transporter
CF65_RS04730	COG1917	Cupin 2, conserved barrel domain protein
CF65_RS04730	COG4977	sequence-specific DNA binding
CF65_RS04735	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF65_RS04740	COG0859	PFAM glycosyl transferase family 9
CF65_RS04755	COG1519	Transferase
CF65_RS04760	COG0463	Glycosyl transferase, family 2
CF65_RS04770	COG1388	LysM domain
CF65_RS04770	COG4942	peptidase
CF65_RS04780	COG1238	metal cluster binding
CF65_RS04810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CF65_RS04820	COG2884	Cell division ATP-binding protein ftsE
CF65_RS04825	COG2177	Part of the ABC transporter FtsEX involved in
CF65_RS04830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF65_RS04835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF65_RS04845	COG0561	phosphatase activity
CF65_RS04850	COG2267	carboxylic ester hydrolase activity
CF65_RS04855	COG3307	-O-antigen
CF65_RS04860	COG0191	fructose-bisphosphate aldolase activity
CF65_RS04870	COG3719	Belongs to the RNase T2 family
CF65_RS04875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF65_RS04880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CF65_RS04885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF65_RS04890	COG2801	Transposase and inactivated derivatives
CF65_RS04900	COG0582	viral genome integration into host DNA
CF65_RS04905	COG1070	Carbohydrate kinase
CF65_RS04910	COG2115	Belongs to the xylose isomerase family
CF65_RS04915	COG4213	ABC transporter substrate-binding protein
CF65_RS04920	COG1129	ABC transporter
CF65_RS04925	COG4214	carbohydrate transport
CF65_RS04930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CF65_RS04935	COG1757	Na H antiporter
CF65_RS04940	COG2207	Transcriptional regulator
CF65_RS04940	COG1609	Transcriptional regulator
CF65_RS04945	COG2814	Major facilitator Superfamily
CF65_RS04950	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF65_RS04950	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF65_RS04955	COG3715	PTS system
CF65_RS04960	COG3716	PTS system mannose fructose sorbose family IID component
CF65_RS04970	COG0732	type I restriction modification DNA specificity domain
CF65_RS04990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CF65_RS05005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CF65_RS05015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CF65_RS05035	COG3312	ion transport
CF65_RS05045	COG1733	regulation of RNA biosynthetic process
CF65_RS05050	COG0702	epimerase
CF65_RS05060	COG0716	FMN binding
CF65_RS05070	COG1494	fructose-1,6-bisphosphatase
CF65_RS05075	COG1045	serine acetyltransferase
CF65_RS05085	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CF65_RS05090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CF65_RS05095	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CF65_RS05100	COG4988	ABC transporter
CF65_RS05105	COG1132	(ABC) transporter
CF65_RS05110	COG1309	transcriptional regulator
CF65_RS05115	COG0583	DNA-binding transcription factor activity
CF65_RS05120	COG0678	peroxiredoxin activity
CF65_RS05120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF65_RS05125	COG2900	Belongs to the SlyX family
CF65_RS05130	COG0545	Peptidyl-prolyl cis-trans isomerase
CF65_RS05135	COG2964	Protein conserved in bacteria
CF65_RS05140	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CF65_RS05150	COG2168	tRNA wobble position uridine thiolation
CF65_RS05155	COG1126	abc transporter atp-binding protein
CF65_RS05160	COG0765	amino acid transport
CF65_RS05165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF65_RS05170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CF65_RS05190	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CF65_RS05200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CF65_RS05210	COG1349	DNA-binding transcription factor activity
CF65_RS05220	COG2963	transposase activity
CF65_RS05240	COG2095	MarC family integral membrane protein
CF65_RS05245	COG0488	(ABC) transporter
CF65_RS05250	COG0488	(ABC) transporter
CF65_RS05255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CF65_RS05260	COG2137	regulation of response to DNA damage stimulus
CF65_RS05265	COG0251	oxidation-reduction process
CF65_RS05275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CF65_RS05300	COG4172	Belongs to the ABC transporter superfamily
CF65_RS05305	COG4172	Belongs to the ABC transporter superfamily
CF65_RS05310	COG4171	peptide transport system, permease
CF65_RS05315	COG4168	peptide transport system, permease
CF65_RS05320	COG4166	transmembrane transport
CF65_RS05325	COG3106	COG3106 Predicted ATPase
CF65_RS05335	COG3283	Transcriptional regulator of aromatic amino acids metabolism
CF65_RS05350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CF65_RS05355	COG0860	N-Acetylmuramoyl-L-alanine amidase
CF65_RS05355	COG1388	LysM domain
CF65_RS05360	COG0802	atpase or kinase
CF65_RS05370	COG2246	polysaccharide biosynthetic process
CF65_RS05380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CF65_RS05390	COG2194	sulfuric ester hydrolase activity
CF65_RS05410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF65_RS05415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF65_RS05420	COG2190	(PTS) system
CF65_RS05425	COG0339	signal peptide processing
CF65_RS05430	COG2832	Protein of unknown function (DUF454)
CF65_RS05435	COG4166	transmembrane transport
CF65_RS05440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CF65_RS05450	COG0512	Glutamine amidotransferase of anthranilate synthase
CF65_RS05455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CF65_RS05460	COG4591	ABC-type transport system involved in lipoprotein release permease component
CF65_RS05470	COG4591	ABC-type transport system involved in lipoprotein release permease component
CF65_RS05475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF65_RS05480	COG0305	Participates in initiation and elongation during chromosome replication
CF65_RS05490	COG0166	Belongs to the GPI family
CF65_RS05495	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CF65_RS05505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CF65_RS05510	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CF65_RS05515	COG1280	lysine exporter protein (LysE YggA)
CF65_RS05525	COG0633	Ferredoxin
CF65_RS05535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF65_RS05545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF65_RS05555	COG1840	ABC-type Fe3 transport system, periplasmic component
CF65_RS05565	COG3842	ATPase activity
CF65_RS05570	COG0366	Alpha amylase catalytic
CF65_RS05575	COG3833	ABC-type maltose transport systems, permease component
CF65_RS05585	COG2182	Extracellular solute-binding protein
CF65_RS05590	COG3842	ATPase activity
CF65_RS05595	COG4580	involved in the transport of maltose and maltodextrins
CF65_RS05605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CF65_RS05610	COG0303	'Molybdopterin
CF65_RS05620	COG2027	D-alanyl-D-alanine carboxypeptidase
CF65_RS05625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF65_RS05630	COG1534	Rna-binding protein
CF65_RS05635	COG3657	addiction module killer protein
CF65_RS05640	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CF65_RS05645	COG0307	riboflavin synthase, alpha
CF65_RS05655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CF65_RS05660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CF65_RS05665	COG0725	ABC transporter, periplasmic molybdate-binding protein
CF65_RS05670	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CF65_RS05675	COG3842	ATPase activity
CF65_RS05695	COG2855	membrane
CF65_RS05700	COG4953	penicillin-binding protein 1C
CF65_RS05705	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CF65_RS05730	COG3623	hexulose-6-phosphate isomerase
CF65_RS05735	COG0235	Class ii aldolase
CF65_RS05740	COG0814	amino acid
CF65_RS05745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF65_RS05750	COG0778	Nitroreductase
CF65_RS05760	COG2268	Band 7 protein
CF65_RS05765	COG0114	fumarate hydratase activity
CF65_RS05770	COG2927	DNA polymerase III (CHI subunit)
CF65_RS05800	COG3550	peptidyl-serine autophosphorylation
CF65_RS05810	COG2814	Major facilitator Superfamily
CF65_RS05815	COG1566	PFAM secretion protein HlyD family protein
CF65_RS05820	COG0783	Belongs to the Dps family
CF65_RS05830	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CF65_RS05835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CF65_RS05840	COG0602	queuosine metabolic process
CF65_RS05845	COG0720	synthase
CF65_RS05850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CF65_RS05860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF65_RS05865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CF65_RS05870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF65_RS05875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CF65_RS05880	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
CF65_RS05885	COG0310	cobalt ion transport
CF65_RS05890	COG0310	cobalt ion transport
CF65_RS05895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CF65_RS05900	COG1122	ATPase activity
CF65_RS05905	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CF65_RS05910	COG0409	Hydrogenase expression formation protein
CF65_RS05915	COG0309	Hydrogenase expression formation protein (HypE)
CF65_RS05930	COG2801	Transposase and inactivated derivatives
CF65_RS05945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CF65_RS05950	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CF65_RS05955	COG0795	lipopolysaccharide-transporting ATPase activity
CF65_RS05960	COG0795	lipopolysaccharide-transporting ATPase activity
CF65_RS05965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CF65_RS05970	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CF65_RS05975	COG4149	molybdate abc transporter
CF65_RS05980	COG0725	ABC transporter, periplasmic molybdate-binding protein
CF65_RS05985	COG2005	Transcriptional regulator
CF65_RS05990	COG0471	metal ion transport
CF65_RS06000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF65_RS06005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF65_RS06005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF65_RS06010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CF65_RS06020	COG0583	DNA-binding transcription factor activity
CF65_RS06025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CF65_RS06035	COG0039	L-malate dehydrogenase activity
CF65_RS06040	COG1438	arginine binding
CF65_RS06045	COG1090	epimerase
CF65_RS06050	COG4657	Part of a membrane complex involved in electron transport
CF65_RS06080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CF65_RS06085	COG0733	neurotransmitter:sodium symporter activity
CF65_RS06090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CF65_RS06100	COG0739	heme binding
CF65_RS06105	COG4604	ABC transporter, ATP-binding protein
CF65_RS06110	COG4605	iron ion homeostasis
CF65_RS06115	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF65_RS06120	COG4607	ABC-type enterochelin transport system periplasmic component
CF65_RS06125	COG0737	Belongs to the 5'-nucleotidase family
CF65_RS06135	COG3111	PFAM Bacterial OB fold (BOF) protein
CF65_RS06140	COG0745	RESPONSE REGULATOR receiver
CF65_RS06170	COG0642	Histidine kinase
CF65_RS06175	COG0405	Gamma-glutamyltransferase
CF65_RS06190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF65_RS06195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CF65_RS06200	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
CF65_RS06230	COG4143	(ABC) transporter
CF65_RS06235	COG1178	ABC-type Fe3 transport system permease component
CF65_RS06240	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CF65_RS06250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF65_RS06255	COG3105	Protein conserved in bacteria
CF65_RS06260	COG1944	ATP diphosphatase activity
CF65_RS06270	COG3422	double-strand break repair
CF65_RS06285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CF65_RS06295	COG1846	Transcriptional regulator
CF65_RS06295	COG1940	carbohydrate kinase activity
CF65_RS06320	COG0563	adenylate kinase activity
CF65_RS06325	COG2814	Major facilitator Superfamily
CF65_RS06330	COG0375	protein maturation
CF65_RS06335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CF65_RS06340	COG3152	Membrane
CF65_RS06345	COG2252	PERMEase
CF65_RS06360	COG0825	malonyl-CoA metabolic process
CF65_RS06365	COG2351	hydroxyisourate hydrolase activity
CF65_RS06420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CF65_RS06445	COG3041	Addiction module toxin RelE StbE family
CF65_RS06450	COG3077	Addiction module antitoxin, RelB DinJ family
CF65_RS06455	COG3069	C4-dicarboxylate transmembrane transporter activity
CF65_RS06470	COG0195	Participates in both transcription termination and antitermination
CF65_RS06490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CF65_RS06495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CF65_RS06520	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CF65_RS06525	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CF65_RS06530	COG3177	Filamentation induced by cAMP protein fic
CF65_RS06540	COG3842	ATPase activity
CF65_RS06545	COG1175	transmembrane transport
CF65_RS06550	COG0395	ABC-type sugar transport system, permease component
CF65_RS06560	COG0322	excinuclease ABC activity
CF65_RS06570	COG2835	tetraacyldisaccharide 4'-kinase activity
CF65_RS06575	COG1663	tetraacyldisaccharide 4'-kinase activity
CF65_RS06580	COG1132	(ABC) transporter
CF65_RS06585	COG2333	competence protein COMEC
CF65_RS06585	COG0658	competence protein
CF65_RS06590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CF65_RS06595	COG0617	tRNA 3'-terminal CCA addition
CF65_RS06600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CF65_RS06610	COG0857	belongs to the CobB CobQ family
CF65_RS06610	COG0280	phosphate acetyltransferase
CF65_RS06615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CF65_RS06620	COG3092	negative regulation of chromosome organization
CF65_RS06625	COG1286	toxin biosynthetic process
CF65_RS06630	COG1640	4-alpha-glucanotransferase
CF65_RS06635	COG0058	SHG alpha-glucan phosphorylase activity
CF65_RS06640	COG2909	trisaccharide binding
CF65_RS06650	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CF65_RS06655	COG0508	dehydrogenase complex catalyzes the overall conversion of
CF65_RS06660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF65_RS06665	COG0778	Nitroreductase
CF65_RS06670	COG0616	signal peptide processing
CF65_RS06675	COG1605	Chorismate mutase
CF65_RS06675	COG0287	Prephenate dehydrogenase
CF65_RS06680	COG1605	Chorismate mutase
CF65_RS06680	COG0287	Prephenate dehydrogenase
CF65_RS06685	COG0009	L-threonylcarbamoyladenylate synthase
CF65_RS06695	COG0583	DNA-binding transcription factor activity
CF65_RS06705	COG3099	Belongs to the UPF0263 family
CF65_RS06715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CF65_RS06720	COG2949	membrane
CF65_RS06740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CF65_RS06745	COG0785	Cytochrome C biogenesis protein
CF65_RS06750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CF65_RS06750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CF65_RS06755	COG0288	reversible hydration of carbon dioxide
CF65_RS06765	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CF65_RS06770	COG0792	nuclease activity
CF65_RS06780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CF65_RS06790	COG1252	NADH dehydrogenase
CF65_RS06800	COG0616	signal peptide processing
CF65_RS06805	COG2885	chlorophyll binding
CF65_RS06805	COG3047	cAMP biosynthetic process
CF65_RS06830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CF65_RS06835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CF65_RS06840	COG3684	Belongs to the aldolase LacD family
CF65_RS06850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF65_RS06855	COG3414	Phosphotransferase system galactitol-specific IIB component
CF65_RS06860	COG3775	system Galactitol-specific IIC component
CF65_RS06865	COG1063	alcohol dehydrogenase
CF65_RS06870	COG1349	DNA-binding transcription factor activity
CF65_RS06880	COG0142	geranyltranstransferase activity
CF65_RS06895	COG0285	dihydrofolate synthase activity
CF65_RS06900	COG0406	alpha-ribazole phosphatase activity
CF65_RS06905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF65_RS06910	COG2431	L-lysine efflux transmembrane transporter activity
CF65_RS06915	COG0564	pseudouridine synthase activity
CF65_RS06925	COG2824	Alkylphosphonate utilization operon protein PhnA
CF65_RS06955	COG1538	Outer membrane efflux protein
CF65_RS06960	COG0577	efflux transmembrane transporter activity
CF65_RS06960	COG1136	(ABC) transporter
CF65_RS06965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF65_RS07005	COG0058	SHG alpha-glucan phosphorylase activity
CF65_RS07010	COG0586	Pfam SNARE associated Golgi protein
CF65_RS07015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CF65_RS07030	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CF65_RS07040	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CF65_RS07045	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CF65_RS07050	COG0697	spore germination
CF65_RS07055	COG2925	Exonuclease
CF65_RS07075	COG1528	Iron-storage protein
CF65_RS07080	COG1528	Iron-storage protein
CF65_RS07085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF65_RS07090	COG0589	response to stress
CF65_RS07095	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
CF65_RS07105	COG0613	PHP domain protein
CF65_RS07110	COG0167	dihydroorotate dehydrogenase activity
CF65_RS07115	COG0308	aminopeptidase N
CF65_RS07120	COG1448	Aminotransferase
CF65_RS07130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF65_RS07135	COG0842	Transport permease protein
CF65_RS07135	COG1129	ABC transporter
CF65_RS07140	COG0842	Transport permease protein
CF65_RS07150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF65_RS07180	COG1120	ATPase activity
CF65_RS07185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF65_RS07190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF65_RS07215	COG0791	NLP P60 protein
CF65_RS07230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CF65_RS07240	COG0517	IMP dehydrogenase activity
CF65_RS07240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CF65_RS07245	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CF65_RS07250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CF65_RS07255	COG0512	Glutamine amidotransferase of anthranilate synthase
CF65_RS07260	COG1942	4-Oxalocrotonate Tautomerase
CF65_RS07265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CF65_RS07275	COG3093	addiction module antidote protein HigA
CF65_RS07285	COG0298	carbon dioxide binding
CF65_RS07295	COG3630	sodium ion export across plasma membrane
CF65_RS07320	COG4221	oxidoreductase activity
CF65_RS07325	COG0133	tryptophan synthase activity
CF65_RS07335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF65_RS07345	COG0469	pyruvate kinase activity
CF65_RS07360	COG1879	ABC-type sugar transport system periplasmic component
CF65_RS07385	COG2390	Transcriptional regulator
CF65_RS07390	COG1070	Carbohydrate kinase
CF65_RS07395	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CF65_RS07400	COG1940	carbohydrate kinase activity
CF65_RS07410	COG2969	positive regulation of protein catabolic process
CF65_RS07420	COG0314	molybdopterin synthase activity
CF65_RS07425	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CF65_RS07435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CF65_RS07460	COG3005	denitrification pathway
CF65_RS07465	COG0243	molybdopterin cofactor binding
CF65_RS07470	COG2315	Protein conserved in bacteria
CF65_RS07475	COG0471	metal ion transport
CF65_RS07490	COG0101	tRNA pseudouridine synthase activity
CF65_RS07510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CF65_RS07515	COG1074	ATP-dependent DNA helicase activity
CF65_RS07520	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CF65_RS07530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CF65_RS07535	COG1067	ATP-dependent peptidase activity
CF65_RS07545	COG1278	Cold shock
CF65_RS07560	COG3098	single-species biofilm formation
CF65_RS07565	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CF65_RS07570	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CF65_RS07570	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CF65_RS07600	COG3101	peptidyl-lysine hydroxylation
CF65_RS07605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CF65_RS07615	COG0788	formyltetrahydrofolate deformylase activity
CF65_RS07620	COG2916	Histone family protein nucleoid-structuring protein H-NS
CF65_RS07625	COG1757	Na H antiporter
CF65_RS07660	COG3161	chorismate lyase activity
CF65_RS07670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CF65_RS07675	COG1758	RNA polymerase activity
CF65_RS07685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CF65_RS07695	COG2867	negative regulation of translational initiation
CF65_RS07705	COG2850	peptidyl-arginine hydroxylation
CF65_RS07720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF65_RS07725	COG1137	ATPase activity
CF65_RS07730	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CF65_RS07735	COG3117	lipopolysaccharide transmembrane transporter activity
CF65_RS07740	COG1127	ABC transporter
CF65_RS07745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CF65_RS07750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CF65_RS07755	COG2854	intermembrane phospholipid transfer
CF65_RS07760	COG3113	response to antibiotic
CF65_RS07765	COG5007	Belongs to the BolA IbaG family
CF65_RS07785	COG0463	Glycosyl transferase, family 2
CF65_RS07795	COG3691	Protein conserved in bacteria
CF65_RS07805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CF65_RS07815	COG0861	Integral membrane protein TerC family
CF65_RS07835	COG1217	gtp-binding protein TYPA
CF65_RS07845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CF65_RS07850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CF65_RS07865	COG0517	IMP dehydrogenase activity
CF65_RS07865	COG1125	glycine betaine transport
CF65_RS07870	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CF65_RS07880	COG0527	aspartate kinase activity
CF65_RS07880	COG0460	homoserine dehydrogenase
CF65_RS07895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CF65_RS07900	COG2091	lysine biosynthetic process via aminoadipic acid
CF65_RS07905	COG0330	HflC and HflK could
CF65_RS07910	COG0330	HflC and HflK could
CF65_RS07915	COG1555	photosystem II stabilization
CF65_RS07920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CF65_RS07930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CF65_RS07935	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CF65_RS07945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF65_RS07950	COG0800	Aldolase
CF65_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
CF65_RS07965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF65_RS07975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CF65_RS07990	COG2186	Transcriptional regulator
CF65_RS08010	COG0659	secondary active sulfate transmembrane transporter activity
CF65_RS08020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CF65_RS08035	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CF65_RS08040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CF65_RS08060	COG3115	cell septum assembly
CF65_RS08070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CF65_RS08075	COG1573	uracil-dna glycosylase
CF65_RS08080	COG0012	GTP binding
CF65_RS08085	COG0193	aminoacyl-tRNA hydrolase activity
CF65_RS08090	COG2801	Transposase and inactivated derivatives
CF65_RS08150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CF65_RS08155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CF65_RS08165	COG0024	Methionine aminopeptidase
CF65_RS08170	COG0316	Belongs to the HesB IscA family
CF65_RS08180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CF65_RS08185	COG0672	)-iron permease
CF65_RS08200	COG0577	efflux transmembrane transporter activity
CF65_RS08210	COG0577	efflux transmembrane transporter activity
CF65_RS08210	COG1136	(ABC) transporter
CF65_RS08215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CF65_RS08225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF65_RS08240	COG1643	Atp-dependent helicase
CF65_RS08245	COG2363	Small membrane protein
CF65_RS08265	COG0247	lactate metabolic process
CF65_RS08265	COG0277	FAD linked oxidase domain protein
CF65_RS08280	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CF65_RS08285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CF65_RS08290	COG0363	glucosamine-6-phosphate deaminase activity
CF65_RS08295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CF65_RS08300	COG1737	Transcriptional regulator
CF65_RS08310	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CF65_RS08315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CF65_RS08325	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CF65_RS08350	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CF65_RS08355	COG3683	transport system, periplasmic component
CF65_RS08360	COG0488	(ABC) transporter
CF65_RS08370	COG0187	DNA topoisomerase II activity
CF65_RS08375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CF65_RS08380	COG0625	glutathione transferase activity
CF65_RS08385	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CF65_RS08395	COG0251	oxidation-reduction process
CF65_RS08410	COG0463	Glycosyl transferase, family 2
CF65_RS08420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CF65_RS08430	COG1560	Kdo2-lipid A biosynthetic process
CF65_RS08435	COG0730	response to heat
CF65_RS08440	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CF65_RS08445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CF65_RS08450	COG3264	Mechanosensitive ion channel
CF65_RS08450	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CF65_RS08455	COG0318	PFAM AMP-dependent synthetase and ligase
CF65_RS08460	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CF65_RS08465	COG0596	Alpha beta hydrolase
CF65_RS08470	COG0716	FMN binding
CF65_RS08475	COG0735	belongs to the Fur family
CF65_RS08480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CF65_RS08485	COG3094	Invasion gene expression up-regulator, SirB
CF65_RS08490	COG0023	Translation Initiation Factor
CF65_RS08500	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CF65_RS08505	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CF65_RS08510	COG0776	regulation of translation
CF65_RS08515	COG0539	negative regulation of cytoplasmic translation
CF65_RS08525	COG2990	Protein conserved in bacteria
CF65_RS08530	COG4771	TonB-dependent receptor
CF65_RS08540	COG1687	branched-chain amino acid
CF65_RS08545	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CF65_RS08550	COG0583	DNA-binding transcription factor activity
CF65_RS08565	COG4804	nuclease activity
CF65_RS08570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CF65_RS08585	COG2920	part of a sulfur-relay system
CF65_RS08595	COG1121	(ABC) transporter
CF65_RS08600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CF65_RS08605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CF65_RS08625	COG3304	Inner membrane component domain
CF65_RS08630	COG1289	transmembrane transporter activity
CF65_RS08645	COG3958	Transketolase
CF65_RS08675	COG0488	(ABC) transporter
CF65_RS08685	COG1346	cytolysis
CF65_RS08700	COG1525	nuclease
CF65_RS08705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CF65_RS08710	COG2166	iron-sulfur cluster assembly
CF65_RS08715	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CF65_RS08715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CF65_RS08720	COG1560	Kdo2-lipid A biosynthetic process
CF65_RS08725	COG3381	protein complex oligomerization
CF65_RS08730	COG2249	NAD(P)H dehydrogenase (quinone) activity
CF65_RS08740	COG0330	HflC and HflK could
CF65_RS08765	COG1858	cytochrome C peroxidase
CF65_RS08770	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CF65_RS08775	COG0318	PFAM AMP-dependent synthetase and ligase
CF65_RS08780	COG3065	identical protein binding
CF65_RS08785	COG1214	PFAM Peptidase M22, glycoprotease
CF65_RS08790	COG1199	ATP-dependent helicase activity
CF65_RS08795	COG0676	glucose-6-phosphate 1-epimerase activity
CF65_RS08800	COG3118	belongs to the thioredoxin family
CF65_RS08805	COG0492	ferredoxin-NADP+ reductase activity
CF65_RS08810	COG4988	ABC transporter
CF65_RS08815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CF65_RS08820	COG1946	Acyl-CoA thioesterase
CF65_RS08825	COG0515	serine threonine protein kinase
CF65_RS08840	COG1940	carbohydrate kinase activity
CF65_RS08845	COG0671	phosphoesterase, PA-phosphatase related
CF65_RS08865	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CF65_RS08870	COG0708	Exodeoxyribonuclease III
CF65_RS08895	COG1216	Glycosyl transferase, family 2
CF65_RS08900	COG2246	polysaccharide biosynthetic process
CF65_RS08920	COG0463	Glycosyl transferase, family 2
CF65_RS08955	COG2951	lytic endotransglycosylase activity
CF65_RS08960	COG1216	Glycosyl transferase, family 2
CF65_RS08965	COG1216	Glycosyl transferase, family 2
CF65_RS08975	COG3306	glycosyltransferase involved in LPS biosynthesis
CF65_RS08985	COG5039	Polysaccharide pyruvyl transferase
CF65_RS08990	COG2161	toxin-antitoxin pair type II binding
CF65_RS08995	COG4115	mRNA cleavage
CF65_RS09000	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CF65_RS09005	COG1793	dna ligase
CF65_RS09010	COG0210	DNA helicase
CF65_RS09015	COG2610	gluconate transmembrane transporter activity
CF65_RS09020	COG3265	gluconokinase activity
CF65_RS09025	COG1609	Transcriptional regulator
CF65_RS09045	COG0437	4 iron, 4 sulfur cluster binding
CF65_RS09055	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CF65_RS09060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF65_RS09065	COG0651	ATP synthesis coupled electron transport
CF65_RS09070	COG0650	Formate hydrogenlyase subunit 4
CF65_RS09075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CF65_RS09080	COG4237	Hydrogenase 4 membrane
CF65_RS09085	COG0651	ATP synthesis coupled electron transport
CF65_RS09090	COG3261	NADH dehydrogenase
CF65_RS09090	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CF65_RS09095	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF65_RS09100	COG3260	NADH ubiquinone oxidoreductase 20
CF65_RS09110	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CF65_RS09115	COG3383	formate dehydrogenase (NAD+) activity
CF65_RS09120	COG3383	formate dehydrogenase (NAD+) activity
CF65_RS09125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF65_RS09135	COG0508	dehydrogenase complex catalyzes the overall conversion of
CF65_RS09140	COG0567	Dehydrogenase, E1 component
CF65_RS09145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CF65_RS09150	COG3108	Peptidase M15
CF65_RS09155	COG2989	Protein conserved in bacteria
CF65_RS09160	COG0793	Belongs to the peptidase S41A family
CF65_RS09170	COG2995	paraquat-inducible protein a
CF65_RS09175	COG3008	intermembrane lipid transfer
CF65_RS09185	COG3842	ATPase activity
CF65_RS09190	COG1176	ABC-type spermidine putrescine transport system, permease component I
CF65_RS09195	COG1177	transmembrane transport
CF65_RS09200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CF65_RS09215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CF65_RS09220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CF65_RS09235	COG1522	sequence-specific DNA binding
CF65_RS09240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CF65_RS09245	COG3025	triphosphatase activity
CF65_RS09250	COG1392	Phosphate transport regulator
CF65_RS09255	COG0306	phosphate transporter
CF65_RS09260	COG4991	sh3 domain protein
CF65_RS09265	COG0617	tRNA 3'-terminal CCA addition
CF65_RS09270	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CF65_RS09275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CF65_RS09290	COG1620	l-lactate permease
CF65_RS09310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CF65_RS09315	COG0328	RNA-DNA hybrid ribonuclease activity
CF65_RS09350	COG0826	peptidase U32
CF65_RS09360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CF65_RS09370	COG1862	Preprotein translocase
CF65_RS09375	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CF65_RS09380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CF65_RS09390	COG1454	alcohol dehydrogenase
CF65_RS09390	COG1012	belongs to the aldehyde dehydrogenase family
CF65_RS09395	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF65_RS09400	COG1129	ABC transporter
CF65_RS09415	COG0673	inositol 2-dehydrogenase activity
CF65_RS09425	COG2271	Major facilitator Superfamily
CF65_RS09435	COG3718	enzyme involved in inositol metabolism
CF65_RS09445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF65_RS09450	COG3962	Belongs to the TPP enzyme family
CF65_RS09460	COG0673	inositol 2-dehydrogenase activity
CF65_RS09465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF65_RS09470	COG2274	protein secretion by the type I secretion system
CF65_RS09475	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CF65_RS09480	COG2994	toxin metabolic process
CF65_RS09490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CF65_RS09505	COG2813	Specifically methylates the guanine in position
CF65_RS09510	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CF65_RS09515	COG0456	acetyltransferase
CF65_RS09520	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CF65_RS09530	COG4795	General secretion pathway protein
CF65_RS09535	COG2165	general secretion pathway protein
CF65_RS09565	COG3064	Membrane
CF65_RS09570	COG0848	biopolymer transport protein
CF65_RS09575	COG0811	peptide transport
CF65_RS09580	COG0824	Thioesterase
CF65_RS09590	COG1294	oxidase, subunit
CF65_RS09595	COG1271	oxidase subunit
CF65_RS09620	COG0641	radical SAM
CF65_RS09625	COG0217	transcriptional regulatory protein
CF65_RS09630	COG0494	nUDIX hydrolase
CF65_RS09640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CF65_RS09645	COG1755	Isoprenylcysteine carboxyl methyltransferase
CF65_RS09660	COG2271	Major facilitator Superfamily
CF65_RS09670	COG0346	lactoylglutathione lyase activity
CF65_RS09675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF65_RS09680	COG2056	Na+-H+ antiporter family
CF65_RS09700	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CF65_RS09705	COG0142	geranyltranstransferase activity
CF65_RS09720	COG0697	spore germination
CF65_RS09725	COG0697	spore germination
CF65_RS09730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CF65_RS09750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF65_RS09755	COG0444	Belongs to the ABC transporter superfamily
CF65_RS09760	COG4608	Belongs to the ABC transporter superfamily
CF65_RS09765	COG0745	RESPONSE REGULATOR receiver
CF65_RS09770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CF65_RS09780	COG1611	Belongs to the LOG family
CF65_RS09790	COG2259	Doxx family
CF65_RS09800	COG1530	ribonuclease E activity
CF65_RS09815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CF65_RS09820	COG0626	cystathionine gamma-synthase activity
CF65_RS09840	COG3451	type IV secretory pathway VirB4
CF65_RS09860	COG2860	membrane
CF65_RS09875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CF65_RS09885	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CF65_RS09890	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CF65_RS09895	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CF65_RS09900	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CF65_RS09910	COG0560	Phosphoserine phosphatase
CF65_RS09925	COG0728	peptidoglycan biosynthetic process
CF65_RS09930	COG0196	riboflavin kinase activity
CF65_RS09940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CF65_RS09955	COG4974	Belongs to the 'phage' integrase family
CF65_RS09960	COG2814	Major facilitator Superfamily
CF65_RS09965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CF65_RS09970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CF65_RS09985	COG3061	Opacity-associated protein A
CF65_RS09985	COG3266	domain, Protein
CF65_RS09990	COG1509	lysine 2,3-aminomutase activity
CF65_RS10005	COG0814	amino acid
CF65_RS10010	COG2964	Protein conserved in bacteria
CF65_RS10015	COG5413	integral membrane protein
CF65_RS10025	COG0204	Acyl-transferase
CF65_RS10035	COG0697	spore germination
CF65_RS10040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF65_RS10045	COG1882	Formate acetyltransferase
CF65_RS10050	COG2116	formate transmembrane transporter activity
CF65_RS10055	COG0537	adenosine 5'-monophosphoramidase activity
CF65_RS10090	COG3022	response to hydroperoxide
CF65_RS10095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CF65_RS10110	COG0681	Belongs to the peptidase S26 family
CF65_RS10150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF65_RS10150	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF65_RS10165	COG2184	nucleotidyltransferase activity