locus-tag	class	description
At12D13_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
At12D13_RS00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
At12D13_RS00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
At12D13_RS00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
At12D13_RS00025	COG1420	regulation of RNA biosynthetic process
At12D13_RS00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
At12D13_RS00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
At12D13_RS00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
At12D13_RS00050	COG1137	ATPase activity
At12D13_RS00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
At12D13_RS00065	COG0616	signal peptide processing
At12D13_RS00070	COG0776	regulation of translation
At12D13_RS00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
At12D13_RS00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
At12D13_RS00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
At12D13_RS00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
At12D13_RS00115	COG0728	peptidoglycan biosynthetic process
At12D13_RS00125	COG0180	Tryptophanyl-tRNA synthetase
At12D13_RS00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
At12D13_RS00140	COG1214	PFAM Peptidase M22, glycoprotease
At12D13_RS00145	COG0456	acetyltransferase
At12D13_RS00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
At12D13_RS00165	COG1702	phosphate starvation-inducible protein PhoH
At12D13_RS00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
At12D13_RS00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
At12D13_RS00185	COG1396	sequence-specific DNA binding
At12D13_RS00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
At12D13_RS00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
At12D13_RS00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_RS00210	COG0242	peptide deformylase activity
At12D13_RS00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
At12D13_RS00220	COG0101	tRNA pseudouridine synthase activity
At12D13_RS00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
At12D13_RS00235	COG2171	N-acyltransferase activity
At12D13_RS00245	COG0840	transmembrane signaling receptor activity
At12D13_RS00255	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D13_RS00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
At12D13_RS00295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
At12D13_RS00300	COG0706	membrane insertase activity
At12D13_RS00305	COG0594	ribonuclease P activity
At12D13_RS00310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
At12D13_RS00320	COG0840	transmembrane signaling receptor activity
At12D13_RS00355	COG0328	RNA-DNA hybrid ribonuclease activity
At12D13_RS00380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
At12D13_RS00400	COG2226	methyltransferase
At12D13_RS00405	COG3842	ATPase activity
At12D13_RS00410	COG1175	transmembrane transport
At12D13_RS00415	COG0395	ABC-type sugar transport system, permease component
At12D13_RS00430	COG0427	acetyl-CoA hydrolase
At12D13_RS00440	COG3938	Belongs to the proline racemase family
At12D13_RS00445	COG0418	dihydroorotase activity
At12D13_RS00450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
At12D13_RS00470	COG0166	Belongs to the GPI family
At12D13_RS00475	COG0318	PFAM AMP-dependent synthetase and ligase
At12D13_RS00480	COG3842	ATPase activity
At12D13_RS00485	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D13_RS00490	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
At12D13_RS00495	COG4774	siderophore transport
At12D13_RS00560	COG2326	polyphosphate kinase activity
At12D13_RS00565	COG5002	protein histidine kinase activity
At12D13_RS00570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
At12D13_RS00575	COG0573	inorganic phosphate transmembrane transporter activity
At12D13_RS00585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
At12D13_RS00590	COG0704	Plays a role in the regulation of phosphate uptake
At12D13_RS00595	COG0745	RESPONSE REGULATOR receiver
At12D13_RS00610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
At12D13_RS00615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
At12D13_RS00625	COG2967	ApaG domain
At12D13_RS00635	COG0717	Belongs to the dCTP deaminase family
At12D13_RS00645	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
At12D13_RS00665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
At12D13_RS00715	COG0167	dihydroorotate dehydrogenase activity
At12D13_RS00730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
At12D13_RS00750	COG1959	2 iron, 2 sulfur cluster binding
At12D13_RS00755	COG1201	RNA secondary structure unwinding
At12D13_RS00775	COG0730	response to heat
At12D13_RS00790	COG1960	acyl-CoA dehydrogenase activity
At12D13_RS00795	COG0183	Belongs to the thiolase family
At12D13_RS00805	COG1250	3-hydroxyacyl-CoA dehydrogenase
At12D13_RS00805	COG1024	Enoyl-CoA hydratase
At12D13_RS00830	COG1320	monovalent cation:proton antiporter activity
At12D13_RS00835	COG2212	antiporter activity
At12D13_RS00840	COG1863	multisubunit Na H antiporter MnhE subunit
At12D13_RS00845	COG0651	ATP synthesis coupled electron transport
At12D13_RS00850	COG1006	Multisubunit Na H antiporter MnhC subunit
At12D13_RS00855	COG2111	Na H antiporter
At12D13_RS00855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
At12D13_RS00865	COG0840	transmembrane signaling receptor activity
At12D13_RS00875	COG0745	RESPONSE REGULATOR receiver
At12D13_RS00880	COG2198	Histidine kinase
At12D13_RS00880	COG0643	Histidine kinase
At12D13_RS00885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
At12D13_RS00890	COG2201	protein-glutamate methylesterase activity
At12D13_RS00895	COG0745	RESPONSE REGULATOR receiver
At12D13_RS00900	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
At12D13_RS00910	COG1766	The M ring may be actively involved in energy transduction
At12D13_RS00915	COG2771	luxR family
At12D13_RS00925	COG0840	transmembrane signaling receptor activity
At12D13_RS00925	COG2972	Histidine kinase
At12D13_RS00930	COG0784	Response regulator, receiver
At12D13_RS00930	COG2205	protein histidine kinase activity
At12D13_RS00930	COG2198	Histidine kinase
At12D13_RS00935	COG1970	mechanosensitive ion channel activity
At12D13_RS00940	COG0436	Aminotransferase
At12D13_RS00955	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
At12D13_RS00960	COG0424	maF-like protein
At12D13_RS00965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
At12D13_RS00975	COG5328	Belongs to the UPF0262 family
At12D13_RS00980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
At12D13_RS00990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
At12D13_RS01005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
At12D13_RS01025	COG1338	Plays a role in the flagellum-specific transport system
At12D13_RS01035	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
At12D13_RS01045	COG1706	bacterial-type flagellum-dependent cell motility
At12D13_RS01050	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
At12D13_RS01055	COG4786	Flagellar basal body rod
At12D13_RS01060	COG1677	Flagellar hook-basal body complex protein FliE
At12D13_RS01065	COG1558	bacterial-type flagellum-dependent cell motility
At12D13_RS01070	COG1815	bacterial-type flagellum-dependent cell motility
At12D13_RS01080	COG1157	protein secretion by the type III secretion system
At12D13_RS01085	COG4786	Flagellar basal body rod
At12D13_RS01095	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
At12D13_RS01100	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
At12D13_RS01105	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
At12D13_RS01110	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
At12D13_RS01115	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
At12D13_RS01140	COG1360	Flagellar Motor Protein
At12D13_RS01165	COG1749	Flagellar hook protein flgE
At12D13_RS01185	COG5443	negative regulation of bacterial-type flagellum assembly
At12D13_RS01190	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
At12D13_RS01200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
At12D13_RS01240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
At12D13_RS01245	COG1609	Transcriptional regulator
At12D13_RS01250	COG1653	transport
At12D13_RS01255	COG1175	transmembrane transport
At12D13_RS01260	COG0395	ABC-type sugar transport system, permease component
At12D13_RS01265	COG0366	Alpha amylase catalytic
At12D13_RS01270	COG3842	ATPase activity
At12D13_RS01280	COG3609	addiction module antidote protein, CC2985 family
At12D13_RS01295	COG0129	dihydroxy-acid dehydratase activity
At12D13_RS01300	COG0363	glucosamine-6-phosphate deaminase activity
At12D13_RS01305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
At12D13_RS01310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS01320	COG2081	HI0933 family
At12D13_RS01340	COG2224	Isocitrate lyase
At12D13_RS01355	COG3842	ATPase activity
At12D13_RS01360	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D13_RS01365	COG1177	transmembrane transport
At12D13_RS01375	COG2205	protein histidine kinase activity
At12D13_RS01385	COG0248	Ppx GppA phosphatase
At12D13_RS01390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
At12D13_RS01395	COG0477	Major facilitator Superfamily
At12D13_RS01445	COG0521	Mo-molybdopterin cofactor biosynthetic process
At12D13_RS01450	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
At12D13_RS01460	COG0142	geranyltranstransferase activity
At12D13_RS01485	COG0752	glycyl-tRNA synthetase alpha subunit
At12D13_RS01495	COG1704	LemA family
At12D13_RS01500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
At12D13_RS01510	COG0751	glycine-tRNA ligase activity
At12D13_RS01520	COG1683	Conserved Protein
At12D13_RS01525	COG0840	transmembrane signaling receptor activity
At12D13_RS01535	COG0151	Belongs to the GarS family
At12D13_RS01545	COG2183	response to ionizing radiation
At12D13_RS01550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
At12D13_RS01560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
At12D13_RS01575	COG0583	DNA-binding transcription factor activity
At12D13_RS01595	COG0306	phosphate transporter
At12D13_RS01605	COG0561	phosphatase activity
At12D13_RS01610	COG0438	transferase activity, transferring glycosyl groups
At12D13_RS01615	COG2186	Transcriptional regulator
At12D13_RS01630	COG0583	DNA-binding transcription factor activity
At12D13_RS01635	COG0277	FAD linked oxidase domain protein
At12D13_RS01645	COG0277	FAD linked oxidase domain protein
At12D13_RS01650	COG0247	lactate metabolic process
At12D13_RS01660	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_RS01665	COG0519	Catalyzes the synthesis of GMP from XMP
At12D13_RS01675	COG2855	membrane
At12D13_RS01680	COG0583	DNA-binding transcription factor activity
At12D13_RS01700	COG0124	histidyl-tRNA synthetase
At12D13_RS01710	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
At12D13_RS01715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
At12D13_RS01720	COG2259	Doxx family
At12D13_RS01735	COG0459	protein refolding
At12D13_RS01740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
At12D13_RS01750	COG0196	riboflavin kinase activity
At12D13_RS01755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
At12D13_RS01765	COG0590	tRNA wobble adenosine to inosine editing
At12D13_RS01770	COG1187	pseudouridine synthase activity
At12D13_RS01775	COG0742	ribosomal rna small subunit methyltransferase
At12D13_RS01780	COG1752	Esterase of the alpha-beta hydrolase superfamily
At12D13_RS01785	COG0475	glutathione-regulated potassium exporter activity
At12D13_RS01785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
At12D13_RS01790	COG0312	modulator of DNA gyrase
At12D13_RS01795	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_RS01805	COG1519	Transferase
At12D13_RS01815	COG1663	tetraacyldisaccharide 4'-kinase activity
At12D13_RS01825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
At12D13_RS01835	COG3300	MHYT domain
At12D13_RS01835	COG5001	Diguanylate cyclase
At12D13_RS01840	COG3386	PFAM SMP-30 Gluconolaconase
At12D13_RS01845	COG0800	Aldolase
At12D13_RS01850	COG3734	2-keto-3-deoxy-galactonokinase
At12D13_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS01865	COG2197	response regulator
At12D13_RS01870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D13_RS01880	COG0598	Magnesium transport protein CorA
At12D13_RS01885	COG3158	transport of potassium into the cell
At12D13_RS01900	COG0356	it plays a direct role in the translocation of protons across the membrane
At12D13_RS01910	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
At12D13_RS01915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
At12D13_RS01930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
At12D13_RS01950	COG0009	L-threonylcarbamoyladenylate synthase
At12D13_RS01960	COG4638	Rieske (2fe-2S)
At12D13_RS01985	COG1960	acyl-CoA dehydrogenase activity
At12D13_RS02005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
At12D13_RS02010	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
At12D13_RS02015	COG0840	transmembrane signaling receptor activity
At12D13_RS02025	COG1522	sequence-specific DNA binding
At12D13_RS02055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
At12D13_RS02060	COG1741	Belongs to the pirin family
At12D13_RS02065	COG1722	exodeoxyribonuclease VII activity
At12D13_RS02070	COG0123	including yeast histone deacetylase and acetoin utilization protein
At12D13_RS02075	COG1268	BioY protein
At12D13_RS02080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
At12D13_RS02085	COG1122	ATPase activity
At12D13_RS02090	COG3214	Protein conserved in bacteria
At12D13_RS02095	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
At12D13_RS02095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
At12D13_RS02100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
At12D13_RS02115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
At12D13_RS02130	COG0259	pyridoxamine-phosphate oxidase activity
At12D13_RS02145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
At12D13_RS02155	COG0312	modulator of DNA gyrase
At12D13_RS02170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D13_RS02175	COG0109	protoheme IX farnesyltransferase activity
At12D13_RS02185	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
At12D13_RS02200	COG3346	SURF1 family
At12D13_RS02205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
At12D13_RS02210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
At12D13_RS02215	COG0328	RNA-DNA hybrid ribonuclease activity
At12D13_RS02230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
At12D13_RS02230	COG0678	peroxiredoxin activity
At12D13_RS02240	COG1678	Uncharacterized ACR, COG1678
At12D13_RS02260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
At12D13_RS02265	COG0612	Peptidase, M16
At12D13_RS02280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
At12D13_RS02285	COG1802	Transcriptional regulator
At12D13_RS02305	COG2189	Belongs to the N(4) N(6)-methyltransferase family
At12D13_RS02315	COG3609	addiction module antidote protein, CC2985 family
At12D13_RS02330	COG1194	a g-specific adenine glycosylase
At12D13_RS02340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
At12D13_RS02345	COG1196	nuclear chromosome segregation
At12D13_RS02355	COG2514	catechol 2,3-dioxygenase activity
At12D13_RS02360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
At12D13_RS02360	COG0574	Belongs to the PEP-utilizing enzyme family
At12D13_RS02375	COG1823	symporter activity
At12D13_RS02415	COG0579	oxidoreductase
At12D13_RS02440	COG2895	sulfate adenylyltransferase (ATP) activity
At12D13_RS02445	COG0175	sulfate reduction
At12D13_RS02450	COG0175	sulfate reduction
At12D13_RS02455	COG1959	2 iron, 2 sulfur cluster binding
At12D13_RS02460	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
At12D13_RS02465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
At12D13_RS02470	COG4208	sulfate ABC transporter
At12D13_RS02475	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
At12D13_RS02495	COG2199	diguanylate cyclase activity
At12D13_RS02495	COG2203	Gaf domain
At12D13_RS02495	COG2200	EAL domain
At12D13_RS02505	COG1309	transcriptional regulator
At12D13_RS02510	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_RS02520	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
At12D13_RS02565	COG0477	Major facilitator Superfamily
At12D13_RS02575	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
At12D13_RS02575	COG1793	dna ligase
At12D13_RS02595	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_RS02600	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_RS02605	COG1846	Transcriptional regulator
At12D13_RS02610	COG1764	response to oxidative stress
At12D13_RS02625	COG0488	(ABC) transporter
At12D13_RS02660	COG4221	oxidoreductase activity
At12D13_RS02675	COG0433	COG0433 Predicted ATPase
At12D13_RS02690	COG1733	regulation of RNA biosynthetic process
At12D13_RS02695	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
At12D13_RS02715	COG0656	L-ascorbic acid biosynthetic process
At12D13_RS02720	COG3781	membrane
At12D13_RS02725	COG2378	regulation of single-species biofilm formation
At12D13_RS02735	COG4106	trans-aconitate 2-methyltransferase activity
At12D13_RS02740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
At12D13_RS02745	COG0840	transmembrane signaling receptor activity
At12D13_RS02750	COG0583	DNA-binding transcription factor activity
At12D13_RS02765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
At12D13_RS02775	COG2378	regulation of single-species biofilm formation
At12D13_RS02785	COG3909	cytochrome
At12D13_RS02790	COG2010	Cytochrome c
At12D13_RS02820	COG0789	Transcriptional regulator
At12D13_RS02845	COG0517	IMP dehydrogenase activity
At12D13_RS02845	COG4175	Glycine betaine
At12D13_RS02850	COG4176	ABC-type proline glycine betaine transport system permease component
At12D13_RS02875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_RS02885	COG2169	Transcriptional regulator
At12D13_RS02885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
At12D13_RS02895	COG2514	catechol 2,3-dioxygenase activity
At12D13_RS02915	COG1272	protein, Hemolysin III
At12D13_RS02925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
At12D13_RS02930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
At12D13_RS02930	COG2111	Na H antiporter
At12D13_RS02935	COG2111	Na H antiporter
At12D13_RS02940	COG1006	Multisubunit Na H antiporter MnhC subunit
At12D13_RS02945	COG0651	ATP synthesis coupled electron transport
At12D13_RS02950	COG1863	multisubunit Na H antiporter MnhE subunit
At12D13_RS02955	COG2212	antiporter activity
At12D13_RS02960	COG1320	monovalent cation:proton antiporter activity
At12D13_RS02965	COG4957	zinc ion binding
At12D13_RS02980	COG2166	iron-sulfur cluster assembly
At12D13_RS02990	COG2205	protein histidine kinase activity
At12D13_RS03065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
At12D13_RS03070	COG2983	Belongs to the UPF0260 family
At12D13_RS03085	COG2217	Heavy metal translocating P-type atpase
At12D13_RS03105	COG2337	Toxic component of a toxin-antitoxin (TA) module
At12D13_RS03125	COG1621	beta-fructofuranosidase activity
At12D13_RS03130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
At12D13_RS03185	COG4695	Portal protein
At12D13_RS03290	COG4235	cytochrome complex assembly
At12D13_RS03295	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
At12D13_RS03300	COG1138	Cytochrome C-type biogenesis protein
At12D13_RS03305	COG3088	subunit of a heme lyase
At12D13_RS03310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
At12D13_RS03325	COG3713	MltA-interacting MipA family protein
At12D13_RS03330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
At12D13_RS03340	COG2205	protein histidine kinase activity
At12D13_RS03340	COG2202	Pas domain
At12D13_RS03350	COG0308	aminopeptidase N
At12D13_RS03355	COG0697	spore germination
At12D13_RS03375	COG0443	Heat shock 70 kDa protein
At12D13_RS03415	COG0604	alcohol dehydrogenase
At12D13_RS03420	COG1733	regulation of RNA biosynthetic process
At12D13_RS03425	COG1968	undecaprenyl-diphosphatase activity
At12D13_RS03430	COG2239	Acts as a magnesium transporter
At12D13_RS03435	COG2814	Major facilitator Superfamily
At12D13_RS03465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
At12D13_RS03490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
At12D13_RS03540	COG0741	lytic transglycosylase activity
At12D13_RS03550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_RS03555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
At12D13_RS03565	COG0840	transmembrane signaling receptor activity
At12D13_RS03575	COG1758	RNA polymerase activity
At12D13_RS03595	COG0736	holo-[acyl-carrier-protein] synthase activity
At12D13_RS03600	COG0681	Belongs to the peptidase S26 family
At12D13_RS03605	COG0571	ribonuclease III activity
At12D13_RS03610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
At12D13_RS03615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
At12D13_RS03620	COG0784	Response regulator, receiver
At12D13_RS03625	COG1381	Involved in DNA repair and RecF pathway recombination
At12D13_RS03635	COG2226	methyltransferase
At12D13_RS03645	COG1418	mRNA catabolic process
At12D13_RS03655	COG0346	lactoylglutathione lyase activity
At12D13_RS03665	COG1116	anion transmembrane transporter activity
At12D13_RS03670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_RS03675	COG3443	Belongs to the bacterial solute-binding protein 9 family
At12D13_RS03680	COG0668	transmembrane transport
At12D13_RS03690	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
At12D13_RS03715	COG1051	belongs to the nudix hydrolase family
At12D13_RS03720	COG1742	UPF0060 membrane protein
At12D13_RS03740	COG1183	phosphatidylcholine synthase activity
At12D13_RS03745	COG0688	phosphatidylethanolamine metabolic process
At12D13_RS03750	COG5265	(ABC) transporter
At12D13_RS03755	COG1652	LysM domain
At12D13_RS03790	COG2852	Protein conserved in bacteria
At12D13_RS03795	COG0215	cysteine-tRNA ligase activity
At12D13_RS03800	COG4221	oxidoreductase activity
At12D13_RS03805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
At12D13_RS03810	COG1286	toxin biosynthetic process
At12D13_RS03830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
At12D13_RS03840	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
At12D13_RS03850	COG5265	(ABC) transporter
At12D13_RS03855	COG0305	Participates in initiation and elongation during chromosome replication
At12D13_RS03880	COG0359	binds to the 23S rRNA
At12D13_RS03890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
At12D13_RS03895	COG0360	Binds together with S18 to 16S ribosomal RNA
At12D13_RS03905	COG0667	Aldo Keto reductase
At12D13_RS03910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
At12D13_RS03920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
At12D13_RS03925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
At12D13_RS03935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
At12D13_RS03940	COG1561	YicC-like family, N-terminal region
At12D13_RS03945	COG0194	GDP metabolic process
At12D13_RS03955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
At12D13_RS03960	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
At12D13_RS03970	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
At12D13_RS03985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
At12D13_RS04005	COG5001	Diguanylate cyclase
At12D13_RS04005	COG3300	MHYT domain
At12D13_RS04010	COG4191	Histidine kinase
At12D13_RS04025	COG0488	(ABC) transporter
At12D13_RS04030	COG3706	GGDEF domain
At12D13_RS04040	COG0105	UTP biosynthetic process
At12D13_RS04060	COG0314	molybdopterin synthase activity
At12D13_RS04065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
At12D13_RS04070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
At12D13_RS04075	COG0322	excinuclease ABC activity
At12D13_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS04090	COG0625	glutathione transferase activity
At12D13_RS04110	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
At12D13_RS04115	COG0243	molybdopterin cofactor binding
At12D13_RS04130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
At12D13_RS04135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
At12D13_RS04140	COG0628	permease
At12D13_RS04150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
At12D13_RS04155	COG0248	Ppx GppA phosphatase
At12D13_RS04180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
At12D13_RS04190	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
At12D13_RS04195	COG0477	Major facilitator Superfamily
At12D13_RS04200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
At12D13_RS04210	COG4452	Inner membrane protein CreD
At12D13_RS04215	COG0659	secondary active sulfate transmembrane transporter activity
At12D13_RS04225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
At12D13_RS04230	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
At12D13_RS04240	COG0113	porphobilinogen synthase activity
At12D13_RS04260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
At12D13_RS04265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
At12D13_RS04270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
At12D13_RS04270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
At12D13_RS04280	COG1280	lysine exporter protein (LysE YggA)
At12D13_RS04285	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
At12D13_RS04290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
At12D13_RS04295	COG2814	Major facilitator Superfamily
At12D13_RS04300	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
At12D13_RS04320	COG0416	fatty acid biosynthetic process
At12D13_RS04325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
At12D13_RS04330	COG0776	regulation of translation
At12D13_RS04365	COG0601	transmembrane transport
At12D13_RS04370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS04375	COG0444	Belongs to the ABC transporter superfamily
At12D13_RS04395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
At12D13_RS04400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
At12D13_RS04415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
At12D13_RS04420	COG0583	DNA-binding transcription factor activity
At12D13_RS04425	COG0737	Belongs to the 5'-nucleotidase family
At12D13_RS04450	COG2897	thiosulfate sulfurtransferase activity
At12D13_RS04465	COG0415	Belongs to the DNA photolyase family
At12D13_RS04475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
At12D13_RS04590	COG3932	Exopolysaccharide synthesis, ExoD
At12D13_RS04670	COG1612	heme a metabolic process
At12D13_RS04680	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
At12D13_RS04685	COG0010	Belongs to the arginase family
At12D13_RS04690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
At12D13_RS04695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
At12D13_RS04710	COG1832	CoA-binding protein
At12D13_RS04735	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS04740	COG2124	cytochrome p450
At12D13_RS04745	COG2199	diguanylate cyclase activity
At12D13_RS04750	COG0740	serine-type endopeptidase activity
At12D13_RS04755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
At12D13_RS04765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
At12D13_RS04775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
At12D13_RS04800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D13_RS04805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D13_RS04810	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D13_RS04820	COG0649	NAD binding
At12D13_RS04830	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
At12D13_RS04835	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
At12D13_RS04845	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
At12D13_RS04850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D13_RS04860	COG0713	ATP synthesis coupled electron transport
At12D13_RS04875	COG1007	ATP synthesis coupled electron transport
At12D13_RS04900	COG0442	prolyl-tRNA aminoacylation
At12D13_RS04910	COG1136	(ABC) transporter
At12D13_RS04930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
At12D13_RS04940	COG0784	Response regulator, receiver
At12D13_RS04955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
At12D13_RS04960	COG0477	Major facilitator Superfamily
At12D13_RS04975	COG0557	exoribonuclease II activity
At12D13_RS04980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
At12D13_RS04990	COG0758	DNA mediated transformation
At12D13_RS04995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
At12D13_RS05005	COG0540	Belongs to the ATCase OTCase family
At12D13_RS05015	COG1960	acyl-CoA dehydrogenase activity
At12D13_RS05020	COG0456	acetyltransferase
At12D13_RS05045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
At12D13_RS05050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
At12D13_RS05055	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
At12D13_RS05060	COG0154	amidase activity
At12D13_RS05065	COG0456	acetyltransferase
At12D13_RS05070	COG3811	Belongs to the UPF0386 family
At12D13_RS05085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
At12D13_RS05095	COG0456	acetyltransferase
At12D13_RS05110	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
At12D13_RS05115	COG0439	Biotin carboxylase
At12D13_RS05120	COG0511	ligase activity, forming carbon-carbon bonds
At12D13_RS05125	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
At12D13_RS05135	COG0436	Aminotransferase
At12D13_RS05155	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS05160	COG1530	ribonuclease E activity
At12D13_RS05175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
At12D13_RS05195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
At12D13_RS05200	COG0384	phenazine biosynthesis protein PhzF
At12D13_RS05215	COG0633	Ferredoxin
At12D13_RS05225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
At12D13_RS05230	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
At12D13_RS05235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
At12D13_RS05245	COG3768	UPF0283 membrane protein
At12D13_RS05250	COG3106	COG3106 Predicted ATPase
At12D13_RS05280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
At12D13_RS05310	COG0537	adenosine 5'-monophosphoramidase activity
At12D13_RS05335	COG0052	Belongs to the universal ribosomal protein uS2 family
At12D13_RS05340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
At12D13_RS05345	COG0528	UMP kinase activity
At12D13_RS05350	COG0233	cytoplasmic translational termination
At12D13_RS05355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
At12D13_RS05365	COG0750	zinc metalloprotease
At12D13_RS05370	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
At12D13_RS05375	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
At12D13_RS05380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
At12D13_RS05385	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
At12D13_RS05390	COG3494	Protein of unknown function (DUF1009)
At12D13_RS05395	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
At12D13_RS05400	COG2186	Transcriptional regulator
At12D13_RS05410	COG0765	amino acid transport
At12D13_RS05415	COG0765	amino acid transport
At12D13_RS05425	COG0372	Belongs to the citrate synthase family
At12D13_RS05440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
At12D13_RS05445	COG4598	ABC transporter
At12D13_RS05450	COG0765	amino acid transport
At12D13_RS05455	COG0765	amino acid transport
At12D13_RS05460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS05465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_RS05470	COG3842	ATPase activity
At12D13_RS05475	COG0395	ABC-type sugar transport system, permease component
At12D13_RS05485	COG2182	Extracellular solute-binding protein
At12D13_RS05495	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_RS05500	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS05505	COG1063	alcohol dehydrogenase
At12D13_RS05510	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
At12D13_RS05530	COG0683	leucine binding
At12D13_RS05535	COG1960	acyl-CoA dehydrogenase activity
At12D13_RS05550	COG1024	Enoyl-CoA hydratase
At12D13_RS05565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D13_RS05585	COG2877	3-deoxy-8-phosphooctulonate synthase activity
At12D13_RS05590	COG0148	phosphopyruvate hydratase activity
At12D13_RS05605	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
At12D13_RS05610	COG0508	dehydrogenase complex catalyzes the overall conversion of
At12D13_RS05610	COG0022	dehydrogenase e1 component
At12D13_RS05620	COG0508	dehydrogenase complex catalyzes the overall conversion of
At12D13_RS05630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
At12D13_RS05640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
At12D13_RS05645	COG0697	spore germination
At12D13_RS05670	COG2867	negative regulation of translational initiation
At12D13_RS05675	COG1546	Belongs to the CinA family
At12D13_RS05680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
At12D13_RS05680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
At12D13_RS05690	COG3852	Histidine kinase
At12D13_RS05695	COG2204	response regulator
At12D13_RS05700	COG5000	phosphorelay sensor kinase activity
At12D13_RS05705	COG2204	response regulator
At12D13_RS05710	COG0569	domain protein
At12D13_RS05715	COG1923	regulation of RNA biosynthetic process
At12D13_RS05720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
At12D13_RS05725	COG3956	TIGRFAM MazG family protein
At12D13_RS05735	COG1648	precorrin-2 dehydrogenase activity
At12D13_RS05735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
At12D13_RS05750	COG0275	rRNA processing
At12D13_RS05775	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
At12D13_RS05775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
At12D13_RS05780	COG0509	glycine decarboxylation via glycine cleavage system
At12D13_RS05785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D13_RS05810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
At12D13_RS05815	COG0564	pseudouridine synthase activity
At12D13_RS05835	COG0251	oxidation-reduction process
At12D13_RS05840	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
At12D13_RS05850	COG1671	Belongs to the UPF0178 family
At12D13_RS05860	COG0450	alkyl hydroperoxide reductase
At12D13_RS05910	COG0431	NADPH-dependent FMN reductase
At12D13_RS05940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
At12D13_RS05940	COG0321	lipoyl(octanoyl) transferase activity
At12D13_RS05945	COG0084	hydrolase, TatD family'
At12D13_RS05950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
At12D13_RS05960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
At12D13_RS06020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
At12D13_RS06025	COG2095	MarC family integral membrane protein
At12D13_RS06030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
At12D13_RS06030	COG0617	tRNA 3'-terminal CCA addition
At12D13_RS06030	COG0517	IMP dehydrogenase activity
At12D13_RS06040	COG3609	addiction module antidote protein, CC2985 family
At12D13_RS06045	COG0629	single-stranded DNA binding
At12D13_RS06050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
At12D13_RS06060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
At12D13_RS06065	COG0179	Fumarylacetoacetate (FAA) hydrolase
At12D13_RS06080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
At12D13_RS06085	COG1121	(ABC) transporter
At12D13_RS06105	COG0667	Aldo Keto reductase
At12D13_RS06115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
At12D13_RS06185	COG0668	transmembrane transport
At12D13_RS06215	COG2239	Acts as a magnesium transporter
At12D13_RS06220	COG0243	molybdopterin cofactor binding
At12D13_RS06230	COG0242	peptide deformylase activity
At12D13_RS06260	COG0321	lipoyl(octanoyl) transferase activity
At12D13_RS06265	COG1064	alcohol dehydrogenase
At12D13_RS06295	COG1862	Preprotein translocase
At12D13_RS06320	COG1309	transcriptional regulator
At12D13_RS06325	COG2124	cytochrome p450
At12D13_RS06340	COG0596	Alpha beta hydrolase
At12D13_RS06350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
At12D13_RS06355	COG0626	cystathionine gamma-synthase activity
At12D13_RS06360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS06365	COG4597	amino acid ABC transporter
At12D13_RS06370	COG0765	amino acid transport
At12D13_RS06375	COG1126	abc transporter atp-binding protein
At12D13_RS06395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
At12D13_RS06410	COG0436	Aminotransferase
At12D13_RS06440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
At12D13_RS06450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
At12D13_RS06455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
At12D13_RS06460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
At12D13_RS06475	COG3243	poly(R)-hydroxyalkanoic acid synthase
At12D13_RS06480	COG1489	DNA binding
At12D13_RS06485	COG0024	Methionine aminopeptidase
At12D13_RS06490	COG2003	Belongs to the UPF0758 family
At12D13_RS06505	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
At12D13_RS06520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
At12D13_RS06525	COG0546	phosphoglycolate phosphatase activity
At12D13_RS06535	COG0114	fumarate hydratase activity
At12D13_RS06540	COG0657	acetylesterase activity
At12D13_RS06540	COG2755	lipolytic protein G-D-S-L family
At12D13_RS06545	COG0504	CTP synthase activity
At12D13_RS06555	COG0149	triose-phosphate isomerase activity
At12D13_RS06565	COG0187	DNA topoisomerase II activity
At12D13_RS06575	COG1309	transcriptional regulator
At12D13_RS06580	COG2226	methyltransferase
At12D13_RS06585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_RS06590	COG0740	serine-type endopeptidase activity
At12D13_RS06600	COG0640	Transcriptional regulator
At12D13_RS06605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
At12D13_RS06610	COG0745	RESPONSE REGULATOR receiver
At12D13_RS06620	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
At12D13_RS06620	COG3264	Mechanosensitive ion channel
At12D13_RS06690	COG1127	ABC transporter
At12D13_RS06695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
At12D13_RS06700	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_RS06715	COG0280	phosphate acetyltransferase
At12D13_RS06715	COG0281	malic enzyme
At12D13_RS06725	COG0778	Nitroreductase
At12D13_RS06730	COG0823	Involved in the tonB-independent uptake of proteins
At12D13_RS06740	COG1368	sulfuric ester hydrolase activity
At12D13_RS06770	COG0544	peptidyl-prolyl cis-trans isomerase activity
At12D13_RS06795	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
At12D13_RS06800	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
At12D13_RS06815	COG0318	PFAM AMP-dependent synthetase and ligase
At12D13_RS06830	COG0343	queuine tRNA-ribosyltransferase activity
At12D13_RS06835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
At12D13_RS06850	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
At12D13_RS06875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
At12D13_RS06880	COG0134	indole-3-glycerol-phosphate synthase activity
At12D13_RS06885	COG0315	cyclic pyranopterin monophosphate synthase activity
At12D13_RS06890	COG0303	'Molybdopterin
At12D13_RS06895	COG3706	GGDEF domain
At12D13_RS06905	COG0475	glutathione-regulated potassium exporter activity
At12D13_RS06905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
At12D13_RS06915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
At12D13_RS06920	COG0697	spore germination
At12D13_RS06925	COG2814	Major facilitator Superfamily
At12D13_RS06930	COG0746	molybdenum cofactor guanylyltransferase activity
At12D13_RS06935	COG1763	Mo-molybdopterin cofactor biosynthetic process
At12D13_RS06940	COG0739	heme binding
At12D13_RS06945	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
At12D13_RS06950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
At12D13_RS06955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
At12D13_RS06960	COG0805	protein transport
At12D13_RS06965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
At12D13_RS06970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
At12D13_RS06975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
At12D13_RS06980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
At12D13_RS06985	COG1472	Belongs to the glycosyl hydrolase 3 family
At12D13_RS06995	COG0018	arginyl-trna synthetase
At12D13_RS07000	COG0232	Belongs to the dGTPase family. Type 2 subfamily
At12D13_RS07005	COG0316	Belongs to the HesB IscA family
At12D13_RS07015	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
At12D13_RS07035	COG0525	valine-tRNA ligase activity
At12D13_RS07045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
At12D13_RS07090	COG0655	NAD(P)H dehydrogenase (quinone) activity
At12D13_RS07095	COG1546	Belongs to the CinA family
At12D13_RS07095	COG1058	Belongs to the CinA family
At12D13_RS07100	COG0589	response to stress
At12D13_RS07105	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
At12D13_RS07110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
At12D13_RS07125	COG1914	H( )-stimulated, divalent metal cation uptake system
At12D13_RS07135	COG1132	(ABC) transporter
At12D13_RS07140	COG0628	permease
At12D13_RS07160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
At12D13_RS07175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
At12D13_RS07185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
At12D13_RS07195	COG0302	gtp cyclohydrolase
At12D13_RS07200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
At12D13_RS07205	COG1752	Esterase of the alpha-beta hydrolase superfamily
At12D13_RS07210	COG0516	GMP reductase activity
At12D13_RS07210	COG0517	IMP dehydrogenase activity
At12D13_RS07245	COG1760	l-serine dehydratase
At12D13_RS07280	COG0583	DNA-binding transcription factor activity
At12D13_RS07295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
At12D13_RS07295	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
At12D13_RS07300	COG0347	Belongs to the P(II) protein family
At12D13_RS07305	COG0174	glutamine synthetase
At12D13_RS07335	COG0697	spore germination
At12D13_RS07350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
At12D13_RS07360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
At12D13_RS07370	COG3668	Plasmid stabilization system
At12D13_RS07375	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
At12D13_RS07390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
At12D13_RS07395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
At12D13_RS07400	COG2186	Transcriptional regulator
At12D13_RS07410	COG1079	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS07415	COG4603	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS07420	COG3845	ABC transporter
At12D13_RS07425	COG1183	phosphatidylcholine synthase activity
At12D13_RS07430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
At12D13_RS07435	COG0679	Auxin Efflux Carrier
At12D13_RS07440	COG0785	Cytochrome C biogenesis protein
At12D13_RS07480	COG1278	Cold shock
At12D13_RS07540	COG2267	carboxylic ester hydrolase activity
At12D13_RS07555	COG1136	(ABC) transporter
At12D13_RS07555	COG0577	efflux transmembrane transporter activity
At12D13_RS07560	COG0577	efflux transmembrane transporter activity
At12D13_RS07560	COG1136	(ABC) transporter
At12D13_RS07575	COG2151	metal-sulfur cluster biosynthetic enzyme
At12D13_RS07580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
At12D13_RS07585	COG0719	Fe-S assembly protein
At12D13_RS07590	COG0396	ATPase activity
At12D13_RS07600	COG0719	Fe-S assembly protein
At12D13_RS07605	COG1104	cysteine desulfurase activity
At12D13_RS07610	COG2945	thiolester hydrolase activity
At12D13_RS07620	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
At12D13_RS07625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
At12D13_RS07635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
At12D13_RS07640	COG2833	Protein of unknown function (DUF455)
At12D13_RS07645	COG0739	heme binding
At12D13_RS07650	COG0513	Belongs to the DEAD box helicase family
At12D13_RS07690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
At12D13_RS07700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
At12D13_RS07705	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
At12D13_RS07710	COG0047	phosphoribosylformylglycinamidine synthase activity
At12D13_RS07725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D13_RS07735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
At12D13_RS07755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
At12D13_RS07760	COG2814	Major facilitator Superfamily
At12D13_RS07765	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_RS07770	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_RS07775	COG0037	tRNA processing
At12D13_RS07780	COG2066	Belongs to the glutaminase family
At12D13_RS07785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
At12D13_RS07790	COG0861	Integral membrane protein TerC family
At12D13_RS07805	COG1280	lysine exporter protein (LysE YggA)
At12D13_RS07820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
At12D13_RS07825	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
At12D13_RS07835	COG0538	isocitrate dehydrogenase activity
At12D13_RS07860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
At12D13_RS07865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
At12D13_RS07870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_RS07875	COG2313	pseudouridylate synthase activity
At12D13_RS07890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS07895	COG4215	(ABC) transporter
At12D13_RS07905	COG5425	PFAM Usg family protein
At12D13_RS07915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D13_RS07920	COG1522	sequence-specific DNA binding
At12D13_RS07925	COG1573	uracil-dna glycosylase
At12D13_RS07935	COG2205	protein histidine kinase activity
At12D13_RS07935	COG2202	Pas domain
At12D13_RS07945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
At12D13_RS07950	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
At12D13_RS07965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
At12D13_RS07975	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS07980	COG1129	ABC transporter
At12D13_RS07990	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS08000	COG3959	Transketolase, thiamine diphosphate binding domain
At12D13_RS08005	COG3958	Transketolase
At12D13_RS08010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
At12D13_RS08015	COG2390	Transcriptional regulator
At12D13_RS08025	COG0842	Transport permease protein
At12D13_RS08030	COG1131	(ABC) transporter
At12D13_RS08035	COG0730	response to heat
At12D13_RS08065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
At12D13_RS08070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
At12D13_RS08085	COG0129	dihydroxy-acid dehydratase activity
At12D13_RS08090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
At12D13_RS08095	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
At12D13_RS08105	COG3739	integral membrane protein
At12D13_RS08110	COG0203	ribosomal protein L17
At12D13_RS08115	COG0202	RNA polymerase activity
At12D13_RS08120	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
At12D13_RS08125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
At12D13_RS08130	COG0563	adenylate kinase activity
At12D13_RS08135	COG0201	protein transport
At12D13_RS08140	COG0200	Binds to the 23S rRNA
At12D13_RS08145	COG1841	ribosomal large subunit assembly
At12D13_RS08150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
At12D13_RS08155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
At12D13_RS08160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
At12D13_RS08165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
At12D13_RS08170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
At12D13_RS08175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
At12D13_RS08180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
At12D13_RS08185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
At12D13_RS08190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
At12D13_RS08195	COG0255	Belongs to the universal ribosomal protein uL29 family
At12D13_RS08200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
At12D13_RS08205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
At12D13_RS08210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
At12D13_RS08215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
At12D13_RS08220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
At12D13_RS08225	COG0089	rRNA binding
At12D13_RS08230	COG0088	Forms part of the polypeptide exit tunnel
At12D13_RS08235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
At12D13_RS08240	COG0051	transcription antitermination factor activity, RNA binding
At12D13_RS08245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
At12D13_RS08250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
At12D13_RS08255	COG0049	tRNA binding
At12D13_RS08260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
At12D13_RS08285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
At12D13_RS08290	COG0085	RNA polymerase activity
At12D13_RS08295	COG0222	ribosome binding
At12D13_RS08300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
At12D13_RS08305	COG0081	regulation of translation
At12D13_RS08310	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
At12D13_RS08320	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
At12D13_RS08330	COG1086	Polysaccharide biosynthesis protein
At12D13_RS08335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
At12D13_RS08340	COG0861	Integral membrane protein TerC family
At12D13_RS08355	COG3895	Periplasmic Protein
At12D13_RS08380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
At12D13_RS08400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
At12D13_RS08435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS08435	COG2198	Histidine kinase
At12D13_RS08435	COG2205	protein histidine kinase activity
At12D13_RS08435	COG0784	Response regulator, receiver
At12D13_RS08440	COG0784	Response regulator, receiver
At12D13_RS08445	COG3920	Histidine kinase
At12D13_RS08445	COG2202	Pas domain
At12D13_RS08450	COG0784	Response regulator, receiver
At12D13_RS08455	COG4251	negative regulation of phosphorylation
At12D13_RS08475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
At12D13_RS08505	COG2910	NAD(P)H-binding
At12D13_RS08510	COG1733	regulation of RNA biosynthetic process
At12D13_RS08515	COG0556	nucleotide-excision repair
At12D13_RS08540	COG0484	heat shock protein binding
At12D13_RS08555	COG3706	GGDEF domain
At12D13_RS08565	COG3842	ATPase activity
At12D13_RS08575	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D13_RS08585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D13_RS08595	COG4115	mRNA cleavage
At12D13_RS08605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
At12D13_RS08615	COG2207	Transcriptional regulator
At12D13_RS08620	COG1064	alcohol dehydrogenase
At12D13_RS08625	COG1252	NADH dehydrogenase
At12D13_RS08630	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
At12D13_RS08635	COG2197	response regulator
At12D13_RS08640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
At12D13_RS08670	COG0656	L-ascorbic acid biosynthetic process
At12D13_RS08685	COG0440	acetolactate synthase activity
At12D13_RS08690	COG0028	Belongs to the TPP enzyme family
At12D13_RS08700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
At12D13_RS08705	COG0560	Phosphoserine phosphatase
At12D13_RS08705	COG3830	Belongs to the UPF0237 family
At12D13_RS08730	COG0330	HflC and HflK could
At12D13_RS08735	COG0330	HflC and HflK could
At12D13_RS08745	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
At12D13_RS08780	COG0277	FAD linked oxidase domain protein
At12D13_RS08785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
At12D13_RS08840	COG1335	isochorismatase
At12D13_RS08860	COG0006	proline dipeptidase activity
At12D13_RS08870	COG2264	protein methyltransferase activity
At12D13_RS08875	COG1999	signal sequence binding
At12D13_RS08885	COG0835	chemotaxis
At12D13_RS08895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
At12D13_RS08900	COG0583	DNA-binding transcription factor activity
At12D13_RS08920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
At12D13_RS08925	COG0497	DNA recombination
At12D13_RS08930	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
At12D13_RS08940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
At12D13_RS08945	COG0849	cell division
At12D13_RS08950	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
At12D13_RS08955	COG1181	Belongs to the D-alanine--D-alanine ligase family
At12D13_RS08960	COG0477	Major facilitator Superfamily
At12D13_RS08965	COG3300	MHYT domain
At12D13_RS08965	COG5001	Diguanylate cyclase
At12D13_RS08970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
At12D13_RS08975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
At12D13_RS08980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
At12D13_RS08990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
At12D13_RS08995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
At12D13_RS09005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
At12D13_RS09020	COG0275	rRNA processing
At12D13_RS09025	COG2001	Belongs to the MraZ family
At12D13_RS09035	COG3766	membrane
At12D13_RS09045	COG0754	glutathionylspermidine amidase activity
At12D13_RS09070	COG3023	N-Acetylmuramoyl-L-alanine amidase
At12D13_RS09100	COG4106	trans-aconitate 2-methyltransferase activity
At12D13_RS09120	COG2226	methyltransferase
At12D13_RS09130	COG2267	carboxylic ester hydrolase activity
At12D13_RS09135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
At12D13_RS09150	COG0251	oxidation-reduction process
At12D13_RS09165	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_RS09170	COG2814	Major facilitator Superfamily
At12D13_RS09195	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_RS09210	COG0174	glutamine synthetase
At12D13_RS09215	COG0531	amino acid
At12D13_RS09225	COG1737	Transcriptional regulator
At12D13_RS09250	COG3842	ATPase activity
At12D13_RS09415	COG2968	Membrane
At12D13_RS09425	COG0432	Pfam Uncharacterised protein family UPF0047
At12D13_RS09440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
At12D13_RS09445	COG0358	DNA primase activity
At12D13_RS09455	COG0505	Belongs to the CarA family
At12D13_RS09460	COG0534	Mate efflux family protein
At12D13_RS09475	COG2321	neutral zinc metallopeptidase
At12D13_RS09490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
At12D13_RS09500	COG3706	GGDEF domain
At12D13_RS09515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
At12D13_RS09525	COG1522	sequence-specific DNA binding
At12D13_RS09530	COG0492	ferredoxin-NADP+ reductase activity
At12D13_RS09535	COG0583	DNA-binding transcription factor activity
At12D13_RS09545	COG1902	pentaerythritol trinitrate reductase activity
At12D13_RS09575	COG0387	Pfam Sodium calcium exchanger
At12D13_RS09580	COG0436	Aminotransferase
At12D13_RS09585	COG2199	diguanylate cyclase activity
At12D13_RS09585	COG2200	EAL domain
At12D13_RS09605	COG1278	Cold shock
At12D13_RS09610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
At12D13_RS09625	COG1846	Transcriptional regulator
At12D13_RS09630	COG0745	RESPONSE REGULATOR receiver
At12D13_RS09635	COG2205	protein histidine kinase activity
At12D13_RS09640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
At12D13_RS09660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
At12D13_RS09670	COG1496	oxidoreductase activity
At12D13_RS09685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
At12D13_RS09695	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
At12D13_RS09710	COG0840	transmembrane signaling receptor activity
At12D13_RS09715	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_RS09720	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
At12D13_RS09725	COG3300	MHYT domain
At12D13_RS09725	COG5001	Diguanylate cyclase
At12D13_RS09730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
At12D13_RS09735	COG5001	Diguanylate cyclase
At12D13_RS09745	COG0193	aminoacyl-tRNA hydrolase activity
At12D13_RS09755	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
At12D13_RS09775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
At12D13_RS09780	COG2857	Cytochrome c1
At12D13_RS09780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
At12D13_RS09800	COG1132	(ABC) transporter
At12D13_RS09805	COG1132	(ABC) transporter
At12D13_RS09810	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
At12D13_RS09815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
At12D13_RS09830	COG0408	coproporphyrinogen oxidase activity
At12D13_RS09845	COG0617	tRNA 3'-terminal CCA addition
At12D13_RS09850	COG0494	nUDIX hydrolase
At12D13_RS09860	COG0714	Associated with various cellular activities
At12D13_RS09880	COG0454	-acetyltransferase
At12D13_RS09885	COG0477	Major facilitator Superfamily
At12D13_RS09895	COG0435	Glutathione S-transferase
At12D13_RS09915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
At12D13_RS09920	COG3135	benzoate transporter
At12D13_RS09935	COG1595	DNA-templated transcription, initiation
At12D13_RS09945	COG0740	serine-type endopeptidase activity
At12D13_RS09960	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
At12D13_RS09965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
At12D13_RS09990	COG4175	Glycine betaine
At12D13_RS10005	COG1435	thymidine kinase activity
At12D13_RS10025	COG2862	Uncharacterized protein family, UPF0114
At12D13_RS10040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
At12D13_RS10040	COG0512	Glutamine amidotransferase of anthranilate synthase
At12D13_RS10055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
At12D13_RS10070	COG0366	Alpha amylase catalytic
At12D13_RS10075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_RS10095	COG1160	GTP binding
At12D13_RS10115	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
At12D13_RS10125	COG0024	Methionine aminopeptidase
At12D13_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS10150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
At12D13_RS10160	COG0583	DNA-binding transcription factor activity
At12D13_RS10175	COG0402	S-adenosylhomocysteine deaminase activity
At12D13_RS10190	COG1304	FMN binding
At12D13_RS10200	COG1309	transcriptional regulator
At12D13_RS10205	COG1686	Belongs to the peptidase S11 family
At12D13_RS10215	COG2351	hydroxyisourate hydrolase activity
At12D13_RS10220	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
At12D13_RS10245	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
At12D13_RS10255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS10255	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
At12D13_RS10265	COG0513	Belongs to the DEAD box helicase family
At12D13_RS10270	COG0697	spore germination
At12D13_RS10275	COG2259	Doxx family
At12D13_RS10280	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_RS10290	COG2308	Evidence 4 Homologs of previously reported genes of
At12D13_RS10300	COG1305	Transglutaminase-like
At12D13_RS10305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
At12D13_RS10315	COG0456	acetyltransferase
At12D13_RS10330	COG4214	carbohydrate transport
At12D13_RS10335	COG1129	ABC transporter
At12D13_RS10340	COG4213	ABC transporter substrate-binding protein
At12D13_RS10385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
At12D13_RS10395	COG0840	transmembrane signaling receptor activity
At12D13_RS10400	COG2814	Major facilitator Superfamily
At12D13_RS10405	COG0646	methionine synthase
At12D13_RS10405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
At12D13_RS10415	COG4215	(ABC) transporter
At12D13_RS10420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS10455	COG1215	transferase activity, transferring glycosyl groups
At12D13_RS10490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
At12D13_RS10495	COG2346	COG2346, Truncated hemoglobins
At12D13_RS10515	COG1309	transcriptional regulator
At12D13_RS10530	COG0494	nUDIX hydrolase
At12D13_RS10545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_RS10550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_RS10585	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
At12D13_RS10595	COG0830	nickel cation binding
At12D13_RS10600	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
At12D13_RS10615	COG0804	urea catabolic process
At12D13_RS10620	COG1442	glycosyl transferase family 8
At12D13_RS10625	COG3755	Protein conserved in bacteria
At12D13_RS10635	COG0832	Belongs to the urease beta subunit family
At12D13_RS10640	COG3813	Protein conserved in bacteria
At12D13_RS10645	COG0831	urea catabolic process
At12D13_RS10650	COG0829	nickel cation binding
At12D13_RS10665	COG0411	ABC transporter
At12D13_RS10675	COG0559	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS10690	COG0174	glutamine synthetase
At12D13_RS10695	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS10700	COG0784	Response regulator, receiver
At12D13_RS10700	COG2198	Histidine kinase
At12D13_RS10700	COG5002	protein histidine kinase activity
At12D13_RS10750	COG1218	3'(2'),5'-bisphosphate nucleotidase
At12D13_RS10830	COG0564	pseudouridine synthase activity
At12D13_RS10840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
At12D13_RS10855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
At12D13_RS10885	COG0346	lactoylglutathione lyase activity
At12D13_RS10895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
At12D13_RS10905	COG2832	Protein of unknown function (DUF454)
At12D13_RS10910	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
At12D13_RS10915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_RS10920	COG4558	Periplasmic binding protein
At12D13_RS10930	COG3721	Heme iron utilization protein
At12D13_RS10950	COG2205	protein histidine kinase activity
At12D13_RS10990	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_RS10995	COG4605	iron ion homeostasis
At12D13_RS11000	COG4604	ABC transporter, ATP-binding protein
At12D13_RS11005	COG0783	Belongs to the Dps family
At12D13_RS11020	COG0583	DNA-binding transcription factor activity
At12D13_RS11025	COG0657	acetylesterase activity
At12D13_RS11030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_RS11050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
At12D13_RS11055	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
At12D13_RS11060	COG0288	reversible hydration of carbon dioxide
At12D13_RS11070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
At12D13_RS11090	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
At12D13_RS11095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
At12D13_RS11100	COG0778	Nitroreductase
At12D13_RS11105	COG2267	carboxylic ester hydrolase activity
At12D13_RS11110	COG0251	oxidation-reduction process
At12D13_RS11115	COG1335	isochorismatase
At12D13_RS11120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS11130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_RS11140	COG1653	transport
At12D13_RS11145	COG1175	transmembrane transport
At12D13_RS11150	COG0395	ABC-type sugar transport system, permease component
At12D13_RS11155	COG3842	ATPase activity
At12D13_RS11160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_RS11170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
At12D13_RS11185	COG4608	Belongs to the ABC transporter superfamily
At12D13_RS11190	COG0444	Belongs to the ABC transporter superfamily
At12D13_RS11195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS11200	COG0601	transmembrane transport
At12D13_RS11220	COG0392	lysyltransferase activity
At12D13_RS11220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
At12D13_RS11260	COG2159	amidohydrolase
At12D13_RS11265	COG1960	acyl-CoA dehydrogenase activity
At12D13_RS11295	COG0745	RESPONSE REGULATOR receiver
At12D13_RS11305	COG1902	pentaerythritol trinitrate reductase activity
At12D13_RS11305	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D13_RS11350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
At12D13_RS11360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_RS11365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
At12D13_RS11375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
At12D13_RS11385	COG1509	lysine 2,3-aminomutase activity
At12D13_RS11400	COG0583	DNA-binding transcription factor activity
At12D13_RS11405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS11410	COG0725	ABC transporter, periplasmic molybdate-binding protein
At12D13_RS11415	COG4149	molybdate abc transporter
At12D13_RS11420	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
At12D13_RS11430	COG3191	aminopeptidase activity
At12D13_RS11435	COG2022	thiamine diphosphate biosynthetic process
At12D13_RS11450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
At12D13_RS11455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
At12D13_RS11465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
At12D13_RS11490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
At12D13_RS11515	COG0438	transferase activity, transferring glycosyl groups
At12D13_RS11535	COG4166	transmembrane transport
At12D13_RS11540	COG0601	transmembrane transport
At12D13_RS11545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS11555	COG0438	transferase activity, transferring glycosyl groups
At12D13_RS11560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
At12D13_RS11565	COG3142	Participates in the control of copper homeostasis
At12D13_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS11590	COG1737	Transcriptional regulator
At12D13_RS11600	COG3842	ATPase activity
At12D13_RS11610	COG0395	ABC-type sugar transport system, permease component
At12D13_RS11615	COG1175	transmembrane transport
At12D13_RS11630	COG2188	Transcriptional regulator
At12D13_RS11635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
At12D13_RS11640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
At12D13_RS11645	COG1940	carbohydrate kinase activity
At12D13_RS11655	COG0671	phosphoesterase, PA-phosphatase related
At12D13_RS11660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
At12D13_RS11665	COG0156	8-amino-7-oxononanoate synthase activity
At12D13_RS11675	COG0729	surface antigen
At12D13_RS11685	COG0835	chemotaxis
At12D13_RS11695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
At12D13_RS11705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
At12D13_RS11710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
At12D13_RS11715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
At12D13_RS11720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
At12D13_RS11725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
At12D13_RS11740	COG4974	Belongs to the 'phage' integrase family
At12D13_RS11765	COG1280	lysine exporter protein (LysE YggA)
At12D13_RS11775	COG0508	dehydrogenase complex catalyzes the overall conversion of
At12D13_RS11785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
At12D13_RS11790	COG0045	succinate-CoA ligase (ADP-forming) activity
At12D13_RS11795	COG0039	L-malate dehydrogenase activity
At12D13_RS11800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
At12D13_RS11835	COG2264	protein methyltransferase activity
At12D13_RS11850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
At12D13_RS11855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
At12D13_RS11860	COG0181	hydroxymethylbilane synthase activity
At12D13_RS11895	COG1872	DUF167
At12D13_RS11900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
At12D13_RS11915	COG1217	gtp-binding protein TYPA
At12D13_RS11920	COG0339	signal peptide processing
At12D13_RS11925	COG1846	Transcriptional regulator
At12D13_RS11930	COG2814	Major facilitator Superfamily
At12D13_RS11935	COG0137	argininosuccinate synthase activity
At12D13_RS11945	COG1280	lysine exporter protein (LysE YggA)
At12D13_RS11950	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
At12D13_RS11955	COG4120	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS11965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
At12D13_RS11980	COG2154	pterin-4-alpha-carbinolamine dehydratase
At12D13_RS11985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
At12D13_RS11990	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
At12D13_RS12000	COG4181	ATPase activity
At12D13_RS12010	COG0670	Belongs to the BI1 family
At12D13_RS12025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
At12D13_RS12030	COG4133	protoheme IX ABC transporter activity
At12D13_RS12040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
At12D13_RS12045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
At12D13_RS12070	COG2917	probably involved in intracellular septation
At12D13_RS12075	COG0552	protein localization to endoplasmic reticulum
At12D13_RS12080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
At12D13_RS12085	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
At12D13_RS12100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
At12D13_RS12105	COG1605	Chorismate mutase
At12D13_RS12105	COG0287	Prephenate dehydrogenase
At12D13_RS12110	COG0228	four-way junction DNA binding
At12D13_RS12115	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
At12D13_RS12120	COG0336	Belongs to the RNA methyltransferase TrmD family
At12D13_RS12130	COG0335	large ribosomal subunit rRNA binding
At12D13_RS12140	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
At12D13_RS12145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_RS12165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
At12D13_RS12180	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
At12D13_RS12200	COG0488	(ABC) transporter
At12D13_RS12210	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
At12D13_RS12220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
At12D13_RS12225	COG0142	geranyltranstransferase activity
At12D13_RS12230	COG2885	chlorophyll binding
At12D13_RS12235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
At12D13_RS12240	COG2223	nitrite transmembrane transporter activity
At12D13_RS12245	COG1349	DNA-binding transcription factor activity
At12D13_RS12250	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
At12D13_RS12255	COG2197	response regulator
At12D13_RS12260	COG1132	(ABC) transporter
At12D13_RS12270	COG3459	Glycosyltransferase 36 associated
At12D13_RS12275	COG1473	amidohydrolase
At12D13_RS12285	COG0579	oxidoreductase
At12D13_RS12295	COG0129	dihydroxy-acid dehydratase activity
At12D13_RS12300	COG2084	Dehydrogenase
At12D13_RS12305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_RS12310	COG0277	FAD linked oxidase domain protein
At12D13_RS12315	COG2186	Transcriptional regulator
At12D13_RS12325	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
At12D13_RS12330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D13_RS12335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_RS12340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
At12D13_RS12350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
At12D13_RS12355	COG0495	leucyl-tRNA aminoacylation
At12D13_RS12370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
At12D13_RS12390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
At12D13_RS12395	COG1946	Acyl-CoA thioesterase
At12D13_RS12400	COG0347	Belongs to the P(II) protein family
At12D13_RS12405	COG0004	ammonium transporteR
At12D13_RS12410	COG1674	ftsk spoiiie
At12D13_RS12415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
At12D13_RS12430	COG0745	RESPONSE REGULATOR receiver
At12D13_RS12440	COG1329	Transcriptional regulator
At12D13_RS12445	COG2902	Dehydrogenase
At12D13_RS12450	COG2270	Major facilitator Superfamily
At12D13_RS12465	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS12480	COG0494	nUDIX hydrolase
At12D13_RS12490	COG0793	Belongs to the peptidase S41A family
At12D13_RS12500	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
At12D13_RS12505	COG0799	negative regulation of ribosome biogenesis
At12D13_RS12510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
At12D13_RS12515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
At12D13_RS12520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
At12D13_RS12525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
At12D13_RS12540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
At12D13_RS12545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
At12D13_RS12570	COG0066	3-isopropylmalate dehydratase activity
At12D13_RS12575	COG0473	3-isopropylmalate dehydrogenase activity
At12D13_RS12580	COG1858	cytochrome C peroxidase
At12D13_RS12585	COG1797	cobyrinic acid a,c-diamide synthase activity
At12D13_RS12590	COG1648	precorrin-2 dehydrogenase activity
At12D13_RS12590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
At12D13_RS12595	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
At12D13_RS12660	COG1492	cobalamin metabolic process
At12D13_RS12675	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_RS12680	COG3254	rhamnose metabolic process
At12D13_RS12685	COG0246	Mannitol dehydrogenase
At12D13_RS12690	COG1063	alcohol dehydrogenase
At12D13_RS12710	COG4214	carbohydrate transport
At12D13_RS12715	COG1129	ABC transporter
At12D13_RS12720	COG2186	Transcriptional regulator
At12D13_RS12725	COG2721	sulfolactate sulfo-lyase activity
At12D13_RS12730	COG0138	bifunctional purine biosynthesis protein purh
At12D13_RS12740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
At12D13_RS12740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
At12D13_RS12745	COG0501	Belongs to the peptidase M48B family
At12D13_RS12765	COG0357	Ribosomal RNA small subunit methyltransferase G
At12D13_RS12770	COG0445	tRNA wobble uridine modification
At12D13_RS12775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
At12D13_RS12780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
At12D13_RS12785	COG1981	membrane
At12D13_RS12790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
At12D13_RS12795	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
At12D13_RS12800	COG0424	maF-like protein
At12D13_RS12805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
At12D13_RS12810	COG0237	dephospho-CoA kinase activity
At12D13_RS12820	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
At12D13_RS12825	COG3030	protein affecting phage T7 exclusion by the F plasmid
At12D13_RS12835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
At12D13_RS12860	COG0179	Fumarylacetoacetate (FAA) hydrolase
At12D13_RS12875	COG0135	phosphoribosylanthranilate isomerase activity
At12D13_RS12880	COG0133	tryptophan synthase activity
At12D13_RS12885	COG0159	tryptophan synthase activity
At12D13_RS12890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
At12D13_RS12915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
At12D13_RS12925	COG2205	protein histidine kinase activity
At12D13_RS12935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
At12D13_RS12940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
At12D13_RS12945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
At12D13_RS12945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
At12D13_RS12950	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
At12D13_RS12955	COG0642	Histidine kinase
At12D13_RS12960	COG0745	RESPONSE REGULATOR receiver
At12D13_RS12965	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
At12D13_RS12975	COG1072	(Pantothenic acid kinase))
At12D13_RS12980	COG0140	phosphoribosyl-ATP diphosphatase activity
At12D13_RS12985	COG0107	imidazoleglycerol-phosphate synthase activity
At12D13_RS12990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
At12D13_RS12995	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
At12D13_RS13005	COG0131	Imidazoleglycerol-phosphate dehydratase
At12D13_RS13010	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
At12D13_RS13015	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
At12D13_RS13025	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
At12D13_RS13040	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
At12D13_RS13050	COG1643	Atp-dependent helicase
At12D13_RS13095	COG0514	ATP-dependent DNA helicase (RecQ)
At12D13_RS13120	COG1072	(Pantothenic acid kinase))
At12D13_RS13130	COG1780	Probably involved in ribonucleotide reductase function
At12D13_RS13150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
At12D13_RS13180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_RS13190	COG2813	Specifically methylates the guanine in position
At12D13_RS13195	COG1185	polyribonucleotide nucleotidyltransferase activity
At12D13_RS13200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
At12D13_RS13205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
At12D13_RS13210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
At12D13_RS13215	COG3064	Membrane
At12D13_RS13215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
At12D13_RS13230	COG0779	Required for maturation of 30S ribosomal subunits
At12D13_RS13235	COG2814	Major facilitator Superfamily
At12D13_RS13240	COG2951	lytic endotransglycosylase activity
At12D13_RS13245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
At12D13_RS13255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
At12D13_RS13260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
At12D13_RS13275	COG2816	NAD+ diphosphatase activity
At12D13_RS13280	COG0077	Prephenate dehydratase
At12D13_RS13280	COG1605	Chorismate mutase
At12D13_RS13285	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
At12D13_RS13290	COG3474	cytochrome
At12D13_RS13300	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
At12D13_RS13305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
At12D13_RS13315	COG1278	Cold shock
At12D13_RS13325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
At12D13_RS13340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
At12D13_RS13340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
At12D13_RS13350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
At12D13_RS13385	COG2900	Belongs to the SlyX family
At12D13_RS13395	COG0484	heat shock protein binding
At12D13_RS13400	COG0443	Heat shock 70 kDa protein
At12D13_RS13415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
At12D13_RS13420	COG1744	ABC transporter substrate-binding protein PnrA-like
At12D13_RS13425	COG3845	ABC transporter
At12D13_RS13430	COG1079	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS13435	COG1079	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS13440	COG0295	cytidine deaminase activity
At12D13_RS13445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
At12D13_RS13450	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
At12D13_RS13455	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
At12D13_RS13465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
At12D13_RS13470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
At12D13_RS13475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
At12D13_RS13485	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
At12D13_RS13490	COG1845	cytochrome c oxidase, subunit III
At12D13_RS13495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D13_RS13505	COG0477	Major facilitator Superfamily
At12D13_RS13515	COG0070	glutamate synthase
At12D13_RS13515	COG0069	glutamate synthase activity
At12D13_RS13515	COG0067	glutamate synthase
At12D13_RS13520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
At12D13_RS13535	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
At12D13_RS13545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
At12D13_RS13580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_RS13600	COG0848	biopolymer transport protein
At12D13_RS13610	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
At12D13_RS13630	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
At12D13_RS13635	COG3454	Phosphonate metabolism
At12D13_RS13640	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
At12D13_RS13645	COG3639	organic phosphonate transmembrane transporter activity
At12D13_RS13650	COG3639	organic phosphonate transmembrane transporter activity
At12D13_RS13655	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
At12D13_RS13660	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
At12D13_RS13670	COG4778	phosphonate C-P lyase system protein PhnL
At12D13_RS13675	COG4107	phosphonate C-P lyase system protein PhnK
At12D13_RS13680	COG3627	carbon phosphorus lyase activity
At12D13_RS13685	COG3626	phosphonate metabolism
At12D13_RS13690	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
At12D13_RS13695	COG3624	Phosphonate C-P lyase system protein PhnG
At12D13_RS13700	COG2188	Transcriptional regulator
At12D13_RS13705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
At12D13_RS13710	COG0837	glucose binding
At12D13_RS13715	COG1803	Methylglyoxal synthase
At12D13_RS13720	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
At12D13_RS13725	COG4166	transmembrane transport
At12D13_RS13730	COG4174	ABC transporter (Permease)
At12D13_RS13735	COG4239	(ABC) transporter, permease
At12D13_RS13740	COG4172	Belongs to the ABC transporter superfamily
At12D13_RS13745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS13750	COG0174	glutamine synthetase
At12D13_RS13755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS13760	COG3265	gluconokinase activity
At12D13_RS13765	COG1174	glycine betaine transport
At12D13_RS13770	COG1125	glycine betaine transport
At12D13_RS13775	COG1174	glycine betaine transport
At12D13_RS13780	COG1732	Glycine betaine
At12D13_RS13790	COG1959	2 iron, 2 sulfur cluster binding
At12D13_RS13795	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D13_RS13825	COG0697	spore germination
At12D13_RS13840	COG0791	NLP P60 protein
At12D13_RS13850	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
At12D13_RS13855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
At12D13_RS13890	COG4964	Belongs to the GSP D family
At12D13_RS13945	COG3422	double-strand break repair
At12D13_RS13950	COG3757	hydrolase, family 25
At12D13_RS13955	COG0697	spore germination
At12D13_RS13960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D13_RS13990	COG0481	GTPase activity
At12D13_RS13995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
At12D13_RS14010	COG1396	sequence-specific DNA binding
At12D13_RS14025	COG2169	Transcriptional regulator
At12D13_RS14025	COG1917	Cupin 2, conserved barrel domain protein
At12D13_RS14030	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
At12D13_RS14055	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
At12D13_RS14060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
At12D13_RS14065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
At12D13_RS14075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
At12D13_RS14080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
At12D13_RS14080	COG0072	phenylalanine-tRNA ligase activity
At12D13_RS14085	COG0667	Aldo Keto reductase
At12D13_RS14100	COG0667	Aldo Keto reductase
At12D13_RS14105	COG4977	sequence-specific DNA binding
At12D13_RS14130	COG1570	exodeoxyribonuclease VII activity
At12D13_RS14135	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_RS14145	COG1846	Transcriptional regulator
At12D13_RS14150	COG0697	spore germination
At12D13_RS14155	COG2309	aminopeptidase activity
At12D13_RS14160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
At12D13_RS14165	COG1393	Belongs to the ArsC family
At12D13_RS14180	COG1309	transcriptional regulator
At12D13_RS14190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
At12D13_RS14190	COG0519	Catalyzes the synthesis of GMP from XMP
At12D13_RS14205	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
At12D13_RS14235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
At12D13_RS14245	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
At12D13_RS14255	COG1968	undecaprenyl-diphosphatase activity
At12D13_RS14275	COG0284	orotidine-5'-phosphate decarboxylase activity
At12D13_RS14285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
At12D13_RS14295	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
At12D13_RS14300	COG0792	nuclease activity
At12D13_RS14315	COG1175	transmembrane transport
At12D13_RS14320	COG0395	ABC-type sugar transport system, permease component
At12D13_RS14325	COG3842	ATPase activity
At12D13_RS14335	COG0189	ligase activity
At12D13_RS14340	COG0606	chelatase, subunit chli
At12D13_RS14345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
At12D13_RS14350	COG1280	lysine exporter protein (LysE YggA)
At12D13_RS14355	COG0756	dUTP diphosphatase activity
At12D13_RS14360	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
At12D13_RS14365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
At12D13_RS14380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
At12D13_RS14385	COG2226	methyltransferase
At12D13_RS14390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
At12D13_RS14395	COG1024	Enoyl-CoA hydratase
At12D13_RS14400	COG0268	Binds directly to 16S ribosomal RNA
At12D13_RS14445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
At12D13_RS14455	COG0640	Transcriptional regulator
At12D13_RS14500	COG3842	ATPase activity
At12D13_RS14505	COG4209	transmembrane transport
At12D13_RS14510	COG0395	ABC-type sugar transport system, permease component
At12D13_RS14515	COG1653	transport
At12D13_RS14525	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS14535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_RS14545	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_RS14575	COG2197	response regulator
At12D13_RS14580	COG0601	transmembrane transport
At12D13_RS14585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS14605	COG0747	negative chemotaxis
At12D13_RS14620	COG1446	asparaginase
At12D13_RS14630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS14635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS14640	COG0601	transmembrane transport
At12D13_RS14680	COG1215	transferase activity, transferring glycosyl groups
At12D13_RS14690	COG0025	NhaP-type Na H and K H
At12D13_RS14695	COG4178	(ABC) transporter
At12D13_RS14705	COG1609	Transcriptional regulator
At12D13_RS14720	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS14725	COG1735	metal-dependent hydrolase with the TIM-barrel fold
At12D13_RS14760	COG1794	racemase activity, acting on amino acids and derivatives
At12D13_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS14770	COG1309	transcriptional regulator
At12D13_RS14775	COG2233	PERMEase
At12D13_RS14815	COG1595	DNA-templated transcription, initiation
At12D13_RS14825	COG0395	ABC-type sugar transport system, permease component
At12D13_RS14830	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D13_RS14840	COG3842	ATPase activity
At12D13_RS14875	COG1653	transport
At12D13_RS14885	COG0395	ABC-type sugar transport system, permease component
At12D13_RS14890	COG3842	ATPase activity
At12D13_RS14895	COG0395	ABC-type sugar transport system, permease component
At12D13_RS14900	COG1175	transmembrane transport
At12D13_RS14930	COG1609	Transcriptional regulator
At12D13_RS14940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_RS14945	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_RS14950	COG3842	ATPase activity
At12D13_RS14955	COG0395	ABC-type sugar transport system, permease component
At12D13_RS14960	COG1175	transmembrane transport
At12D13_RS14965	COG1653	transport
At12D13_RS14970	COG1309	transcriptional regulator
At12D13_RS14975	COG0673	inositol 2-dehydrogenase activity
At12D13_RS14990	COG0673	inositol 2-dehydrogenase activity
At12D13_RS15000	COG1278	Cold shock
At12D13_RS15010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
At12D13_RS15030	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
At12D13_RS15045	COG3842	ATPase activity
At12D13_RS15050	COG0395	ABC-type sugar transport system, permease component
At12D13_RS15055	COG1175	transmembrane transport
At12D13_RS15075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_RS15080	COG3618	amidohydrolase
At12D13_RS15085	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_RS15090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_RS15095	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS15100	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
At12D13_RS15105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_RS15110	COG2186	Transcriptional regulator
At12D13_RS15165	COG2223	nitrite transmembrane transporter activity
At12D13_RS15170	COG0583	DNA-binding transcription factor activity
At12D13_RS15175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D13_RS15185	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_RS15190	COG2084	Dehydrogenase
At12D13_RS15205	COG1609	Transcriptional regulator
At12D13_RS15210	COG1063	alcohol dehydrogenase
At12D13_RS15215	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS15230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_RS15235	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
At12D13_RS15240	COG1175	transmembrane transport
At12D13_RS15245	COG0395	ABC-type sugar transport system, permease component
At12D13_RS15260	COG0395	ABC-type sugar transport system, permease component
At12D13_RS15265	COG1175	transmembrane transport
At12D13_RS15270	COG2182	Extracellular solute-binding protein
At12D13_RS15275	COG0626	cystathionine gamma-synthase activity
At12D13_RS15285	COG0328	RNA-DNA hybrid ribonuclease activity
At12D13_RS15290	COG0803	Belongs to the bacterial solute-binding protein 9 family
At12D13_RS15300	COG1121	(ABC) transporter
At12D13_RS15305	COG0523	cobalamin synthesis protein
At12D13_RS15320	COG0523	cobalamin synthesis protein
At12D13_RS15325	COG1653	transport
At12D13_RS15330	COG1175	transmembrane transport
At12D13_RS15335	COG0395	ABC-type sugar transport system, permease component
At12D13_RS15340	COG3842	ATPase activity
At12D13_RS15355	COG3047	cAMP biosynthetic process
At12D13_RS15380	COG0583	DNA-binding transcription factor activity
At12D13_RS15385	COG1879	ABC-type sugar transport system periplasmic component
At12D13_RS15390	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS15395	COG1129	ABC transporter
At12D13_RS15405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
At12D13_RS15410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_RS15420	COG3257	ureidoglycine aminohydrolase activity
At12D13_RS15430	COG5001	Diguanylate cyclase
At12D13_RS15435	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
At12D13_RS15445	COG0747	negative chemotaxis
At12D13_RS15450	COG0601	transmembrane transport
At12D13_RS15455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS15465	COG4608	Belongs to the ABC transporter superfamily
At12D13_RS15485	COG0129	dihydroxy-acid dehydratase activity
At12D13_RS15495	COG1879	ABC-type sugar transport system periplasmic component
At12D13_RS15500	COG1129	ABC transporter
At12D13_RS15505	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS15510	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS15515	COG2186	Transcriptional regulator
At12D13_RS15530	COG0587	DNA-directed DNA polymerase activity
At12D13_RS15560	COG0673	inositol 2-dehydrogenase activity
At12D13_RS15570	COG3842	ATPase activity
At12D13_RS15575	COG0395	ABC-type sugar transport system, permease component
At12D13_RS15580	COG1175	transmembrane transport
At12D13_RS15585	COG1653	transport
At12D13_RS15595	COG0673	inositol 2-dehydrogenase activity
At12D13_RS15610	COG3300	MHYT domain
At12D13_RS15610	COG5001	Diguanylate cyclase
At12D13_RS15615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS15625	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
At12D13_RS15630	COG2894	cell division
At12D13_RS15635	COG0850	regulation of cytokinetic process
At12D13_RS15645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
At12D13_RS15650	COG2186	Transcriptional regulator
At12D13_RS15655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_RS15665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D13_RS15670	COG1063	alcohol dehydrogenase
At12D13_RS15675	COG1312	Catalyzes the dehydration of D-mannonate
At12D13_RS15690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_RS15695	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D13_RS15695	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
At12D13_RS15700	COG4172	Belongs to the ABC transporter superfamily
At12D13_RS15705	COG1921	L-seryl-tRNASec selenium transferase activity
At12D13_RS15720	COG3964	amidohydrolase
At12D13_RS15730	COG0601	transmembrane transport
At12D13_RS15740	COG0747	negative chemotaxis
At12D13_RS15750	COG0438	transferase activity, transferring glycosyl groups
At12D13_RS15785	COG4989	oxidoreductase activity
At12D13_RS15800	COG3842	ATPase activity
At12D13_RS15805	COG1653	transport
At12D13_RS15810	COG1175	transmembrane transport
At12D13_RS15815	COG0395	ABC-type sugar transport system, permease component
At12D13_RS15820	COG1501	Belongs to the glycosyl hydrolase 31 family
At12D13_RS15825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_RS15830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D13_RS15835	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
At12D13_RS15840	COG0352	thiamine-phosphate diphosphorylase activity
At12D13_RS15845	COG0351	phosphomethylpyrimidine kinase
At12D13_RS15855	COG1522	sequence-specific DNA binding
At12D13_RS15860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
At12D13_RS15865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS15880	COG2204	response regulator
At12D13_RS15910	COG2942	2-epimerase
At12D13_RS15945	COG2197	response regulator
At12D13_RS15980	COG3307	-O-antigen
At12D13_RS15985	COG1596	polysaccharide export
At12D13_RS15995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
At12D13_RS16010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
At12D13_RS16015	COG0840	transmembrane signaling receptor activity
At12D13_RS16015	COG2972	Histidine kinase
At12D13_RS16020	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_RS16020	COG1388	LysM domain
At12D13_RS16030	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS16040	COG2094	Belongs to the DNA glycosylase MPG family
At12D13_RS16055	COG1609	Transcriptional regulator
At12D13_RS16060	COG1653	transport
At12D13_RS16075	COG3842	ATPase activity
At12D13_RS16085	COG0673	inositol 2-dehydrogenase activity
At12D13_RS16090	COG0602	queuosine metabolic process
At12D13_RS16095	COG0720	synthase
At12D13_RS16100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
At12D13_RS16105	COG0673	inositol 2-dehydrogenase activity
At12D13_RS16120	COG0395	ABC-type sugar transport system, permease component
At12D13_RS16125	COG1175	transmembrane transport
At12D13_RS16145	COG0583	DNA-binding transcription factor activity
At12D13_RS16150	COG0281	malic enzyme
At12D13_RS16150	COG0280	phosphate acetyltransferase
At12D13_RS16165	COG0765	amino acid transport
At12D13_RS16175	COG2079	MmgE PrpD family protein
At12D13_RS16180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS16190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS16210	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
At12D13_RS16215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D13_RS16220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
At12D13_RS16225	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
At12D13_RS16230	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS16235	COG1129	ABC transporter
At12D13_RS16250	COG1473	amidohydrolase
At12D13_RS16270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS16275	COG0601	transmembrane transport
At12D13_RS16280	COG0583	DNA-binding transcription factor activity
At12D13_RS16285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_RS16290	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
At12D13_RS16310	COG1595	DNA-templated transcription, initiation
At12D13_RS16315	COG1120	ATPase activity
At12D13_RS16320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_RS16335	COG2226	methyltransferase
At12D13_RS16345	COG1120	ATPase activity
At12D13_RS16350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_RS16370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D13_RS16380	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_RS16385	COG0473	3-isopropylmalate dehydrogenase activity
At12D13_RS16390	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_RS16395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS16425	COG0601	transmembrane transport
At12D13_RS16430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS16435	COG4172	Belongs to the ABC transporter superfamily
At12D13_RS16440	COG1522	sequence-specific DNA binding
At12D13_RS16445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS16455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS16460	COG1126	abc transporter atp-binding protein
At12D13_RS16470	COG1473	amidohydrolase
At12D13_RS16475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS16480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS16485	COG1959	2 iron, 2 sulfur cluster binding
At12D13_RS16495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
At12D13_RS16500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS16520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS16525	COG1960	acyl-CoA dehydrogenase activity
At12D13_RS16560	COG0667	Aldo Keto reductase
At12D13_RS16570	COG0583	DNA-binding transcription factor activity
At12D13_RS16575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS16590	COG0747	negative chemotaxis
At12D13_RS16595	COG1473	amidohydrolase
At12D13_RS16600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS16615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS16620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS16640	COG4608	Belongs to the ABC transporter superfamily
At12D13_RS16645	COG0444	Belongs to the ABC transporter superfamily
At12D13_RS16655	COG0601	transmembrane transport
At12D13_RS16665	COG2186	Transcriptional regulator
At12D13_RS16690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
At12D13_RS16690	COG3453	Protein conserved in bacteria
At12D13_RS16695	COG0640	Transcriptional regulator
At12D13_RS16705	COG2391	methyltransferase activity
At12D13_RS16710	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
At12D13_RS16725	COG0022	dehydrogenase e1 component
At12D13_RS16735	COG1960	acyl-CoA dehydrogenase activity
At12D13_RS16740	COG0183	Belongs to the thiolase family
At12D13_RS16750	COG1960	acyl-CoA dehydrogenase activity
At12D13_RS16755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
At12D13_RS16770	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
At12D13_RS16775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
At12D13_RS16780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
At12D13_RS16785	COG4952	isomerase
At12D13_RS16790	COG3347	Dehydrogenase
At12D13_RS16790	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS16795	COG1349	DNA-binding transcription factor activity
At12D13_RS16810	COG1129	ABC transporter
At12D13_RS16815	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS16825	COG3254	rhamnose metabolic process
At12D13_RS16840	COG2264	protein methyltransferase activity
At12D13_RS16845	COG5001	Diguanylate cyclase
At12D13_RS16865	COG4335	DNA alkylation repair
At12D13_RS16870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
At12D13_RS16875	COG4208	sulfate ABC transporter
At12D13_RS16885	COG4150	thiosulfate binding
At12D13_RS16905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
At12D13_RS16915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
At12D13_RS16925	COG1040	competence protein
At12D13_RS16930	COG2226	methyltransferase
At12D13_RS16945	COG0494	nUDIX hydrolase
At12D13_RS16955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
At12D13_RS16960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
At12D13_RS16965	COG0653	protein targeting
At12D13_RS16970	COG0697	spore germination
At12D13_RS17010	COG1312	Catalyzes the dehydration of D-mannonate
At12D13_RS17015	COG0246	Mannitol dehydrogenase
At12D13_RS17035	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS17045	COG1129	ABC transporter
At12D13_RS17080	COG2376	Dihydroxyacetone kinase
At12D13_RS17085	COG3273	potassium ion transport
At12D13_RS17085	COG0471	metal ion transport
At12D13_RS17105	COG0438	transferase activity, transferring glycosyl groups
At12D13_RS17115	COG2244	polysaccharide biosynthetic process
At12D13_RS17145	COG0489	protein tyrosine kinase activity
At12D13_RS17145	COG3206	protein involved in exopolysaccharide biosynthesis
At12D13_RS17165	COG0438	transferase activity, transferring glycosyl groups
At12D13_RS17185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
At12D13_RS17190	COG2273	Hydrolase Family 16
At12D13_RS17190	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
At12D13_RS17235	COG1396	sequence-specific DNA binding
At12D13_RS17245	COG1129	ABC transporter
At12D13_RS17250	COG4214	carbohydrate transport
At12D13_RS17255	COG4213	ABC transporter substrate-binding protein
At12D13_RS17270	COG0346	lactoylglutathione lyase activity
At12D13_RS17275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
At12D13_RS17275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
At12D13_RS17280	COG4770	biotin carboxylase activity
At12D13_RS17290	COG0625	glutathione transferase activity
At12D13_RS17295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
At12D13_RS17300	COG3800	Transcriptional regulator
At12D13_RS17300	COG1396	sequence-specific DNA binding
At12D13_RS17310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
At12D13_RS17320	COG0300	oxidoreductase activity
At12D13_RS17340	COG2086	electron transfer activity
At12D13_RS17350	COG1250	3-hydroxyacyl-CoA dehydrogenase
At12D13_RS17355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
At12D13_RS17360	COG0165	Argininosuccinate lyase
At12D13_RS17395	COG2884	Cell division ATP-binding protein ftsE
At12D13_RS17415	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
At12D13_RS17430	COG0287	Prephenate dehydrogenase
At12D13_RS17435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
At12D13_RS17440	COG2226	methyltransferase
At12D13_RS17445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
At12D13_RS17460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
At12D13_RS17465	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
At12D13_RS17495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
At12D13_RS17500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
At12D13_RS17515	COG4974	Belongs to the 'phage' integrase family
At12D13_RS17520	COG0825	malonyl-CoA metabolic process
At12D13_RS17525	COG3034	peptidoglycan biosynthetic process
At12D13_RS17530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
At12D13_RS17530	COG0425	Belongs to the sulfur carrier protein TusA family
At12D13_RS17540	COG0523	cobalamin synthesis protein
At12D13_RS17545	COG1686	Belongs to the peptidase S11 family
At12D13_RS17550	COG1473	amidohydrolase
At12D13_RS17560	COG1959	2 iron, 2 sulfur cluster binding
At12D13_RS17565	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
At12D13_RS17575	COG0534	Mate efflux family protein
At12D13_RS17610	COG2226	methyltransferase
At12D13_RS17645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
At12D13_RS17665	COG4774	siderophore transport
At12D13_RS17665	COG1629	transport
At12D13_RS17670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
At12D13_RS17675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_RS17680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_RS17685	COG1120	ATPase activity
At12D13_RS17700	COG4953	penicillin-binding protein 1C
At12D13_RS17705	COG2373	Large extracellular alpha-helical protein
At12D13_RS17710	COG2835	tetraacyldisaccharide 4'-kinase activity
At12D13_RS17720	COG3118	belongs to the thioredoxin family
At12D13_RS17735	COG0625	glutathione transferase activity
At12D13_RS17745	COG0482	sulfurtransferase activity
At12D13_RS17760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D13_RS17775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
At12D13_RS17780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
At12D13_RS17785	COG0037	tRNA processing
At12D13_RS17795	COG2885	chlorophyll binding
At12D13_RS17800	COG0823	Involved in the tonB-independent uptake of proteins
At12D13_RS17820	COG0824	Thioesterase
At12D13_RS17830	COG0494	nUDIX hydrolase
At12D13_RS17845	COG2255	four-way junction helicase activity
At12D13_RS17850	COG0632	four-way junction helicase activity
At12D13_RS17855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
At12D13_RS17860	COG0840	transmembrane signaling receptor activity
At12D13_RS17865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS17870	COG0217	transcriptional regulatory protein
At12D13_RS17885	COG1692	metallophosphoesterase
At12D13_RS17895	COG1253	flavin adenine dinucleotide binding
At12D13_RS17935	COG0126	phosphoglycerate kinase activity
At12D13_RS17940	COG3588	fructose-bisphosphate aldolase
At12D13_RS17960	COG0254	rRNA binding
At12D13_RS17965	COG1132	(ABC) transporter
At12D13_RS17990	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_RS18020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
At12D13_RS18025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
At12D13_RS18030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
At12D13_RS18035	COG0457	Tetratricopeptide repeat
At12D13_RS18040	COG3750	Belongs to the UPF0335 family
At12D13_RS18060	COG0469	pyruvate kinase activity
At12D13_RS18065	COG3108	Peptidase M15
At12D13_RS18070	COG2204	response regulator
At12D13_RS18075	COG1164	Oligoendopeptidase f
At12D13_RS18080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
At12D13_RS18090	COG5310	Homospermidine synthase
At12D13_RS18100	COG0737	Belongs to the 5'-nucleotidase family
At12D13_RS18105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
At12D13_RS18110	COG0330	HflC and HflK could
At12D13_RS18140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
At12D13_RS18145	COG2951	lytic endotransglycosylase activity
At12D13_RS18160	COG2205	protein histidine kinase activity
At12D13_RS18170	COG0069	glutamate synthase activity
At12D13_RS18170	COG0067	glutamate synthase
At12D13_RS18170	COG0070	glutamate synthase
At12D13_RS18180	COG0745	RESPONSE REGULATOR receiver
At12D13_RS18185	COG2205	protein histidine kinase activity
At12D13_RS18190	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
At12D13_RS18195	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
At12D13_RS18200	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
At12D13_RS18210	COG0252	asparaginase activity
At12D13_RS18220	COG1027	Aspartate ammonia-lyase
At12D13_RS18225	COG2186	Transcriptional regulator
At12D13_RS18260	COG4176	ABC-type proline glycine betaine transport system permease component
At12D13_RS18265	COG0517	IMP dehydrogenase activity
At12D13_RS18265	COG4175	Glycine betaine
At12D13_RS18270	COG2986	histidine ammonia-lyase
At12D13_RS18275	COG2814	Major facilitator Superfamily
At12D13_RS18290	COG1522	sequence-specific DNA binding
At12D13_RS18295	COG0583	DNA-binding transcription factor activity
At12D13_RS18300	COG0667	Aldo Keto reductase
At12D13_RS18310	COG1335	isochorismatase
At12D13_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS18325	COG3254	rhamnose metabolic process
At12D13_RS18340	COG2721	sulfolactate sulfo-lyase activity
At12D13_RS18345	COG1129	ABC transporter
At12D13_RS18355	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS18360	COG1879	ABC-type sugar transport system periplasmic component
At12D13_RS18395	COG0583	DNA-binding transcription factor activity
At12D13_RS18435	COG2307	Protein conserved in bacteria
At12D13_RS18435	COG2308	Evidence 4 Homologs of previously reported genes of
At12D13_RS18450	COG0488	(ABC) transporter
At12D13_RS18455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_RS18460	COG1304	FMN binding
At12D13_RS18470	COG1846	Transcriptional regulator
At12D13_RS18480	COG1070	Carbohydrate kinase
At12D13_RS18485	COG1830	Aldolase
At12D13_RS18490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
At12D13_RS18495	COG0667	Aldo Keto reductase
At12D13_RS18505	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS18510	COG1129	ABC transporter
At12D13_RS18515	COG1879	ABC-type sugar transport system periplasmic component
At12D13_RS18550	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D13_RS18565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
At12D13_RS18580	COG0395	ABC-type sugar transport system, permease component
At12D13_RS18595	COG3842	ATPase activity
At12D13_RS18610	COG1648	precorrin-2 dehydrogenase activity
At12D13_RS18610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
At12D13_RS18615	COG0243	molybdopterin cofactor binding
At12D13_RS18630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
At12D13_RS18635	COG1116	anion transmembrane transporter activity
At12D13_RS18640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_RS18645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D13_RS18655	COG3707	response regulator
At12D13_RS18660	COG1802	Transcriptional regulator
At12D13_RS18665	COG1914	H( )-stimulated, divalent metal cation uptake system
At12D13_RS18670	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
At12D13_RS18675	COG4336	lyase activity
At12D13_RS18680	COG1984	allophanate hydrolase subunit 2
At12D13_RS18685	COG4770	biotin carboxylase activity
At12D13_RS18690	COG0366	Alpha amylase catalytic
At12D13_RS18700	COG4771	TonB-dependent receptor
At12D13_RS18705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
At12D13_RS18730	COG1414	Transcriptional regulator
At12D13_RS18735	COG1475	DNA binding
At12D13_RS18740	COG1192	Involved in chromosome partitioning
At12D13_RS18775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
At12D13_RS18790	COG2986	histidine ammonia-lyase
At12D13_RS18795	COG1228	amidohydrolase
At12D13_RS18800	COG0402	S-adenosylhomocysteine deaminase activity
At12D13_RS18860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS18870	COG2423	ornithine cyclodeaminase activity
At12D13_RS18885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS18890	COG3938	Belongs to the proline racemase family
At12D13_RS18895	COG4176	ABC-type proline glycine betaine transport system permease component
At12D13_RS18905	COG4175	Glycine betaine
At12D13_RS18905	COG3448	diguanylate cyclase activity
At12D13_RS18915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS18920	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_RS18925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_RS18955	COG0673	inositol 2-dehydrogenase activity
At12D13_RS18960	COG0673	inositol 2-dehydrogenase activity
At12D13_RS18970	COG1175	transmembrane transport
At12D13_RS18975	COG0395	ABC-type sugar transport system, permease component
At12D13_RS18980	COG3842	ATPase activity
At12D13_RS18990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_RS18995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
At12D13_RS19020	COG0583	DNA-binding transcription factor activity
At12D13_RS19025	COG0346	lactoylglutathione lyase activity
At12D13_RS19040	COG1574	metal-dependent hydrolase with the TIM-barrel fold
At12D13_RS19050	COG2814	Major facilitator Superfamily
At12D13_RS19065	COG0583	DNA-binding transcription factor activity
At12D13_RS19070	COG0477	Major facilitator Superfamily
At12D13_RS19125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
At12D13_RS19135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
At12D13_RS19140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
At12D13_RS19145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
At12D13_RS19175	COG0010	Belongs to the arginase family
At12D13_RS19185	COG0697	spore germination
At12D13_RS19190	COG0673	inositol 2-dehydrogenase activity
At12D13_RS19215	COG0477	Major facilitator Superfamily
At12D13_RS19220	COG0642	Histidine kinase
At12D13_RS19230	COG2194	sulfuric ester hydrolase activity
At12D13_RS19240	COG0583	DNA-binding transcription factor activity
At12D13_RS19245	COG4774	siderophore transport
At12D13_RS19260	COG1120	ATPase activity
At12D13_RS19270	COG3474	cytochrome
At12D13_RS19275	COG2137	regulation of response to DNA damage stimulus
At12D13_RS19280	COG3386	PFAM SMP-30 Gluconolaconase
At12D13_RS19290	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS19295	COG1129	ABC transporter
At12D13_RS19300	COG1879	ABC-type sugar transport system periplasmic component
At12D13_RS19310	COG4585	Histidine kinase
At12D13_RS19315	COG2197	response regulator
At12D13_RS19325	COG2133	pyrroloquinoline quinone binding
At12D13_RS19335	COG0500	methyltransferase
At12D13_RS19340	COG0564	pseudouridine synthase activity
At12D13_RS19355	COG0517	IMP dehydrogenase activity
At12D13_RS19355	COG4175	Glycine betaine
At12D13_RS19360	COG4176	ABC-type proline glycine betaine transport system permease component
At12D13_RS19370	COG0784	Response regulator, receiver
At12D13_RS19370	COG4191	Histidine kinase
At12D13_RS19375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D13_RS19380	COG3206	protein involved in exopolysaccharide biosynthesis
At12D13_RS19380	COG0489	protein tyrosine kinase activity
At12D13_RS19385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
At12D13_RS19390	COG1215	transferase activity, transferring glycosyl groups
At12D13_RS19395	COG1215	transferase activity, transferring glycosyl groups
At12D13_RS19405	COG2273	Hydrolase Family 16
At12D13_RS19410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
At12D13_RS19415	COG2244	polysaccharide biosynthetic process
At12D13_RS19420	COG0463	Glycosyl transferase, family 2
At12D13_RS19425	COG2327	Polysaccharide pyruvyl transferase
At12D13_RS19430	COG1215	transferase activity, transferring glycosyl groups
At12D13_RS19450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
At12D13_RS19460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS19475	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D13_RS19475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D13_RS19500	COG0033	Phosphoglucomutase
At12D13_RS19505	COG0297	glycogen (starch) synthase activity
At12D13_RS19510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
At12D13_RS19515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
At12D13_RS19520	COG0058	SHG alpha-glucan phosphorylase activity
At12D13_RS19535	COG1794	racemase activity, acting on amino acids and derivatives
At12D13_RS19540	COG1522	sequence-specific DNA binding
At12D13_RS19550	COG2084	Dehydrogenase
At12D13_RS19555	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS19560	COG1063	alcohol dehydrogenase
At12D13_RS19570	COG4988	ABC transporter
At12D13_RS19575	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
At12D13_RS19585	COG1294	oxidase, subunit
At12D13_RS19615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
At12D13_RS19620	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
At12D13_RS19650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
At12D13_RS19655	COG0539	negative regulation of cytoplasmic translation
At12D13_RS19685	COG4221	oxidoreductase activity
At12D13_RS19695	COG0006	proline dipeptidase activity
At12D13_RS19700	COG0747	negative chemotaxis
At12D13_RS19705	COG0601	transmembrane transport
At12D13_RS19710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS19715	COG0444	Belongs to the ABC transporter superfamily
At12D13_RS19720	COG4608	Belongs to the ABC transporter superfamily
At12D13_RS19735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS19760	COG0559	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS19780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
At12D13_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS19805	COG4993	Dehydrogenase
At12D13_RS19810	COG3685	Protein conserved in bacteria
At12D13_RS19840	COG0693	protein deglycase activity
At12D13_RS19865	COG0189	ligase activity
At12D13_RS19870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_RS19875	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
At12D13_RS19885	COG0583	DNA-binding transcription factor activity
At12D13_RS19890	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_RS19895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D13_RS19900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_RS19905	COG1116	anion transmembrane transporter activity
At12D13_RS19920	COG1522	sequence-specific DNA binding
At12D13_RS19935	COG0784	Response regulator, receiver
At12D13_RS19945	COG3920	Histidine kinase
At12D13_RS19955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
At12D13_RS19970	COG0019	diaminopimelate decarboxylase activity
At12D13_RS19980	COG0513	Belongs to the DEAD box helicase family
At12D13_RS19990	COG0527	aspartate kinase activity
At12D13_RS20000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
At12D13_RS20005	COG2890	protein-(glutamine-N5) methyltransferase activity
At12D13_RS20015	COG0542	response to heat
At12D13_RS20020	COG1196	nuclear chromosome segregation
At12D13_RS20020	COG0741	lytic transglycosylase activity
At12D13_RS20020	COG0739	heme binding
At12D13_RS20065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_RS20075	COG2186	Transcriptional regulator
At12D13_RS20080	COG0747	negative chemotaxis
At12D13_RS20085	COG0601	transmembrane transport
At12D13_RS20090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS20095	COG4172	Belongs to the ABC transporter superfamily
At12D13_RS20100	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_RS20125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
At12D13_RS20135	COG0439	Biotin carboxylase
At12D13_RS20145	COG1984	allophanate hydrolase subunit 2
At12D13_RS20155	COG3842	ATPase activity
At12D13_RS20160	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D13_RS20175	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS20185	COG3842	ATPase activity
At12D13_RS20190	COG0726	polysaccharide deacetylase
At12D13_RS20200	COG0523	cobalamin synthesis protein
At12D13_RS20240	COG1881	PFAM PEBP family protein
At12D13_RS20280	COG1278	Cold shock
At12D13_RS20295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
At12D13_RS20315	COG0300	oxidoreductase activity
At12D13_RS20325	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D13_RS20325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D13_RS20330	COG4311	Sarcosine oxidase, delta subunit
At12D13_RS20335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS20340	COG4977	sequence-specific DNA binding
At12D13_RS20350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
At12D13_RS20355	COG2218	PFAM glutamate synthase alpha subunit domain protein
At12D13_RS20360	COG0069	glutamate synthase activity
At12D13_RS20365	COG0174	glutamine synthetase
At12D13_RS20385	COG0765	amino acid transport
At12D13_RS20390	COG1126	abc transporter atp-binding protein
At12D13_RS20395	COG1454	alcohol dehydrogenase
At12D13_RS20405	COG2267	carboxylic ester hydrolase activity
At12D13_RS20415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_RS20420	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_RS20440	COG1177	transmembrane transport
At12D13_RS20445	COG3842	ATPase activity
At12D13_RS20460	COG3842	ATPase activity
At12D13_RS20465	COG0395	ABC-type sugar transport system, permease component
At12D13_RS20470	COG1175	transmembrane transport
At12D13_RS20480	COG3976	FMN-binding domain protein
At12D13_RS20480	COG1053	succinate dehydrogenase
At12D13_RS20485	COG1609	Transcriptional regulator
At12D13_RS20495	COG4172	Belongs to the ABC transporter superfamily
At12D13_RS20500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS20505	COG0601	transmembrane transport
At12D13_RS20515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_RS20530	COG2828	Protein conserved in bacteria
At12D13_RS20535	COG0583	DNA-binding transcription factor activity
At12D13_RS20545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D13_RS20555	COG1280	lysine exporter protein (LysE YggA)
At12D13_RS20570	COG0583	DNA-binding transcription factor activity
At12D13_RS20580	COG0511	ligase activity, forming carbon-carbon bonds
At12D13_RS20585	COG0439	Biotin carboxylase
At12D13_RS20600	COG1984	allophanate hydrolase subunit 2
At12D13_RS20605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
At12D13_RS20610	COG0436	Aminotransferase
At12D13_RS20620	COG4221	oxidoreductase activity
At12D13_RS20625	COG0765	amino acid transport
At12D13_RS20630	COG0765	amino acid transport
At12D13_RS20635	COG1126	abc transporter atp-binding protein
At12D13_RS20640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS20645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
At12D13_RS20660	COG0583	DNA-binding transcription factor activity
At12D13_RS20670	COG0583	DNA-binding transcription factor activity
At12D13_RS20675	COG2814	Major facilitator Superfamily
At12D13_RS20690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
At12D13_RS20700	COG2207	Transcriptional regulator
At12D13_RS20705	COG0668	transmembrane transport
At12D13_RS20715	COG4566	intracellular signal transduction
At12D13_RS20735	COG0668	transmembrane transport
At12D13_RS20740	COG4191	Histidine kinase
At12D13_RS20745	COG5002	protein histidine kinase activity
At12D13_RS20745	COG2205	protein histidine kinase activity
At12D13_RS20745	COG0784	Response regulator, receiver
At12D13_RS20750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
At12D13_RS20765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
At12D13_RS20770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D13_RS20790	COG0047	phosphoribosylformylglycinamidine synthase activity
At12D13_RS20795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS20805	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D13_RS20805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D13_RS20815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
At12D13_RS20830	COG1309	transcriptional regulator
At12D13_RS20835	COG1063	alcohol dehydrogenase
At12D13_RS20845	COG1879	ABC-type sugar transport system periplasmic component
At12D13_RS20855	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS21000	COG5001	Diguanylate cyclase
At12D13_RS21020	COG1253	flavin adenine dinucleotide binding
At12D13_RS21035	COG3842	ATPase activity
At12D13_RS21040	COG0395	ABC-type sugar transport system, permease component
At12D13_RS21045	COG1175	transmembrane transport
At12D13_RS21060	COG0673	inositol 2-dehydrogenase activity
At12D13_RS21065	COG1609	Transcriptional regulator
At12D13_RS21080	COG1879	ABC-type sugar transport system periplasmic component
At12D13_RS21085	COG1129	ABC transporter
At12D13_RS21090	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS21095	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS21100	COG1609	Transcriptional regulator
At12D13_RS21110	COG0673	inositol 2-dehydrogenase activity
At12D13_RS21170	COG0714	Associated with various cellular activities
At12D13_RS21175	COG3256	nitric oxide reductase
At12D13_RS21205	COG0163	prenyltransferase activity
At12D13_RS21210	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
At12D13_RS21215	COG3189	MarR family transcriptional regulator
At12D13_RS21225	COG0826	peptidase U32
At12D13_RS21265	COG4459	periplasmic nitrate reductase
At12D13_RS21280	COG0243	molybdopterin cofactor binding
At12D13_RS21290	COG3005	denitrification pathway
At12D13_RS21305	COG1960	acyl-CoA dehydrogenase activity
At12D13_RS21310	COG0583	DNA-binding transcription factor activity
At12D13_RS21315	COG1609	Transcriptional regulator
At12D13_RS21325	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D13_RS21335	COG3842	ATPase activity
At12D13_RS21345	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
At12D13_RS21355	COG1473	amidohydrolase
At12D13_RS21370	COG0747	negative chemotaxis
At12D13_RS21375	COG0601	transmembrane transport
At12D13_RS21380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS21385	COG0444	Belongs to the ABC transporter superfamily
At12D13_RS21390	COG4608	Belongs to the ABC transporter superfamily
At12D13_RS21395	COG0583	DNA-binding transcription factor activity
At12D13_RS21400	COG0747	negative chemotaxis
At12D13_RS21410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS21415	COG0154	amidase activity
At12D13_RS21420	COG0693	protein deglycase activity
At12D13_RS21430	COG1473	amidohydrolase
At12D13_RS21435	COG4172	Belongs to the ABC transporter superfamily
At12D13_RS21440	COG2390	Transcriptional regulator
At12D13_RS21450	COG1175	transmembrane transport
At12D13_RS21455	COG0395	ABC-type sugar transport system, permease component
At12D13_RS21470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
At12D13_RS21480	COG1737	Transcriptional regulator
At12D13_RS21505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
At12D13_RS21525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
At12D13_RS21530	COG1414	Transcriptional regulator
At12D13_RS21535	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS21545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
At12D13_RS21550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
At12D13_RS21555	COG1121	(ABC) transporter
At12D13_RS21560	COG0803	Belongs to the bacterial solute-binding protein 9 family
At12D13_RS21575	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
At12D13_RS21585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
At12D13_RS21590	COG3273	potassium ion transport
At12D13_RS21590	COG0471	metal ion transport
At12D13_RS21595	COG1253	flavin adenine dinucleotide binding
At12D13_RS21620	COG1609	Transcriptional regulator
At12D13_RS21625	COG1070	Carbohydrate kinase
At12D13_RS21635	COG2115	Belongs to the xylose isomerase family
At12D13_RS21650	COG0778	Nitroreductase
At12D13_RS21655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
At12D13_RS21660	COG2011	ABC-type metal ion transport system permease component
At12D13_RS21670	COG3300	MHYT domain
At12D13_RS21670	COG5001	Diguanylate cyclase
At12D13_RS21675	COG1054	Belongs to the UPF0176 family
At12D13_RS21685	COG2954	triphosphatase activity
At12D13_RS21690	COG0800	Aldolase
At12D13_RS21715	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
At12D13_RS21750	COG0523	cobalamin synthesis protein
At12D13_RS21760	COG1846	Transcriptional regulator
At12D13_RS21765	COG1609	Transcriptional regulator
At12D13_RS21770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_RS21775	COG0673	inositol 2-dehydrogenase activity
At12D13_RS21785	COG3718	enzyme involved in inositol metabolism
At12D13_RS21795	COG3962	Belongs to the TPP enzyme family
At12D13_RS21800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_RS21815	COG0411	ABC transporter
At12D13_RS21830	COG0683	leucine binding
At12D13_RS21850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS21860	COG0747	negative chemotaxis
At12D13_RS21885	COG3185	4-Hydroxyphenylpyruvate dioxygenase
At12D13_RS21885	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_RS21895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
At12D13_RS21900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
At12D13_RS21905	COG1126	abc transporter atp-binding protein
At12D13_RS21910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS21915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS21920	COG0765	amino acid transport
At12D13_RS21925	COG0765	amino acid transport
At12D13_RS21935	COG3485	protocatechuate 3,4-dioxygenase
At12D13_RS21940	COG3485	protocatechuate 3,4-dioxygenase
At12D13_RS21945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
At12D13_RS21955	COG0583	DNA-binding transcription factor activity
At12D13_RS21970	COG1414	Transcriptional regulator
At12D13_RS21980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
At12D13_RS21985	COG0183	Belongs to the thiolase family
At12D13_RS21990	COG1609	Transcriptional regulator
At12D13_RS22005	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_RS22010	COG0673	inositol 2-dehydrogenase activity
At12D13_RS22020	COG1609	Transcriptional regulator
At12D13_RS22025	COG0395	ABC-type sugar transport system, permease component
At12D13_RS22030	COG1175	transmembrane transport
At12D13_RS22035	COG3842	ATPase activity
At12D13_RS22045	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
At12D13_RS22065	COG1940	carbohydrate kinase activity
At12D13_RS22075	COG3842	ATPase activity
At12D13_RS22080	COG4149	molybdate abc transporter
At12D13_RS22090	COG0584	glycerophosphoryl diester phosphodiesterase
At12D13_RS22095	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_RS22100	COG0300	oxidoreductase activity
At12D13_RS22120	COG3842	ATPase activity
At12D13_RS22175	COG3177	Filamentation induced by cAMP protein fic
At12D13_RS22205	COG0385	Bile acid
At12D13_RS22210	COG0667	Aldo Keto reductase
At12D13_RS22215	COG0583	DNA-binding transcription factor activity
At12D13_RS22225	COG0179	Fumarylacetoacetate (FAA) hydrolase
At12D13_RS22235	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS22245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_RS22255	COG1414	Transcriptional regulator
At12D13_RS22260	COG1132	(ABC) transporter
At12D13_RS22295	COG1216	Glycosyl transferase, family 2
At12D13_RS22295	COG0438	transferase activity, transferring glycosyl groups
At12D13_RS22320	COG3754	Rhamnan synthesis protein F
At12D13_RS22330	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
At12D13_RS22335	COG1091	dTDP-4-dehydrorhamnose reductase activity
At12D13_RS22340	COG1088	dTDP-glucose 4,6-dehydratase activity
At12D13_RS22345	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
At12D13_RS22360	COG0444	Belongs to the ABC transporter superfamily
At12D13_RS22365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS22370	COG0601	transmembrane transport
At12D13_RS22375	COG2186	Transcriptional regulator
At12D13_RS22380	COG1312	Catalyzes the dehydration of D-mannonate
At12D13_RS22385	COG0747	negative chemotaxis
At12D13_RS22395	COG5001	Diguanylate cyclase
At12D13_RS22395	COG3300	MHYT domain
At12D13_RS22400	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS22410	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
At12D13_RS22420	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
At12D13_RS22425	COG0306	phosphate transporter
At12D13_RS22430	COG1392	Phosphate transport regulator
At12D13_RS22455	COG5002	protein histidine kinase activity
At12D13_RS22470	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
At12D13_RS22485	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_RS22500	COG3119	arylsulfatase activity
At12D13_RS22505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_RS22510	COG3842	ATPase activity
At12D13_RS22515	COG0165	Argininosuccinate lyase
At12D13_RS22520	COG0395	ABC-type sugar transport system, permease component
At12D13_RS22525	COG1175	transmembrane transport
At12D13_RS22530	COG2182	Extracellular solute-binding protein
At12D13_RS22535	COG1940	carbohydrate kinase activity
At12D13_RS22560	COG1486	melibiose metabolic process
At12D13_RS22565	COG0747	negative chemotaxis
At12D13_RS22570	COG0601	transmembrane transport
At12D13_RS22575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS22580	COG4172	Belongs to the ABC transporter superfamily
At12D13_RS22585	COG1486	melibiose metabolic process
At12D13_RS22590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_RS22595	COG0842	Transport permease protein
At12D13_RS22595	COG1129	ABC transporter
At12D13_RS22600	COG0842	Transport permease protein
At12D13_RS22615	COG0784	Response regulator, receiver
At12D13_RS22620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
At12D13_RS22630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_RS22635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
At12D13_RS22655	COG0765	amino acid transport
At12D13_RS22665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_RS22675	COG3938	Belongs to the proline racemase family
At12D13_RS22680	COG1609	Transcriptional regulator
At12D13_RS22690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS22695	COG0765	amino acid transport
At12D13_RS22700	COG0765	amino acid transport
At12D13_RS22710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_RS22725	COG0402	S-adenosylhomocysteine deaminase activity
At12D13_RS22735	COG0601	transmembrane transport
At12D13_RS22740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS22750	COG0402	S-adenosylhomocysteine deaminase activity
At12D13_RS22755	COG0444	Belongs to the ABC transporter superfamily
At12D13_RS22760	COG4608	Belongs to the ABC transporter superfamily
At12D13_RS22765	COG1802	Transcriptional regulator
At12D13_RS22770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
At12D13_RS22795	COG3383	formate dehydrogenase (NAD+) activity
At12D13_RS22805	COG2223	nitrite transmembrane transporter activity
At12D13_RS22835	COG3237	CsbD-like
At12D13_RS22845	COG2186	Transcriptional regulator
At12D13_RS22850	COG0747	negative chemotaxis
At12D13_RS22855	COG0601	transmembrane transport
At12D13_RS22860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS22865	COG0405	Gamma-glutamyltransferase
At12D13_RS22885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
At12D13_RS22890	COG3181	Tripartite tricarboxylate transporter family receptor
At12D13_RS22895	COG5265	(ABC) transporter
At12D13_RS22900	COG0488	(ABC) transporter
At12D13_RS22925	COG1049	propionate catabolic process, 2-methylcitrate cycle
At12D13_RS22930	COG0840	transmembrane signaling receptor activity
At12D13_RS22940	COG0110	maltose O-acetyltransferase activity
At12D13_RS22950	COG1063	alcohol dehydrogenase
At12D13_RS22955	COG3284	Transcriptional regulator
At12D13_RS22975	COG1129	ABC transporter
At12D13_RS22980	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS22985	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS23000	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_RS23010	COG1126	abc transporter atp-binding protein
At12D13_RS23015	COG0765	amino acid transport
At12D13_RS23020	COG0765	amino acid transport
At12D13_RS23025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS23030	COG3608	succinylglutamate desuccinylase aspartoacylase
At12D13_RS23035	COG0006	proline dipeptidase activity
At12D13_RS23040	COG2423	ornithine cyclodeaminase activity
At12D13_RS23045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
At12D13_RS23050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D13_RS23055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
At12D13_RS23060	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_RS23065	COG1522	sequence-specific DNA binding
At12D13_RS23070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
At12D13_RS23100	COG2140	Oxalate decarboxylase
At12D13_RS23115	COG4566	intracellular signal transduction
At12D13_RS23125	COG0243	molybdopterin cofactor binding
At12D13_RS23130	COG0783	Belongs to the Dps family
At12D13_RS23145	COG0596	Alpha beta hydrolase
At12D13_RS23155	COG1764	response to oxidative stress
At12D13_RS23170	COG0596	Alpha beta hydrolase
At12D13_RS23205	COG0784	Response regulator, receiver
At12D13_RS23205	COG4191	Histidine kinase
At12D13_RS23215	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D13_RS23220	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D13_RS23230	COG3842	ATPase activity
At12D13_RS23235	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_RS23250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_RS23275	COG2197	response regulator
At12D13_RS23280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
At12D13_RS23285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
At12D13_RS23295	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
At12D13_RS23300	COG4310	Domain of unknown function (DUF2172)
At12D13_RS23305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_RS23315	COG2197	response regulator
At12D13_RS23320	COG4566	intracellular signal transduction
At12D13_RS23350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
At12D13_RS23370	COG0438	transferase activity, transferring glycosyl groups
At12D13_RS23385	COG1522	sequence-specific DNA binding
At12D13_RS23405	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS23415	COG0183	Belongs to the thiolase family
At12D13_RS23420	COG1414	Transcriptional regulator
At12D13_RS23430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_RS23470	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
At12D13_RS23530	COG1475	DNA binding
At12D13_RS23535	COG0640	Transcriptional regulator
At12D13_RS23550	COG1126	abc transporter atp-binding protein
At12D13_RS23555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS23560	COG1609	Transcriptional regulator
At12D13_RS23585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
At12D13_RS23620	COG1196	nuclear chromosome segregation
At12D13_RS23625	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
At12D13_RS23635	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
At12D13_RS23685	COG0667	Aldo Keto reductase
At12D13_RS23695	COG2814	Major facilitator Superfamily
At12D13_RS23715	COG2080	2 iron, 2 sulfur cluster binding
At12D13_RS23720	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
At12D13_RS23725	COG1529	Aldehyde oxidase and xanthine dehydrogenase
At12D13_RS23730	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
At12D13_RS23795	COG1280	lysine exporter protein (LysE YggA)
At12D13_RS23810	COG2197	response regulator
At12D13_RS23815	COG4585	Histidine kinase
At12D13_RS23830	COG1733	regulation of RNA biosynthetic process
At12D13_RS23865	COG1309	transcriptional regulator
At12D13_RS23875	COG0583	DNA-binding transcription factor activity
At12D13_RS23880	COG1073	alpha beta
At12D13_RS23885	COG1073	alpha beta
At12D13_RS23895	COG0596	Alpha beta hydrolase
At12D13_RS23925	COG1132	(ABC) transporter
At12D13_RS23955	COG0784	Response regulator, receiver
At12D13_RS23990	COG4095	Psort location CytoplasmicMembrane, score
At12D13_RS24030	COG0753	catalase activity
At12D13_RS24035	COG3685	Protein conserved in bacteria
At12D13_RS24065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
At12D13_RS24070	COG0297	glycogen (starch) synthase activity
At12D13_RS24160	COG1609	Transcriptional regulator
At12D13_RS24185	COG0673	inositol 2-dehydrogenase activity
At12D13_RS24195	COG4608	Belongs to the ABC transporter superfamily
At12D13_RS24205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS24210	COG0601	transmembrane transport
At12D13_RS24215	COG0747	negative chemotaxis
At12D13_RS24220	COG1802	Transcriptional regulator
At12D13_RS24230	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_RS24335	COG1175	transmembrane transport
At12D13_RS24340	COG0395	ABC-type sugar transport system, permease component
At12D13_RS24350	COG3842	ATPase activity
At12D13_RS24355	COG1737	Transcriptional regulator
At12D13_RS24360	COG1846	Transcriptional regulator
At12D13_RS24375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_RS24385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_RS24390	COG0601	transmembrane transport
At12D13_RS24395	COG0747	negative chemotaxis
At12D13_RS24410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
At12D13_RS24415	COG1454	alcohol dehydrogenase
At12D13_RS24425	COG3395	kinase activity
At12D13_RS24440	COG1609	Transcriptional regulator
At12D13_RS24490	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
At12D13_RS24495	COG3920	Histidine kinase
At12D13_RS24500	COG0583	DNA-binding transcription factor activity
At12D13_RS24505	COG2267	carboxylic ester hydrolase activity
At12D13_RS24530	COG1505	serine-type exopeptidase activity
At12D13_RS24540	COG1505	serine-type exopeptidase activity
At12D13_RS24550	COG0642	Histidine kinase
At12D13_RS24555	COG0745	RESPONSE REGULATOR receiver
At12D13_RS24560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
At12D13_RS24565	COG0583	DNA-binding transcription factor activity
At12D13_RS24580	COG0372	Belongs to the citrate synthase family
At12D13_RS24600	COG4774	siderophore transport
At12D13_RS24605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
At12D13_RS24615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_RS24620	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_RS24625	COG1120	ATPase activity
At12D13_RS24645	COG0640	Transcriptional regulator
At12D13_RS24650	COG0431	NADPH-dependent FMN reductase
At12D13_RS24660	COG0604	alcohol dehydrogenase
At12D13_RS24675	COG0583	DNA-binding transcription factor activity
At12D13_RS24680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D13_RS24685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
At12D13_RS24705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_RS24745	COG0784	Response regulator, receiver
At12D13_RS24745	COG4191	Histidine kinase
At12D13_RS24755	COG3177	Filamentation induced by cAMP protein fic
At12D13_RS24790	COG2268	Band 7 protein
At12D13_RS24810	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS24815	COG0583	DNA-binding transcription factor activity
At12D13_RS24845	COG0583	DNA-binding transcription factor activity
At12D13_RS24860	COG1177	transmembrane transport
At12D13_RS24865	COG3842	ATPase activity
At12D13_RS24870	COG2072	flavoprotein involved in K transport
At12D13_RS24890	COG0534	Mate efflux family protein
At12D13_RS24915	COG1609	Transcriptional regulator
At12D13_RS24920	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_RS24925	COG0673	inositol 2-dehydrogenase activity
At12D13_RS24935	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_RS24945	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS24970	COG2972	Histidine kinase
At12D13_RS24970	COG0840	transmembrane signaling receptor activity
At12D13_RS24980	COG4221	oxidoreductase activity
At12D13_RS24985	COG1902	pentaerythritol trinitrate reductase activity
At12D13_RS24990	COG0596	Alpha beta hydrolase
At12D13_RS25000	COG3831	ATPase activity
At12D13_RS25005	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D13_RS25025	COG0577	efflux transmembrane transporter activity
At12D13_RS25040	COG3734	2-keto-3-deoxy-galactonokinase
At12D13_RS25045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_RS25050	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_RS25060	COG1175	transmembrane transport
At12D13_RS25065	COG0395	ABC-type sugar transport system, permease component
At12D13_RS25070	COG3842	ATPase activity
At12D13_RS25075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
At12D13_RS25080	COG1414	Transcriptional regulator
At12D13_RS25085	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS25090	COG3158	transport of potassium into the cell
At12D13_RS25105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
At12D13_RS25130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D13_RS25140	COG0504	CTP synthase activity
At12D13_RS25145	COG0006	proline dipeptidase activity
At12D13_RS25150	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_RS25155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
At12D13_RS25165	COG0765	amino acid transport
At12D13_RS25170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_RS25220	COG0753	catalase activity
At12D13_RS25235	COG3685	Protein conserved in bacteria
At12D13_RS25245	COG1309	transcriptional regulator
At12D13_RS25250	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
At12D13_RS25255	COG2080	2 iron, 2 sulfur cluster binding
At12D13_RS25260	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
At12D13_RS25265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
At12D13_RS25270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
At12D13_RS25310	COG4191	Histidine kinase
At12D13_RS25310	COG0784	Response regulator, receiver
At12D13_RS25315	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
At12D13_RS25330	COG1278	Cold shock
At12D13_RS25380	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_RS25400	COG0431	NADPH-dependent FMN reductase
At12D13_RS25405	COG3920	Histidine kinase
At12D13_RS25460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
At12D13_RS25470	COG1566	PFAM secretion protein HlyD family protein
At12D13_RS25490	COG2207	Transcriptional regulator
At12D13_RS25530	COG1192	Involved in chromosome partitioning
At12D13_RS25535	COG1475	DNA binding
At12D13_RS25540	COG1414	Transcriptional regulator
At12D13_RS25555	COG4191	Histidine kinase
At12D13_RS25555	COG0784	Response regulator, receiver
At12D13_RS25565	COG0395	ABC-type sugar transport system, permease component
At12D13_RS25605	COG4572	Cation transport regulator
At12D13_RS25615	COG0028	Belongs to the TPP enzyme family
At12D13_RS25670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D13_RS25675	COG2010	Cytochrome c
At12D13_RS25675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
At12D13_RS25685	COG0243	molybdopterin cofactor binding
At12D13_RS25695	COG2010	Cytochrome c
At12D13_RS25695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
At12D13_RS25700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D13_RS25760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
At12D13_RS25770	COG0297	glycogen (starch) synthase activity
At12D13_RS25775	COG2124	cytochrome p450
At12D13_RS25805	COG3685	Protein conserved in bacteria
At12D13_RS25825	COG1573	uracil-dna glycosylase
At12D13_RS25835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_RS25860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_RS25920	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_RS25960	COG3177	Filamentation induced by cAMP protein fic
At12D13_RS25995	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
At12D13_RS26000	COG4585	Histidine kinase
At12D13_RS26005	COG0784	Response regulator, receiver
At12D13_RS26030	COG0583	DNA-binding transcription factor activity
At12D13_RS26040	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D13_RS26045	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D13_RS26055	COG1758	RNA polymerase activity
At12D13_RS26145	COG1487	ribonuclease activity
At12D13_RS26155	COG3706	GGDEF domain
At12D13_RS26420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
At12D13_RS26540	COG0596	Alpha beta hydrolase