locus-tag	class	description
FXN57_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXN57_RS00010	COG0592	DNA-directed DNA polymerase activity
FXN57_RS00020	COG2226	methyltransferase
FXN57_RS00035	COG0281	malic enzyme
FXN57_RS00040	COG2081	HI0933 family
FXN57_RS00045	COG4235	cytochrome complex assembly
FXN57_RS00045	COG3088	subunit of a heme lyase
FXN57_RS00050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN57_RS00055	COG1138	Cytochrome C-type biogenesis protein
FXN57_RS00065	COG3301	Polysulphide reductase, NrfD
FXN57_RS00100	COG1138	Cytochrome C-type biogenesis protein
FXN57_RS00110	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN57_RS00115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN57_RS00120	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN57_RS00125	COG4133	protoheme IX ABC transporter activity
FXN57_RS00170	COG2267	carboxylic ester hydrolase activity
FXN57_RS00175	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FXN57_RS00185	COG0436	Aminotransferase
FXN57_RS00200	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FXN57_RS00205	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FXN57_RS00210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FXN57_RS00220	COG1652	LysM domain
FXN57_RS00225	COG2321	neutral zinc metallopeptidase
FXN57_RS00235	COG3293	Transposase
FXN57_RS00245	COG0281	malic enzyme
FXN57_RS00245	COG0280	phosphate acetyltransferase
FXN57_RS00250	COG3293	Transposase
FXN57_RS00325	COG3293	Transposase
FXN57_RS00335	COG2801	Transposase and inactivated derivatives
FXN57_RS00340	COG3091	SprT-like family
FXN57_RS00345	COG0814	amino acid
FXN57_RS00350	COG1760	l-serine dehydratase
FXN57_RS00355	COG0252	asparaginase activity
FXN57_RS00365	COG3063	Type IV pilus biogenesis stability protein PilW
FXN57_RS00370	COG1426	Protein conserved in bacteria
FXN57_RS00385	COG2976	Protein conserved in bacteria
FXN57_RS00395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXN57_RS00400	COG2233	PERMEase
FXN57_RS00405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FXN57_RS00410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXN57_RS00415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FXN57_RS00425	COG0659	secondary active sulfate transmembrane transporter activity
FXN57_RS00445	COG2186	Transcriptional regulator
FXN57_RS00460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FXN57_RS00485	COG0800	Aldolase
FXN57_RS00490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FXN57_RS00500	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FXN57_RS00505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FXN57_RS00515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FXN57_RS00520	COG1555	photosystem II stabilization
FXN57_RS00530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FXN57_RS00550	COG0196	riboflavin kinase activity
FXN57_RS00555	COG0728	peptidoglycan biosynthetic process
FXN57_RS00570	COG0560	Phosphoserine phosphatase
FXN57_RS00580	COG0193	aminoacyl-tRNA hydrolase activity
FXN57_RS00585	COG0012	GTP binding
FXN57_RS00595	COG1573	uracil-dna glycosylase
FXN57_RS00600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FXN57_RS00610	COG3115	cell septum assembly
FXN57_RS00630	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FXN57_RS00635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FXN57_RS00670	COG2801	Transposase and inactivated derivatives
FXN57_RS00715	COG3161	chorismate lyase activity
FXN57_RS00725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXN57_RS00730	COG1758	RNA polymerase activity
FXN57_RS00740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FXN57_RS00775	COG2801	Transposase and inactivated derivatives
FXN57_RS00780	COG3293	Transposase
FXN57_RS00800	COG2271	Major facilitator Superfamily
FXN57_RS00810	COG1215	transferase activity, transferring glycosyl groups
FXN57_RS00815	COG1649	PFAM Uncharacterised BCR, COG1649
FXN57_RS00815	COG0726	polysaccharide deacetylase
FXN57_RS00830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FXN57_RS00835	COG0561	phosphatase activity
FXN57_RS00850	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN57_RS00850	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN57_RS00855	COG0742	ribosomal rna small subunit methyltransferase
FXN57_RS00860	COG0552	protein localization to endoplasmic reticulum
FXN57_RS00865	COG2884	Cell division ATP-binding protein ftsE
FXN57_RS00870	COG2177	Part of the ABC transporter FtsEX involved in
FXN57_RS00895	COG1720	tRNA m6t6A37 methyltransferase activity
FXN57_RS00900	COG1575	Belongs to the MenA family. Type 1 subfamily
FXN57_RS00965	COG3293	Transposase
FXN57_RS00975	COG3028	Belongs to the UPF0307 family
FXN57_RS00980	COG0312	modulator of DNA gyrase
FXN57_RS00985	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FXN57_RS00990	COG1929	Belongs to the glycerate kinase type-1 family
FXN57_RS00995	COG2610	gluconate transmembrane transporter activity
FXN57_RS01005	COG2801	Transposase and inactivated derivatives
FXN57_RS01015	COG0513	Belongs to the DEAD box helicase family
FXN57_RS01020	COG4785	May be involved in cell division
FXN57_RS01030	COG2731	YhcH YjgK YiaL family protein
FXN57_RS01035	COG3023	N-Acetylmuramoyl-L-alanine amidase
FXN57_RS01040	COG4969	Belongs to the N-Me-Phe pilin family
FXN57_RS01080	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FXN57_RS01100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FXN57_RS01140	COG0789	Transcriptional regulator
FXN57_RS01145	COG2608	mercury ion transmembrane transporter activity
FXN57_RS01150	COG2217	Heavy metal translocating P-type atpase
FXN57_RS01175	COG0740	serine-type endopeptidase activity
FXN57_RS01180	COG2194	sulfuric ester hydrolase activity
FXN57_RS01185	COG2918	glutathione biosynthetic process
FXN57_RS01185	COG1181	Belongs to the D-alanine--D-alanine ligase family
FXN57_RS01205	COG2801	Transposase and inactivated derivatives
FXN57_RS01225	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FXN57_RS01225	COG0237	dephospho-CoA kinase activity
FXN57_RS01230	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FXN57_RS01240	COG1115	amino acid carrier protein
FXN57_RS01245	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FXN57_RS01280	COG4145	pantothenate transmembrane transporter activity
FXN57_RS01285	COG3924	membrane
FXN57_RS01290	COG4783	chaperone-mediated protein folding
FXN57_RS01300	COG3293	Transposase
FXN57_RS01305	COG0439	Biotin carboxylase
FXN57_RS01310	COG0511	ligase activity, forming carbon-carbon bonds
FXN57_RS01335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FXN57_RS01345	COG0456	acetyltransferase
FXN57_RS01350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FXN57_RS01360	COG3078	GTPase activator activity
FXN57_RS01365	COG3501	Rhs element vgr protein
FXN57_RS01375	COG3201	nicotinamide mononucleotide transporter
FXN57_RS01385	COG0513	Belongs to the DEAD box helicase family
FXN57_RS01425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FXN57_RS01435	COG0251	oxidation-reduction process
FXN57_RS01440	COG2137	regulation of response to DNA damage stimulus
FXN57_RS01445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FXN57_RS01450	COG0488	(ABC) transporter
FXN57_RS01460	COG3293	Transposase
FXN57_RS01530	COG1238	metal cluster binding
FXN57_RS01535	COG0110	maltose O-acetyltransferase activity
FXN57_RS01540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FXN57_RS01565	COG0210	DNA helicase
FXN57_RS01570	COG5645	(Lipo)protein
FXN57_RS01580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FXN57_RS01580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FXN57_RS01590	COG3293	Transposase
FXN57_RS01595	COG0243	molybdopterin cofactor binding
FXN57_RS01605	COG3302	dmso reductase anchor subunit
FXN57_RS01610	COG3293	Transposase
FXN57_RS01615	COG3381	protein complex oligomerization
FXN57_RS01620	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXN57_RS01620	COG2221	Nitrite and sulphite reductase 4Fe-4S
FXN57_RS01630	COG4545	Glutaredoxin-related protein
FXN57_RS01645	COG3293	Transposase
FXN57_RS01665	COG1114	Component of the transport system for branched-chain amino acids
FXN57_RS01675	COG3293	Transposase
FXN57_RS01695	COG0561	phosphatase activity
FXN57_RS01700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FXN57_RS01705	COG1596	polysaccharide export
FXN57_RS01705	COG1555	photosystem II stabilization
FXN57_RS01725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FXN57_RS01730	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FXN57_RS01740	COG1011	Hydrolase
FXN57_RS01820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN57_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
FXN57_RS01860	COG0737	Belongs to the 5'-nucleotidase family
FXN57_RS01870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN57_RS01880	COG0859	PFAM glycosyl transferase family 9
FXN57_RS01885	COG0754	glutathionylspermidine amidase activity
FXN57_RS01890	COG3005	denitrification pathway
FXN57_RS01895	COG3043	anaerobic respiration
FXN57_RS01900	COG0348	domain, Protein
FXN57_RS01905	COG0437	4 iron, 4 sulfur cluster binding
FXN57_RS01910	COG0243	molybdopterin cofactor binding
FXN57_RS01915	COG3062	negative regulation of establishment of protein localization
FXN57_RS01920	COG3850	Histidine kinase
FXN57_RS01925	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FXN57_RS01935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FXN57_RS01950	COG0582	viral genome integration into host DNA
FXN57_RS01960	COG1070	Carbohydrate kinase
FXN57_RS01965	COG2115	Belongs to the xylose isomerase family
FXN57_RS01970	COG4213	ABC transporter substrate-binding protein
FXN57_RS01975	COG1129	ABC transporter
FXN57_RS01985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FXN57_RS01990	COG1757	Na H antiporter
FXN57_RS01995	COG1609	Transcriptional regulator
FXN57_RS01995	COG2207	Transcriptional regulator
FXN57_RS02005	COG0297	glycogen (starch) synthase activity
FXN57_RS02015	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FXN57_RS02025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN57_RS02045	COG0662	Cupin 2, conserved barrel domain protein
FXN57_RS02045	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FXN57_RS02050	COG2814	Major facilitator Superfamily
FXN57_RS02055	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN57_RS02055	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN57_RS02060	COG3715	PTS system
FXN57_RS02065	COG3716	PTS system mannose fructose sorbose family IID component
FXN57_RS02080	COG0859	PFAM glycosyl transferase family 9
FXN57_RS02085	COG1027	Aspartate ammonia-lyase
FXN57_RS02095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FXN57_RS02100	COG0459	protein refolding
FXN57_RS02130	COG3293	Transposase
FXN57_RS02155	COG3293	Transposase
FXN57_RS02170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FXN57_RS02180	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FXN57_RS02185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN57_RS02200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FXN57_RS02210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FXN57_RS02230	COG3312	ion transport
FXN57_RS02240	COG1733	regulation of RNA biosynthetic process
FXN57_RS02255	COG0716	FMN binding
FXN57_RS02265	COG1494	fructose-1,6-bisphosphatase
FXN57_RS02275	COG1045	serine acetyltransferase
FXN57_RS02285	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FXN57_RS02290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXN57_RS02295	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FXN57_RS02300	COG4988	ABC transporter
FXN57_RS02305	COG1132	(ABC) transporter
FXN57_RS02310	COG1309	transcriptional regulator
FXN57_RS02315	COG0583	DNA-binding transcription factor activity
FXN57_RS02320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FXN57_RS02320	COG0678	peroxiredoxin activity
FXN57_RS02325	COG2900	Belongs to the SlyX family
FXN57_RS02330	COG0545	Peptidyl-prolyl cis-trans isomerase
FXN57_RS02335	COG2964	Protein conserved in bacteria
FXN57_RS02340	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FXN57_RS02350	COG2168	tRNA wobble position uridine thiolation
FXN57_RS02355	COG1126	abc transporter atp-binding protein
FXN57_RS02360	COG0765	amino acid transport
FXN57_RS02365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN57_RS02370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN57_RS02400	COG1686	Belongs to the peptidase S11 family
FXN57_RS02405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN57_RS02405	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN57_RS02410	COG0772	Belongs to the SEDS family
FXN57_RS02415	COG0768	penicillin binding
FXN57_RS02425	COG0799	negative regulation of ribosome biogenesis
FXN57_RS02430	COG0513	Belongs to the DEAD box helicase family
FXN57_RS02435	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FXN57_RS02440	COG2814	Major facilitator Superfamily
FXN57_RS02450	COG1028	Short-chain dehydrogenase reductase Sdr
FXN57_RS02455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FXN57_RS02465	COG0416	fatty acid biosynthetic process
FXN57_RS02475	COG1399	metal-binding, possibly nucleic acid-binding protein
FXN57_RS02490	COG2830	Protein of unknown function (DUF452)
FXN57_RS02505	COG0688	phosphatidylethanolamine metabolic process
FXN57_RS02515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FXN57_RS02520	COG3293	Transposase
FXN57_RS02525	COG2966	Psort location CytoplasmicMembrane, score
FXN57_RS02530	COG3610	response to peptide
FXN57_RS02535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FXN57_RS02610	COG2853	Lipoprotein
FXN57_RS02615	COG0747	negative chemotaxis
FXN57_RS02650	COG0814	amino acid
FXN57_RS02660	COG4783	chaperone-mediated protein folding
FXN57_RS02665	COG3293	Transposase
FXN57_RS02675	COG0848	biopolymer transport protein
FXN57_RS02680	COG0811	peptide transport
FXN57_RS02685	COG4536	flavin adenine dinucleotide binding
FXN57_RS02690	COG4137	Cytochrome C assembly protein
FXN57_RS02695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FXN57_RS02710	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FXN57_RS02715	COG0789	Transcriptional regulator
FXN57_RS02720	COG4221	oxidoreductase activity
FXN57_RS02730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FXN57_RS02750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXN57_RS02755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FXN57_RS02760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FXN57_RS02765	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
FXN57_RS02770	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
FXN57_RS02785	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FXN57_RS02790	COG1466	dna polymerase III delta subunit
FXN57_RS02795	COG0494	nUDIX hydrolase
FXN57_RS02810	COG4701	Protein of unknown function (DUF721)
FXN57_RS02815	COG0789	Transcriptional regulator
FXN57_RS02820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FXN57_RS02840	COG3293	Transposase
FXN57_RS02855	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FXN57_RS02870	COG4796	Type ii and iii secretion system protein
FXN57_RS02890	COG4972	Pilus assembly protein
FXN57_RS02895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FXN57_RS02900	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FXN57_RS02905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXN57_RS02920	COG1309	transcriptional regulator
FXN57_RS02930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FXN57_RS02965	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN57_RS02975	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN57_RS02990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FXN57_RS03000	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN57_RS03005	COG1309	transcriptional regulator
FXN57_RS03010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN57_RS03015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXN57_RS03020	COG0500	methyltransferase
FXN57_RS03030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FXN57_RS03035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXN57_RS03040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FXN57_RS03045	COG1381	Involved in DNA repair and RecF pathway recombination
FXN57_RS03050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FXN57_RS03070	COG0354	folic acid binding
FXN57_RS03075	COG1561	YicC-like family, N-terminal region
FXN57_RS03085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FXN57_RS03100	COG3842	ATPase activity
FXN57_RS03105	COG1178	ABC-type Fe3 transport system permease component
FXN57_RS03110	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN57_RS03125	COG1194	a g-specific adenine glycosylase
FXN57_RS03150	COG3056	Lipoprotein
FXN57_RS03155	COG0271	Belongs to the BolA IbaG family
FXN57_RS03170	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN57_RS03175	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN57_RS03180	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN57_RS03185	COG2871	sodium ion transport
FXN57_RS03190	COG1477	protein flavinylation
FXN57_RS03195	COG2991	Protein conserved in bacteria
FXN57_RS03210	COG0148	phosphopyruvate hydratase activity
FXN57_RS03225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FXN57_RS03230	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
FXN57_RS03235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FXN57_RS03245	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FXN57_RS03260	COG3956	TIGRFAM MazG family protein
FXN57_RS03265	COG0402	S-adenosylhomocysteine deaminase activity
FXN57_RS03270	COG3083	sulfuric ester hydrolase activity
FXN57_RS03275	COG3082	Protein of unknown function (DUF1414)
FXN57_RS03285	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FXN57_RS03290	COG0745	RESPONSE REGULATOR receiver
FXN57_RS03295	COG2205	protein histidine kinase activity
FXN57_RS03300	COG0786	glutamate:sodium symporter activity
FXN57_RS03315	COG3012	SEC-C Motif Domain Protein
FXN57_RS03320	COG2258	MOSC domain
FXN57_RS03335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FXN57_RS03340	COG1349	DNA-binding transcription factor activity
FXN57_RS03350	COG3068	Protein conserved in bacteria
FXN57_RS03355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FXN57_RS03375	COG0248	Ppx GppA phosphatase
FXN57_RS03380	COG2911	Protein conserved in bacteria
FXN57_RS03385	COG0729	surface antigen
FXN57_RS03390	COG2197	response regulator
FXN57_RS03400	COG0181	hydroxymethylbilane synthase activity
FXN57_RS03410	COG2959	enzyme of heme biosynthesis
FXN57_RS03415	COG3071	HemY protein
FXN57_RS03420	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FXN57_RS03430	COG1595	DNA-templated transcription, initiation
FXN57_RS03440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXN57_RS03445	COG2183	response to ionizing radiation
FXN57_RS03455	COG0471	metal ion transport
FXN57_RS03460	COG0583	DNA-binding transcription factor activity
FXN57_RS03465	COG2183	response to ionizing radiation
FXN57_RS03470	COG3293	Transposase
FXN57_RS03480	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXN57_RS03485	COG1129	ABC transporter
FXN57_RS03490	COG1879	ABC-type sugar transport system periplasmic component
FXN57_RS03495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FXN57_RS03510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FXN57_RS03520	COG0583	DNA-binding transcription factor activity
FXN57_RS03525	COG2962	Rard protein
FXN57_RS03540	COG0551	DNA topoisomerase type I activity
FXN57_RS03565	COG0705	Rhomboid family
FXN57_RS03570	COG1349	DNA-binding transcription factor activity
FXN57_RS03585	COG4178	(ABC) transporter
FXN57_RS03600	COG0233	cytoplasmic translational termination
FXN57_RS03615	COG0575	Belongs to the CDS family
FXN57_RS03630	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FXN57_RS03650	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXN57_RS03660	COG0490	domain, Protein
FXN57_RS03660	COG0471	metal ion transport
FXN57_RS03675	COG4589	Belongs to the CDS family
FXN57_RS03680	COG0521	Mo-molybdopterin cofactor biosynthetic process
FXN57_RS03700	COG3276	selenocysteine insertion sequence binding
FXN57_RS03705	COG1921	L-seryl-tRNASec selenium transferase activity
FXN57_RS03710	COG0442	prolyl-tRNA aminoacylation
FXN57_RS03725	COG1595	DNA-templated transcription, initiation
FXN57_RS03730	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FXN57_RS03735	COG3026	antisigma factor binding
FXN57_RS03740	COG3086	response to oxidative stress
FXN57_RS03745	COG1763	Mo-molybdopterin cofactor biosynthetic process
FXN57_RS03750	COG0300	oxidoreductase activity
FXN57_RS03755	COG2195	Cleaves the N-terminal amino acid of tripeptides
FXN57_RS03765	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FXN57_RS03770	COG2818	Glycosylase
FXN57_RS03775	COG3477	response to acidic pH
FXN57_RS03780	COG0019	diaminopimelate decarboxylase activity
FXN57_RS03795	COG0514	ATP-dependent DNA helicase (RecQ)
FXN57_RS03800	COG0187	DNA topoisomerase II activity
FXN57_RS03805	COG1072	(Pantothenic acid kinase))
FXN57_RS03830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FXN57_RS03845	COG0561	phosphatase activity
FXN57_RS03850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FXN57_RS03855	COG2267	carboxylic ester hydrolase activity
FXN57_RS03860	COG3307	-O-antigen
FXN57_RS03865	COG0191	fructose-bisphosphate aldolase activity
FXN57_RS03875	COG3719	Belongs to the RNase T2 family
FXN57_RS03880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXN57_RS03885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FXN57_RS03890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXN57_RS03905	COG0463	Glycosyl transferase, family 2
FXN57_RS03910	COG1519	Transferase
FXN57_RS03925	COG0859	PFAM glycosyl transferase family 9
FXN57_RS03930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXN57_RS03935	COG4977	sequence-specific DNA binding
FXN57_RS03935	COG1917	Cupin 2, conserved barrel domain protein
FXN57_RS03940	COG1132	(ABC) transporter
FXN57_RS03975	COG0758	DNA mediated transformation
FXN57_RS03980	COG0584	glycerophosphoryl diester phosphodiesterase
FXN57_RS03985	COG2271	Major facilitator Superfamily
FXN57_RS03995	COG0557	exoribonuclease II activity
FXN57_RS04000	COG1077	Cell shape determining protein MreB Mrl
FXN57_RS04005	COG1792	Involved in formation and maintenance of cell shape
FXN57_RS04010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FXN57_RS04040	COG0006	proline dipeptidase activity
FXN57_RS04060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FXN57_RS04075	COG1496	oxidoreductase activity
FXN57_RS04085	COG0778	Nitroreductase
FXN57_RS04095	COG0762	integral membrane protein
FXN57_RS04115	COG0363	glucosamine-6-phosphate deaminase activity
FXN57_RS04120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FXN57_RS04125	COG1218	3'(2'),5'-bisphosphate nucleotidase
FXN57_RS04135	COG1297	OPT oligopeptide transporter protein
FXN57_RS04140	COG3293	Transposase
FXN57_RS04145	COG3059	membrane
FXN57_RS04150	COG4977	sequence-specific DNA binding
FXN57_RS04150	COG1917	Cupin 2, conserved barrel domain protein
FXN57_RS04155	COG0494	nUDIX hydrolase
FXN57_RS04160	COG1011	Hydrolase
FXN57_RS04165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FXN57_RS04170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FXN57_RS04175	COG3293	Transposase
FXN57_RS04195	COG3293	Transposase
FXN57_RS04210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXN57_RS04215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXN57_RS04220	COG0805	protein transport
FXN57_RS04245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FXN57_RS04255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FXN57_RS04265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FXN57_RS04285	COG0201	protein transport
FXN57_RS04305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FXN57_RS04320	COG0814	amino acid
FXN57_RS04335	COG3423	Transcriptional regulator
FXN57_RS04350	COG2129	metallophosphoesterase
FXN57_RS04355	COG3172	ATPase kinase involved in NAD metabolism
FXN57_RS04370	COG1739	Uncharacterized protein family UPF0029
FXN57_RS04380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FXN57_RS04385	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
FXN57_RS04425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FXN57_RS04425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FXN57_RS04430	COG0569	domain protein
FXN57_RS04440	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FXN57_RS04455	COG2841	Protein conserved in bacteria
FXN57_RS04460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FXN57_RS04465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FXN57_RS04470	COG3036	rescue of stalled ribosome
FXN57_RS04480	COG1393	Belongs to the ArsC family
FXN57_RS04490	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FXN57_RS04495	COG1522	sequence-specific DNA binding
FXN57_RS04505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FXN57_RS04510	COG0038	chloride channel
FXN57_RS04515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FXN57_RS04520	COG0549	Belongs to the carbamate kinase family
FXN57_RS04525	COG1288	antiporter activity
FXN57_RS04535	COG0183	Belongs to the thiolase family
FXN57_RS04540	COG2031	fatty acid transporter
FXN57_RS04545	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FXN57_RS04550	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FXN57_RS04560	COG0051	transcription antitermination factor activity, RNA binding
FXN57_RS04565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FXN57_RS04570	COG0088	Forms part of the polypeptide exit tunnel
FXN57_RS04575	COG0089	rRNA binding
FXN57_RS04580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FXN57_RS04585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FXN57_RS04590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FXN57_RS04595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FXN57_RS04600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FXN57_RS04605	COG0255	Belongs to the universal ribosomal protein uL29 family
FXN57_RS04610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FXN57_RS04620	COG2801	Transposase and inactivated derivatives
FXN57_RS04680	COG4964	Belongs to the GSP D family
FXN57_RS04710	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FXN57_RS04720	COG1444	tRNA N-acetyltransferase activity
FXN57_RS04725	COG3293	Transposase
FXN57_RS04730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FXN57_RS04740	COG1126	abc transporter atp-binding protein
FXN57_RS04745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN57_RS04750	COG4215	(ABC) transporter
FXN57_RS04755	COG4160	amino acid transport
FXN57_RS04760	COG1966	Carbon starvation protein
FXN57_RS04775	COG3116	cell division
FXN57_RS04780	COG0768	penicillin binding
FXN57_RS04790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FXN57_RS04800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FXN57_RS04810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FXN57_RS04825	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FXN57_RS04830	COG0849	cell division
FXN57_RS04835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FXN57_RS04845	COG0077	Prephenate dehydratase
FXN57_RS04845	COG1605	Chorismate mutase
FXN57_RS04850	COG0326	Molecular chaperone. Has ATPase activity
FXN57_RS04855	COG1393	Belongs to the ArsC family
FXN57_RS04865	COG1876	peptidase activity
FXN57_RS04870	COG0494	nUDIX hydrolase
FXN57_RS04875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FXN57_RS04920	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FXN57_RS04930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FXN57_RS04935	COG1053	succinate dehydrogenase
FXN57_RS04950	COG1120	ATPase activity
FXN57_RS04955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN57_RS04965	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FXN57_RS04980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FXN57_RS04985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FXN57_RS05015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXN57_RS05025	COG0741	lytic transglycosylase activity
FXN57_RS05030	COG2350	Protein conserved in bacteria
FXN57_RS05035	COG1607	acyl-coa hydrolase
FXN57_RS05050	COG3293	Transposase
FXN57_RS05060	COG0497	DNA recombination
FXN57_RS05070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FXN57_RS05085	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FXN57_RS05085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN57_RS05090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN57_RS05095	COG0784	Response regulator, receiver
FXN57_RS05095	COG2198	Histidine kinase
FXN57_RS05095	COG5002	protein histidine kinase activity
FXN57_RS05100	COG3293	Transposase
FXN57_RS05110	COG1129	ABC transporter
FXN57_RS05115	COG1879	ABC-type sugar transport system periplasmic component
FXN57_RS05120	COG1609	Transcriptional regulator
FXN57_RS05125	COG1085	galactose-1-phosphate uridylyltransferase
FXN57_RS05130	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FXN57_RS05135	COG2017	converts alpha-aldose to the beta-anomer
FXN57_RS05150	COG0471	metal ion transport
FXN57_RS05155	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
FXN57_RS05155	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FXN57_RS05160	COG3051	citrate lyase alpha subunit
FXN57_RS05165	COG2301	Belongs to the HpcH HpaI aldolase family
FXN57_RS05175	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
FXN57_RS05180	COG4535	Mg2 and Co2 transporter CorC
FXN57_RS05200	COG0105	UTP biosynthetic process
FXN57_RS05220	COG4942	peptidase
FXN57_RS05220	COG1388	LysM domain
FXN57_RS05230	COG1238	metal cluster binding
FXN57_RS05260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FXN57_RS05275	COG3293	Transposase
FXN57_RS05290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FXN57_RS05300	COG0733	neurotransmitter:sodium symporter activity
FXN57_RS05310	COG1285	pathogenesis
FXN57_RS05315	COG2801	Transposase and inactivated derivatives
FXN57_RS05360	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FXN57_RS05360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXN57_RS05360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXN57_RS05365	COG1105	Belongs to the carbohydrate kinase PfkB family
FXN57_RS05370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN57_RS05370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN57_RS05380	COG0746	molybdenum cofactor guanylyltransferase activity
FXN57_RS05385	COG3084	Protein conserved in bacteria
FXN57_RS05390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN57_RS05395	COG3085	chromosome segregation
FXN57_RS05450	COG0561	phosphatase activity
FXN57_RS05460	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FXN57_RS05470	COG2610	gluconate transmembrane transporter activity
FXN57_RS05475	COG3622	Belongs to the hyi family
FXN57_RS05480	COG0235	Class ii aldolase
FXN57_RS05485	COG3395	kinase activity
FXN57_RS05490	COG2084	Dehydrogenase
FXN57_RS05495	COG1349	DNA-binding transcription factor activity
FXN57_RS05500	COG0347	Belongs to the P(II) protein family
FXN57_RS05505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FXN57_RS05510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FXN57_RS05515	COG0470	DNA polymerase III
FXN57_RS05520	COG0084	hydrolase, TatD family'
FXN57_RS05530	COG1253	flavin adenine dinucleotide binding
FXN57_RS05535	COG3293	Transposase
FXN57_RS05560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FXN57_RS05565	COG4942	peptidase
FXN57_RS05570	COG2861	carbohydrate metabolic process
FXN57_RS05575	COG0606	chelatase, subunit chli
FXN57_RS05665	COG3209	COG3209 Rhs family protein
FXN57_RS05680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FXN57_RS05710	COG2990	Protein conserved in bacteria
FXN57_RS05715	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FXN57_RS05735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FXN57_RS05810	COG0195	Participates in both transcription termination and antitermination
FXN57_RS05830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FXN57_RS05855	COG3293	Transposase
FXN57_RS05860	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FXN57_RS05865	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FXN57_RS05880	COG3842	ATPase activity
FXN57_RS05890	COG0395	ABC-type sugar transport system, permease component
FXN57_RS05900	COG0322	excinuclease ABC activity
FXN57_RS05910	COG2835	tetraacyldisaccharide 4'-kinase activity
FXN57_RS05915	COG1663	tetraacyldisaccharide 4'-kinase activity
FXN57_RS05930	COG3293	Transposase
FXN57_RS05935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FXN57_RS05945	COG0617	tRNA 3'-terminal CCA addition
FXN57_RS05950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FXN57_RS05960	COG0857	belongs to the CobB CobQ family
FXN57_RS05960	COG0280	phosphate acetyltransferase
FXN57_RS05965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FXN57_RS05970	COG3092	negative regulation of chromosome organization
FXN57_RS05975	COG1286	toxin biosynthetic process
FXN57_RS05980	COG1640	4-alpha-glucanotransferase
FXN57_RS05985	COG0058	SHG alpha-glucan phosphorylase activity
FXN57_RS05990	COG2909	trisaccharide binding
FXN57_RS06000	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FXN57_RS06005	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXN57_RS06010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXN57_RS06015	COG0778	Nitroreductase
FXN57_RS06020	COG0616	signal peptide processing
FXN57_RS06025	COG0287	Prephenate dehydrogenase
FXN57_RS06025	COG1605	Chorismate mutase
FXN57_RS06030	COG0009	L-threonylcarbamoyladenylate synthase
FXN57_RS06040	COG0583	DNA-binding transcription factor activity
FXN57_RS06060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXN57_RS06065	COG2949	membrane
FXN57_RS06085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FXN57_RS06100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN57_RS06105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FXN57_RS06110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN57_RS06115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FXN57_RS06120	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
FXN57_RS06125	COG0310	cobalt ion transport
FXN57_RS06130	COG0310	cobalt ion transport
FXN57_RS06135	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FXN57_RS06140	COG1122	ATPase activity
FXN57_RS06145	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FXN57_RS06155	COG0309	Hydrogenase expression formation protein (HypE)
FXN57_RS06165	COG3293	Transposase
FXN57_RS06190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXN57_RS06195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FXN57_RS06200	COG0795	lipopolysaccharide-transporting ATPase activity
FXN57_RS06205	COG0795	lipopolysaccharide-transporting ATPase activity
FXN57_RS06220	COG4149	molybdate abc transporter
FXN57_RS06225	COG0725	ABC transporter, periplasmic molybdate-binding protein
FXN57_RS06230	COG2005	Transcriptional regulator
FXN57_RS06235	COG0471	metal ion transport
FXN57_RS06245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXN57_RS06250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXN57_RS06250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXN57_RS06255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXN57_RS06265	COG0583	DNA-binding transcription factor activity
FXN57_RS06270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FXN57_RS06285	COG0039	L-malate dehydrogenase activity
FXN57_RS06290	COG1438	arginine binding
FXN57_RS06295	COG1090	epimerase
FXN57_RS06300	COG4657	Part of a membrane complex involved in electron transport
FXN57_RS06330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FXN57_RS06335	COG0733	neurotransmitter:sodium symporter activity
FXN57_RS06340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN57_RS06350	COG0739	heme binding
FXN57_RS06355	COG4604	ABC transporter, ATP-binding protein
FXN57_RS06360	COG4605	iron ion homeostasis
FXN57_RS06365	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN57_RS06370	COG4607	ABC-type enterochelin transport system periplasmic component
FXN57_RS06375	COG0737	Belongs to the 5'-nucleotidase family
FXN57_RS06390	COG3111	PFAM Bacterial OB fold (BOF) protein
FXN57_RS06395	COG0745	RESPONSE REGULATOR receiver
FXN57_RS06400	COG0642	Histidine kinase
FXN57_RS06405	COG0405	Gamma-glutamyltransferase
FXN57_RS06410	COG3293	Transposase
FXN57_RS06425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN57_RS06430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FXN57_RS06475	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FXN57_RS06485	COG0583	DNA-binding transcription factor activity
FXN57_RS06490	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FXN57_RS06495	COG1687	branched-chain amino acid
FXN57_RS06500	COG0612	Peptidase, M16
FXN57_RS06510	COG2990	Protein conserved in bacteria
FXN57_RS06520	COG0539	negative regulation of cytoplasmic translation
FXN57_RS06525	COG0776	regulation of translation
FXN57_RS06530	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FXN57_RS06535	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FXN57_RS06545	COG0023	Translation Initiation Factor
FXN57_RS06550	COG3094	Invasion gene expression up-regulator, SirB
FXN57_RS06555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FXN57_RS06560	COG0735	belongs to the Fur family
FXN57_RS06565	COG0716	FMN binding
FXN57_RS06575	COG0596	Alpha beta hydrolase
FXN57_RS06580	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FXN57_RS06585	COG0318	PFAM AMP-dependent synthetase and ligase
FXN57_RS06590	COG3264	Mechanosensitive ion channel
FXN57_RS06590	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FXN57_RS06595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FXN57_RS06600	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FXN57_RS06605	COG0730	response to heat
FXN57_RS06610	COG1560	Kdo2-lipid A biosynthetic process
FXN57_RS06620	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FXN57_RS06630	COG0463	Glycosyl transferase, family 2
FXN57_RS06640	COG0251	oxidation-reduction process
FXN57_RS06650	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FXN57_RS06655	COG1757	Na H antiporter
FXN57_RS06660	COG2916	Histone family protein nucleoid-structuring protein H-NS
FXN57_RS06665	COG0788	formyltetrahydrofolate deformylase activity
FXN57_RS06675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FXN57_RS06685	COG3842	ATPase activity
FXN57_RS06720	COG3293	Transposase
FXN57_RS06735	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FXN57_RS06740	COG3098	single-species biofilm formation
FXN57_RS06755	COG1278	Cold shock
FXN57_RS06765	COG1067	ATP-dependent peptidase activity
FXN57_RS06770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FXN57_RS06780	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FXN57_RS06785	COG1074	ATP-dependent DNA helicase activity
FXN57_RS06790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXN57_RS06810	COG0101	tRNA pseudouridine synthase activity
FXN57_RS06815	COG2026	Addiction module toxin, RelE StbE family
FXN57_RS06825	COG0471	metal ion transport
FXN57_RS06830	COG2315	Protein conserved in bacteria
FXN57_RS06835	COG0243	molybdopterin cofactor binding
FXN57_RS06840	COG3005	denitrification pathway
FXN57_RS06860	COG3293	Transposase
FXN57_RS06885	COG3293	Transposase
FXN57_RS06895	COG1448	Aminotransferase
FXN57_RS06900	COG0308	aminopeptidase N
FXN57_RS06905	COG0167	dihydroorotate dehydrogenase activity
FXN57_RS06910	COG0613	PHP domain protein
FXN57_RS06930	COG0589	response to stress
FXN57_RS06935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FXN57_RS06940	COG1528	Iron-storage protein
FXN57_RS06945	COG1528	Iron-storage protein
FXN57_RS06970	COG2925	Exonuclease
FXN57_RS06975	COG0697	spore germination
FXN57_RS06980	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FXN57_RS06985	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FXN57_RS06995	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FXN57_RS07000	COG1686	Belongs to the peptidase S11 family
FXN57_RS07010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FXN57_RS07015	COG0586	Pfam SNARE associated Golgi protein
FXN57_RS07020	COG0058	SHG alpha-glucan phosphorylase activity
FXN57_RS07035	COG3293	Transposase
FXN57_RS07040	COG0488	(ABC) transporter
FXN57_RS07045	COG3657	addiction module killer protein
FXN57_RS07060	COG1346	cytolysis
FXN57_RS07070	COG3293	Transposase
FXN57_RS07085	COG1129	ABC transporter
FXN57_RS07085	COG0842	Transport permease protein
FXN57_RS07090	COG0842	Transport permease protein
FXN57_RS07105	COG0791	NLP P60 protein
FXN57_RS07120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FXN57_RS07135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FXN57_RS07135	COG0517	IMP dehydrogenase activity
FXN57_RS07145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FXN57_RS07150	COG0512	Glutamine amidotransferase of anthranilate synthase
FXN57_RS07155	COG1942	4-Oxalocrotonate Tautomerase
FXN57_RS07165	COG0134	indole-3-glycerol-phosphate synthase activity
FXN57_RS07165	COG0135	phosphoribosylanthranilate isomerase activity
FXN57_RS07175	COG0298	carbon dioxide binding
FXN57_RS07190	COG3293	Transposase
FXN57_RS07195	COG3630	sodium ion export across plasma membrane
FXN57_RS07230	COG4221	oxidoreductase activity
FXN57_RS07235	COG0133	tryptophan synthase activity
FXN57_RS07245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN57_RS07255	COG0469	pyruvate kinase activity
FXN57_RS07265	COG3293	Transposase
FXN57_RS07275	COG1879	ABC-type sugar transport system periplasmic component
FXN57_RS07295	COG3293	Transposase
FXN57_RS07320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FXN57_RS07325	COG1940	carbohydrate kinase activity
FXN57_RS07335	COG2969	positive regulation of protein catabolic process
FXN57_RS07345	COG0314	molybdopterin synthase activity
FXN57_RS07350	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FXN57_RS07360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FXN57_RS07370	COG3293	Transposase
FXN57_RS07385	COG1120	ATPase activity
FXN57_RS07395	COG3585	molybdate ion transport
FXN57_RS07405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN57_RS07410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FXN57_RS07420	COG4774	siderophore transport
FXN57_RS07435	COG1525	nuclease
FXN57_RS07440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FXN57_RS07445	COG2166	iron-sulfur cluster assembly
FXN57_RS07450	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FXN57_RS07450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FXN57_RS07455	COG1560	Kdo2-lipid A biosynthetic process
FXN57_RS07460	COG3381	protein complex oligomerization
FXN57_RS07465	COG2249	NAD(P)H dehydrogenase (quinone) activity
FXN57_RS07475	COG0330	HflC and HflK could
FXN57_RS07500	COG1858	cytochrome C peroxidase
FXN57_RS07505	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FXN57_RS07510	COG0318	PFAM AMP-dependent synthetase and ligase
FXN57_RS07515	COG3065	identical protein binding
FXN57_RS07520	COG1214	PFAM Peptidase M22, glycoprotease
FXN57_RS07525	COG1199	ATP-dependent helicase activity
FXN57_RS07540	COG4580	involved in the transport of maltose and maltodextrins
FXN57_RS07545	COG3842	ATPase activity
FXN57_RS07550	COG2182	Extracellular solute-binding protein
FXN57_RS07560	COG3833	ABC-type maltose transport systems, permease component
FXN57_RS07565	COG0366	Alpha amylase catalytic
FXN57_RS07570	COG3842	ATPase activity
FXN57_RS07580	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN57_RS07585	COG3293	Transposase
FXN57_RS07600	COG0732	type I restriction modification DNA specificity domain
FXN57_RS07630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN57_RS07640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN57_RS07650	COG0633	Ferredoxin
FXN57_RS07665	COG1280	lysine exporter protein (LysE YggA)
FXN57_RS07670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FXN57_RS07675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FXN57_RS07685	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FXN57_RS07690	COG3293	Transposase
FXN57_RS07705	COG0166	Belongs to the GPI family
FXN57_RS07715	COG0305	Participates in initiation and elongation during chromosome replication
FXN57_RS07720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FXN57_RS07725	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXN57_RS07730	COG1136	(ABC) transporter
FXN57_RS07735	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXN57_RS07755	COG3293	Transposase
FXN57_RS07785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN57_RS07790	COG0577	efflux transmembrane transporter activity
FXN57_RS07790	COG1136	(ABC) transporter
FXN57_RS07795	COG1538	Outer membrane efflux protein
FXN57_RS07805	COG2824	Alkylphosphonate utilization operon protein PhnA
FXN57_RS07815	COG0564	pseudouridine synthase activity
FXN57_RS07820	COG2431	L-lysine efflux transmembrane transporter activity
FXN57_RS07830	COG0406	alpha-ribazole phosphatase activity
FXN57_RS07835	COG0285	dihydrofolate synthase activity
FXN57_RS07850	COG0142	geranyltranstransferase activity
FXN57_RS07860	COG1349	DNA-binding transcription factor activity
FXN57_RS07865	COG1063	alcohol dehydrogenase
FXN57_RS07870	COG3775	system Galactitol-specific IIC component
FXN57_RS07875	COG3414	Phosphotransferase system galactitol-specific IIB component
FXN57_RS07880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN57_RS07890	COG3684	Belongs to the aldolase LacD family
FXN57_RS07900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FXN57_RS07905	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FXN57_RS07955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXN57_RS07960	COG0512	Glutamine amidotransferase of anthranilate synthase
FXN57_RS07970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FXN57_RS08000	COG4166	transmembrane transport
FXN57_RS08005	COG2832	Protein of unknown function (DUF454)
FXN57_RS08010	COG0339	signal peptide processing
FXN57_RS08015	COG2190	(PTS) system
FXN57_RS08020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FXN57_RS08025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN57_RS08050	COG2194	sulfuric ester hydrolase activity
FXN57_RS08060	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FXN57_RS08070	COG2246	polysaccharide biosynthetic process
FXN57_RS08080	COG0802	atpase or kinase
FXN57_RS08085	COG1388	LysM domain
FXN57_RS08085	COG0860	N-Acetylmuramoyl-L-alanine amidase
FXN57_RS08100	COG1923	regulation of RNA biosynthetic process
FXN57_RS08105	COG3283	Transcriptional regulator of aromatic amino acids metabolism
FXN57_RS08115	COG3106	COG3106 Predicted ATPase
FXN57_RS08120	COG4166	transmembrane transport
FXN57_RS08125	COG4168	peptide transport system, permease
FXN57_RS08130	COG4171	peptide transport system, permease
FXN57_RS08135	COG4172	Belongs to the ABC transporter superfamily
FXN57_RS08140	COG4172	Belongs to the ABC transporter superfamily
FXN57_RS08180	COG0516	GMP reductase activity
FXN57_RS08180	COG0517	IMP dehydrogenase activity
FXN57_RS08190	COG2932	Transcriptional regulator
FXN57_RS08200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FXN57_RS08205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FXN57_RS08215	COG2062	phosphohistidine phosphatase, SixA
FXN57_RS08230	COG3100	YcgL domain-containing protein
FXN57_RS08240	COG0791	NLP P60 protein
FXN57_RS08250	COG2890	protein-(glutamine-N5) methyltransferase activity
FXN57_RS08255	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FXN57_RS08260	COG3133	Outer membrane lipoprotein
FXN57_RS08265	COG3102	Protein conserved in bacteria
FXN57_RS08275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FXN57_RS08280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FXN57_RS08285	COG4178	(ABC) transporter
FXN57_RS08290	COG4774	siderophore transport
FXN57_RS08300	COG0307	riboflavin synthase, alpha
FXN57_RS08305	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXN57_RS08310	COG3657	addiction module killer protein
FXN57_RS08315	COG1534	Rna-binding protein
FXN57_RS08320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXN57_RS08325	COG2027	D-alanyl-D-alanine carboxypeptidase
FXN57_RS08335	COG0303	'Molybdopterin
FXN57_RS08340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FXN57_RS08350	COG3118	belongs to the thioredoxin family
FXN57_RS08355	COG0492	ferredoxin-NADP+ reductase activity
FXN57_RS08360	COG4988	ABC transporter
FXN57_RS08365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FXN57_RS08375	COG1946	Acyl-CoA thioesterase
FXN57_RS08380	COG0515	serine threonine protein kinase
FXN57_RS08400	COG0671	phosphoesterase, PA-phosphatase related
FXN57_RS08420	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FXN57_RS08425	COG0708	Exodeoxyribonuclease III
FXN57_RS08430	COG2951	lytic endotransglycosylase activity
FXN57_RS08435	COG1216	Glycosyl transferase, family 2
FXN57_RS08440	COG1216	Glycosyl transferase, family 2
FXN57_RS08450	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN57_RS08455	COG3293	Transposase
FXN57_RS08465	COG5039	Polysaccharide pyruvyl transferase
FXN57_RS08470	COG2161	toxin-antitoxin pair type II binding
FXN57_RS08475	COG4115	mRNA cleavage
FXN57_RS08480	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FXN57_RS08485	COG1793	dna ligase
FXN57_RS08490	COG0210	DNA helicase
FXN57_RS08495	COG2610	gluconate transmembrane transporter activity
FXN57_RS08500	COG3265	gluconokinase activity
FXN57_RS08505	COG1609	Transcriptional regulator
FXN57_RS08525	COG0437	4 iron, 4 sulfur cluster binding
FXN57_RS08530	COG2864	formate dehydrogenase
FXN57_RS08535	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FXN57_RS08545	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXN57_RS08555	COG0650	Formate hydrogenlyase subunit 4
FXN57_RS08560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FXN57_RS08565	COG4237	Hydrogenase 4 membrane
FXN57_RS08570	COG0651	ATP synthesis coupled electron transport
FXN57_RS08575	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
FXN57_RS08575	COG3261	NADH dehydrogenase
FXN57_RS08585	COG3260	NADH ubiquinone oxidoreductase 20
FXN57_RS08595	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FXN57_RS08650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FXN57_RS08660	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXN57_RS08665	COG0567	Dehydrogenase, E1 component
FXN57_RS08670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN57_RS08675	COG3108	Peptidase M15
FXN57_RS08680	COG2989	Protein conserved in bacteria
FXN57_RS08685	COG0793	Belongs to the peptidase S41A family
FXN57_RS08695	COG2995	paraquat-inducible protein a
FXN57_RS08700	COG3008	intermembrane lipid transfer
FXN57_RS08765	COG3293	Transposase
FXN57_RS08805	COG1940	carbohydrate kinase activity
FXN57_RS08805	COG1846	Transcriptional regulator
FXN57_RS08815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN57_RS08820	COG2226	methyltransferase
FXN57_RS08830	COG3422	double-strand break repair
FXN57_RS08840	COG1944	ATP diphosphatase activity
FXN57_RS08845	COG3105	Protein conserved in bacteria
FXN57_RS08850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXN57_RS08870	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FXN57_RS08875	COG3683	transport system, periplasmic component
FXN57_RS08880	COG0488	(ABC) transporter
FXN57_RS08890	COG3293	Transposase
FXN57_RS08895	COG0187	DNA topoisomerase II activity
FXN57_RS08905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FXN57_RS08910	COG0625	glutathione transferase activity
FXN57_RS08915	COG2885	chlorophyll binding
FXN57_RS08915	COG3047	cAMP biosynthetic process
FXN57_RS08920	COG0616	signal peptide processing
FXN57_RS08925	COG3293	Transposase
FXN57_RS08935	COG1252	NADH dehydrogenase
FXN57_RS08945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FXN57_RS08955	COG0792	nuclease activity
FXN57_RS08960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FXN57_RS08965	COG2823	Periplasmic or secreted lipoprotein
FXN57_RS08970	COG0288	reversible hydration of carbon dioxide
FXN57_RS08975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXN57_RS08975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXN57_RS08980	COG0785	Cytochrome C biogenesis protein
FXN57_RS08985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN57_RS09005	COG3069	C4-dicarboxylate transmembrane transporter activity
FXN57_RS09015	COG3077	Addiction module antitoxin, RelB DinJ family
FXN57_RS09020	COG3041	Addiction module toxin RelE StbE family
FXN57_RS09035	COG2351	hydroxyisourate hydrolase activity
FXN57_RS09040	COG0825	malonyl-CoA metabolic process
FXN57_RS09055	COG2252	PERMEase
FXN57_RS09060	COG3152	Membrane
FXN57_RS09065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FXN57_RS09070	COG0375	protein maturation
FXN57_RS09075	COG2814	Major facilitator Superfamily
FXN57_RS09080	COG0563	adenylate kinase activity
FXN57_RS09085	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FXN57_RS09090	COG3025	triphosphatase activity
FXN57_RS09095	COG1392	Phosphate transport regulator
FXN57_RS09100	COG0306	phosphate transporter
FXN57_RS09105	COG4991	sh3 domain protein
FXN57_RS09115	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FXN57_RS09120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FXN57_RS09135	COG1620	l-lactate permease
FXN57_RS09155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FXN57_RS09165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXN57_RS09185	COG2026	Addiction module toxin, RelE StbE family
FXN57_RS09200	COG0826	peptidase U32
FXN57_RS09210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FXN57_RS09220	COG1862	Preprotein translocase
FXN57_RS09225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FXN57_RS09230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FXN57_RS09240	COG3293	Transposase
FXN57_RS09245	COG1012	belongs to the aldehyde dehydrogenase family
FXN57_RS09245	COG1454	alcohol dehydrogenase
FXN57_RS09250	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXN57_RS09255	COG1129	ABC transporter
FXN57_RS09270	COG0673	inositol 2-dehydrogenase activity
FXN57_RS09310	COG0720	synthase
FXN57_RS09315	COG0602	queuosine metabolic process
FXN57_RS09320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FXN57_RS09325	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FXN57_RS09375	COG0783	Belongs to the Dps family
FXN57_RS09380	COG3293	Transposase
FXN57_RS09385	COG1566	PFAM secretion protein HlyD family protein
FXN57_RS09440	COG2927	DNA polymerase III (CHI subunit)
FXN57_RS09445	COG0114	fumarate hydratase activity
FXN57_RS09450	COG2268	Band 7 protein
FXN57_RS09465	COG0778	Nitroreductase
FXN57_RS09470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FXN57_RS09480	COG0814	amino acid
FXN57_RS09520	COG0235	Class ii aldolase
FXN57_RS09525	COG3623	hexulose-6-phosphate isomerase
FXN57_RS09550	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FXN57_RS09575	COG3293	Transposase
FXN57_RS09590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXN57_RS09595	COG3962	Belongs to the TPP enzyme family
FXN57_RS09605	COG0673	inositol 2-dehydrogenase activity
FXN57_RS09610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN57_RS09615	COG2274	protein secretion by the type I secretion system
FXN57_RS09620	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FXN57_RS09625	COG2994	toxin metabolic process
FXN57_RS09635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FXN57_RS09655	COG2813	Specifically methylates the guanine in position
FXN57_RS09660	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
FXN57_RS09665	COG0456	acetyltransferase
FXN57_RS09670	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FXN57_RS09685	COG4795	General secretion pathway protein
FXN57_RS09710	COG3064	Membrane
FXN57_RS09715	COG0848	biopolymer transport protein
FXN57_RS09720	COG0811	peptide transport
FXN57_RS09725	COG0824	Thioesterase
FXN57_RS09740	COG1294	oxidase, subunit
FXN57_RS09745	COG1271	oxidase subunit
FXN57_RS09775	COG0217	transcriptional regulatory protein
FXN57_RS09780	COG0494	nUDIX hydrolase
FXN57_RS09790	COG3293	Transposase
FXN57_RS09800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FXN57_RS09805	COG1755	Isoprenylcysteine carboxyl methyltransferase
FXN57_RS09820	COG2271	Major facilitator Superfamily
FXN57_RS09825	COG4771	TonB-dependent receptor
FXN57_RS09830	COG0346	lactoylglutathione lyase activity
FXN57_RS09835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXN57_RS09840	COG2056	Na+-H+ antiporter family
FXN57_RS09865	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FXN57_RS09870	COG0142	geranyltranstransferase activity
FXN57_RS09890	COG0697	spore germination
FXN57_RS09895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FXN57_RS09905	COG4166	transmembrane transport
FXN57_RS09910	COG0601	transmembrane transport
FXN57_RS09915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FXN57_RS09920	COG0444	Belongs to the ABC transporter superfamily
FXN57_RS09925	COG4608	Belongs to the ABC transporter superfamily
FXN57_RS09930	COG0745	RESPONSE REGULATOR receiver
FXN57_RS09935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FXN57_RS09945	COG1611	Belongs to the LOG family
FXN57_RS09955	COG3293	Transposase
FXN57_RS09960	COG2259	Doxx family
FXN57_RS09970	COG1530	ribonuclease E activity
FXN57_RS09990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXN57_RS09995	COG0626	cystathionine gamma-synthase activity
FXN57_RS10035	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FXN57_RS10040	COG1959	2 iron, 2 sulfur cluster binding
FXN57_RS10050	COG0822	iron-sulfur transferase activity
FXN57_RS10055	COG3293	Transposase
FXN57_RS10070	COG0443	Heat shock 70 kDa protein
FXN57_RS10075	COG0633	Ferredoxin
FXN57_RS10080	COG2975	iron-sulfur cluster assembly
FXN57_RS10085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXN57_RS10085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXN57_RS10090	COG0489	protein tyrosine kinase activity
FXN57_RS10120	COG0590	tRNA wobble adenosine to inosine editing
FXN57_RS10135	COG0730	response to heat
FXN57_RS10145	COG1869	D-ribose catabolic process
FXN57_RS10160	COG3617	BRO family, N-terminal domain
FXN57_RS10175	COG1598	PFAM Uncharacterised protein family UPF0150
FXN57_RS10210	COG0582	viral genome integration into host DNA
FXN57_RS10245	COG0165	Argininosuccinate lyase
FXN57_RS10250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FXN57_RS10255	COG0753	catalase activity
FXN57_RS10270	COG0587	DNA-directed DNA polymerase activity
FXN57_RS10275	COG1022	Amp-dependent synthetase and ligase
FXN57_RS10290	COG1328	CTP reductase activity
FXN57_RS10290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXN57_RS10295	COG0602	queuosine metabolic process
FXN57_RS10300	COG0084	hydrolase, TatD family'
FXN57_RS10305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FXN57_RS10360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FXN57_RS10365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FXN57_RS10375	COG0024	Methionine aminopeptidase
FXN57_RS10380	COG0316	Belongs to the HesB IscA family
FXN57_RS10390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXN57_RS10395	COG0672	)-iron permease
FXN57_RS10410	COG1136	(ABC) transporter
FXN57_RS10410	COG0577	efflux transmembrane transporter activity
FXN57_RS10420	COG0577	efflux transmembrane transporter activity
FXN57_RS10420	COG1136	(ABC) transporter
FXN57_RS10425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN57_RS10435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FXN57_RS10455	COG1643	Atp-dependent helicase
FXN57_RS10460	COG2363	Small membrane protein
FXN57_RS10480	COG3293	Transposase
FXN57_RS10485	COG0277	FAD linked oxidase domain protein
FXN57_RS10485	COG0247	lactate metabolic process
FXN57_RS10500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FXN57_RS10505	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FXN57_RS10510	COG0363	glucosamine-6-phosphate deaminase activity
FXN57_RS10515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXN57_RS10520	COG1737	Transcriptional regulator
FXN57_RS10530	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FXN57_RS10535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FXN57_RS10550	COG2190	(PTS) system
FXN57_RS10550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN57_RS10550	COG1263	PTS System
FXN57_RS10590	COG3842	ATPase activity
FXN57_RS10595	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN57_RS10600	COG1177	transmembrane transport
FXN57_RS10605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN57_RS10620	COG3293	Transposase
FXN57_RS10630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FXN57_RS10645	COG1522	sequence-specific DNA binding
FXN57_RS10655	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FXN57_RS10660	COG1178	ABC-type Fe3 transport system permease component
FXN57_RS10665	COG4143	(ABC) transporter
FXN57_RS10710	COG2920	part of a sulfur-relay system
FXN57_RS10720	COG1121	(ABC) transporter
FXN57_RS10725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN57_RS10730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN57_RS10750	COG3304	Inner membrane component domain
FXN57_RS10755	COG1289	transmembrane transporter activity
FXN57_RS10770	COG3958	Transketolase
FXN57_RS10775	COG3959	Transketolase, thiamine diphosphate binding domain
FXN57_RS10815	COG3293	Transposase
FXN57_RS10835	COG3501	Rhs element vgr protein
FXN57_RS10855	COG4953	penicillin-binding protein 1C
FXN57_RS10860	COG3293	Transposase
FXN57_RS10865	COG2855	membrane
FXN57_RS10880	COG0157	Belongs to the NadC ModD family
FXN57_RS10885	COG3842	ATPase activity
FXN57_RS10890	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FXN57_RS10895	COG0725	ABC transporter, periplasmic molybdate-binding protein
FXN57_RS10905	COG5339	Protein conserved in bacteria
FXN57_RS10910	COG0443	Heat shock 70 kDa protein
FXN57_RS10915	COG0484	heat shock protein binding
FXN57_RS10920	COG2337	Toxic component of a toxin-antitoxin (TA) module
FXN57_RS10935	COG0626	cystathionine gamma-synthase activity
FXN57_RS10940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FXN57_RS11030	COG2337	Toxic component of a toxin-antitoxin (TA) module
FXN57_RS11080	COG3021	interspecies interaction between organisms
FXN57_RS11110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FXN57_RS11125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FXN57_RS11130	COG2999	glutathione oxidoreductase activity
FXN57_RS11135	COG1530	ribonuclease E activity
FXN57_RS11140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXN57_RS11165	COG3293	Transposase
FXN57_RS11175	COG3293	Transposase
FXN57_RS11200	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN57_RS11205	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN57_RS11230	COG3293	Transposase
FXN57_RS11240	COG2860	membrane
FXN57_RS11255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FXN57_RS11265	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FXN57_RS11270	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FXN57_RS11275	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FXN57_RS11280	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FXN57_RS11305	COG2850	peptidyl-arginine hydroxylation
FXN57_RS11320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN57_RS11325	COG1137	ATPase activity
FXN57_RS11330	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FXN57_RS11335	COG3117	lipopolysaccharide transmembrane transporter activity
FXN57_RS11340	COG1127	ABC transporter
FXN57_RS11345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FXN57_RS11350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FXN57_RS11355	COG2854	intermembrane phospholipid transfer
FXN57_RS11360	COG3113	response to antibiotic
FXN57_RS11365	COG5007	Belongs to the BolA IbaG family
FXN57_RS11385	COG3293	Transposase
FXN57_RS11390	COG3691	Protein conserved in bacteria
FXN57_RS11400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FXN57_RS11410	COG0861	Integral membrane protein TerC family
FXN57_RS11420	COG1217	gtp-binding protein TYPA
FXN57_RS11435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FXN57_RS11440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXN57_RS11460	COG0517	IMP dehydrogenase activity
FXN57_RS11460	COG1125	glycine betaine transport
FXN57_RS11465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FXN57_RS11475	COG0460	homoserine dehydrogenase
FXN57_RS11475	COG0527	aspartate kinase activity
FXN57_RS11490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FXN57_RS11495	COG2091	lysine biosynthetic process via aminoadipic acid
FXN57_RS11500	COG0330	HflC and HflK could
FXN57_RS11505	COG0330	HflC and HflK could
FXN57_RS11520	COG4974	Belongs to the 'phage' integrase family
FXN57_RS11525	COG2814	Major facilitator Superfamily
FXN57_RS11530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FXN57_RS11545	COG3266	domain, Protein
FXN57_RS11545	COG3061	Opacity-associated protein A
FXN57_RS11550	COG1509	lysine 2,3-aminomutase activity
FXN57_RS11560	COG3293	Transposase
FXN57_RS11570	COG3033	Beta-eliminating lyase
FXN57_RS11575	COG0814	amino acid
FXN57_RS11580	COG2964	Protein conserved in bacteria
FXN57_RS11585	COG5413	integral membrane protein
FXN57_RS11595	COG0204	Acyl-transferase
FXN57_RS11605	COG0697	spore germination
FXN57_RS11610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FXN57_RS11615	COG1882	Formate acetyltransferase
FXN57_RS11620	COG2116	formate transmembrane transporter activity
FXN57_RS11625	COG3293	Transposase
FXN57_RS11630	COG0537	adenosine 5'-monophosphoramidase activity
FXN57_RS11665	COG3022	response to hydroperoxide
FXN57_RS11670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FXN57_RS11685	COG0681	Belongs to the peptidase S26 family