locus-tag	class	description
AGREI_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AGREI_RS00010	COG0592	DNA-directed DNA polymerase activity
AGREI_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AGREI_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AGREI_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AGREI_RS00030	COG0187	DNA topoisomerase II activity
AGREI_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AGREI_RS00040	COG3266	domain, Protein
AGREI_RS00070	COG0705	Rhomboid family
AGREI_RS00070	COG0457	Tetratricopeptide repeat
AGREI_RS00080	COG3764	Sortase (surface protein transpeptidase)
AGREI_RS00095	COG2815	serine threonine protein kinase
AGREI_RS00095	COG0515	serine threonine protein kinase
AGREI_RS00100	COG0515	serine threonine protein kinase
AGREI_RS00105	COG0768	penicillin binding
AGREI_RS00120	COG1716	ATPase activity
AGREI_RS00145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AGREI_RS00150	COG0393	Putative heavy-metal-binding
AGREI_RS00170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AGREI_RS00205	COG2814	Major facilitator Superfamily
AGREI_RS00215	COG2226	methyltransferase
AGREI_RS00230	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AGREI_RS00235	COG0738	Major facilitator superfamily
AGREI_RS00240	COG1609	Transcriptional regulator
AGREI_RS00290	COG0534	Mate efflux family protein
AGREI_RS00295	COG3590	peptidase
AGREI_RS00300	COG1609	Transcriptional regulator
AGREI_RS00315	COG0395	ABC-type sugar transport system, permease component
AGREI_RS00345	COG1597	lipid kinase activity
AGREI_RS00350	COG0583	DNA-binding transcription factor activity
AGREI_RS00380	COG0515	serine threonine protein kinase
AGREI_RS00400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AGREI_RS00405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AGREI_RS00415	COG0454	-acetyltransferase
AGREI_RS00440	COG3253	May function as heme-dependent peroxidase
AGREI_RS00445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AGREI_RS00450	COG0181	hydroxymethylbilane synthase activity
AGREI_RS00460	COG0113	porphobilinogen synthase activity
AGREI_RS00465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AGREI_RS00470	COG1302	Protein conserved in bacteria
AGREI_RS00475	COG1595	DNA-templated transcription, initiation
AGREI_RS00495	COG1902	pentaerythritol trinitrate reductase activity
AGREI_RS00530	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AGREI_RS00535	COG1054	Belongs to the UPF0176 family
AGREI_RS00545	COG1045	serine acetyltransferase
AGREI_RS00550	COG3458	cephalosporin-C deacetylase activity
AGREI_RS00555	COG0483	inositol monophosphate 1-phosphatase activity
AGREI_RS00560	COG3842	ATPase activity
AGREI_RS00565	COG3833	ABC-type maltose transport systems, permease component
AGREI_RS00580	COG1609	Transcriptional regulator
AGREI_RS00585	COG1174	glycine betaine transport
AGREI_RS00595	COG1174	glycine betaine transport
AGREI_RS00620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AGREI_RS00625	COG1024	Enoyl-CoA hydratase
AGREI_RS00670	COG3387	PFAM Glycoside hydrolase 15-related
AGREI_RS00685	COG2814	Major facilitator Superfamily
AGREI_RS00690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AGREI_RS00710	COG3718	enzyme involved in inositol metabolism
AGREI_RS00715	COG3962	Belongs to the TPP enzyme family
AGREI_RS00730	COG1082	Xylose isomerase domain protein TIM barrel
AGREI_RS00735	COG1942	4-Oxalocrotonate Tautomerase
AGREI_RS00740	COG2188	Transcriptional regulator
AGREI_RS00745	COG1607	acyl-coa hydrolase
AGREI_RS00780	COG0586	Pfam SNARE associated Golgi protein
AGREI_RS00785	COG3012	SEC-C Motif Domain Protein
AGREI_RS00875	COG2197	response regulator
AGREI_RS00880	COG4585	Histidine kinase
AGREI_RS00885	COG0842	Transport permease protein
AGREI_RS00890	COG1131	(ABC) transporter
AGREI_RS00910	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AGREI_RS00910	COG2755	lipolytic protein G-D-S-L family
AGREI_RS00920	COG1012	belongs to the aldehyde dehydrogenase family
AGREI_RS00930	COG2130	NADP-dependent
AGREI_RS00940	COG0659	secondary active sulfate transmembrane transporter activity
AGREI_RS00975	COG4221	oxidoreductase activity
AGREI_RS00990	COG1609	Transcriptional regulator
AGREI_RS01015	COG1653	transport
AGREI_RS01020	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AGREI_RS01040	COG2354	Protein conserved in bacteria
AGREI_RS01045	COG2326	polyphosphate kinase activity
AGREI_RS01050	COG1725	Transcriptional regulator
AGREI_RS01055	COG2357	RelA SpoT domain protein
AGREI_RS01065	COG1834	amidinotransferase
AGREI_RS01070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AGREI_RS01130	COG2814	Major facilitator Superfamily
AGREI_RS01135	COG2130	NADP-dependent
AGREI_RS01145	COG0277	FAD linked oxidase domain protein
AGREI_RS01150	COG0673	inositol 2-dehydrogenase activity
AGREI_RS01175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AGREI_RS01180	COG4585	Histidine kinase
AGREI_RS01185	COG2197	response regulator
AGREI_RS01210	COG1305	Transglutaminase-like
AGREI_RS01230	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AGREI_RS01260	COG1876	peptidase activity
AGREI_RS01280	COG0077	Prephenate dehydratase
AGREI_RS01290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AGREI_RS01295	COG0561	phosphatase activity
AGREI_RS01315	COG0277	FAD linked oxidase domain protein
AGREI_RS01320	COG1940	carbohydrate kinase activity
AGREI_RS01325	COG1879	ABC-type sugar transport system periplasmic component
AGREI_RS01330	COG1172	Belongs to the binding-protein-dependent transport system permease family
AGREI_RS01350	COG1072	(Pantothenic acid kinase))
AGREI_RS01380	COG0363	glucosamine-6-phosphate deaminase activity
AGREI_RS01385	COG0673	inositol 2-dehydrogenase activity
AGREI_RS01390	COG0673	inositol 2-dehydrogenase activity
AGREI_RS01400	COG1940	carbohydrate kinase activity
AGREI_RS01415	COG1175	transmembrane transport
AGREI_RS01490	COG0415	Belongs to the DNA photolyase family
AGREI_RS01520	COG1609	Transcriptional regulator
AGREI_RS01530	COG0640	Transcriptional regulator
AGREI_RS01535	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_RS01540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_RS01545	COG4607	ABC-type enterochelin transport system periplasmic component
AGREI_RS01555	COG2308	Evidence 4 Homologs of previously reported genes of
AGREI_RS01555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AGREI_RS01560	COG0745	RESPONSE REGULATOR receiver
AGREI_RS01565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AGREI_RS01570	COG0590	tRNA wobble adenosine to inosine editing
AGREI_RS01580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AGREI_RS01595	COG0569	domain protein
AGREI_RS01600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AGREI_RS01605	COG0640	Transcriptional regulator
AGREI_RS01615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AGREI_RS01640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AGREI_RS01655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AGREI_RS01660	COG0785	Cytochrome C biogenesis protein
AGREI_RS01680	COG2267	carboxylic ester hydrolase activity
AGREI_RS01715	COG0573	inorganic phosphate transmembrane transporter activity
AGREI_RS01735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AGREI_RS01750	COG2815	serine threonine protein kinase
AGREI_RS01750	COG0515	serine threonine protein kinase
AGREI_RS01765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AGREI_RS01770	COG4948	Mandelate Racemase Muconate Lactonizing
AGREI_RS01775	COG0328	RNA-DNA hybrid ribonuclease activity
AGREI_RS01785	COG1846	Transcriptional regulator
AGREI_RS01790	COG1764	response to oxidative stress
AGREI_RS01830	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AGREI_RS01845	COG0596	Alpha beta hydrolase
AGREI_RS01850	COG2326	polyphosphate kinase activity
AGREI_RS01860	COG1169	isochorismate synthase
AGREI_RS01865	COG2226	methyltransferase
AGREI_RS01870	COG0142	geranyltranstransferase activity
AGREI_RS01885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_RS01890	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_RS01895	COG1120	ATPase activity
AGREI_RS01905	COG0494	nUDIX hydrolase
AGREI_RS01910	COG1666	GTP binding
AGREI_RS01930	COG0739	heme binding
AGREI_RS01930	COG0741	lytic transglycosylase activity
AGREI_RS01930	COG1196	nuclear chromosome segregation
AGREI_RS01935	COG0366	Alpha amylase catalytic
AGREI_RS01955	COG0745	RESPONSE REGULATOR receiver
AGREI_RS01965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AGREI_RS01975	COG2030	dehydratase
AGREI_RS01985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AGREI_RS02030	COG1329	Transcriptional regulator
AGREI_RS02065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AGREI_RS02140	COG1131	(ABC) transporter
AGREI_RS02175	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AGREI_RS02180	COG1090	epimerase
AGREI_RS02230	COG1609	Transcriptional regulator
AGREI_RS02235	COG1874	Beta-galactosidase
AGREI_RS02245	COG1175	transmembrane transport
AGREI_RS02250	COG0395	ABC-type sugar transport system, permease component
AGREI_RS02285	COG1609	Transcriptional regulator
AGREI_RS02290	COG1653	transport
AGREI_RS02295	COG1175	transmembrane transport
AGREI_RS02300	COG0395	ABC-type sugar transport system, permease component
AGREI_RS02305	COG1472	Belongs to the glycosyl hydrolase 3 family
AGREI_RS02375	COG0489	protein tyrosine kinase activity
AGREI_RS02375	COG3206	protein involved in exopolysaccharide biosynthesis
AGREI_RS02380	COG0297	glycogen (starch) synthase activity
AGREI_RS02395	COG3420	alginic acid biosynthetic process
AGREI_RS02410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AGREI_RS02430	COG2755	lipolytic protein G-D-S-L family
AGREI_RS02435	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AGREI_RS02440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AGREI_RS02525	COG0489	protein tyrosine kinase activity
AGREI_RS02530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AGREI_RS02535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AGREI_RS02560	COG0297	glycogen (starch) synthase activity
AGREI_RS02565	COG0438	transferase activity, transferring glycosyl groups
AGREI_RS02600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AGREI_RS02605	COG1846	Transcriptional regulator
AGREI_RS02615	COG1316	TRANSCRIPTIONal
AGREI_RS02635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AGREI_RS02655	COG1609	Transcriptional regulator
AGREI_RS02660	COG4213	ABC transporter substrate-binding protein
AGREI_RS02665	COG1129	ABC transporter
AGREI_RS02670	COG4214	carbohydrate transport
AGREI_RS02675	COG1129	ABC transporter
AGREI_RS02685	COG0588	phosphoglycerate mutase activity
AGREI_RS02705	COG0436	Aminotransferase
AGREI_RS02730	COG1088	dTDP-glucose 4,6-dehydratase activity
AGREI_RS02750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AGREI_RS02755	COG0081	regulation of translation
AGREI_RS02765	COG0477	Major facilitator Superfamily
AGREI_RS02770	COG1309	transcriptional regulator
AGREI_RS02790	COG0604	alcohol dehydrogenase
AGREI_RS02790	COG3321	synthase
AGREI_RS02790	COG4221	oxidoreductase activity
AGREI_RS02790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AGREI_RS02810	COG1136	(ABC) transporter
AGREI_RS02820	COG0745	RESPONSE REGULATOR receiver
AGREI_RS02825	COG2205	protein histidine kinase activity
AGREI_RS02830	COG1301	dicarboxylic acid transport
AGREI_RS02835	COG0823	Involved in the tonB-independent uptake of proteins
AGREI_RS02845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AGREI_RS02850	COG0222	ribosome binding
AGREI_RS02860	COG1609	Transcriptional regulator
AGREI_RS02865	COG1653	transport
AGREI_RS02870	COG1175	transmembrane transport
AGREI_RS02875	COG0395	ABC-type sugar transport system, permease component
AGREI_RS02880	COG1132	(ABC) transporter
AGREI_RS02900	COG0686	Belongs to the AlaDH PNT family
AGREI_RS02910	COG1506	peptidase
AGREI_RS02910	COG4946	Tricorn protease homolog
AGREI_RS02910	COG0823	Involved in the tonB-independent uptake of proteins
AGREI_RS02920	COG1780	Probably involved in ribonucleotide reductase function
AGREI_RS02925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AGREI_RS02930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AGREI_RS02935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AGREI_RS02945	COG0477	Major facilitator Superfamily
AGREI_RS02950	COG1733	regulation of RNA biosynthetic process
AGREI_RS02955	COG0702	epimerase
AGREI_RS02960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AGREI_RS02965	COG0318	PFAM AMP-dependent synthetase and ligase
AGREI_RS02970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AGREI_RS02975	COG0406	alpha-ribazole phosphatase activity
AGREI_RS02985	COG1464	Belongs to the NlpA lipoprotein family
AGREI_RS02990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AGREI_RS02995	COG2011	ABC-type metal ion transport system permease component
AGREI_RS03005	COG0765	amino acid transport
AGREI_RS03010	COG1126	abc transporter atp-binding protein
AGREI_RS03015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AGREI_RS03025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_RS03030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_RS03065	COG1609	Transcriptional regulator
AGREI_RS03080	COG2160	L-arabinose isomerase activity
AGREI_RS03095	COG1129	ABC transporter
AGREI_RS03100	COG4214	carbohydrate transport
AGREI_RS03110	COG1070	Carbohydrate kinase
AGREI_RS03115	COG2115	Belongs to the xylose isomerase family
AGREI_RS03120	COG4213	ABC transporter substrate-binding protein
AGREI_RS03125	COG1129	ABC transporter
AGREI_RS03130	COG4214	carbohydrate transport
AGREI_RS03135	COG1940	carbohydrate kinase activity
AGREI_RS03140	COG1846	Transcriptional regulator
AGREI_RS03140	COG1940	carbohydrate kinase activity
AGREI_RS03145	COG2814	Major facilitator Superfamily
AGREI_RS03170	COG0395	ABC-type sugar transport system, permease component
AGREI_RS03175	COG3534	alpha-L-arabinofuranosidase
AGREI_RS03185	COG4948	Mandelate Racemase Muconate Lactonizing
AGREI_RS03190	COG0433	COG0433 Predicted ATPase
AGREI_RS03205	COG0667	Aldo Keto reductase
AGREI_RS03210	COG2815	serine threonine protein kinase
AGREI_RS03210	COG0515	serine threonine protein kinase
AGREI_RS03245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AGREI_RS03265	COG1971	Probably functions as a manganese efflux pump
AGREI_RS03275	COG4221	oxidoreductase activity
AGREI_RS03305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AGREI_RS03310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AGREI_RS03335	COG0702	epimerase
AGREI_RS03370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AGREI_RS03380	COG0456	acetyltransferase
AGREI_RS03390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AGREI_RS03435	COG0579	oxidoreductase
AGREI_RS03470	COG1435	thymidine kinase activity
AGREI_RS03490	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AGREI_RS03505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AGREI_RS03540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AGREI_RS03540	COG1754	DNA topoisomerase type I activity
AGREI_RS03545	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AGREI_RS03550	COG0470	DNA polymerase III
AGREI_RS03580	COG1335	isochorismatase
AGREI_RS03585	COG2409	Drug exporters of the RND superfamily
AGREI_RS03595	COG1132	(ABC) transporter
AGREI_RS03600	COG0477	Major facilitator Superfamily
AGREI_RS03605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AGREI_RS03610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AGREI_RS03615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AGREI_RS03615	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AGREI_RS03630	COG1216	Glycosyl transferase, family 2
AGREI_RS03645	COG0180	Tryptophanyl-tRNA synthetase
AGREI_RS03660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AGREI_RS03665	COG1053	succinate dehydrogenase
AGREI_RS03675	COG2009	succinate dehydrogenase
AGREI_RS03680	COG0438	transferase activity, transferring glycosyl groups
AGREI_RS03690	COG1744	ABC transporter substrate-binding protein PnrA-like
AGREI_RS03700	COG3845	ABC transporter
AGREI_RS03705	COG4603	Belongs to the binding-protein-dependent transport system permease family
AGREI_RS03710	COG1079	Belongs to the binding-protein-dependent transport system permease family
AGREI_RS03745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AGREI_RS03760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AGREI_RS03775	COG4770	biotin carboxylase activity
AGREI_RS03780	COG0424	maF-like protein
AGREI_RS03785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AGREI_RS03810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AGREI_RS03830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AGREI_RS03835	COG1316	TRANSCRIPTIONal
AGREI_RS03890	COG1216	Glycosyl transferase, family 2
AGREI_RS04000	COG1960	acyl-CoA dehydrogenase activity
AGREI_RS04005	COG1482	cell wall glycoprotein biosynthetic process
AGREI_RS04015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AGREI_RS04045	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AGREI_RS04070	COG0714	Associated with various cellular activities
AGREI_RS04090	COG0745	RESPONSE REGULATOR receiver
AGREI_RS04095	COG5000	phosphorelay sensor kinase activity
AGREI_RS04095	COG5002	protein histidine kinase activity
AGREI_RS04105	COG1040	competence protein
AGREI_RS04110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AGREI_RS04115	COG0653	protein targeting
AGREI_RS04180	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AGREI_RS04185	COG3387	PFAM Glycoside hydrolase 15-related
AGREI_RS04190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AGREI_RS04210	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AGREI_RS04215	COG1012	belongs to the aldehyde dehydrogenase family
AGREI_RS04220	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_RS04225	COG2188	Transcriptional regulator
AGREI_RS04235	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AGREI_RS04245	COG0129	dihydroxy-acid dehydratase activity
AGREI_RS04250	COG0028	Belongs to the TPP enzyme family
AGREI_RS04255	COG0440	acetolactate synthase activity
AGREI_RS04260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AGREI_RS04300	COG0477	Major facilitator Superfamily
AGREI_RS04315	COG0473	3-isopropylmalate dehydrogenase activity
AGREI_RS04320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AGREI_RS04330	COG0179	Fumarylacetoacetate (FAA) hydrolase
AGREI_RS04335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AGREI_RS04340	COG0492	ferredoxin-NADP+ reductase activity
AGREI_RS04355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AGREI_RS04380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AGREI_RS04455	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AGREI_RS04460	COG0066	3-isopropylmalate dehydratase activity
AGREI_RS04465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AGREI_RS04480	COG1181	Belongs to the D-alanine--D-alanine ligase family
AGREI_RS04485	COG1716	ATPase activity
AGREI_RS04495	COG0631	protein serine/threonine phosphatase activity
AGREI_RS04510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AGREI_RS04520	COG0464	growth
AGREI_RS04535	COG0598	Magnesium transport protein CorA
AGREI_RS04550	COG0742	ribosomal rna small subunit methyltransferase
AGREI_RS04555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AGREI_RS04560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AGREI_RS04580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AGREI_RS04615	COG0456	acetyltransferase
AGREI_RS04640	COG0477	Major facilitator Superfamily
AGREI_RS04675	COG0488	(ABC) transporter
AGREI_RS04680	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AGREI_RS04685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_RS04690	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AGREI_RS04690	COG0778	Nitroreductase
AGREI_RS04695	COG1920	GTP binding
AGREI_RS04710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AGREI_RS04735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AGREI_RS04745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AGREI_RS04755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AGREI_RS04770	COG0583	DNA-binding transcription factor activity
AGREI_RS04780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AGREI_RS04785	COG0571	ribonuclease III activity
AGREI_RS04790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AGREI_RS04805	COG3619	membrane
AGREI_RS04820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AGREI_RS04900	COG0402	S-adenosylhomocysteine deaminase activity
AGREI_RS04910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AGREI_RS04925	COG0259	pyridoxamine-phosphate oxidase activity
AGREI_RS04945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AGREI_RS04955	COG0402	S-adenosylhomocysteine deaminase activity
AGREI_RS04975	COG0402	S-adenosylhomocysteine deaminase activity
AGREI_RS04980	COG1335	isochorismatase
AGREI_RS05005	COG0402	S-adenosylhomocysteine deaminase activity
AGREI_RS05010	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AGREI_RS05010	COG3608	succinylglutamate desuccinylase aspartoacylase
AGREI_RS05030	COG0314	molybdopterin synthase activity
AGREI_RS05035	COG0521	Mo-molybdopterin cofactor biosynthetic process
AGREI_RS05080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AGREI_RS05085	COG2318	DinB family
AGREI_RS05100	COG4251	negative regulation of phosphorylation
AGREI_RS05105	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AGREI_RS05110	COG1196	nuclear chromosome segregation
AGREI_RS05115	COG0321	lipoyl(octanoyl) transferase activity
AGREI_RS05120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AGREI_RS05130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_RS05135	COG2814	Major facilitator Superfamily
AGREI_RS05160	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AGREI_RS05165	COG0228	four-way junction DNA binding
AGREI_RS05170	COG1837	Belongs to the UPF0109 family
AGREI_RS05175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AGREI_RS05190	COG0336	Belongs to the RNA methyltransferase TrmD family
AGREI_RS05205	COG0335	large ribosomal subunit rRNA binding
AGREI_RS05215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AGREI_RS05235	COG0792	nuclease activity
AGREI_RS05250	COG0702	epimerase
AGREI_RS05270	COG0395	ABC-type sugar transport system, permease component
AGREI_RS05285	COG4974	Belongs to the 'phage' integrase family
AGREI_RS05295	COG0477	Major facilitator Superfamily
AGREI_RS05305	COG0052	Belongs to the universal ribosomal protein uS2 family
AGREI_RS05310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AGREI_RS05320	COG0528	UMP kinase activity
AGREI_RS05325	COG0233	cytoplasmic translational termination
AGREI_RS05375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AGREI_RS05380	COG0366	Alpha amylase catalytic
AGREI_RS05385	COG0058	SHG alpha-glucan phosphorylase activity
AGREI_RS05415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AGREI_RS05425	COG0482	sulfurtransferase activity
AGREI_RS05430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AGREI_RS05435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AGREI_RS05440	COG0154	amidase activity
AGREI_RS05445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AGREI_RS05465	COG0318	PFAM AMP-dependent synthetase and ligase
AGREI_RS05475	COG1755	Isoprenylcysteine carboxyl methyltransferase
AGREI_RS05490	COG0667	Aldo Keto reductase
AGREI_RS05500	COG0706	membrane insertase activity
AGREI_RS05510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AGREI_RS05540	COG4721	ABC-type cobalt transport system, permease component
AGREI_RS05545	COG1122	ATPase activity
AGREI_RS05580	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AGREI_RS05610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AGREI_RS05610	COG1017	nitric oxide dioxygenase activity
AGREI_RS05625	COG0667	Aldo Keto reductase
AGREI_RS05650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AGREI_RS05655	COG1946	Acyl-CoA thioesterase
AGREI_RS05670	COG0668	transmembrane transport
AGREI_RS05690	COG2808	Putative FMN-binding domain
AGREI_RS05695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AGREI_RS05705	COG2326	polyphosphate kinase activity
AGREI_RS05710	COG0783	Belongs to the Dps family
AGREI_RS05730	COG0544	peptidyl-prolyl cis-trans isomerase activity
AGREI_RS05750	COG2733	membrane
AGREI_RS05755	COG0740	serine-type endopeptidase activity
AGREI_RS05760	COG0740	serine-type endopeptidase activity
AGREI_RS05765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AGREI_RS05770	COG3135	benzoate transporter
AGREI_RS05795	COG0525	valine-tRNA ligase activity
AGREI_RS05800	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AGREI_RS05815	COG0747	negative chemotaxis
AGREI_RS05820	COG0601	transmembrane transport
AGREI_RS05825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AGREI_RS05845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AGREI_RS05850	COG0285	dihydrofolate synthase activity
AGREI_RS05860	COG0105	UTP biosynthetic process
AGREI_RS05870	COG1530	ribonuclease E activity
AGREI_RS05880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AGREI_RS05885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AGREI_RS05890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AGREI_RS05895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AGREI_RS05900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AGREI_RS05910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AGREI_RS05920	COG0799	negative regulation of ribosome biogenesis
AGREI_RS05930	COG1309	transcriptional regulator
AGREI_RS05935	COG0477	Major facilitator Superfamily
AGREI_RS05960	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AGREI_RS05965	COG2353	YceI-like domain
AGREI_RS05970	COG2267	carboxylic ester hydrolase activity
AGREI_RS05980	COG0587	DNA-directed DNA polymerase activity
AGREI_RS05995	COG2197	response regulator
AGREI_RS06015	COG0517	IMP dehydrogenase activity
AGREI_RS06015	COG1125	glycine betaine transport
AGREI_RS06020	COG1174	glycine betaine transport
AGREI_RS06025	COG1174	glycine betaine transport
AGREI_RS06035	COG0586	Pfam SNARE associated Golgi protein
AGREI_RS06050	COG1271	oxidase subunit
AGREI_RS06055	COG1294	oxidase, subunit
AGREI_RS06060	COG4988	ABC transporter
AGREI_RS06065	COG1132	(ABC) transporter
AGREI_RS06080	COG0519	Catalyzes the synthesis of GMP from XMP
AGREI_RS06085	COG0495	leucyl-tRNA aminoacylation
AGREI_RS06090	COG1555	photosystem II stabilization
AGREI_RS06090	COG1596	polysaccharide export
AGREI_RS06105	COG0268	Binds directly to 16S ribosomal RNA
AGREI_RS06120	COG0481	GTPase activity
AGREI_RS06145	COG1420	regulation of RNA biosynthetic process
AGREI_RS06150	COG0484	heat shock protein binding
AGREI_RS06160	COG0537	adenosine 5'-monophosphoramidase activity
AGREI_RS06170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AGREI_RS06180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AGREI_RS06185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AGREI_RS06190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AGREI_RS06200	COG1674	ftsk spoiiie
AGREI_RS06210	COG1546	Belongs to the CinA family
AGREI_RS06210	COG1058	Belongs to the CinA family
AGREI_RS06215	COG1396	sequence-specific DNA binding
AGREI_RS06225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AGREI_RS06235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AGREI_RS06240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AGREI_RS06245	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AGREI_RS06250	COG2813	Specifically methylates the guanine in position
AGREI_RS06255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AGREI_RS06260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AGREI_RS06270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AGREI_RS06275	COG0131	Imidazoleglycerol-phosphate dehydratase
AGREI_RS06280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AGREI_RS06285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AGREI_RS06300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AGREI_RS06305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AGREI_RS06310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AGREI_RS06315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AGREI_RS06320	COG1126	abc transporter atp-binding protein
AGREI_RS06325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AGREI_RS06330	COG0765	amino acid transport
AGREI_RS06335	COG0765	amino acid transport
AGREI_RS06340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AGREI_RS06345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AGREI_RS06345	COG0072	phenylalanine-tRNA ligase activity
AGREI_RS06350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AGREI_RS06355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AGREI_RS06360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AGREI_RS06370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AGREI_RS06375	COG0165	Argininosuccinate lyase
AGREI_RS06385	COG2094	Belongs to the DNA glycosylase MPG family
AGREI_RS06400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AGREI_RS06425	COG0647	UMP catabolic process
AGREI_RS06440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AGREI_RS06445	COG0497	DNA recombination
AGREI_RS06450	COG0504	CTP synthase activity
AGREI_RS06455	COG0494	nUDIX hydrolase
AGREI_RS06470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AGREI_RS06475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AGREI_RS06490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AGREI_RS06495	COG1160	GTP binding
AGREI_RS06535	COG1175	transmembrane transport
AGREI_RS06550	COG0248	Ppx GppA phosphatase
AGREI_RS06565	COG1695	Transcriptional regulator
AGREI_RS06570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AGREI_RS06585	COG1064	alcohol dehydrogenase
AGREI_RS06595	COG2315	Protein conserved in bacteria
AGREI_RS06605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_RS06630	COG1793	dna ligase
AGREI_RS06645	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AGREI_RS06680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AGREI_RS06710	COG1716	ATPase activity
AGREI_RS06725	COG1192	Involved in chromosome partitioning
AGREI_RS06730	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AGREI_RS06760	COG1940	carbohydrate kinase activity
AGREI_RS06765	COG0204	Acyl-transferase
AGREI_RS06770	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AGREI_RS06775	COG0515	serine threonine protein kinase
AGREI_RS06775	COG2815	serine threonine protein kinase
AGREI_RS06780	COG1134	teichoic acid transport
AGREI_RS06780	COG1388	LysM domain
AGREI_RS06790	COG0142	geranyltranstransferase activity
AGREI_RS06800	COG2001	Belongs to the MraZ family
AGREI_RS06805	COG0275	rRNA processing
AGREI_RS06815	COG0768	penicillin binding
AGREI_RS06820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AGREI_RS06830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AGREI_RS06835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AGREI_RS06845	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AGREI_RS06850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AGREI_RS06860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AGREI_RS06870	COG1799	cell septum assembly
AGREI_RS06880	COG3599	regulation of cell shape
AGREI_RS06885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AGREI_RS06895	COG0587	DNA-directed DNA polymerase activity
AGREI_RS06905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AGREI_RS06910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AGREI_RS06915	COG0167	dihydroorotate dehydrogenase activity
AGREI_RS06940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AGREI_RS06945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AGREI_RS06955	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AGREI_RS06960	COG0723	plastoquinol--plastocyanin reductase activity
AGREI_RS06965	COG2010	Cytochrome c
AGREI_RS06970	COG1845	cytochrome c oxidase, subunit III
AGREI_RS06975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AGREI_RS06980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AGREI_RS06985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AGREI_RS06990	COG2376	Dihydroxyacetone kinase
AGREI_RS06995	COG1461	Dihydroxyacetone kinase
AGREI_RS07000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AGREI_RS07000	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AGREI_RS07000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AGREI_RS07005	COG1051	belongs to the nudix hydrolase family
AGREI_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_RS07025	COG0584	glycerophosphoryl diester phosphodiesterase
AGREI_RS07045	COG0805	protein transport
AGREI_RS07050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AGREI_RS07080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AGREI_RS07090	COG0215	cysteine-tRNA ligase activity
AGREI_RS07095	COG1968	undecaprenyl-diphosphatase activity
AGREI_RS07100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AGREI_RS07110	COG1278	Cold shock
AGREI_RS07150	COG0406	alpha-ribazole phosphatase activity
AGREI_RS07165	COG0366	Alpha amylase catalytic
AGREI_RS07175	COG0254	rRNA binding
AGREI_RS07180	COG1119	ATPase activity
AGREI_RS07185	COG0297	glycogen (starch) synthase activity
AGREI_RS07190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AGREI_RS07195	COG0560	Phosphoserine phosphatase
AGREI_RS07200	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_RS07220	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AGREI_RS07225	COG1122	ATPase activity
AGREI_RS07230	COG0183	Belongs to the thiolase family
AGREI_RS07240	COG1268	BioY protein
AGREI_RS07250	COG0488	(ABC) transporter
AGREI_RS07255	COG2151	metal-sulfur cluster biosynthetic enzyme
AGREI_RS07260	COG0396	ATPase activity
AGREI_RS07265	COG2146	nitrite reductase [NAD(P)H] activity
AGREI_RS07280	COG1612	heme a metabolic process
AGREI_RS07285	COG0109	protoheme IX farnesyltransferase activity
AGREI_RS07290	COG4702	Belongs to the UPF0303 family
AGREI_RS07300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AGREI_RS07315	COG0363	glucosamine-6-phosphate deaminase activity
AGREI_RS07325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AGREI_RS07330	COG0149	triose-phosphate isomerase activity
AGREI_RS07335	COG0126	phosphoglycerate kinase activity
AGREI_RS07340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AGREI_RS07345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AGREI_RS07350	COG1481	regulation of sporulation
AGREI_RS07355	COG1660	Displays ATPase and GTPase activities
AGREI_RS07360	COG0322	excinuclease ABC activity
AGREI_RS07370	COG0556	nucleotide-excision repair
AGREI_RS07380	COG0237	dephospho-CoA kinase activity
AGREI_RS07405	COG2050	protein possibly involved in aromatic compounds catabolism
AGREI_RS07435	COG0469	pyruvate kinase activity
AGREI_RS07445	COG0070	glutamate synthase
AGREI_RS07445	COG0069	glutamate synthase activity
AGREI_RS07445	COG0067	glutamate synthase
AGREI_RS07450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AGREI_RS07455	COG0159	tryptophan synthase activity
AGREI_RS07460	COG0133	tryptophan synthase activity
AGREI_RS07465	COG0134	indole-3-glycerol-phosphate synthase activity
AGREI_RS07485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AGREI_RS07490	COG0107	imidazoleglycerol-phosphate synthase activity
AGREI_RS07495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AGREI_RS07500	COG0140	phosphoribosyl-ATP diphosphatase activity
AGREI_RS07515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AGREI_RS07525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AGREI_RS07535	COG1758	RNA polymerase activity
AGREI_RS07540	COG0194	GDP metabolic process
AGREI_RS07545	COG0284	orotidine-5'-phosphate decarboxylase activity
AGREI_RS07550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AGREI_RS07555	COG0505	Belongs to the CarA family
AGREI_RS07565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AGREI_RS07570	COG0540	Belongs to the ATCase OTCase family
AGREI_RS07575	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AGREI_RS07580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AGREI_RS07585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AGREI_RS07590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AGREI_RS07600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AGREI_RS07605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AGREI_RS07610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AGREI_RS07615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AGREI_RS07625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AGREI_RS07630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AGREI_RS07650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AGREI_RS07665	COG1196	nuclear chromosome segregation
AGREI_RS07675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AGREI_RS07680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AGREI_RS07685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AGREI_RS07695	COG2255	four-way junction helicase activity
AGREI_RS07700	COG0632	four-way junction helicase activity
AGREI_RS07705	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AGREI_RS07710	COG0217	transcriptional regulatory protein
AGREI_RS07715	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AGREI_RS07720	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AGREI_RS07730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AGREI_RS07755	COG1864	DNA RNA non-specific endonuclease
AGREI_RS07755	COG3591	Belongs to the peptidase S1B family
AGREI_RS07765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_RS07780	COG3387	PFAM Glycoside hydrolase 15-related
AGREI_RS07785	COG0783	Belongs to the Dps family
AGREI_RS07825	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AGREI_RS07830	COG0183	Belongs to the thiolase family
AGREI_RS07835	COG1024	Enoyl-CoA hydratase
AGREI_RS07835	COG1250	3-hydroxyacyl-CoA dehydrogenase
AGREI_RS07840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AGREI_RS07845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AGREI_RS07860	COG0756	dUTP diphosphatase activity
AGREI_RS07885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AGREI_RS07895	COG0187	DNA topoisomerase II activity
AGREI_RS07900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AGREI_RS07905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AGREI_RS07920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AGREI_RS07935	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AGREI_RS07940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AGREI_RS07945	COG0508	dehydrogenase complex catalyzes the overall conversion of
AGREI_RS07950	COG0515	serine threonine protein kinase
AGREI_RS07950	COG2815	serine threonine protein kinase
AGREI_RS07965	COG0174	glutamine synthetase
AGREI_RS07975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AGREI_RS07980	COG0174	glutamine synthetase
AGREI_RS07990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AGREI_RS08015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AGREI_RS08040	COG4974	Belongs to the 'phage' integrase family
AGREI_RS08070	COG5297	Belongs to the glycosyl hydrolase family 6
AGREI_RS08290	COG0450	alkyl hydroperoxide reductase
AGREI_RS08295	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AGREI_RS08310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AGREI_RS08315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AGREI_RS08320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AGREI_RS08345	COG0714	Associated with various cellular activities
AGREI_RS08360	COG0438	transferase activity, transferring glycosyl groups
AGREI_RS08370	COG0242	peptide deformylase activity
AGREI_RS08405	COG0601	transmembrane transport
AGREI_RS08435	COG0442	prolyl-tRNA aminoacylation
AGREI_RS08445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AGREI_RS08450	COG1381	Involved in DNA repair and RecF pathway recombination
AGREI_RS08455	COG2860	membrane
AGREI_RS08460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AGREI_RS08475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AGREI_RS08490	COG0612	Peptidase, M16
AGREI_RS08495	COG1185	polyribonucleotide nucleotidyltransferase activity
AGREI_RS08525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AGREI_RS08545	COG0545	Peptidyl-prolyl cis-trans isomerase
AGREI_RS08560	COG0277	FAD linked oxidase domain protein
AGREI_RS08575	COG3281	Trehalose synthase
AGREI_RS08590	COG0438	transferase activity, transferring glycosyl groups
AGREI_RS08595	COG0598	Magnesium transport protein CorA
AGREI_RS08600	COG0435	Glutathione S-transferase
AGREI_RS08605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AGREI_RS08615	COG1090	epimerase
AGREI_RS08640	COG0702	epimerase
AGREI_RS08655	COG0196	riboflavin kinase activity
AGREI_RS08670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AGREI_RS08700	COG1194	a g-specific adenine glycosylase
AGREI_RS08705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AGREI_RS08710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AGREI_RS08725	COG0195	Participates in both transcription termination and antitermination
AGREI_RS08730	COG0442	prolyl-tRNA aminoacylation
AGREI_RS08735	COG1316	TRANSCRIPTIONal
AGREI_RS08765	COG0714	Associated with various cellular activities
AGREI_RS08770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AGREI_RS08775	COG2197	response regulator
AGREI_RS08780	COG4585	Histidine kinase
AGREI_RS08785	COG0750	zinc metalloprotease
AGREI_RS08790	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AGREI_RS08815	COG2091	lysine biosynthetic process via aminoadipic acid
AGREI_RS08825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AGREI_RS08845	COG0631	protein serine/threonine phosphatase activity
AGREI_RS08860	COG0519	Catalyzes the synthesis of GMP from XMP
AGREI_RS08870	COG3022	response to hydroperoxide
AGREI_RS08875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AGREI_RS08880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AGREI_RS08885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AGREI_RS08890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AGREI_RS08895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AGREI_RS08900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AGREI_RS08905	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AGREI_RS08910	COG0356	it plays a direct role in the translocation of protons across the membrane
AGREI_RS08920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AGREI_RS08935	COG2890	protein-(glutamine-N5) methyltransferase activity
AGREI_RS08940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AGREI_RS08950	COG0083	homoserine kinase activity
AGREI_RS08960	COG0460	homoserine dehydrogenase
AGREI_RS08980	COG0018	arginyl-trna synthetase
AGREI_RS08985	COG1305	Transglutaminase-like
AGREI_RS08995	COG0028	Belongs to the TPP enzyme family
AGREI_RS09025	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AGREI_RS09035	COG1842	Phage shock protein A
AGREI_RS09040	COG0010	Belongs to the arginase family
AGREI_RS09045	COG1024	Enoyl-CoA hydratase
AGREI_RS09075	COG4552	Acetyltransferase involved in intracellular survival and related
AGREI_RS09095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AGREI_RS09105	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AGREI_RS09125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AGREI_RS09185	COG0567	Dehydrogenase, E1 component
AGREI_RS09185	COG0508	dehydrogenase complex catalyzes the overall conversion of
AGREI_RS09195	COG1595	DNA-templated transcription, initiation
AGREI_RS09200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AGREI_RS09210	COG0483	inositol monophosphate 1-phosphatase activity
AGREI_RS09215	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AGREI_RS09235	COG0438	transferase activity, transferring glycosyl groups
AGREI_RS09240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AGREI_RS09260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AGREI_RS09265	COG2177	Part of the ABC transporter FtsEX involved in
AGREI_RS09270	COG2884	Cell division ATP-binding protein ftsE
AGREI_RS09275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AGREI_RS09285	COG0477	Major facilitator Superfamily
AGREI_RS09330	COG1136	(ABC) transporter
AGREI_RS09335	COG4585	Histidine kinase
AGREI_RS09340	COG2197	response regulator
AGREI_RS09350	COG0586	Pfam SNARE associated Golgi protein
AGREI_RS09365	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AGREI_RS09370	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AGREI_RS09375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AGREI_RS09380	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AGREI_RS09425	COG2807	transmembrane transport
AGREI_RS09435	COG2890	protein-(glutamine-N5) methyltransferase activity
AGREI_RS09445	COG0667	Aldo Keto reductase
AGREI_RS09455	COG0477	Major facilitator Superfamily
AGREI_RS09460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_RS09465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AGREI_RS09510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AGREI_RS09535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AGREI_RS09540	COG1846	Transcriptional regulator
AGREI_RS09540	COG1940	carbohydrate kinase activity
AGREI_RS09550	COG1653	transport
AGREI_RS09555	COG1175	transmembrane transport
AGREI_RS09560	COG0395	ABC-type sugar transport system, permease component
AGREI_RS09565	COG0366	Alpha amylase catalytic
AGREI_RS09570	COG2079	MmgE PrpD family protein
AGREI_RS09575	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AGREI_RS09580	COG1309	transcriptional regulator
AGREI_RS09590	COG2017	converts alpha-aldose to the beta-anomer
AGREI_RS09595	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AGREI_RS09600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AGREI_RS09605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AGREI_RS09620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AGREI_RS09650	COG0395	ABC-type sugar transport system, permease component
AGREI_RS09665	COG1609	Transcriptional regulator
AGREI_RS09675	COG1615	UPF0182 protein
AGREI_RS09680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AGREI_RS09740	COG0513	Belongs to the DEAD box helicase family
AGREI_RS09750	COG0006	proline dipeptidase activity
AGREI_RS09760	COG2239	Acts as a magnesium transporter
AGREI_RS09780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AGREI_RS09815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AGREI_RS09835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AGREI_RS09840	COG2171	N-acyltransferase activity
AGREI_RS09845	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AGREI_RS09870	COG0672	)-iron permease
AGREI_RS09875	COG2822	iron ion transport
AGREI_RS09880	COG2837	iron assimilation
AGREI_RS09885	COG1217	gtp-binding protein TYPA
AGREI_RS09895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AGREI_RS09900	COG0601	transmembrane transport
AGREI_RS09905	COG4166	transmembrane transport
AGREI_RS09925	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AGREI_RS09925	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AGREI_RS09930	COG0509	glycine decarboxylation via glycine cleavage system
AGREI_RS09935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AGREI_RS09955	COG0488	(ABC) transporter
AGREI_RS09960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AGREI_RS09965	COG2267	carboxylic ester hydrolase activity
AGREI_RS09970	COG0012	GTP binding
AGREI_RS09985	COG1322	Protein conserved in bacteria
AGREI_RS09995	COG0191	fructose-bisphosphate aldolase activity
AGREI_RS10005	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AGREI_RS10010	COG1570	exodeoxyribonuclease VII activity
AGREI_RS10015	COG1722	exodeoxyribonuclease VII activity
AGREI_RS10030	COG0114	fumarate hydratase activity
AGREI_RS10040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AGREI_RS10045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AGREI_RS10070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AGREI_RS10080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AGREI_RS10090	COG3842	ATPase activity
AGREI_RS10110	COG3214	Protein conserved in bacteria
AGREI_RS10115	COG0501	Belongs to the peptidase M48B family
AGREI_RS10120	COG1704	LemA family
AGREI_RS10145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AGREI_RS10150	COG0514	ATP-dependent DNA helicase (RecQ)
AGREI_RS10155	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AGREI_RS10175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AGREI_RS10180	COG2409	Drug exporters of the RND superfamily
AGREI_RS10225	COG0148	phosphopyruvate hydratase activity
AGREI_RS10240	COG0124	histidyl-tRNA synthetase
AGREI_RS10260	COG0193	aminoacyl-tRNA hydrolase activity
AGREI_RS10265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AGREI_RS10280	COG0583	DNA-binding transcription factor activity
AGREI_RS10285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AGREI_RS10290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AGREI_RS10305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AGREI_RS10310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AGREI_RS10330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AGREI_RS10335	COG1309	transcriptional regulator
AGREI_RS10340	COG3321	synthase
AGREI_RS10340	COG0604	alcohol dehydrogenase
AGREI_RS10345	COG3409	Peptidoglycan-binding domain 1 protein
AGREI_RS10365	COG0137	argininosuccinate synthase activity
AGREI_RS10370	COG0488	(ABC) transporter
AGREI_RS10375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AGREI_RS10380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AGREI_RS10390	COG1131	(ABC) transporter
AGREI_RS10395	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AGREI_RS10405	COG1079	Belongs to the binding-protein-dependent transport system permease family
AGREI_RS10410	COG4603	Belongs to the binding-protein-dependent transport system permease family
AGREI_RS10415	COG3845	ABC transporter
AGREI_RS10420	COG1744	ABC transporter substrate-binding protein PnrA-like
AGREI_RS10425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AGREI_RS10430	COG0084	hydrolase, TatD family'
AGREI_RS10435	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AGREI_RS10455	COG2855	membrane
AGREI_RS10470	COG1132	(ABC) transporter
AGREI_RS10495	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AGREI_RS10500	COG1760	l-serine dehydratase
AGREI_RS10515	COG1349	DNA-binding transcription factor activity
AGREI_RS10525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AGREI_RS10530	COG1331	Highly conserved protein containing a thioredoxin domain
AGREI_RS10540	COG2986	histidine ammonia-lyase
AGREI_RS10575	COG1011	Hydrolase
AGREI_RS10585	COG1643	Atp-dependent helicase
AGREI_RS10600	COG2723	6-phospho-beta-galactosidase activity
AGREI_RS10605	COG0596	Alpha beta hydrolase
AGREI_RS10620	COG0601	transmembrane transport
AGREI_RS10625	COG4166	transmembrane transport
AGREI_RS10655	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AGREI_RS10685	COG0318	PFAM AMP-dependent synthetase and ligase
AGREI_RS10720	COG0587	DNA-directed DNA polymerase activity
AGREI_RS10725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AGREI_RS10740	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AGREI_RS10815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_RS10825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AGREI_RS10835	COG3237	CsbD-like
AGREI_RS10850	COG1126	abc transporter atp-binding protein
AGREI_RS10855	COG0765	amino acid transport
AGREI_RS10860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AGREI_RS10865	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AGREI_RS10870	COG2072	flavoprotein involved in K transport
AGREI_RS10880	COG0438	transferase activity, transferring glycosyl groups
AGREI_RS10885	COG3537	Alpha-1,2-mannosidase
AGREI_RS10895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_RS10900	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_RS10905	COG1120	ATPase activity
AGREI_RS10930	COG3639	organic phosphonate transmembrane transporter activity
AGREI_RS10940	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AGREI_RS10965	COG2815	serine threonine protein kinase
AGREI_RS10965	COG0515	serine threonine protein kinase
AGREI_RS11005	COG1321	iron dependent repressor
AGREI_RS11010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AGREI_RS11020	COG1278	Cold shock
AGREI_RS11045	COG0745	RESPONSE REGULATOR receiver
AGREI_RS11050	COG2205	protein histidine kinase activity
AGREI_RS11060	COG0459	protein refolding
AGREI_RS11085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AGREI_RS11095	COG2814	Major facilitator Superfamily
AGREI_RS11110	COG3842	ATPase activity
AGREI_RS11120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AGREI_RS11125	COG0215	cysteine-tRNA ligase activity
AGREI_RS11130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AGREI_RS11130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AGREI_RS11135	COG1329	Transcriptional regulator
AGREI_RS11150	COG5002	protein histidine kinase activity
AGREI_RS11160	COG0588	phosphoglycerate mutase activity
AGREI_RS11175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AGREI_RS11180	COG3485	protocatechuate 3,4-dioxygenase
AGREI_RS11190	COG0745	RESPONSE REGULATOR receiver
AGREI_RS11195	COG0456	acetyltransferase
AGREI_RS11200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AGREI_RS11225	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AGREI_RS11295	COG2017	converts alpha-aldose to the beta-anomer
AGREI_RS11300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AGREI_RS11305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AGREI_RS11330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AGREI_RS11355	COG1132	(ABC) transporter
AGREI_RS11360	COG1132	(ABC) transporter
AGREI_RS11365	COG1834	amidinotransferase
AGREI_RS11370	COG0138	bifunctional purine biosynthesis protein purh
AGREI_RS11395	COG0045	succinate-CoA ligase (ADP-forming) activity
AGREI_RS11420	COG0584	glycerophosphoryl diester phosphodiesterase
AGREI_RS11435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AGREI_RS11435	COG0519	Catalyzes the synthesis of GMP from XMP
AGREI_RS11450	COG0475	glutathione-regulated potassium exporter activity
AGREI_RS11460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AGREI_RS11465	COG0516	GMP reductase activity
AGREI_RS11505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AGREI_RS11525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AGREI_RS11530	COG0456	acetyltransferase
AGREI_RS11540	COG0802	atpase or kinase
AGREI_RS11545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AGREI_RS11550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AGREI_RS11555	COG0736	holo-[acyl-carrier-protein] synthase activity
AGREI_RS11560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AGREI_RS11565	COG1072	(Pantothenic acid kinase))
AGREI_RS11570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AGREI_RS11575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AGREI_RS11580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AGREI_RS11585	COG0101	tRNA pseudouridine synthase activity
AGREI_RS11590	COG0203	ribosomal protein L17
AGREI_RS11595	COG0202	RNA polymerase activity
AGREI_RS11600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AGREI_RS11605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AGREI_RS11610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AGREI_RS11615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AGREI_RS11620	COG0246	Mannitol dehydrogenase
AGREI_RS11625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AGREI_RS11630	COG2213	PTS system mannitol-specific
AGREI_RS11635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AGREI_RS11650	COG3711	transcriptional antiterminator
AGREI_RS11660	COG0563	adenylate kinase activity
AGREI_RS11670	COG0200	Binds to the 23S rRNA
AGREI_RS11675	COG1841	ribosomal large subunit assembly
AGREI_RS11680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AGREI_RS11685	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AGREI_RS11690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AGREI_RS11695	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AGREI_RS11700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AGREI_RS11705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AGREI_RS11710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AGREI_RS11715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AGREI_RS11725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AGREI_RS11730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AGREI_RS11735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AGREI_RS11740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AGREI_RS11745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AGREI_RS11750	COG0089	rRNA binding
AGREI_RS11755	COG0088	Forms part of the polypeptide exit tunnel
AGREI_RS11760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AGREI_RS11765	COG0051	transcription antitermination factor activity, RNA binding
AGREI_RS11785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AGREI_RS11790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AGREI_RS11795	COG0049	tRNA binding
AGREI_RS11800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AGREI_RS11825	COG0714	Associated with various cellular activities
AGREI_RS11865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AGREI_RS11870	COG0085	RNA polymerase activity
AGREI_RS11940	COG1201	RNA secondary structure unwinding
AGREI_RS11945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AGREI_RS11950	COG1937	Protein conserved in bacteria
AGREI_RS11960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AGREI_RS11970	COG0583	DNA-binding transcription factor activity
AGREI_RS12010	COG5006	permease, DMT superfamily
AGREI_RS12015	COG0277	FAD linked oxidase domain protein
AGREI_RS12025	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_RS12065	COG0395	ABC-type sugar transport system, permease component
AGREI_RS12070	COG1175	transmembrane transport
AGREI_RS12095	COG1609	Transcriptional regulator
AGREI_RS12100	COG1621	beta-fructofuranosidase activity
AGREI_RS12120	COG1609	Transcriptional regulator
AGREI_RS12125	COG0252	asparaginase activity
AGREI_RS12275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AGREI_RS12325	COG0446	pyridine nucleotide-disulphide oxidoreductase
AGREI_RS12335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AGREI_RS12350	COG0640	Transcriptional regulator
AGREI_RS12375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AGREI_RS12400	COG1196	nuclear chromosome segregation
AGREI_RS12400	COG0741	lytic transglycosylase activity
AGREI_RS12400	COG0739	heme binding
AGREI_RS12445	COG0785	Cytochrome C biogenesis protein
AGREI_RS12450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AGREI_RS12475	COG4974	Belongs to the 'phage' integrase family
AGREI_RS12500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AGREI_RS12505	COG2272	Belongs to the type-B carboxylesterase lipase family
AGREI_RS12545	COG1051	belongs to the nudix hydrolase family
AGREI_RS12550	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AGREI_RS12570	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_RS12595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AGREI_RS12610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AGREI_RS12625	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AGREI_RS12650	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AGREI_RS12660	COG0302	gtp cyclohydrolase
AGREI_RS12665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AGREI_RS12675	COG0037	tRNA processing
AGREI_RS12680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AGREI_RS12685	COG0739	heme binding
AGREI_RS12705	COG0588	phosphoglycerate mutase activity
AGREI_RS12770	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AGREI_RS12780	COG1129	ABC transporter
AGREI_RS12785	COG4214	carbohydrate transport
AGREI_RS12805	COG0235	Class ii aldolase
AGREI_RS12810	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AGREI_RS12815	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AGREI_RS12820	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AGREI_RS12835	COG2197	response regulator
AGREI_RS12840	COG4585	Histidine kinase
AGREI_RS12850	COG1131	(ABC) transporter
AGREI_RS12865	COG0204	Acyl-transferase
AGREI_RS12865	COG0318	PFAM AMP-dependent synthetase and ligase
AGREI_RS12870	COG0514	ATP-dependent DNA helicase (RecQ)
AGREI_RS12900	COG0513	Belongs to the DEAD box helicase family
AGREI_RS12905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AGREI_RS12915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AGREI_RS12925	COG0423	glycine-tRNA ligase activity
AGREI_RS12935	COG0531	amino acid
AGREI_RS12950	COG2890	protein-(glutamine-N5) methyltransferase activity
AGREI_RS12975	COG0151	Belongs to the GarS family
AGREI_RS12980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AGREI_RS12990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AGREI_RS13000	COG2850	peptidyl-arginine hydroxylation
AGREI_RS13025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_RS13030	COG1120	ATPase activity
AGREI_RS13040	COG2514	catechol 2,3-dioxygenase activity
AGREI_RS13045	COG0318	PFAM AMP-dependent synthetase and ligase
AGREI_RS13050	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AGREI_RS13055	COG0047	phosphoribosylformylglycinamidine synthase activity
AGREI_RS13060	COG0822	iron-sulfur transferase activity
AGREI_RS13070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AGREI_RS13095	COG1605	Chorismate mutase
AGREI_RS13095	COG0287	Prephenate dehydrogenase
AGREI_RS13100	COG1764	response to oxidative stress
AGREI_RS13110	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AGREI_RS13145	COG0326	Molecular chaperone. Has ATPase activity
AGREI_RS13155	COG5002	protein histidine kinase activity
AGREI_RS13180	COG0745	RESPONSE REGULATOR receiver
AGREI_RS13190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AGREI_RS13225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AGREI_RS13290	COG2814	Major facilitator Superfamily
AGREI_RS13295	COG2814	Major facilitator Superfamily
AGREI_RS13310	COG0546	phosphoglycolate phosphatase activity
AGREI_RS13340	COG0542	response to heat
AGREI_RS13345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AGREI_RS13395	COG2813	Specifically methylates the guanine in position
AGREI_RS13400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AGREI_RS13410	COG1335	isochorismatase
AGREI_RS13425	COG0789	Transcriptional regulator
AGREI_RS13430	COG0484	heat shock protein binding
AGREI_RS13435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AGREI_RS13440	COG0443	Heat shock 70 kDa protein
AGREI_RS13485	COG0142	geranyltranstransferase activity
AGREI_RS13490	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AGREI_RS13495	COG2111	Na H antiporter
AGREI_RS13495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AGREI_RS13500	COG1006	Multisubunit Na H antiporter MnhC subunit
AGREI_RS13505	COG0651	ATP synthesis coupled electron transport
AGREI_RS13515	COG2212	antiporter activity
AGREI_RS13520	COG1320	monovalent cation:proton antiporter activity
AGREI_RS13525	COG0717	Belongs to the dCTP deaminase family
AGREI_RS13535	COG2261	transglycosylase associated protein
AGREI_RS13540	COG2197	response regulator
AGREI_RS13545	COG3527	Alpha-acetolactate decarboxylase
AGREI_RS13575	COG0395	ABC-type sugar transport system, permease component
AGREI_RS13620	COG2271	Major facilitator Superfamily
AGREI_RS13635	COG4565	transcriptional regulatory protein
AGREI_RS13640	COG3290	protein histidine kinase activity
AGREI_RS13645	COG1301	dicarboxylic acid transport
AGREI_RS13650	COG4608	Belongs to the ABC transporter superfamily
AGREI_RS13655	COG0444	Belongs to the ABC transporter superfamily
AGREI_RS13660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AGREI_RS13665	COG0601	transmembrane transport
AGREI_RS13670	COG0747	negative chemotaxis
AGREI_RS13685	COG0006	proline dipeptidase activity
AGREI_RS13700	COG1012	belongs to the aldehyde dehydrogenase family
AGREI_RS13705	COG1362	aminopeptidase activity
AGREI_RS13715	COG2267	carboxylic ester hydrolase activity
AGREI_RS13720	COG0531	amino acid
AGREI_RS13740	COG1846	Transcriptional regulator
AGREI_RS13765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AGREI_RS13765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AGREI_RS13765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AGREI_RS13770	COG1105	Belongs to the carbohydrate kinase PfkB family
AGREI_RS13775	COG1349	DNA-binding transcription factor activity
AGREI_RS13780	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AGREI_RS13785	COG0671	phosphoesterase, PA-phosphatase related
AGREI_RS13790	COG0386	Belongs to the glutathione peroxidase family
AGREI_RS13805	COG1309	transcriptional regulator
AGREI_RS13820	COG0667	Aldo Keto reductase
AGREI_RS13835	COG2226	methyltransferase
AGREI_RS13835	COG1073	alpha beta
AGREI_RS13865	COG0419	ATPase involved in DNA repair
AGREI_RS13870	COG0420	3'-5' exonuclease activity
AGREI_RS13880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AGREI_RS13885	COG0686	Belongs to the AlaDH PNT family
AGREI_RS13915	COG2217	Heavy metal translocating P-type atpase
AGREI_RS13935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AGREI_RS13950	COG2233	PERMEase
AGREI_RS13965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AGREI_RS13965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AGREI_RS13970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AGREI_RS13980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AGREI_RS13985	COG1120	ATPase activity
AGREI_RS13990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_RS14030	COG1063	alcohol dehydrogenase
AGREI_RS14040	COG2367	Beta-lactamase
AGREI_RS14050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AGREI_RS14060	COG1349	DNA-binding transcription factor activity
AGREI_RS14070	COG1175	transmembrane transport
AGREI_RS14075	COG0395	ABC-type sugar transport system, permease component
AGREI_RS14095	COG1309	transcriptional regulator
AGREI_RS14100	COG2076	Multidrug Resistance protein
AGREI_RS14110	COG1929	Belongs to the glycerate kinase type-1 family
AGREI_RS14115	COG2814	Major facilitator Superfamily
AGREI_RS14120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AGREI_RS14175	COG3142	Participates in the control of copper homeostasis
AGREI_RS14185	COG0765	amino acid transport
AGREI_RS14190	COG0765	amino acid transport
AGREI_RS14200	COG1126	abc transporter atp-binding protein
AGREI_RS14205	COG1940	carbohydrate kinase activity
AGREI_RS14215	COG2084	Dehydrogenase
AGREI_RS14225	COG1172	Belongs to the binding-protein-dependent transport system permease family
AGREI_RS14235	COG1879	ABC-type sugar transport system periplasmic component
AGREI_RS14245	COG1609	Transcriptional regulator
AGREI_RS14255	COG3265	gluconokinase activity
AGREI_RS14260	COG1234	tRNA 3'-trailer cleavage
AGREI_RS14265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AGREI_RS14275	COG4149	molybdate abc transporter
AGREI_RS14285	COG1609	Transcriptional regulator
AGREI_RS14300	COG2851	Citrate transporter
AGREI_RS14305	COG3290	protein histidine kinase activity
AGREI_RS14310	COG4565	transcriptional regulatory protein
AGREI_RS14360	COG0657	acetylesterase activity
AGREI_RS14430	COG1309	transcriptional regulator
AGREI_RS14435	COG4221	oxidoreductase activity
AGREI_RS14495	COG2072	flavoprotein involved in K transport
AGREI_RS14505	COG0657	acetylesterase activity
AGREI_RS14530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AGREI_RS14560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AGREI_RS14565	COG0805	protein transport
AGREI_RS14570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AGREI_RS14575	COG4251	negative regulation of phosphorylation
AGREI_RS14645	COG1349	DNA-binding transcription factor activity
AGREI_RS14660	COG1192	Involved in chromosome partitioning
AGREI_RS14670	COG3046	protein related to deoxyribodipyrimidine photolyase
AGREI_RS14770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AGREI_RS14790	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AGREI_RS14790	COG2755	lipolytic protein G-D-S-L family
AGREI_RS14805	COG2197	response regulator
AGREI_RS14820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AGREI_RS14875	COG0166	Belongs to the GPI family
AGREI_RS14880	COG0659	secondary active sulfate transmembrane transporter activity
AGREI_RS14895	COG0765	amino acid transport
AGREI_RS14900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AGREI_RS14925	COG1228	amidohydrolase
AGREI_RS14930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AGREI_RS14935	COG0180	Tryptophanyl-tRNA synthetase
AGREI_RS14950	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AGREI_RS14955	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AGREI_RS14960	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AGREI_RS15000	COG0673	inositol 2-dehydrogenase activity
AGREI_RS15030	COG1072	(Pantothenic acid kinase))
AGREI_RS15060	COG5398	heme oxygenase
AGREI_RS15070	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AGREI_RS15075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AGREI_RS15085	COG1104	cysteine desulfurase activity
AGREI_RS15090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AGREI_RS15100	COG3336	cytochrome c oxidase
AGREI_RS15105	COG0776	regulation of translation
AGREI_RS15110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AGREI_RS15115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AGREI_RS15120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AGREI_RS15160	COG2267	carboxylic ester hydrolase activity
AGREI_RS15250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AGREI_RS15265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AGREI_RS15275	COG1476	TRANSCRIPTIONal
AGREI_RS15285	COG2197	response regulator
AGREI_RS15290	COG4585	Histidine kinase
AGREI_RS15300	COG1131	(ABC) transporter
AGREI_RS15325	COG2205	protein histidine kinase activity
AGREI_RS15330	COG0745	RESPONSE REGULATOR receiver
AGREI_RS15355	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AGREI_RS15365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AGREI_RS15365	COG0352	thiamine-phosphate diphosphorylase activity
AGREI_RS15365	COG0351	phosphomethylpyrimidine kinase
AGREI_RS15400	COG1609	Transcriptional regulator
AGREI_RS15440	COG2197	response regulator
AGREI_RS15445	COG4585	Histidine kinase
AGREI_RS15485	COG0508	dehydrogenase complex catalyzes the overall conversion of
AGREI_RS15490	COG0022	dehydrogenase e1 component
AGREI_RS15500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AGREI_RS15540	COG1357	PFAM Pentapeptide repeats (8 copies)
AGREI_RS15570	COG1609	Transcriptional regulator
AGREI_RS15585	COG1131	(ABC) transporter
AGREI_RS15595	COG0667	Aldo Keto reductase
AGREI_RS15650	COG0656	L-ascorbic acid biosynthetic process
AGREI_RS15675	COG1309	transcriptional regulator
AGREI_RS15695	COG1215	transferase activity, transferring glycosyl groups
AGREI_RS15725	COG1609	Transcriptional regulator
AGREI_RS15730	COG0395	ABC-type sugar transport system, permease component
AGREI_RS15735	COG1175	transmembrane transport
AGREI_RS15745	COG4948	Mandelate Racemase Muconate Lactonizing
AGREI_RS15765	COG0800	Aldolase
AGREI_RS15770	COG3458	cephalosporin-C deacetylase activity
AGREI_RS15785	COG0673	inositol 2-dehydrogenase activity
AGREI_RS15805	COG0673	inositol 2-dehydrogenase activity
AGREI_RS15815	COG0402	S-adenosylhomocysteine deaminase activity
AGREI_RS15820	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AGREI_RS15825	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AGREI_RS15830	COG3639	organic phosphonate transmembrane transporter activity
AGREI_RS15850	COG0587	DNA-directed DNA polymerase activity
AGREI_RS15890	COG0587	DNA-directed DNA polymerase activity
AGREI_RS15915	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AGREI_RS15920	COG3454	Phosphonate metabolism
AGREI_RS15925	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AGREI_RS15930	COG4778	phosphonate C-P lyase system protein PhnL
AGREI_RS15935	COG4107	phosphonate C-P lyase system protein PhnK
AGREI_RS15940	COG3627	carbon phosphorus lyase activity
AGREI_RS15945	COG3626	phosphonate metabolism
AGREI_RS15955	COG3624	Phosphonate C-P lyase system protein PhnG
AGREI_RS15960	COG2186	Transcriptional regulator
AGREI_RS15990	COG0135	phosphoribosylanthranilate isomerase activity
AGREI_RS15995	COG2375	cellular response to nickel ion
AGREI_RS15995	COG1132	(ABC) transporter
AGREI_RS16000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AGREI_RS16005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_RS16010	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_RS16015	COG2197	response regulator
AGREI_RS16020	COG3850	Histidine kinase
AGREI_RS16030	COG1136	(ABC) transporter
AGREI_RS16030	COG0577	efflux transmembrane transporter activity
AGREI_RS16045	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_RS16070	COG1309	transcriptional regulator
AGREI_RS16075	COG0701	Predicted permease
AGREI_RS16095	COG0701	Predicted permease
AGREI_RS16125	COG3507	Belongs to the glycosyl hydrolase 43 family
AGREI_RS16155	COG1609	Transcriptional regulator
AGREI_RS16175	COG1819	glycosyl
AGREI_RS16190	COG1950	PFAM Membrane protein of
AGREI_RS16195	COG0697	spore germination
AGREI_RS16210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AGREI_RS16215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AGREI_RS16250	COG1674	ftsk spoiiie
AGREI_RS16270	COG0631	protein serine/threonine phosphatase activity
AGREI_RS16290	COG0714	Associated with various cellular activities
AGREI_RS16330	COG0667	Aldo Keto reductase
AGREI_RS16340	COG0305	Participates in initiation and elongation during chromosome replication
AGREI_RS16345	COG0359	binds to the 23S rRNA
AGREI_RS16350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AGREI_RS16360	COG0360	Binds together with S18 to 16S ribosomal RNA
AGREI_RS16370	COG1120	ATPase activity
AGREI_RS16380	COG4139	cobalamin transport
AGREI_RS16385	COG0617	tRNA 3'-terminal CCA addition
AGREI_RS16400	COG0492	ferredoxin-NADP+ reductase activity
AGREI_RS16405	COG3118	belongs to the thioredoxin family
AGREI_RS16410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AGREI_RS16430	COG1192	Involved in chromosome partitioning
AGREI_RS16435	COG0357	Ribosomal RNA small subunit methyltransferase G
AGREI_RS16445	COG0706	membrane insertase activity
AGREI_RS16450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AGREI_RS16455	COG0594	ribonuclease P activity
AGREI_RS16460	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AGREI_RS16470	COG0589	response to stress
AGREI_RS16475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AGREI_RS16490	COG0587	DNA-directed DNA polymerase activity
AGREI_RS16665	COG0542	response to heat
AGREI_RS16765	COG0446	pyridine nucleotide-disulphide oxidoreductase
AGREI_RS16775	COG0129	dihydroxy-acid dehydratase activity
AGREI_RS16785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AGREI_RS16790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity