locus-tag	class	description
FXN59_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXN59_RS00010	COG0592	DNA-directed DNA polymerase activity
FXN59_RS00020	COG2226	methyltransferase
FXN59_RS00035	COG0281	malic enzyme
FXN59_RS00040	COG2081	HI0933 family
FXN59_RS00045	COG4235	cytochrome complex assembly
FXN59_RS00045	COG3088	subunit of a heme lyase
FXN59_RS00050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN59_RS00055	COG1138	Cytochrome C-type biogenesis protein
FXN59_RS00100	COG1138	Cytochrome C-type biogenesis protein
FXN59_RS00110	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN59_RS00115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN59_RS00120	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN59_RS00125	COG4133	protoheme IX ABC transporter activity
FXN59_RS00130	COG2814	Major facilitator Superfamily
FXN59_RS00165	COG2801	Transposase and inactivated derivatives
FXN59_RS00180	COG2267	carboxylic ester hydrolase activity
FXN59_RS00185	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FXN59_RS00195	COG0436	Aminotransferase
FXN59_RS00210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FXN59_RS00215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FXN59_RS00220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FXN59_RS00230	COG1652	LysM domain
FXN59_RS00235	COG2321	neutral zinc metallopeptidase
FXN59_RS00250	COG0280	phosphate acetyltransferase
FXN59_RS00250	COG0281	malic enzyme
FXN59_RS00280	COG2801	Transposase and inactivated derivatives
FXN59_RS00285	COG3091	SprT-like family
FXN59_RS00290	COG0814	amino acid
FXN59_RS00295	COG1760	l-serine dehydratase
FXN59_RS00300	COG0252	asparaginase activity
FXN59_RS00315	COG1426	Protein conserved in bacteria
FXN59_RS00330	COG2976	Protein conserved in bacteria
FXN59_RS00340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXN59_RS00345	COG2233	PERMEase
FXN59_RS00350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FXN59_RS00355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXN59_RS00360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FXN59_RS00370	COG0659	secondary active sulfate transmembrane transporter activity
FXN59_RS00390	COG2186	Transcriptional regulator
FXN59_RS00405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FXN59_RS00415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXN59_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
FXN59_RS00430	COG0800	Aldolase
FXN59_RS00445	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FXN59_RS00450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FXN59_RS00460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FXN59_RS00465	COG1555	photosystem II stabilization
FXN59_RS00475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FXN59_RS00495	COG0196	riboflavin kinase activity
FXN59_RS00500	COG0728	peptidoglycan biosynthetic process
FXN59_RS00515	COG0560	Phosphoserine phosphatase
FXN59_RS00525	COG0193	aminoacyl-tRNA hydrolase activity
FXN59_RS00530	COG0012	GTP binding
FXN59_RS00540	COG1573	uracil-dna glycosylase
FXN59_RS00545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FXN59_RS00555	COG3115	cell septum assembly
FXN59_RS00575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FXN59_RS00580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FXN59_RS00620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FXN59_RS00625	COG0255	Belongs to the universal ribosomal protein uL29 family
FXN59_RS00630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FXN59_RS00635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FXN59_RS00640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FXN59_RS00645	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FXN59_RS00650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FXN59_RS00655	COG0089	rRNA binding
FXN59_RS00660	COG0088	Forms part of the polypeptide exit tunnel
FXN59_RS00665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FXN59_RS00670	COG0051	transcription antitermination factor activity, RNA binding
FXN59_RS00675	COG0583	DNA-binding transcription factor activity
FXN59_RS00680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FXN59_RS00695	COG0183	Belongs to the thiolase family
FXN59_RS00705	COG1288	antiporter activity
FXN59_RS00710	COG0549	Belongs to the carbamate kinase family
FXN59_RS00715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FXN59_RS00720	COG0038	chloride channel
FXN59_RS00725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FXN59_RS00735	COG1522	sequence-specific DNA binding
FXN59_RS00740	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FXN59_RS00750	COG1393	Belongs to the ArsC family
FXN59_RS00760	COG3036	rescue of stalled ribosome
FXN59_RS00765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FXN59_RS00770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FXN59_RS00775	COG2841	Protein conserved in bacteria
FXN59_RS00790	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FXN59_RS00800	COG0569	domain protein
FXN59_RS00805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FXN59_RS00805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FXN59_RS00840	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
FXN59_RS00845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FXN59_RS00855	COG1739	Uncharacterized protein family UPF0029
FXN59_RS00870	COG3172	ATPase kinase involved in NAD metabolism
FXN59_RS00875	COG2129	metallophosphoesterase
FXN59_RS00880	COG0814	amino acid
FXN59_RS00895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FXN59_RS00915	COG0201	protein transport
FXN59_RS00935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FXN59_RS00945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FXN59_RS00955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FXN59_RS00980	COG0805	protein transport
FXN59_RS00985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXN59_RS00990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXN59_RS01000	COG3293	Transposase
FXN59_RS01020	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FXN59_RS01025	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FXN59_RS01030	COG1011	Hydrolase
FXN59_RS01035	COG0494	nUDIX hydrolase
FXN59_RS01040	COG4977	sequence-specific DNA binding
FXN59_RS01040	COG1917	Cupin 2, conserved barrel domain protein
FXN59_RS01045	COG3059	membrane
FXN59_RS01050	COG1297	OPT oligopeptide transporter protein
FXN59_RS01060	COG1218	3'(2'),5'-bisphosphate nucleotidase
FXN59_RS01065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FXN59_RS01070	COG0363	glucosamine-6-phosphate deaminase activity
FXN59_RS01090	COG0762	integral membrane protein
FXN59_RS01100	COG0778	Nitroreductase
FXN59_RS01105	COG1368	sulfuric ester hydrolase activity
FXN59_RS01110	COG1496	oxidoreductase activity
FXN59_RS01125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FXN59_RS01145	COG0006	proline dipeptidase activity
FXN59_RS01175	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FXN59_RS01180	COG1792	Involved in formation and maintenance of cell shape
FXN59_RS01185	COG1077	Cell shape determining protein MreB Mrl
FXN59_RS01190	COG0557	exoribonuclease II activity
FXN59_RS01200	COG2271	Major facilitator Superfamily
FXN59_RS01205	COG0584	glycerophosphoryl diester phosphodiesterase
FXN59_RS01210	COG0758	DNA mediated transformation
FXN59_RS01245	COG1132	(ABC) transporter
FXN59_RS01250	COG4977	sequence-specific DNA binding
FXN59_RS01250	COG1917	Cupin 2, conserved barrel domain protein
FXN59_RS01255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXN59_RS01260	COG0859	PFAM glycosyl transferase family 9
FXN59_RS01275	COG1519	Transferase
FXN59_RS01280	COG0463	Glycosyl transferase, family 2
FXN59_RS01295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXN59_RS01300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FXN59_RS01305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXN59_RS01310	COG3719	Belongs to the RNase T2 family
FXN59_RS01320	COG0191	fructose-bisphosphate aldolase activity
FXN59_RS01325	COG3307	-O-antigen
FXN59_RS01330	COG2267	carboxylic ester hydrolase activity
FXN59_RS01340	COG0561	phosphatase activity
FXN59_RS01345	COG3293	Transposase
FXN59_RS01360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FXN59_RS01375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FXN59_RS01390	COG0583	DNA-binding transcription factor activity
FXN59_RS01395	COG2962	Rard protein
FXN59_RS01410	COG0551	DNA topoisomerase type I activity
FXN59_RS01435	COG0705	Rhomboid family
FXN59_RS01440	COG1349	DNA-binding transcription factor activity
FXN59_RS01455	COG4178	(ABC) transporter
FXN59_RS01470	COG0233	cytoplasmic translational termination
FXN59_RS01475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FXN59_RS01485	COG0575	Belongs to the CDS family
FXN59_RS01500	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FXN59_RS01520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXN59_RS01530	COG0471	metal ion transport
FXN59_RS01530	COG0490	domain, Protein
FXN59_RS01535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FXN59_RS01545	COG4589	Belongs to the CDS family
FXN59_RS01550	COG0521	Mo-molybdopterin cofactor biosynthetic process
FXN59_RS01565	COG3276	selenocysteine insertion sequence binding
FXN59_RS01570	COG1921	L-seryl-tRNASec selenium transferase activity
FXN59_RS01575	COG0442	prolyl-tRNA aminoacylation
FXN59_RS01590	COG1595	DNA-templated transcription, initiation
FXN59_RS01595	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FXN59_RS01600	COG3026	antisigma factor binding
FXN59_RS01605	COG3086	response to oxidative stress
FXN59_RS01610	COG1763	Mo-molybdopterin cofactor biosynthetic process
FXN59_RS01615	COG0300	oxidoreductase activity
FXN59_RS01620	COG2195	Cleaves the N-terminal amino acid of tripeptides
FXN59_RS01630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FXN59_RS01635	COG2818	Glycosylase
FXN59_RS01640	COG3293	Transposase
FXN59_RS01645	COG3477	response to acidic pH
FXN59_RS01650	COG0019	diaminopimelate decarboxylase activity
FXN59_RS01665	COG0514	ATP-dependent DNA helicase (RecQ)
FXN59_RS01670	COG0187	DNA topoisomerase II activity
FXN59_RS01675	COG1072	(Pantothenic acid kinase))
FXN59_RS01700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FXN59_RS01705	COG1879	ABC-type sugar transport system periplasmic component
FXN59_RS01710	COG1129	ABC transporter
FXN59_RS01725	COG2183	response to ionizing radiation
FXN59_RS01730	COG0583	DNA-binding transcription factor activity
FXN59_RS01745	COG2183	response to ionizing radiation
FXN59_RS01750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXN59_RS01760	COG1595	DNA-templated transcription, initiation
FXN59_RS01770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FXN59_RS01775	COG3071	HemY protein
FXN59_RS01780	COG2959	enzyme of heme biosynthesis
FXN59_RS01790	COG0181	hydroxymethylbilane synthase activity
FXN59_RS01800	COG2197	response regulator
FXN59_RS01805	COG0729	surface antigen
FXN59_RS01810	COG2911	Protein conserved in bacteria
FXN59_RS01815	COG0248	Ppx GppA phosphatase
FXN59_RS01835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FXN59_RS01840	COG3068	Protein conserved in bacteria
FXN59_RS01850	COG1349	DNA-binding transcription factor activity
FXN59_RS01855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FXN59_RS01865	COG0433	COG0433 Predicted ATPase
FXN59_RS01870	COG2258	MOSC domain
FXN59_RS01875	COG3012	SEC-C Motif Domain Protein
FXN59_RS01890	COG0786	glutamate:sodium symporter activity
FXN59_RS01895	COG2205	protein histidine kinase activity
FXN59_RS01900	COG0745	RESPONSE REGULATOR receiver
FXN59_RS01905	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FXN59_RS01915	COG3082	Protein of unknown function (DUF1414)
FXN59_RS01920	COG3083	sulfuric ester hydrolase activity
FXN59_RS01925	COG0402	S-adenosylhomocysteine deaminase activity
FXN59_RS01930	COG3956	TIGRFAM MazG family protein
FXN59_RS01945	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FXN59_RS01955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FXN59_RS01960	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
FXN59_RS01965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FXN59_RS01980	COG0148	phosphopyruvate hydratase activity
FXN59_RS01995	COG2991	Protein conserved in bacteria
FXN59_RS02000	COG1477	protein flavinylation
FXN59_RS02005	COG2871	sodium ion transport
FXN59_RS02010	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN59_RS02015	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN59_RS02020	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN59_RS02040	COG3056	Lipoprotein
FXN59_RS02060	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FXN59_RS02065	COG1194	a g-specific adenine glycosylase
FXN59_RS02075	COG3171	Protein conserved in bacteria
FXN59_RS02080	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN59_RS02085	COG1178	ABC-type Fe3 transport system permease component
FXN59_RS02090	COG3842	ATPase activity
FXN59_RS02105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FXN59_RS02115	COG1561	YicC-like family, N-terminal region
FXN59_RS02120	COG0354	folic acid binding
FXN59_RS02140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FXN59_RS02145	COG1381	Involved in DNA repair and RecF pathway recombination
FXN59_RS02150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FXN59_RS02155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXN59_RS02160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FXN59_RS02170	COG0500	methyltransferase
FXN59_RS02175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXN59_RS02180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN59_RS02185	COG1309	transcriptional regulator
FXN59_RS02190	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN59_RS02200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FXN59_RS02215	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN59_RS02225	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN59_RS02260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FXN59_RS02270	COG1309	transcriptional regulator
FXN59_RS02285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXN59_RS02290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FXN59_RS02295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FXN59_RS02300	COG4972	Pilus assembly protein
FXN59_RS02330	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FXN59_RS02410	COG3293	Transposase
FXN59_RS02430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FXN59_RS02435	COG0789	Transcriptional regulator
FXN59_RS02440	COG4701	Protein of unknown function (DUF721)
FXN59_RS02455	COG0494	nUDIX hydrolase
FXN59_RS02460	COG1466	dna polymerase III delta subunit
FXN59_RS02465	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FXN59_RS02480	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
FXN59_RS02485	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
FXN59_RS02490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FXN59_RS02495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FXN59_RS02500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXN59_RS02520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FXN59_RS02530	COG4221	oxidoreductase activity
FXN59_RS02535	COG3293	Transposase
FXN59_RS02540	COG0789	Transcriptional regulator
FXN59_RS02545	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FXN59_RS02550	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FXN59_RS02560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FXN59_RS02565	COG4137	Cytochrome C assembly protein
FXN59_RS02570	COG4536	flavin adenine dinucleotide binding
FXN59_RS02575	COG0811	peptide transport
FXN59_RS02580	COG0848	biopolymer transport protein
FXN59_RS02590	COG4783	chaperone-mediated protein folding
FXN59_RS02600	COG0814	amino acid
FXN59_RS02635	COG0747	negative chemotaxis
FXN59_RS02640	COG2853	Lipoprotein
FXN59_RS02675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FXN59_RS02680	COG3610	response to peptide
FXN59_RS02690	COG3293	Transposase
FXN59_RS02705	COG0688	phosphatidylethanolamine metabolic process
FXN59_RS02710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FXN59_RS02720	COG2830	Protein of unknown function (DUF452)
FXN59_RS02725	COG0500	methyltransferase
FXN59_RS02735	COG1399	metal-binding, possibly nucleic acid-binding protein
FXN59_RS02745	COG0416	fatty acid biosynthetic process
FXN59_RS02755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FXN59_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
FXN59_RS02775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FXN59_RS02780	COG0513	Belongs to the DEAD box helicase family
FXN59_RS02785	COG0799	negative regulation of ribosome biogenesis
FXN59_RS02795	COG0768	penicillin binding
FXN59_RS02800	COG0772	Belongs to the SEDS family
FXN59_RS02805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN59_RS02805	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN59_RS02810	COG1686	Belongs to the peptidase S11 family
FXN59_RS02840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN59_RS02845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN59_RS02850	COG0765	amino acid transport
FXN59_RS02855	COG1126	abc transporter atp-binding protein
FXN59_RS02860	COG2168	tRNA wobble position uridine thiolation
FXN59_RS02870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FXN59_RS02875	COG2964	Protein conserved in bacteria
FXN59_RS02880	COG0545	Peptidyl-prolyl cis-trans isomerase
FXN59_RS02890	COG0678	peroxiredoxin activity
FXN59_RS02890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FXN59_RS02895	COG0583	DNA-binding transcription factor activity
FXN59_RS02900	COG1309	transcriptional regulator
FXN59_RS02905	COG1132	(ABC) transporter
FXN59_RS02910	COG4988	ABC transporter
FXN59_RS02915	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FXN59_RS02920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXN59_RS02925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FXN59_RS02935	COG1045	serine acetyltransferase
FXN59_RS02945	COG1494	fructose-1,6-bisphosphatase
FXN59_RS02955	COG0716	FMN binding
FXN59_RS02965	COG0702	epimerase
FXN59_RS02970	COG1733	regulation of RNA biosynthetic process
FXN59_RS02980	COG3312	ion transport
FXN59_RS03000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FXN59_RS03010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FXN59_RS03025	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN59_RS03035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FXN59_RS03055	COG1349	DNA-binding transcription factor activity
FXN59_RS03095	COG0513	Belongs to the DEAD box helicase family
FXN59_RS03105	COG3201	nicotinamide mononucleotide transporter
FXN59_RS03115	COG3501	Rhs element vgr protein
FXN59_RS03120	COG3078	GTPase activator activity
FXN59_RS03130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FXN59_RS03135	COG0456	acetyltransferase
FXN59_RS03145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FXN59_RS03170	COG0511	ligase activity, forming carbon-carbon bonds
FXN59_RS03175	COG0439	Biotin carboxylase
FXN59_RS03180	COG3293	Transposase
FXN59_RS03190	COG4783	chaperone-mediated protein folding
FXN59_RS03195	COG3924	membrane
FXN59_RS03200	COG4145	pantothenate transmembrane transporter activity
FXN59_RS03235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FXN59_RS03240	COG1115	amino acid carrier protein
FXN59_RS03250	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FXN59_RS03255	COG0237	dephospho-CoA kinase activity
FXN59_RS03255	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FXN59_RS03295	COG3161	chorismate lyase activity
FXN59_RS03305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXN59_RS03310	COG1758	RNA polymerase activity
FXN59_RS03320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FXN59_RS03355	COG2801	Transposase and inactivated derivatives
FXN59_RS03375	COG2271	Major facilitator Superfamily
FXN59_RS03385	COG1215	transferase activity, transferring glycosyl groups
FXN59_RS03390	COG1649	PFAM Uncharacterised BCR, COG1649
FXN59_RS03390	COG0726	polysaccharide deacetylase
FXN59_RS03405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FXN59_RS03410	COG0561	phosphatase activity
FXN59_RS03415	COG3716	PTS system mannose fructose sorbose family IID component
FXN59_RS03420	COG3715	PTS system
FXN59_RS03425	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN59_RS03425	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_RS03430	COG0742	ribosomal rna small subunit methyltransferase
FXN59_RS03435	COG0552	protein localization to endoplasmic reticulum
FXN59_RS03440	COG2884	Cell division ATP-binding protein ftsE
FXN59_RS03445	COG2177	Part of the ABC transporter FtsEX involved in
FXN59_RS03460	COG3293	Transposase
FXN59_RS03480	COG1720	tRNA m6t6A37 methyltransferase activity
FXN59_RS03485	COG1575	Belongs to the MenA family. Type 1 subfamily
FXN59_RS03495	COG3293	Transposase
FXN59_RS03500	COG0471	metal ion transport
FXN59_RS03505	COG3028	Belongs to the UPF0307 family
FXN59_RS03510	COG0312	modulator of DNA gyrase
FXN59_RS03515	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FXN59_RS03520	COG1929	Belongs to the glycerate kinase type-1 family
FXN59_RS03535	COG2801	Transposase and inactivated derivatives
FXN59_RS03545	COG0513	Belongs to the DEAD box helicase family
FXN59_RS03550	COG4785	May be involved in cell division
FXN59_RS03560	COG2731	YhcH YjgK YiaL family protein
FXN59_RS03565	COG3023	N-Acetylmuramoyl-L-alanine amidase
FXN59_RS03570	COG4969	Belongs to the N-Me-Phe pilin family
FXN59_RS03615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FXN59_RS03635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FXN59_RS03655	COG2932	Transcriptional regulator
FXN59_RS03675	COG0789	Transcriptional regulator
FXN59_RS03680	COG2608	mercury ion transmembrane transporter activity
FXN59_RS03685	COG2217	Heavy metal translocating P-type atpase
FXN59_RS03690	COG3739	integral membrane protein
FXN59_RS03710	COG0740	serine-type endopeptidase activity
FXN59_RS03715	COG2194	sulfuric ester hydrolase activity
FXN59_RS03720	COG1181	Belongs to the D-alanine--D-alanine ligase family
FXN59_RS03720	COG2918	glutathione biosynthetic process
FXN59_RS03775	COG0459	protein refolding
FXN59_RS03780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FXN59_RS03790	COG1027	Aspartate ammonia-lyase
FXN59_RS03795	COG0859	PFAM glycosyl transferase family 9
FXN59_RS03810	COG3716	PTS system mannose fructose sorbose family IID component
FXN59_RS03815	COG3715	PTS system
FXN59_RS03820	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN59_RS03820	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_RS03825	COG2814	Major facilitator Superfamily
FXN59_RS03830	COG0662	Cupin 2, conserved barrel domain protein
FXN59_RS03830	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FXN59_RS03850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN59_RS03860	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FXN59_RS03870	COG0297	glycogen (starch) synthase activity
FXN59_RS03880	COG2207	Transcriptional regulator
FXN59_RS03880	COG1609	Transcriptional regulator
FXN59_RS03885	COG1757	Na H antiporter
FXN59_RS03890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FXN59_RS03895	COG4214	carbohydrate transport
FXN59_RS03900	COG1129	ABC transporter
FXN59_RS03905	COG4213	ABC transporter substrate-binding protein
FXN59_RS03910	COG2115	Belongs to the xylose isomerase family
FXN59_RS03915	COG1070	Carbohydrate kinase
FXN59_RS03935	COG3070	regulator of competence-specific genes
FXN59_RS03940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FXN59_RS03950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FXN59_RS03955	COG3850	Histidine kinase
FXN59_RS03960	COG3062	negative regulation of establishment of protein localization
FXN59_RS03965	COG0243	molybdopterin cofactor binding
FXN59_RS03970	COG0437	4 iron, 4 sulfur cluster binding
FXN59_RS03975	COG0348	domain, Protein
FXN59_RS03980	COG3043	anaerobic respiration
FXN59_RS03985	COG3005	denitrification pathway
FXN59_RS03990	COG0754	glutathionylspermidine amidase activity
FXN59_RS03995	COG0859	PFAM glycosyl transferase family 9
FXN59_RS04005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN59_RS04015	COG0737	Belongs to the 5'-nucleotidase family
FXN59_RS04035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN59_RS04040	COG1028	Short-chain dehydrogenase reductase Sdr
FXN59_RS04050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN59_RS04105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FXN59_RS04130	COG1011	Hydrolase
FXN59_RS04140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FXN59_RS04145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FXN59_RS04165	COG1555	photosystem II stabilization
FXN59_RS04165	COG1596	polysaccharide export
FXN59_RS04170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FXN59_RS04175	COG0561	phosphatase activity
FXN59_RS04180	COG1040	competence protein
FXN59_RS04195	COG1114	Component of the transport system for branched-chain amino acids
FXN59_RS04220	COG4545	Glutaredoxin-related protein
FXN59_RS04230	COG2221	Nitrite and sulphite reductase 4Fe-4S
FXN59_RS04230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXN59_RS04235	COG3381	protein complex oligomerization
FXN59_RS04240	COG3302	dmso reductase anchor subunit
FXN59_RS04245	COG0437	4 iron, 4 sulfur cluster binding
FXN59_RS04250	COG0243	molybdopterin cofactor binding
FXN59_RS04260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FXN59_RS04260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FXN59_RS04270	COG5645	(Lipo)protein
FXN59_RS04275	COG0210	DNA helicase
FXN59_RS04305	COG0110	maltose O-acetyltransferase activity
FXN59_RS04320	COG3293	Transposase
FXN59_RS04360	COG2095	MarC family integral membrane protein
FXN59_RS04365	COG0488	(ABC) transporter
FXN59_RS04370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FXN59_RS04375	COG2137	regulation of response to DNA damage stimulus
FXN59_RS04380	COG0251	oxidation-reduction process
FXN59_RS04390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FXN59_RS04430	COG2369	cell adhesion
FXN59_RS04455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FXN59_RS04460	COG0084	hydrolase, TatD family'
FXN59_RS04465	COG0602	queuosine metabolic process
FXN59_RS04470	COG1328	CTP reductase activity
FXN59_RS04470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXN59_RS04485	COG1022	Amp-dependent synthetase and ligase
FXN59_RS04490	COG0587	DNA-directed DNA polymerase activity
FXN59_RS04505	COG0753	catalase activity
FXN59_RS04510	COG3293	Transposase
FXN59_RS04515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FXN59_RS04520	COG0165	Argininosuccinate lyase
FXN59_RS04555	COG0582	viral genome integration into host DNA
FXN59_RS04620	COG1598	PFAM Uncharacterised protein family UPF0150
FXN59_RS04635	COG3293	Transposase
FXN59_RS04655	COG1869	D-ribose catabolic process
FXN59_RS04665	COG0730	response to heat
FXN59_RS04685	COG0590	tRNA wobble adenosine to inosine editing
FXN59_RS04715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FXN59_RS04720	COG4942	peptidase
FXN59_RS04725	COG2861	carbohydrate metabolic process
FXN59_RS04730	COG0606	chelatase, subunit chli
FXN59_RS04760	COG3293	Transposase
FXN59_RS04835	COG3293	Transposase
FXN59_RS04850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FXN59_RS04880	COG2990	Protein conserved in bacteria
FXN59_RS04885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FXN59_RS04905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FXN59_RS04990	COG4964	Belongs to the GSP D family
FXN59_RS05020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FXN59_RS05030	COG1444	tRNA N-acetyltransferase activity
FXN59_RS05035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FXN59_RS05045	COG1126	abc transporter atp-binding protein
FXN59_RS05050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN59_RS05055	COG4215	(ABC) transporter
FXN59_RS05060	COG4160	amino acid transport
FXN59_RS05065	COG1966	Carbon starvation protein
FXN59_RS05080	COG3116	cell division
FXN59_RS05085	COG0768	penicillin binding
FXN59_RS05095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FXN59_RS05105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FXN59_RS05115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FXN59_RS05130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FXN59_RS05135	COG0849	cell division
FXN59_RS05140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FXN59_RS05150	COG1605	Chorismate mutase
FXN59_RS05150	COG0077	Prephenate dehydratase
FXN59_RS05155	COG0326	Molecular chaperone. Has ATPase activity
FXN59_RS05160	COG1393	Belongs to the ArsC family
FXN59_RS05170	COG1876	peptidase activity
FXN59_RS05175	COG0494	nUDIX hydrolase
FXN59_RS05180	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FXN59_RS05225	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FXN59_RS05235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FXN59_RS05240	COG1053	succinate dehydrogenase
FXN59_RS05255	COG1120	ATPase activity
FXN59_RS05260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN59_RS05265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN59_RS05270	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FXN59_RS05275	COG1408	metallophosphoesterase
FXN59_RS05285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FXN59_RS05290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FXN59_RS05325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXN59_RS05335	COG0741	lytic transglycosylase activity
FXN59_RS05340	COG2350	Protein conserved in bacteria
FXN59_RS05345	COG1607	acyl-coa hydrolase
FXN59_RS05370	COG0497	DNA recombination
FXN59_RS05380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FXN59_RS05390	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FXN59_RS05390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN59_RS05395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN59_RS05400	COG5002	protein histidine kinase activity
FXN59_RS05400	COG0784	Response regulator, receiver
FXN59_RS05400	COG2198	Histidine kinase
FXN59_RS05405	COG3293	Transposase
FXN59_RS05415	COG1129	ABC transporter
FXN59_RS05420	COG1879	ABC-type sugar transport system periplasmic component
FXN59_RS05425	COG1609	Transcriptional regulator
FXN59_RS05430	COG1085	galactose-1-phosphate uridylyltransferase
FXN59_RS05435	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FXN59_RS05440	COG2017	converts alpha-aldose to the beta-anomer
FXN59_RS05455	COG0471	metal ion transport
FXN59_RS05460	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FXN59_RS05460	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
FXN59_RS05465	COG3051	citrate lyase alpha subunit
FXN59_RS05470	COG2301	Belongs to the HpcH HpaI aldolase family
FXN59_RS05480	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
FXN59_RS05490	COG4535	Mg2 and Co2 transporter CorC
FXN59_RS05510	COG0105	UTP biosynthetic process
FXN59_RS05530	COG4942	peptidase
FXN59_RS05530	COG1388	LysM domain
FXN59_RS05540	COG1238	metal cluster binding
FXN59_RS05570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FXN59_RS05660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FXN59_RS05670	COG0733	neurotransmitter:sodium symporter activity
FXN59_RS05680	COG1285	pathogenesis
FXN59_RS05740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXN59_RS05740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXN59_RS05740	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FXN59_RS05745	COG1105	Belongs to the carbohydrate kinase PfkB family
FXN59_RS05750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_RS05750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_RS05760	COG0746	molybdenum cofactor guanylyltransferase activity
FXN59_RS05765	COG3084	Protein conserved in bacteria
FXN59_RS05770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN59_RS05775	COG3085	chromosome segregation
FXN59_RS05825	COG0561	phosphatase activity
FXN59_RS05870	COG1349	DNA-binding transcription factor activity
FXN59_RS05875	COG0347	Belongs to the P(II) protein family
FXN59_RS05880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FXN59_RS05885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FXN59_RS05890	COG0470	DNA polymerase III
FXN59_RS05895	COG0084	hydrolase, TatD family'
FXN59_RS05905	COG1253	flavin adenine dinucleotide binding
FXN59_RS05925	COG2190	(PTS) system
FXN59_RS05925	COG1263	PTS System
FXN59_RS05925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN59_RS05930	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
FXN59_RS05940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FXN59_RS05945	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FXN59_RS05955	COG1737	Transcriptional regulator
FXN59_RS05960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXN59_RS05965	COG0363	glucosamine-6-phosphate deaminase activity
FXN59_RS05970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FXN59_RS05975	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FXN59_RS05995	COG3293	Transposase
FXN59_RS06020	COG2363	Small membrane protein
FXN59_RS06025	COG1643	Atp-dependent helicase
FXN59_RS06045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FXN59_RS06055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN59_RS06060	COG0577	efflux transmembrane transporter activity
FXN59_RS06060	COG1136	(ABC) transporter
FXN59_RS06070	COG1136	(ABC) transporter
FXN59_RS06070	COG0577	efflux transmembrane transporter activity
FXN59_RS06085	COG0672	)-iron permease
FXN59_RS06090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXN59_RS06100	COG0316	Belongs to the HesB IscA family
FXN59_RS06105	COG0024	Methionine aminopeptidase
FXN59_RS06115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FXN59_RS06120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FXN59_RS06165	COG4172	Belongs to the ABC transporter superfamily
FXN59_RS06170	COG4172	Belongs to the ABC transporter superfamily
FXN59_RS06175	COG4171	peptide transport system, permease
FXN59_RS06180	COG4168	peptide transport system, permease
FXN59_RS06185	COG4166	transmembrane transport
FXN59_RS06190	COG3106	COG3106 Predicted ATPase
FXN59_RS06200	COG3283	Transcriptional regulator of aromatic amino acids metabolism
FXN59_RS06205	COG1923	regulation of RNA biosynthetic process
FXN59_RS06215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FXN59_RS06220	COG1388	LysM domain
FXN59_RS06220	COG0860	N-Acetylmuramoyl-L-alanine amidase
FXN59_RS06225	COG0802	atpase or kinase
FXN59_RS06245	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FXN59_RS06255	COG2194	sulfuric ester hydrolase activity
FXN59_RS06275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_RS06280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FXN59_RS06285	COG2190	(PTS) system
FXN59_RS06290	COG0339	signal peptide processing
FXN59_RS06295	COG2832	Protein of unknown function (DUF454)
FXN59_RS06300	COG4166	transmembrane transport
FXN59_RS06335	COG3008	intermembrane lipid transfer
FXN59_RS06340	COG2995	paraquat-inducible protein a
FXN59_RS06350	COG0793	Belongs to the peptidase S41A family
FXN59_RS06355	COG2989	Protein conserved in bacteria
FXN59_RS06360	COG3108	Peptidase M15
FXN59_RS06365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN59_RS06370	COG0567	Dehydrogenase, E1 component
FXN59_RS06375	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXN59_RS06385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FXN59_RS06515	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FXN59_RS06525	COG3260	NADH ubiquinone oxidoreductase 20
FXN59_RS06530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXN59_RS06540	COG0651	ATP synthesis coupled electron transport
FXN59_RS06545	COG4237	Hydrogenase 4 membrane
FXN59_RS06575	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FXN59_RS06580	COG2864	formate dehydrogenase
FXN59_RS06585	COG0437	4 iron, 4 sulfur cluster binding
FXN59_RS06605	COG1609	Transcriptional regulator
FXN59_RS06610	COG3265	gluconokinase activity
FXN59_RS06615	COG2610	gluconate transmembrane transporter activity
FXN59_RS06620	COG0210	DNA helicase
FXN59_RS06630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FXN59_RS06635	COG4115	mRNA cleavage
FXN59_RS06640	COG2161	toxin-antitoxin pair type II binding
FXN59_RS06645	COG5039	Polysaccharide pyruvyl transferase
FXN59_RS06655	COG3293	Transposase
FXN59_RS06660	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN59_RS06670	COG1216	Glycosyl transferase, family 2
FXN59_RS06675	COG1216	Glycosyl transferase, family 2
FXN59_RS06680	COG2951	lytic endotransglycosylase activity
FXN59_RS06685	COG0708	Exodeoxyribonuclease III
FXN59_RS06690	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FXN59_RS06695	COG1088	dTDP-glucose 4,6-dehydratase activity
FXN59_RS06710	COG0671	phosphoesterase, PA-phosphatase related
FXN59_RS06730	COG0515	serine threonine protein kinase
FXN59_RS06735	COG1946	Acyl-CoA thioesterase
FXN59_RS06745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FXN59_RS06750	COG4988	ABC transporter
FXN59_RS06755	COG0492	ferredoxin-NADP+ reductase activity
FXN59_RS06760	COG3118	belongs to the thioredoxin family
FXN59_RS06770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FXN59_RS06775	COG0303	'Molybdopterin
FXN59_RS06785	COG2027	D-alanyl-D-alanine carboxypeptidase
FXN59_RS06790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXN59_RS06795	COG1534	Rna-binding protein
FXN59_RS06800	COG3657	addiction module killer protein
FXN59_RS06805	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXN59_RS06810	COG0307	riboflavin synthase, alpha
FXN59_RS06820	COG4774	siderophore transport
FXN59_RS06825	COG4178	(ABC) transporter
FXN59_RS06830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FXN59_RS06835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FXN59_RS06845	COG3102	Protein conserved in bacteria
FXN59_RS06850	COG3133	Outer membrane lipoprotein
FXN59_RS06855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FXN59_RS06860	COG2890	protein-(glutamine-N5) methyltransferase activity
FXN59_RS06870	COG0791	NLP P60 protein
FXN59_RS06880	COG3100	YcgL domain-containing protein
FXN59_RS06895	COG2062	phosphohistidine phosphatase, SixA
FXN59_RS06905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FXN59_RS06910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FXN59_RS06920	COG2932	Transcriptional regulator
FXN59_RS06930	COG0517	IMP dehydrogenase activity
FXN59_RS06930	COG0516	GMP reductase activity
FXN59_RS07005	COG0195	Participates in both transcription termination and antitermination
FXN59_RS07065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FXN59_RS07090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FXN59_RS07095	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FXN59_RS07110	COG3842	ATPase activity
FXN59_RS07120	COG0395	ABC-type sugar transport system, permease component
FXN59_RS07130	COG0322	excinuclease ABC activity
FXN59_RS07140	COG2835	tetraacyldisaccharide 4'-kinase activity
FXN59_RS07145	COG1663	tetraacyldisaccharide 4'-kinase activity
FXN59_RS07155	COG0658	competence protein
FXN59_RS07155	COG2333	competence protein COMEC
FXN59_RS07160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FXN59_RS07170	COG0617	tRNA 3'-terminal CCA addition
FXN59_RS07175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FXN59_RS07185	COG0280	phosphate acetyltransferase
FXN59_RS07185	COG0857	belongs to the CobB CobQ family
FXN59_RS07190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FXN59_RS07195	COG3092	negative regulation of chromosome organization
FXN59_RS07200	COG1286	toxin biosynthetic process
FXN59_RS07205	COG1640	4-alpha-glucanotransferase
FXN59_RS07210	COG0058	SHG alpha-glucan phosphorylase activity
FXN59_RS07215	COG2909	trisaccharide binding
FXN59_RS07225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FXN59_RS07230	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXN59_RS07235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXN59_RS07240	COG0778	Nitroreductase
FXN59_RS07245	COG0616	signal peptide processing
FXN59_RS07250	COG1605	Chorismate mutase
FXN59_RS07250	COG0287	Prephenate dehydrogenase
FXN59_RS07255	COG0009	L-threonylcarbamoyladenylate synthase
FXN59_RS07265	COG0583	DNA-binding transcription factor activity
FXN59_RS07285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXN59_RS07290	COG2949	membrane
FXN59_RS07325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FXN59_RS07340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN59_RS07345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FXN59_RS07350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN59_RS07355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FXN59_RS07360	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
FXN59_RS07365	COG0310	cobalt ion transport
FXN59_RS07370	COG0310	cobalt ion transport
FXN59_RS07375	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FXN59_RS07380	COG1122	ATPase activity
FXN59_RS07390	COG0409	Hydrogenase expression formation protein
FXN59_RS07440	COG0629	single-stranded DNA binding
FXN59_RS07460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXN59_RS07465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FXN59_RS07470	COG0795	lipopolysaccharide-transporting ATPase activity
FXN59_RS07475	COG0795	lipopolysaccharide-transporting ATPase activity
FXN59_RS07485	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FXN59_RS07490	COG4149	molybdate abc transporter
FXN59_RS07495	COG0725	ABC transporter, periplasmic molybdate-binding protein
FXN59_RS07500	COG2005	Transcriptional regulator
FXN59_RS07505	COG0471	metal ion transport
FXN59_RS07515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXN59_RS07520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXN59_RS07520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXN59_RS07525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXN59_RS07535	COG0583	DNA-binding transcription factor activity
FXN59_RS07540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FXN59_RS07555	COG0039	L-malate dehydrogenase activity
FXN59_RS07560	COG1438	arginine binding
FXN59_RS07565	COG1090	epimerase
FXN59_RS07570	COG4657	Part of a membrane complex involved in electron transport
FXN59_RS07580	COG4656	Part of a membrane complex involved in electron transport
FXN59_RS07600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FXN59_RS07605	COG0733	neurotransmitter:sodium symporter activity
FXN59_RS07610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN59_RS07620	COG0739	heme binding
FXN59_RS07625	COG4604	ABC transporter, ATP-binding protein
FXN59_RS07630	COG4605	iron ion homeostasis
FXN59_RS07635	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN59_RS07640	COG4607	ABC-type enterochelin transport system periplasmic component
FXN59_RS07645	COG0737	Belongs to the 5'-nucleotidase family
FXN59_RS07660	COG3111	PFAM Bacterial OB fold (BOF) protein
FXN59_RS07665	COG0745	RESPONSE REGULATOR receiver
FXN59_RS07670	COG0642	Histidine kinase
FXN59_RS07675	COG0405	Gamma-glutamyltransferase
FXN59_RS07690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN59_RS07695	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FXN59_RS07700	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FXN59_RS07755	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FXN59_RS07765	COG0583	DNA-binding transcription factor activity
FXN59_RS07770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FXN59_RS07775	COG1687	branched-chain amino acid
FXN59_RS07780	COG0612	Peptidase, M16
FXN59_RS07785	COG4771	TonB-dependent receptor
FXN59_RS07790	COG2990	Protein conserved in bacteria
FXN59_RS07800	COG0539	negative regulation of cytoplasmic translation
FXN59_RS07805	COG0776	regulation of translation
FXN59_RS07810	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FXN59_RS07815	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FXN59_RS07825	COG0023	Translation Initiation Factor
FXN59_RS07830	COG3094	Invasion gene expression up-regulator, SirB
FXN59_RS07835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FXN59_RS07840	COG0735	belongs to the Fur family
FXN59_RS07845	COG0716	FMN binding
FXN59_RS07855	COG0596	Alpha beta hydrolase
FXN59_RS07860	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FXN59_RS07865	COG0318	PFAM AMP-dependent synthetase and ligase
FXN59_RS07870	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FXN59_RS07870	COG3264	Mechanosensitive ion channel
FXN59_RS07875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FXN59_RS07880	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FXN59_RS07885	COG0730	response to heat
FXN59_RS07890	COG1560	Kdo2-lipid A biosynthetic process
FXN59_RS07900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FXN59_RS07910	COG0463	Glycosyl transferase, family 2
FXN59_RS07925	COG2932	Transcriptional regulator
FXN59_RS07930	COG3423	Transcriptional regulator
FXN59_RS07935	COG2801	Transposase and inactivated derivatives
FXN59_RS07940	COG0251	oxidation-reduction process
FXN59_RS07955	COG1757	Na H antiporter
FXN59_RS07960	COG3293	Transposase
FXN59_RS07965	COG2916	Histone family protein nucleoid-structuring protein H-NS
FXN59_RS07970	COG0788	formyltetrahydrofolate deformylase activity
FXN59_RS07980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FXN59_RS07990	COG3842	ATPase activity
FXN59_RS07995	COG1178	ABC-type Fe3 transport system permease component
FXN59_RS08000	COG3842	ATPase activity
FXN59_RS08030	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FXN59_RS08035	COG3098	single-species biofilm formation
FXN59_RS08050	COG1278	Cold shock
FXN59_RS08060	COG1067	ATP-dependent peptidase activity
FXN59_RS08065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FXN59_RS08075	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FXN59_RS08080	COG1074	ATP-dependent DNA helicase activity
FXN59_RS08085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXN59_RS08105	COG0101	tRNA pseudouridine synthase activity
FXN59_RS08110	COG2026	Addiction module toxin, RelE StbE family
FXN59_RS08120	COG0471	metal ion transport
FXN59_RS08125	COG2315	Protein conserved in bacteria
FXN59_RS08135	COG3005	denitrification pathway
FXN59_RS08160	COG3293	Transposase
FXN59_RS08220	COG1346	cytolysis
FXN59_RS08235	COG3657	addiction module killer protein
FXN59_RS08240	COG0488	(ABC) transporter
FXN59_RS08270	COG3293	Transposase
FXN59_RS08325	COG3423	Transcriptional regulator
FXN59_RS08330	COG2932	Transcriptional regulator
FXN59_RS08340	COG0586	Pfam SNARE associated Golgi protein
FXN59_RS08345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FXN59_RS08355	COG1686	Belongs to the peptidase S11 family
FXN59_RS08360	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FXN59_RS08370	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FXN59_RS08375	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FXN59_RS08380	COG0697	spore germination
FXN59_RS08385	COG2925	Exonuclease
FXN59_RS08395	COG2801	Transposase and inactivated derivatives
FXN59_RS08400	COG2801	Transposase and inactivated derivatives
FXN59_RS08525	COG1528	Iron-storage protein
FXN59_RS08530	COG1528	Iron-storage protein
FXN59_RS08535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FXN59_RS08540	COG0589	response to stress
FXN59_RS08560	COG0613	PHP domain protein
FXN59_RS08565	COG0167	dihydroorotate dehydrogenase activity
FXN59_RS08570	COG0308	aminopeptidase N
FXN59_RS08575	COG1448	Aminotransferase
FXN59_RS08585	COG3293	Transposase
FXN59_RS08620	COG0791	NLP P60 protein
FXN59_RS08635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FXN59_RS08650	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FXN59_RS08650	COG0517	IMP dehydrogenase activity
FXN59_RS08655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FXN59_RS08660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FXN59_RS08665	COG0512	Glutamine amidotransferase of anthranilate synthase
FXN59_RS08670	COG1942	4-Oxalocrotonate Tautomerase
FXN59_RS08680	COG0134	indole-3-glycerol-phosphate synthase activity
FXN59_RS08680	COG0135	phosphoribosylanthranilate isomerase activity
FXN59_RS08695	COG0298	carbon dioxide binding
FXN59_RS08710	COG3293	Transposase
FXN59_RS08715	COG3630	sodium ion export across plasma membrane
FXN59_RS08750	COG4221	oxidoreductase activity
FXN59_RS08765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN59_RS08775	COG0469	pyruvate kinase activity
FXN59_RS08790	COG1879	ABC-type sugar transport system periplasmic component
FXN59_RS08810	COG2390	Transcriptional regulator
FXN59_RS08830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FXN59_RS08835	COG1940	carbohydrate kinase activity
FXN59_RS08845	COG2969	positive regulation of protein catabolic process
FXN59_RS08855	COG0314	molybdopterin synthase activity
FXN59_RS08860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FXN59_RS08870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FXN59_RS08920	COG3293	Transposase
FXN59_RS08930	COG2801	Transposase and inactivated derivatives
FXN59_RS08955	COG1120	ATPase activity
FXN59_RS08965	COG3585	molybdate ion transport
FXN59_RS08975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN59_RS08980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FXN59_RS08990	COG4774	siderophore transport
FXN59_RS09015	COG2166	iron-sulfur cluster assembly
FXN59_RS09020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FXN59_RS09020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FXN59_RS09025	COG1560	Kdo2-lipid A biosynthetic process
FXN59_RS09030	COG3381	protein complex oligomerization
FXN59_RS09035	COG2249	NAD(P)H dehydrogenase (quinone) activity
FXN59_RS09045	COG0330	HflC and HflK could
FXN59_RS09070	COG1858	cytochrome C peroxidase
FXN59_RS09075	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FXN59_RS09080	COG0318	PFAM AMP-dependent synthetase and ligase
FXN59_RS09085	COG3065	identical protein binding
FXN59_RS09090	COG1214	PFAM Peptidase M22, glycoprotease
FXN59_RS09095	COG1199	ATP-dependent helicase activity
FXN59_RS09100	COG0676	glucose-6-phosphate 1-epimerase activity
FXN59_RS09110	COG4580	involved in the transport of maltose and maltodextrins
FXN59_RS09115	COG3842	ATPase activity
FXN59_RS09120	COG2182	Extracellular solute-binding protein
FXN59_RS09130	COG3833	ABC-type maltose transport systems, permease component
FXN59_RS09135	COG0366	Alpha amylase catalytic
FXN59_RS09140	COG3842	ATPase activity
FXN59_RS09150	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN59_RS09165	COG0732	type I restriction modification DNA specificity domain
FXN59_RS09185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN59_RS09195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN59_RS09205	COG0633	Ferredoxin
FXN59_RS09220	COG1280	lysine exporter protein (LysE YggA)
FXN59_RS09225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FXN59_RS09230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FXN59_RS09240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FXN59_RS09245	COG3293	Transposase
FXN59_RS09255	COG0166	Belongs to the GPI family
FXN59_RS09265	COG0305	Participates in initiation and elongation during chromosome replication
FXN59_RS09270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FXN59_RS09275	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXN59_RS09280	COG1136	(ABC) transporter
FXN59_RS09285	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXN59_RS09330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN59_RS09335	COG1136	(ABC) transporter
FXN59_RS09335	COG0577	efflux transmembrane transporter activity
FXN59_RS09340	COG1538	Outer membrane efflux protein
FXN59_RS09350	COG2824	Alkylphosphonate utilization operon protein PhnA
FXN59_RS09360	COG0564	pseudouridine synthase activity
FXN59_RS09365	COG2431	L-lysine efflux transmembrane transporter activity
FXN59_RS09375	COG0406	alpha-ribazole phosphatase activity
FXN59_RS09380	COG0285	dihydrofolate synthase activity
FXN59_RS09395	COG0142	geranyltranstransferase activity
FXN59_RS09405	COG1349	DNA-binding transcription factor activity
FXN59_RS09410	COG1063	alcohol dehydrogenase
FXN59_RS09420	COG3414	Phosphotransferase system galactitol-specific IIB component
FXN59_RS09425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_RS09435	COG3684	Belongs to the aldolase LacD family
FXN59_RS09445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FXN59_RS09450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FXN59_RS09500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXN59_RS09505	COG0512	Glutamine amidotransferase of anthranilate synthase
FXN59_RS09515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FXN59_RS09585	COG1846	Transcriptional regulator
FXN59_RS09585	COG1940	carbohydrate kinase activity
FXN59_RS09595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN59_RS09600	COG2226	methyltransferase
FXN59_RS09610	COG3293	Transposase
FXN59_RS09615	COG3422	double-strand break repair
FXN59_RS09630	COG3105	Protein conserved in bacteria
FXN59_RS09635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXN59_RS09655	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FXN59_RS09660	COG3683	transport system, periplasmic component
FXN59_RS09665	COG0488	(ABC) transporter
FXN59_RS09675	COG3293	Transposase
FXN59_RS09680	COG0187	DNA topoisomerase II activity
FXN59_RS09690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FXN59_RS09695	COG0625	glutathione transferase activity
FXN59_RS09700	COG3047	cAMP biosynthetic process
FXN59_RS09700	COG2885	chlorophyll binding
FXN59_RS09705	COG0616	signal peptide processing
FXN59_RS09710	COG3293	Transposase
FXN59_RS09720	COG1252	NADH dehydrogenase
FXN59_RS09730	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FXN59_RS09740	COG0792	nuclease activity
FXN59_RS09745	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FXN59_RS09750	COG2823	Periplasmic or secreted lipoprotein
FXN59_RS09760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXN59_RS09760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXN59_RS09765	COG0785	Cytochrome C biogenesis protein
FXN59_RS09770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN59_RS09785	COG2801	Transposase and inactivated derivatives
FXN59_RS09795	COG3069	C4-dicarboxylate transmembrane transporter activity
FXN59_RS09805	COG3077	Addiction module antitoxin, RelB DinJ family
FXN59_RS09810	COG3041	Addiction module toxin RelE StbE family
FXN59_RS09825	COG2351	hydroxyisourate hydrolase activity
FXN59_RS09830	COG0825	malonyl-CoA metabolic process
FXN59_RS09845	COG2252	PERMEase
FXN59_RS09850	COG3152	Membrane
FXN59_RS09855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FXN59_RS09860	COG0375	protein maturation
FXN59_RS09865	COG2814	Major facilitator Superfamily
FXN59_RS09870	COG0563	adenylate kinase activity
FXN59_RS09875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FXN59_RS09880	COG3025	triphosphatase activity
FXN59_RS09885	COG1392	Phosphate transport regulator
FXN59_RS09890	COG0306	phosphate transporter
FXN59_RS09895	COG4991	sh3 domain protein
FXN59_RS09905	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FXN59_RS09910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FXN59_RS09925	COG1620	l-lactate permease
FXN59_RS09945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FXN59_RS09990	COG0826	peptidase U32
FXN59_RS10000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FXN59_RS10010	COG1862	Preprotein translocase
FXN59_RS10015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FXN59_RS10020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FXN59_RS10030	COG1454	alcohol dehydrogenase
FXN59_RS10030	COG1012	belongs to the aldehyde dehydrogenase family
FXN59_RS10035	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXN59_RS10070	COG0720	synthase
FXN59_RS10075	COG0602	queuosine metabolic process
FXN59_RS10080	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FXN59_RS10085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FXN59_RS10095	COG0783	Belongs to the Dps family
FXN59_RS10100	COG1566	PFAM secretion protein HlyD family protein
FXN59_RS10105	COG2814	Major facilitator Superfamily
FXN59_RS10155	COG2927	DNA polymerase III (CHI subunit)
FXN59_RS10160	COG0114	fumarate hydratase activity
FXN59_RS10165	COG2268	Band 7 protein
FXN59_RS10180	COG0778	Nitroreductase
FXN59_RS10185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FXN59_RS10195	COG0814	amino acid
FXN59_RS10215	COG3392	D12 class N6 adenine-specific DNA methyltransferase
FXN59_RS10270	COG0235	Class ii aldolase
FXN59_RS10275	COG3623	hexulose-6-phosphate isomerase
FXN59_RS10300	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FXN59_RS10335	COG3293	Transposase
FXN59_RS10350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXN59_RS10355	COG3962	Belongs to the TPP enzyme family
FXN59_RS10365	COG0673	inositol 2-dehydrogenase activity
FXN59_RS10370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN59_RS10375	COG2274	protein secretion by the type I secretion system
FXN59_RS10380	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FXN59_RS10385	COG2994	toxin metabolic process
FXN59_RS10395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FXN59_RS10415	COG2813	Specifically methylates the guanine in position
FXN59_RS10420	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
FXN59_RS10425	COG0456	acetyltransferase
FXN59_RS10430	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FXN59_RS10450	COG2165	general secretion pathway protein
FXN59_RS10475	COG3064	Membrane
FXN59_RS10480	COG0848	biopolymer transport protein
FXN59_RS10485	COG0811	peptide transport
FXN59_RS10490	COG0824	Thioesterase
FXN59_RS10505	COG1294	oxidase, subunit
FXN59_RS10510	COG1271	oxidase subunit
FXN59_RS10540	COG0217	transcriptional regulatory protein
FXN59_RS10545	COG0494	nUDIX hydrolase
FXN59_RS10560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FXN59_RS10565	COG3293	Transposase
FXN59_RS10570	COG1755	Isoprenylcysteine carboxyl methyltransferase
FXN59_RS10585	COG2271	Major facilitator Superfamily
FXN59_RS10595	COG0346	lactoylglutathione lyase activity
FXN59_RS10600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXN59_RS10605	COG2056	Na+-H+ antiporter family
FXN59_RS10630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FXN59_RS10635	COG0142	geranyltranstransferase activity
FXN59_RS10650	COG0697	spore germination
FXN59_RS10655	COG0697	spore germination
FXN59_RS10660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FXN59_RS10670	COG4166	transmembrane transport
FXN59_RS10675	COG0601	transmembrane transport
FXN59_RS10680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FXN59_RS10685	COG0444	Belongs to the ABC transporter superfamily
FXN59_RS10690	COG4608	Belongs to the ABC transporter superfamily
FXN59_RS10695	COG0745	RESPONSE REGULATOR receiver
FXN59_RS10710	COG1611	Belongs to the LOG family
FXN59_RS10720	COG2259	Doxx family
FXN59_RS10730	COG1530	ribonuclease E activity
FXN59_RS10750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXN59_RS10755	COG0626	cystathionine gamma-synthase activity
FXN59_RS10790	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FXN59_RS10795	COG1959	2 iron, 2 sulfur cluster binding
FXN59_RS10805	COG0822	iron-sulfur transferase activity
FXN59_RS10820	COG0443	Heat shock 70 kDa protein
FXN59_RS10825	COG0633	Ferredoxin
FXN59_RS10830	COG2975	iron-sulfur cluster assembly
FXN59_RS10835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXN59_RS10835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXN59_RS10840	COG0489	protein tyrosine kinase activity
FXN59_RS10855	COG2801	Transposase and inactivated derivatives
FXN59_RS10915	COG3842	ATPase activity
FXN59_RS10920	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN59_RS10925	COG1177	transmembrane transport
FXN59_RS10930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN59_RS10945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FXN59_RS10950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FXN59_RS10965	COG1522	sequence-specific DNA binding
FXN59_RS10975	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FXN59_RS10980	COG1178	ABC-type Fe3 transport system permease component
FXN59_RS10985	COG4143	(ABC) transporter
FXN59_RS11005	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FXN59_RS11025	COG2920	part of a sulfur-relay system
FXN59_RS11035	COG1121	(ABC) transporter
FXN59_RS11040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN59_RS11045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN59_RS11065	COG3304	Inner membrane component domain
FXN59_RS11070	COG1289	transmembrane transporter activity
FXN59_RS11085	COG3958	Transketolase
FXN59_RS11090	COG3959	Transketolase, thiamine diphosphate binding domain
FXN59_RS11130	COG4953	penicillin-binding protein 1C
FXN59_RS11135	COG3293	Transposase
FXN59_RS11140	COG2855	membrane
FXN59_RS11155	COG0157	Belongs to the NadC ModD family
FXN59_RS11160	COG3842	ATPase activity
FXN59_RS11165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FXN59_RS11170	COG0725	ABC transporter, periplasmic molybdate-binding protein
FXN59_RS11180	COG5339	Protein conserved in bacteria
FXN59_RS11185	COG0443	Heat shock 70 kDa protein
FXN59_RS11190	COG0484	heat shock protein binding
FXN59_RS11195	COG2337	Toxic component of a toxin-antitoxin (TA) module
FXN59_RS11210	COG0626	cystathionine gamma-synthase activity
FXN59_RS11215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FXN59_RS11245	COG1487	ribonuclease activity
FXN59_RS11255	COG2337	Toxic component of a toxin-antitoxin (TA) module
FXN59_RS11280	COG3021	interspecies interaction between organisms
FXN59_RS11310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FXN59_RS11335	COG3177	Filamentation induced by cAMP protein fic
FXN59_RS11395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FXN59_RS11400	COG2999	glutathione oxidoreductase activity
FXN59_RS11410	COG1530	ribonuclease E activity
FXN59_RS11415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXN59_RS11440	COG3293	Transposase
FXN59_RS11450	COG3293	Transposase
FXN59_RS11475	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN59_RS11480	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN59_RS11500	COG2801	Transposase and inactivated derivatives
FXN59_RS11505	COG3293	Transposase
FXN59_RS11515	COG2860	membrane
FXN59_RS11525	COG3293	Transposase
FXN59_RS11535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FXN59_RS11545	COG3293	Transposase
FXN59_RS11550	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FXN59_RS11555	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FXN59_RS11560	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FXN59_RS11565	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FXN59_RS11590	COG2850	peptidyl-arginine hydroxylation
FXN59_RS11605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_RS11610	COG1137	ATPase activity
FXN59_RS11615	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FXN59_RS11620	COG3117	lipopolysaccharide transmembrane transporter activity
FXN59_RS11625	COG1127	ABC transporter
FXN59_RS11630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FXN59_RS11635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FXN59_RS11640	COG2854	intermembrane phospholipid transfer
FXN59_RS11645	COG3113	response to antibiotic
FXN59_RS11650	COG5007	Belongs to the BolA IbaG family
FXN59_RS11675	COG3691	Protein conserved in bacteria
FXN59_RS11685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FXN59_RS11695	COG0861	Integral membrane protein TerC family
FXN59_RS11705	COG1217	gtp-binding protein TYPA
FXN59_RS11720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FXN59_RS11725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXN59_RS11745	COG1125	glycine betaine transport
FXN59_RS11745	COG0517	IMP dehydrogenase activity
FXN59_RS11750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FXN59_RS11760	COG0460	homoserine dehydrogenase
FXN59_RS11760	COG0527	aspartate kinase activity
FXN59_RS11775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FXN59_RS11780	COG2091	lysine biosynthetic process via aminoadipic acid
FXN59_RS11785	COG0330	HflC and HflK could
FXN59_RS11790	COG0330	HflC and HflK could
FXN59_RS11805	COG4974	Belongs to the 'phage' integrase family
FXN59_RS11810	COG2814	Major facilitator Superfamily
FXN59_RS11815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FXN59_RS11830	COG3061	Opacity-associated protein A
FXN59_RS11830	COG3266	domain, Protein
FXN59_RS11835	COG1509	lysine 2,3-aminomutase activity
FXN59_RS11845	COG3033	Beta-eliminating lyase
FXN59_RS11850	COG0814	amino acid
FXN59_RS11855	COG2964	Protein conserved in bacteria
FXN59_RS11860	COG5413	integral membrane protein
FXN59_RS11870	COG0204	Acyl-transferase
FXN59_RS11880	COG0697	spore germination
FXN59_RS11885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FXN59_RS11890	COG1882	Formate acetyltransferase
FXN59_RS11895	COG2116	formate transmembrane transporter activity
FXN59_RS11900	COG0537	adenosine 5'-monophosphoramidase activity
FXN59_RS11935	COG3022	response to hydroperoxide
FXN59_RS11940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FXN59_RS11955	COG0681	Belongs to the peptidase S26 family