locus-tag	class	description
I6H44_RS00005	COG0443	Heat shock 70 kDa protein
I6H44_RS00025	COG0484	heat shock protein binding
I6H44_RS00035	COG0626	cystathionine gamma-synthase activity
I6H44_RS00040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H44_RS00060	COG1858	cytochrome C peroxidase
I6H44_RS00065	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6H44_RS00070	COG0318	PFAM AMP-dependent synthetase and ligase
I6H44_RS00075	COG3065	identical protein binding
I6H44_RS00080	COG1214	PFAM Peptidase M22, glycoprotease
I6H44_RS00085	COG1199	ATP-dependent helicase activity
I6H44_RS00090	COG0676	glucose-6-phosphate 1-epimerase activity
I6H44_RS00100	COG0753	catalase activity
I6H44_RS00110	COG3384	dioxygenase
I6H44_RS00115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6H44_RS00125	COG3118	belongs to the thioredoxin family
I6H44_RS00130	COG0492	ferredoxin-NADP+ reductase activity
I6H44_RS00135	COG4988	ABC transporter
I6H44_RS00140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6H44_RS00150	COG1946	Acyl-CoA thioesterase
I6H44_RS00155	COG2833	Protein of unknown function (DUF455)
I6H44_RS00165	COG0515	serine threonine protein kinase
I6H44_RS00180	COG1940	carbohydrate kinase activity
I6H44_RS00185	COG0671	phosphoesterase, PA-phosphatase related
I6H44_RS00195	COG4166	transmembrane transport
I6H44_RS00205	COG0339	signal peptide processing
I6H44_RS00210	COG2190	(PTS) system
I6H44_RS00215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H44_RS00220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H44_RS00245	COG0802	atpase or kinase
I6H44_RS00250	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H44_RS00250	COG1388	LysM domain
I6H44_RS00255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H44_RS00265	COG1923	regulation of RNA biosynthetic process
I6H44_RS00270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H44_RS00275	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6H44_RS00285	COG3106	COG3106 Predicted ATPase
I6H44_RS00300	COG4166	transmembrane transport
I6H44_RS00305	COG4168	peptide transport system, permease
I6H44_RS00310	COG4171	peptide transport system, permease
I6H44_RS00315	COG4172	Belongs to the ABC transporter superfamily
I6H44_RS00320	COG4172	Belongs to the ABC transporter superfamily
I6H44_RS00345	COG1940	carbohydrate kinase activity
I6H44_RS00345	COG1846	Transcriptional regulator
I6H44_RS00360	COG2226	methyltransferase
I6H44_RS00365	COG2190	(PTS) system
I6H44_RS00365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H44_RS00365	COG1263	PTS System
I6H44_RS00370	COG3422	double-strand break repair
I6H44_RS00380	COG1944	ATP diphosphatase activity
I6H44_RS00385	COG3105	Protein conserved in bacteria
I6H44_RS00390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H44_RS00405	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6H44_RS00410	COG3683	transport system, periplasmic component
I6H44_RS00415	COG0488	(ABC) transporter
I6H44_RS00425	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6H44_RS00430	COG1858	cytochrome C peroxidase
I6H44_RS00435	COG0187	DNA topoisomerase II activity
I6H44_RS00440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H44_RS00445	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6H44_RS00460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H44_RS00470	COG1560	Kdo2-lipid A biosynthetic process
I6H44_RS00475	COG0730	response to heat
I6H44_RS00480	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6H44_RS00490	COG3264	Mechanosensitive ion channel
I6H44_RS00490	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6H44_RS00495	COG0318	PFAM AMP-dependent synthetase and ligase
I6H44_RS00500	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6H44_RS00505	COG0596	Alpha beta hydrolase
I6H44_RS00515	COG0716	FMN binding
I6H44_RS00520	COG0735	belongs to the Fur family
I6H44_RS00525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H44_RS00530	COG3094	Invasion gene expression up-regulator, SirB
I6H44_RS00535	COG0023	Translation Initiation Factor
I6H44_RS00545	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6H44_RS00550	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6H44_RS00560	COG0539	negative regulation of cytoplasmic translation
I6H44_RS00565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H44_RS00570	COG2990	Protein conserved in bacteria
I6H44_RS00575	COG1687	branched-chain amino acid
I6H44_RS00580	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6H44_RS00585	COG0583	DNA-binding transcription factor activity
I6H44_RS00595	COG2188	Transcriptional regulator
I6H44_RS00600	COG0058	SHG alpha-glucan phosphorylase activity
I6H44_RS00610	COG2190	(PTS) system
I6H44_RS00610	COG1263	PTS System
I6H44_RS00610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H44_RS00620	COG2920	part of a sulfur-relay system
I6H44_RS00630	COG1121	(ABC) transporter
I6H44_RS00635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H44_RS00640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H44_RS00650	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6H44_RS00660	COG3304	Inner membrane component domain
I6H44_RS00665	COG1289	transmembrane transporter activity
I6H44_RS00680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6H44_RS00690	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H44_RS00695	COG0567	Dehydrogenase, E1 component
I6H44_RS00700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H44_RS00705	COG3108	Peptidase M15
I6H44_RS00710	COG2989	Protein conserved in bacteria
I6H44_RS00715	COG0793	Belongs to the peptidase S41A family
I6H44_RS00720	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6H44_RS00725	COG2995	paraquat-inducible protein a
I6H44_RS00730	COG3008	intermembrane lipid transfer
I6H44_RS00745	COG3842	ATPase activity
I6H44_RS00750	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6H44_RS00755	COG1177	transmembrane transport
I6H44_RS00760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6H44_RS00775	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6H44_RS00780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H44_RS00795	COG1522	sequence-specific DNA binding
I6H44_RS00805	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6H44_RS00810	COG3025	triphosphatase activity
I6H44_RS00815	COG1392	Phosphate transport regulator
I6H44_RS00820	COG0306	phosphate transporter
I6H44_RS00825	COG4991	sh3 domain protein
I6H44_RS00835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6H44_RS00840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6H44_RS00845	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H44_RS00855	COG4953	penicillin-binding protein 1C
I6H44_RS00860	COG2855	membrane
I6H44_RS00880	COG0157	Belongs to the NadC ModD family
I6H44_RS00885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H44_RS00890	COG1530	ribonuclease E activity
I6H44_RS00895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H44_RS00925	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6H44_RS00930	COG1959	2 iron, 2 sulfur cluster binding
I6H44_RS00940	COG0822	iron-sulfur transferase activity
I6H44_RS00965	COG0443	Heat shock 70 kDa protein
I6H44_RS00970	COG0633	Ferredoxin
I6H44_RS00975	COG2975	iron-sulfur cluster assembly
I6H44_RS00980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H44_RS00980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H44_RS00985	COG0489	protein tyrosine kinase activity
I6H44_RS01000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H44_RS01005	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6H44_RS01010	COG4535	Mg2 and Co2 transporter CorC
I6H44_RS01015	COG2017	converts alpha-aldose to the beta-anomer
I6H44_RS01020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H44_RS01025	COG1085	galactose-1-phosphate uridylyltransferase
I6H44_RS01030	COG1609	Transcriptional regulator
I6H44_RS01035	COG1879	ABC-type sugar transport system periplasmic component
I6H44_RS01040	COG1129	ABC transporter
I6H44_RS01045	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6H44_RS01050	COG0784	Response regulator, receiver
I6H44_RS01050	COG2198	Histidine kinase
I6H44_RS01050	COG5002	protein histidine kinase activity
I6H44_RS01055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H44_RS01060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H44_RS01060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6H44_RS01070	COG1629	transport
I6H44_RS01070	COG4771	TonB-dependent receptor
I6H44_RS01075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H44_RS01085	COG0497	DNA recombination
I6H44_RS01100	COG1607	acyl-coa hydrolase
I6H44_RS01105	COG2350	Protein conserved in bacteria
I6H44_RS01110	COG0741	lytic transglycosylase activity
I6H44_RS01120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H44_RS01145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H44_RS01150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H44_RS01160	COG1408	metallophosphoesterase
I6H44_RS01165	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6H44_RS01170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H44_RS01175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H44_RS01180	COG1120	ATPase activity
I6H44_RS01190	COG1053	succinate dehydrogenase
I6H44_RS01195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6H44_RS01205	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6H44_RS01230	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6H44_RS01235	COG0494	nUDIX hydrolase
I6H44_RS01240	COG1876	peptidase activity
I6H44_RS01265	COG1393	Belongs to the ArsC family
I6H44_RS01270	COG0326	Molecular chaperone. Has ATPase activity
I6H44_RS01275	COG0077	Prephenate dehydratase
I6H44_RS01275	COG1605	Chorismate mutase
I6H44_RS01290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H44_RS01295	COG0849	cell division
I6H44_RS01300	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6H44_RS01325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H44_RS01335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H44_RS01345	COG0768	penicillin binding
I6H44_RS01350	COG3116	cell division
I6H44_RS01365	COG1966	Carbon starvation protein
I6H44_RS01375	COG4160	amino acid transport
I6H44_RS01380	COG4215	(ABC) transporter
I6H44_RS01385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H44_RS01390	COG1126	abc transporter atp-binding protein
I6H44_RS01420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H44_RS01435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H44_RS01440	COG1758	RNA polymerase activity
I6H44_RS01450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H44_RS01460	COG2914	Belongs to the UPF0125 (RnfH) family
I6H44_RS01465	COG2850	peptidyl-arginine hydroxylation
I6H44_RS01475	COG1660	Displays ATPase and GTPase activities
I6H44_RS01480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H44_RS01485	COG1137	ATPase activity
I6H44_RS01490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6H44_RS01495	COG3117	lipopolysaccharide transmembrane transporter activity
I6H44_RS01500	COG1127	ABC transporter
I6H44_RS01505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6H44_RS01510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6H44_RS01515	COG2854	intermembrane phospholipid transfer
I6H44_RS01520	COG3113	response to antibiotic
I6H44_RS01525	COG5007	Belongs to the BolA IbaG family
I6H44_RS01535	COG3691	Protein conserved in bacteria
I6H44_RS01540	COG2067	long-chain fatty acid transport protein
I6H44_RS01545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H44_RS01555	COG0861	Integral membrane protein TerC family
I6H44_RS01560	COG0174	glutamine synthetase
I6H44_RS01565	COG1217	gtp-binding protein TYPA
I6H44_RS01570	COG3266	domain, Protein
I6H44_RS01570	COG3468	outer membrane autotransporter barrel domain protein
I6H44_RS01585	COG1132	(ABC) transporter
I6H44_RS01585	COG2375	cellular response to nickel ion
I6H44_RS01590	COG1629	transport
I6H44_RS01590	COG4774	siderophore transport
I6H44_RS01600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6H44_RS01615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H44_RS01620	COG0460	homoserine dehydrogenase
I6H44_RS01620	COG0527	aspartate kinase activity
I6H44_RS01630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6H44_RS01635	COG2091	lysine biosynthetic process via aminoadipic acid
I6H44_RS01640	COG0330	HflC and HflK could
I6H44_RS01645	COG0330	HflC and HflK could
I6H44_RS01655	COG4974	Belongs to the 'phage' integrase family
I6H44_RS01660	COG2814	Major facilitator Superfamily
I6H44_RS01665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H44_RS01695	COG1476	TRANSCRIPTIONal
I6H44_RS01700	COG0582	viral genome integration into host DNA
I6H44_RS01715	COG2081	HI0933 family
I6H44_RS01720	COG4235	cytochrome complex assembly
I6H44_RS01720	COG3088	subunit of a heme lyase
I6H44_RS01725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H44_RS01730	COG1138	Cytochrome C-type biogenesis protein
I6H44_RS01735	COG3301	Polysulphide reductase, NrfD
I6H44_RS01740	COG0437	4 iron, 4 sulfur cluster binding
I6H44_RS01745	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6H44_RS01770	COG1138	Cytochrome C-type biogenesis protein
I6H44_RS01780	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6H44_RS01785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6H44_RS01790	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6H44_RS01795	COG4133	protoheme IX ABC transporter activity
I6H44_RS01800	COG2814	Major facilitator Superfamily
I6H44_RS01805	COG1187	pseudouridine synthase activity
I6H44_RS01810	COG0280	phosphate acetyltransferase
I6H44_RS01810	COG0281	malic enzyme
I6H44_RS01825	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6H44_RS01830	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6H44_RS01840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6H44_RS01855	COG0436	Aminotransferase
I6H44_RS01865	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6H44_RS01870	COG2267	carboxylic ester hydrolase activity
I6H44_RS01910	COG4145	pantothenate transmembrane transporter activity
I6H44_RS01915	COG3924	membrane
I6H44_RS01920	COG0439	Biotin carboxylase
I6H44_RS01925	COG0511	ligase activity, forming carbon-carbon bonds
I6H44_RS01940	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6H44_RS01945	COG0149	triose-phosphate isomerase activity
I6H44_RS01950	COG0456	acetyltransferase
I6H44_RS01955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H44_RS01965	COG3078	GTPase activator activity
I6H44_RS01970	COG0590	tRNA wobble adenosine to inosine editing
I6H44_RS01975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6H44_RS01985	COG0730	response to heat
I6H44_RS02000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H44_RS02035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H44_RS02040	COG0121	glutamine amidotransferase
I6H44_RS02045	COG0587	DNA-directed DNA polymerase activity
I6H44_RS02050	COG1022	Amp-dependent synthetase and ligase
I6H44_RS02055	COG1328	CTP reductase activity
I6H44_RS02055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H44_RS02060	COG0602	queuosine metabolic process
I6H44_RS02065	COG0084	hydrolase, TatD family'
I6H44_RS02070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6H44_RS02095	COG1686	Belongs to the peptidase S11 family
I6H44_RS02105	COG0772	Belongs to the SEDS family
I6H44_RS02110	COG0768	penicillin binding
I6H44_RS02120	COG0799	negative regulation of ribosome biogenesis
I6H44_RS02125	COG0513	Belongs to the DEAD box helicase family
I6H44_RS02130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6H44_RS02135	COG2814	Major facilitator Superfamily
I6H44_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
I6H44_RS02150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6H44_RS02170	COG1399	metal-binding, possibly nucleic acid-binding protein
I6H44_RS02180	COG2226	methyltransferase
I6H44_RS02185	COG2830	Protein of unknown function (DUF452)
I6H44_RS02195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6H44_RS02200	COG0688	phosphatidylethanolamine metabolic process
I6H44_RS02205	COG0545	Peptidyl-prolyl cis-trans isomerase
I6H44_RS02215	COG0628	permease
I6H44_RS02220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H44_RS02225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H44_RS02230	COG0470	DNA polymerase III
I6H44_RS02235	COG0084	hydrolase, TatD family'
I6H44_RS02245	COG1253	flavin adenine dinucleotide binding
I6H44_RS02250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H44_RS02255	COG3610	response to peptide
I6H44_RS02260	COG2966	Psort location CytoplasmicMembrane, score
I6H44_RS02265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6H44_RS02270	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H44_RS02275	COG4589	Belongs to the CDS family
I6H44_RS02285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H44_RS02290	COG0471	metal ion transport
I6H44_RS02290	COG0490	domain, Protein
I6H44_RS02310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6H44_RS02335	COG0575	Belongs to the CDS family
I6H44_RS02350	COG0233	cytoplasmic translational termination
I6H44_RS02365	COG4178	(ABC) transporter
I6H44_RS02380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6H44_RS02390	COG2226	methyltransferase
I6H44_RS02395	COG0814	amino acid
I6H44_RS02410	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6H44_RS02420	COG0811	peptide transport
I6H44_RS02425	COG4536	flavin adenine dinucleotide binding
I6H44_RS02430	COG4137	Cytochrome C assembly protein
I6H44_RS02435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H44_RS02470	COG0758	DNA mediated transformation
I6H44_RS02475	COG1595	DNA-templated transcription, initiation
I6H44_RS02485	COG1368	sulfuric ester hydrolase activity
I6H44_RS02490	COG0778	Nitroreductase
I6H44_RS02500	COG0762	integral membrane protein
I6H44_RS02510	COG0500	methyltransferase
I6H44_RS02515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H44_RS02520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H44_RS02525	COG1309	transcriptional regulator
I6H44_RS02530	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6H44_RS02535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H44_RS02545	COG0438	transferase activity, transferring glycosyl groups
I6H44_RS02555	COG3306	glycosyltransferase involved in LPS biosynthesis
I6H44_RS02590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H44_RS02600	COG1309	transcriptional regulator
I6H44_RS02615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H44_RS02620	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6H44_RS02625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6H44_RS02630	COG4972	Pilus assembly protein
I6H44_RS02650	COG4796	Type ii and iii secretion system protein
I6H44_RS02660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H44_RS02665	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6H44_RS02670	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6H44_RS02675	COG0778	Nitroreductase
I6H44_RS02695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H44_RS02700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H44_RS02705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H44_RS02710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H44_RS02715	COG3719	Belongs to the RNase T2 family
I6H44_RS02725	COG0191	fructose-bisphosphate aldolase activity
I6H44_RS02730	COG2267	carboxylic ester hydrolase activity
I6H44_RS02735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6H44_RS02740	COG0561	phosphatase activity
I6H44_RS02750	COG0028	Belongs to the TPP enzyme family
I6H44_RS02770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H44_RS02780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6H44_RS02795	COG1131	(ABC) transporter
I6H44_RS02820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H44_RS02825	COG1028	Short-chain dehydrogenase reductase Sdr
I6H44_RS02835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H44_RS02910	COG1011	Hydrolase
I6H44_RS02915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6H44_RS02920	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6H44_RS02925	COG1132	(ABC) transporter
I6H44_RS02930	COG1917	Cupin 2, conserved barrel domain protein
I6H44_RS02930	COG4977	sequence-specific DNA binding
I6H44_RS02935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6H44_RS02940	COG0859	PFAM glycosyl transferase family 9
I6H44_RS02945	COG3642	lipopolysaccharide core region biosynthetic process
I6H44_RS02955	COG1519	Transferase
I6H44_RS02960	COG0463	Glycosyl transferase, family 2
I6H44_RS02975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H44_RS02995	COG0201	protein transport
I6H44_RS03015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H44_RS03025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H44_RS03035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H44_RS03050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H44_RS03055	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H44_RS03060	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H44_RS03065	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H44_RS03070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H44_RS03075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H44_RS03080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H44_RS03085	COG0089	rRNA binding
I6H44_RS03090	COG0088	Forms part of the polypeptide exit tunnel
I6H44_RS03095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H44_RS03100	COG0051	transcription antitermination factor activity, RNA binding
I6H44_RS03105	COG1522	sequence-specific DNA binding
I6H44_RS03110	COG1288	antiporter activity
I6H44_RS03115	COG0549	Belongs to the carbamate kinase family
I6H44_RS03120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H44_RS03125	COG0038	chloride channel
I6H44_RS03140	COG1522	sequence-specific DNA binding
I6H44_RS03145	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6H44_RS03170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6H44_RS03175	COG2364	Membrane
I6H44_RS03180	COG0859	PFAM glycosyl transferase family 9
I6H44_RS03185	COG1027	Aspartate ammonia-lyase
I6H44_RS03190	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6H44_RS03195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H44_RS03200	COG0459	protein refolding
I6H44_RS03220	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6H44_RS03265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6H44_RS03270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H44_RS03285	COG1881	PFAM PEBP family protein
I6H44_RS03290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H44_RS03295	COG2990	Protein conserved in bacteria
I6H44_RS03305	COG0606	chelatase, subunit chli
I6H44_RS03375	COG0606	chelatase, subunit chli
I6H44_RS03380	COG2861	carbohydrate metabolic process
I6H44_RS03385	COG4942	peptidase
I6H44_RS03390	COG2831	hemolysin activation secretion protein
I6H44_RS03395	COG3210	domain, Protein
I6H44_RS03395	COG3210	domain, Protein
I6H44_RS03425	COG2354	Protein conserved in bacteria
I6H44_RS03430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H44_RS03445	COG2853	Lipoprotein
I6H44_RS03465	COG4771	TonB-dependent receptor
I6H44_RS03465	COG1629	transport
I6H44_RS03495	COG0363	glucosamine-6-phosphate deaminase activity
I6H44_RS03500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6H44_RS03505	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6H44_RS03515	COG1297	OPT oligopeptide transporter protein
I6H44_RS03520	COG3059	membrane
I6H44_RS03525	COG2207	Transcriptional regulator
I6H44_RS03530	COG0494	nUDIX hydrolase
I6H44_RS03535	COG1011	Hydrolase
I6H44_RS03540	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H44_RS03545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6H44_RS03550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H44_RS03555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6H44_RS03560	COG0805	protein transport
I6H44_RS03570	COG0751	glycine-tRNA ligase activity
I6H44_RS03580	COG2852	Protein conserved in bacteria
I6H44_RS03595	COG4545	Glutaredoxin-related protein
I6H44_RS03605	COG0752	glycyl-tRNA synthetase alpha subunit
I6H44_RS03610	COG1733	regulation of RNA biosynthetic process
I6H44_RS03615	COG0702	epimerase
I6H44_RS03625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H44_RS03625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H44_RS03635	COG5645	(Lipo)protein
I6H44_RS03640	COG0210	DNA helicase
I6H44_RS03665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H44_RS03670	COG1238	metal cluster binding
I6H44_RS03695	COG3201	nicotinamide mononucleotide transporter
I6H44_RS03705	COG0513	Belongs to the DEAD box helicase family
I6H44_RS03735	COG3070	regulator of competence-specific genes
I6H44_RS03745	COG0582	viral genome integration into host DNA
I6H44_RS03800	COG3676	manually curated
I6H44_RS03805	COG2814	Major facilitator Superfamily
I6H44_RS03810	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6H44_RS03815	COG3086	response to oxidative stress
I6H44_RS03820	COG3026	antisigma factor binding
I6H44_RS03825	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6H44_RS03830	COG1595	DNA-templated transcription, initiation
I6H44_RS03845	COG0442	prolyl-tRNA aminoacylation
I6H44_RS03850	COG1921	L-seryl-tRNASec selenium transferase activity
I6H44_RS03855	COG3276	selenocysteine insertion sequence binding
I6H44_RS03865	COG1285	pathogenesis
I6H44_RS03875	COG0733	neurotransmitter:sodium symporter activity
I6H44_RS03900	COG1132	(ABC) transporter
I6H44_RS03905	COG4988	ABC transporter
I6H44_RS03910	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6H44_RS03915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H44_RS03920	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6H44_RS03930	COG1045	serine acetyltransferase
I6H44_RS03935	COG1494	fructose-1,6-bisphosphatase
I6H44_RS03940	COG3074	FtsZ-dependent cytokinesis
I6H44_RS03945	COG0716	FMN binding
I6H44_RS03950	COG0445	tRNA wobble uridine modification
I6H44_RS03960	COG3312	ion transport
I6H44_RS03990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6H44_RS03995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6H44_RS04030	COG4942	peptidase
I6H44_RS04030	COG1388	LysM domain
I6H44_RS04040	COG1238	metal cluster binding
I6H44_RS04070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H44_RS04090	COG0765	amino acid transport
I6H44_RS04095	COG0765	amino acid transport
I6H44_RS04105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H44_RS04155	COG2095	MarC family integral membrane protein
I6H44_RS04160	COG0488	(ABC) transporter
I6H44_RS04165	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H44_RS04175	COG0251	oxidation-reduction process
I6H44_RS04180	COG0019	diaminopimelate decarboxylase activity
I6H44_RS04185	COG1965	Belongs to the frataxin family
I6H44_RS04190	COG0514	ATP-dependent DNA helicase (RecQ)
I6H44_RS04195	COG0187	DNA topoisomerase II activity
I6H44_RS04235	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H44_RS04240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H44_RS04245	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6H44_RS04255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H44_RS04260	COG3850	Histidine kinase
I6H44_RS04265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H44_RS04270	COG3062	negative regulation of establishment of protein localization
I6H44_RS04275	COG0243	molybdopterin cofactor binding
I6H44_RS04280	COG0437	4 iron, 4 sulfur cluster binding
I6H44_RS04285	COG0348	domain, Protein
I6H44_RS04290	COG3043	anaerobic respiration
I6H44_RS04295	COG3005	denitrification pathway
I6H44_RS04300	COG0754	glutathionylspermidine amidase activity
I6H44_RS04305	COG0859	PFAM glycosyl transferase family 9
I6H44_RS04310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H44_RS04315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H44_RS04320	COG1309	transcriptional regulator
I6H44_RS04325	COG0583	DNA-binding transcription factor activity
I6H44_RS04330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H44_RS04330	COG0678	peroxiredoxin activity
I6H44_RS04335	COG2900	Belongs to the SlyX family
I6H44_RS04340	COG0545	Peptidyl-prolyl cis-trans isomerase
I6H44_RS04345	COG2964	Protein conserved in bacteria
I6H44_RS04350	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6H44_RS04360	COG2168	tRNA wobble position uridine thiolation
I6H44_RS04365	COG1126	abc transporter atp-binding protein
I6H44_RS04370	COG0765	amino acid transport
I6H44_RS04375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H44_RS04380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H44_RS04395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6H44_RS04400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H44_RS04410	COG2818	Glycosylase
I6H44_RS04415	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6H44_RS04435	COG1114	Component of the transport system for branched-chain amino acids
I6H44_RS04445	COG0754	glutathionylspermidine amidase activity
I6H44_RS04460	COG3085	chromosome segregation
I6H44_RS04465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H44_RS04470	COG3084	Protein conserved in bacteria
I6H44_RS04475	COG0746	molybdenum cofactor guanylyltransferase activity
I6H44_RS04485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H44_RS04485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H44_RS04490	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H44_RS04495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H44_RS04495	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6H44_RS04495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H44_RS04510	COG1119	ATPase activity
I6H44_RS04520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H44_RS04540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H44_RS04560	COG2816	NAD+ diphosphatase activity
I6H44_RS04565	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6H44_RS04570	COG3068	Protein conserved in bacteria
I6H44_RS04580	COG1349	DNA-binding transcription factor activity
I6H44_RS04585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H44_RS04595	COG0433	COG0433 Predicted ATPase
I6H44_RS04600	COG2258	MOSC domain
I6H44_RS04605	COG3012	SEC-C Motif Domain Protein
I6H44_RS04615	COG1490	D-aminoacyl-tRNA deacylase activity
I6H44_RS04620	COG0786	glutamate:sodium symporter activity
I6H44_RS04625	COG0745	RESPONSE REGULATOR receiver
I6H44_RS04630	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H44_RS04640	COG3082	Protein of unknown function (DUF1414)
I6H44_RS04645	COG3083	sulfuric ester hydrolase activity
I6H44_RS04650	COG0402	S-adenosylhomocysteine deaminase activity
I6H44_RS04655	COG3956	TIGRFAM MazG family protein
I6H44_RS04660	COG0589	response to stress
I6H44_RS04670	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6H44_RS04680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H44_RS04690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H44_RS04710	COG0352	thiamine-phosphate diphosphorylase activity
I6H44_RS04720	COG1114	Component of the transport system for branched-chain amino acids
I6H44_RS04730	COG1040	competence protein
I6H44_RS04735	COG0561	phosphatase activity
I6H44_RS04740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H44_RS04760	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6H44_RS04765	COG1518	maintenance of DNA repeat elements
I6H44_RS04815	COG1337	RAMP superfamily
I6H44_RS04830	COG1555	photosystem II stabilization
I6H44_RS04830	COG1596	polysaccharide export
I6H44_RS04835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H44_RS04845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H44_RS04850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H44_RS04855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6H44_RS04870	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I6H44_RS04875	COG1466	dna polymerase III delta subunit
I6H44_RS04885	COG0494	nUDIX hydrolase
I6H44_RS04900	COG4701	Protein of unknown function (DUF721)
I6H44_RS04905	COG0789	Transcriptional regulator
I6H44_RS04910	COG0814	amino acid
I6H44_RS04915	COG2129	metallophosphoesterase
I6H44_RS04920	COG3172	ATPase kinase involved in NAD metabolism
I6H44_RS04925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H44_RS04935	COG1739	Uncharacterized protein family UPF0029
I6H44_RS04940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H44_RS04945	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6H44_RS04975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H44_RS04980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H44_RS04980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H44_RS04985	COG0569	domain protein
I6H44_RS04995	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6H44_RS05010	COG2841	Protein conserved in bacteria
I6H44_RS05015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H44_RS05020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H44_RS05025	COG3036	rescue of stalled ribosome
I6H44_RS05035	COG1393	Belongs to the ArsC family
I6H44_RS05060	COG0742	ribosomal rna small subunit methyltransferase
I6H44_RS05065	COG0552	protein localization to endoplasmic reticulum
I6H44_RS05070	COG2884	Cell division ATP-binding protein ftsE
I6H44_RS05075	COG2177	Part of the ABC transporter FtsEX involved in
I6H44_RS05080	COG1230	cation diffusion facilitator family transporter
I6H44_RS05085	COG0789	Transcriptional regulator
I6H44_RS05090	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H44_RS05095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H44_RS05100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H44_RS05105	COG1381	Involved in DNA repair and RecF pathway recombination
I6H44_RS05120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6H44_RS05120	COG0475	glutathione-regulated potassium exporter activity
I6H44_RS05130	COG0425	Belongs to the sulfur carrier protein TusA family
I6H44_RS05135	COG2391	methyltransferase activity
I6H44_RS05145	COG0354	folic acid binding
I6H44_RS05150	COG1561	YicC-like family, N-terminal region
I6H44_RS05160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H44_RS05165	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6H44_RS05175	COG3842	ATPase activity
I6H44_RS05180	COG1178	ABC-type Fe3 transport system permease component
I6H44_RS05190	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H44_RS05195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H44_RS05210	COG3171	Protein conserved in bacteria
I6H44_RS05220	COG1194	a g-specific adenine glycosylase
I6H44_RS05225	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6H44_RS05245	COG3056	Lipoprotein
I6H44_RS05250	COG0271	Belongs to the BolA IbaG family
I6H44_RS05265	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6H44_RS05270	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6H44_RS05275	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6H44_RS05285	COG1477	protein flavinylation
I6H44_RS05290	COG2991	Protein conserved in bacteria
I6H44_RS05295	COG1942	4-Oxalocrotonate Tautomerase
I6H44_RS05300	COG0482	sulfurtransferase activity
I6H44_RS05320	COG0248	Ppx GppA phosphatase
I6H44_RS05325	COG2911	Protein conserved in bacteria
I6H44_RS05330	COG0729	surface antigen
I6H44_RS05335	COG2197	response regulator
I6H44_RS05345	COG0181	hydroxymethylbilane synthase activity
I6H44_RS05355	COG2959	enzyme of heme biosynthesis
I6H44_RS05360	COG3071	HemY protein
I6H44_RS05365	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6H44_RS05375	COG1496	oxidoreductase activity
I6H44_RS05390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H44_RS05410	COG0006	proline dipeptidase activity
I6H44_RS05435	COG0584	glycerophosphoryl diester phosphodiesterase
I6H44_RS05440	COG2271	Major facilitator Superfamily
I6H44_RS05450	COG0557	exoribonuclease II activity
I6H44_RS05455	COG1077	Cell shape determining protein MreB Mrl
I6H44_RS05460	COG1792	Involved in formation and maintenance of cell shape
I6H44_RS05465	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6H44_RS05470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H44_RS05475	COG2183	response to ionizing radiation
I6H44_RS05495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H44_RS05505	COG0765	amino acid transport
I6H44_RS05515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H44_RS05530	COG0583	DNA-binding transcription factor activity
I6H44_RS05535	COG2962	Rard protein
I6H44_RS05550	COG0551	DNA topoisomerase type I activity
I6H44_RS05565	COG0012	GTP binding
I6H44_RS05570	COG0193	aminoacyl-tRNA hydrolase activity
I6H44_RS05580	COG0560	Phosphoserine phosphatase
I6H44_RS05595	COG0728	peptidoglycan biosynthetic process
I6H44_RS05600	COG0196	riboflavin kinase activity
I6H44_RS05610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H44_RS05615	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6H44_RS05620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H44_RS05625	COG1116	anion transmembrane transporter activity
I6H44_RS05645	COG3091	SprT-like family
I6H44_RS05655	COG3063	Type IV pilus biogenesis stability protein PilW
I6H44_RS05660	COG1426	Protein conserved in bacteria
I6H44_RS05675	COG2976	Protein conserved in bacteria
I6H44_RS05685	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H44_RS05690	COG2233	PERMEase
I6H44_RS05700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H44_RS05705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6H44_RS05715	COG0659	secondary active sulfate transmembrane transporter activity
I6H44_RS05720	COG0800	Aldolase
I6H44_RS05725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H44_RS05730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6H44_RS05735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H44_RS05745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6H44_RS05750	COG1555	photosystem II stabilization
I6H44_RS05765	COG0705	Rhomboid family
I6H44_RS05770	COG1349	DNA-binding transcription factor activity
I6H44_RS05775	COG4206	TonB-dependent receptor
I6H44_RS05775	COG1629	transport
I6H44_RS05875	COG0582	viral genome integration into host DNA
I6H44_RS05885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H44_RS05895	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H44_RS05900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6H44_RS05915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H44_RS05920	COG3115	cell septum assembly
I6H44_RS05930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H44_RS05935	COG1573	uracil-dna glycosylase
I6H44_RS05945	COG3266	domain, Protein
I6H44_RS05945	COG3061	Opacity-associated protein A
I6H44_RS05950	COG1509	lysine 2,3-aminomutase activity
I6H44_RS05960	COG5413	integral membrane protein
I6H44_RS05970	COG0204	Acyl-transferase
I6H44_RS05985	COG3266	domain, Protein
I6H44_RS05990	COG4783	chaperone-mediated protein folding
I6H44_RS05995	COG0697	spore germination
I6H44_RS06000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H44_RS06005	COG1882	Formate acetyltransferase
I6H44_RS06010	COG2116	formate transmembrane transporter activity
I6H44_RS06015	COG0537	adenosine 5'-monophosphoramidase activity
I6H44_RS06045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H44_RS06060	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H44_RS06080	COG0583	DNA-binding transcription factor activity
I6H44_RS06085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H44_RS06105	COG0681	Belongs to the peptidase S26 family
I6H44_RS06130	COG2226	methyltransferase
I6H44_RS06140	COG0592	DNA-directed DNA polymerase activity
I6H44_RS06185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H44_RS06190	COG1115	amino acid carrier protein
I6H44_RS06205	COG0237	dephospho-CoA kinase activity
I6H44_RS06205	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6H44_RS06215	COG1459	type II secretion system
I6H44_RS06220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H44_RS06225	COG4969	Belongs to the N-Me-Phe pilin family
I6H44_RS06230	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6H44_RS06240	COG2116	formate transmembrane transporter activity
I6H44_RS06245	COG2731	YhcH YjgK YiaL family protein
I6H44_RS06255	COG4785	May be involved in cell division
I6H44_RS06260	COG0513	Belongs to the DEAD box helicase family
I6H44_RS06265	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6H44_RS06270	COG0312	modulator of DNA gyrase
I6H44_RS06275	COG3028	Belongs to the UPF0307 family
I6H44_RS06280	COG0471	metal ion transport
I6H44_RS06290	COG1575	Belongs to the MenA family. Type 1 subfamily
I6H44_RS06295	COG1720	tRNA m6t6A37 methyltransferase activity
I6H44_RS06300	COG0789	Transcriptional regulator
I6H44_RS06305	COG2608	mercury ion transmembrane transporter activity
I6H44_RS06310	COG2217	Heavy metal translocating P-type atpase
I6H44_RS06320	COG0740	serine-type endopeptidase activity
I6H44_RS06325	COG2194	sulfuric ester hydrolase activity
I6H44_RS06330	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H44_RS06330	COG2918	glutathione biosynthetic process
I6H44_RS06335	COG1702	phosphate starvation-inducible protein PhoH
I6H44_RS06340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H44_RS06345	COG1444	tRNA N-acetyltransferase activity
I6H44_RS06355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H44_RS06365	COG1530	ribonuclease E activity
I6H44_RS06370	COG0564	pseudouridine synthase activity
I6H44_RS06380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H44_RS06385	COG0626	cystathionine gamma-synthase activity
I6H44_RS06405	COG0527	aspartate kinase activity
I6H44_RS06415	COG2860	membrane
I6H44_RS06430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H44_RS06440	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6H44_RS06445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6H44_RS06450	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6H44_RS06455	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6H44_RS06460	COG2259	Doxx family
I6H44_RS06470	COG1611	Belongs to the LOG family
I6H44_RS06480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H44_RS06485	COG0745	RESPONSE REGULATOR receiver
I6H44_RS06495	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H44_RS06500	COG0697	spore germination
I6H44_RS06515	COG0142	geranyltranstransferase activity
I6H44_RS06525	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H44_RS06540	COG2056	Na+-H+ antiporter family
I6H44_RS06545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H44_RS06550	COG0346	lactoylglutathione lyase activity
I6H44_RS06555	COG4771	TonB-dependent receptor
I6H44_RS06565	COG4106	trans-aconitate 2-methyltransferase activity
I6H44_RS06570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H44_RS06585	COG0494	nUDIX hydrolase
I6H44_RS06595	COG0641	radical SAM
I6H44_RS06620	COG1271	oxidase subunit
I6H44_RS06625	COG1294	oxidase, subunit
I6H44_RS06635	COG0824	Thioesterase
I6H44_RS06640	COG0811	peptide transport
I6H44_RS06645	COG0848	biopolymer transport protein
I6H44_RS06650	COG3064	Membrane
I6H44_RS06680	COG2165	general secretion pathway protein
I6H44_RS06685	COG4795	General secretion pathway protein
I6H44_RS06700	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6H44_RS06705	COG0456	acetyltransferase
I6H44_RS06710	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6H44_RS06715	COG2813	Specifically methylates the guanine in position
I6H44_RS06725	COG0138	bifunctional purine biosynthesis protein purh
I6H44_RS06730	COG0151	Belongs to the GarS family
I6H44_RS06735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6H44_RS06740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H44_RS06745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6H44_RS06750	COG1862	Preprotein translocase
I6H44_RS06760	COG3945	hemerythrin HHE cation binding domain
I6H44_RS06775	COG0826	peptidase U32
I6H44_RS06785	COG3842	ATPase activity
I6H44_RS06795	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H44_RS06800	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H44_RS06860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H44_RS06870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H44_RS06890	COG0814	amino acid
I6H44_RS06920	COG1136	(ABC) transporter
I6H44_RS06930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6H44_RS06970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H44_RS06975	COG0778	Nitroreductase
I6H44_RS06990	COG2268	Band 7 protein
I6H44_RS06995	COG0114	fumarate hydratase activity
I6H44_RS07000	COG2927	DNA polymerase III (CHI subunit)
I6H44_RS07020	COG0494	nUDIX hydrolase
I6H44_RS07030	COG3550	peptidyl-serine autophosphorylation
I6H44_RS07040	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H44_RS07045	COG2814	Major facilitator Superfamily
I6H44_RS07050	COG1566	PFAM secretion protein HlyD family protein
I6H44_RS07055	COG0783	Belongs to the Dps family
I6H44_RS07065	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6H44_RS07085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H44_RS07105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H44_RS07110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H44_RS07115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H44_RS07120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H44_RS07125	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
I6H44_RS07130	COG0310	cobalt ion transport
I6H44_RS07135	COG0310	cobalt ion transport
I6H44_RS07140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6H44_RS07145	COG1122	ATPase activity
I6H44_RS07150	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6H44_RS07155	COG0409	Hydrogenase expression formation protein
I6H44_RS07160	COG0309	Hydrogenase expression formation protein (HypE)
I6H44_RS07170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H44_RS07175	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6H44_RS07180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6H44_RS07185	COG0795	lipopolysaccharide-transporting ATPase activity
I6H44_RS07190	COG0795	lipopolysaccharide-transporting ATPase activity
I6H44_RS07195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6H44_RS07200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H44_RS07210	COG0739	heme binding
I6H44_RS07215	COG4604	ABC transporter, ATP-binding protein
I6H44_RS07220	COG4605	iron ion homeostasis
I6H44_RS07225	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H44_RS07230	COG4607	ABC-type enterochelin transport system periplasmic component
I6H44_RS07235	COG4771	TonB-dependent receptor
I6H44_RS07235	COG1629	transport
I6H44_RS07240	COG0737	Belongs to the 5'-nucleotidase family
I6H44_RS07250	COG0436	Aminotransferase
I6H44_RS07255	COG3111	PFAM Bacterial OB fold (BOF) protein
I6H44_RS07260	COG0745	RESPONSE REGULATOR receiver
I6H44_RS07265	COG0642	Histidine kinase
I6H44_RS07275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H44_RS07290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H44_RS07295	COG0385	Bile acid
I6H44_RS07310	COG0351	phosphomethylpyrimidine kinase
I6H44_RS07315	COG4143	(ABC) transporter
I6H44_RS07320	COG1178	ABC-type Fe3 transport system permease component
I6H44_RS07325	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6H44_RS07335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H44_RS07335	COG2190	(PTS) system
I6H44_RS07335	COG1263	PTS System
I6H44_RS07345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6H44_RS07345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6H44_RS07350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6H44_RS07355	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6H44_RS07365	COG1737	Transcriptional regulator
I6H44_RS07370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H44_RS07375	COG0363	glucosamine-6-phosphate deaminase activity
I6H44_RS07380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6H44_RS07385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6H44_RS07395	COG0277	FAD linked oxidase domain protein
I6H44_RS07395	COG0247	lactate metabolic process
I6H44_RS07405	COG1704	LemA family
I6H44_RS07415	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6H44_RS07430	COG2363	Small membrane protein
I6H44_RS07435	COG1643	Atp-dependent helicase
I6H44_RS07460	COG2814	Major facilitator Superfamily
I6H44_RS07465	COG0375	protein maturation
I6H44_RS07475	COG2252	PERMEase
I6H44_RS07490	COG0825	malonyl-CoA metabolic process
I6H44_RS07655	COG1802	Transcriptional regulator
I6H44_RS07655	COG4626	Terminase
I6H44_RS07775	COG0582	viral genome integration into host DNA
I6H44_RS08070	COG0582	viral genome integration into host DNA
I6H44_RS08085	COG3069	C4-dicarboxylate transmembrane transporter activity
I6H44_RS08090	COG2233	PERMEase
I6H44_RS08100	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6H44_RS08100	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6H44_RS08140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H44_RS08145	COG0577	efflux transmembrane transporter activity
I6H44_RS08145	COG1136	(ABC) transporter
I6H44_RS08155	COG0577	efflux transmembrane transporter activity
I6H44_RS08170	COG0672	)-iron permease
I6H44_RS08175	COG1556	Lactate utilization protein
I6H44_RS08180	COG1139	Iron-sulfur cluster binding protein
I6H44_RS08185	COG0247	lactate metabolic process
I6H44_RS08190	COG1620	l-lactate permease
I6H44_RS08195	COG0277	FAD linked oxidase domain protein
I6H44_RS08200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H44_RS08205	COG3112	Uncharacterised protein family (UPF0231)
I6H44_RS08210	COG0316	Belongs to the HesB IscA family
I6H44_RS08215	COG0024	Methionine aminopeptidase
I6H44_RS08225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6H44_RS08230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H44_RS08275	COG0330	HflC and HflK could
I6H44_RS08285	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6H44_RS08290	COG3381	protein complex oligomerization
I6H44_RS08295	COG1560	Kdo2-lipid A biosynthetic process
I6H44_RS08300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6H44_RS08300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6H44_RS08305	COG2166	iron-sulfur cluster assembly
I6H44_RS08310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H44_RS08315	COG1525	nuclease
I6H44_RS08330	COG1346	cytolysis
I6H44_RS08340	COG0488	(ABC) transporter
I6H44_RS08345	COG0733	neurotransmitter:sodium symporter activity
I6H44_RS08350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H44_RS08370	COG4656	Part of a membrane complex involved in electron transport
I6H44_RS08380	COG4657	Part of a membrane complex involved in electron transport
I6H44_RS08385	COG1090	epimerase
I6H44_RS08400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H44_RS08405	COG0583	DNA-binding transcription factor activity
I6H44_RS08415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H44_RS08420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H44_RS08420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H44_RS08425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H44_RS08435	COG2005	Transcriptional regulator
I6H44_RS08440	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6H44_RS08445	COG4149	molybdate abc transporter
I6H44_RS08450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6H44_RS08455	COG2864	formate dehydrogenase
I6H44_RS08460	COG0437	4 iron, 4 sulfur cluster binding
I6H44_RS08475	COG0210	DNA helicase
I6H44_RS08480	COG1621	beta-fructofuranosidase activity
I6H44_RS08485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H44_RS08500	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6H44_RS08505	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6H44_RS08525	COG1410	methionine synthase
I6H44_RS08525	COG0646	methionine synthase
I6H44_RS08530	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6H44_RS08535	COG1136	(ABC) transporter
I6H44_RS08540	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6H44_RS08545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H44_RS08550	COG0305	Participates in initiation and elongation during chromosome replication
I6H44_RS08565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H44_RS08575	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6H44_RS08580	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6H44_RS08585	COG1280	lysine exporter protein (LysE YggA)
I6H44_RS08595	COG0633	Ferredoxin
I6H44_RS08600	COG0471	metal ion transport
I6H44_RS08605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H44_RS08615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H44_RS08645	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H44_RS08655	COG3842	ATPase activity
I6H44_RS08660	COG3099	Belongs to the UPF0263 family
I6H44_RS08670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H44_RS08675	COG2949	membrane
I6H44_RS08685	COG0440	acetolactate synthase activity
I6H44_RS08690	COG0028	Belongs to the TPP enzyme family
I6H44_RS08695	COG1757	Na H antiporter
I6H44_RS08700	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6H44_RS08705	COG0788	formyltetrahydrofolate deformylase activity
I6H44_RS08715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H44_RS08720	COG3101	peptidyl-lysine hydroxylation
I6H44_RS08730	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I6H44_RS08735	COG3098	single-species biofilm formation
I6H44_RS08750	COG1278	Cold shock
I6H44_RS08760	COG1067	ATP-dependent peptidase activity
I6H44_RS08765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6H44_RS08775	COG2252	PERMEase
I6H44_RS08785	COG1074	ATP-dependent DNA helicase activity
I6H44_RS08790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H44_RS08795	COG4106	trans-aconitate 2-methyltransferase activity
I6H44_RS08810	COG0101	tRNA pseudouridine synthase activity
I6H44_RS08815	COG0471	metal ion transport
I6H44_RS08820	COG2315	Protein conserved in bacteria
I6H44_RS08850	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H44_RS08855	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6H44_RS08860	COG0314	molybdopterin synthase activity
I6H44_RS08870	COG2969	positive regulation of protein catabolic process
I6H44_RS08880	COG1940	carbohydrate kinase activity
I6H44_RS08880	COG1846	Transcriptional regulator
I6H44_RS08890	COG0469	pyruvate kinase activity
I6H44_RS08900	COG0133	tryptophan synthase activity
I6H44_RS08905	COG4221	oxidoreductase activity
I6H44_RS08920	COG3630	sodium ion export across plasma membrane
I6H44_RS08930	COG0298	carbon dioxide binding
I6H44_RS08935	COG1773	rubredoxin
I6H44_RS08940	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6H44_RS08945	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6H44_RS08950	COG5557	Pfam Polysulphide reductase, NrfD
I6H44_RS08955	COG0437	4 iron, 4 sulfur cluster binding
I6H44_RS08960	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6H44_RS08965	COG0135	phosphoribosylanthranilate isomerase activity
I6H44_RS08965	COG0134	indole-3-glycerol-phosphate synthase activity
I6H44_RS08975	COG1942	4-Oxalocrotonate Tautomerase
I6H44_RS08980	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H44_RS08985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H44_RS08990	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6H44_RS08995	COG0517	IMP dehydrogenase activity
I6H44_RS08995	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6H44_RS09015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6H44_RS09030	COG0791	NLP P60 protein
I6H44_RS09050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H44_RS09055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H44_RS09060	COG1120	ATPase activity
I6H44_RS09070	COG3585	molybdate ion transport
I6H44_RS09080	COG1120	ATPase activity
I6H44_RS09085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H44_RS09090	COG1448	Aminotransferase
I6H44_RS09095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6H44_RS09100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H44_RS09105	COG0308	aminopeptidase N
I6H44_RS09110	COG0167	dihydroorotate dehydrogenase activity
I6H44_RS09115	COG0613	PHP domain protein
I6H44_RS09120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H44_RS09125	COG0589	response to stress
I6H44_RS09130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H44_RS09140	COG1528	Iron-storage protein
I6H44_RS09145	COG1528	Iron-storage protein
I6H44_RS09150	COG2925	Exonuclease
I6H44_RS09155	COG0697	spore germination
I6H44_RS09165	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6H44_RS09170	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6H44_RS09180	COG1686	Belongs to the peptidase S11 family
I6H44_RS09200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6H44_RS09205	COG0586	Pfam SNARE associated Golgi protein
I6H44_RS09210	COG0058	SHG alpha-glucan phosphorylase activity
I6H44_RS09225	COG1523	belongs to the glycosyl hydrolase 13 family
I6H44_RS09235	COG1640	4-alpha-glucanotransferase
I6H44_RS09245	COG0402	S-adenosylhomocysteine deaminase activity
I6H44_RS09250	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6H44_RS09380	COG3210	domain, Protein
I6H44_RS09385	COG2831	hemolysin activation secretion protein
I6H44_RS09395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H44_RS09400	COG1136	(ABC) transporter
I6H44_RS09400	COG0577	efflux transmembrane transporter activity
I6H44_RS09405	COG1538	Outer membrane efflux protein
I6H44_RS09415	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H44_RS09425	COG0564	pseudouridine synthase activity
I6H44_RS09430	COG2431	L-lysine efflux transmembrane transporter activity
I6H44_RS09435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H44_RS09440	COG0406	alpha-ribazole phosphatase activity
I6H44_RS09445	COG0285	dihydrofolate synthase activity
I6H44_RS09455	COG2819	hydrolase of the alpha beta superfamily
I6H44_RS09465	COG0142	geranyltranstransferase activity
I6H44_RS09475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H44_RS09480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H44_RS09505	COG0616	signal peptide processing
I6H44_RS09565	COG1252	NADH dehydrogenase
I6H44_RS09575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H44_RS09580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H44_RS09585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6H44_RS09595	COG0792	nuclease activity
I6H44_RS09600	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6H44_RS09605	COG2823	Periplasmic or secreted lipoprotein
I6H44_RS09610	COG0288	reversible hydration of carbon dioxide
I6H44_RS09615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H44_RS09615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H44_RS09620	COG0785	Cytochrome C biogenesis protein
I6H44_RS09625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H44_RS09630	COG3955	Domain of unknown function (DUF1919)
I6H44_RS09635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H44_RS09640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H44_RS09645	COG4178	(ABC) transporter
I6H44_RS09650	COG4774	siderophore transport
I6H44_RS09660	COG0307	riboflavin synthase, alpha
I6H44_RS09665	COG1534	Rna-binding protein
I6H44_RS09670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H44_RS09675	COG2027	D-alanyl-D-alanine carboxypeptidase
I6H44_RS09685	COG0303	'Molybdopterin
I6H44_RS09690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6H44_RS09705	COG1286	toxin biosynthetic process
I6H44_RS09715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H44_RS09720	COG0857	belongs to the CobB CobQ family
I6H44_RS09720	COG0280	phosphate acetyltransferase
I6H44_RS09725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6H44_RS09730	COG0617	tRNA 3'-terminal CCA addition
I6H44_RS09735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6H44_RS09740	COG2333	competence protein COMEC
I6H44_RS09740	COG0658	competence protein
I6H44_RS09750	COG1663	tetraacyldisaccharide 4'-kinase activity
I6H44_RS09765	COG0322	excinuclease ABC activity
I6H44_RS09770	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6H44_RS09785	COG4206	TonB-dependent receptor
I6H44_RS09790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H44_RS09795	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H44_RS09805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H44_RS09810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H44_RS09815	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H44_RS09820	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6H44_RS09835	COG0583	DNA-binding transcription factor activity
I6H44_RS09845	COG0009	L-threonylcarbamoyladenylate synthase
I6H44_RS09850	COG1605	Chorismate mutase
I6H44_RS09850	COG0287	Prephenate dehydrogenase
I6H44_RS09855	COG0616	signal peptide processing
I6H44_RS09860	COG0778	Nitroreductase
I6H44_RS09870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H44_RS09875	COG0640	Transcriptional regulator
I6H44_RS09880	COG1088	dTDP-glucose 4,6-dehydratase activity
I6H44_RS09885	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6H44_RS09890	COG0708	Exodeoxyribonuclease III
I6H44_RS09895	COG2951	lytic endotransglycosylase activity
I6H44_RS09900	COG1216	Glycosyl transferase, family 2
I6H44_RS09905	COG1216	Glycosyl transferase, family 2
I6H44_RS09915	COG3306	glycosyltransferase involved in LPS biosynthesis
I6H44_RS09925	COG5039	Polysaccharide pyruvyl transferase
I6H44_RS09930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6H44_RS09935	COG1793	dna ligase
I6H44_RS09945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H44_RS09950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H44_RS09955	COG0195	Participates in both transcription termination and antitermination
I6H44_RS09970	COG3100	YcgL domain-containing protein
I6H44_RS09985	COG2062	phosphohistidine phosphatase, SixA
I6H44_RS09995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6H44_RS10000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H44_RS10015	COG2932	Transcriptional regulator
I6H44_RS10020	COG0791	NLP P60 protein
I6H44_RS10030	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H44_RS10035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H44_RS10040	COG3133	Outer membrane lipoprotein
I6H44_RS10045	COG3102	Protein conserved in bacteria