locus-tag	class	description
AANUM_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AANUM_RS00010	COG0592	DNA-directed DNA polymerase activity
AANUM_RS00020	COG2226	methyltransferase
AANUM_RS00030	COG2081	HI0933 family
AANUM_RS00035	COG3088	subunit of a heme lyase
AANUM_RS00035	COG4235	cytochrome complex assembly
AANUM_RS00040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AANUM_RS00045	COG1138	Cytochrome C-type biogenesis protein
AANUM_RS00050	COG3301	Polysulphide reductase, NrfD
AANUM_RS00055	COG0437	4 iron, 4 sulfur cluster binding
AANUM_RS00060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AANUM_RS00095	COG1138	Cytochrome C-type biogenesis protein
AANUM_RS00105	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AANUM_RS00115	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AANUM_RS00120	COG4133	protoheme IX ABC transporter activity
AANUM_RS00125	COG2814	Major facilitator Superfamily
AANUM_RS00180	COG2267	carboxylic ester hydrolase activity
AANUM_RS00185	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AANUM_RS00195	COG0436	Aminotransferase
AANUM_RS00210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AANUM_RS00215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AANUM_RS00220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AANUM_RS00230	COG1652	LysM domain
AANUM_RS00235	COG2321	neutral zinc metallopeptidase
AANUM_RS00250	COG0280	phosphate acetyltransferase
AANUM_RS00250	COG0281	malic enzyme
AANUM_RS00285	COG3091	SprT-like family
AANUM_RS00290	COG0814	amino acid
AANUM_RS00295	COG1760	l-serine dehydratase
AANUM_RS00300	COG0252	asparaginase activity
AANUM_RS00310	COG3063	Type IV pilus biogenesis stability protein PilW
AANUM_RS00315	COG1426	Protein conserved in bacteria
AANUM_RS00330	COG2976	Protein conserved in bacteria
AANUM_RS00340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AANUM_RS00345	COG2233	PERMEase
AANUM_RS00350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AANUM_RS00355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AANUM_RS00360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AANUM_RS00370	COG0659	secondary active sulfate transmembrane transporter activity
AANUM_RS00390	COG2186	Transcriptional regulator
AANUM_RS00405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AANUM_RS00415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AANUM_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
AANUM_RS00430	COG0800	Aldolase
AANUM_RS00435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AANUM_RS00440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AANUM_RS00445	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AANUM_RS00450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AANUM_RS00460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AANUM_RS00465	COG1555	photosystem II stabilization
AANUM_RS00475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AANUM_RS00490	COG0196	riboflavin kinase activity
AANUM_RS00495	COG0728	peptidoglycan biosynthetic process
AANUM_RS00510	COG0560	Phosphoserine phosphatase
AANUM_RS00520	COG0193	aminoacyl-tRNA hydrolase activity
AANUM_RS00525	COG0012	GTP binding
AANUM_RS00530	COG1573	uracil-dna glycosylase
AANUM_RS00535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AANUM_RS00545	COG3115	cell septum assembly
AANUM_RS00565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AANUM_RS00570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AANUM_RS00590	COG0582	viral genome integration into host DNA
AANUM_RS00610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AANUM_RS00615	COG0255	Belongs to the universal ribosomal protein uL29 family
AANUM_RS00620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AANUM_RS00625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AANUM_RS00630	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AANUM_RS00635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AANUM_RS00640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AANUM_RS00645	COG0089	rRNA binding
AANUM_RS00655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AANUM_RS00660	COG0051	transcription antitermination factor activity, RNA binding
AANUM_RS00665	COG0583	DNA-binding transcription factor activity
AANUM_RS00670	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AANUM_RS00675	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AANUM_RS00680	COG2031	fatty acid transporter
AANUM_RS00685	COG0183	Belongs to the thiolase family
AANUM_RS00695	COG1288	antiporter activity
AANUM_RS00700	COG0549	Belongs to the carbamate kinase family
AANUM_RS00705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AANUM_RS00710	COG0038	chloride channel
AANUM_RS00715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AANUM_RS00725	COG1522	sequence-specific DNA binding
AANUM_RS00730	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AANUM_RS00740	COG1393	Belongs to the ArsC family
AANUM_RS00750	COG3036	rescue of stalled ribosome
AANUM_RS00755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AANUM_RS00760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AANUM_RS00780	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AANUM_RS00790	COG0569	domain protein
AANUM_RS00795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AANUM_RS00795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AANUM_RS00840	COG3161	chorismate lyase activity
AANUM_RS00850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AANUM_RS00855	COG1758	RNA polymerase activity
AANUM_RS00865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AANUM_RS00885	COG2801	Transposase and inactivated derivatives
AANUM_RS00895	COG3293	Transposase
AANUM_RS00910	COG2271	Major facilitator Superfamily
AANUM_RS00920	COG1215	transferase activity, transferring glycosyl groups
AANUM_RS00940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AANUM_RS00945	COG0561	phosphatase activity
AANUM_RS00950	COG3716	PTS system mannose fructose sorbose family IID component
AANUM_RS00955	COG3715	PTS system
AANUM_RS00960	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AANUM_RS00960	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AANUM_RS00965	COG0742	ribosomal rna small subunit methyltransferase
AANUM_RS00970	COG0552	protein localization to endoplasmic reticulum
AANUM_RS00975	COG2884	Cell division ATP-binding protein ftsE
AANUM_RS00980	COG2177	Part of the ABC transporter FtsEX involved in
AANUM_RS01040	COG0459	protein refolding
AANUM_RS01045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AANUM_RS01055	COG1027	Aspartate ammonia-lyase
AANUM_RS01060	COG0859	PFAM glycosyl transferase family 9
AANUM_RS01065	COG3716	PTS system mannose fructose sorbose family IID component
AANUM_RS01070	COG3715	PTS system
AANUM_RS01075	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AANUM_RS01075	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AANUM_RS01080	COG2814	Major facilitator Superfamily
AANUM_RS01085	COG1609	Transcriptional regulator
AANUM_RS01085	COG2207	Transcriptional regulator
AANUM_RS01090	COG1757	Na H antiporter
AANUM_RS01095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AANUM_RS01110	COG1129	ABC transporter
AANUM_RS01115	COG4213	ABC transporter substrate-binding protein
AANUM_RS01120	COG2115	Belongs to the xylose isomerase family
AANUM_RS01140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AANUM_RS01150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AANUM_RS01155	COG3850	Histidine kinase
AANUM_RS01160	COG3062	negative regulation of establishment of protein localization
AANUM_RS01165	COG0243	molybdopterin cofactor binding
AANUM_RS01170	COG0437	4 iron, 4 sulfur cluster binding
AANUM_RS01175	COG0348	domain, Protein
AANUM_RS01180	COG3043	anaerobic respiration
AANUM_RS01185	COG3005	denitrification pathway
AANUM_RS01190	COG0754	glutathionylspermidine amidase activity
AANUM_RS01195	COG0859	PFAM glycosyl transferase family 9
AANUM_RS01205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AANUM_RS01215	COG0737	Belongs to the 5'-nucleotidase family
AANUM_RS01240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AANUM_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
AANUM_RS01255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AANUM_RS01310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AANUM_RS01335	COG1011	Hydrolase
AANUM_RS01345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AANUM_RS01350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AANUM_RS01370	COG1596	polysaccharide export
AANUM_RS01370	COG1555	photosystem II stabilization
AANUM_RS01375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AANUM_RS01380	COG0561	phosphatase activity
AANUM_RS01385	COG1040	competence protein
AANUM_RS01400	COG1114	Component of the transport system for branched-chain amino acids
AANUM_RS01420	COG4804	nuclease activity
AANUM_RS01430	COG4545	Glutaredoxin-related protein
AANUM_RS01445	COG3381	protein complex oligomerization
AANUM_RS01450	COG3302	dmso reductase anchor subunit
AANUM_RS01460	COG0243	molybdopterin cofactor binding
AANUM_RS01480	COG5645	(Lipo)protein
AANUM_RS01485	COG0210	DNA helicase
AANUM_RS01510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AANUM_RS01515	COG0110	maltose O-acetyltransferase activity
AANUM_RS01520	COG1238	metal cluster binding
AANUM_RS01575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AANUM_RS01580	COG3610	response to peptide
AANUM_RS01585	COG2966	Psort location CytoplasmicMembrane, score
AANUM_RS01600	COG0545	Peptidyl-prolyl cis-trans isomerase
AANUM_RS01605	COG0688	phosphatidylethanolamine metabolic process
AANUM_RS01610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AANUM_RS01620	COG2830	Protein of unknown function (DUF452)
AANUM_RS01625	COG0500	methyltransferase
AANUM_RS01635	COG1399	metal-binding, possibly nucleic acid-binding protein
AANUM_RS01645	COG0416	fatty acid biosynthetic process
AANUM_RS01655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AANUM_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
AANUM_RS01670	COG2814	Major facilitator Superfamily
AANUM_RS01675	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AANUM_RS01680	COG0513	Belongs to the DEAD box helicase family
AANUM_RS01685	COG0799	negative regulation of ribosome biogenesis
AANUM_RS01695	COG0768	penicillin binding
AANUM_RS01700	COG0772	Belongs to the SEDS family
AANUM_RS01705	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AANUM_RS01705	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AANUM_RS01710	COG1686	Belongs to the peptidase S11 family
AANUM_RS01735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AANUM_RS01740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AANUM_RS01745	COG0765	amino acid transport
AANUM_RS01750	COG1126	abc transporter atp-binding protein
AANUM_RS01755	COG2168	tRNA wobble position uridine thiolation
AANUM_RS01765	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AANUM_RS01770	COG2964	Protein conserved in bacteria
AANUM_RS01775	COG0545	Peptidyl-prolyl cis-trans isomerase
AANUM_RS01785	COG0678	peroxiredoxin activity
AANUM_RS01785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AANUM_RS01790	COG0583	DNA-binding transcription factor activity
AANUM_RS01795	COG1309	transcriptional regulator
AANUM_RS01800	COG1132	(ABC) transporter
AANUM_RS01805	COG4988	ABC transporter
AANUM_RS01810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AANUM_RS01815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AANUM_RS01820	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AANUM_RS01830	COG1045	serine acetyltransferase
AANUM_RS01835	COG1494	fructose-1,6-bisphosphatase
AANUM_RS01845	COG0716	FMN binding
AANUM_RS01855	COG0702	epimerase
AANUM_RS01860	COG1733	regulation of RNA biosynthetic process
AANUM_RS01890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AANUM_RS01900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AANUM_RS01915	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AANUM_RS01920	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AANUM_RS01930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AANUM_RS01940	COG1349	DNA-binding transcription factor activity
AANUM_RS01970	COG3501	Rhs element vgr protein
AANUM_RS02025	COG1720	tRNA m6t6A37 methyltransferase activity
AANUM_RS02030	COG1575	Belongs to the MenA family. Type 1 subfamily
AANUM_RS02040	COG0471	metal ion transport
AANUM_RS02045	COG3028	Belongs to the UPF0307 family
AANUM_RS02050	COG0312	modulator of DNA gyrase
AANUM_RS02055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AANUM_RS02060	COG1929	Belongs to the glycerate kinase type-1 family
AANUM_RS02065	COG2610	gluconate transmembrane transporter activity
AANUM_RS02070	COG3835	regulator
AANUM_RS02080	COG0513	Belongs to the DEAD box helicase family
AANUM_RS02085	COG4785	May be involved in cell division
AANUM_RS02095	COG2731	YhcH YjgK YiaL family protein
AANUM_RS02100	COG3023	N-Acetylmuramoyl-L-alanine amidase
AANUM_RS02105	COG4969	Belongs to the N-Me-Phe pilin family
AANUM_RS02110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AANUM_RS02115	COG1459	type II secretion system
AANUM_RS02145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AANUM_RS02150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AANUM_RS02155	COG0805	protein transport
AANUM_RS02180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AANUM_RS02190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AANUM_RS02200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AANUM_RS02220	COG0201	protein transport
AANUM_RS02235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AANUM_RS02250	COG0814	amino acid
AANUM_RS02255	COG2129	metallophosphoesterase
AANUM_RS02265	COG2960	long-chain fatty acid transporting porin activity
AANUM_RS02280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AANUM_RS02285	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AANUM_RS02345	COG0513	Belongs to the DEAD box helicase family
AANUM_RS02355	COG3201	nicotinamide mononucleotide transporter
AANUM_RS02370	COG3078	GTPase activator activity
AANUM_RS02380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AANUM_RS02395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AANUM_RS02420	COG0511	ligase activity, forming carbon-carbon bonds
AANUM_RS02425	COG0439	Biotin carboxylase
AANUM_RS02435	COG4783	chaperone-mediated protein folding
AANUM_RS02440	COG3924	membrane
AANUM_RS02445	COG4145	pantothenate transmembrane transporter activity
AANUM_RS02450	COG2184	nucleotidyltransferase activity
AANUM_RS02475	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AANUM_RS02480	COG1115	amino acid carrier protein
AANUM_RS02490	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AANUM_RS02495	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AANUM_RS02495	COG0237	dephospho-CoA kinase activity
AANUM_RS02500	COG2801	Transposase and inactivated derivatives
AANUM_RS02530	COG2918	glutathione biosynthetic process
AANUM_RS02530	COG1181	Belongs to the D-alanine--D-alanine ligase family
AANUM_RS02535	COG2194	sulfuric ester hydrolase activity
AANUM_RS02540	COG0740	serine-type endopeptidase activity
AANUM_RS02560	COG3739	integral membrane protein
AANUM_RS02565	COG2217	Heavy metal translocating P-type atpase
AANUM_RS02570	COG2608	mercury ion transmembrane transporter activity
AANUM_RS02590	COG2932	Transcriptional regulator
AANUM_RS02610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AANUM_RS02630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AANUM_RS02670	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AANUM_RS02675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AANUM_RS02680	COG1011	Hydrolase
AANUM_RS02685	COG0494	nUDIX hydrolase
AANUM_RS02690	COG4977	sequence-specific DNA binding
AANUM_RS02690	COG1917	Cupin 2, conserved barrel domain protein
AANUM_RS02695	COG3059	membrane
AANUM_RS02700	COG1297	OPT oligopeptide transporter protein
AANUM_RS02710	COG1218	3'(2'),5'-bisphosphate nucleotidase
AANUM_RS02715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AANUM_RS02720	COG0363	glucosamine-6-phosphate deaminase activity
AANUM_RS02740	COG0762	integral membrane protein
AANUM_RS02750	COG0778	Nitroreductase
AANUM_RS02775	COG1496	oxidoreductase activity
AANUM_RS02790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AANUM_RS02810	COG0006	proline dipeptidase activity
AANUM_RS02835	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AANUM_RS02840	COG1792	Involved in formation and maintenance of cell shape
AANUM_RS02845	COG1077	Cell shape determining protein MreB Mrl
AANUM_RS02850	COG0557	exoribonuclease II activity
AANUM_RS02860	COG2271	Major facilitator Superfamily
AANUM_RS02865	COG0584	glycerophosphoryl diester phosphodiesterase
AANUM_RS02870	COG0758	DNA mediated transformation
AANUM_RS02905	COG1132	(ABC) transporter
AANUM_RS02910	COG1917	Cupin 2, conserved barrel domain protein
AANUM_RS02910	COG4977	sequence-specific DNA binding
AANUM_RS02915	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AANUM_RS02920	COG0859	PFAM glycosyl transferase family 9
AANUM_RS02935	COG1519	Transferase
AANUM_RS02940	COG0463	Glycosyl transferase, family 2
AANUM_RS02955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AANUM_RS02960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AANUM_RS02965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AANUM_RS02970	COG3719	Belongs to the RNase T2 family
AANUM_RS02980	COG0191	fructose-bisphosphate aldolase activity
AANUM_RS02985	COG3307	-O-antigen
AANUM_RS02990	COG2267	carboxylic ester hydrolase activity
AANUM_RS02995	COG0561	phosphatase activity
AANUM_RS03005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AANUM_RS03020	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AANUM_RS03030	COG0583	DNA-binding transcription factor activity
AANUM_RS03035	COG2962	Rard protein
AANUM_RS03050	COG0551	DNA topoisomerase type I activity
AANUM_RS03075	COG0705	Rhomboid family
AANUM_RS03080	COG1349	DNA-binding transcription factor activity
AANUM_RS03090	COG4178	(ABC) transporter
AANUM_RS03105	COG0233	cytoplasmic translational termination
AANUM_RS03120	COG0575	Belongs to the CDS family
AANUM_RS03135	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AANUM_RS03165	COG0471	metal ion transport
AANUM_RS03165	COG0490	domain, Protein
AANUM_RS03170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AANUM_RS03180	COG4589	Belongs to the CDS family
AANUM_RS03185	COG0521	Mo-molybdopterin cofactor biosynthetic process
AANUM_RS03245	COG3276	selenocysteine insertion sequence binding
AANUM_RS03250	COG1921	L-seryl-tRNASec selenium transferase activity
AANUM_RS03255	COG0442	prolyl-tRNA aminoacylation
AANUM_RS03270	COG1595	DNA-templated transcription, initiation
AANUM_RS03275	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AANUM_RS03280	COG3026	antisigma factor binding
AANUM_RS03285	COG3086	response to oxidative stress
AANUM_RS03290	COG1763	Mo-molybdopterin cofactor biosynthetic process
AANUM_RS03295	COG0300	oxidoreductase activity
AANUM_RS03300	COG2195	Cleaves the N-terminal amino acid of tripeptides
AANUM_RS03310	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AANUM_RS03315	COG2818	Glycosylase
AANUM_RS03320	COG3477	response to acidic pH
AANUM_RS03325	COG0019	diaminopimelate decarboxylase activity
AANUM_RS03335	COG0514	ATP-dependent DNA helicase (RecQ)
AANUM_RS03340	COG0187	DNA topoisomerase II activity
AANUM_RS03345	COG1072	(Pantothenic acid kinase))
AANUM_RS03375	COG1879	ABC-type sugar transport system periplasmic component
AANUM_RS03380	COG1129	ABC transporter
AANUM_RS03385	COG1172	Belongs to the binding-protein-dependent transport system permease family
AANUM_RS03410	COG0583	DNA-binding transcription factor activity
AANUM_RS03415	COG0471	metal ion transport
AANUM_RS03425	COG2183	response to ionizing radiation
AANUM_RS03430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AANUM_RS03440	COG1595	DNA-templated transcription, initiation
AANUM_RS03450	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AANUM_RS03455	COG3071	HemY protein
AANUM_RS03460	COG2959	enzyme of heme biosynthesis
AANUM_RS03470	COG0181	hydroxymethylbilane synthase activity
AANUM_RS03480	COG2197	response regulator
AANUM_RS03485	COG0729	surface antigen
AANUM_RS03490	COG2911	Protein conserved in bacteria
AANUM_RS03495	COG0248	Ppx GppA phosphatase
AANUM_RS03515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AANUM_RS03520	COG3068	Protein conserved in bacteria
AANUM_RS03530	COG1349	DNA-binding transcription factor activity
AANUM_RS03535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AANUM_RS03555	COG2272	Belongs to the type-B carboxylesterase lipase family
AANUM_RS03560	COG0667	Aldo Keto reductase
AANUM_RS03565	COG0656	L-ascorbic acid biosynthetic process
AANUM_RS03580	COG0433	COG0433 Predicted ATPase
AANUM_RS03585	COG2258	MOSC domain
AANUM_RS03590	COG3012	SEC-C Motif Domain Protein
AANUM_RS03600	COG1490	D-aminoacyl-tRNA deacylase activity
AANUM_RS03605	COG0786	glutamate:sodium symporter activity
AANUM_RS03610	COG2205	protein histidine kinase activity
AANUM_RS03615	COG0745	RESPONSE REGULATOR receiver
AANUM_RS03620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AANUM_RS03630	COG3082	Protein of unknown function (DUF1414)
AANUM_RS03635	COG3083	sulfuric ester hydrolase activity
AANUM_RS03640	COG0402	S-adenosylhomocysteine deaminase activity
AANUM_RS03645	COG3956	TIGRFAM MazG family protein
AANUM_RS03660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AANUM_RS03670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AANUM_RS03675	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AANUM_RS03680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AANUM_RS03695	COG0148	phosphopyruvate hydratase activity
AANUM_RS03705	COG2991	Protein conserved in bacteria
AANUM_RS03710	COG1477	protein flavinylation
AANUM_RS03715	COG2871	sodium ion transport
AANUM_RS03720	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AANUM_RS03725	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AANUM_RS03730	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AANUM_RS03745	COG0271	Belongs to the BolA IbaG family
AANUM_RS03750	COG3056	Lipoprotein
AANUM_RS03775	COG1194	a g-specific adenine glycosylase
AANUM_RS03785	COG3171	Protein conserved in bacteria
AANUM_RS03790	COG1840	ABC-type Fe3 transport system, periplasmic component
AANUM_RS03795	COG1178	ABC-type Fe3 transport system permease component
AANUM_RS03800	COG3842	ATPase activity
AANUM_RS03815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AANUM_RS03825	COG1561	YicC-like family, N-terminal region
AANUM_RS03830	COG0354	folic acid binding
AANUM_RS03845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AANUM_RS03850	COG1381	Involved in DNA repair and RecF pathway recombination
AANUM_RS03855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AANUM_RS03860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AANUM_RS03865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AANUM_RS03875	COG0500	methyltransferase
AANUM_RS03880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AANUM_RS03885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AANUM_RS03890	COG1309	transcriptional regulator
AANUM_RS03895	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AANUM_RS03900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AANUM_RS03915	COG3306	glycosyltransferase involved in LPS biosynthesis
AANUM_RS03925	COG3306	glycosyltransferase involved in LPS biosynthesis
AANUM_RS03960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AANUM_RS03970	COG1309	transcriptional regulator
AANUM_RS03985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AANUM_RS03990	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AANUM_RS03995	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AANUM_RS04000	COG4972	Pilus assembly protein
AANUM_RS04020	COG4796	Type ii and iii secretion system protein
AANUM_RS04035	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AANUM_RS04065	COG0653	protein targeting
AANUM_RS04080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AANUM_RS04095	COG0789	Transcriptional regulator
AANUM_RS04100	COG4701	Protein of unknown function (DUF721)
AANUM_RS04115	COG0494	nUDIX hydrolase
AANUM_RS04120	COG1466	dna polymerase III delta subunit
AANUM_RS04125	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AANUM_RS04140	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AANUM_RS04145	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AANUM_RS04150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AANUM_RS04155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AANUM_RS04160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AANUM_RS04180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AANUM_RS04185	COG4221	oxidoreductase activity
AANUM_RS04190	COG0789	Transcriptional regulator
AANUM_RS04195	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AANUM_RS04210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AANUM_RS04220	COG4536	flavin adenine dinucleotide binding
AANUM_RS04225	COG0811	peptide transport
AANUM_RS04230	COG0848	biopolymer transport protein
AANUM_RS04240	COG4783	chaperone-mediated protein folding
AANUM_RS04250	COG0814	amino acid
AANUM_RS04280	COG2853	Lipoprotein
AANUM_RS04290	COG3501	Rhs element vgr protein
AANUM_RS04355	COG3561	AntA/AntB antirepressor
AANUM_RS04400	COG0582	viral genome integration into host DNA
AANUM_RS04420	COG2095	MarC family integral membrane protein
AANUM_RS04425	COG0488	(ABC) transporter
AANUM_RS04430	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AANUM_RS04435	COG2137	regulation of response to DNA damage stimulus
AANUM_RS04440	COG0251	oxidation-reduction process
AANUM_RS04450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AANUM_RS04475	COG2826	transposase and inactivated derivatives, IS30 family
AANUM_RS04480	COG1285	pathogenesis
AANUM_RS04490	COG0733	neurotransmitter:sodium symporter activity
AANUM_RS04495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AANUM_RS04510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AANUM_RS04540	COG1238	metal cluster binding
AANUM_RS04550	COG1388	LysM domain
AANUM_RS04550	COG4942	peptidase
AANUM_RS04570	COG0105	UTP biosynthetic process
AANUM_RS04590	COG4535	Mg2 and Co2 transporter CorC
AANUM_RS04595	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AANUM_RS04605	COG2301	Belongs to the HpcH HpaI aldolase family
AANUM_RS04610	COG3051	citrate lyase alpha subunit
AANUM_RS04615	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
AANUM_RS04615	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AANUM_RS04620	COG0471	metal ion transport
AANUM_RS04635	COG2017	converts alpha-aldose to the beta-anomer
AANUM_RS04645	COG1085	galactose-1-phosphate uridylyltransferase
AANUM_RS04650	COG1609	Transcriptional regulator
AANUM_RS04655	COG1879	ABC-type sugar transport system periplasmic component
AANUM_RS04665	COG4211	Belongs to the binding-protein-dependent transport system permease family
AANUM_RS04670	COG0784	Response regulator, receiver
AANUM_RS04670	COG2198	Histidine kinase
AANUM_RS04670	COG5002	protein histidine kinase activity
AANUM_RS04675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AANUM_RS04680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AANUM_RS04680	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AANUM_RS04700	COG0497	DNA recombination
AANUM_RS04705	COG3047	cAMP biosynthetic process
AANUM_RS04720	COG1607	acyl-coa hydrolase
AANUM_RS04725	COG2350	Protein conserved in bacteria
AANUM_RS04730	COG0741	lytic transglycosylase activity
AANUM_RS04755	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AANUM_RS04760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AANUM_RS04765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AANUM_RS04775	COG1408	metallophosphoesterase
AANUM_RS04780	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AANUM_RS04785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AANUM_RS04790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AANUM_RS04795	COG1120	ATPase activity
AANUM_RS04805	COG1053	succinate dehydrogenase
AANUM_RS04810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AANUM_RS04820	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AANUM_RS04855	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AANUM_RS04860	COG0494	nUDIX hydrolase
AANUM_RS04865	COG1876	peptidase activity
AANUM_RS04875	COG1393	Belongs to the ArsC family
AANUM_RS04880	COG0326	Molecular chaperone. Has ATPase activity
AANUM_RS04885	COG1605	Chorismate mutase
AANUM_RS04885	COG0077	Prephenate dehydratase
AANUM_RS04895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AANUM_RS04900	COG0849	cell division
AANUM_RS04905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AANUM_RS04920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AANUM_RS04950	COG0768	penicillin binding
AANUM_RS04955	COG3116	cell division
AANUM_RS04970	COG1966	Carbon starvation protein
AANUM_RS04975	COG4160	amino acid transport
AANUM_RS04980	COG4215	(ABC) transporter
AANUM_RS04985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AANUM_RS04990	COG1126	abc transporter atp-binding protein
AANUM_RS05000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AANUM_RS05010	COG1444	tRNA N-acetyltransferase activity
AANUM_RS05020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AANUM_RS05040	COG4964	Belongs to the GSP D family
AANUM_RS05110	COG2826	transposase and inactivated derivatives, IS30 family
AANUM_RS05150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AANUM_RS05150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AANUM_RS05150	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AANUM_RS05155	COG1105	Belongs to the carbohydrate kinase PfkB family
AANUM_RS05160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AANUM_RS05160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AANUM_RS05170	COG0746	molybdenum cofactor guanylyltransferase activity
AANUM_RS05175	COG3084	Protein conserved in bacteria
AANUM_RS05180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AANUM_RS05185	COG3085	chromosome segregation
AANUM_RS05235	COG0561	phosphatase activity
AANUM_RS05245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AANUM_RS05255	COG2610	gluconate transmembrane transporter activity
AANUM_RS05260	COG3622	Belongs to the hyi family
AANUM_RS05265	COG0235	Class ii aldolase
AANUM_RS05270	COG3395	kinase activity
AANUM_RS05275	COG2084	Dehydrogenase
AANUM_RS05285	COG0347	Belongs to the P(II) protein family
AANUM_RS05290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AANUM_RS05295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AANUM_RS05300	COG0470	DNA polymerase III
AANUM_RS05305	COG0084	hydrolase, TatD family'
AANUM_RS05315	COG1253	flavin adenine dinucleotide binding
AANUM_RS05345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AANUM_RS05350	COG4942	peptidase
AANUM_RS05355	COG2861	carbohydrate metabolic process
AANUM_RS05360	COG0606	chelatase, subunit chli
AANUM_RS05370	COG2990	Protein conserved in bacteria
AANUM_RS05375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AANUM_RS05395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AANUM_RS05455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AANUM_RS05465	COG0084	hydrolase, TatD family'
AANUM_RS05470	COG0602	queuosine metabolic process
AANUM_RS05475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AANUM_RS05475	COG1328	CTP reductase activity
AANUM_RS05485	COG1022	Amp-dependent synthetase and ligase
AANUM_RS05490	COG0587	DNA-directed DNA polymerase activity
AANUM_RS05510	COG0753	catalase activity
AANUM_RS05515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AANUM_RS05520	COG0165	Argininosuccinate lyase
AANUM_RS05550	COG0582	viral genome integration into host DNA
AANUM_RS05645	COG3561	AntA/AntB antirepressor
AANUM_RS05680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AANUM_RS05715	COG3179	chitinase
AANUM_RS05735	COG3728	DNA packaging
AANUM_RS05745	COG3567	Phage-associated protein, HI1409 family
AANUM_RS05750	COG2369	cell adhesion
AANUM_RS05760	COG3566	protein conserved in bacteria
AANUM_RS05765	COG3566	protein conserved in bacteria
AANUM_RS05880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AANUM_RS05885	COG1879	ABC-type sugar transport system periplasmic component
AANUM_RS05890	COG1172	Belongs to the binding-protein-dependent transport system permease family
AANUM_RS05900	COG1869	D-ribose catabolic process
AANUM_RS05910	COG0730	response to heat
AANUM_RS05925	COG0590	tRNA wobble adenosine to inosine editing
AANUM_RS05955	COG3501	Rhs element vgr protein
AANUM_RS05960	COG0489	protein tyrosine kinase activity
AANUM_RS05965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AANUM_RS05965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AANUM_RS05970	COG2975	iron-sulfur cluster assembly
AANUM_RS05975	COG0633	Ferredoxin
AANUM_RS05980	COG0443	Heat shock 70 kDa protein
AANUM_RS05995	COG0822	iron-sulfur transferase activity
AANUM_RS06005	COG1959	2 iron, 2 sulfur cluster binding
AANUM_RS06010	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AANUM_RS06070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AANUM_RS06085	COG1530	ribonuclease E activity
AANUM_RS06095	COG2259	Doxx family
AANUM_RS06105	COG1611	Belongs to the LOG family
AANUM_RS06115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AANUM_RS06120	COG0745	RESPONSE REGULATOR receiver
AANUM_RS06125	COG4608	Belongs to the ABC transporter superfamily
AANUM_RS06130	COG0444	Belongs to the ABC transporter superfamily
AANUM_RS06135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AANUM_RS06140	COG0601	transmembrane transport
AANUM_RS06145	COG0601	transmembrane transport
AANUM_RS06150	COG4166	transmembrane transport
AANUM_RS06160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AANUM_RS06165	COG0697	spore germination
AANUM_RS06170	COG0697	spore germination
AANUM_RS06185	COG0142	geranyltranstransferase activity
AANUM_RS06190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AANUM_RS06205	COG2056	Na+-H+ antiporter family
AANUM_RS06210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AANUM_RS06215	COG0346	lactoylglutathione lyase activity
AANUM_RS06225	COG2271	Major facilitator Superfamily
AANUM_RS06240	COG1755	Isoprenylcysteine carboxyl methyltransferase
AANUM_RS06245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AANUM_RS06265	COG0494	nUDIX hydrolase
AANUM_RS06270	COG0217	transcriptional regulatory protein
AANUM_RS06300	COG1271	oxidase subunit
AANUM_RS06305	COG1294	oxidase, subunit
AANUM_RS06315	COG0824	Thioesterase
AANUM_RS06320	COG0811	peptide transport
AANUM_RS06325	COG0848	biopolymer transport protein
AANUM_RS06330	COG3064	Membrane
AANUM_RS06360	COG2165	general secretion pathway protein
AANUM_RS06365	COG4795	General secretion pathway protein
AANUM_RS06380	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AANUM_RS06385	COG0456	acetyltransferase
AANUM_RS06390	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
AANUM_RS06395	COG2813	Specifically methylates the guanine in position
AANUM_RS06410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AANUM_RS06420	COG2994	toxin metabolic process
AANUM_RS06425	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AANUM_RS06430	COG2274	protein secretion by the type I secretion system
AANUM_RS06435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AANUM_RS06445	COG0246	Mannitol dehydrogenase
AANUM_RS06450	COG3722	fumarate hydratase activity
AANUM_RS06455	COG0673	inositol 2-dehydrogenase activity
AANUM_RS06465	COG3962	Belongs to the TPP enzyme family
AANUM_RS06470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AANUM_RS06510	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AANUM_RS06535	COG3623	hexulose-6-phosphate isomerase
AANUM_RS06540	COG0235	Class ii aldolase
AANUM_RS06575	COG0814	amino acid
AANUM_RS06590	COG0778	Nitroreductase
AANUM_RS06600	COG2268	Band 7 protein
AANUM_RS06605	COG0114	fumarate hydratase activity
AANUM_RS06610	COG2927	DNA polymerase III (CHI subunit)
AANUM_RS06640	COG3550	peptidyl-serine autophosphorylation
AANUM_RS06650	COG2814	Major facilitator Superfamily
AANUM_RS06670	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AANUM_RS06680	COG0602	queuosine metabolic process
AANUM_RS06685	COG0720	synthase
AANUM_RS06725	COG0673	inositol 2-dehydrogenase activity
AANUM_RS06745	COG1172	Belongs to the binding-protein-dependent transport system permease family
AANUM_RS06750	COG1012	belongs to the aldehyde dehydrogenase family
AANUM_RS06750	COG1454	alcohol dehydrogenase
AANUM_RS06760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AANUM_RS06765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AANUM_RS06770	COG1862	Preprotein translocase
AANUM_RS06780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AANUM_RS06825	COG0826	peptidase U32
AANUM_RS06840	COG2026	Addiction module toxin, RelE StbE family
AANUM_RS06860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AANUM_RS06865	COG0328	RNA-DNA hybrid ribonuclease activity
AANUM_RS06875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AANUM_RS06895	COG1620	l-lactate permease
AANUM_RS06910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AANUM_RS06915	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AANUM_RS06920	COG0617	tRNA 3'-terminal CCA addition
AANUM_RS06925	COG4991	sh3 domain protein
AANUM_RS06930	COG0306	phosphate transporter
AANUM_RS06935	COG1392	Phosphate transport regulator
AANUM_RS06940	COG3025	triphosphatase activity
AANUM_RS06945	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AANUM_RS06950	COG2963	transposase activity
AANUM_RS06955	COG0563	adenylate kinase activity
AANUM_RS06965	COG0375	protein maturation
AANUM_RS06970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AANUM_RS06975	COG3152	Membrane
AANUM_RS06980	COG2252	PERMEase
AANUM_RS06995	COG0825	malonyl-CoA metabolic process
AANUM_RS07000	COG2351	hydroxyisourate hydrolase activity
AANUM_RS07015	COG3041	Addiction module toxin RelE StbE family
AANUM_RS07020	COG3077	Addiction module antitoxin, RelB DinJ family
AANUM_RS07025	COG3069	C4-dicarboxylate transmembrane transporter activity
AANUM_RS07035	COG2801	Transposase and inactivated derivatives
AANUM_RS07045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AANUM_RS07050	COG0785	Cytochrome C biogenesis protein
AANUM_RS07055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AANUM_RS07055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AANUM_RS07060	COG0288	reversible hydration of carbon dioxide
AANUM_RS07065	COG2823	Periplasmic or secreted lipoprotein
AANUM_RS07070	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AANUM_RS07075	COG0792	nuclease activity
AANUM_RS07085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AANUM_RS07105	COG0616	signal peptide processing
AANUM_RS07110	COG3047	cAMP biosynthetic process
AANUM_RS07110	COG2885	chlorophyll binding
AANUM_RS07115	COG0625	glutathione transferase activity
AANUM_RS07120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AANUM_RS07125	COG0187	DNA topoisomerase II activity
AANUM_RS07135	COG0488	(ABC) transporter
AANUM_RS07140	COG3683	transport system, periplasmic component
AANUM_RS07145	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AANUM_RS07165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AANUM_RS07170	COG3105	Protein conserved in bacteria
AANUM_RS07175	COG1944	ATP diphosphatase activity
AANUM_RS07185	COG3422	double-strand break repair
AANUM_RS07195	COG2226	methyltransferase
AANUM_RS07200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AANUM_RS07210	COG1846	Transcriptional regulator
AANUM_RS07210	COG1940	carbohydrate kinase activity
AANUM_RS07280	COG2190	(PTS) system
AANUM_RS07280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AANUM_RS07280	COG1263	PTS System
AANUM_RS07285	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
AANUM_RS07290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AANUM_RS07290	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AANUM_RS07295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AANUM_RS07300	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AANUM_RS07310	COG1737	Transcriptional regulator
AANUM_RS07315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AANUM_RS07320	COG0363	glucosamine-6-phosphate deaminase activity
AANUM_RS07325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AANUM_RS07330	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AANUM_RS07345	COG0277	FAD linked oxidase domain protein
AANUM_RS07345	COG0247	lactate metabolic process
AANUM_RS07365	COG2363	Small membrane protein
AANUM_RS07380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AANUM_RS07390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AANUM_RS07395	COG0577	efflux transmembrane transporter activity
AANUM_RS07395	COG1136	(ABC) transporter
AANUM_RS07405	COG1136	(ABC) transporter
AANUM_RS07405	COG0577	efflux transmembrane transporter activity
AANUM_RS07420	COG0672	)-iron permease
AANUM_RS07425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AANUM_RS07435	COG0316	Belongs to the HesB IscA family
AANUM_RS07440	COG0024	Methionine aminopeptidase
AANUM_RS07450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AANUM_RS07455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AANUM_RS07500	COG4172	Belongs to the ABC transporter superfamily
AANUM_RS07505	COG4172	Belongs to the ABC transporter superfamily
AANUM_RS07510	COG4172	Belongs to the ABC transporter superfamily
AANUM_RS07515	COG4171	peptide transport system, permease
AANUM_RS07520	COG4168	peptide transport system, permease
AANUM_RS07525	COG4166	transmembrane transport
AANUM_RS07530	COG3106	COG3106 Predicted ATPase
AANUM_RS07540	COG3283	Transcriptional regulator of aromatic amino acids metabolism
AANUM_RS07545	COG1923	regulation of RNA biosynthetic process
AANUM_RS07560	COG1388	LysM domain
AANUM_RS07560	COG0860	N-Acetylmuramoyl-L-alanine amidase
AANUM_RS07565	COG0802	atpase or kinase
AANUM_RS07575	COG2246	polysaccharide biosynthetic process
AANUM_RS07585	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AANUM_RS07595	COG2194	sulfuric ester hydrolase activity
AANUM_RS07630	COG2337	Toxic component of a toxin-antitoxin (TA) module
AANUM_RS07650	COG3021	interspecies interaction between organisms
AANUM_RS07725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AANUM_RS07730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AANUM_RS07735	COG2190	(PTS) system
AANUM_RS07740	COG0339	signal peptide processing
AANUM_RS07745	COG2832	Protein of unknown function (DUF454)
AANUM_RS07775	COG3501	Rhs element vgr protein
AANUM_RS07780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AANUM_RS07790	COG0512	Glutamine amidotransferase of anthranilate synthase
AANUM_RS07795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AANUM_RS07830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AANUM_RS07840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AANUM_RS07850	COG3684	Belongs to the aldolase LacD family
AANUM_RS07855	COG3775	system Galactitol-specific IIC component
AANUM_RS07860	COG1063	alcohol dehydrogenase
AANUM_RS07865	COG1349	DNA-binding transcription factor activity
AANUM_RS07875	COG0142	geranyltranstransferase activity
AANUM_RS07890	COG0285	dihydrofolate synthase activity
AANUM_RS07895	COG0406	alpha-ribazole phosphatase activity
AANUM_RS07900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AANUM_RS07905	COG2431	L-lysine efflux transmembrane transporter activity
AANUM_RS07910	COG0564	pseudouridine synthase activity
AANUM_RS07920	COG2824	Alkylphosphonate utilization operon protein PhnA
AANUM_RS07930	COG1538	Outer membrane efflux protein
AANUM_RS07935	COG0577	efflux transmembrane transporter activity
AANUM_RS07935	COG1136	(ABC) transporter
AANUM_RS07940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AANUM_RS07990	COG4591	ABC-type transport system involved in lipoprotein release permease component
AANUM_RS07995	COG1136	(ABC) transporter
AANUM_RS08000	COG4591	ABC-type transport system involved in lipoprotein release permease component
AANUM_RS08005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AANUM_RS08010	COG0305	Participates in initiation and elongation during chromosome replication
AANUM_RS08020	COG0166	Belongs to the GPI family
AANUM_RS08030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AANUM_RS08040	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AANUM_RS08045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AANUM_RS08050	COG1280	lysine exporter protein (LysE YggA)
AANUM_RS08060	COG0633	Ferredoxin
AANUM_RS08070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AANUM_RS08085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AANUM_RS08095	COG1840	ABC-type Fe3 transport system, periplasmic component
AANUM_RS08105	COG3842	ATPase activity
AANUM_RS08110	COG0366	Alpha amylase catalytic
AANUM_RS08115	COG3833	ABC-type maltose transport systems, permease component
AANUM_RS08125	COG2182	Extracellular solute-binding protein
AANUM_RS08130	COG3842	ATPase activity
AANUM_RS08135	COG4580	involved in the transport of maltose and maltodextrins
AANUM_RS08150	COG0676	glucose-6-phosphate 1-epimerase activity
AANUM_RS08155	COG1199	ATP-dependent helicase activity
AANUM_RS08160	COG1214	PFAM Peptidase M22, glycoprotease
AANUM_RS08165	COG3065	identical protein binding
AANUM_RS08170	COG0318	PFAM AMP-dependent synthetase and ligase
AANUM_RS08175	COG0318	PFAM AMP-dependent synthetase and ligase
AANUM_RS08180	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AANUM_RS08185	COG1858	cytochrome C peroxidase
AANUM_RS08210	COG0330	HflC and HflK could
AANUM_RS08220	COG2249	NAD(P)H dehydrogenase (quinone) activity
AANUM_RS08225	COG3381	protein complex oligomerization
AANUM_RS08230	COG1560	Kdo2-lipid A biosynthetic process
AANUM_RS08235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AANUM_RS08235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AANUM_RS08240	COG2166	iron-sulfur cluster assembly
AANUM_RS08245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AANUM_RS08250	COG1525	nuclease
AANUM_RS08265	COG4774	siderophore transport
AANUM_RS08275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AANUM_RS08280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AANUM_RS08285	COG1120	ATPase activity
AANUM_RS08305	COG3585	molybdate ion transport
AANUM_RS08315	COG1120	ATPase activity
AANUM_RS08320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AANUM_RS08335	COG3293	Transposase
AANUM_RS08345	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AANUM_RS08355	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AANUM_RS08360	COG0314	molybdopterin synthase activity
AANUM_RS08370	COG2969	positive regulation of protein catabolic process
AANUM_RS08380	COG1940	carbohydrate kinase activity
AANUM_RS08385	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AANUM_RS08390	COG1070	Carbohydrate kinase
AANUM_RS08395	COG2390	Transcriptional regulator
AANUM_RS08430	COG0469	pyruvate kinase activity
AANUM_RS08440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AANUM_RS08450	COG0133	tryptophan synthase activity
AANUM_RS08455	COG4221	oxidoreductase activity
AANUM_RS08465	COG1629	transport
AANUM_RS08465	COG4771	TonB-dependent receptor
AANUM_RS08470	COG4771	TonB-dependent receptor
AANUM_RS08470	COG1629	transport
AANUM_RS08485	COG3630	sodium ion export across plasma membrane
AANUM_RS08495	COG0298	carbon dioxide binding
AANUM_RS08505	COG0135	phosphoribosylanthranilate isomerase activity
AANUM_RS08505	COG0134	indole-3-glycerol-phosphate synthase activity
AANUM_RS08510	COG3093	addiction module antidote protein HigA
AANUM_RS08520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AANUM_RS08525	COG1942	4-Oxalocrotonate Tautomerase
AANUM_RS08530	COG0512	Glutamine amidotransferase of anthranilate synthase
AANUM_RS08535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AANUM_RS08540	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AANUM_RS08545	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AANUM_RS08545	COG0517	IMP dehydrogenase activity
AANUM_RS08560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AANUM_RS08575	COG0791	NLP P60 protein
AANUM_RS08595	COG1129	ABC transporter
AANUM_RS08595	COG0842	Transport permease protein
AANUM_RS08600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AANUM_RS08610	COG1448	Aminotransferase
AANUM_RS08615	COG0308	aminopeptidase N
AANUM_RS08620	COG0167	dihydroorotate dehydrogenase activity
AANUM_RS08625	COG0613	PHP domain protein
AANUM_RS08635	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
AANUM_RS08640	COG0589	response to stress
AANUM_RS08645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AANUM_RS08655	COG1528	Iron-storage protein
AANUM_RS08660	COG1528	Iron-storage protein
AANUM_RS08665	COG2925	Exonuclease
AANUM_RS08670	COG0697	spore germination
AANUM_RS08675	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AANUM_RS08680	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AANUM_RS08685	COG0318	PFAM AMP-dependent synthetase and ligase
AANUM_RS08685	COG0204	Acyl-transferase
AANUM_RS08690	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AANUM_RS08695	COG1686	Belongs to the peptidase S11 family
AANUM_RS08705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AANUM_RS08710	COG0586	Pfam SNARE associated Golgi protein
AANUM_RS08715	COG0058	SHG alpha-glucan phosphorylase activity
AANUM_RS08730	COG1523	belongs to the glycosyl hydrolase 13 family
AANUM_RS08765	COG0488	(ABC) transporter
AANUM_RS08770	COG3657	addiction module killer protein
AANUM_RS08785	COG1346	cytolysis
AANUM_RS08805	COG2826	transposase and inactivated derivatives, IS30 family
AANUM_RS08815	COG3293	Transposase
AANUM_RS08835	COG3005	denitrification pathway
AANUM_RS08840	COG0243	molybdopterin cofactor binding
AANUM_RS08845	COG2315	Protein conserved in bacteria
AANUM_RS08850	COG0471	metal ion transport
AANUM_RS08865	COG0101	tRNA pseudouridine synthase activity
AANUM_RS08885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AANUM_RS08890	COG1074	ATP-dependent DNA helicase activity
AANUM_RS08895	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AANUM_RS08905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AANUM_RS08910	COG1067	ATP-dependent peptidase activity
AANUM_RS08920	COG1278	Cold shock
AANUM_RS08925	COG3140	Belongs to the UPF0181 family
AANUM_RS08935	COG3098	single-species biofilm formation
AANUM_RS08940	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AANUM_RS08985	COG3842	ATPase activity
AANUM_RS08990	COG1178	ABC-type Fe3 transport system permease component
AANUM_RS08995	COG3842	ATPase activity
AANUM_RS09000	COG3101	peptidyl-lysine hydroxylation
AANUM_RS09005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AANUM_RS09015	COG0788	formyltetrahydrofolate deformylase activity
AANUM_RS09020	COG2916	Histone family protein nucleoid-structuring protein H-NS
AANUM_RS09025	COG1757	Na H antiporter
AANUM_RS09030	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AANUM_RS09040	COG0251	oxidation-reduction process
AANUM_RS09055	COG0463	Glycosyl transferase, family 2
AANUM_RS09065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AANUM_RS09075	COG1560	Kdo2-lipid A biosynthetic process
AANUM_RS09080	COG0730	response to heat
AANUM_RS09085	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AANUM_RS09090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AANUM_RS09095	COG3264	Mechanosensitive ion channel
AANUM_RS09095	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AANUM_RS09100	COG0318	PFAM AMP-dependent synthetase and ligase
AANUM_RS09105	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AANUM_RS09110	COG0596	Alpha beta hydrolase
AANUM_RS09115	COG0716	FMN binding
AANUM_RS09120	COG0735	belongs to the Fur family
AANUM_RS09130	COG3094	Invasion gene expression up-regulator, SirB
AANUM_RS09135	COG0023	Translation Initiation Factor
AANUM_RS09145	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AANUM_RS09150	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AANUM_RS09155	COG0776	regulation of translation
AANUM_RS09160	COG0539	negative regulation of cytoplasmic translation
AANUM_RS09170	COG2990	Protein conserved in bacteria
AANUM_RS09175	COG4771	TonB-dependent receptor
AANUM_RS09185	COG3423	Transcriptional regulator
AANUM_RS09190	COG2801	Transposase and inactivated derivatives
AANUM_RS09250	COG4382	Mu-like prophage protein Gp16
AANUM_RS09255	COG5566	PFAM Mor transcription activator
AANUM_RS09260	COG3023	N-Acetylmuramoyl-L-alanine amidase
AANUM_RS09290	COG0640	Transcriptional regulator
AANUM_RS09300	COG4373	Mu-like prophage FluMu protein gp28
AANUM_RS09305	COG4383	Mu-like prophage protein gp29
AANUM_RS09310	COG2369	cell adhesion
AANUM_RS09315	COG5005	Phage virion morphogenesis
AANUM_RS09320	COG4388	Caudovirus prohead serine protease
AANUM_RS09325	COG4397	Mu-like prophage major head subunit gpT
AANUM_RS09335	COG4387	Mu-like prophage protein GP36
AANUM_RS09340	COG5003	unkown
AANUM_RS09410	COG3392	D12 class N6 adenine-specific DNA methyltransferase
AANUM_RS09445	COG4771	TonB-dependent receptor
AANUM_RS09450	COG0612	Peptidase, M16
AANUM_RS09455	COG1687	branched-chain amino acid
AANUM_RS09460	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AANUM_RS09465	COG0583	DNA-binding transcription factor activity
AANUM_RS09475	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AANUM_RS09480	COG1518	maintenance of DNA repeat elements
AANUM_RS09525	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AANUM_RS09530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AANUM_RS09535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AANUM_RS09550	COG0405	Gamma-glutamyltransferase
AANUM_RS09560	COG0745	RESPONSE REGULATOR receiver
AANUM_RS09565	COG0745	RESPONSE REGULATOR receiver
AANUM_RS09580	COG0737	Belongs to the 5'-nucleotidase family
AANUM_RS09585	COG4607	ABC-type enterochelin transport system periplasmic component
AANUM_RS09590	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AANUM_RS09595	COG4605	iron ion homeostasis
AANUM_RS09600	COG4604	ABC transporter, ATP-binding protein
AANUM_RS09605	COG0739	heme binding
AANUM_RS09615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AANUM_RS09620	COG0733	neurotransmitter:sodium symporter activity
AANUM_RS09625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AANUM_RS09655	COG4657	Part of a membrane complex involved in electron transport
AANUM_RS09660	COG1090	epimerase
AANUM_RS09665	COG1438	arginine binding
AANUM_RS09670	COG0039	L-malate dehydrogenase activity
AANUM_RS09680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AANUM_RS09695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AANUM_RS09700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AANUM_RS09700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AANUM_RS09705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AANUM_RS09715	COG0471	metal ion transport
AANUM_RS09720	COG2005	Transcriptional regulator
AANUM_RS09725	COG0725	ABC transporter, periplasmic molybdate-binding protein
AANUM_RS09730	COG4149	molybdate abc transporter
AANUM_RS09735	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AANUM_RS09745	COG0795	lipopolysaccharide-transporting ATPase activity
AANUM_RS09750	COG0795	lipopolysaccharide-transporting ATPase activity
AANUM_RS09755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AANUM_RS09760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AANUM_RS09785	COG0309	Hydrogenase expression formation protein (HypE)
AANUM_RS09790	COG0409	Hydrogenase expression formation protein
AANUM_RS09795	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AANUM_RS09800	COG1122	ATPase activity
AANUM_RS09805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AANUM_RS09810	COG0310	cobalt ion transport
AANUM_RS09815	COG0310	cobalt ion transport
AANUM_RS09820	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
AANUM_RS09825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AANUM_RS09830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AANUM_RS09835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AANUM_RS09840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AANUM_RS09850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AANUM_RS09870	COG2271	Major facilitator Superfamily
AANUM_RS09880	COG3718	enzyme involved in inositol metabolism
AANUM_RS09900	COG3501	Rhs element vgr protein
AANUM_RS09910	COG2949	membrane
AANUM_RS09915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AANUM_RS09935	COG0583	DNA-binding transcription factor activity
AANUM_RS09945	COG0009	L-threonylcarbamoyladenylate synthase
AANUM_RS09950	COG1605	Chorismate mutase
AANUM_RS09950	COG0287	Prephenate dehydrogenase
AANUM_RS09955	COG0616	signal peptide processing
AANUM_RS09960	COG0778	Nitroreductase
AANUM_RS09965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AANUM_RS09970	COG0508	dehydrogenase complex catalyzes the overall conversion of
AANUM_RS09975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AANUM_RS09985	COG2909	trisaccharide binding
AANUM_RS09990	COG0058	SHG alpha-glucan phosphorylase activity
AANUM_RS09995	COG1640	4-alpha-glucanotransferase
AANUM_RS10000	COG1286	toxin biosynthetic process
AANUM_RS10005	COG3092	negative regulation of chromosome organization
AANUM_RS10010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AANUM_RS10015	COG0857	belongs to the CobB CobQ family
AANUM_RS10015	COG0280	phosphate acetyltransferase
AANUM_RS10025	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AANUM_RS10030	COG0617	tRNA 3'-terminal CCA addition
AANUM_RS10035	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AANUM_RS10040	COG2333	competence protein COMEC
AANUM_RS10040	COG0658	competence protein
AANUM_RS10045	COG1132	(ABC) transporter
AANUM_RS10050	COG1663	tetraacyldisaccharide 4'-kinase activity
AANUM_RS10055	COG2835	tetraacyldisaccharide 4'-kinase activity
AANUM_RS10065	COG0322	excinuclease ABC activity
AANUM_RS10075	COG0395	ABC-type sugar transport system, permease component
AANUM_RS10080	COG1175	transmembrane transport
AANUM_RS10095	COG3177	Filamentation induced by cAMP protein fic
AANUM_RS10105	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AANUM_RS10110	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AANUM_RS10120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AANUM_RS10135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AANUM_RS10150	COG0195	Participates in both transcription termination and antitermination
AANUM_RS10215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AANUM_RS10215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AANUM_RS10220	COG0517	IMP dehydrogenase activity
AANUM_RS10220	COG0516	GMP reductase activity
AANUM_RS10230	COG2932	Transcriptional regulator
AANUM_RS10245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AANUM_RS10250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AANUM_RS10260	COG2062	phosphohistidine phosphatase, SixA
AANUM_RS10275	COG3100	YcgL domain-containing protein
AANUM_RS10280	COG0791	NLP P60 protein
AANUM_RS10290	COG2890	protein-(glutamine-N5) methyltransferase activity
AANUM_RS10295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AANUM_RS10300	COG3133	Outer membrane lipoprotein
AANUM_RS10305	COG3102	Protein conserved in bacteria
AANUM_RS10315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AANUM_RS10320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AANUM_RS10325	COG4178	(ABC) transporter
AANUM_RS10330	COG4774	siderophore transport
AANUM_RS10340	COG0307	riboflavin synthase, alpha
AANUM_RS10345	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AANUM_RS10350	COG3657	addiction module killer protein
AANUM_RS10355	COG1534	Rna-binding protein
AANUM_RS10360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AANUM_RS10365	COG2027	D-alanyl-D-alanine carboxypeptidase
AANUM_RS10375	COG0303	'Molybdopterin
AANUM_RS10380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AANUM_RS10390	COG3118	belongs to the thioredoxin family
AANUM_RS10395	COG0492	ferredoxin-NADP+ reductase activity
AANUM_RS10400	COG4988	ABC transporter
AANUM_RS10405	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AANUM_RS10415	COG1946	Acyl-CoA thioesterase
AANUM_RS10420	COG0515	serine threonine protein kinase
AANUM_RS10440	COG1940	carbohydrate kinase activity
AANUM_RS10445	COG0671	phosphoesterase, PA-phosphatase related
AANUM_RS10465	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AANUM_RS10470	COG0708	Exodeoxyribonuclease III
AANUM_RS10505	COG1682	transport, permease protein
AANUM_RS10530	COG2951	lytic endotransglycosylase activity
AANUM_RS10535	COG1216	Glycosyl transferase, family 2
AANUM_RS10540	COG1216	Glycosyl transferase, family 2
AANUM_RS10550	COG3306	glycosyltransferase involved in LPS biosynthesis
AANUM_RS10560	COG5039	Polysaccharide pyruvyl transferase
AANUM_RS10565	COG2161	toxin-antitoxin pair type II binding
AANUM_RS10570	COG4115	mRNA cleavage
AANUM_RS10575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AANUM_RS10580	COG1793	dna ligase
AANUM_RS10585	COG0210	DNA helicase
AANUM_RS10590	COG2610	gluconate transmembrane transporter activity
AANUM_RS10595	COG3265	gluconokinase activity
AANUM_RS10600	COG1609	Transcriptional regulator
AANUM_RS10620	COG0437	4 iron, 4 sulfur cluster binding
AANUM_RS10625	COG2864	formate dehydrogenase
AANUM_RS10630	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AANUM_RS10635	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AANUM_RS10640	COG0651	ATP synthesis coupled electron transport
AANUM_RS10645	COG0650	Formate hydrogenlyase subunit 4
AANUM_RS10650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AANUM_RS10655	COG4237	Hydrogenase 4 membrane
AANUM_RS10660	COG0651	ATP synthesis coupled electron transport
AANUM_RS10665	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AANUM_RS10665	COG3261	NADH dehydrogenase
AANUM_RS10670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AANUM_RS10675	COG3260	NADH ubiquinone oxidoreductase 20
AANUM_RS10685	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AANUM_RS10695	COG3383	formate dehydrogenase (NAD+) activity
AANUM_RS10700	COG3383	formate dehydrogenase (NAD+) activity
AANUM_RS10720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AANUM_RS10730	COG0508	dehydrogenase complex catalyzes the overall conversion of
AANUM_RS10735	COG0567	Dehydrogenase, E1 component
AANUM_RS10740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AANUM_RS10745	COG3108	Peptidase M15
AANUM_RS10750	COG2989	Protein conserved in bacteria
AANUM_RS10755	COG0793	Belongs to the peptidase S41A family
AANUM_RS10760	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AANUM_RS10765	COG2995	paraquat-inducible protein a
AANUM_RS10770	COG3008	intermembrane lipid transfer
AANUM_RS10775	COG3008	intermembrane lipid transfer
AANUM_RS10785	COG3842	ATPase activity
AANUM_RS10790	COG1176	ABC-type spermidine putrescine transport system, permease component I
AANUM_RS10795	COG1177	transmembrane transport
AANUM_RS10800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AANUM_RS10815	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AANUM_RS10820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AANUM_RS10835	COG1522	sequence-specific DNA binding
AANUM_RS10845	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AANUM_RS10850	COG1178	ABC-type Fe3 transport system permease component
AANUM_RS10855	COG4143	(ABC) transporter
AANUM_RS10860	COG0351	phosphomethylpyrimidine kinase
AANUM_RS10860	COG0351	phosphomethylpyrimidine kinase
AANUM_RS10905	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AANUM_RS10940	COG2920	part of a sulfur-relay system
AANUM_RS10950	COG1121	(ABC) transporter
AANUM_RS10955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AANUM_RS10960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AANUM_RS10980	COG3304	Inner membrane component domain
AANUM_RS10985	COG1289	transmembrane transporter activity
AANUM_RS11000	COG3958	Transketolase
AANUM_RS11005	COG3959	Transketolase, thiamine diphosphate binding domain
AANUM_RS11045	COG3501	Rhs element vgr protein
AANUM_RS11050	COG4953	penicillin-binding protein 1C
AANUM_RS11055	COG2855	membrane
AANUM_RS11075	COG3842	ATPase activity
AANUM_RS11080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AANUM_RS11095	COG3676	manually curated
AANUM_RS11100	COG5339	Protein conserved in bacteria
AANUM_RS11105	COG0443	Heat shock 70 kDa protein
AANUM_RS11110	COG0484	heat shock protein binding
AANUM_RS11115	COG2337	Toxic component of a toxin-antitoxin (TA) module
AANUM_RS11130	COG0626	cystathionine gamma-synthase activity
AANUM_RS11135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AANUM_RS11155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AANUM_RS11160	COG2999	glutathione oxidoreductase activity
AANUM_RS11165	COG1530	ribonuclease E activity
AANUM_RS11170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AANUM_RS11220	COG1840	ABC-type Fe3 transport system, periplasmic component
AANUM_RS11225	COG1840	ABC-type Fe3 transport system, periplasmic component
AANUM_RS11250	COG2860	membrane
AANUM_RS11265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AANUM_RS11275	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AANUM_RS11280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AANUM_RS11285	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AANUM_RS11290	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AANUM_RS11305	COG2914	Belongs to the UPF0125 (RnfH) family
AANUM_RS11310	COG2850	peptidyl-arginine hydroxylation
AANUM_RS11315	COG1570	exodeoxyribonuclease VII activity
AANUM_RS11330	COG1137	ATPase activity
AANUM_RS11335	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AANUM_RS11340	COG3117	lipopolysaccharide transmembrane transporter activity
AANUM_RS11345	COG1127	ABC transporter
AANUM_RS11350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AANUM_RS11355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AANUM_RS11360	COG2854	intermembrane phospholipid transfer
AANUM_RS11365	COG3113	response to antibiotic
AANUM_RS11370	COG5007	Belongs to the BolA IbaG family
AANUM_RS11380	COG3691	Protein conserved in bacteria
AANUM_RS11390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AANUM_RS11400	COG0861	Integral membrane protein TerC family
AANUM_RS11410	COG1217	gtp-binding protein TYPA
AANUM_RS11415	COG3266	domain, Protein
AANUM_RS11415	COG3468	outer membrane autotransporter barrel domain protein
AANUM_RS11425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AANUM_RS11440	COG1125	glycine betaine transport
AANUM_RS11440	COG0517	IMP dehydrogenase activity
AANUM_RS11445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AANUM_RS11455	COG0527	aspartate kinase activity
AANUM_RS11455	COG0460	homoserine dehydrogenase
AANUM_RS11470	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AANUM_RS11475	COG2091	lysine biosynthetic process via aminoadipic acid
AANUM_RS11485	COG0330	HflC and HflK could
AANUM_RS11495	COG4974	Belongs to the 'phage' integrase family
AANUM_RS11515	COG3061	Opacity-associated protein A
AANUM_RS11515	COG3266	domain, Protein
AANUM_RS11520	COG1509	lysine 2,3-aminomutase activity
AANUM_RS11530	COG3033	Beta-eliminating lyase
AANUM_RS11535	COG0814	amino acid
AANUM_RS11540	COG2964	Protein conserved in bacteria
AANUM_RS11545	COG5413	integral membrane protein
AANUM_RS11555	COG0204	Acyl-transferase
AANUM_RS11565	COG0697	spore germination
AANUM_RS11570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AANUM_RS11575	COG1882	Formate acetyltransferase
AANUM_RS11580	COG1882	Formate acetyltransferase
AANUM_RS11585	COG2116	formate transmembrane transporter activity
AANUM_RS11590	COG0537	adenosine 5'-monophosphoramidase activity
AANUM_RS11630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AANUM_RS11645	COG0681	Belongs to the peptidase S26 family