locus-tag	class	description
FXN58_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXN58_RS00010	COG0592	DNA-directed DNA polymerase activity
FXN58_RS00020	COG2226	methyltransferase
FXN58_RS00035	COG0281	malic enzyme
FXN58_RS00040	COG2081	HI0933 family
FXN58_RS00045	COG4235	cytochrome complex assembly
FXN58_RS00045	COG3088	subunit of a heme lyase
FXN58_RS00050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN58_RS00055	COG1138	Cytochrome C-type biogenesis protein
FXN58_RS00065	COG3301	Polysulphide reductase, NrfD
FXN58_RS00070	COG0437	4 iron, 4 sulfur cluster binding
FXN58_RS00075	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FXN58_RS00110	COG1138	Cytochrome C-type biogenesis protein
FXN58_RS00120	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN58_RS00125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN58_RS00130	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN58_RS00135	COG4133	protoheme IX ABC transporter activity
FXN58_RS00180	COG2267	carboxylic ester hydrolase activity
FXN58_RS00185	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FXN58_RS00195	COG0436	Aminotransferase
FXN58_RS00210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FXN58_RS00215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FXN58_RS00220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FXN58_RS00230	COG1652	LysM domain
FXN58_RS00235	COG2321	neutral zinc metallopeptidase
FXN58_RS00245	COG3293	Transposase
FXN58_RS00255	COG0281	malic enzyme
FXN58_RS00255	COG0280	phosphate acetyltransferase
FXN58_RS00335	COG3293	Transposase
FXN58_RS00345	COG2801	Transposase and inactivated derivatives
FXN58_RS00350	COG3091	SprT-like family
FXN58_RS00355	COG0814	amino acid
FXN58_RS00360	COG1760	l-serine dehydratase
FXN58_RS00365	COG0252	asparaginase activity
FXN58_RS00375	COG3063	Type IV pilus biogenesis stability protein PilW
FXN58_RS00380	COG1426	Protein conserved in bacteria
FXN58_RS00395	COG2976	Protein conserved in bacteria
FXN58_RS00405	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXN58_RS00410	COG2233	PERMEase
FXN58_RS00415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FXN58_RS00420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXN58_RS00425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FXN58_RS00435	COG0659	secondary active sulfate transmembrane transporter activity
FXN58_RS00455	COG2186	Transcriptional regulator
FXN58_RS00470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FXN58_RS00480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXN58_RS00495	COG0800	Aldolase
FXN58_RS00500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FXN58_RS00510	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FXN58_RS00515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FXN58_RS00525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FXN58_RS00530	COG1555	photosystem II stabilization
FXN58_RS00540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FXN58_RS00560	COG0196	riboflavin kinase activity
FXN58_RS00565	COG0728	peptidoglycan biosynthetic process
FXN58_RS00580	COG0560	Phosphoserine phosphatase
FXN58_RS00590	COG0193	aminoacyl-tRNA hydrolase activity
FXN58_RS00595	COG0012	GTP binding
FXN58_RS00605	COG1573	uracil-dna glycosylase
FXN58_RS00610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FXN58_RS00620	COG3115	cell septum assembly
FXN58_RS00640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FXN58_RS00645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FXN58_RS00680	COG2801	Transposase and inactivated derivatives
FXN58_RS00725	COG3161	chorismate lyase activity
FXN58_RS00735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXN58_RS00740	COG1758	RNA polymerase activity
FXN58_RS00750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FXN58_RS00785	COG2801	Transposase and inactivated derivatives
FXN58_RS00790	COG3293	Transposase
FXN58_RS00810	COG2271	Major facilitator Superfamily
FXN58_RS00820	COG1215	transferase activity, transferring glycosyl groups
FXN58_RS00825	COG0726	polysaccharide deacetylase
FXN58_RS00825	COG1649	PFAM Uncharacterised BCR, COG1649
FXN58_RS00840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FXN58_RS00845	COG0561	phosphatase activity
FXN58_RS00850	COG3716	PTS system mannose fructose sorbose family IID component
FXN58_RS00860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN58_RS00860	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN58_RS00865	COG0742	ribosomal rna small subunit methyltransferase
FXN58_RS00870	COG0552	protein localization to endoplasmic reticulum
FXN58_RS00875	COG2884	Cell division ATP-binding protein ftsE
FXN58_RS00880	COG2177	Part of the ABC transporter FtsEX involved in
FXN58_RS00910	COG1575	Belongs to the MenA family. Type 1 subfamily
FXN58_RS00920	COG3293	Transposase
FXN58_RS00930	COG3028	Belongs to the UPF0307 family
FXN58_RS00935	COG0312	modulator of DNA gyrase
FXN58_RS00940	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FXN58_RS00945	COG1929	Belongs to the glycerate kinase type-1 family
FXN58_RS00960	COG2801	Transposase and inactivated derivatives
FXN58_RS00970	COG0513	Belongs to the DEAD box helicase family
FXN58_RS00975	COG4785	May be involved in cell division
FXN58_RS00985	COG2731	YhcH YjgK YiaL family protein
FXN58_RS00990	COG3023	N-Acetylmuramoyl-L-alanine amidase
FXN58_RS00995	COG4969	Belongs to the N-Me-Phe pilin family
FXN58_RS01040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FXN58_RS01060	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FXN58_RS01080	COG2932	Transcriptional regulator
FXN58_RS01100	COG0789	Transcriptional regulator
FXN58_RS01105	COG2608	mercury ion transmembrane transporter activity
FXN58_RS01110	COG2217	Heavy metal translocating P-type atpase
FXN58_RS01135	COG0740	serine-type endopeptidase activity
FXN58_RS01140	COG2194	sulfuric ester hydrolase activity
FXN58_RS01145	COG1181	Belongs to the D-alanine--D-alanine ligase family
FXN58_RS01145	COG2918	glutathione biosynthetic process
FXN58_RS01170	COG2801	Transposase and inactivated derivatives
FXN58_RS01190	COG0237	dephospho-CoA kinase activity
FXN58_RS01190	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FXN58_RS01195	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FXN58_RS01205	COG1115	amino acid carrier protein
FXN58_RS01210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FXN58_RS01245	COG4145	pantothenate transmembrane transporter activity
FXN58_RS01250	COG3924	membrane
FXN58_RS01255	COG4783	chaperone-mediated protein folding
FXN58_RS01265	COG3293	Transposase
FXN58_RS01270	COG0439	Biotin carboxylase
FXN58_RS01275	COG0511	ligase activity, forming carbon-carbon bonds
FXN58_RS01300	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FXN58_RS01310	COG0456	acetyltransferase
FXN58_RS01315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FXN58_RS01325	COG3078	GTPase activator activity
FXN58_RS01330	COG3293	Transposase
FXN58_RS01335	COG3501	Rhs element vgr protein
FXN58_RS01345	COG3201	nicotinamide mononucleotide transporter
FXN58_RS01355	COG0513	Belongs to the DEAD box helicase family
FXN58_RS01395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FXN58_RS01405	COG0251	oxidation-reduction process
FXN58_RS01410	COG2137	regulation of response to DNA damage stimulus
FXN58_RS01415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FXN58_RS01420	COG0488	(ABC) transporter
FXN58_RS01470	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
FXN58_RS01500	COG1238	metal cluster binding
FXN58_RS01505	COG0110	maltose O-acetyltransferase activity
FXN58_RS01510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FXN58_RS01530	COG0210	DNA helicase
FXN58_RS01535	COG5645	(Lipo)protein
FXN58_RS01545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FXN58_RS01545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FXN58_RS01555	COG3293	Transposase
FXN58_RS01560	COG0243	molybdopterin cofactor binding
FXN58_RS01575	COG3293	Transposase
FXN58_RS01580	COG3381	protein complex oligomerization
FXN58_RS01585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXN58_RS01585	COG2221	Nitrite and sulphite reductase 4Fe-4S
FXN58_RS01595	COG4545	Glutaredoxin-related protein
FXN58_RS01610	COG3293	Transposase
FXN58_RS01630	COG1114	Component of the transport system for branched-chain amino acids
FXN58_RS01640	COG3293	Transposase
FXN58_RS01660	COG0561	phosphatase activity
FXN58_RS01665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FXN58_RS01670	COG1596	polysaccharide export
FXN58_RS01670	COG1555	photosystem II stabilization
FXN58_RS01690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FXN58_RS01695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FXN58_RS01730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FXN58_RS01785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN58_RS01795	COG1028	Short-chain dehydrogenase reductase Sdr
FXN58_RS01800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN58_RS01825	COG0737	Belongs to the 5'-nucleotidase family
FXN58_RS01835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN58_RS01845	COG0859	PFAM glycosyl transferase family 9
FXN58_RS01850	COG0754	glutathionylspermidine amidase activity
FXN58_RS01855	COG3005	denitrification pathway
FXN58_RS01860	COG3043	anaerobic respiration
FXN58_RS01865	COG0348	domain, Protein
FXN58_RS01870	COG0437	4 iron, 4 sulfur cluster binding
FXN58_RS01875	COG0243	molybdopterin cofactor binding
FXN58_RS01880	COG3062	negative regulation of establishment of protein localization
FXN58_RS01885	COG3850	Histidine kinase
FXN58_RS01890	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FXN58_RS01900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FXN58_RS01915	COG0582	viral genome integration into host DNA
FXN58_RS01925	COG1070	Carbohydrate kinase
FXN58_RS01930	COG2115	Belongs to the xylose isomerase family
FXN58_RS01935	COG4213	ABC transporter substrate-binding protein
FXN58_RS01940	COG1129	ABC transporter
FXN58_RS01945	COG4214	carbohydrate transport
FXN58_RS01950	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FXN58_RS01955	COG1757	Na H antiporter
FXN58_RS01960	COG2207	Transcriptional regulator
FXN58_RS01960	COG1609	Transcriptional regulator
FXN58_RS01970	COG0297	glycogen (starch) synthase activity
FXN58_RS01980	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FXN58_RS01990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN58_RS02010	COG0662	Cupin 2, conserved barrel domain protein
FXN58_RS02010	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FXN58_RS02015	COG2814	Major facilitator Superfamily
FXN58_RS02020	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN58_RS02020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN58_RS02025	COG3715	PTS system
FXN58_RS02030	COG3716	PTS system mannose fructose sorbose family IID component
FXN58_RS02045	COG0859	PFAM glycosyl transferase family 9
FXN58_RS02050	COG1027	Aspartate ammonia-lyase
FXN58_RS02060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FXN58_RS02065	COG0459	protein refolding
FXN58_RS02095	COG3293	Transposase
FXN58_RS02105	COG3293	Transposase
FXN58_RS02110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FXN58_RS02120	COG0688	phosphatidylethanolamine metabolic process
FXN58_RS02135	COG2830	Protein of unknown function (DUF452)
FXN58_RS02150	COG1399	metal-binding, possibly nucleic acid-binding protein
FXN58_RS02160	COG0416	fatty acid biosynthetic process
FXN58_RS02170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FXN58_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
FXN58_RS02185	COG2814	Major facilitator Superfamily
FXN58_RS02190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FXN58_RS02195	COG0513	Belongs to the DEAD box helicase family
FXN58_RS02200	COG0799	negative regulation of ribosome biogenesis
FXN58_RS02210	COG0768	penicillin binding
FXN58_RS02215	COG0772	Belongs to the SEDS family
FXN58_RS02220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN58_RS02220	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN58_RS02225	COG1686	Belongs to the peptidase S11 family
FXN58_RS02255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN58_RS02260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN58_RS02265	COG0765	amino acid transport
FXN58_RS02270	COG1126	abc transporter atp-binding protein
FXN58_RS02275	COG2168	tRNA wobble position uridine thiolation
FXN58_RS02285	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FXN58_RS02290	COG2964	Protein conserved in bacteria
FXN58_RS02295	COG0545	Peptidyl-prolyl cis-trans isomerase
FXN58_RS02300	COG2900	Belongs to the SlyX family
FXN58_RS02305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FXN58_RS02305	COG0678	peroxiredoxin activity
FXN58_RS02310	COG0583	DNA-binding transcription factor activity
FXN58_RS02315	COG1309	transcriptional regulator
FXN58_RS02320	COG1132	(ABC) transporter
FXN58_RS02325	COG4988	ABC transporter
FXN58_RS02330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FXN58_RS02335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXN58_RS02340	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FXN58_RS02350	COG1045	serine acetyltransferase
FXN58_RS02360	COG1494	fructose-1,6-bisphosphatase
FXN58_RS02370	COG0716	FMN binding
FXN58_RS02385	COG1733	regulation of RNA biosynthetic process
FXN58_RS02395	COG3312	ion transport
FXN58_RS02415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FXN58_RS02425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FXN58_RS02440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN58_RS02445	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FXN58_RS02455	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FXN58_RS02475	COG3293	Transposase
FXN58_RS02505	COG3293	Transposase
FXN58_RS02510	COG4783	chaperone-mediated protein folding
FXN58_RS02520	COG0814	amino acid
FXN58_RS02555	COG0747	negative chemotaxis
FXN58_RS02560	COG2853	Lipoprotein
FXN58_RS02630	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FXN58_RS02635	COG3610	response to peptide
FXN58_RS02640	COG2966	Psort location CytoplasmicMembrane, score
FXN58_RS02645	COG3293	Transposase
FXN58_RS02655	COG0848	biopolymer transport protein
FXN58_RS02660	COG0811	peptide transport
FXN58_RS02665	COG4536	flavin adenine dinucleotide binding
FXN58_RS02670	COG4137	Cytochrome C assembly protein
FXN58_RS02675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FXN58_RS02690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FXN58_RS02695	COG0789	Transcriptional regulator
FXN58_RS02700	COG4221	oxidoreductase activity
FXN58_RS02710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FXN58_RS02730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXN58_RS02735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FXN58_RS02740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FXN58_RS02745	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
FXN58_RS02750	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
FXN58_RS02765	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FXN58_RS02770	COG1466	dna polymerase III delta subunit
FXN58_RS02775	COG0494	nUDIX hydrolase
FXN58_RS02790	COG4701	Protein of unknown function (DUF721)
FXN58_RS02795	COG0789	Transcriptional regulator
FXN58_RS02800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FXN58_RS02820	COG3293	Transposase
FXN58_RS02835	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FXN58_RS02850	COG4796	Type ii and iii secretion system protein
FXN58_RS02870	COG4972	Pilus assembly protein
FXN58_RS02875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FXN58_RS02880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FXN58_RS02885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXN58_RS02900	COG1309	transcriptional regulator
FXN58_RS02910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FXN58_RS02945	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN58_RS02955	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN58_RS02970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FXN58_RS02980	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN58_RS02985	COG1309	transcriptional regulator
FXN58_RS02990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN58_RS02995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXN58_RS03010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FXN58_RS03015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXN58_RS03020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FXN58_RS03025	COG1381	Involved in DNA repair and RecF pathway recombination
FXN58_RS03030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FXN58_RS03050	COG0354	folic acid binding
FXN58_RS03055	COG1561	YicC-like family, N-terminal region
FXN58_RS03065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FXN58_RS03080	COG3842	ATPase activity
FXN58_RS03085	COG1178	ABC-type Fe3 transport system permease component
FXN58_RS03090	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN58_RS03095	COG3171	Protein conserved in bacteria
FXN58_RS03105	COG1194	a g-specific adenine glycosylase
FXN58_RS03130	COG3056	Lipoprotein
FXN58_RS03135	COG0271	Belongs to the BolA IbaG family
FXN58_RS03150	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN58_RS03155	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN58_RS03160	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN58_RS03165	COG2871	sodium ion transport
FXN58_RS03170	COG1477	protein flavinylation
FXN58_RS03175	COG2991	Protein conserved in bacteria
FXN58_RS03190	COG0148	phosphopyruvate hydratase activity
FXN58_RS03205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FXN58_RS03210	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
FXN58_RS03215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FXN58_RS03225	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FXN58_RS03240	COG3956	TIGRFAM MazG family protein
FXN58_RS03245	COG0402	S-adenosylhomocysteine deaminase activity
FXN58_RS03250	COG3083	sulfuric ester hydrolase activity
FXN58_RS03255	COG3082	Protein of unknown function (DUF1414)
FXN58_RS03265	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FXN58_RS03270	COG0745	RESPONSE REGULATOR receiver
FXN58_RS03275	COG2205	protein histidine kinase activity
FXN58_RS03280	COG0786	glutamate:sodium symporter activity
FXN58_RS03300	COG2258	MOSC domain
FXN58_RS03315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FXN58_RS03320	COG1349	DNA-binding transcription factor activity
FXN58_RS03330	COG3068	Protein conserved in bacteria
FXN58_RS03335	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FXN58_RS03355	COG0248	Ppx GppA phosphatase
FXN58_RS03360	COG2911	Protein conserved in bacteria
FXN58_RS03365	COG0729	surface antigen
FXN58_RS03370	COG2197	response regulator
FXN58_RS03380	COG0181	hydroxymethylbilane synthase activity
FXN58_RS03390	COG2959	enzyme of heme biosynthesis
FXN58_RS03395	COG3071	HemY protein
FXN58_RS03400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FXN58_RS03410	COG1595	DNA-templated transcription, initiation
FXN58_RS03420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXN58_RS03425	COG2183	response to ionizing radiation
FXN58_RS03435	COG0471	metal ion transport
FXN58_RS03440	COG0583	DNA-binding transcription factor activity
FXN58_RS03445	COG2183	response to ionizing radiation
FXN58_RS03450	COG3293	Transposase
FXN58_RS03460	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXN58_RS03465	COG1129	ABC transporter
FXN58_RS03470	COG1879	ABC-type sugar transport system periplasmic component
FXN58_RS03475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FXN58_RS03490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FXN58_RS03500	COG0583	DNA-binding transcription factor activity
FXN58_RS03505	COG2962	Rard protein
FXN58_RS03520	COG0551	DNA topoisomerase type I activity
FXN58_RS03545	COG0705	Rhomboid family
FXN58_RS03550	COG1349	DNA-binding transcription factor activity
FXN58_RS03565	COG4178	(ABC) transporter
FXN58_RS03580	COG0233	cytoplasmic translational termination
FXN58_RS03595	COG0575	Belongs to the CDS family
FXN58_RS03610	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FXN58_RS03630	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXN58_RS03640	COG0471	metal ion transport
FXN58_RS03640	COG0490	domain, Protein
FXN58_RS03645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FXN58_RS03655	COG4589	Belongs to the CDS family
FXN58_RS03660	COG0521	Mo-molybdopterin cofactor biosynthetic process
FXN58_RS03680	COG3276	selenocysteine insertion sequence binding
FXN58_RS03685	COG1921	L-seryl-tRNASec selenium transferase activity
FXN58_RS03690	COG0442	prolyl-tRNA aminoacylation
FXN58_RS03705	COG1595	DNA-templated transcription, initiation
FXN58_RS03710	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FXN58_RS03715	COG3026	antisigma factor binding
FXN58_RS03720	COG3086	response to oxidative stress
FXN58_RS03725	COG1763	Mo-molybdopterin cofactor biosynthetic process
FXN58_RS03730	COG0300	oxidoreductase activity
FXN58_RS03735	COG2195	Cleaves the N-terminal amino acid of tripeptides
FXN58_RS03745	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FXN58_RS03750	COG2818	Glycosylase
FXN58_RS03755	COG3477	response to acidic pH
FXN58_RS03760	COG0019	diaminopimelate decarboxylase activity
FXN58_RS03775	COG0514	ATP-dependent DNA helicase (RecQ)
FXN58_RS03780	COG0187	DNA topoisomerase II activity
FXN58_RS03785	COG1072	(Pantothenic acid kinase))
FXN58_RS03810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FXN58_RS03825	COG0561	phosphatase activity
FXN58_RS03830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FXN58_RS03835	COG2267	carboxylic ester hydrolase activity
FXN58_RS03840	COG3307	-O-antigen
FXN58_RS03845	COG0191	fructose-bisphosphate aldolase activity
FXN58_RS03855	COG3719	Belongs to the RNase T2 family
FXN58_RS03860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXN58_RS03865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FXN58_RS03870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXN58_RS03885	COG0463	Glycosyl transferase, family 2
FXN58_RS03890	COG1519	Transferase
FXN58_RS03905	COG0859	PFAM glycosyl transferase family 9
FXN58_RS03910	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXN58_RS03915	COG1917	Cupin 2, conserved barrel domain protein
FXN58_RS03915	COG4977	sequence-specific DNA binding
FXN58_RS03920	COG1132	(ABC) transporter
FXN58_RS03955	COG0758	DNA mediated transformation
FXN58_RS03960	COG0584	glycerophosphoryl diester phosphodiesterase
FXN58_RS03965	COG2271	Major facilitator Superfamily
FXN58_RS03975	COG0557	exoribonuclease II activity
FXN58_RS03980	COG1077	Cell shape determining protein MreB Mrl
FXN58_RS03985	COG1792	Involved in formation and maintenance of cell shape
FXN58_RS03990	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FXN58_RS04020	COG0006	proline dipeptidase activity
FXN58_RS04040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FXN58_RS04055	COG1496	oxidoreductase activity
FXN58_RS04065	COG0778	Nitroreductase
FXN58_RS04075	COG0762	integral membrane protein
FXN58_RS04095	COG0363	glucosamine-6-phosphate deaminase activity
FXN58_RS04100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FXN58_RS04105	COG1218	3'(2'),5'-bisphosphate nucleotidase
FXN58_RS04115	COG1297	OPT oligopeptide transporter protein
FXN58_RS04120	COG3293	Transposase
FXN58_RS04125	COG3059	membrane
FXN58_RS04130	COG4977	sequence-specific DNA binding
FXN58_RS04130	COG1917	Cupin 2, conserved barrel domain protein
FXN58_RS04135	COG0494	nUDIX hydrolase
FXN58_RS04140	COG1011	Hydrolase
FXN58_RS04145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FXN58_RS04150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FXN58_RS04155	COG3293	Transposase
FXN58_RS04175	COG3293	Transposase
FXN58_RS04185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXN58_RS04190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXN58_RS04195	COG0805	protein transport
FXN58_RS04220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FXN58_RS04230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FXN58_RS04240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FXN58_RS04260	COG0201	protein transport
FXN58_RS04280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FXN58_RS04295	COG0814	amino acid
FXN58_RS04305	COG3423	Transcriptional regulator
FXN58_RS04320	COG2129	metallophosphoesterase
FXN58_RS04325	COG3172	ATPase kinase involved in NAD metabolism
FXN58_RS04340	COG1739	Uncharacterized protein family UPF0029
FXN58_RS04350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FXN58_RS04355	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
FXN58_RS04400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FXN58_RS04405	COG0084	hydrolase, TatD family'
FXN58_RS04410	COG0602	queuosine metabolic process
FXN58_RS04415	COG1328	CTP reductase activity
FXN58_RS04415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXN58_RS04425	COG1022	Amp-dependent synthetase and ligase
FXN58_RS04430	COG0587	DNA-directed DNA polymerase activity
FXN58_RS04445	COG0753	catalase activity
FXN58_RS04450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FXN58_RS04455	COG0165	Argininosuccinate lyase
FXN58_RS04485	COG0582	viral genome integration into host DNA
FXN58_RS04520	COG1598	PFAM Uncharacterised protein family UPF0150
FXN58_RS04535	COG3617	BRO family, N-terminal domain
FXN58_RS04550	COG1869	D-ribose catabolic process
FXN58_RS04560	COG0730	response to heat
FXN58_RS04580	COG0590	tRNA wobble adenosine to inosine editing
FXN58_RS04610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FXN58_RS04615	COG4942	peptidase
FXN58_RS04620	COG2861	carbohydrate metabolic process
FXN58_RS04625	COG0606	chelatase, subunit chli
FXN58_RS04680	COG3293	Transposase
FXN58_RS04720	COG3501	Rhs element vgr protein
FXN58_RS04735	COG3293	Transposase
FXN58_RS04750	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FXN58_RS04780	COG2990	Protein conserved in bacteria
FXN58_RS04785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FXN58_RS04805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FXN58_RS04845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FXN58_RS04845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FXN58_RS04850	COG0569	domain protein
FXN58_RS04860	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FXN58_RS04875	COG2841	Protein conserved in bacteria
FXN58_RS04880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FXN58_RS04885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FXN58_RS04890	COG3036	rescue of stalled ribosome
FXN58_RS04900	COG1393	Belongs to the ArsC family
FXN58_RS04910	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FXN58_RS04915	COG1522	sequence-specific DNA binding
FXN58_RS04925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FXN58_RS04930	COG0038	chloride channel
FXN58_RS04935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FXN58_RS04940	COG0549	Belongs to the carbamate kinase family
FXN58_RS04945	COG1288	antiporter activity
FXN58_RS04955	COG0183	Belongs to the thiolase family
FXN58_RS04960	COG2031	fatty acid transporter
FXN58_RS04965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FXN58_RS04970	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FXN58_RS04975	COG3293	Transposase
FXN58_RS04985	COG0051	transcription antitermination factor activity, RNA binding
FXN58_RS04990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FXN58_RS04995	COG0088	Forms part of the polypeptide exit tunnel
FXN58_RS05000	COG0089	rRNA binding
FXN58_RS05005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FXN58_RS05010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FXN58_RS05015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FXN58_RS05020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FXN58_RS05025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FXN58_RS05030	COG0255	Belongs to the universal ribosomal protein uL29 family
FXN58_RS05035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FXN58_RS05050	COG2801	Transposase and inactivated derivatives
FXN58_RS05110	COG4964	Belongs to the GSP D family
FXN58_RS05140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FXN58_RS05150	COG1444	tRNA N-acetyltransferase activity
FXN58_RS05155	COG3293	Transposase
FXN58_RS05160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FXN58_RS05170	COG1126	abc transporter atp-binding protein
FXN58_RS05175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN58_RS05180	COG4215	(ABC) transporter
FXN58_RS05185	COG4160	amino acid transport
FXN58_RS05190	COG1966	Carbon starvation protein
FXN58_RS05205	COG3116	cell division
FXN58_RS05210	COG0768	penicillin binding
FXN58_RS05220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FXN58_RS05230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FXN58_RS05240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FXN58_RS05255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FXN58_RS05260	COG0849	cell division
FXN58_RS05265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FXN58_RS05275	COG0077	Prephenate dehydratase
FXN58_RS05275	COG1605	Chorismate mutase
FXN58_RS05280	COG0326	Molecular chaperone. Has ATPase activity
FXN58_RS05285	COG1393	Belongs to the ArsC family
FXN58_RS05295	COG1876	peptidase activity
FXN58_RS05300	COG0494	nUDIX hydrolase
FXN58_RS05305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FXN58_RS05350	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FXN58_RS05360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FXN58_RS05365	COG1053	succinate dehydrogenase
FXN58_RS05380	COG1120	ATPase activity
FXN58_RS05385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN58_RS05395	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FXN58_RS05410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FXN58_RS05415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FXN58_RS05445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXN58_RS05455	COG0741	lytic transglycosylase activity
FXN58_RS05460	COG2350	Protein conserved in bacteria
FXN58_RS05465	COG1607	acyl-coa hydrolase
FXN58_RS05480	COG3293	Transposase
FXN58_RS05485	COG3047	cAMP biosynthetic process
FXN58_RS05490	COG0497	DNA recombination
FXN58_RS05500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FXN58_RS05510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN58_RS05510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FXN58_RS05515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN58_RS05520	COG0784	Response regulator, receiver
FXN58_RS05520	COG5002	protein histidine kinase activity
FXN58_RS05520	COG2198	Histidine kinase
FXN58_RS05525	COG3293	Transposase
FXN58_RS05530	COG4211	Belongs to the binding-protein-dependent transport system permease family
FXN58_RS05535	COG1129	ABC transporter
FXN58_RS05540	COG1879	ABC-type sugar transport system periplasmic component
FXN58_RS05545	COG1609	Transcriptional regulator
FXN58_RS05550	COG1085	galactose-1-phosphate uridylyltransferase
FXN58_RS05555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FXN58_RS05560	COG2017	converts alpha-aldose to the beta-anomer
FXN58_RS05590	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
FXN58_RS05595	COG4535	Mg2 and Co2 transporter CorC
FXN58_RS05615	COG0105	UTP biosynthetic process
FXN58_RS05635	COG1388	LysM domain
FXN58_RS05635	COG4942	peptidase
FXN58_RS05645	COG1238	metal cluster binding
FXN58_RS05675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FXN58_RS05690	COG3293	Transposase
FXN58_RS05705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FXN58_RS05715	COG0733	neurotransmitter:sodium symporter activity
FXN58_RS05725	COG1285	pathogenesis
FXN58_RS05730	COG2801	Transposase and inactivated derivatives
FXN58_RS05770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXN58_RS05770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXN58_RS05770	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FXN58_RS05775	COG1105	Belongs to the carbohydrate kinase PfkB family
FXN58_RS05780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN58_RS05780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN58_RS05790	COG0746	molybdenum cofactor guanylyltransferase activity
FXN58_RS05795	COG3084	Protein conserved in bacteria
FXN58_RS05800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN58_RS05805	COG3085	chromosome segregation
FXN58_RS05860	COG0561	phosphatase activity
FXN58_RS05870	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FXN58_RS05880	COG2610	gluconate transmembrane transporter activity
FXN58_RS05890	COG0235	Class ii aldolase
FXN58_RS05895	COG3395	kinase activity
FXN58_RS05900	COG2084	Dehydrogenase
FXN58_RS05905	COG1349	DNA-binding transcription factor activity
FXN58_RS05910	COG0347	Belongs to the P(II) protein family
FXN58_RS05915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FXN58_RS05920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FXN58_RS05925	COG0470	DNA polymerase III
FXN58_RS05930	COG0084	hydrolase, TatD family'
FXN58_RS05940	COG1253	flavin adenine dinucleotide binding
FXN58_RS05945	COG3293	Transposase
FXN58_RS05970	COG0489	protein tyrosine kinase activity
FXN58_RS05975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXN58_RS05975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXN58_RS05980	COG2975	iron-sulfur cluster assembly
FXN58_RS05985	COG0633	Ferredoxin
FXN58_RS05990	COG0443	Heat shock 70 kDa protein
FXN58_RS06005	COG3293	Transposase
FXN58_RS06010	COG0822	iron-sulfur transferase activity
FXN58_RS06020	COG1959	2 iron, 2 sulfur cluster binding
FXN58_RS06025	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FXN58_RS06065	COG0626	cystathionine gamma-synthase activity
FXN58_RS06070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXN58_RS06090	COG1530	ribonuclease E activity
FXN58_RS06100	COG2259	Doxx family
FXN58_RS06105	COG3293	Transposase
FXN58_RS06115	COG1611	Belongs to the LOG family
FXN58_RS06125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FXN58_RS06130	COG0745	RESPONSE REGULATOR receiver
FXN58_RS06135	COG4608	Belongs to the ABC transporter superfamily
FXN58_RS06140	COG0444	Belongs to the ABC transporter superfamily
FXN58_RS06145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FXN58_RS06150	COG0601	transmembrane transport
FXN58_RS06155	COG4166	transmembrane transport
FXN58_RS06165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FXN58_RS06170	COG0697	spore germination
FXN58_RS06190	COG0142	geranyltranstransferase activity
FXN58_RS06195	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FXN58_RS06220	COG2056	Na+-H+ antiporter family
FXN58_RS06225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXN58_RS06230	COG0346	lactoylglutathione lyase activity
FXN58_RS06240	COG2271	Major facilitator Superfamily
FXN58_RS06255	COG1755	Isoprenylcysteine carboxyl methyltransferase
FXN58_RS06260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FXN58_RS06270	COG3293	Transposase
FXN58_RS06280	COG0494	nUDIX hydrolase
FXN58_RS06285	COG0217	transcriptional regulatory protein
FXN58_RS06315	COG1271	oxidase subunit
FXN58_RS06320	COG1294	oxidase, subunit
FXN58_RS06335	COG0824	Thioesterase
FXN58_RS06340	COG0811	peptide transport
FXN58_RS06345	COG0848	biopolymer transport protein
FXN58_RS06350	COG3064	Membrane
FXN58_RS06375	COG4795	General secretion pathway protein
FXN58_RS06390	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FXN58_RS06395	COG0456	acetyltransferase
FXN58_RS06400	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
FXN58_RS06405	COG2813	Specifically methylates the guanine in position
FXN58_RS06425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FXN58_RS06435	COG2994	toxin metabolic process
FXN58_RS06440	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FXN58_RS06445	COG2274	protein secretion by the type I secretion system
FXN58_RS06450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN58_RS06455	COG0673	inositol 2-dehydrogenase activity
FXN58_RS06465	COG3962	Belongs to the TPP enzyme family
FXN58_RS06470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXN58_RS06485	COG3293	Transposase
FXN58_RS06510	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FXN58_RS06535	COG3623	hexulose-6-phosphate isomerase
FXN58_RS06540	COG0235	Class ii aldolase
FXN58_RS06580	COG0814	amino acid
FXN58_RS06590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FXN58_RS06595	COG0778	Nitroreductase
FXN58_RS06610	COG2268	Band 7 protein
FXN58_RS06615	COG0114	fumarate hydratase activity
FXN58_RS06620	COG2927	DNA polymerase III (CHI subunit)
FXN58_RS06675	COG1566	PFAM secretion protein HlyD family protein
FXN58_RS06680	COG3293	Transposase
FXN58_RS06685	COG0783	Belongs to the Dps family
FXN58_RS06695	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FXN58_RS06700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FXN58_RS06705	COG0602	queuosine metabolic process
FXN58_RS06710	COG0720	synthase
FXN58_RS06750	COG0673	inositol 2-dehydrogenase activity
FXN58_RS06765	COG1129	ABC transporter
FXN58_RS06770	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXN58_RS06775	COG1454	alcohol dehydrogenase
FXN58_RS06775	COG1012	belongs to the aldehyde dehydrogenase family
FXN58_RS06780	COG3293	Transposase
FXN58_RS06790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FXN58_RS06795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FXN58_RS06800	COG1862	Preprotein translocase
FXN58_RS06810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FXN58_RS06820	COG0826	peptidase U32
FXN58_RS06835	COG2026	Addiction module toxin, RelE StbE family
FXN58_RS06855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXN58_RS06865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FXN58_RS06885	COG1620	l-lactate permease
FXN58_RS06900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FXN58_RS06905	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FXN58_RS06915	COG4991	sh3 domain protein
FXN58_RS06920	COG0306	phosphate transporter
FXN58_RS06925	COG1392	Phosphate transport regulator
FXN58_RS06930	COG3025	triphosphatase activity
FXN58_RS06935	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FXN58_RS06940	COG0563	adenylate kinase activity
FXN58_RS06945	COG2814	Major facilitator Superfamily
FXN58_RS06950	COG0375	protein maturation
FXN58_RS06955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FXN58_RS06960	COG3152	Membrane
FXN58_RS06965	COG2252	PERMEase
FXN58_RS06980	COG0825	malonyl-CoA metabolic process
FXN58_RS06985	COG2351	hydroxyisourate hydrolase activity
FXN58_RS07000	COG3041	Addiction module toxin RelE StbE family
FXN58_RS07005	COG3077	Addiction module antitoxin, RelB DinJ family
FXN58_RS07015	COG3069	C4-dicarboxylate transmembrane transporter activity
FXN58_RS07035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN58_RS07040	COG0785	Cytochrome C biogenesis protein
FXN58_RS07045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXN58_RS07045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXN58_RS07050	COG0288	reversible hydration of carbon dioxide
FXN58_RS07055	COG2823	Periplasmic or secreted lipoprotein
FXN58_RS07060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FXN58_RS07065	COG0792	nuclease activity
FXN58_RS07075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FXN58_RS07085	COG1252	NADH dehydrogenase
FXN58_RS07095	COG3293	Transposase
FXN58_RS07100	COG0616	signal peptide processing
FXN58_RS07105	COG3047	cAMP biosynthetic process
FXN58_RS07105	COG2885	chlorophyll binding
FXN58_RS07110	COG0625	glutathione transferase activity
FXN58_RS07115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FXN58_RS07125	COG0187	DNA topoisomerase II activity
FXN58_RS07130	COG3293	Transposase
FXN58_RS07140	COG0488	(ABC) transporter
FXN58_RS07145	COG3683	transport system, periplasmic component
FXN58_RS07150	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FXN58_RS07170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXN58_RS07175	COG3105	Protein conserved in bacteria
FXN58_RS07180	COG1944	ATP diphosphatase activity
FXN58_RS07190	COG3422	double-strand break repair
FXN58_RS07195	COG2190	(PTS) system
FXN58_RS07195	COG1263	PTS System
FXN58_RS07195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN58_RS07200	COG2226	methyltransferase
FXN58_RS07205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN58_RS07215	COG1846	Transcriptional regulator
FXN58_RS07215	COG1940	carbohydrate kinase activity
FXN58_RS07250	COG3293	Transposase
FXN58_RS07310	COG3293	Transposase
FXN58_RS07315	COG3008	intermembrane lipid transfer
FXN58_RS07320	COG2995	paraquat-inducible protein a
FXN58_RS07330	COG0793	Belongs to the peptidase S41A family
FXN58_RS07335	COG2989	Protein conserved in bacteria
FXN58_RS07340	COG3108	Peptidase M15
FXN58_RS07345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN58_RS07350	COG0567	Dehydrogenase, E1 component
FXN58_RS07355	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXN58_RS07365	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FXN58_RS07400	COG3293	Transposase
FXN58_RS07425	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FXN58_RS07435	COG3260	NADH ubiquinone oxidoreductase 20
FXN58_RS07445	COG3261	NADH dehydrogenase
FXN58_RS07445	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
FXN58_RS07450	COG0651	ATP synthesis coupled electron transport
FXN58_RS07455	COG4237	Hydrogenase 4 membrane
FXN58_RS07460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FXN58_RS07465	COG0650	Formate hydrogenlyase subunit 4
FXN58_RS07470	COG0651	ATP synthesis coupled electron transport
FXN58_RS07475	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXN58_RS07485	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FXN58_RS07490	COG2864	formate dehydrogenase
FXN58_RS07495	COG0437	4 iron, 4 sulfur cluster binding
FXN58_RS07515	COG1609	Transcriptional regulator
FXN58_RS07520	COG3265	gluconokinase activity
FXN58_RS07525	COG2610	gluconate transmembrane transporter activity
FXN58_RS07530	COG0210	DNA helicase
FXN58_RS07535	COG1793	dna ligase
FXN58_RS07540	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FXN58_RS07545	COG4115	mRNA cleavage
FXN58_RS07550	COG2161	toxin-antitoxin pair type II binding
FXN58_RS07555	COG5039	Polysaccharide pyruvyl transferase
FXN58_RS07565	COG3293	Transposase
FXN58_RS07570	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN58_RS07580	COG1216	Glycosyl transferase, family 2
FXN58_RS07585	COG1216	Glycosyl transferase, family 2
FXN58_RS07590	COG2951	lytic endotransglycosylase activity
FXN58_RS07595	COG0708	Exodeoxyribonuclease III
FXN58_RS07600	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FXN58_RS07610	COG3293	Transposase
FXN58_RS07625	COG0671	phosphoesterase, PA-phosphatase related
FXN58_RS07645	COG0515	serine threonine protein kinase
FXN58_RS07650	COG1946	Acyl-CoA thioesterase
FXN58_RS07660	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FXN58_RS07665	COG4988	ABC transporter
FXN58_RS07670	COG0492	ferredoxin-NADP+ reductase activity
FXN58_RS07675	COG3118	belongs to the thioredoxin family
FXN58_RS07685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FXN58_RS07690	COG0303	'Molybdopterin
FXN58_RS07700	COG2027	D-alanyl-D-alanine carboxypeptidase
FXN58_RS07705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXN58_RS07710	COG1534	Rna-binding protein
FXN58_RS07715	COG3657	addiction module killer protein
FXN58_RS07720	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXN58_RS07725	COG0307	riboflavin synthase, alpha
FXN58_RS07735	COG4774	siderophore transport
FXN58_RS07740	COG4178	(ABC) transporter
FXN58_RS07745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FXN58_RS07750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FXN58_RS07760	COG3102	Protein conserved in bacteria
FXN58_RS07765	COG3133	Outer membrane lipoprotein
FXN58_RS07770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FXN58_RS07775	COG2890	protein-(glutamine-N5) methyltransferase activity
FXN58_RS07785	COG3293	Transposase
FXN58_RS07790	COG0791	NLP P60 protein
FXN58_RS07800	COG3100	YcgL domain-containing protein
FXN58_RS07815	COG2062	phosphohistidine phosphatase, SixA
FXN58_RS07825	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FXN58_RS07830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FXN58_RS07840	COG2932	Transcriptional regulator
FXN58_RS07850	COG0517	IMP dehydrogenase activity
FXN58_RS07850	COG0516	GMP reductase activity
FXN58_RS07890	COG4172	Belongs to the ABC transporter superfamily
FXN58_RS07895	COG4172	Belongs to the ABC transporter superfamily
FXN58_RS07900	COG4171	peptide transport system, permease
FXN58_RS07905	COG4168	peptide transport system, permease
FXN58_RS07910	COG4166	transmembrane transport
FXN58_RS07915	COG3106	COG3106 Predicted ATPase
FXN58_RS07925	COG3283	Transcriptional regulator of aromatic amino acids metabolism
FXN58_RS07940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FXN58_RS07945	COG0860	N-Acetylmuramoyl-L-alanine amidase
FXN58_RS07945	COG1388	LysM domain
FXN58_RS07950	COG0802	atpase or kinase
FXN58_RS07960	COG2246	polysaccharide biosynthetic process
FXN58_RS07970	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FXN58_RS07980	COG2194	sulfuric ester hydrolase activity
FXN58_RS08000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN58_RS08005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FXN58_RS08010	COG2190	(PTS) system
FXN58_RS08015	COG0339	signal peptide processing
FXN58_RS08020	COG2832	Protein of unknown function (DUF454)
FXN58_RS08025	COG4166	transmembrane transport
FXN58_RS08055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FXN58_RS08065	COG0512	Glutamine amidotransferase of anthranilate synthase
FXN58_RS08070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXN58_RS08115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FXN58_RS08120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FXN58_RS08130	COG3684	Belongs to the aldolase LacD family
FXN58_RS08140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN58_RS08145	COG3414	Phosphotransferase system galactitol-specific IIB component
FXN58_RS08150	COG3775	system Galactitol-specific IIC component
FXN58_RS08155	COG1063	alcohol dehydrogenase
FXN58_RS08160	COG1349	DNA-binding transcription factor activity
FXN58_RS08170	COG0142	geranyltranstransferase activity
FXN58_RS08185	COG0285	dihydrofolate synthase activity
FXN58_RS08190	COG0406	alpha-ribazole phosphatase activity
FXN58_RS08200	COG2431	L-lysine efflux transmembrane transporter activity
FXN58_RS08205	COG0564	pseudouridine synthase activity
FXN58_RS08215	COG2824	Alkylphosphonate utilization operon protein PhnA
FXN58_RS08225	COG1538	Outer membrane efflux protein
FXN58_RS08230	COG1136	(ABC) transporter
FXN58_RS08230	COG0577	efflux transmembrane transporter activity
FXN58_RS08235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN58_RS08280	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXN58_RS08285	COG1136	(ABC) transporter
FXN58_RS08290	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXN58_RS08295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FXN58_RS08300	COG0305	Participates in initiation and elongation during chromosome replication
FXN58_RS08310	COG0166	Belongs to the GPI family
FXN58_RS08325	COG3293	Transposase
FXN58_RS08330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FXN58_RS08340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FXN58_RS08345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FXN58_RS08350	COG1280	lysine exporter protein (LysE YggA)
FXN58_RS08365	COG0633	Ferredoxin
FXN58_RS08375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN58_RS08385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN58_RS08420	COG3293	Transposase
FXN58_RS08425	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN58_RS08435	COG3842	ATPase activity
FXN58_RS08440	COG0366	Alpha amylase catalytic
FXN58_RS08445	COG3833	ABC-type maltose transport systems, permease component
FXN58_RS08455	COG2182	Extracellular solute-binding protein
FXN58_RS08460	COG3842	ATPase activity
FXN58_RS08465	COG4580	involved in the transport of maltose and maltodextrins
FXN58_RS08480	COG1199	ATP-dependent helicase activity
FXN58_RS08485	COG1214	PFAM Peptidase M22, glycoprotease
FXN58_RS08490	COG3065	identical protein binding
FXN58_RS08495	COG0318	PFAM AMP-dependent synthetase and ligase
FXN58_RS08500	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FXN58_RS08505	COG1858	cytochrome C peroxidase
FXN58_RS08530	COG0330	HflC and HflK could
FXN58_RS08540	COG2249	NAD(P)H dehydrogenase (quinone) activity
FXN58_RS08545	COG3381	protein complex oligomerization
FXN58_RS08550	COG1560	Kdo2-lipid A biosynthetic process
FXN58_RS08555	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FXN58_RS08555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FXN58_RS08560	COG2166	iron-sulfur cluster assembly
FXN58_RS08565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FXN58_RS08570	COG1525	nuclease
FXN58_RS08585	COG4774	siderophore transport
FXN58_RS08595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FXN58_RS08600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN58_RS08610	COG3585	molybdate ion transport
FXN58_RS08620	COG1120	ATPase activity
FXN58_RS08635	COG3293	Transposase
FXN58_RS08645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FXN58_RS08655	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FXN58_RS08660	COG0314	molybdopterin synthase activity
FXN58_RS08670	COG2969	positive regulation of protein catabolic process
FXN58_RS08680	COG1940	carbohydrate kinase activity
FXN58_RS08685	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FXN58_RS08710	COG2390	Transcriptional regulator
FXN58_RS08715	COG3293	Transposase
FXN58_RS08735	COG1879	ABC-type sugar transport system periplasmic component
FXN58_RS08745	COG3293	Transposase
FXN58_RS08755	COG0469	pyruvate kinase activity
FXN58_RS08765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN58_RS08775	COG0133	tryptophan synthase activity
FXN58_RS08780	COG4221	oxidoreductase activity
FXN58_RS08815	COG3630	sodium ion export across plasma membrane
FXN58_RS08820	COG3293	Transposase
FXN58_RS08835	COG0298	carbon dioxide binding
FXN58_RS08845	COG0135	phosphoribosylanthranilate isomerase activity
FXN58_RS08845	COG0134	indole-3-glycerol-phosphate synthase activity
FXN58_RS08855	COG1942	4-Oxalocrotonate Tautomerase
FXN58_RS08860	COG0512	Glutamine amidotransferase of anthranilate synthase
FXN58_RS08865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FXN58_RS08875	COG0517	IMP dehydrogenase activity
FXN58_RS08875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FXN58_RS08890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FXN58_RS08905	COG0791	NLP P60 protein
FXN58_RS08920	COG0842	Transport permease protein
FXN58_RS08940	COG3293	Transposase
FXN58_RS08950	COG1448	Aminotransferase
FXN58_RS08955	COG0308	aminopeptidase N
FXN58_RS08960	COG0167	dihydroorotate dehydrogenase activity
FXN58_RS08965	COG0613	PHP domain protein
FXN58_RS08985	COG0589	response to stress
FXN58_RS08990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FXN58_RS08995	COG1528	Iron-storage protein
FXN58_RS09000	COG1528	Iron-storage protein
FXN58_RS09025	COG2925	Exonuclease
FXN58_RS09030	COG0697	spore germination
FXN58_RS09035	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FXN58_RS09040	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FXN58_RS09050	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FXN58_RS09055	COG1686	Belongs to the peptidase S11 family
FXN58_RS09065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FXN58_RS09070	COG0586	Pfam SNARE associated Golgi protein
FXN58_RS09090	COG3293	Transposase
FXN58_RS09100	COG3657	addiction module killer protein
FXN58_RS09115	COG1346	cytolysis
FXN58_RS09125	COG3293	Transposase
FXN58_RS09150	COG3293	Transposase
FXN58_RS09170	COG3005	denitrification pathway
FXN58_RS09175	COG0243	molybdopterin cofactor binding
FXN58_RS09180	COG2315	Protein conserved in bacteria
FXN58_RS09185	COG0471	metal ion transport
FXN58_RS09195	COG2026	Addiction module toxin, RelE StbE family
FXN58_RS09200	COG0101	tRNA pseudouridine synthase activity
FXN58_RS09220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXN58_RS09225	COG1074	ATP-dependent DNA helicase activity
FXN58_RS09230	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FXN58_RS09240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FXN58_RS09245	COG1067	ATP-dependent peptidase activity
FXN58_RS09255	COG1278	Cold shock
FXN58_RS09270	COG3098	single-species biofilm formation
FXN58_RS09275	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FXN58_RS09290	COG3293	Transposase
FXN58_RS09315	COG1178	ABC-type Fe3 transport system permease component
FXN58_RS09320	COG3842	ATPase activity
FXN58_RS09325	COG3101	peptidyl-lysine hydroxylation
FXN58_RS09330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FXN58_RS09340	COG0788	formyltetrahydrofolate deformylase activity
FXN58_RS09345	COG2916	Histone family protein nucleoid-structuring protein H-NS
FXN58_RS09350	COG1757	Na H antiporter
FXN58_RS09355	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FXN58_RS09365	COG0251	oxidation-reduction process
FXN58_RS09380	COG0463	Glycosyl transferase, family 2
FXN58_RS09390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FXN58_RS09400	COG1560	Kdo2-lipid A biosynthetic process
FXN58_RS09405	COG0730	response to heat
FXN58_RS09410	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FXN58_RS09415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FXN58_RS09420	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FXN58_RS09420	COG3264	Mechanosensitive ion channel
FXN58_RS09425	COG0318	PFAM AMP-dependent synthetase and ligase
FXN58_RS09430	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FXN58_RS09435	COG0596	Alpha beta hydrolase
FXN58_RS09445	COG0716	FMN binding
FXN58_RS09450	COG0735	belongs to the Fur family
FXN58_RS09455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FXN58_RS09460	COG3094	Invasion gene expression up-regulator, SirB
FXN58_RS09465	COG0023	Translation Initiation Factor
FXN58_RS09475	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FXN58_RS09480	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FXN58_RS09485	COG0776	regulation of translation
FXN58_RS09490	COG0539	negative regulation of cytoplasmic translation
FXN58_RS09500	COG2990	Protein conserved in bacteria
FXN58_RS09510	COG0612	Peptidase, M16
FXN58_RS09515	COG1687	branched-chain amino acid
FXN58_RS09520	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FXN58_RS09525	COG0583	DNA-binding transcription factor activity
FXN58_RS09535	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FXN58_RS09580	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FXN58_RS09585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN58_RS09600	COG3293	Transposase
FXN58_RS09605	COG0405	Gamma-glutamyltransferase
FXN58_RS09610	COG0642	Histidine kinase
FXN58_RS09615	COG0745	RESPONSE REGULATOR receiver
FXN58_RS09620	COG3111	PFAM Bacterial OB fold (BOF) protein
FXN58_RS09635	COG0737	Belongs to the 5'-nucleotidase family
FXN58_RS09640	COG4607	ABC-type enterochelin transport system periplasmic component
FXN58_RS09645	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN58_RS09650	COG4605	iron ion homeostasis
FXN58_RS09655	COG4604	ABC transporter, ATP-binding protein
FXN58_RS09660	COG0739	heme binding
FXN58_RS09670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN58_RS09675	COG0733	neurotransmitter:sodium symporter activity
FXN58_RS09680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FXN58_RS09700	COG4656	Part of a membrane complex involved in electron transport
FXN58_RS09710	COG4657	Part of a membrane complex involved in electron transport
FXN58_RS09715	COG1090	epimerase
FXN58_RS09720	COG1438	arginine binding
FXN58_RS09725	COG0039	L-malate dehydrogenase activity
FXN58_RS09740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FXN58_RS09745	COG0583	DNA-binding transcription factor activity
FXN58_RS09755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXN58_RS09760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXN58_RS09760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXN58_RS09765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXN58_RS09775	COG0471	metal ion transport
FXN58_RS09780	COG2005	Transcriptional regulator
FXN58_RS09785	COG0725	ABC transporter, periplasmic molybdate-binding protein
FXN58_RS09790	COG4149	molybdate abc transporter
FXN58_RS09805	COG0795	lipopolysaccharide-transporting ATPase activity
FXN58_RS09810	COG0795	lipopolysaccharide-transporting ATPase activity
FXN58_RS09815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FXN58_RS09820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXN58_RS09845	COG3293	Transposase
FXN58_RS09855	COG0309	Hydrogenase expression formation protein (HypE)
FXN58_RS09865	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FXN58_RS09870	COG1122	ATPase activity
FXN58_RS09875	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FXN58_RS09880	COG0310	cobalt ion transport
FXN58_RS09885	COG0310	cobalt ion transport
FXN58_RS09890	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
FXN58_RS09895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FXN58_RS09900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN58_RS09905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FXN58_RS09910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN58_RS09925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FXN58_RS09940	COG2949	membrane
FXN58_RS09945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXN58_RS09965	COG0583	DNA-binding transcription factor activity
FXN58_RS09975	COG0009	L-threonylcarbamoyladenylate synthase
FXN58_RS09980	COG1605	Chorismate mutase
FXN58_RS09980	COG0287	Prephenate dehydrogenase
FXN58_RS09985	COG0616	signal peptide processing
FXN58_RS09990	COG0778	Nitroreductase
FXN58_RS09995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXN58_RS10000	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXN58_RS10005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FXN58_RS10020	COG0058	SHG alpha-glucan phosphorylase activity
FXN58_RS10025	COG1640	4-alpha-glucanotransferase
FXN58_RS10030	COG1286	toxin biosynthetic process
FXN58_RS10035	COG3092	negative regulation of chromosome organization
FXN58_RS10040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FXN58_RS10045	COG0857	belongs to the CobB CobQ family
FXN58_RS10045	COG0280	phosphate acetyltransferase
FXN58_RS10055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FXN58_RS10060	COG0617	tRNA 3'-terminal CCA addition
FXN58_RS10070	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FXN58_RS10075	COG3293	Transposase
FXN58_RS10090	COG1663	tetraacyldisaccharide 4'-kinase activity
FXN58_RS10095	COG2835	tetraacyldisaccharide 4'-kinase activity
FXN58_RS10105	COG0322	excinuclease ABC activity
FXN58_RS10115	COG0395	ABC-type sugar transport system, permease component
FXN58_RS10125	COG3842	ATPase activity
FXN58_RS10140	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FXN58_RS10145	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FXN58_RS10150	COG3293	Transposase
FXN58_RS10175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FXN58_RS10195	COG0195	Participates in both transcription termination and antitermination
FXN58_RS10280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FXN58_RS10285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FXN58_RS10295	COG0024	Methionine aminopeptidase
FXN58_RS10300	COG0316	Belongs to the HesB IscA family
FXN58_RS10310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXN58_RS10315	COG0672	)-iron permease
FXN58_RS10330	COG1136	(ABC) transporter
FXN58_RS10330	COG0577	efflux transmembrane transporter activity
FXN58_RS10340	COG1136	(ABC) transporter
FXN58_RS10340	COG0577	efflux transmembrane transporter activity
FXN58_RS10345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN58_RS10355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FXN58_RS10375	COG1643	Atp-dependent helicase
FXN58_RS10380	COG2363	Small membrane protein
FXN58_RS10400	COG3293	Transposase
FXN58_RS10405	COG0277	FAD linked oxidase domain protein
FXN58_RS10405	COG0247	lactate metabolic process
FXN58_RS10420	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FXN58_RS10425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FXN58_RS10430	COG0363	glucosamine-6-phosphate deaminase activity
FXN58_RS10435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXN58_RS10440	COG1737	Transcriptional regulator
FXN58_RS10450	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FXN58_RS10455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FXN58_RS10470	COG1263	PTS System
FXN58_RS10470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN58_RS10470	COG2190	(PTS) system
FXN58_RS10510	COG3842	ATPase activity
FXN58_RS10515	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN58_RS10520	COG1177	transmembrane transport
FXN58_RS10525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN58_RS10540	COG3293	Transposase
FXN58_RS10550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FXN58_RS10565	COG1522	sequence-specific DNA binding
FXN58_RS10575	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FXN58_RS10580	COG1178	ABC-type Fe3 transport system permease component
FXN58_RS10585	COG4143	(ABC) transporter
FXN58_RS10630	COG2920	part of a sulfur-relay system
FXN58_RS10640	COG1121	(ABC) transporter
FXN58_RS10645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN58_RS10650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN58_RS10670	COG3304	Inner membrane component domain
FXN58_RS10675	COG1289	transmembrane transporter activity
FXN58_RS10690	COG3958	Transketolase
FXN58_RS10695	COG3959	Transketolase, thiamine diphosphate binding domain
FXN58_RS10760	COG3293	Transposase
FXN58_RS10765	COG4953	penicillin-binding protein 1C
FXN58_RS10770	COG3293	Transposase
FXN58_RS10775	COG2855	membrane
FXN58_RS10790	COG0157	Belongs to the NadC ModD family
FXN58_RS10795	COG3842	ATPase activity
FXN58_RS10800	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FXN58_RS10805	COG0725	ABC transporter, periplasmic molybdate-binding protein
FXN58_RS10815	COG5339	Protein conserved in bacteria
FXN58_RS10820	COG0443	Heat shock 70 kDa protein
FXN58_RS10825	COG0484	heat shock protein binding
FXN58_RS10830	COG2337	Toxic component of a toxin-antitoxin (TA) module
FXN58_RS10845	COG0626	cystathionine gamma-synthase activity
FXN58_RS10850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FXN58_RS10925	COG0629	single-stranded DNA binding
FXN58_RS10970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FXN58_RS11210	COG2337	Toxic component of a toxin-antitoxin (TA) module
FXN58_RS11255	COG3021	interspecies interaction between organisms
FXN58_RS11285	COG3293	Transposase
FXN58_RS11295	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FXN58_RS11315	COG2999	glutathione oxidoreductase activity
FXN58_RS11320	COG1530	ribonuclease E activity
FXN58_RS11325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXN58_RS11350	COG3293	Transposase
FXN58_RS11360	COG3293	Transposase
FXN58_RS11385	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN58_RS11390	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN58_RS11415	COG3293	Transposase
FXN58_RS11440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FXN58_RS11450	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FXN58_RS11455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FXN58_RS11460	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FXN58_RS11465	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FXN58_RS11490	COG2850	peptidyl-arginine hydroxylation
FXN58_RS11505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN58_RS11510	COG1137	ATPase activity
FXN58_RS11515	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FXN58_RS11520	COG3117	lipopolysaccharide transmembrane transporter activity
FXN58_RS11525	COG1127	ABC transporter
FXN58_RS11530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FXN58_RS11535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FXN58_RS11540	COG2854	intermembrane phospholipid transfer
FXN58_RS11545	COG3113	response to antibiotic
FXN58_RS11550	COG5007	Belongs to the BolA IbaG family
FXN58_RS11570	COG3293	Transposase
FXN58_RS11575	COG3691	Protein conserved in bacteria
FXN58_RS11585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FXN58_RS11595	COG0861	Integral membrane protein TerC family
FXN58_RS11605	COG1217	gtp-binding protein TYPA
FXN58_RS11620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FXN58_RS11625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXN58_RS11645	COG1125	glycine betaine transport
FXN58_RS11645	COG0517	IMP dehydrogenase activity
FXN58_RS11650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FXN58_RS11660	COG0460	homoserine dehydrogenase
FXN58_RS11660	COG0527	aspartate kinase activity
FXN58_RS11675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FXN58_RS11680	COG2091	lysine biosynthetic process via aminoadipic acid
FXN58_RS11685	COG0330	HflC and HflK could
FXN58_RS11690	COG0330	HflC and HflK could
FXN58_RS11705	COG4974	Belongs to the 'phage' integrase family
FXN58_RS11710	COG2814	Major facilitator Superfamily
FXN58_RS11715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FXN58_RS11730	COG3061	Opacity-associated protein A
FXN58_RS11730	COG3266	domain, Protein
FXN58_RS11735	COG1509	lysine 2,3-aminomutase activity
FXN58_RS11745	COG3293	Transposase
FXN58_RS11755	COG3033	Beta-eliminating lyase
FXN58_RS11765	COG2964	Protein conserved in bacteria
FXN58_RS11770	COG5413	integral membrane protein
FXN58_RS11785	COG0204	Acyl-transferase
FXN58_RS11795	COG0697	spore germination
FXN58_RS11800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FXN58_RS11805	COG1882	Formate acetyltransferase
FXN58_RS11810	COG2116	formate transmembrane transporter activity
FXN58_RS11815	COG3293	Transposase
FXN58_RS11820	COG0537	adenosine 5'-monophosphoramidase activity
FXN58_RS11855	COG3022	response to hydroperoxide
FXN58_RS11860	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FXN58_RS11875	COG0681	Belongs to the peptidase S26 family