locus-tag	class	description
ACT74_RS00010	COG2801	Transposase and inactivated derivatives
ACT74_RS00020	COG0859	PFAM glycosyl transferase family 9
ACT74_RS00025	COG1027	Aspartate ammonia-lyase
ACT74_RS00035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACT74_RS00040	COG0459	protein refolding
ACT74_RS00060	COG2801	Transposase and inactivated derivatives
ACT74_RS00070	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACT74_RS00075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACT74_RS00080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACT74_RS00085	COG1381	Involved in DNA repair and RecF pathway recombination
ACT74_RS00090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACT74_RS00105	COG0354	folic acid binding
ACT74_RS00110	COG1561	YicC-like family, N-terminal region
ACT74_RS00120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACT74_RS00130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACT74_RS00140	COG3842	ATPase activity
ACT74_RS00145	COG1178	ABC-type Fe3 transport system permease component
ACT74_RS00150	COG1840	ABC-type Fe3 transport system, periplasmic component
ACT74_RS00155	COG3171	Protein conserved in bacteria
ACT74_RS00165	COG1194	a g-specific adenine glycosylase
ACT74_RS00190	COG3056	Lipoprotein
ACT74_RS00195	COG0271	Belongs to the BolA IbaG family
ACT74_RS00210	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ACT74_RS00215	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ACT74_RS00220	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ACT74_RS00225	COG2871	sodium ion transport
ACT74_RS00230	COG1477	protein flavinylation
ACT74_RS00235	COG2991	Protein conserved in bacteria
ACT74_RS00245	COG0148	phosphopyruvate hydratase activity
ACT74_RS00260	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACT74_RS00265	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ACT74_RS00270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACT74_RS00275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACT74_RS00280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACT74_RS00295	COG3956	TIGRFAM MazG family protein
ACT74_RS00300	COG0402	S-adenosylhomocysteine deaminase activity
ACT74_RS00305	COG3083	sulfuric ester hydrolase activity
ACT74_RS00310	COG3082	Protein of unknown function (DUF1414)
ACT74_RS00320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACT74_RS00325	COG0745	RESPONSE REGULATOR receiver
ACT74_RS00330	COG2205	protein histidine kinase activity
ACT74_RS00335	COG0786	glutamate:sodium symporter activity
ACT74_RS00350	COG3012	SEC-C Motif Domain Protein
ACT74_RS00355	COG2258	MOSC domain
ACT74_RS00360	COG0433	COG0433 Predicted ATPase
ACT74_RS00375	COG0656	L-ascorbic acid biosynthetic process
ACT74_RS00380	COG0667	Aldo Keto reductase
ACT74_RS00385	COG2272	Belongs to the type-B carboxylesterase lipase family
ACT74_RS00410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACT74_RS00415	COG1349	DNA-binding transcription factor activity
ACT74_RS00425	COG3068	Protein conserved in bacteria
ACT74_RS00430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACT74_RS00450	COG0248	Ppx GppA phosphatase
ACT74_RS00455	COG2911	Protein conserved in bacteria
ACT74_RS00460	COG0729	surface antigen
ACT74_RS00465	COG2197	response regulator
ACT74_RS00475	COG0181	hydroxymethylbilane synthase activity
ACT74_RS00485	COG2959	enzyme of heme biosynthesis
ACT74_RS00490	COG3071	HemY protein
ACT74_RS00495	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ACT74_RS00505	COG1595	DNA-templated transcription, initiation
ACT74_RS00515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACT74_RS00525	COG0471	metal ion transport
ACT74_RS00530	COG0583	DNA-binding transcription factor activity
ACT74_RS00535	COG2183	response to ionizing radiation
ACT74_RS00545	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACT74_RS00550	COG1129	ABC transporter
ACT74_RS00555	COG1879	ABC-type sugar transport system periplasmic component
ACT74_RS00560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACT74_RS00585	COG1072	(Pantothenic acid kinase))
ACT74_RS00590	COG0187	DNA topoisomerase II activity
ACT74_RS00595	COG0514	ATP-dependent DNA helicase (RecQ)
ACT74_RS00605	COG0019	diaminopimelate decarboxylase activity
ACT74_RS00610	COG3477	response to acidic pH
ACT74_RS00615	COG2818	Glycosylase
ACT74_RS00620	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACT74_RS00630	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACT74_RS00635	COG0300	oxidoreductase activity
ACT74_RS00640	COG1763	Mo-molybdopterin cofactor biosynthetic process
ACT74_RS00645	COG3086	response to oxidative stress
ACT74_RS00650	COG3026	antisigma factor binding
ACT74_RS00655	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ACT74_RS00660	COG1595	DNA-templated transcription, initiation
ACT74_RS00675	COG0442	prolyl-tRNA aminoacylation
ACT74_RS00680	COG1921	L-seryl-tRNASec selenium transferase activity
ACT74_RS00685	COG3276	selenocysteine insertion sequence binding
ACT74_RS00705	COG0733	neurotransmitter:sodium symporter activity
ACT74_RS00770	COG4964	Belongs to the GSP D family
ACT74_RS00795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACT74_RS00805	COG1444	tRNA N-acetyltransferase activity
ACT74_RS00810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACT74_RS00820	COG1126	abc transporter atp-binding protein
ACT74_RS00825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACT74_RS00830	COG4215	(ABC) transporter
ACT74_RS00835	COG4160	amino acid transport
ACT74_RS00840	COG1966	Carbon starvation protein
ACT74_RS00855	COG3116	cell division
ACT74_RS00860	COG0768	penicillin binding
ACT74_RS00870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACT74_RS00880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACT74_RS00890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACT74_RS00905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACT74_RS00910	COG0849	cell division
ACT74_RS00915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACT74_RS00925	COG1605	Chorismate mutase
ACT74_RS00925	COG0077	Prephenate dehydratase
ACT74_RS00930	COG0326	Molecular chaperone. Has ATPase activity
ACT74_RS00935	COG1393	Belongs to the ArsC family
ACT74_RS00945	COG1876	peptidase activity
ACT74_RS00950	COG0494	nUDIX hydrolase
ACT74_RS00955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ACT74_RS00990	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ACT74_RS01000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACT74_RS01005	COG1053	succinate dehydrogenase
ACT74_RS01015	COG1120	ATPase activity
ACT74_RS01020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACT74_RS01025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACT74_RS01030	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ACT74_RS01035	COG1408	metallophosphoesterase
ACT74_RS01045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACT74_RS01050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACT74_RS01070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACT74_RS01080	COG0741	lytic transglycosylase activity
ACT74_RS01085	COG2350	Protein conserved in bacteria
ACT74_RS01090	COG1607	acyl-coa hydrolase
ACT74_RS01105	COG3047	cAMP biosynthetic process
ACT74_RS01110	COG0497	DNA recombination
ACT74_RS01120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACT74_RS01130	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACT74_RS01130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACT74_RS01135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACT74_RS01140	COG5002	protein histidine kinase activity
ACT74_RS01140	COG0784	Response regulator, receiver
ACT74_RS01140	COG2198	Histidine kinase
ACT74_RS01145	COG4211	Belongs to the binding-protein-dependent transport system permease family
ACT74_RS01155	COG1879	ABC-type sugar transport system periplasmic component
ACT74_RS01160	COG1609	Transcriptional regulator
ACT74_RS01165	COG1085	galactose-1-phosphate uridylyltransferase
ACT74_RS01170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACT74_RS01175	COG2017	converts alpha-aldose to the beta-anomer
ACT74_RS01190	COG0471	metal ion transport
ACT74_RS01195	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
ACT74_RS01195	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ACT74_RS01200	COG3051	citrate lyase alpha subunit
ACT74_RS01205	COG2301	Belongs to the HpcH HpaI aldolase family
ACT74_RS01215	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ACT74_RS01220	COG4535	Mg2 and Co2 transporter CorC
ACT74_RS01240	COG0105	UTP biosynthetic process
ACT74_RS01250	COG0489	protein tyrosine kinase activity
ACT74_RS01255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACT74_RS01255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACT74_RS01260	COG2975	iron-sulfur cluster assembly
ACT74_RS01265	COG0633	Ferredoxin
ACT74_RS01270	COG0443	Heat shock 70 kDa protein
ACT74_RS01285	COG0822	iron-sulfur transferase activity
ACT74_RS01295	COG1959	2 iron, 2 sulfur cluster binding
ACT74_RS01300	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ACT74_RS01325	COG1840	ABC-type Fe3 transport system, periplasmic component
ACT74_RS01330	COG1840	ABC-type Fe3 transport system, periplasmic component
ACT74_RS01380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACT74_RS01385	COG1530	ribonuclease E activity
ACT74_RS01390	COG2999	glutathione oxidoreductase activity
ACT74_RS01395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACT74_RS01450	COG3021	interspecies interaction between organisms
ACT74_RS01490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACT74_RS01495	COG0626	cystathionine gamma-synthase activity
ACT74_RS01515	COG0484	heat shock protein binding
ACT74_RS01520	COG0443	Heat shock 70 kDa protein
ACT74_RS01525	COG5339	Protein conserved in bacteria
ACT74_RS01535	COG3102	Protein conserved in bacteria
ACT74_RS01540	COG3133	Outer membrane lipoprotein
ACT74_RS01545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACT74_RS01550	COG2890	protein-(glutamine-N5) methyltransferase activity
ACT74_RS01560	COG0791	NLP P60 protein
ACT74_RS01565	COG3100	YcgL domain-containing protein
ACT74_RS01580	COG2062	phosphohistidine phosphatase, SixA
ACT74_RS01590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACT74_RS01595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACT74_RS01600	COG2801	Transposase and inactivated derivatives
ACT74_RS01615	COG2963	transposase activity
ACT74_RS01620	COG0517	IMP dehydrogenase activity
ACT74_RS01620	COG0516	GMP reductase activity
ACT74_RS01625	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ACT74_RS01625	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ACT74_RS01655	COG4172	Belongs to the ABC transporter superfamily
ACT74_RS01660	COG4172	Belongs to the ABC transporter superfamily
ACT74_RS01665	COG4171	peptide transport system, permease
ACT74_RS01670	COG4168	peptide transport system, permease
ACT74_RS01675	COG4166	transmembrane transport
ACT74_RS01680	COG3106	COG3106 Predicted ATPase
ACT74_RS01690	COG3283	Transcriptional regulator of aromatic amino acids metabolism
ACT74_RS01695	COG1923	regulation of RNA biosynthetic process
ACT74_RS01705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACT74_RS01710	COG1388	LysM domain
ACT74_RS01710	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACT74_RS01715	COG0802	atpase or kinase
ACT74_RS01725	COG2246	polysaccharide biosynthetic process
ACT74_RS01735	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACT74_RS01745	COG2194	sulfuric ester hydrolase activity
ACT74_RS01765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT74_RS01770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACT74_RS01775	COG2190	(PTS) system
ACT74_RS01780	COG0339	signal peptide processing
ACT74_RS01785	COG2832	Protein of unknown function (DUF454)
ACT74_RS01790	COG4166	transmembrane transport
ACT74_RS01795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACT74_RS01805	COG0512	Glutamine amidotransferase of anthranilate synthase
ACT74_RS01810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACT74_RS01815	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACT74_RS01825	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACT74_RS01830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACT74_RS01835	COG0305	Participates in initiation and elongation during chromosome replication
ACT74_RS01845	COG0166	Belongs to the GPI family
ACT74_RS01850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACT74_RS01860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACT74_RS01865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACT74_RS01870	COG1280	lysine exporter protein (LysE YggA)
ACT74_RS01880	COG0633	Ferredoxin
ACT74_RS01890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACT74_RS01900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACT74_RS01910	COG1840	ABC-type Fe3 transport system, periplasmic component
ACT74_RS01920	COG3842	ATPase activity
ACT74_RS01925	COG0366	Alpha amylase catalytic
ACT74_RS01930	COG3833	ABC-type maltose transport systems, permease component
ACT74_RS01940	COG2182	Extracellular solute-binding protein
ACT74_RS01945	COG3842	ATPase activity
ACT74_RS01950	COG4580	involved in the transport of maltose and maltodextrins
ACT74_RS01960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACT74_RS01965	COG0303	'Molybdopterin
ACT74_RS01975	COG2027	D-alanyl-D-alanine carboxypeptidase
ACT74_RS01980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACT74_RS01985	COG1534	Rna-binding protein
ACT74_RS01990	COG3657	addiction module killer protein
ACT74_RS01995	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACT74_RS02000	COG0307	riboflavin synthase, alpha
ACT74_RS02010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACT74_RS02015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACT74_RS02020	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACT74_RS02025	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ACT74_RS02030	COG3842	ATPase activity
ACT74_RS02050	COG2855	membrane
ACT74_RS02055	COG4953	penicillin-binding protein 1C
ACT74_RS02060	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ACT74_RS02085	COG3623	hexulose-6-phosphate isomerase
ACT74_RS02090	COG0235	Class ii aldolase
ACT74_RS02095	COG0814	amino acid
ACT74_RS02105	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACT74_RS02110	COG0778	Nitroreductase
ACT74_RS02120	COG2268	Band 7 protein
ACT74_RS02125	COG0114	fumarate hydratase activity
ACT74_RS02130	COG2927	DNA polymerase III (CHI subunit)
ACT74_RS02160	COG3550	peptidyl-serine autophosphorylation
ACT74_RS02170	COG2814	Major facilitator Superfamily
ACT74_RS02175	COG1566	PFAM secretion protein HlyD family protein
ACT74_RS02180	COG0783	Belongs to the Dps family
ACT74_RS02190	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACT74_RS02195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACT74_RS02200	COG0602	queuosine metabolic process
ACT74_RS02205	COG0720	synthase
ACT74_RS02210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACT74_RS02220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACT74_RS02225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACT74_RS02230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACT74_RS02235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACT74_RS02240	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
ACT74_RS02245	COG0310	cobalt ion transport
ACT74_RS02250	COG0310	cobalt ion transport
ACT74_RS02255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ACT74_RS02260	COG1122	ATPase activity
ACT74_RS02265	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACT74_RS02270	COG0409	Hydrogenase expression formation protein
ACT74_RS02275	COG0309	Hydrogenase expression formation protein (HypE)
ACT74_RS02290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACT74_RS02295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ACT74_RS02300	COG0795	lipopolysaccharide-transporting ATPase activity
ACT74_RS02305	COG0795	lipopolysaccharide-transporting ATPase activity
ACT74_RS02310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACT74_RS02315	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ACT74_RS02320	COG4149	molybdate abc transporter
ACT74_RS02325	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACT74_RS02330	COG2005	Transcriptional regulator
ACT74_RS02335	COG0471	metal ion transport
ACT74_RS02345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACT74_RS02350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACT74_RS02350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACT74_RS02355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACT74_RS02365	COG0583	DNA-binding transcription factor activity
ACT74_RS02370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACT74_RS02380	COG0039	L-malate dehydrogenase activity
ACT74_RS02385	COG1438	arginine binding
ACT74_RS02390	COG1090	epimerase
ACT74_RS02395	COG4657	Part of a membrane complex involved in electron transport
ACT74_RS02425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACT74_RS02430	COG0733	neurotransmitter:sodium symporter activity
ACT74_RS02435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACT74_RS02445	COG0739	heme binding
ACT74_RS02450	COG4604	ABC transporter, ATP-binding protein
ACT74_RS02455	COG4605	iron ion homeostasis
ACT74_RS02460	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACT74_RS02465	COG4607	ABC-type enterochelin transport system periplasmic component
ACT74_RS02470	COG0737	Belongs to the 5'-nucleotidase family
ACT74_RS02480	COG3111	PFAM Bacterial OB fold (BOF) protein
ACT74_RS02505	COG3392	D12 class N6 adenine-specific DNA methyltransferase
ACT74_RS02515	COG0642	Histidine kinase
ACT74_RS02520	COG0405	Gamma-glutamyltransferase
ACT74_RS02535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACT74_RS02540	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ACT74_RS02545	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
ACT74_RS02580	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACT74_RS02585	COG1518	maintenance of DNA repeat elements
ACT74_RS02600	COG4143	(ABC) transporter
ACT74_RS02605	COG1178	ABC-type Fe3 transport system permease component
ACT74_RS02610	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ACT74_RS02620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACT74_RS02625	COG3105	Protein conserved in bacteria
ACT74_RS02630	COG1944	ATP diphosphatase activity
ACT74_RS02640	COG3422	double-strand break repair
ACT74_RS02655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACT74_RS02665	COG1940	carbohydrate kinase activity
ACT74_RS02665	COG1846	Transcriptional regulator
ACT74_RS02690	COG0563	adenylate kinase activity
ACT74_RS02695	COG2814	Major facilitator Superfamily
ACT74_RS02700	COG0375	protein maturation
ACT74_RS02705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACT74_RS02710	COG3152	Membrane
ACT74_RS02715	COG2252	PERMEase
ACT74_RS02730	COG0825	malonyl-CoA metabolic process
ACT74_RS02735	COG2351	hydroxyisourate hydrolase activity
ACT74_RS02795	COG1598	PFAM Uncharacterised protein family UPF0150
ACT74_RS02805	COG5301	cellulose 1,4-beta-cellobiosidase activity
ACT74_RS02815	COG0582	viral genome integration into host DNA
ACT74_RS02825	COG3041	Addiction module toxin RelE StbE family
ACT74_RS02830	COG3077	Addiction module antitoxin, RelB DinJ family
ACT74_RS02835	COG3069	C4-dicarboxylate transmembrane transporter activity
ACT74_RS02850	COG0195	Participates in both transcription termination and antitermination
ACT74_RS02875	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACT74_RS02900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ACT74_RS02905	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ACT74_RS02910	COG3177	Filamentation induced by cAMP protein fic
ACT74_RS02920	COG3842	ATPase activity
ACT74_RS02925	COG1175	transmembrane transport
ACT74_RS02930	COG0395	ABC-type sugar transport system, permease component
ACT74_RS02940	COG0322	excinuclease ABC activity
ACT74_RS02950	COG2835	tetraacyldisaccharide 4'-kinase activity
ACT74_RS02955	COG1663	tetraacyldisaccharide 4'-kinase activity
ACT74_RS02965	COG0658	competence protein
ACT74_RS02965	COG2333	competence protein COMEC
ACT74_RS02970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACT74_RS02975	COG0617	tRNA 3'-terminal CCA addition
ACT74_RS02980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACT74_RS02990	COG0857	belongs to the CobB CobQ family
ACT74_RS02990	COG0280	phosphate acetyltransferase
ACT74_RS02995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACT74_RS03000	COG3092	negative regulation of chromosome organization
ACT74_RS03005	COG1286	toxin biosynthetic process
ACT74_RS03010	COG1640	4-alpha-glucanotransferase
ACT74_RS03015	COG0058	SHG alpha-glucan phosphorylase activity
ACT74_RS03020	COG2909	trisaccharide binding
ACT74_RS03030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACT74_RS03035	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACT74_RS03040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACT74_RS03045	COG0778	Nitroreductase
ACT74_RS03050	COG0616	signal peptide processing
ACT74_RS03055	COG1605	Chorismate mutase
ACT74_RS03055	COG0287	Prephenate dehydrogenase
ACT74_RS03060	COG0287	Prephenate dehydrogenase
ACT74_RS03060	COG1605	Chorismate mutase
ACT74_RS03065	COG0009	L-threonylcarbamoyladenylate synthase
ACT74_RS03075	COG0583	DNA-binding transcription factor activity
ACT74_RS03085	COG3099	Belongs to the UPF0263 family
ACT74_RS03095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACT74_RS03100	COG2949	membrane
ACT74_RS03120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACT74_RS03125	COG0785	Cytochrome C biogenesis protein
ACT74_RS03130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACT74_RS03130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACT74_RS03135	COG0288	reversible hydration of carbon dioxide
ACT74_RS03140	COG2823	Periplasmic or secreted lipoprotein
ACT74_RS03145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACT74_RS03150	COG0792	nuclease activity
ACT74_RS03160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACT74_RS03170	COG1252	NADH dehydrogenase
ACT74_RS03180	COG0616	signal peptide processing
ACT74_RS03185	COG2885	chlorophyll binding
ACT74_RS03185	COG3047	cAMP biosynthetic process
ACT74_RS03220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACT74_RS03225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACT74_RS03230	COG3684	Belongs to the aldolase LacD family
ACT74_RS03240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT74_RS03245	COG3414	Phosphotransferase system galactitol-specific IIB component
ACT74_RS03250	COG3775	system Galactitol-specific IIC component
ACT74_RS03260	COG1349	DNA-binding transcription factor activity
ACT74_RS03270	COG0142	geranyltranstransferase activity
ACT74_RS03285	COG0285	dihydrofolate synthase activity
ACT74_RS03290	COG0406	alpha-ribazole phosphatase activity
ACT74_RS03295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACT74_RS03300	COG2431	L-lysine efflux transmembrane transporter activity
ACT74_RS03305	COG0564	pseudouridine synthase activity
ACT74_RS03315	COG2824	Alkylphosphonate utilization operon protein PhnA
ACT74_RS03345	COG1538	Outer membrane efflux protein
ACT74_RS03350	COG1136	(ABC) transporter
ACT74_RS03350	COG0577	efflux transmembrane transporter activity
ACT74_RS03355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACT74_RS03380	COG1523	belongs to the glycosyl hydrolase 13 family
ACT74_RS03395	COG0058	SHG alpha-glucan phosphorylase activity
ACT74_RS03400	COG0586	Pfam SNARE associated Golgi protein
ACT74_RS03405	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACT74_RS03415	COG1686	Belongs to the peptidase S11 family
ACT74_RS03420	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ACT74_RS03425	COG0204	Acyl-transferase
ACT74_RS03425	COG0318	PFAM AMP-dependent synthetase and ligase
ACT74_RS03430	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ACT74_RS03435	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ACT74_RS03440	COG0697	spore germination
ACT74_RS03445	COG2925	Exonuclease
ACT74_RS03455	COG2801	Transposase and inactivated derivatives
ACT74_RS03470	COG1528	Iron-storage protein
ACT74_RS03475	COG1528	Iron-storage protein
ACT74_RS03480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACT74_RS03485	COG0589	response to stress
ACT74_RS03490	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
ACT74_RS03500	COG0613	PHP domain protein
ACT74_RS03505	COG0167	dihydroorotate dehydrogenase activity
ACT74_RS03510	COG0308	aminopeptidase N
ACT74_RS03515	COG1448	Aminotransferase
ACT74_RS03525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACT74_RS03530	COG0842	Transport permease protein
ACT74_RS03530	COG1129	ABC transporter
ACT74_RS03535	COG0842	Transport permease protein
ACT74_RS03545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACT74_RS03550	COG1120	ATPase activity
ACT74_RS03565	COG1120	ATPase activity
ACT74_RS03570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACT74_RS03575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACT74_RS03585	COG4774	siderophore transport
ACT74_RS03600	COG0791	NLP P60 protein
ACT74_RS03615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACT74_RS03630	COG0517	IMP dehydrogenase activity
ACT74_RS03630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACT74_RS03635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACT74_RS03640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACT74_RS03645	COG0512	Glutamine amidotransferase of anthranilate synthase
ACT74_RS03650	COG1942	4-Oxalocrotonate Tautomerase
ACT74_RS03655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACT74_RS03665	COG3093	addiction module antidote protein HigA
ACT74_RS03670	COG0135	phosphoribosylanthranilate isomerase activity
ACT74_RS03670	COG0134	indole-3-glycerol-phosphate synthase activity
ACT74_RS03675	COG0298	carbon dioxide binding
ACT74_RS03685	COG3630	sodium ion export across plasma membrane
ACT74_RS03700	COG1629	transport
ACT74_RS03700	COG4771	TonB-dependent receptor
ACT74_RS03710	COG4221	oxidoreductase activity
ACT74_RS03715	COG0133	tryptophan synthase activity
ACT74_RS03725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACT74_RS03735	COG0469	pyruvate kinase activity
ACT74_RS03750	COG1879	ABC-type sugar transport system periplasmic component
ACT74_RS03770	COG2390	Transcriptional regulator
ACT74_RS03780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACT74_RS03785	COG1940	carbohydrate kinase activity
ACT74_RS03795	COG2969	positive regulation of protein catabolic process
ACT74_RS03805	COG0314	molybdopterin synthase activity
ACT74_RS03810	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ACT74_RS03820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACT74_RS03845	COG3005	denitrification pathway
ACT74_RS03850	COG0243	molybdopterin cofactor binding
ACT74_RS03855	COG2315	Protein conserved in bacteria
ACT74_RS03860	COG0471	metal ion transport
ACT74_RS03875	COG0101	tRNA pseudouridine synthase activity
ACT74_RS03895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACT74_RS03900	COG1074	ATP-dependent DNA helicase activity
ACT74_RS03905	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ACT74_RS03915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACT74_RS03920	COG1067	ATP-dependent peptidase activity
ACT74_RS03930	COG1278	Cold shock
ACT74_RS03935	COG3140	Belongs to the UPF0181 family
ACT74_RS03945	COG3098	single-species biofilm formation
ACT74_RS03950	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ACT74_RS03955	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACT74_RS03955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACT74_RS03985	COG3101	peptidyl-lysine hydroxylation
ACT74_RS03990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACT74_RS04000	COG0788	formyltetrahydrofolate deformylase activity
ACT74_RS04005	COG2916	Histone family protein nucleoid-structuring protein H-NS
ACT74_RS04010	COG1757	Na H antiporter
ACT74_RS04045	COG3161	chorismate lyase activity
ACT74_RS04055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACT74_RS04060	COG1758	RNA polymerase activity
ACT74_RS04070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACT74_RS04080	COG2867	negative regulation of translational initiation
ACT74_RS04090	COG2850	peptidyl-arginine hydroxylation
ACT74_RS04105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT74_RS04110	COG1137	ATPase activity
ACT74_RS04115	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ACT74_RS04120	COG3117	lipopolysaccharide transmembrane transporter activity
ACT74_RS04125	COG1127	ABC transporter
ACT74_RS04130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACT74_RS04135	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ACT74_RS04140	COG2854	intermembrane phospholipid transfer
ACT74_RS04145	COG3113	response to antibiotic
ACT74_RS04150	COG5007	Belongs to the BolA IbaG family
ACT74_RS04170	COG0463	Glycosyl transferase, family 2
ACT74_RS04180	COG3691	Protein conserved in bacteria
ACT74_RS04185	COG2067	long-chain fatty acid transport protein
ACT74_RS04190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACT74_RS04200	COG0861	Integral membrane protein TerC family
ACT74_RS04210	COG2801	Transposase and inactivated derivatives
ACT74_RS04220	COG1217	gtp-binding protein TYPA
ACT74_RS04230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACT74_RS04235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACT74_RS04250	COG0517	IMP dehydrogenase activity
ACT74_RS04250	COG1125	glycine betaine transport
ACT74_RS04255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACT74_RS04265	COG0527	aspartate kinase activity
ACT74_RS04265	COG0460	homoserine dehydrogenase
ACT74_RS04280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACT74_RS04285	COG2091	lysine biosynthetic process via aminoadipic acid
ACT74_RS04290	COG0330	HflC and HflK could
ACT74_RS04295	COG0330	HflC and HflK could
ACT74_RS04300	COG1555	photosystem II stabilization
ACT74_RS04305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACT74_RS04315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACT74_RS04320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACT74_RS04325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACT74_RS04330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACT74_RS04335	COG0800	Aldolase
ACT74_RS04345	COG1028	Short-chain dehydrogenase reductase Sdr
ACT74_RS04350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACT74_RS04360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACT74_RS04375	COG2186	Transcriptional regulator
ACT74_RS04395	COG0659	secondary active sulfate transmembrane transporter activity
ACT74_RS04405	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACT74_RS04420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACT74_RS04425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACT74_RS04445	COG3115	cell septum assembly
ACT74_RS04455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACT74_RS04460	COG1573	uracil-dna glycosylase
ACT74_RS04465	COG0012	GTP binding
ACT74_RS04470	COG0193	aminoacyl-tRNA hydrolase activity
ACT74_RS04530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACT74_RS04535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACT74_RS04545	COG0024	Methionine aminopeptidase
ACT74_RS04550	COG0316	Belongs to the HesB IscA family
ACT74_RS04560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACT74_RS04565	COG0672	)-iron permease
ACT74_RS04580	COG0577	efflux transmembrane transporter activity
ACT74_RS04590	COG1136	(ABC) transporter
ACT74_RS04590	COG0577	efflux transmembrane transporter activity
ACT74_RS04595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACT74_RS04605	COG0546	phosphoglycolate phosphatase activity
ACT74_RS04610	COG3385	transposase activity
ACT74_RS04625	COG1643	Atp-dependent helicase
ACT74_RS04630	COG2363	Small membrane protein
ACT74_RS04650	COG0247	lactate metabolic process
ACT74_RS04650	COG0277	FAD linked oxidase domain protein
ACT74_RS04665	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ACT74_RS04670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ACT74_RS04675	COG0363	glucosamine-6-phosphate deaminase activity
ACT74_RS04680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACT74_RS04685	COG1737	Transcriptional regulator
ACT74_RS04695	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ACT74_RS04700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACT74_RS04710	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
ACT74_RS04715	COG2190	(PTS) system
ACT74_RS04715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACT74_RS04715	COG1263	PTS System
ACT74_RS04735	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ACT74_RS04740	COG3683	transport system, periplasmic component
ACT74_RS04745	COG0488	(ABC) transporter
ACT74_RS04755	COG0187	DNA topoisomerase II activity
ACT74_RS04760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACT74_RS04765	COG0625	glutathione transferase activity
ACT74_RS04770	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
ACT74_RS04780	COG0251	oxidation-reduction process
ACT74_RS04790	COG0463	Glycosyl transferase, family 2
ACT74_RS04800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACT74_RS04810	COG1560	Kdo2-lipid A biosynthetic process
ACT74_RS04815	COG0730	response to heat
ACT74_RS04820	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ACT74_RS04825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACT74_RS04830	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ACT74_RS04830	COG3264	Mechanosensitive ion channel
ACT74_RS04835	COG0318	PFAM AMP-dependent synthetase and ligase
ACT74_RS04840	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ACT74_RS04845	COG0596	Alpha beta hydrolase
ACT74_RS04850	COG0716	FMN binding
ACT74_RS04855	COG0735	belongs to the Fur family
ACT74_RS04860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACT74_RS04865	COG3094	Invasion gene expression up-regulator, SirB
ACT74_RS04870	COG0023	Translation Initiation Factor
ACT74_RS04880	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ACT74_RS04885	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ACT74_RS04895	COG0539	negative regulation of cytoplasmic translation
ACT74_RS04905	COG2990	Protein conserved in bacteria
ACT74_RS04915	COG0612	Peptidase, M16
ACT74_RS04920	COG1687	branched-chain amino acid
ACT74_RS04925	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACT74_RS04930	COG0583	DNA-binding transcription factor activity
ACT74_RS04960	COG2920	part of a sulfur-relay system
ACT74_RS04970	COG1121	(ABC) transporter
ACT74_RS04975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACT74_RS04980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACT74_RS05000	COG3304	Inner membrane component domain
ACT74_RS05005	COG1289	transmembrane transporter activity
ACT74_RS05020	COG3958	Transketolase
ACT74_RS05025	COG3959	Transketolase, thiamine diphosphate binding domain
ACT74_RS05050	COG0488	(ABC) transporter
ACT74_RS05060	COG1346	cytolysis
ACT74_RS05075	COG1525	nuclease
ACT74_RS05080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACT74_RS05085	COG2166	iron-sulfur cluster assembly
ACT74_RS05090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACT74_RS05090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACT74_RS05095	COG1560	Kdo2-lipid A biosynthetic process
ACT74_RS05100	COG3381	protein complex oligomerization
ACT74_RS05105	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACT74_RS05115	COG0330	HflC and HflK could
ACT74_RS05140	COG1858	cytochrome C peroxidase
ACT74_RS05145	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ACT74_RS05150	COG0318	PFAM AMP-dependent synthetase and ligase
ACT74_RS05155	COG3065	identical protein binding
ACT74_RS05160	COG1214	PFAM Peptidase M22, glycoprotease
ACT74_RS05165	COG1199	ATP-dependent helicase activity
ACT74_RS05170	COG0676	glucose-6-phosphate 1-epimerase activity
ACT74_RS05175	COG3118	belongs to the thioredoxin family
ACT74_RS05180	COG0492	ferredoxin-NADP+ reductase activity
ACT74_RS05185	COG4988	ABC transporter
ACT74_RS05190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ACT74_RS05200	COG1946	Acyl-CoA thioesterase
ACT74_RS05205	COG0515	serine threonine protein kinase
ACT74_RS05220	COG1940	carbohydrate kinase activity
ACT74_RS05225	COG0671	phosphoesterase, PA-phosphatase related
ACT74_RS05245	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ACT74_RS05250	COG0708	Exodeoxyribonuclease III
ACT74_RS05275	COG1216	Glycosyl transferase, family 2
ACT74_RS05280	COG2246	polysaccharide biosynthetic process
ACT74_RS05300	COG0463	Glycosyl transferase, family 2
ACT74_RS05335	COG2951	lytic endotransglycosylase activity
ACT74_RS05340	COG1216	Glycosyl transferase, family 2
ACT74_RS05345	COG1216	Glycosyl transferase, family 2
ACT74_RS05355	COG3306	glycosyltransferase involved in LPS biosynthesis
ACT74_RS05365	COG5039	Polysaccharide pyruvyl transferase
ACT74_RS05370	COG2161	toxin-antitoxin pair type II binding
ACT74_RS05375	COG4115	mRNA cleavage
ACT74_RS05380	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACT74_RS05385	COG1793	dna ligase
ACT74_RS05390	COG0210	DNA helicase
ACT74_RS05395	COG2610	gluconate transmembrane transporter activity
ACT74_RS05400	COG3265	gluconokinase activity
ACT74_RS05405	COG1609	Transcriptional regulator
ACT74_RS05425	COG0437	4 iron, 4 sulfur cluster binding
ACT74_RS05430	COG2864	formate dehydrogenase
ACT74_RS05435	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACT74_RS05440	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACT74_RS05445	COG0651	ATP synthesis coupled electron transport
ACT74_RS05450	COG0650	Formate hydrogenlyase subunit 4
ACT74_RS05455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACT74_RS05460	COG4237	Hydrogenase 4 membrane
ACT74_RS05465	COG0651	ATP synthesis coupled electron transport
ACT74_RS05470	COG3261	NADH dehydrogenase
ACT74_RS05470	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ACT74_RS05475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACT74_RS05480	COG3260	NADH ubiquinone oxidoreductase 20
ACT74_RS05490	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ACT74_RS05495	COG3383	formate dehydrogenase (NAD+) activity
ACT74_RS05500	COG3383	formate dehydrogenase (NAD+) activity
ACT74_RS05505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACT74_RS05515	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACT74_RS05520	COG0567	Dehydrogenase, E1 component
ACT74_RS05525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACT74_RS05530	COG3108	Peptidase M15
ACT74_RS05535	COG2989	Protein conserved in bacteria
ACT74_RS05540	COG0793	Belongs to the peptidase S41A family
ACT74_RS05550	COG2995	paraquat-inducible protein a
ACT74_RS05555	COG3008	intermembrane lipid transfer
ACT74_RS05565	COG3842	ATPase activity
ACT74_RS05570	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACT74_RS05575	COG1177	transmembrane transport
ACT74_RS05580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACT74_RS05595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ACT74_RS05600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACT74_RS05615	COG1522	sequence-specific DNA binding
ACT74_RS05620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACT74_RS05625	COG3025	triphosphatase activity
ACT74_RS05630	COG1392	Phosphate transport regulator
ACT74_RS05635	COG0306	phosphate transporter
ACT74_RS05640	COG4991	sh3 domain protein
ACT74_RS05645	COG0617	tRNA 3'-terminal CCA addition
ACT74_RS05650	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ACT74_RS05655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACT74_RS05670	COG1620	l-lactate permease
ACT74_RS05705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACT74_RS05710	COG0328	RNA-DNA hybrid ribonuclease activity
ACT74_RS05715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACT74_RS05735	COG2026	Addiction module toxin, RelE StbE family
ACT74_RS05750	COG0826	peptidase U32
ACT74_RS05760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACT74_RS05770	COG1862	Preprotein translocase
ACT74_RS05775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACT74_RS05780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACT74_RS05790	COG1012	belongs to the aldehyde dehydrogenase family
ACT74_RS05790	COG1454	alcohol dehydrogenase
ACT74_RS05795	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACT74_RS05800	COG1129	ABC transporter
ACT74_RS05815	COG0673	inositol 2-dehydrogenase activity
ACT74_RS05825	COG2271	Major facilitator Superfamily
ACT74_RS05835	COG3718	enzyme involved in inositol metabolism
ACT74_RS05845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACT74_RS05850	COG3962	Belongs to the TPP enzyme family
ACT74_RS05860	COG0673	inositol 2-dehydrogenase activity
ACT74_RS05865	COG3722	fumarate hydratase activity
ACT74_RS05870	COG0246	Mannitol dehydrogenase
ACT74_RS05880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACT74_RS05885	COG2274	protein secretion by the type I secretion system
ACT74_RS05890	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ACT74_RS05895	COG2994	toxin metabolic process
ACT74_RS05905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACT74_RS05920	COG2813	Specifically methylates the guanine in position
ACT74_RS05925	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ACT74_RS05930	COG0456	acetyltransferase
ACT74_RS05935	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ACT74_RS05950	COG2165	general secretion pathway protein
ACT74_RS05980	COG3064	Membrane
ACT74_RS05985	COG0848	biopolymer transport protein
ACT74_RS05990	COG0811	peptide transport
ACT74_RS05995	COG0824	Thioesterase
ACT74_RS06005	COG1294	oxidase, subunit
ACT74_RS06010	COG1271	oxidase subunit
ACT74_RS06035	COG0641	radical SAM
ACT74_RS06040	COG0217	transcriptional regulatory protein
ACT74_RS06045	COG0494	nUDIX hydrolase
ACT74_RS06055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACT74_RS06060	COG1755	Isoprenylcysteine carboxyl methyltransferase
ACT74_RS06075	COG2271	Major facilitator Superfamily
ACT74_RS06085	COG0346	lactoylglutathione lyase activity
ACT74_RS06090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACT74_RS06095	COG2056	Na+-H+ antiporter family
ACT74_RS06115	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACT74_RS06120	COG0142	geranyltranstransferase activity
ACT74_RS06135	COG0697	spore germination
ACT74_RS06140	COG0697	spore germination
ACT74_RS06145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACT74_RS06155	COG4166	transmembrane transport
ACT74_RS06160	COG0601	transmembrane transport
ACT74_RS06165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACT74_RS06170	COG0444	Belongs to the ABC transporter superfamily
ACT74_RS06175	COG4608	Belongs to the ABC transporter superfamily
ACT74_RS06185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACT74_RS06195	COG1611	Belongs to the LOG family
ACT74_RS06205	COG2259	Doxx family
ACT74_RS06215	COG1530	ribonuclease E activity
ACT74_RS06230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACT74_RS06235	COG0626	cystathionine gamma-synthase activity
ACT74_RS06265	COG2860	membrane
ACT74_RS06280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACT74_RS06290	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ACT74_RS06295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACT74_RS06300	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ACT74_RS06305	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
ACT74_RS06315	COG0560	Phosphoserine phosphatase
ACT74_RS06330	COG0728	peptidoglycan biosynthetic process
ACT74_RS06335	COG0196	riboflavin kinase activity
ACT74_RS06345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACT74_RS06360	COG4974	Belongs to the 'phage' integrase family
ACT74_RS06365	COG2814	Major facilitator Superfamily
ACT74_RS06370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACT74_RS06375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACT74_RS06390	COG3061	Opacity-associated protein A
ACT74_RS06390	COG3266	domain, Protein
ACT74_RS06395	COG1509	lysine 2,3-aminomutase activity
ACT74_RS06405	COG3033	Beta-eliminating lyase
ACT74_RS06415	COG2964	Protein conserved in bacteria
ACT74_RS06420	COG5413	integral membrane protein
ACT74_RS06430	COG0204	Acyl-transferase
ACT74_RS06440	COG0697	spore germination
ACT74_RS06445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ACT74_RS06450	COG1882	Formate acetyltransferase
ACT74_RS06455	COG2116	formate transmembrane transporter activity
ACT74_RS06460	COG0537	adenosine 5'-monophosphoramidase activity
ACT74_RS06495	COG3022	response to hydroperoxide
ACT74_RS06515	COG0681	Belongs to the peptidase S26 family
ACT74_RS06550	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACT74_RS06555	COG0592	DNA-directed DNA polymerase activity
ACT74_RS06565	COG2226	methyltransferase
ACT74_RS06580	COG2801	Transposase and inactivated derivatives
ACT74_RS06590	COG0281	malic enzyme
ACT74_RS06595	COG2081	HI0933 family
ACT74_RS06600	COG3088	subunit of a heme lyase
ACT74_RS06600	COG4235	cytochrome complex assembly
ACT74_RS06605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACT74_RS06610	COG1138	Cytochrome C-type biogenesis protein
ACT74_RS06615	COG3301	Polysulphide reductase, NrfD
ACT74_RS06620	COG0437	4 iron, 4 sulfur cluster binding
ACT74_RS06625	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ACT74_RS06660	COG1138	Cytochrome C-type biogenesis protein
ACT74_RS06670	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACT74_RS06675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACT74_RS06680	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACT74_RS06685	COG4133	protoheme IX ABC transporter activity
ACT74_RS06690	COG2814	Major facilitator Superfamily
ACT74_RS06700	COG0281	malic enzyme
ACT74_RS06700	COG0280	phosphate acetyltransferase
ACT74_RS06715	COG2321	neutral zinc metallopeptidase
ACT74_RS06730	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACT74_RS06735	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ACT74_RS06740	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ACT74_RS06755	COG0436	Aminotransferase
ACT74_RS06765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ACT74_RS06770	COG2267	carboxylic ester hydrolase activity
ACT74_RS06785	COG3091	SprT-like family
ACT74_RS06790	COG0814	amino acid
ACT74_RS06795	COG1760	l-serine dehydratase
ACT74_RS06800	COG0252	asparaginase activity
ACT74_RS06810	COG3063	Type IV pilus biogenesis stability protein PilW
ACT74_RS06815	COG1426	Protein conserved in bacteria
ACT74_RS06830	COG2976	Protein conserved in bacteria
ACT74_RS06840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACT74_RS06845	COG2233	PERMEase
ACT74_RS06850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACT74_RS06855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACT74_RS06860	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACT74_RS06860	COG2918	glutathione biosynthetic process
ACT74_RS06865	COG2194	sulfuric ester hydrolase activity
ACT74_RS06870	COG0740	serine-type endopeptidase activity
ACT74_RS06890	COG3739	integral membrane protein
ACT74_RS06895	COG2217	Heavy metal translocating P-type atpase
ACT74_RS06900	COG2608	mercury ion transmembrane transporter activity
ACT74_RS06905	COG0789	Transcriptional regulator
ACT74_RS06910	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ACT74_RS06920	COG1720	tRNA m6t6A37 methyltransferase activity
ACT74_RS06925	COG1575	Belongs to the MenA family. Type 1 subfamily
ACT74_RS06935	COG0471	metal ion transport
ACT74_RS06940	COG3028	Belongs to the UPF0307 family
ACT74_RS06945	COG0312	modulator of DNA gyrase
ACT74_RS06950	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ACT74_RS06955	COG1929	Belongs to the glycerate kinase type-1 family
ACT74_RS06960	COG2610	gluconate transmembrane transporter activity
ACT74_RS06965	COG3835	regulator
ACT74_RS06975	COG0513	Belongs to the DEAD box helicase family
ACT74_RS06980	COG4785	May be involved in cell division
ACT74_RS06990	COG2731	YhcH YjgK YiaL family protein
ACT74_RS06995	COG3023	N-Acetylmuramoyl-L-alanine amidase
ACT74_RS07000	COG4969	Belongs to the N-Me-Phe pilin family
ACT74_RS07010	COG1459	type II secretion system
ACT74_RS07020	COG0237	dephospho-CoA kinase activity
ACT74_RS07020	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ACT74_RS07025	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ACT74_RS07035	COG1115	amino acid carrier protein
ACT74_RS07040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACT74_RS07065	COG2184	nucleotidyltransferase activity
ACT74_RS07070	COG4145	pantothenate transmembrane transporter activity
ACT74_RS07075	COG3924	membrane
ACT74_RS07080	COG4783	chaperone-mediated protein folding
ACT74_RS07090	COG0439	Biotin carboxylase
ACT74_RS07095	COG0511	ligase activity, forming carbon-carbon bonds
ACT74_RS07120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ACT74_RS07130	COG0456	acetyltransferase
ACT74_RS07135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACT74_RS07145	COG3078	GTPase activator activity
ACT74_RS07150	COG0590	tRNA wobble adenosine to inosine editing
ACT74_RS07170	COG0730	response to heat
ACT74_RS07180	COG1869	D-ribose catabolic process
ACT74_RS07190	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACT74_RS07195	COG1879	ABC-type sugar transport system periplasmic component
ACT74_RS07200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACT74_RS07205	COG1278	Cold shock
ACT74_RS07240	COG0165	Argininosuccinate lyase
ACT74_RS07245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACT74_RS07250	COG0753	catalase activity
ACT74_RS07255	COG0587	DNA-directed DNA polymerase activity
ACT74_RS07260	COG1022	Amp-dependent synthetase and ligase
ACT74_RS07270	COG1328	CTP reductase activity
ACT74_RS07270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACT74_RS07275	COG0602	queuosine metabolic process
ACT74_RS07280	COG0084	hydrolase, TatD family'
ACT74_RS07290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACT74_RS07315	COG1686	Belongs to the peptidase S11 family
ACT74_RS07320	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACT74_RS07320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACT74_RS07325	COG0772	Belongs to the SEDS family
ACT74_RS07330	COG0768	penicillin binding
ACT74_RS07340	COG0799	negative regulation of ribosome biogenesis
ACT74_RS07345	COG0513	Belongs to the DEAD box helicase family
ACT74_RS07350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACT74_RS07355	COG2814	Major facilitator Superfamily
ACT74_RS07365	COG1028	Short-chain dehydrogenase reductase Sdr
ACT74_RS07370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACT74_RS07380	COG0416	fatty acid biosynthetic process
ACT74_RS07390	COG1399	metal-binding, possibly nucleic acid-binding protein
ACT74_RS07400	COG0500	methyltransferase
ACT74_RS07405	COG2830	Protein of unknown function (DUF452)
ACT74_RS07415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACT74_RS07420	COG0688	phosphatidylethanolamine metabolic process
ACT74_RS07425	COG0545	Peptidyl-prolyl cis-trans isomerase
ACT74_RS07445	COG2966	Psort location CytoplasmicMembrane, score
ACT74_RS07450	COG3610	response to peptide
ACT74_RS07455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACT74_RS07460	COG1253	flavin adenine dinucleotide binding
ACT74_RS07470	COG0084	hydrolase, TatD family'
ACT74_RS07475	COG0470	DNA polymerase III
ACT74_RS07480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACT74_RS07485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACT74_RS07490	COG0347	Belongs to the P(II) protein family
ACT74_RS07495	COG1349	DNA-binding transcription factor activity
ACT74_RS07500	COG2084	Dehydrogenase
ACT74_RS07505	COG3395	kinase activity
ACT74_RS07510	COG0235	Class ii aldolase
ACT74_RS07520	COG2610	gluconate transmembrane transporter activity
ACT74_RS07535	COG0561	phosphatase activity
ACT74_RS07560	COG3085	chromosome segregation
ACT74_RS07565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACT74_RS07570	COG3084	Protein conserved in bacteria
ACT74_RS07575	COG0746	molybdenum cofactor guanylyltransferase activity
ACT74_RS07585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT74_RS07585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT74_RS07590	COG1105	Belongs to the carbohydrate kinase PfkB family
ACT74_RS07595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACT74_RS07595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACT74_RS07595	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ACT74_RS07625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACT74_RS07645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACT74_RS07670	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACT74_RS07675	COG0255	Belongs to the universal ribosomal protein uL29 family
ACT74_RS07680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACT74_RS07685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACT74_RS07690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACT74_RS07695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACT74_RS07700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACT74_RS07705	COG0089	rRNA binding
ACT74_RS07710	COG0088	Forms part of the polypeptide exit tunnel
ACT74_RS07715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACT74_RS07720	COG0051	transcription antitermination factor activity, RNA binding
ACT74_RS07725	COG0583	DNA-binding transcription factor activity
ACT74_RS07735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACT74_RS07740	COG2031	fatty acid transporter
ACT74_RS07755	COG1288	antiporter activity
ACT74_RS07760	COG0549	Belongs to the carbamate kinase family
ACT74_RS07765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACT74_RS07770	COG0038	chloride channel
ACT74_RS07775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACT74_RS07785	COG1522	sequence-specific DNA binding
ACT74_RS07790	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ACT74_RS07800	COG1393	Belongs to the ArsC family
ACT74_RS07810	COG3036	rescue of stalled ribosome
ACT74_RS07815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACT74_RS07820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACT74_RS07825	COG2841	Protein conserved in bacteria
ACT74_RS07840	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ACT74_RS07850	COG0569	domain protein
ACT74_RS07855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACT74_RS07855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACT74_RS07895	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ACT74_RS07900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACT74_RS07910	COG1739	Uncharacterized protein family UPF0029
ACT74_RS07920	COG3172	ATPase kinase involved in NAD metabolism
ACT74_RS07925	COG2129	metallophosphoesterase
ACT74_RS07930	COG0814	amino acid
ACT74_RS07950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACT74_RS07965	COG0201	protein transport
ACT74_RS07985	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACT74_RS07995	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACT74_RS08005	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACT74_RS08030	COG1114	Component of the transport system for branched-chain amino acids
ACT74_RS08040	COG1040	competence protein
ACT74_RS08045	COG0561	phosphatase activity
ACT74_RS08050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACT74_RS08055	COG1596	polysaccharide export
ACT74_RS08055	COG1555	photosystem II stabilization
ACT74_RS08075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACT74_RS08080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACT74_RS08090	COG1011	Hydrolase
ACT74_RS08115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACT74_RS08170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACT74_RS08180	COG1028	Short-chain dehydrogenase reductase Sdr
ACT74_RS08185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACT74_RS08200	COG4545	Glutaredoxin-related protein
ACT74_RS08205	COG1794	racemase activity, acting on amino acids and derivatives
ACT74_RS08215	COG0363	glucosamine-6-phosphate deaminase activity
ACT74_RS08220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACT74_RS08225	COG1218	3'(2'),5'-bisphosphate nucleotidase
ACT74_RS08235	COG1297	OPT oligopeptide transporter protein
ACT74_RS08240	COG3059	membrane
ACT74_RS08245	COG4977	sequence-specific DNA binding
ACT74_RS08245	COG1917	Cupin 2, conserved barrel domain protein
ACT74_RS08250	COG0494	nUDIX hydrolase
ACT74_RS08255	COG1011	Hydrolase
ACT74_RS08260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ACT74_RS08265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ACT74_RS08270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACT74_RS08275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACT74_RS08280	COG0805	protein transport
ACT74_RS08305	COG4545	Glutaredoxin-related protein
ACT74_RS08315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACT74_RS08315	COG2221	Nitrite and sulphite reductase 4Fe-4S
ACT74_RS08320	COG3381	protein complex oligomerization
ACT74_RS08325	COG3302	dmso reductase anchor subunit
ACT74_RS08330	COG0437	4 iron, 4 sulfur cluster binding
ACT74_RS08335	COG0243	molybdopterin cofactor binding
ACT74_RS08380	COG0848	biopolymer transport protein
ACT74_RS08385	COG0811	peptide transport
ACT74_RS08390	COG4536	flavin adenine dinucleotide binding
ACT74_RS08395	COG4137	Cytochrome C assembly protein
ACT74_RS08400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACT74_RS08405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACT74_RS08410	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACT74_RS08420	COG4221	oxidoreductase activity
ACT74_RS08425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACT74_RS08445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACT74_RS08450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACT74_RS08455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACT74_RS08460	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
ACT74_RS08465	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
ACT74_RS08480	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ACT74_RS08485	COG1466	dna polymerase III delta subunit
ACT74_RS08490	COG0494	nUDIX hydrolase
ACT74_RS08505	COG4701	Protein of unknown function (DUF721)
ACT74_RS08510	COG0789	Transcriptional regulator
ACT74_RS08515	COG2801	Transposase and inactivated derivatives
ACT74_RS08525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACT74_RS08605	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ACT74_RS08620	COG4796	Type ii and iii secretion system protein
ACT74_RS08640	COG4972	Pilus assembly protein
ACT74_RS08645	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACT74_RS08650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ACT74_RS08655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACT74_RS08670	COG1309	transcriptional regulator
ACT74_RS08680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACT74_RS08715	COG3306	glycosyltransferase involved in LPS biosynthesis
ACT74_RS08725	COG3306	glycosyltransferase involved in LPS biosynthesis
ACT74_RS08740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACT74_RS08745	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACT74_RS08750	COG1309	transcriptional regulator
ACT74_RS08755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACT74_RS08760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACT74_RS08775	COG0762	integral membrane protein
ACT74_RS08785	COG0778	Nitroreductase
ACT74_RS08790	COG1368	sulfuric ester hydrolase activity
ACT74_RS08795	COG1496	oxidoreductase activity
ACT74_RS08810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACT74_RS08830	COG0006	proline dipeptidase activity
ACT74_RS08855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ACT74_RS08860	COG1792	Involved in formation and maintenance of cell shape
ACT74_RS08865	COG1077	Cell shape determining protein MreB Mrl
ACT74_RS08870	COG0557	exoribonuclease II activity
ACT74_RS08880	COG2271	Major facilitator Superfamily
ACT74_RS08885	COG0584	glycerophosphoryl diester phosphodiesterase
ACT74_RS08890	COG0758	DNA mediated transformation
ACT74_RS08925	COG1132	(ABC) transporter
ACT74_RS08930	COG4977	sequence-specific DNA binding
ACT74_RS08930	COG1917	Cupin 2, conserved barrel domain protein
ACT74_RS08935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACT74_RS08940	COG0859	PFAM glycosyl transferase family 9
ACT74_RS08955	COG1519	Transferase
ACT74_RS08960	COG0463	Glycosyl transferase, family 2
ACT74_RS08965	COG1388	LysM domain
ACT74_RS08965	COG4942	peptidase
ACT74_RS08975	COG1238	metal cluster binding
ACT74_RS09005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACT74_RS09015	COG2884	Cell division ATP-binding protein ftsE
ACT74_RS09020	COG2177	Part of the ABC transporter FtsEX involved in
ACT74_RS09025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACT74_RS09030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACT74_RS09040	COG0561	phosphatase activity
ACT74_RS09045	COG2267	carboxylic ester hydrolase activity
ACT74_RS09050	COG3307	-O-antigen
ACT74_RS09055	COG0191	fructose-bisphosphate aldolase activity
ACT74_RS09065	COG3719	Belongs to the RNase T2 family
ACT74_RS09070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACT74_RS09075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACT74_RS09080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACT74_RS09085	COG2801	Transposase and inactivated derivatives
ACT74_RS09095	COG1070	Carbohydrate kinase
ACT74_RS09100	COG2115	Belongs to the xylose isomerase family
ACT74_RS09105	COG4213	ABC transporter substrate-binding protein
ACT74_RS09110	COG1129	ABC transporter
ACT74_RS09115	COG4214	carbohydrate transport
ACT74_RS09120	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ACT74_RS09125	COG1757	Na H antiporter
ACT74_RS09130	COG1609	Transcriptional regulator
ACT74_RS09130	COG2207	Transcriptional regulator
ACT74_RS09135	COG2814	Major facilitator Superfamily
ACT74_RS09140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACT74_RS09140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT74_RS09145	COG3715	PTS system
ACT74_RS09150	COG3716	PTS system mannose fructose sorbose family IID component
ACT74_RS09160	COG0732	type I restriction modification DNA specificity domain
ACT74_RS09180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACT74_RS09195	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACT74_RS09205	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACT74_RS09225	COG3312	ion transport
ACT74_RS09235	COG1733	regulation of RNA biosynthetic process
ACT74_RS09240	COG0702	epimerase
ACT74_RS09250	COG0716	FMN binding
ACT74_RS09260	COG1494	fructose-1,6-bisphosphatase
ACT74_RS09265	COG1045	serine acetyltransferase
ACT74_RS09275	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ACT74_RS09280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACT74_RS09285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ACT74_RS09290	COG4988	ABC transporter
ACT74_RS09295	COG1132	(ABC) transporter
ACT74_RS09300	COG1309	transcriptional regulator
ACT74_RS09305	COG0583	DNA-binding transcription factor activity
ACT74_RS09310	COG0678	peroxiredoxin activity
ACT74_RS09310	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACT74_RS09315	COG2900	Belongs to the SlyX family
ACT74_RS09320	COG0545	Peptidyl-prolyl cis-trans isomerase
ACT74_RS09325	COG2964	Protein conserved in bacteria
ACT74_RS09330	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ACT74_RS09340	COG2168	tRNA wobble position uridine thiolation
ACT74_RS09345	COG1126	abc transporter atp-binding protein
ACT74_RS09350	COG0765	amino acid transport
ACT74_RS09355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACT74_RS09360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACT74_RS09385	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ACT74_RS09395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACT74_RS09405	COG1349	DNA-binding transcription factor activity
ACT74_RS09435	COG2095	MarC family integral membrane protein
ACT74_RS09440	COG0488	(ABC) transporter
ACT74_RS09535	COG0488	(ABC) transporter
ACT74_RS09540	COG0488	(ABC) transporter
ACT74_RS09545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACT74_RS09550	COG2137	regulation of response to DNA damage stimulus
ACT74_RS09555	COG0251	oxidation-reduction process
ACT74_RS09565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACT74_RS09590	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACT74_RS09595	COG4589	Belongs to the CDS family
ACT74_RS09605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACT74_RS09610	COG0490	domain, Protein
ACT74_RS09610	COG0471	metal ion transport
ACT74_RS09620	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACT74_RS09640	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ACT74_RS09655	COG0575	Belongs to the CDS family
ACT74_RS09670	COG0233	cytoplasmic translational termination
ACT74_RS09685	COG4178	(ABC) transporter
ACT74_RS09695	COG1349	DNA-binding transcription factor activity
ACT74_RS09700	COG0705	Rhomboid family
ACT74_RS09725	COG0551	DNA topoisomerase type I activity
ACT74_RS09740	COG2962	Rard protein
ACT74_RS09745	COG0583	DNA-binding transcription factor activity
ACT74_RS09755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACT74_RS09770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACT74_RS09775	COG3070	regulator of competence-specific genes
ACT74_RS09780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACT74_RS09790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACT74_RS09795	COG3850	Histidine kinase
ACT74_RS09800	COG3062	negative regulation of establishment of protein localization
ACT74_RS09805	COG0243	molybdopterin cofactor binding
ACT74_RS09810	COG0437	4 iron, 4 sulfur cluster binding
ACT74_RS09815	COG0348	domain, Protein
ACT74_RS09820	COG3043	anaerobic respiration
ACT74_RS09825	COG3005	denitrification pathway
ACT74_RS09830	COG0754	glutathionylspermidine amidase activity
ACT74_RS09835	COG0859	PFAM glycosyl transferase family 9
ACT74_RS09845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACT74_RS09855	COG0737	Belongs to the 5'-nucleotidase family
ACT74_RS09870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACT74_RS09870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACT74_RS09880	COG5645	(Lipo)protein
ACT74_RS09885	COG0210	DNA helicase
ACT74_RS09910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACT74_RS09915	COG0110	maltose O-acetyltransferase activity
ACT74_RS09920	COG1238	metal cluster binding
ACT74_RS09935	COG3201	nicotinamide mononucleotide transporter
ACT74_RS09945	COG0513	Belongs to the DEAD box helicase family
ACT74_RS09975	COG2271	Major facilitator Superfamily
ACT74_RS09985	COG1215	transferase activity, transferring glycosyl groups
ACT74_RS09990	COG0726	polysaccharide deacetylase
ACT74_RS09990	COG1649	PFAM Uncharacterised BCR, COG1649
ACT74_RS10005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACT74_RS10010	COG0561	phosphatase activity
ACT74_RS10015	COG3716	PTS system mannose fructose sorbose family IID component
ACT74_RS10020	COG3715	PTS system
ACT74_RS10025	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT74_RS10025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACT74_RS10030	COG0742	ribosomal rna small subunit methyltransferase
ACT74_RS10035	COG0552	protein localization to endoplasmic reticulum
ACT74_RS10045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACT74_RS10050	COG4783	chaperone-mediated protein folding
ACT74_RS10060	COG0814	amino acid
ACT74_RS10085	COG0747	negative chemotaxis
ACT74_RS10090	COG2853	Lipoprotein
ACT74_RS10105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACT74_RS10110	COG4942	peptidase
ACT74_RS10115	COG2861	carbohydrate metabolic process
ACT74_RS10120	COG0606	chelatase, subunit chli
ACT74_RS10200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACT74_RS10220	COG0606	chelatase, subunit chli
ACT74_RS10230	COG2990	Protein conserved in bacteria
ACT74_RS10235	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACT74_RS10255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system