locus-tag	class	description
J5A60_RS00010	COG3074	FtsZ-dependent cytokinesis
J5A60_RS00015	COG1494	fructose-1,6-bisphosphatase
J5A60_RS00020	COG1045	serine acetyltransferase
J5A60_RS00030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J5A60_RS00035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5A60_RS00040	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
J5A60_RS00045	COG4988	ABC transporter
J5A60_RS00050	COG1132	(ABC) transporter
J5A60_RS00060	COG0733	neurotransmitter:sodium symporter activity
J5A60_RS00070	COG1285	pathogenesis
J5A60_RS00080	COG3276	selenocysteine insertion sequence binding
J5A60_RS00085	COG1921	L-seryl-tRNASec selenium transferase activity
J5A60_RS00090	COG0442	prolyl-tRNA aminoacylation
J5A60_RS00105	COG1595	DNA-templated transcription, initiation
J5A60_RS00110	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
J5A60_RS00115	COG3026	antisigma factor binding
J5A60_RS00120	COG3086	response to oxidative stress
J5A60_RS00125	COG1763	Mo-molybdopterin cofactor biosynthetic process
J5A60_RS00130	COG2814	Major facilitator Superfamily
J5A60_RS00145	COG3070	regulator of competence-specific genes
J5A60_RS00175	COG0513	Belongs to the DEAD box helicase family
J5A60_RS00185	COG3201	nicotinamide mononucleotide transporter
J5A60_RS00210	COG1238	metal cluster binding
J5A60_RS00215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5A60_RS00240	COG0210	DNA helicase
J5A60_RS00245	COG5645	(Lipo)protein
J5A60_RS00255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5A60_RS00255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5A60_RS00265	COG0702	epimerase
J5A60_RS00270	COG1733	regulation of RNA biosynthetic process
J5A60_RS00275	COG0752	glycyl-tRNA synthetase alpha subunit
J5A60_RS00285	COG4545	Glutaredoxin-related protein
J5A60_RS00300	COG2852	Protein conserved in bacteria
J5A60_RS00310	COG0751	glycine-tRNA ligase activity
J5A60_RS00320	COG0805	protein transport
J5A60_RS00325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5A60_RS00330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5A60_RS00335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J5A60_RS00340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J5A60_RS00345	COG1011	Hydrolase
J5A60_RS00350	COG0494	nUDIX hydrolase
J5A60_RS00360	COG3059	membrane
J5A60_RS00365	COG1297	OPT oligopeptide transporter protein
J5A60_RS00375	COG1218	3'(2'),5'-bisphosphate nucleotidase
J5A60_RS00380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J5A60_RS00385	COG0363	glucosamine-6-phosphate deaminase activity
J5A60_RS00430	COG2853	Lipoprotein
J5A60_RS00445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5A60_RS00450	COG2354	Protein conserved in bacteria
J5A60_RS00500	COG4942	peptidase
J5A60_RS00505	COG2861	carbohydrate metabolic process
J5A60_RS00510	COG0606	chelatase, subunit chli
J5A60_RS00520	COG2990	Protein conserved in bacteria
J5A60_RS00525	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J5A60_RS00540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J5A60_RS00545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J5A60_RS00590	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
J5A60_RS00610	COG0459	protein refolding
J5A60_RS00615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J5A60_RS00620	COG3030	protein affecting phage T7 exclusion by the F plasmid
J5A60_RS00625	COG1027	Aspartate ammonia-lyase
J5A60_RS00630	COG0859	PFAM glycosyl transferase family 9
J5A60_RS00635	COG2364	Membrane
J5A60_RS00640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J5A60_RS00660	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
J5A60_RS00665	COG1522	sequence-specific DNA binding
J5A60_RS00680	COG0038	chloride channel
J5A60_RS00685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J5A60_RS00690	COG0549	Belongs to the carbamate kinase family
J5A60_RS00695	COG1288	antiporter activity
J5A60_RS00700	COG1522	sequence-specific DNA binding
J5A60_RS00705	COG0051	transcription antitermination factor activity, RNA binding
J5A60_RS00710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J5A60_RS00715	COG0088	Forms part of the polypeptide exit tunnel
J5A60_RS00720	COG0089	rRNA binding
J5A60_RS00725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J5A60_RS00730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J5A60_RS00735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J5A60_RS00740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J5A60_RS00745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J5A60_RS00750	COG0255	Belongs to the universal ribosomal protein uL29 family
J5A60_RS00755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J5A60_RS00770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J5A60_RS00780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J5A60_RS00790	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J5A60_RS00810	COG0201	protein transport
J5A60_RS00830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J5A60_RS00845	COG0463	Glycosyl transferase, family 2
J5A60_RS00850	COG1519	Transferase
J5A60_RS00860	COG3642	lipopolysaccharide core region biosynthetic process
J5A60_RS00865	COG0859	PFAM glycosyl transferase family 9
J5A60_RS00870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J5A60_RS00875	COG1917	Cupin 2, conserved barrel domain protein
J5A60_RS00875	COG4977	sequence-specific DNA binding
J5A60_RS00880	COG1132	(ABC) transporter
J5A60_RS00885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J5A60_RS00890	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J5A60_RS00895	COG1011	Hydrolase
J5A60_RS00970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J5A60_RS00980	COG1028	Short-chain dehydrogenase reductase Sdr
J5A60_RS00985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J5A60_RS01005	COG0842	Transport permease protein
J5A60_RS01010	COG1131	(ABC) transporter
J5A60_RS01025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J5A60_RS01035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J5A60_RS01055	COG0028	Belongs to the TPP enzyme family
J5A60_RS01065	COG0561	phosphatase activity
J5A60_RS01070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J5A60_RS01075	COG2267	carboxylic ester hydrolase activity
J5A60_RS01080	COG0191	fructose-bisphosphate aldolase activity
J5A60_RS01090	COG3719	Belongs to the RNase T2 family
J5A60_RS01095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J5A60_RS01100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5A60_RS01105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5A60_RS01110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J5A60_RS01130	COG0778	Nitroreductase
J5A60_RS01135	COG2249	NAD(P)H dehydrogenase (quinone) activity
J5A60_RS01140	COG0338	D12 class N6 adenine-specific DNA methyltransferase
J5A60_RS01145	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J5A60_RS01150	COG4796	Type ii and iii secretion system protein
J5A60_RS01170	COG4972	Pilus assembly protein
J5A60_RS01175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J5A60_RS01180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J5A60_RS01185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5A60_RS01210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J5A60_RS01240	COG3306	glycosyltransferase involved in LPS biosynthesis
J5A60_RS01250	COG3306	glycosyltransferase involved in LPS biosynthesis
J5A60_RS01260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
J5A60_RS01270	COG1216	Glycosyl transferase, family 2
J5A60_RS01270	COG1442	glycosyl transferase family 8
J5A60_RS01275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J5A60_RS01280	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J5A60_RS01285	COG1309	transcriptional regulator
J5A60_RS01290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5A60_RS01295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J5A60_RS01300	COG0500	methyltransferase
J5A60_RS01310	COG0762	integral membrane protein
J5A60_RS01320	COG0778	Nitroreductase
J5A60_RS01325	COG1368	sulfuric ester hydrolase activity
J5A60_RS01335	COG1595	DNA-templated transcription, initiation
J5A60_RS01340	COG0758	DNA mediated transformation
J5A60_RS01375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J5A60_RS01380	COG4137	Cytochrome C assembly protein
J5A60_RS01385	COG4536	flavin adenine dinucleotide binding
J5A60_RS01390	COG0811	peptide transport
J5A60_RS01395	COG0848	biopolymer transport protein
J5A60_RS01400	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
J5A60_RS01405	COG4783	chaperone-mediated protein folding
J5A60_RS01415	COG0814	amino acid
J5A60_RS01420	COG2226	methyltransferase
J5A60_RS01430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J5A60_RS01445	COG4178	(ABC) transporter
J5A60_RS01460	COG0233	cytoplasmic translational termination
J5A60_RS01475	COG0575	Belongs to the CDS family
J5A60_RS01500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J5A60_RS01520	COG0471	metal ion transport
J5A60_RS01520	COG0490	domain, Protein
J5A60_RS01525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J5A60_RS01535	COG4589	Belongs to the CDS family
J5A60_RS01540	COG0521	Mo-molybdopterin cofactor biosynthetic process
J5A60_RS01550	COG2966	Psort location CytoplasmicMembrane, score
J5A60_RS01555	COG3610	response to peptide
J5A60_RS01560	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J5A60_RS01565	COG1253	flavin adenine dinucleotide binding
J5A60_RS01575	COG0084	hydrolase, TatD family'
J5A60_RS01580	COG0470	DNA polymerase III
J5A60_RS01585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J5A60_RS01590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J5A60_RS01595	COG0628	permease
J5A60_RS01605	COG0545	Peptidyl-prolyl cis-trans isomerase
J5A60_RS01610	COG0688	phosphatidylethanolamine metabolic process
J5A60_RS01615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J5A60_RS01625	COG2830	Protein of unknown function (DUF452)
J5A60_RS01630	COG2226	methyltransferase
J5A60_RS01640	COG1399	metal-binding, possibly nucleic acid-binding protein
J5A60_RS01660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J5A60_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
J5A60_RS01675	COG2814	Major facilitator Superfamily
J5A60_RS01680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J5A60_RS01685	COG0513	Belongs to the DEAD box helicase family
J5A60_RS01690	COG0799	negative regulation of ribosome biogenesis
J5A60_RS01700	COG0768	penicillin binding
J5A60_RS01705	COG0772	Belongs to the SEDS family
J5A60_RS01715	COG1686	Belongs to the peptidase S11 family
J5A60_RS01740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J5A60_RS01745	COG0084	hydrolase, TatD family'
J5A60_RS01750	COG0602	queuosine metabolic process
J5A60_RS01755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J5A60_RS01755	COG1328	CTP reductase activity
J5A60_RS01760	COG1022	Amp-dependent synthetase and ligase
J5A60_RS01765	COG0587	DNA-directed DNA polymerase activity
J5A60_RS01770	COG0121	glutamine amidotransferase
J5A60_RS01775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J5A60_RS01810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5A60_RS01820	COG0494	nUDIX hydrolase
J5A60_RS01825	COG0730	response to heat
J5A60_RS01835	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J5A60_RS01840	COG0590	tRNA wobble adenosine to inosine editing
J5A60_RS01845	COG3078	GTPase activator activity
J5A60_RS01855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J5A60_RS01860	COG0456	acetyltransferase
J5A60_RS01865	COG0149	triose-phosphate isomerase activity
J5A60_RS01870	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J5A60_RS01885	COG0511	ligase activity, forming carbon-carbon bonds
J5A60_RS01890	COG0439	Biotin carboxylase
J5A60_RS01910	COG3924	membrane
J5A60_RS01915	COG4145	pantothenate transmembrane transporter activity
J5A60_RS01965	COG2267	carboxylic ester hydrolase activity
J5A60_RS01970	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
J5A60_RS01980	COG0436	Aminotransferase
J5A60_RS01995	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J5A60_RS02010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J5A60_RS02025	COG0281	malic enzyme
J5A60_RS02025	COG0280	phosphate acetyltransferase
J5A60_RS02035	COG2814	Major facilitator Superfamily
J5A60_RS02040	COG4133	protoheme IX ABC transporter activity
J5A60_RS02045	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5A60_RS02050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5A60_RS02055	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5A60_RS02065	COG1138	Cytochrome C-type biogenesis protein
J5A60_RS02070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5A60_RS02090	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
J5A60_RS02095	COG0437	4 iron, 4 sulfur cluster binding
J5A60_RS02100	COG3301	Polysulphide reductase, NrfD
J5A60_RS02105	COG1138	Cytochrome C-type biogenesis protein
J5A60_RS02110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5A60_RS02115	COG4235	cytochrome complex assembly
J5A60_RS02115	COG3088	subunit of a heme lyase
J5A60_RS02120	COG2081	HI0933 family
J5A60_RS02135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J5A60_RS02140	COG2814	Major facilitator Superfamily
J5A60_RS02145	COG4974	Belongs to the 'phage' integrase family
J5A60_RS02155	COG0330	HflC and HflK could
J5A60_RS02160	COG0330	HflC and HflK could
J5A60_RS02165	COG2091	lysine biosynthetic process via aminoadipic acid
J5A60_RS02170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J5A60_RS02180	COG0460	homoserine dehydrogenase
J5A60_RS02180	COG0527	aspartate kinase activity
J5A60_RS02185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J5A60_RS02200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J5A60_RS02210	COG1217	gtp-binding protein TYPA
J5A60_RS02215	COG0174	glutamine synthetase
J5A60_RS02220	COG0861	Integral membrane protein TerC family
J5A60_RS02230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J5A60_RS02235	COG2067	long-chain fatty acid transport protein
J5A60_RS02240	COG3691	Protein conserved in bacteria
J5A60_RS02250	COG5007	Belongs to the BolA IbaG family
J5A60_RS02255	COG3113	response to antibiotic
J5A60_RS02260	COG2854	intermembrane phospholipid transfer
J5A60_RS02265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J5A60_RS02270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J5A60_RS02275	COG1127	ABC transporter
J5A60_RS02280	COG3117	lipopolysaccharide transmembrane transporter activity
J5A60_RS02285	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J5A60_RS02290	COG1137	ATPase activity
J5A60_RS02295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5A60_RS02310	COG2850	peptidyl-arginine hydroxylation
J5A60_RS02315	COG2914	Belongs to the UPF0125 (RnfH) family
J5A60_RS02325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J5A60_RS02335	COG1758	RNA polymerase activity
J5A60_RS02340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J5A60_RS02350	COG3161	chorismate lyase activity
J5A60_RS02355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J5A60_RS02390	COG1126	abc transporter atp-binding protein
J5A60_RS02395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5A60_RS02400	COG4215	(ABC) transporter
J5A60_RS02405	COG4160	amino acid transport
J5A60_RS02415	COG1966	Carbon starvation protein
J5A60_RS02430	COG3116	cell division
J5A60_RS02435	COG0768	penicillin binding
J5A60_RS02440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J5A60_RS02445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J5A60_RS02455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J5A60_RS02480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J5A60_RS02485	COG0849	cell division
J5A60_RS02490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J5A60_RS02495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
J5A60_RS02505	COG1605	Chorismate mutase
J5A60_RS02505	COG0077	Prephenate dehydratase
J5A60_RS02510	COG0326	Molecular chaperone. Has ATPase activity
J5A60_RS02515	COG1393	Belongs to the ArsC family
J5A60_RS02530	COG1876	peptidase activity
J5A60_RS02535	COG0494	nUDIX hydrolase
J5A60_RS02540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J5A60_RS02565	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
J5A60_RS02575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J5A60_RS02580	COG1053	succinate dehydrogenase
J5A60_RS02590	COG1120	ATPase activity
J5A60_RS02595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A60_RS02600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A60_RS02605	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
J5A60_RS02610	COG1408	metallophosphoesterase
J5A60_RS02630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J5A60_RS02655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5A60_RS02665	COG0741	lytic transglycosylase activity
J5A60_RS02670	COG2350	Protein conserved in bacteria
J5A60_RS02675	COG1607	acyl-coa hydrolase
J5A60_RS02690	COG0497	DNA recombination
J5A60_RS02700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J5A60_RS02705	COG1629	transport
J5A60_RS02705	COG4771	TonB-dependent receptor
J5A60_RS02715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5A60_RS02715	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
J5A60_RS02720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J5A60_RS02725	COG0784	Response regulator, receiver
J5A60_RS02725	COG2198	Histidine kinase
J5A60_RS02725	COG5002	protein histidine kinase activity
J5A60_RS02730	COG4211	Belongs to the binding-protein-dependent transport system permease family
J5A60_RS02735	COG1129	ABC transporter
J5A60_RS02740	COG1879	ABC-type sugar transport system periplasmic component
J5A60_RS02745	COG1609	Transcriptional regulator
J5A60_RS02750	COG1085	galactose-1-phosphate uridylyltransferase
J5A60_RS02755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
J5A60_RS02760	COG2017	converts alpha-aldose to the beta-anomer
J5A60_RS02765	COG4535	Mg2 and Co2 transporter CorC
J5A60_RS02770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
J5A60_RS02790	COG0489	protein tyrosine kinase activity
J5A60_RS02795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5A60_RS02795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5A60_RS02800	COG2975	iron-sulfur cluster assembly
J5A60_RS02805	COG0633	Ferredoxin
J5A60_RS02810	COG0443	Heat shock 70 kDa protein
J5A60_RS02815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J5A60_RS02825	COG0822	iron-sulfur transferase activity
J5A60_RS02835	COG1959	2 iron, 2 sulfur cluster binding
J5A60_RS02840	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
J5A60_RS02870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J5A60_RS02875	COG1530	ribonuclease E activity
J5A60_RS02885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J5A60_RS02905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5A60_RS02945	COG2855	membrane
J5A60_RS02950	COG4953	penicillin-binding protein 1C
J5A60_RS02960	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5A60_RS02965	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J5A60_RS02970	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J5A60_RS02980	COG4991	sh3 domain protein
J5A60_RS02985	COG0306	phosphate transporter
J5A60_RS02990	COG1392	Phosphate transport regulator
J5A60_RS02995	COG3025	triphosphatase activity
J5A60_RS03000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
J5A60_RS03010	COG1522	sequence-specific DNA binding
J5A60_RS03025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J5A60_RS03030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
J5A60_RS03045	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J5A60_RS03050	COG1177	transmembrane transport
J5A60_RS03055	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5A60_RS03060	COG3842	ATPase activity
J5A60_RS03075	COG3008	intermembrane lipid transfer
J5A60_RS03080	COG2995	paraquat-inducible protein a
J5A60_RS03085	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
J5A60_RS03090	COG0793	Belongs to the peptidase S41A family
J5A60_RS03095	COG2989	Protein conserved in bacteria
J5A60_RS03100	COG3108	Peptidase M15
J5A60_RS03105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5A60_RS03110	COG0567	Dehydrogenase, E1 component
J5A60_RS03115	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5A60_RS03125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J5A60_RS03140	COG1289	transmembrane transporter activity
J5A60_RS03145	COG3304	Inner membrane component domain
J5A60_RS03155	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
J5A60_RS03165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5A60_RS03170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5A60_RS03175	COG1121	(ABC) transporter
J5A60_RS03185	COG2920	part of a sulfur-relay system
J5A60_RS03195	COG1263	PTS System
J5A60_RS03195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J5A60_RS03195	COG2190	(PTS) system
J5A60_RS03205	COG0058	SHG alpha-glucan phosphorylase activity
J5A60_RS03210	COG2188	Transcriptional regulator
J5A60_RS03220	COG0583	DNA-binding transcription factor activity
J5A60_RS03225	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
J5A60_RS03230	COG1687	branched-chain amino acid
J5A60_RS03235	COG2990	Protein conserved in bacteria
J5A60_RS03240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J5A60_RS03245	COG0539	negative regulation of cytoplasmic translation
J5A60_RS03255	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
J5A60_RS03260	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J5A60_RS03270	COG0023	Translation Initiation Factor
J5A60_RS03275	COG3094	Invasion gene expression up-regulator, SirB
J5A60_RS03280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J5A60_RS03285	COG0735	belongs to the Fur family
J5A60_RS03290	COG0716	FMN binding
J5A60_RS03300	COG0596	Alpha beta hydrolase
J5A60_RS03305	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
J5A60_RS03310	COG0318	PFAM AMP-dependent synthetase and ligase
J5A60_RS03315	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
J5A60_RS03315	COG3264	Mechanosensitive ion channel
J5A60_RS03325	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
J5A60_RS03330	COG0730	response to heat
J5A60_RS03335	COG1560	Kdo2-lipid A biosynthetic process
J5A60_RS03345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J5A60_RS03360	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
J5A60_RS03370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J5A60_RS03375	COG0187	DNA topoisomerase II activity
J5A60_RS03380	COG1858	cytochrome C peroxidase
J5A60_RS03385	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
J5A60_RS03395	COG0488	(ABC) transporter
J5A60_RS03400	COG3683	transport system, periplasmic component
J5A60_RS03405	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
J5A60_RS03420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5A60_RS03425	COG3105	Protein conserved in bacteria
J5A60_RS03430	COG1944	ATP diphosphatase activity
J5A60_RS03440	COG3422	double-strand break repair
J5A60_RS03445	COG1263	PTS System
J5A60_RS03445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J5A60_RS03445	COG2190	(PTS) system
J5A60_RS03450	COG2226	methyltransferase
J5A60_RS03465	COG1846	Transcriptional regulator
J5A60_RS03465	COG1940	carbohydrate kinase activity
J5A60_RS03490	COG4172	Belongs to the ABC transporter superfamily
J5A60_RS03495	COG4172	Belongs to the ABC transporter superfamily
J5A60_RS03500	COG4171	peptide transport system, permease
J5A60_RS03505	COG4168	peptide transport system, permease
J5A60_RS03510	COG4166	transmembrane transport
J5A60_RS03515	COG3106	COG3106 Predicted ATPase
J5A60_RS03525	COG3283	Transcriptional regulator of aromatic amino acids metabolism
J5A60_RS03530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J5A60_RS03535	COG1923	regulation of RNA biosynthetic process
J5A60_RS03545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J5A60_RS03550	COG1388	LysM domain
J5A60_RS03550	COG0860	N-Acetylmuramoyl-L-alanine amidase
J5A60_RS03555	COG0802	atpase or kinase
J5A60_RS03580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5A60_RS03590	COG2190	(PTS) system
J5A60_RS03595	COG0339	signal peptide processing
J5A60_RS03600	COG2832	Protein of unknown function (DUF454)
J5A60_RS03605	COG4166	transmembrane transport
J5A60_RS03615	COG0671	phosphoesterase, PA-phosphatase related
J5A60_RS03635	COG0515	serine threonine protein kinase
J5A60_RS03640	COG2833	Protein of unknown function (DUF455)
J5A60_RS03645	COG1946	Acyl-CoA thioesterase
J5A60_RS03655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J5A60_RS03660	COG4988	ABC transporter
J5A60_RS03665	COG0492	ferredoxin-NADP+ reductase activity
J5A60_RS03670	COG3118	belongs to the thioredoxin family
J5A60_RS03695	COG3384	dioxygenase
J5A60_RS03705	COG0676	glucose-6-phosphate 1-epimerase activity
J5A60_RS03710	COG1199	ATP-dependent helicase activity
J5A60_RS03715	COG1214	PFAM Peptidase M22, glycoprotease
J5A60_RS03720	COG3065	identical protein binding
J5A60_RS03725	COG0318	PFAM AMP-dependent synthetase and ligase
J5A60_RS03730	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J5A60_RS03735	COG1858	cytochrome C peroxidase
J5A60_RS03755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J5A60_RS03760	COG0626	cystathionine gamma-synthase activity
J5A60_RS03770	COG0484	heat shock protein binding
J5A60_RS03785	COG0443	Heat shock 70 kDa protein
J5A60_RS03800	COG3102	Protein conserved in bacteria
J5A60_RS03805	COG3133	Outer membrane lipoprotein
J5A60_RS03810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J5A60_RS03815	COG2890	protein-(glutamine-N5) methyltransferase activity
J5A60_RS03825	COG0791	NLP P60 protein
J5A60_RS03830	COG2932	Transcriptional regulator
J5A60_RS03845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5A60_RS03850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J5A60_RS03860	COG2062	phosphohistidine phosphatase, SixA
J5A60_RS03875	COG3100	YcgL domain-containing protein
J5A60_RS03890	COG0195	Participates in both transcription termination and antitermination
J5A60_RS03895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J5A60_RS03900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J5A60_RS03910	COG1793	dna ligase
J5A60_RS03915	COG1434	Gram-negative-bacterium-type cell wall biogenesis
J5A60_RS03930	COG3306	glycosyltransferase involved in LPS biosynthesis
J5A60_RS03940	COG1216	Glycosyl transferase, family 2
J5A60_RS03945	COG1216	Glycosyl transferase, family 2
J5A60_RS03950	COG2951	lytic endotransglycosylase activity
J5A60_RS03955	COG0708	Exodeoxyribonuclease III
J5A60_RS03960	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
J5A60_RS03970	COG0640	Transcriptional regulator
J5A60_RS03985	COG0778	Nitroreductase
J5A60_RS03990	COG0616	signal peptide processing
J5A60_RS03995	COG0287	Prephenate dehydrogenase
J5A60_RS03995	COG1605	Chorismate mutase
J5A60_RS04000	COG0009	L-threonylcarbamoyladenylate synthase
J5A60_RS04010	COG0583	DNA-binding transcription factor activity
J5A60_RS04025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J5A60_RS04030	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5A60_RS04035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5A60_RS04040	COG0110	maltose O-acetyltransferase activity
J5A60_RS04045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5A60_RS04055	COG0512	Glutamine amidotransferase of anthranilate synthase
J5A60_RS04060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5A60_RS04065	COG4206	TonB-dependent receptor
J5A60_RS04075	COG1943	Transposase
J5A60_RS04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A60_RS04090	COG3842	ATPase activity
J5A60_RS04095	COG1175	transmembrane transport
J5A60_RS04100	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5A60_RS04110	COG0322	excinuclease ABC activity
J5A60_RS04125	COG1663	tetraacyldisaccharide 4'-kinase activity
J5A60_RS04135	COG0658	competence protein
J5A60_RS04135	COG2333	competence protein COMEC
J5A60_RS04140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J5A60_RS04145	COG0617	tRNA 3'-terminal CCA addition
J5A60_RS04150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J5A60_RS04155	COG0280	phosphate acetyltransferase
J5A60_RS04155	COG0857	belongs to the CobB CobQ family
J5A60_RS04160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J5A60_RS04170	COG1286	toxin biosynthetic process
J5A60_RS04185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J5A60_RS04190	COG0303	'Molybdopterin
J5A60_RS04200	COG2027	D-alanyl-D-alanine carboxypeptidase
J5A60_RS04205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J5A60_RS04210	COG1534	Rna-binding protein
J5A60_RS04215	COG0307	riboflavin synthase, alpha
J5A60_RS04225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J5A60_RS04230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J5A60_RS04235	COG3955	Domain of unknown function (DUF1919)
J5A60_RS04240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5A60_RS04245	COG0785	Cytochrome C biogenesis protein
J5A60_RS04250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5A60_RS04250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5A60_RS04255	COG0288	reversible hydration of carbon dioxide
J5A60_RS04260	COG2823	Periplasmic or secreted lipoprotein
J5A60_RS04265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
J5A60_RS04270	COG0792	nuclease activity
J5A60_RS04280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J5A60_RS04285	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J5A60_RS04290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J5A60_RS04300	COG1252	NADH dehydrogenase
J5A60_RS04310	COG0616	signal peptide processing
J5A60_RS04330	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J5A60_RS04335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J5A60_RS04345	COG0142	geranyltranstransferase activity
J5A60_RS04355	COG2819	hydrolase of the alpha beta superfamily
J5A60_RS04365	COG0285	dihydrofolate synthase activity
J5A60_RS04370	COG0406	alpha-ribazole phosphatase activity
J5A60_RS04375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5A60_RS04380	COG2431	L-lysine efflux transmembrane transporter activity
J5A60_RS04385	COG0564	pseudouridine synthase activity
J5A60_RS04395	COG2824	Alkylphosphonate utilization operon protein PhnA
J5A60_RS04400	COG1538	Outer membrane efflux protein
J5A60_RS04405	COG0577	efflux transmembrane transporter activity
J5A60_RS04405	COG1136	(ABC) transporter
J5A60_RS04410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5A60_RS04420	COG2831	hemolysin activation secretion protein
J5A60_RS04510	COG1652	LysM domain
J5A60_RS04515	COG2321	neutral zinc metallopeptidase
J5A60_RS04550	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
J5A60_RS04555	COG0402	S-adenosylhomocysteine deaminase activity
J5A60_RS04565	COG1640	4-alpha-glucanotransferase
J5A60_RS04575	COG1523	belongs to the glycosyl hydrolase 13 family
J5A60_RS04590	COG0058	SHG alpha-glucan phosphorylase activity
J5A60_RS04595	COG0586	Pfam SNARE associated Golgi protein
J5A60_RS04600	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J5A60_RS04620	COG1686	Belongs to the peptidase S11 family
J5A60_RS04630	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
J5A60_RS04635	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
J5A60_RS04645	COG0697	spore germination
J5A60_RS04650	COG2925	Exonuclease
J5A60_RS04655	COG1528	Iron-storage protein
J5A60_RS04660	COG1528	Iron-storage protein
J5A60_RS04670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J5A60_RS04675	COG0589	response to stress
J5A60_RS04680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J5A60_RS04685	COG0583	DNA-binding transcription factor activity
J5A60_RS04690	COG0613	PHP domain protein
J5A60_RS04700	COG0308	aminopeptidase N
J5A60_RS04705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J5A60_RS04710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J5A60_RS04715	COG1448	Aminotransferase
J5A60_RS04720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A60_RS04725	COG1120	ATPase activity
J5A60_RS04735	COG3585	molybdate ion transport
J5A60_RS04750	COG0791	NLP P60 protein
J5A60_RS04765	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J5A60_RS04785	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J5A60_RS04785	COG0517	IMP dehydrogenase activity
J5A60_RS04790	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J5A60_RS04795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J5A60_RS04800	COG0512	Glutamine amidotransferase of anthranilate synthase
J5A60_RS04805	COG1942	4-Oxalocrotonate Tautomerase
J5A60_RS04815	COG0134	indole-3-glycerol-phosphate synthase activity
J5A60_RS04815	COG0135	phosphoribosylanthranilate isomerase activity
J5A60_RS04820	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
J5A60_RS04825	COG0437	4 iron, 4 sulfur cluster binding
J5A60_RS04830	COG5557	Pfam Polysulphide reductase, NrfD
J5A60_RS04835	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
J5A60_RS04840	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
J5A60_RS04845	COG1773	rubredoxin
J5A60_RS04850	COG0298	carbon dioxide binding
J5A60_RS04865	COG3630	sodium ion export across plasma membrane
J5A60_RS04870	COG0511	ligase activity, forming carbon-carbon bonds
J5A60_RS04870	COG5016	pyruvate
J5A60_RS04880	COG4221	oxidoreductase activity
J5A60_RS04895	COG0469	pyruvate kinase activity
J5A60_RS04905	COG1846	Transcriptional regulator
J5A60_RS04905	COG1940	carbohydrate kinase activity
J5A60_RS04915	COG2969	positive regulation of protein catabolic process
J5A60_RS04925	COG0314	molybdopterin synthase activity
J5A60_RS04930	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J5A60_RS04935	COG0315	cyclic pyranopterin monophosphate synthase activity
J5A60_RS04965	COG2315	Protein conserved in bacteria
J5A60_RS04970	COG0471	metal ion transport
J5A60_RS04975	COG0101	tRNA pseudouridine synthase activity
J5A60_RS04990	COG4106	trans-aconitate 2-methyltransferase activity
J5A60_RS04995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J5A60_RS05000	COG1074	ATP-dependent DNA helicase activity
J5A60_RS05010	COG2252	PERMEase
J5A60_RS05020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J5A60_RS05025	COG1067	ATP-dependent peptidase activity
J5A60_RS05035	COG1278	Cold shock
J5A60_RS05050	COG3098	single-species biofilm formation
J5A60_RS05055	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
J5A60_RS05065	COG3101	peptidyl-lysine hydroxylation
J5A60_RS05070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5A60_RS05080	COG0788	formyltetrahydrofolate deformylase activity
J5A60_RS05085	COG2916	Histone family protein nucleoid-structuring protein H-NS
J5A60_RS05090	COG1757	Na H antiporter
J5A60_RS05095	COG0028	Belongs to the TPP enzyme family
J5A60_RS05100	COG0440	acetolactate synthase activity
J5A60_RS05115	COG2949	membrane
J5A60_RS05120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J5A60_RS05130	COG3099	Belongs to the UPF0263 family
J5A60_RS05145	COG1840	ABC-type Fe3 transport system, periplasmic component
J5A60_RS05155	COG0732	type I restriction modification DNA specificity domain
J5A60_RS05175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5A60_RS05185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5A60_RS05190	COG0471	metal ion transport
J5A60_RS05195	COG0633	Ferredoxin
J5A60_RS05205	COG1280	lysine exporter protein (LysE YggA)
J5A60_RS05210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
J5A60_RS05215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J5A60_RS05225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J5A60_RS05240	COG0305	Participates in initiation and elongation during chromosome replication
J5A60_RS05245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J5A60_RS05250	COG4591	ABC-type transport system involved in lipoprotein release permease component
J5A60_RS05255	COG1136	(ABC) transporter
J5A60_RS05260	COG4591	ABC-type transport system involved in lipoprotein release permease component
J5A60_RS05265	COG1410	methionine synthase
J5A60_RS05265	COG0646	methionine synthase
J5A60_RS05280	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J5A60_RS05285	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J5A60_RS05300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5A60_RS05305	COG1621	beta-fructofuranosidase activity
J5A60_RS05310	COG0210	DNA helicase
J5A60_RS05315	COG2610	gluconate transmembrane transporter activity
J5A60_RS05320	COG3265	gluconokinase activity
J5A60_RS05325	COG1609	Transcriptional regulator
J5A60_RS05345	COG0437	4 iron, 4 sulfur cluster binding
J5A60_RS05350	COG2864	formate dehydrogenase
J5A60_RS05355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J5A60_RS05360	COG4149	molybdate abc transporter
J5A60_RS05365	COG0725	ABC transporter, periplasmic molybdate-binding protein
J5A60_RS05370	COG2005	Transcriptional regulator
J5A60_RS05380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5A60_RS05385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5A60_RS05385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5A60_RS05390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J5A60_RS05400	COG0583	DNA-binding transcription factor activity
J5A60_RS05405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5A60_RS05420	COG1090	epimerase
J5A60_RS05425	COG4657	Part of a membrane complex involved in electron transport
J5A60_RS05435	COG4656	Part of a membrane complex involved in electron transport
J5A60_RS05455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J5A60_RS05460	COG0733	neurotransmitter:sodium symporter activity
J5A60_RS05465	COG0488	(ABC) transporter
J5A60_RS05475	COG1346	cytolysis
J5A60_RS05490	COG1525	nuclease
J5A60_RS05495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J5A60_RS05500	COG2166	iron-sulfur cluster assembly
J5A60_RS05505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J5A60_RS05505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J5A60_RS05510	COG1560	Kdo2-lipid A biosynthetic process
J5A60_RS05515	COG3381	protein complex oligomerization
J5A60_RS05520	COG2249	NAD(P)H dehydrogenase (quinone) activity
J5A60_RS05530	COG0330	HflC and HflK could
J5A60_RS05575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J5A60_RS05580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J5A60_RS05585	COG2801	Transposase and inactivated derivatives
J5A60_RS05625	COG0024	Methionine aminopeptidase
J5A60_RS05630	COG0316	Belongs to the HesB IscA family
J5A60_RS05635	COG3112	Uncharacterised protein family (UPF0231)
J5A60_RS05640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5A60_RS05645	COG0277	FAD linked oxidase domain protein
J5A60_RS05650	COG1620	l-lactate permease
J5A60_RS05655	COG0247	lactate metabolic process
J5A60_RS05660	COG1139	Iron-sulfur cluster binding protein
J5A60_RS05665	COG1556	Lactate utilization protein
J5A60_RS05670	COG0672	)-iron permease
J5A60_RS05685	COG0577	efflux transmembrane transporter activity
J5A60_RS05695	COG1136	(ABC) transporter
J5A60_RS05695	COG0577	efflux transmembrane transporter activity
J5A60_RS05700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5A60_RS05740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J5A60_RS05740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J5A60_RS05750	COG2233	PERMEase
J5A60_RS05755	COG3069	C4-dicarboxylate transmembrane transporter activity
J5A60_RS05770	COG0825	malonyl-CoA metabolic process
J5A60_RS05785	COG2252	PERMEase
J5A60_RS05795	COG0375	protein maturation
J5A60_RS05800	COG2814	Major facilitator Superfamily
J5A60_RS05810	COG5295	Hep Hag repeat protein
J5A60_RS05810	COG5295	Hep Hag repeat protein
J5A60_RS05820	COG1643	Atp-dependent helicase
J5A60_RS05825	COG2363	Small membrane protein
J5A60_RS05840	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
J5A60_RS05850	COG1704	LemA family
J5A60_RS05855	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
J5A60_RS05855	COG2885	chlorophyll binding
J5A60_RS05860	COG0277	FAD linked oxidase domain protein
J5A60_RS05860	COG0247	lactate metabolic process
J5A60_RS05870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J5A60_RS05875	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J5A60_RS05880	COG0363	glucosamine-6-phosphate deaminase activity
J5A60_RS05885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5A60_RS05890	COG1737	Transcriptional regulator
J5A60_RS05900	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
J5A60_RS05905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J5A60_RS05910	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
J5A60_RS05910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
J5A60_RS05920	COG2190	(PTS) system
J5A60_RS05920	COG1263	PTS System
J5A60_RS05920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J5A60_RS05930	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
J5A60_RS05935	COG1178	ABC-type Fe3 transport system permease component
J5A60_RS05940	COG4143	(ABC) transporter
J5A60_RS05945	COG0351	phosphomethylpyrimidine kinase
J5A60_RS05960	COG0385	Bile acid
J5A60_RS05965	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J5A60_RS05980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5A60_RS05990	COG0642	Histidine kinase
J5A60_RS05995	COG0745	RESPONSE REGULATOR receiver
J5A60_RS06000	COG3111	PFAM Bacterial OB fold (BOF) protein
J5A60_RS06005	COG0436	Aminotransferase
J5A60_RS06015	COG0737	Belongs to the 5'-nucleotidase family
J5A60_RS06020	COG4607	ABC-type enterochelin transport system periplasmic component
J5A60_RS06025	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5A60_RS06030	COG4605	iron ion homeostasis
J5A60_RS06035	COG4604	ABC transporter, ATP-binding protein
J5A60_RS06040	COG0739	heme binding
J5A60_RS06050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5A60_RS06055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J5A60_RS06060	COG0795	lipopolysaccharide-transporting ATPase activity
J5A60_RS06065	COG0795	lipopolysaccharide-transporting ATPase activity
J5A60_RS06070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J5A60_RS06075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
J5A60_RS06080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J5A60_RS06095	COG0309	Hydrogenase expression formation protein (HypE)
J5A60_RS06100	COG0409	Hydrogenase expression formation protein
J5A60_RS06105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
J5A60_RS06110	COG1122	ATPase activity
J5A60_RS06115	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J5A60_RS06120	COG0310	cobalt ion transport
J5A60_RS06125	COG0310	cobalt ion transport
J5A60_RS06130	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
J5A60_RS06135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J5A60_RS06140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5A60_RS06145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J5A60_RS06150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5A60_RS06170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J5A60_RS06175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J5A60_RS06205	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J5A60_RS06215	COG0545	Peptidyl-prolyl cis-trans isomerase
J5A60_RS06220	COG0688	phosphatidylethanolamine metabolic process
J5A60_RS06225	COG0783	Belongs to the Dps family
J5A60_RS06230	COG1566	PFAM secretion protein HlyD family protein
J5A60_RS06235	COG2814	Major facilitator Superfamily
J5A60_RS06240	COG1840	ABC-type Fe3 transport system, periplasmic component
J5A60_RS06250	COG3550	peptidyl-serine autophosphorylation
J5A60_RS06270	COG2927	DNA polymerase III (CHI subunit)
J5A60_RS06275	COG0114	fumarate hydratase activity
J5A60_RS06280	COG2268	Band 7 protein
J5A60_RS06295	COG0778	Nitroreductase
J5A60_RS06300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J5A60_RS06305	COG0814	amino acid
J5A60_RS06325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J5A60_RS06335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J5A60_RS06380	COG1840	ABC-type Fe3 transport system, periplasmic component
J5A60_RS06385	COG1840	ABC-type Fe3 transport system, periplasmic component
J5A60_RS06395	COG3842	ATPase activity
J5A60_RS06405	COG0826	peptidase U32
J5A60_RS06415	COG0343	queuine tRNA-ribosyltransferase activity
J5A60_RS06420	COG3945	hemerythrin HHE cation binding domain
J5A60_RS06430	COG1862	Preprotein translocase
J5A60_RS06435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5A60_RS06440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5A60_RS06445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5A60_RS06450	COG0151	Belongs to the GarS family
J5A60_RS06455	COG0138	bifunctional purine biosynthesis protein purh
J5A60_RS06465	COG2813	Specifically methylates the guanine in position
J5A60_RS06470	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
J5A60_RS06475	COG0456	acetyltransferase
J5A60_RS06480	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J5A60_RS06495	COG4795	General secretion pathway protein
J5A60_RS06500	COG2165	general secretion pathway protein
J5A60_RS06530	COG3064	Membrane
J5A60_RS06535	COG0848	biopolymer transport protein
J5A60_RS06540	COG0811	peptide transport
J5A60_RS06545	COG0824	Thioesterase
J5A60_RS06555	COG1294	oxidase, subunit
J5A60_RS06560	COG1271	oxidase subunit
J5A60_RS06585	COG0641	radical SAM
J5A60_RS06595	COG0494	nUDIX hydrolase
J5A60_RS06605	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J5A60_RS06610	COG4106	trans-aconitate 2-methyltransferase activity
J5A60_RS06625	COG0346	lactoylglutathione lyase activity
J5A60_RS06635	COG2056	Na+-H+ antiporter family
J5A60_RS06650	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J5A60_RS06660	COG0142	geranyltranstransferase activity
J5A60_RS06675	COG0697	spore germination
J5A60_RS06680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J5A60_RS06690	COG0745	RESPONSE REGULATOR receiver
J5A60_RS06695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J5A60_RS06705	COG1611	Belongs to the LOG family
J5A60_RS06715	COG2259	Doxx family
J5A60_RS06720	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J5A60_RS06725	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
J5A60_RS06730	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J5A60_RS06735	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
J5A60_RS06745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J5A60_RS06755	COG5295	Hep Hag repeat protein
J5A60_RS06765	COG2860	membrane
J5A60_RS06775	COG0527	aspartate kinase activity
J5A60_RS06795	COG0626	cystathionine gamma-synthase activity
J5A60_RS06800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5A60_RS06810	COG0564	pseudouridine synthase activity
J5A60_RS06820	COG1530	ribonuclease E activity
J5A60_RS06830	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J5A60_RS06840	COG1444	tRNA N-acetyltransferase activity
J5A60_RS06845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J5A60_RS06850	COG1702	phosphate starvation-inducible protein PhoH
J5A60_RS06855	COG1181	Belongs to the D-alanine--D-alanine ligase family
J5A60_RS06855	COG2918	glutathione biosynthetic process
J5A60_RS06860	COG2194	sulfuric ester hydrolase activity
J5A60_RS06865	COG0740	serine-type endopeptidase activity
J5A60_RS06875	COG2217	Heavy metal translocating P-type atpase
J5A60_RS06880	COG2608	mercury ion transmembrane transporter activity
J5A60_RS06885	COG0789	Transcriptional regulator
J5A60_RS06890	COG1720	tRNA m6t6A37 methyltransferase activity
J5A60_RS06895	COG1575	Belongs to the MenA family. Type 1 subfamily
J5A60_RS06905	COG0471	metal ion transport
J5A60_RS06910	COG3028	Belongs to the UPF0307 family
J5A60_RS06915	COG0312	modulator of DNA gyrase
J5A60_RS06920	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J5A60_RS06925	COG0513	Belongs to the DEAD box helicase family
J5A60_RS06930	COG4785	May be involved in cell division
J5A60_RS06940	COG2731	YhcH YjgK YiaL family protein
J5A60_RS06945	COG2116	formate transmembrane transporter activity
J5A60_RS06955	COG3023	N-Acetylmuramoyl-L-alanine amidase
J5A60_RS06960	COG4969	Belongs to the N-Me-Phe pilin family
J5A60_RS06965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J5A60_RS06970	COG1459	type II secretion system
J5A60_RS06980	COG0237	dephospho-CoA kinase activity
J5A60_RS06980	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
J5A60_RS06995	COG1115	amino acid carrier protein
J5A60_RS07000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J5A60_RS07045	COG0592	DNA-directed DNA polymerase activity
J5A60_RS07055	COG2226	methyltransferase
J5A60_RS07080	COG0681	Belongs to the peptidase S26 family
J5A60_RS07095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J5A60_RS07110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J5A60_RS07135	COG0537	adenosine 5'-monophosphoramidase activity
J5A60_RS07140	COG2116	formate transmembrane transporter activity
J5A60_RS07145	COG1882	Formate acetyltransferase
J5A60_RS07150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J5A60_RS07155	COG0697	spore germination
J5A60_RS07165	COG0204	Acyl-transferase
J5A60_RS07175	COG5413	integral membrane protein
J5A60_RS07185	COG1509	lysine 2,3-aminomutase activity
J5A60_RS07190	COG3061	Opacity-associated protein A
J5A60_RS07190	COG3266	domain, Protein
J5A60_RS07200	COG1573	uracil-dna glycosylase
J5A60_RS07205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J5A60_RS07215	COG3115	cell septum assembly
J5A60_RS07235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J5A60_RS07240	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J5A60_RS07250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5A60_RS07260	COG1629	transport
J5A60_RS07260	COG4206	TonB-dependent receptor
J5A60_RS07265	COG1349	DNA-binding transcription factor activity
J5A60_RS07270	COG0705	Rhomboid family
J5A60_RS07280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5A60_RS07285	COG1555	photosystem II stabilization
J5A60_RS07290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J5A60_RS07300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J5A60_RS07305	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J5A60_RS07310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J5A60_RS07315	COG0800	Aldolase
J5A60_RS07320	COG0659	secondary active sulfate transmembrane transporter activity
J5A60_RS07330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J5A60_RS07335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J5A60_RS07345	COG2233	PERMEase
J5A60_RS07350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J5A60_RS07360	COG2976	Protein conserved in bacteria
J5A60_RS07375	COG1426	Protein conserved in bacteria
J5A60_RS07380	COG3063	Type IV pilus biogenesis stability protein PilW
J5A60_RS07390	COG3091	SprT-like family
J5A60_RS07410	COG1116	anion transmembrane transporter activity
J5A60_RS07415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5A60_RS07420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J5A60_RS07425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5A60_RS07435	COG0196	riboflavin kinase activity
J5A60_RS07440	COG0728	peptidoglycan biosynthetic process
J5A60_RS07455	COG0560	Phosphoserine phosphatase
J5A60_RS07465	COG0193	aminoacyl-tRNA hydrolase activity
J5A60_RS07470	COG0012	GTP binding
J5A60_RS07475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5A60_RS07485	COG0551	DNA topoisomerase type I activity
J5A60_RS07500	COG2962	Rard protein
J5A60_RS07505	COG0583	DNA-binding transcription factor activity
J5A60_RS07520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J5A60_RS07540	COG2183	response to ionizing radiation
J5A60_RS07545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J5A60_RS07550	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
J5A60_RS07555	COG1792	Involved in formation and maintenance of cell shape
J5A60_RS07560	COG1077	Cell shape determining protein MreB Mrl
J5A60_RS07565	COG0557	exoribonuclease II activity
J5A60_RS07575	COG2271	Major facilitator Superfamily
J5A60_RS07580	COG0584	glycerophosphoryl diester phosphodiesterase
J5A60_RS07605	COG0006	proline dipeptidase activity
J5A60_RS07625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J5A60_RS07640	COG1496	oxidoreductase activity
J5A60_RS07645	COG4771	TonB-dependent receptor
J5A60_RS07650	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J5A60_RS07655	COG3071	HemY protein
J5A60_RS07660	COG2959	enzyme of heme biosynthesis
J5A60_RS07670	COG0181	hydroxymethylbilane synthase activity
J5A60_RS07680	COG2197	response regulator
J5A60_RS07685	COG0729	surface antigen
J5A60_RS07690	COG2911	Protein conserved in bacteria
J5A60_RS07695	COG0248	Ppx GppA phosphatase
J5A60_RS07710	COG0482	sulfurtransferase activity
J5A60_RS07715	COG1942	4-Oxalocrotonate Tautomerase
J5A60_RS07720	COG2991	Protein conserved in bacteria
J5A60_RS07725	COG1477	protein flavinylation
J5A60_RS07740	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J5A60_RS07745	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J5A60_RS07760	COG0271	Belongs to the BolA IbaG family
J5A60_RS07765	COG3056	Lipoprotein
J5A60_RS07790	COG1194	a g-specific adenine glycosylase
J5A60_RS07800	COG3171	Protein conserved in bacteria
J5A60_RS07815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J5A60_RS07820	COG1840	ABC-type Fe3 transport system, periplasmic component
J5A60_RS07840	COG1178	ABC-type Fe3 transport system permease component
J5A60_RS07845	COG3842	ATPase activity
J5A60_RS07860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J5A60_RS07870	COG1561	YicC-like family, N-terminal region
J5A60_RS07875	COG0354	folic acid binding
J5A60_RS07885	COG2391	methyltransferase activity
J5A60_RS07890	COG0425	Belongs to the sulfur carrier protein TusA family
J5A60_RS07895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J5A60_RS07895	COG0475	glutathione-regulated potassium exporter activity
J5A60_RS07910	COG1381	Involved in DNA repair and RecF pathway recombination
J5A60_RS07915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J5A60_RS07920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J5A60_RS07925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J5A60_RS07930	COG0789	Transcriptional regulator
J5A60_RS07935	COG1230	cation diffusion facilitator family transporter
J5A60_RS07940	COG2177	Part of the ABC transporter FtsEX involved in
J5A60_RS07945	COG2884	Cell division ATP-binding protein ftsE
J5A60_RS07950	COG0552	protein localization to endoplasmic reticulum
J5A60_RS07955	COG0742	ribosomal rna small subunit methyltransferase
J5A60_RS07970	COG1393	Belongs to the ArsC family
J5A60_RS07980	COG3036	rescue of stalled ribosome
J5A60_RS07985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5A60_RS07990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5A60_RS07995	COG2841	Protein conserved in bacteria
J5A60_RS08010	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
J5A60_RS08020	COG0569	domain protein
J5A60_RS08025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J5A60_RS08025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J5A60_RS08060	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
J5A60_RS08065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J5A60_RS08070	COG1739	Uncharacterized protein family UPF0029
J5A60_RS08080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J5A60_RS08085	COG3172	ATPase kinase involved in NAD metabolism
J5A60_RS08090	COG2129	metallophosphoesterase
J5A60_RS08095	COG0814	amino acid
J5A60_RS08100	COG0789	Transcriptional regulator
J5A60_RS08105	COG4701	Protein of unknown function (DUF721)
J5A60_RS08120	COG0494	nUDIX hydrolase
J5A60_RS08130	COG1466	dna polymerase III delta subunit
J5A60_RS08135	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
J5A60_RS08150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J5A60_RS08155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J5A60_RS08160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J5A60_RS08170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J5A60_RS08175	COG1555	photosystem II stabilization
J5A60_RS08175	COG1596	polysaccharide export
J5A60_RS08195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J5A60_RS08205	COG1040	competence protein
J5A60_RS08215	COG1114	Component of the transport system for branched-chain amino acids
J5A60_RS08245	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J5A60_RS08255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J5A60_RS08265	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
J5A60_RS08275	COG0589	response to stress
J5A60_RS08280	COG3956	TIGRFAM MazG family protein
J5A60_RS08285	COG0402	S-adenosylhomocysteine deaminase activity
J5A60_RS08290	COG3083	sulfuric ester hydrolase activity
J5A60_RS08295	COG3082	Protein of unknown function (DUF1414)
J5A60_RS08305	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J5A60_RS08310	COG0745	RESPONSE REGULATOR receiver
J5A60_RS08315	COG0786	glutamate:sodium symporter activity
J5A60_RS08320	COG1490	D-aminoacyl-tRNA deacylase activity
J5A60_RS08330	COG3012	SEC-C Motif Domain Protein
J5A60_RS08335	COG2258	MOSC domain
J5A60_RS08340	COG0433	COG0433 Predicted ATPase
J5A60_RS08345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J5A60_RS08350	COG1349	DNA-binding transcription factor activity
J5A60_RS08360	COG3068	Protein conserved in bacteria
J5A60_RS08365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J5A60_RS08390	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J5A60_RS08410	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J5A60_RS08425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J5A60_RS08425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J5A60_RS08425	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
J5A60_RS08430	COG1105	Belongs to the carbohydrate kinase PfkB family
J5A60_RS08435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5A60_RS08435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5A60_RS08445	COG0746	molybdenum cofactor guanylyltransferase activity
J5A60_RS08450	COG3084	Protein conserved in bacteria
J5A60_RS08455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5A60_RS08460	COG3085	chromosome segregation
J5A60_RS08475	COG0754	glutathionylspermidine amidase activity
J5A60_RS08490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J5A60_RS08500	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
J5A60_RS08505	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J5A60_RS08510	COG2818	Glycosylase
J5A60_RS08520	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J5A60_RS08525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J5A60_RS08540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5A60_RS08545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5A60_RS08550	COG0765	amino acid transport
J5A60_RS08555	COG1126	abc transporter atp-binding protein
J5A60_RS08560	COG2168	tRNA wobble position uridine thiolation
J5A60_RS08570	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
J5A60_RS08575	COG2964	Protein conserved in bacteria
J5A60_RS08580	COG0545	Peptidyl-prolyl cis-trans isomerase
J5A60_RS08585	COG2900	Belongs to the SlyX family
J5A60_RS08590	COG0678	peroxiredoxin activity
J5A60_RS08590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J5A60_RS08595	COG0583	DNA-binding transcription factor activity
J5A60_RS08600	COG1309	transcriptional regulator
J5A60_RS08605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5A60_RS08615	COG0859	PFAM glycosyl transferase family 9
J5A60_RS08620	COG0754	glutathionylspermidine amidase activity
J5A60_RS08625	COG3005	denitrification pathway
J5A60_RS08630	COG3043	anaerobic respiration
J5A60_RS08635	COG0348	domain, Protein
J5A60_RS08640	COG0437	4 iron, 4 sulfur cluster binding
J5A60_RS08645	COG0243	molybdopterin cofactor binding
J5A60_RS08650	COG3062	negative regulation of establishment of protein localization
J5A60_RS08655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J5A60_RS08660	COG3850	Histidine kinase
J5A60_RS08665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J5A60_RS08675	COG1275	C4-dicarboxylate transporter malic acid transport protein
J5A60_RS08680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5A60_RS08685	COG2195	Cleaves the N-terminal amino acid of tripeptides
J5A60_RS08720	COG1072	(Pantothenic acid kinase))
J5A60_RS08725	COG0187	DNA topoisomerase II activity
J5A60_RS08730	COG0514	ATP-dependent DNA helicase (RecQ)
J5A60_RS08735	COG1965	Belongs to the frataxin family
J5A60_RS08740	COG0019	diaminopimelate decarboxylase activity
J5A60_RS08745	COG0251	oxidation-reduction process
J5A60_RS08755	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J5A60_RS08760	COG0488	(ABC) transporter
J5A60_RS08765	COG2095	MarC family integral membrane protein
J5A60_RS08795	COG2801	Transposase and inactivated derivatives
J5A60_RS08800	COG2842	Transposition protein
J5A60_RS08815	COG4396	Host-nuclease inhibitor protein Gam
J5A60_RS08845	COG4382	Mu-like prophage protein Gp16
J5A60_RS08865	COG3023	N-Acetylmuramoyl-L-alanine amidase
J5A60_RS08895	COG0640	Transcriptional regulator
J5A60_RS08920	COG5005	Phage virion morphogenesis
J5A60_RS09040	COG4416	COG NOG18757 non supervised orthologous group
J5A60_RS09045	COG3392	D12 class N6 adenine-specific DNA methyltransferase
J5A60_RS09085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5A60_RS09095	COG0765	amino acid transport
J5A60_RS09100	COG0765	amino acid transport
J5A60_RS09105	COG3071	HemY protein
J5A60_RS09120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J5A60_RS09150	COG1238	metal cluster binding
J5A60_RS09160	COG1388	LysM domain
J5A60_RS09160	COG4942	peptidase
J5A60_RS09195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J5A60_RS09200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J5A60_RS09230	COG3312	ion transport
J5A60_RS09240	COG0445	tRNA wobble uridine modification
J5A60_RS09260	COG0629	single-stranded DNA binding
J5A60_RS09270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J5A60_RS09310	COG3177	Filamentation induced by cAMP protein fic
J5A60_RS09390	COG0629	single-stranded DNA binding
J5A60_RS09435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J5A60_RS09440	COG3177	Filamentation induced by cAMP protein fic
J5A60_RS09530	COG3321	synthase
J5A60_RS09530	COG0604	alcohol dehydrogenase
J5A60_RS09540	COG3210	domain, Protein