locus-tag	class	description
F3P66_RS00010	COG3030	protein affecting phage T7 exclusion by the F plasmid
F3P66_RS00015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F3P66_RS00025	COG0237	dephospho-CoA kinase activity
F3P66_RS00030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F3P66_RS00035	COG0424	maF-like protein
F3P66_RS00040	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F3P66_RS00045	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F3P66_RS00050	COG1981	membrane
F3P66_RS00055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F3P66_RS00060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F3P66_RS00065	COG0445	tRNA wobble uridine modification
F3P66_RS00070	COG0357	Ribosomal RNA small subunit methyltransferase G
F3P66_RS00090	COG0501	Belongs to the peptidase M48B family
F3P66_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F3P66_RS00095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F3P66_RS00105	COG0138	bifunctional purine biosynthesis protein purh
F3P66_RS00110	COG2721	sulfolactate sulfo-lyase activity
F3P66_RS00115	COG2186	Transcriptional regulator
F3P66_RS00120	COG1129	ABC transporter
F3P66_RS00125	COG4214	carbohydrate transport
F3P66_RS00145	COG1063	alcohol dehydrogenase
F3P66_RS00150	COG0246	Mannitol dehydrogenase
F3P66_RS00155	COG3254	rhamnose metabolic process
F3P66_RS00160	COG4948	Mandelate Racemase Muconate Lactonizing
F3P66_RS00175	COG1492	cobalamin metabolic process
F3P66_RS00240	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
F3P66_RS00245	COG1648	precorrin-2 dehydrogenase activity
F3P66_RS00245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F3P66_RS00250	COG1797	cobyrinic acid a,c-diamide synthase activity
F3P66_RS00255	COG1858	cytochrome C peroxidase
F3P66_RS00260	COG0473	3-isopropylmalate dehydrogenase activity
F3P66_RS00265	COG0066	3-isopropylmalate dehydratase activity
F3P66_RS00290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F3P66_RS00295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F3P66_RS00310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F3P66_RS00315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F3P66_RS00320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F3P66_RS00325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F3P66_RS00330	COG0799	negative regulation of ribosome biogenesis
F3P66_RS00335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F3P66_RS00345	COG0793	Belongs to the peptidase S41A family
F3P66_RS00355	COG0494	nUDIX hydrolase
F3P66_RS00370	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS00385	COG2270	Major facilitator Superfamily
F3P66_RS00390	COG2902	Dehydrogenase
F3P66_RS00395	COG1329	Transcriptional regulator
F3P66_RS00405	COG0745	RESPONSE REGULATOR receiver
F3P66_RS00420	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F3P66_RS00425	COG1674	ftsk spoiiie
F3P66_RS00430	COG0004	ammonium transporteR
F3P66_RS00435	COG0347	Belongs to the P(II) protein family
F3P66_RS00440	COG1946	Acyl-CoA thioesterase
F3P66_RS00445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F3P66_RS00460	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F3P66_RS00475	COG0495	leucyl-tRNA aminoacylation
F3P66_RS00480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F3P66_RS00490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F3P66_RS00495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F3P66_RS00500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F3P66_RS00505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F3P66_RS00515	COG2186	Transcriptional regulator
F3P66_RS00520	COG0277	FAD linked oxidase domain protein
F3P66_RS00525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F3P66_RS00530	COG2084	Dehydrogenase
F3P66_RS00535	COG0129	dihydroxy-acid dehydratase activity
F3P66_RS00545	COG0579	oxidoreductase
F3P66_RS00550	COG1473	amidohydrolase
F3P66_RS00555	COG3459	Glycosyltransferase 36 associated
F3P66_RS00565	COG1132	(ABC) transporter
F3P66_RS00570	COG2197	response regulator
F3P66_RS00575	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F3P66_RS00580	COG1349	DNA-binding transcription factor activity
F3P66_RS00585	COG2223	nitrite transmembrane transporter activity
F3P66_RS00590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F3P66_RS00595	COG2885	chlorophyll binding
F3P66_RS00600	COG0142	geranyltranstransferase activity
F3P66_RS00605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F3P66_RS00615	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F3P66_RS00625	COG0488	(ABC) transporter
F3P66_RS00645	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
F3P66_RS00670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F3P66_RS00675	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
F3P66_RS00680	COG0335	large ribosomal subunit rRNA binding
F3P66_RS00690	COG0336	Belongs to the RNA methyltransferase TrmD family
F3P66_RS00695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F3P66_RS00700	COG0228	four-way junction DNA binding
F3P66_RS00705	COG0287	Prephenate dehydrogenase
F3P66_RS00705	COG1605	Chorismate mutase
F3P66_RS00710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F3P66_RS00720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F3P66_RS00725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F3P66_RS00730	COG0552	protein localization to endoplasmic reticulum
F3P66_RS00735	COG2917	probably involved in intracellular septation
F3P66_RS00760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F3P66_RS00765	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F3P66_RS00770	COG4133	protoheme IX ABC transporter activity
F3P66_RS00775	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F3P66_RS00790	COG0670	Belongs to the BI1 family
F3P66_RS00800	COG4181	ATPase activity
F3P66_RS00810	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F3P66_RS00815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F3P66_RS00820	COG2154	pterin-4-alpha-carbinolamine dehydratase
F3P66_RS00835	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F3P66_RS00845	COG4120	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS00850	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
F3P66_RS00855	COG1280	lysine exporter protein (LysE YggA)
F3P66_RS00865	COG0137	argininosuccinate synthase activity
F3P66_RS00875	COG1846	Transcriptional regulator
F3P66_RS00880	COG0339	signal peptide processing
F3P66_RS00885	COG1217	gtp-binding protein TYPA
F3P66_RS00895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F3P66_RS00900	COG1872	DUF167
F3P66_RS00940	COG0181	hydroxymethylbilane synthase activity
F3P66_RS00945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F3P66_RS00950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F3P66_RS00965	COG2264	protein methyltransferase activity
F3P66_RS01000	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F3P66_RS01005	COG0039	L-malate dehydrogenase activity
F3P66_RS01010	COG0045	succinate-CoA ligase (ADP-forming) activity
F3P66_RS01015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F3P66_RS01035	COG1280	lysine exporter protein (LysE YggA)
F3P66_RS01060	COG4974	Belongs to the 'phage' integrase family
F3P66_RS01075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F3P66_RS01080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F3P66_RS01085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F3P66_RS01090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F3P66_RS01095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F3P66_RS01100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F3P66_RS01110	COG0835	chemotaxis
F3P66_RS01120	COG0729	surface antigen
F3P66_RS01130	COG0156	8-amino-7-oxononanoate synthase activity
F3P66_RS01135	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F3P66_RS01140	COG0671	phosphoesterase, PA-phosphatase related
F3P66_RS01150	COG1940	carbohydrate kinase activity
F3P66_RS01155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F3P66_RS01160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3P66_RS01165	COG2188	Transcriptional regulator
F3P66_RS01175	COG1175	transmembrane transport
F3P66_RS01180	COG0395	ABC-type sugar transport system, permease component
F3P66_RS01190	COG3842	ATPase activity
F3P66_RS01200	COG1737	Transcriptional regulator
F3P66_RS01205	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS01225	COG3142	Participates in the control of copper homeostasis
F3P66_RS01230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F3P66_RS01235	COG0438	transferase activity, transferring glycosyl groups
F3P66_RS01245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS01250	COG0601	transmembrane transport
F3P66_RS01255	COG4166	transmembrane transport
F3P66_RS01275	COG0438	transferase activity, transferring glycosyl groups
F3P66_RS01300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F3P66_RS01325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F3P66_RS01335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3P66_RS01340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F3P66_RS01355	COG2022	thiamine diphosphate biosynthetic process
F3P66_RS01360	COG3191	aminopeptidase activity
F3P66_RS01370	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F3P66_RS01375	COG4149	molybdate abc transporter
F3P66_RS01380	COG0725	ABC transporter, periplasmic molybdate-binding protein
F3P66_RS01385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS01390	COG0583	DNA-binding transcription factor activity
F3P66_RS01405	COG1509	lysine 2,3-aminomutase activity
F3P66_RS01415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F3P66_RS01425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F3P66_RS01430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F3P66_RS01440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F3P66_RS01475	COG1902	pentaerythritol trinitrate reductase activity
F3P66_RS01475	COG0446	pyridine nucleotide-disulphide oxidoreductase
F3P66_RS01485	COG0745	RESPONSE REGULATOR receiver
F3P66_RS01515	COG1960	acyl-CoA dehydrogenase activity
F3P66_RS01560	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F3P66_RS01560	COG0392	lysyltransferase activity
F3P66_RS01580	COG0601	transmembrane transport
F3P66_RS01585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS01590	COG0444	Belongs to the ABC transporter superfamily
F3P66_RS01595	COG4608	Belongs to the ABC transporter superfamily
F3P66_RS01610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F3P66_RS01620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3P66_RS01625	COG3842	ATPase activity
F3P66_RS01630	COG0395	ABC-type sugar transport system, permease component
F3P66_RS01635	COG1175	transmembrane transport
F3P66_RS01650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3P66_RS01665	COG1335	isochorismatase
F3P66_RS01670	COG0251	oxidation-reduction process
F3P66_RS01675	COG2267	carboxylic ester hydrolase activity
F3P66_RS01680	COG0778	Nitroreductase
F3P66_RS01685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F3P66_RS01690	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F3P66_RS01705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F3P66_RS01715	COG0288	reversible hydration of carbon dioxide
F3P66_RS01720	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
F3P66_RS01725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F3P66_RS01745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F3P66_RS01750	COG0657	acetylesterase activity
F3P66_RS01755	COG0583	DNA-binding transcription factor activity
F3P66_RS01770	COG0783	Belongs to the Dps family
F3P66_RS01775	COG4604	ABC transporter, ATP-binding protein
F3P66_RS01780	COG4605	iron ion homeostasis
F3P66_RS01785	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3P66_RS01825	COG2205	protein histidine kinase activity
F3P66_RS01840	COG3721	Heme iron utilization protein
F3P66_RS01850	COG4558	Periplasmic binding protein
F3P66_RS01855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3P66_RS01860	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F3P66_RS01865	COG2832	Protein of unknown function (DUF454)
F3P66_RS01875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F3P66_RS01885	COG0346	lactoylglutathione lyase activity
F3P66_RS01910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F3P66_RS01920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F3P66_RS01930	COG0564	pseudouridine synthase activity
F3P66_RS02005	COG1218	3'(2'),5'-bisphosphate nucleotidase
F3P66_RS02055	COG0784	Response regulator, receiver
F3P66_RS02055	COG5002	protein histidine kinase activity
F3P66_RS02055	COG2198	Histidine kinase
F3P66_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS02065	COG0174	glutamine synthetase
F3P66_RS02080	COG0559	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS02105	COG0829	nickel cation binding
F3P66_RS02110	COG0831	urea catabolic process
F3P66_RS02115	COG3813	Protein conserved in bacteria
F3P66_RS02120	COG0832	Belongs to the urease beta subunit family
F3P66_RS02130	COG3755	Protein conserved in bacteria
F3P66_RS02135	COG1442	glycosyl transferase family 8
F3P66_RS02140	COG0804	urea catabolic process
F3P66_RS02155	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
F3P66_RS02160	COG0830	nickel cation binding
F3P66_RS02165	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F3P66_RS02195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3P66_RS02200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3P66_RS02210	COG0494	nUDIX hydrolase
F3P66_RS02225	COG1309	transcriptional regulator
F3P66_RS02245	COG2346	COG2346, Truncated hemoglobins
F3P66_RS02250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F3P66_RS02280	COG1215	transferase activity, transferring glycosyl groups
F3P66_RS02305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS02310	COG4215	(ABC) transporter
F3P66_RS02320	COG1410	methionine synthase
F3P66_RS02320	COG0646	methionine synthase
F3P66_RS02325	COG2814	Major facilitator Superfamily
F3P66_RS02330	COG0840	transmembrane signaling receptor activity
F3P66_RS02340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F3P66_RS02375	COG4213	ABC transporter substrate-binding protein
F3P66_RS02380	COG1129	ABC transporter
F3P66_RS02385	COG4214	carbohydrate transport
F3P66_RS02400	COG0456	acetyltransferase
F3P66_RS02415	COG1305	Transglutaminase-like
F3P66_RS02435	COG1376	ErfK ybiS ycfS ynhG family protein
F3P66_RS02440	COG2259	Doxx family
F3P66_RS02445	COG0697	spore germination
F3P66_RS02450	COG0513	Belongs to the DEAD box helicase family
F3P66_RS02460	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F3P66_RS02460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS02470	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
F3P66_RS02495	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
F3P66_RS02500	COG2351	hydroxyisourate hydrolase activity
F3P66_RS02510	COG1686	Belongs to the peptidase S11 family
F3P66_RS02515	COG1309	transcriptional regulator
F3P66_RS02525	COG1304	FMN binding
F3P66_RS02540	COG0402	S-adenosylhomocysteine deaminase activity
F3P66_RS02555	COG0583	DNA-binding transcription factor activity
F3P66_RS02575	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS02585	COG0024	Methionine aminopeptidase
F3P66_RS02595	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
F3P66_RS02615	COG1160	GTP binding
F3P66_RS02635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3P66_RS02640	COG0366	Alpha amylase catalytic
F3P66_RS02655	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F3P66_RS02670	COG0512	Glutamine amidotransferase of anthranilate synthase
F3P66_RS02670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F3P66_RS02685	COG2862	Uncharacterized protein family, UPF0114
F3P66_RS02705	COG1435	thymidine kinase activity
F3P66_RS02720	COG4175	Glycine betaine
F3P66_RS02745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F3P66_RS02750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F3P66_RS02765	COG0740	serine-type endopeptidase activity
F3P66_RS02775	COG1595	DNA-templated transcription, initiation
F3P66_RS02790	COG3135	benzoate transporter
F3P66_RS02795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F3P66_RS02805	COG0494	nUDIX hydrolase
F3P66_RS02810	COG0435	Glutathione S-transferase
F3P66_RS02820	COG0477	Major facilitator Superfamily
F3P66_RS02825	COG0454	-acetyltransferase
F3P66_RS02845	COG0714	Associated with various cellular activities
F3P66_RS02855	COG0494	nUDIX hydrolase
F3P66_RS02860	COG0617	tRNA 3'-terminal CCA addition
F3P66_RS02870	COG0408	coproporphyrinogen oxidase activity
F3P66_RS02885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F3P66_RS02890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F3P66_RS02895	COG1132	(ABC) transporter
F3P66_RS02920	COG2857	Cytochrome c1
F3P66_RS02920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F3P66_RS02925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F3P66_RS02945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F3P66_RS02955	COG0193	aminoacyl-tRNA hydrolase activity
F3P66_RS02965	COG5001	Diguanylate cyclase
F3P66_RS02970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F3P66_RS02975	COG5001	Diguanylate cyclase
F3P66_RS02975	COG3300	MHYT domain
F3P66_RS02980	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
F3P66_RS02985	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS02990	COG0840	transmembrane signaling receptor activity
F3P66_RS03005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F3P66_RS03015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F3P66_RS03030	COG1496	oxidoreductase activity
F3P66_RS03040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F3P66_RS03060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3P66_RS03065	COG2205	protein histidine kinase activity
F3P66_RS03070	COG0745	RESPONSE REGULATOR receiver
F3P66_RS03075	COG1846	Transcriptional regulator
F3P66_RS03085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F3P66_RS03090	COG1278	Cold shock
F3P66_RS03105	COG2200	EAL domain
F3P66_RS03105	COG2199	diguanylate cyclase activity
F3P66_RS03110	COG0436	Aminotransferase
F3P66_RS03115	COG0387	Pfam Sodium calcium exchanger
F3P66_RS03140	COG1902	pentaerythritol trinitrate reductase activity
F3P66_RS03150	COG0583	DNA-binding transcription factor activity
F3P66_RS03155	COG0492	ferredoxin-NADP+ reductase activity
F3P66_RS03160	COG1522	sequence-specific DNA binding
F3P66_RS03170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F3P66_RS03185	COG3706	GGDEF domain
F3P66_RS03190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F3P66_RS03205	COG2321	neutral zinc metallopeptidase
F3P66_RS03220	COG0534	Mate efflux family protein
F3P66_RS03235	COG0505	Belongs to the CarA family
F3P66_RS03245	COG0358	DNA primase activity
F3P66_RS03250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F3P66_RS03265	COG0432	Pfam Uncharacterised protein family UPF0047
F3P66_RS03275	COG2968	Membrane
F3P66_RS03335	COG3842	ATPase activity
F3P66_RS03365	COG0531	amino acid
F3P66_RS03370	COG0174	glutamine synthetase
F3P66_RS03385	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS03410	COG2814	Major facilitator Superfamily
F3P66_RS03430	COG0251	oxidation-reduction process
F3P66_RS03445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F3P66_RS03450	COG2267	carboxylic ester hydrolase activity
F3P66_RS03460	COG2226	methyltransferase
F3P66_RS03480	COG4106	trans-aconitate 2-methyltransferase activity
F3P66_RS03510	COG3023	N-Acetylmuramoyl-L-alanine amidase
F3P66_RS03555	COG3766	membrane
F3P66_RS03560	COG2001	Belongs to the MraZ family
F3P66_RS03565	COG0275	rRNA processing
F3P66_RS03580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F3P66_RS03590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F3P66_RS03595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F3P66_RS03605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F3P66_RS03610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F3P66_RS03615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F3P66_RS03620	COG3300	MHYT domain
F3P66_RS03620	COG5001	Diguanylate cyclase
F3P66_RS03625	COG0477	Major facilitator Superfamily
F3P66_RS03635	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F3P66_RS03640	COG0849	cell division
F3P66_RS03645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F3P66_RS03655	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3P66_RS03660	COG0497	DNA recombination
F3P66_RS03665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F3P66_RS03675	COG1247	-acetyltransferase
F3P66_RS03685	COG0583	DNA-binding transcription factor activity
F3P66_RS03690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F3P66_RS03700	COG0835	chemotaxis
F3P66_RS03710	COG1999	signal sequence binding
F3P66_RS03715	COG2264	protein methyltransferase activity
F3P66_RS03725	COG0006	proline dipeptidase activity
F3P66_RS03745	COG1335	isochorismatase
F3P66_RS03800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F3P66_RS03805	COG0277	FAD linked oxidase domain protein
F3P66_RS03840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F3P66_RS03850	COG0330	HflC and HflK could
F3P66_RS03855	COG0330	HflC and HflK could
F3P66_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS03875	COG0560	Phosphoserine phosphatase
F3P66_RS03875	COG3830	Belongs to the UPF0237 family
F3P66_RS03880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F3P66_RS03890	COG0028	Belongs to the TPP enzyme family
F3P66_RS03895	COG0440	acetolactate synthase activity
F3P66_RS03910	COG0656	L-ascorbic acid biosynthetic process
F3P66_RS03940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F3P66_RS03945	COG2197	response regulator
F3P66_RS03950	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F3P66_RS03955	COG1252	NADH dehydrogenase
F3P66_RS03960	COG1064	alcohol dehydrogenase
F3P66_RS03965	COG2207	Transcriptional regulator
F3P66_RS03975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F3P66_RS03985	COG4115	mRNA cleavage
F3P66_RS04000	COG1840	ABC-type Fe3 transport system, periplasmic component
F3P66_RS04010	COG3842	ATPase activity
F3P66_RS04020	COG3706	GGDEF domain
F3P66_RS04035	COG0484	heat shock protein binding
F3P66_RS04055	COG2382	esterase
F3P66_RS04065	COG1733	regulation of RNA biosynthetic process
F3P66_RS04070	COG2910	NAD(P)H-binding
F3P66_RS04100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F3P66_RS04115	COG4251	negative regulation of phosphorylation
F3P66_RS04120	COG0784	Response regulator, receiver
F3P66_RS04125	COG2202	Pas domain
F3P66_RS04125	COG3920	Histidine kinase
F3P66_RS04130	COG0784	Response regulator, receiver
F3P66_RS04135	COG2205	protein histidine kinase activity
F3P66_RS04135	COG2198	Histidine kinase
F3P66_RS04135	COG0784	Response regulator, receiver
F3P66_RS04135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS04170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F3P66_RS04190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F3P66_RS04210	COG3895	Periplasmic Protein
F3P66_RS04215	COG0861	Integral membrane protein TerC family
F3P66_RS04220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F3P66_RS04225	COG1086	Polysaccharide biosynthesis protein
F3P66_RS04235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F3P66_RS04245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F3P66_RS04250	COG0081	regulation of translation
F3P66_RS04255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F3P66_RS04260	COG0222	ribosome binding
F3P66_RS04265	COG0085	RNA polymerase activity
F3P66_RS04270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F3P66_RS04290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F3P66_RS04295	COG0049	tRNA binding
F3P66_RS04300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F3P66_RS04305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F3P66_RS04310	COG0051	transcription antitermination factor activity, RNA binding
F3P66_RS04315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F3P66_RS04320	COG0088	Forms part of the polypeptide exit tunnel
F3P66_RS04325	COG0089	rRNA binding
F3P66_RS04330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F3P66_RS04335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F3P66_RS04340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F3P66_RS04345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F3P66_RS04350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F3P66_RS04355	COG0255	Belongs to the universal ribosomal protein uL29 family
F3P66_RS04360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F3P66_RS04365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F3P66_RS04370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F3P66_RS04375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F3P66_RS04380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F3P66_RS04385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F3P66_RS04390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F3P66_RS04395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F3P66_RS04400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F3P66_RS04405	COG1841	ribosomal large subunit assembly
F3P66_RS04410	COG0200	Binds to the 23S rRNA
F3P66_RS04415	COG0201	protein transport
F3P66_RS04420	COG0563	adenylate kinase activity
F3P66_RS04425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F3P66_RS04430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F3P66_RS04435	COG0202	RNA polymerase activity
F3P66_RS04440	COG0203	ribosomal protein L17
F3P66_RS04445	COG3739	integral membrane protein
F3P66_RS04455	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
F3P66_RS04460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F3P66_RS04465	COG0129	dihydroxy-acid dehydratase activity
F3P66_RS04480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3P66_RS04485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F3P66_RS04515	COG0842	Transport permease protein
F3P66_RS04525	COG2390	Transcriptional regulator
F3P66_RS04530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F3P66_RS04535	COG3958	Transketolase
F3P66_RS04540	COG3959	Transketolase, thiamine diphosphate binding domain
F3P66_RS04545	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS04555	COG1129	ABC transporter
F3P66_RS04560	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS04565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3P66_RS04580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F3P66_RS04585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F3P66_RS04595	COG2202	Pas domain
F3P66_RS04595	COG2205	protein histidine kinase activity
F3P66_RS04605	COG1573	uracil-dna glycosylase
F3P66_RS04610	COG1522	sequence-specific DNA binding
F3P66_RS04615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F3P66_RS04625	COG5425	PFAM Usg family protein
F3P66_RS04635	COG4215	(ABC) transporter
F3P66_RS04640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS04650	COG2313	pseudouridylate synthase activity
F3P66_RS04655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3P66_RS04660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F3P66_RS04665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F3P66_RS04680	COG0538	isocitrate dehydrogenase activity
F3P66_RS04690	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
F3P66_RS04695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F3P66_RS04705	COG1280	lysine exporter protein (LysE YggA)
F3P66_RS04720	COG0861	Integral membrane protein TerC family
F3P66_RS04725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F3P66_RS04730	COG2066	Belongs to the glutaminase family
F3P66_RS04735	COG0037	tRNA processing
F3P66_RS04740	COG0483	inositol monophosphate 1-phosphatase activity
F3P66_RS04745	COG0483	inositol monophosphate 1-phosphatase activity
F3P66_RS04750	COG2814	Major facilitator Superfamily
F3P66_RS04755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F3P66_RS04775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F3P66_RS04785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3P66_RS04800	COG0047	phosphoribosylformylglycinamidine synthase activity
F3P66_RS04805	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F3P66_RS04810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F3P66_RS04820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F3P66_RS04850	COG0513	Belongs to the DEAD box helicase family
F3P66_RS04855	COG0739	heme binding
F3P66_RS04860	COG2833	Protein of unknown function (DUF455)
F3P66_RS04865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F3P66_RS04875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F3P66_RS04880	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F3P66_RS04885	COG2945	thiolester hydrolase activity
F3P66_RS04890	COG1104	cysteine desulfurase activity
F3P66_RS04895	COG0719	Fe-S assembly protein
F3P66_RS04900	COG0396	ATPase activity
F3P66_RS04905	COG0719	Fe-S assembly protein
F3P66_RS04910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F3P66_RS04915	COG2151	metal-sulfur cluster biosynthetic enzyme
F3P66_RS04930	COG0577	efflux transmembrane transporter activity
F3P66_RS04930	COG1136	(ABC) transporter
F3P66_RS04935	COG0577	efflux transmembrane transporter activity
F3P66_RS04935	COG1136	(ABC) transporter
F3P66_RS04950	COG2267	carboxylic ester hydrolase activity
F3P66_RS05000	COG1278	Cold shock
F3P66_RS05030	COG0785	Cytochrome C biogenesis protein
F3P66_RS05035	COG0679	Auxin Efflux Carrier
F3P66_RS05040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F3P66_RS05045	COG1183	phosphatidylcholine synthase activity
F3P66_RS05050	COG3845	ABC transporter
F3P66_RS05055	COG4603	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS05060	COG1079	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS05070	COG2186	Transcriptional regulator
F3P66_RS05075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F3P66_RS05080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3P66_RS05095	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F3P66_RS05100	COG3668	Plasmid stabilization system
F3P66_RS05110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F3P66_RS05120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F3P66_RS05130	COG0697	spore germination
F3P66_RS05165	COG0347	Belongs to the P(II) protein family
F3P66_RS05170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F3P66_RS05170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F3P66_RS05180	COG0583	DNA-binding transcription factor activity
F3P66_RS05215	COG1760	l-serine dehydratase
F3P66_RS05245	COG0517	IMP dehydrogenase activity
F3P66_RS05245	COG0516	GMP reductase activity
F3P66_RS05250	COG1752	Esterase of the alpha-beta hydrolase superfamily
F3P66_RS05255	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F3P66_RS05260	COG0302	gtp cyclohydrolase
F3P66_RS05270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F3P66_RS05280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F3P66_RS05295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F3P66_RS05315	COG0628	permease
F3P66_RS05320	COG1132	(ABC) transporter
F3P66_RS05330	COG1914	H( )-stimulated, divalent metal cation uptake system
F3P66_RS05345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F3P66_RS05350	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F3P66_RS05355	COG0589	response to stress
F3P66_RS05360	COG1546	Belongs to the CinA family
F3P66_RS05360	COG1058	Belongs to the CinA family
F3P66_RS05365	COG0655	NAD(P)H dehydrogenase (quinone) activity
F3P66_RS05395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F3P66_RS05405	COG0525	valine-tRNA ligase activity
F3P66_RS05420	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
F3P66_RS05430	COG0316	Belongs to the HesB IscA family
F3P66_RS05435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F3P66_RS05440	COG0018	arginyl-trna synthetase
F3P66_RS05450	COG1472	Belongs to the glycosyl hydrolase 3 family
F3P66_RS05455	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F3P66_RS05460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F3P66_RS05465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F3P66_RS05470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F3P66_RS05475	COG0805	protein transport
F3P66_RS05480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F3P66_RS05485	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F3P66_RS05490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F3P66_RS05495	COG0739	heme binding
F3P66_RS05500	COG1763	Mo-molybdopterin cofactor biosynthetic process
F3P66_RS05505	COG0746	molybdenum cofactor guanylyltransferase activity
F3P66_RS05510	COG2814	Major facilitator Superfamily
F3P66_RS05515	COG0697	spore germination
F3P66_RS05520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F3P66_RS05530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F3P66_RS05530	COG0475	glutathione-regulated potassium exporter activity
F3P66_RS05540	COG3706	GGDEF domain
F3P66_RS05545	COG0303	'Molybdopterin
F3P66_RS05550	COG0315	cyclic pyranopterin monophosphate synthase activity
F3P66_RS05555	COG0134	indole-3-glycerol-phosphate synthase activity
F3P66_RS05560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F3P66_RS05575	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F3P66_RS05590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F3P66_RS05595	COG0343	queuine tRNA-ribosyltransferase activity
F3P66_RS05635	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F3P66_RS05640	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
F3P66_RS05660	COG0544	peptidyl-prolyl cis-trans isomerase activity
F3P66_RS05685	COG1368	sulfuric ester hydrolase activity
F3P66_RS05695	COG0823	Involved in the tonB-independent uptake of proteins
F3P66_RS05700	COG0778	Nitroreductase
F3P66_RS05710	COG0281	malic enzyme
F3P66_RS05710	COG0280	phosphate acetyltransferase
F3P66_RS05725	COG4948	Mandelate Racemase Muconate Lactonizing
F3P66_RS05730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F3P66_RS05735	COG1127	ABC transporter
F3P66_RS05795	COG3264	Mechanosensitive ion channel
F3P66_RS05795	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F3P66_RS05805	COG0745	RESPONSE REGULATOR receiver
F3P66_RS05810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F3P66_RS05815	COG0640	Transcriptional regulator
F3P66_RS05825	COG0740	serine-type endopeptidase activity
F3P66_RS05835	COG2226	methyltransferase
F3P66_RS05840	COG1309	transcriptional regulator
F3P66_RS05850	COG0187	DNA topoisomerase II activity
F3P66_RS05860	COG0149	triose-phosphate isomerase activity
F3P66_RS05870	COG0504	CTP synthase activity
F3P66_RS05880	COG0114	fumarate hydratase activity
F3P66_RS05890	COG0546	phosphoglycolate phosphatase activity
F3P66_RS05895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F3P66_RS05910	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F3P66_RS05925	COG2003	Belongs to the UPF0758 family
F3P66_RS05930	COG0024	Methionine aminopeptidase
F3P66_RS05935	COG1489	DNA binding
F3P66_RS05940	COG3243	poly(R)-hydroxyalkanoic acid synthase
F3P66_RS05955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F3P66_RS05960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3P66_RS05965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F3P66_RS05975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F3P66_RS06020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F3P66_RS06035	COG1126	abc transporter atp-binding protein
F3P66_RS06040	COG0765	amino acid transport
F3P66_RS06045	COG4597	amino acid ABC transporter
F3P66_RS06050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS06055	COG0626	cystathionine gamma-synthase activity
F3P66_RS06070	COG0596	Alpha beta hydrolase
F3P66_RS06085	COG2124	cytochrome p450
F3P66_RS06110	COG1862	Preprotein translocase
F3P66_RS06140	COG1064	alcohol dehydrogenase
F3P66_RS06145	COG0321	lipoyl(octanoyl) transferase activity
F3P66_RS06170	COG0242	peptide deformylase activity
F3P66_RS06180	COG0243	molybdopterin cofactor binding
F3P66_RS06185	COG2239	Acts as a magnesium transporter
F3P66_RS06210	COG0668	transmembrane transport
F3P66_RS06280	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F3P66_RS06290	COG0667	Aldo Keto reductase
F3P66_RS06310	COG1121	(ABC) transporter
F3P66_RS06315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F3P66_RS06330	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3P66_RS06335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F3P66_RS06350	COG0629	single-stranded DNA binding
F3P66_RS06355	COG3609	addiction module antidote protein, CC2985 family
F3P66_RS06365	COG0517	IMP dehydrogenase activity
F3P66_RS06365	COG0617	tRNA 3'-terminal CCA addition
F3P66_RS06365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F3P66_RS06370	COG2095	MarC family integral membrane protein
F3P66_RS06375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F3P66_RS06430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F3P66_RS06440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3P66_RS06445	COG0084	hydrolase, TatD family'
F3P66_RS06450	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F3P66_RS06450	COG0321	lipoyl(octanoyl) transferase activity
F3P66_RS06470	COG0798	PFAM Bile acid sodium symporter
F3P66_RS06480	COG0431	NADPH-dependent FMN reductase
F3P66_RS06485	COG2826	transposase and inactivated derivatives, IS30 family
F3P66_RS06525	COG0450	alkyl hydroperoxide reductase
F3P66_RS06535	COG1671	Belongs to the UPF0178 family
F3P66_RS06545	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F3P66_RS06550	COG0251	oxidation-reduction process
F3P66_RS06570	COG0564	pseudouridine synthase activity
F3P66_RS06575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F3P66_RS06600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F3P66_RS06605	COG0509	glycine decarboxylation via glycine cleavage system
F3P66_RS06610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F3P66_RS06610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F3P66_RS06635	COG0275	rRNA processing
F3P66_RS06650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F3P66_RS06650	COG1648	precorrin-2 dehydrogenase activity
F3P66_RS06660	COG3956	TIGRFAM MazG family protein
F3P66_RS06665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F3P66_RS06670	COG1923	regulation of RNA biosynthetic process
F3P66_RS06675	COG0569	domain protein
F3P66_RS06680	COG2204	response regulator
F3P66_RS06685	COG5000	phosphorelay sensor kinase activity
F3P66_RS06690	COG2204	response regulator
F3P66_RS06695	COG3852	Histidine kinase
F3P66_RS06705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F3P66_RS06705	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F3P66_RS06715	COG2867	negative regulation of translational initiation
F3P66_RS06735	COG0697	spore germination
F3P66_RS06740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F3P66_RS06750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F3P66_RS06760	COG0508	dehydrogenase complex catalyzes the overall conversion of
F3P66_RS06770	COG0508	dehydrogenase complex catalyzes the overall conversion of
F3P66_RS06770	COG0022	dehydrogenase e1 component
F3P66_RS06775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F3P66_RS06785	COG0148	phosphopyruvate hydratase activity
F3P66_RS06790	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F3P66_RS06810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F3P66_RS06825	COG1024	Enoyl-CoA hydratase
F3P66_RS06840	COG1960	acyl-CoA dehydrogenase activity
F3P66_RS06845	COG0683	leucine binding
F3P66_RS06865	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
F3P66_RS06870	COG1063	alcohol dehydrogenase
F3P66_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS06880	COG4948	Mandelate Racemase Muconate Lactonizing
F3P66_RS06890	COG2182	Extracellular solute-binding protein
F3P66_RS06900	COG0395	ABC-type sugar transport system, permease component
F3P66_RS06910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F3P66_RS06915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS06920	COG0765	amino acid transport
F3P66_RS06925	COG0765	amino acid transport
F3P66_RS06930	COG4598	ABC transporter
F3P66_RS06935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F3P66_RS06950	COG0372	Belongs to the citrate synthase family
F3P66_RS06960	COG0765	amino acid transport
F3P66_RS06965	COG0765	amino acid transport
F3P66_RS06975	COG2186	Transcriptional regulator
F3P66_RS06980	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F3P66_RS06985	COG3494	Protein of unknown function (DUF1009)
F3P66_RS06990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F3P66_RS06995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F3P66_RS07000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F3P66_RS07005	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3P66_RS07010	COG0750	zinc metalloprotease
F3P66_RS07020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F3P66_RS07025	COG0233	cytoplasmic translational termination
F3P66_RS07030	COG0528	UMP kinase activity
F3P66_RS07035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F3P66_RS07040	COG0052	Belongs to the universal ribosomal protein uS2 family
F3P66_RS07065	COG0537	adenosine 5'-monophosphoramidase activity
F3P66_RS07095	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F3P66_RS07125	COG3106	COG3106 Predicted ATPase
F3P66_RS07130	COG3768	UPF0283 membrane protein
F3P66_RS07140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F3P66_RS07145	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F3P66_RS07150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F3P66_RS07160	COG0633	Ferredoxin
F3P66_RS07180	COG0384	phenazine biosynthesis protein PhzF
F3P66_RS07185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F3P66_RS07205	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F3P66_RS07220	COG1530	ribonuclease E activity
F3P66_RS07225	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS07245	COG0436	Aminotransferase
F3P66_RS07255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F3P66_RS07260	COG0511	ligase activity, forming carbon-carbon bonds
F3P66_RS07265	COG0439	Biotin carboxylase
F3P66_RS07270	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F3P66_RS07285	COG0456	acetyltransferase
F3P66_RS07295	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F3P66_RS07310	COG3811	Belongs to the UPF0386 family
F3P66_RS07315	COG0456	acetyltransferase
F3P66_RS07320	COG0154	amidase activity
F3P66_RS07325	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F3P66_RS07330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F3P66_RS07335	COG2824	Alkylphosphonate utilization operon protein PhnA
F3P66_RS07340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F3P66_RS07370	COG0456	acetyltransferase
F3P66_RS07375	COG1960	acyl-CoA dehydrogenase activity
F3P66_RS07385	COG0540	Belongs to the ATCase OTCase family
F3P66_RS07395	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F3P66_RS07400	COG0758	DNA mediated transformation
F3P66_RS07410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F3P66_RS07415	COG0557	exoribonuclease II activity
F3P66_RS07430	COG0477	Major facilitator Superfamily
F3P66_RS07435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F3P66_RS07445	COG0784	Response regulator, receiver
F3P66_RS07455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F3P66_RS07470	COG1136	(ABC) transporter
F3P66_RS07480	COG0442	prolyl-tRNA aminoacylation
F3P66_RS07500	COG1007	ATP synthesis coupled electron transport
F3P66_RS07515	COG0713	ATP synthesis coupled electron transport
F3P66_RS07525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3P66_RS07530	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F3P66_RS07540	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F3P66_RS07545	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F3P66_RS07555	COG0649	NAD binding
F3P66_RS07565	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3P66_RS07570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3P66_RS07575	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3P66_RS07610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F3P66_RS07615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F3P66_RS07620	COG0740	serine-type endopeptidase activity
F3P66_RS07625	COG2199	diguanylate cyclase activity
F3P66_RS07630	COG2124	cytochrome p450
F3P66_RS07635	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS07660	COG1832	CoA-binding protein
F3P66_RS07670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F3P66_RS07675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F3P66_RS07680	COG0010	Belongs to the arginase family
F3P66_RS07685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F3P66_RS07695	COG1612	heme a metabolic process
F3P66_RS07720	COG0297	glycogen (starch) synthase activity
F3P66_RS07775	COG3932	Exopolysaccharide synthesis, ExoD
F3P66_RS07805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F3P66_RS07830	COG2897	thiosulfate sulfurtransferase activity
F3P66_RS07855	COG0737	Belongs to the 5'-nucleotidase family
F3P66_RS07860	COG0583	DNA-binding transcription factor activity
F3P66_RS07865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F3P66_RS07880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F3P66_RS07905	COG0444	Belongs to the ABC transporter superfamily
F3P66_RS07910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS07915	COG0601	transmembrane transport
F3P66_RS08010	COG0776	regulation of translation
F3P66_RS08015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F3P66_RS08020	COG0416	fatty acid biosynthetic process
F3P66_RS08040	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F3P66_RS08045	COG2814	Major facilitator Superfamily
F3P66_RS08050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F3P66_RS08055	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F3P66_RS08060	COG1280	lysine exporter protein (LysE YggA)
F3P66_RS08070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F3P66_RS08070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F3P66_RS08075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F3P66_RS08080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F3P66_RS08100	COG0113	porphobilinogen synthase activity
F3P66_RS08110	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
F3P66_RS08115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F3P66_RS08125	COG0659	secondary active sulfate transmembrane transporter activity
F3P66_RS08130	COG4452	Inner membrane protein CreD
F3P66_RS08140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F3P66_RS08145	COG0477	Major facilitator Superfamily
F3P66_RS08150	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F3P66_RS08160	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F3P66_RS08185	COG0248	Ppx GppA phosphatase
F3P66_RS08190	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F3P66_RS08200	COG0628	permease
F3P66_RS08205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F3P66_RS08210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F3P66_RS08225	COG0243	molybdopterin cofactor binding
F3P66_RS08230	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F3P66_RS08245	COG0625	glutathione transferase activity
F3P66_RS08255	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS08260	COG0322	excinuclease ABC activity
F3P66_RS08265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F3P66_RS08270	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F3P66_RS08275	COG0314	molybdopterin synthase activity
F3P66_RS08295	COG0105	UTP biosynthetic process
F3P66_RS08305	COG3706	GGDEF domain
F3P66_RS08310	COG0488	(ABC) transporter
F3P66_RS08325	COG4191	Histidine kinase
F3P66_RS08330	COG3300	MHYT domain
F3P66_RS08330	COG5001	Diguanylate cyclase
F3P66_RS08350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F3P66_RS08365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F3P66_RS08375	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F3P66_RS08380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F3P66_RS08385	COG0400	carboxylic ester hydrolase activity
F3P66_RS08390	COG0194	GDP metabolic process
F3P66_RS08395	COG1561	YicC-like family, N-terminal region
F3P66_RS08400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F3P66_RS08405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F3P66_RS08410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3P66_RS08420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F3P66_RS08425	COG0667	Aldo Keto reductase
F3P66_RS08430	COG0360	Binds together with S18 to 16S ribosomal RNA
F3P66_RS08435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F3P66_RS08445	COG0359	binds to the 23S rRNA
F3P66_RS08465	COG0305	Participates in initiation and elongation during chromosome replication
F3P66_RS08475	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
F3P66_RS08505	COG1286	toxin biosynthetic process
F3P66_RS08510	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F3P66_RS08515	COG4221	oxidoreductase activity
F3P66_RS08520	COG0215	cysteine-tRNA ligase activity
F3P66_RS08525	COG2852	Protein conserved in bacteria
F3P66_RS08560	COG1652	LysM domain
F3P66_RS08565	COG5265	(ABC) transporter
F3P66_RS08570	COG0688	phosphatidylethanolamine metabolic process
F3P66_RS08575	COG1183	phosphatidylcholine synthase activity
F3P66_RS08590	COG1742	UPF0060 membrane protein
F3P66_RS08595	COG1051	belongs to the nudix hydrolase family
F3P66_RS08620	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F3P66_RS08630	COG0668	transmembrane transport
F3P66_RS08635	COG3443	Belongs to the bacterial solute-binding protein 9 family
F3P66_RS08640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3P66_RS08655	COG0346	lactoylglutathione lyase activity
F3P66_RS08665	COG1418	mRNA catabolic process
F3P66_RS08675	COG2226	methyltransferase
F3P66_RS08685	COG1381	Involved in DNA repair and RecF pathway recombination
F3P66_RS08690	COG0784	Response regulator, receiver
F3P66_RS08700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F3P66_RS08705	COG0571	ribonuclease III activity
F3P66_RS08710	COG0681	Belongs to the peptidase S26 family
F3P66_RS08715	COG0736	holo-[acyl-carrier-protein] synthase activity
F3P66_RS08735	COG1758	RNA polymerase activity
F3P66_RS08745	COG0840	transmembrane signaling receptor activity
F3P66_RS08750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F3P66_RS08755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3P66_RS08760	COG0741	lytic transglycosylase activity
F3P66_RS08810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F3P66_RS08840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F3P66_RS08870	COG2814	Major facilitator Superfamily
F3P66_RS08880	COG1968	undecaprenyl-diphosphatase activity
F3P66_RS08885	COG1733	regulation of RNA biosynthetic process
F3P66_RS08890	COG0604	alcohol dehydrogenase
F3P66_RS08930	COG0443	Heat shock 70 kDa protein
F3P66_RS08945	COG0697	spore germination
F3P66_RS08950	COG0308	aminopeptidase N
F3P66_RS08960	COG2202	Pas domain
F3P66_RS08960	COG2205	protein histidine kinase activity
F3P66_RS08965	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F3P66_RS08970	COG3713	MltA-interacting MipA family protein
F3P66_RS08975	COG2205	protein histidine kinase activity
F3P66_RS08985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3P66_RS08990	COG3088	subunit of a heme lyase
F3P66_RS08995	COG1138	Cytochrome C-type biogenesis protein
F3P66_RS09000	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F3P66_RS09005	COG4235	cytochrome complex assembly
F3P66_RS09120	COG4695	Portal protein
F3P66_RS09170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F3P66_RS09175	COG1621	beta-fructofuranosidase activity
F3P66_RS09185	COG2814	Major facilitator Superfamily
F3P66_RS09195	COG2337	Toxic component of a toxin-antitoxin (TA) module
F3P66_RS09225	COG3077	Addiction module antitoxin, RelB DinJ family
F3P66_RS09230	COG3041	Addiction module toxin RelE StbE family
F3P66_RS09240	COG2983	Belongs to the UPF0260 family
F3P66_RS09245	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F3P66_RS09300	COG2205	protein histidine kinase activity
F3P66_RS09310	COG2166	iron-sulfur cluster assembly
F3P66_RS09325	COG4957	zinc ion binding
F3P66_RS09330	COG1320	monovalent cation:proton antiporter activity
F3P66_RS09335	COG2212	antiporter activity
F3P66_RS09340	COG1863	multisubunit Na H antiporter MnhE subunit
F3P66_RS09345	COG0651	ATP synthesis coupled electron transport
F3P66_RS09350	COG1006	Multisubunit Na H antiporter MnhC subunit
F3P66_RS09355	COG2111	Na H antiporter
F3P66_RS09360	COG2111	Na H antiporter
F3P66_RS09360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F3P66_RS09365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F3P66_RS09375	COG1272	protein, Hemolysin III
F3P66_RS09395	COG2514	catechol 2,3-dioxygenase activity
F3P66_RS09405	COG2169	Transcriptional regulator
F3P66_RS09405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F3P66_RS09415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3P66_RS09440	COG4176	ABC-type proline glycine betaine transport system permease component
F3P66_RS09445	COG0517	IMP dehydrogenase activity
F3P66_RS09445	COG4175	Glycine betaine
F3P66_RS09470	COG0789	Transcriptional regulator
F3P66_RS09500	COG2010	Cytochrome c
F3P66_RS09505	COG3909	cytochrome
F3P66_RS09515	COG2378	regulation of single-species biofilm formation
F3P66_RS09525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F3P66_RS09540	COG0583	DNA-binding transcription factor activity
F3P66_RS09545	COG0840	transmembrane signaling receptor activity
F3P66_RS09550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F3P66_RS09555	COG4106	trans-aconitate 2-methyltransferase activity
F3P66_RS09565	COG2378	regulation of single-species biofilm formation
F3P66_RS09570	COG0656	L-ascorbic acid biosynthetic process
F3P66_RS09585	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
F3P66_RS09590	COG1733	regulation of RNA biosynthetic process
F3P66_RS09600	COG0433	COG0433 Predicted ATPase
F3P66_RS09615	COG4221	oxidoreductase activity
F3P66_RS09650	COG0488	(ABC) transporter
F3P66_RS09665	COG1764	response to oxidative stress
F3P66_RS09670	COG1846	Transcriptional regulator
F3P66_RS09675	COG1376	ErfK ybiS ycfS ynhG family protein
F3P66_RS09680	COG1376	ErfK ybiS ycfS ynhG family protein
F3P66_RS09700	COG1793	dna ligase
F3P66_RS09700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F3P66_RS09710	COG0477	Major facilitator Superfamily
F3P66_RS09755	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F3P66_RS09760	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS09765	COG1309	transcriptional regulator
F3P66_RS09775	COG2199	diguanylate cyclase activity
F3P66_RS09775	COG2203	Gaf domain
F3P66_RS09775	COG2200	EAL domain
F3P66_RS09785	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F3P66_RS09790	COG4208	sulfate ABC transporter
F3P66_RS09795	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F3P66_RS09800	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F3P66_RS09805	COG1959	2 iron, 2 sulfur cluster binding
F3P66_RS09810	COG0175	sulfate reduction
F3P66_RS09815	COG0175	sulfate reduction
F3P66_RS09820	COG2895	sulfate adenylyltransferase (ATP) activity
F3P66_RS09835	COG0579	oxidoreductase
F3P66_RS09865	COG1823	symporter activity
F3P66_RS09885	COG2514	catechol 2,3-dioxygenase activity
F3P66_RS09890	COG1196	nuclear chromosome segregation
F3P66_RS09895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F3P66_RS09905	COG1194	a g-specific adenine glycosylase
F3P66_RS09920	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F3P66_RS09935	COG1802	Transcriptional regulator
F3P66_RS09940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F3P66_RS09955	COG0612	Peptidase, M16
F3P66_RS09960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F3P66_RS09980	COG1678	Uncharacterized ACR, COG1678
F3P66_RS09990	COG0678	peroxiredoxin activity
F3P66_RS09990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F3P66_RS10005	COG0328	RNA-DNA hybrid ribonuclease activity
F3P66_RS10010	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F3P66_RS10015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F3P66_RS10020	COG3346	SURF1 family
F3P66_RS10035	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
F3P66_RS10040	COG0109	protoheme IX farnesyltransferase activity
F3P66_RS10045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F3P66_RS10070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F3P66_RS10085	COG0259	pyridoxamine-phosphate oxidase activity
F3P66_RS10100	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F3P66_RS10120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F3P66_RS10125	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3P66_RS10125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3P66_RS10130	COG3214	Protein conserved in bacteria
F3P66_RS10135	COG1122	ATPase activity
F3P66_RS10140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F3P66_RS10145	COG1268	BioY protein
F3P66_RS10150	COG0123	including yeast histone deacetylase and acetoin utilization protein
F3P66_RS10155	COG1722	exodeoxyribonuclease VII activity
F3P66_RS10160	COG1741	Belongs to the pirin family
F3P66_RS10165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F3P66_RS10210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F3P66_RS10215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F3P66_RS10230	COG1960	acyl-CoA dehydrogenase activity
F3P66_RS10255	COG4638	Rieske (2fe-2S)
F3P66_RS10265	COG0009	L-threonylcarbamoyladenylate synthase
F3P66_RS10300	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F3P66_RS10305	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F3P66_RS10315	COG0356	it plays a direct role in the translocation of protons across the membrane
F3P66_RS10330	COG3158	transport of potassium into the cell
F3P66_RS10335	COG0598	Magnesium transport protein CorA
F3P66_RS10345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F3P66_RS10350	COG2197	response regulator
F3P66_RS10360	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS10365	COG3734	2-keto-3-deoxy-galactonokinase
F3P66_RS10370	COG0800	Aldolase
F3P66_RS10375	COG3386	PFAM SMP-30 Gluconolaconase
F3P66_RS10380	COG5001	Diguanylate cyclase
F3P66_RS10380	COG3300	MHYT domain
F3P66_RS10390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F3P66_RS10400	COG1663	tetraacyldisaccharide 4'-kinase activity
F3P66_RS10420	COG0483	inositol monophosphate 1-phosphatase activity
F3P66_RS10425	COG0312	modulator of DNA gyrase
F3P66_RS10435	COG1752	Esterase of the alpha-beta hydrolase superfamily
F3P66_RS10440	COG0742	ribosomal rna small subunit methyltransferase
F3P66_RS10445	COG1187	pseudouridine synthase activity
F3P66_RS10450	COG0590	tRNA wobble adenosine to inosine editing
F3P66_RS10460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F3P66_RS10465	COG0196	riboflavin kinase activity
F3P66_RS10475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F3P66_RS10480	COG0459	protein refolding
F3P66_RS10490	COG2259	Doxx family
F3P66_RS10495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F3P66_RS10500	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F3P66_RS10510	COG0124	histidyl-tRNA synthetase
F3P66_RS10530	COG0583	DNA-binding transcription factor activity
F3P66_RS10535	COG2855	membrane
F3P66_RS10545	COG0519	Catalyzes the synthesis of GMP from XMP
F3P66_RS10550	COG1376	ErfK ybiS ycfS ynhG family protein
F3P66_RS10560	COG0247	lactate metabolic process
F3P66_RS10565	COG0277	FAD linked oxidase domain protein
F3P66_RS10570	COG0277	FAD linked oxidase domain protein
F3P66_RS10575	COG0583	DNA-binding transcription factor activity
F3P66_RS10585	COG2186	Transcriptional regulator
F3P66_RS10595	COG0561	phosphatase activity
F3P66_RS10605	COG0306	phosphate transporter
F3P66_RS10625	COG0583	DNA-binding transcription factor activity
F3P66_RS10640	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F3P66_RS10650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F3P66_RS10655	COG2183	response to ionizing radiation
F3P66_RS10660	COG0151	Belongs to the GarS family
F3P66_RS10670	COG0840	transmembrane signaling receptor activity
F3P66_RS10675	COG1683	Conserved Protein
F3P66_RS10680	COG0751	glycine-tRNA ligase activity
F3P66_RS10690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F3P66_RS10695	COG1704	LemA family
F3P66_RS10705	COG0752	glycyl-tRNA synthetase alpha subunit
F3P66_RS10730	COG0142	geranyltranstransferase activity
F3P66_RS10740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F3P66_RS10745	COG0521	Mo-molybdopterin cofactor biosynthetic process
F3P66_RS10790	COG0477	Major facilitator Superfamily
F3P66_RS10795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F3P66_RS10800	COG0248	Ppx GppA phosphatase
F3P66_RS10810	COG2205	protein histidine kinase activity
F3P66_RS10820	COG1177	transmembrane transport
F3P66_RS10825	COG1176	ABC-type spermidine putrescine transport system, permease component I
F3P66_RS10830	COG3842	ATPase activity
F3P66_RS10845	COG2224	Isocitrate lyase
F3P66_RS10860	COG2081	HI0933 family
F3P66_RS10870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS10875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F3P66_RS10880	COG0363	glucosamine-6-phosphate deaminase activity
F3P66_RS10885	COG0129	dihydroxy-acid dehydratase activity
F3P66_RS10900	COG3842	ATPase activity
F3P66_RS10910	COG0395	ABC-type sugar transport system, permease component
F3P66_RS10915	COG1175	transmembrane transport
F3P66_RS10920	COG1653	transport
F3P66_RS10925	COG1609	Transcriptional regulator
F3P66_RS10930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F3P66_RS10970	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F3P66_RS10980	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F3P66_RS10985	COG5443	negative regulation of bacterial-type flagellum assembly
F3P66_RS11005	COG1749	Flagellar hook protein flgE
F3P66_RS11030	COG1360	Flagellar Motor Protein
F3P66_RS11050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F3P66_RS11055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F3P66_RS11060	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F3P66_RS11065	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F3P66_RS11070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F3P66_RS11080	COG4786	Flagellar basal body rod
F3P66_RS11085	COG1157	protein secretion by the type III secretion system
F3P66_RS11095	COG1815	bacterial-type flagellum-dependent cell motility
F3P66_RS11100	COG1558	bacterial-type flagellum-dependent cell motility
F3P66_RS11105	COG1677	Flagellar hook-basal body complex protein FliE
F3P66_RS11110	COG4786	Flagellar basal body rod
F3P66_RS11115	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
F3P66_RS11120	COG1706	bacterial-type flagellum-dependent cell motility
F3P66_RS11130	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F3P66_RS11140	COG1338	Plays a role in the flagellum-specific transport system
F3P66_RS11160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F3P66_RS11175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F3P66_RS11190	COG5328	Belongs to the UPF0262 family
F3P66_RS11200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F3P66_RS11205	COG0424	maF-like protein
F3P66_RS11210	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F3P66_RS11225	COG0436	Aminotransferase
F3P66_RS11230	COG1970	mechanosensitive ion channel activity
F3P66_RS11235	COG2198	Histidine kinase
F3P66_RS11235	COG2205	protein histidine kinase activity
F3P66_RS11235	COG0784	Response regulator, receiver
F3P66_RS11240	COG2972	Histidine kinase
F3P66_RS11240	COG0840	transmembrane signaling receptor activity
F3P66_RS11250	COG2771	luxR family
F3P66_RS11255	COG1766	The M ring may be actively involved in energy transduction
F3P66_RS11265	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
F3P66_RS11270	COG0745	RESPONSE REGULATOR receiver
F3P66_RS11275	COG2201	protein-glutamate methylesterase activity
F3P66_RS11280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F3P66_RS11285	COG2198	Histidine kinase
F3P66_RS11285	COG0643	Histidine kinase
F3P66_RS11290	COG0745	RESPONSE REGULATOR receiver
F3P66_RS11300	COG0840	transmembrane signaling receptor activity
F3P66_RS11310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F3P66_RS11310	COG2111	Na H antiporter
F3P66_RS11315	COG1006	Multisubunit Na H antiporter MnhC subunit
F3P66_RS11320	COG0651	ATP synthesis coupled electron transport
F3P66_RS11325	COG1863	multisubunit Na H antiporter MnhE subunit
F3P66_RS11330	COG2212	antiporter activity
F3P66_RS11335	COG1320	monovalent cation:proton antiporter activity
F3P66_RS11355	COG1024	Enoyl-CoA hydratase
F3P66_RS11355	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3P66_RS11360	COG0183	Belongs to the thiolase family
F3P66_RS11365	COG1960	acyl-CoA dehydrogenase activity
F3P66_RS11375	COG0730	response to heat
F3P66_RS11395	COG1201	RNA secondary structure unwinding
F3P66_RS11400	COG1959	2 iron, 2 sulfur cluster binding
F3P66_RS11420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F3P66_RS11435	COG0167	dihydroorotate dehydrogenase activity
F3P66_RS11485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F3P66_RS11505	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
F3P66_RS11740	COG0717	Belongs to the dCTP deaminase family
F3P66_RS11750	COG2967	ApaG domain
F3P66_RS11760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F3P66_RS11765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F3P66_RS11775	COG0745	RESPONSE REGULATOR receiver
F3P66_RS11780	COG0704	Plays a role in the regulation of phosphate uptake
F3P66_RS11785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F3P66_RS11795	COG0573	inorganic phosphate transmembrane transporter activity
F3P66_RS11800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F3P66_RS11805	COG5002	protein histidine kinase activity
F3P66_RS11810	COG2326	polyphosphate kinase activity
F3P66_RS11850	COG4774	siderophore transport
F3P66_RS11855	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F3P66_RS11860	COG1840	ABC-type Fe3 transport system, periplasmic component
F3P66_RS11865	COG3842	ATPase activity
F3P66_RS11870	COG0318	PFAM AMP-dependent synthetase and ligase
F3P66_RS11875	COG0166	Belongs to the GPI family
F3P66_RS11895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F3P66_RS11900	COG0418	dihydroorotase activity
F3P66_RS11905	COG3938	Belongs to the proline racemase family
F3P66_RS11915	COG0427	acetyl-CoA hydrolase
F3P66_RS11930	COG0395	ABC-type sugar transport system, permease component
F3P66_RS11935	COG1175	transmembrane transport
F3P66_RS11940	COG3842	ATPase activity
F3P66_RS11945	COG2226	methyltransferase
F3P66_RS11955	COG5002	protein histidine kinase activity
F3P66_RS11955	COG3850	Histidine kinase
F3P66_RS11960	COG0840	transmembrane signaling receptor activity
F3P66_RS11965	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F3P66_RS11970	COG0594	ribonuclease P activity
F3P66_RS11975	COG0706	membrane insertase activity
F3P66_RS11980	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F3P66_RS11990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F3P66_RS12015	COG0071	Belongs to the small heat shock protein (HSP20) family
F3P66_RS12025	COG0840	transmembrane signaling receptor activity
F3P66_RS12035	COG2171	N-acyltransferase activity
F3P66_RS12040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3P66_RS12050	COG0101	tRNA pseudouridine synthase activity
F3P66_RS12055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F3P66_RS12060	COG0242	peptide deformylase activity
F3P66_RS12070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3P66_RS12075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F3P66_RS12080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F3P66_RS12085	COG1396	sequence-specific DNA binding
F3P66_RS12090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F3P66_RS12100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F3P66_RS12105	COG1702	phosphate starvation-inducible protein PhoH
F3P66_RS12110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F3P66_RS12135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F3P66_RS12145	COG0180	Tryptophanyl-tRNA synthetase
F3P66_RS12160	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F3P66_RS12165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F3P66_RS12180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F3P66_RS12185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F3P66_RS12200	COG0776	regulation of translation
F3P66_RS12205	COG0616	signal peptide processing
F3P66_RS12215	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F3P66_RS12220	COG1137	ATPase activity
F3P66_RS12230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F3P66_RS12235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F3P66_RS12240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F3P66_RS12245	COG1420	regulation of RNA biosynthetic process
F3P66_RS12250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F3P66_RS12255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F3P66_RS12260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F3P66_RS12265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F3P66_RS12270	COG0268	Binds directly to 16S ribosomal RNA
F3P66_RS12275	COG1024	Enoyl-CoA hydratase
F3P66_RS12280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F3P66_RS12285	COG2226	methyltransferase
F3P66_RS12290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F3P66_RS12305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F3P66_RS12310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F3P66_RS12315	COG0756	dUTP diphosphatase activity
F3P66_RS12320	COG1280	lysine exporter protein (LysE YggA)
F3P66_RS12325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F3P66_RS12330	COG0606	chelatase, subunit chli
F3P66_RS12335	COG0189	ligase activity
F3P66_RS12345	COG3842	ATPase activity
F3P66_RS12350	COG0395	ABC-type sugar transport system, permease component
F3P66_RS12355	COG1175	transmembrane transport
F3P66_RS12370	COG0792	nuclease activity
F3P66_RS12375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F3P66_RS12385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F3P66_RS12395	COG0284	orotidine-5'-phosphate decarboxylase activity
F3P66_RS12415	COG1968	undecaprenyl-diphosphatase activity
F3P66_RS12425	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F3P66_RS12435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F3P66_RS12465	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
F3P66_RS12480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F3P66_RS12480	COG0519	Catalyzes the synthesis of GMP from XMP
F3P66_RS12490	COG1309	transcriptional regulator
F3P66_RS12505	COG1393	Belongs to the ArsC family
F3P66_RS12510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F3P66_RS12515	COG2309	aminopeptidase activity
F3P66_RS12520	COG0697	spore germination
F3P66_RS12525	COG1846	Transcriptional regulator
F3P66_RS12535	COG4948	Mandelate Racemase Muconate Lactonizing
F3P66_RS12540	COG1570	exodeoxyribonuclease VII activity
F3P66_RS12565	COG4977	sequence-specific DNA binding
F3P66_RS12570	COG0667	Aldo Keto reductase
F3P66_RS12585	COG0667	Aldo Keto reductase
F3P66_RS12590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3P66_RS12590	COG0072	phenylalanine-tRNA ligase activity
F3P66_RS12595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F3P66_RS12605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F3P66_RS12610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F3P66_RS12615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F3P66_RS12640	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F3P66_RS12645	COG2169	Transcriptional regulator
F3P66_RS12645	COG1917	Cupin 2, conserved barrel domain protein
F3P66_RS12660	COG1396	sequence-specific DNA binding
F3P66_RS12675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F3P66_RS12680	COG0481	GTPase activity
F3P66_RS12710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3P66_RS12715	COG0697	spore germination
F3P66_RS12720	COG3757	hydrolase, family 25
F3P66_RS12725	COG3422	double-strand break repair
F3P66_RS12770	COG4964	Belongs to the GSP D family
F3P66_RS12805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F3P66_RS12810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F3P66_RS12820	COG0791	NLP P60 protein
F3P66_RS12835	COG0697	spore germination
F3P66_RS12855	COG4269	membrane
F3P66_RS12865	COG1840	ABC-type Fe3 transport system, periplasmic component
F3P66_RS12870	COG1959	2 iron, 2 sulfur cluster binding
F3P66_RS12880	COG1732	Glycine betaine
F3P66_RS12885	COG1174	glycine betaine transport
F3P66_RS12890	COG1125	glycine betaine transport
F3P66_RS12895	COG1174	glycine betaine transport
F3P66_RS12900	COG3265	gluconokinase activity
F3P66_RS12905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS12910	COG0174	glutamine synthetase
F3P66_RS12920	COG4172	Belongs to the ABC transporter superfamily
F3P66_RS12925	COG4239	(ABC) transporter, permease
F3P66_RS12930	COG4174	ABC transporter (Permease)
F3P66_RS12935	COG4166	transmembrane transport
F3P66_RS12945	COG1803	Methylglyoxal synthase
F3P66_RS12950	COG0837	glucose binding
F3P66_RS12955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F3P66_RS12960	COG2188	Transcriptional regulator
F3P66_RS12965	COG3624	Phosphonate C-P lyase system protein PhnG
F3P66_RS12970	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
F3P66_RS12975	COG3626	phosphonate metabolism
F3P66_RS12980	COG3627	carbon phosphorus lyase activity
F3P66_RS12985	COG4107	phosphonate C-P lyase system protein PhnK
F3P66_RS12990	COG4778	phosphonate C-P lyase system protein PhnL
F3P66_RS13000	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
F3P66_RS13005	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
F3P66_RS13010	COG3639	organic phosphonate transmembrane transporter activity
F3P66_RS13015	COG3639	organic phosphonate transmembrane transporter activity
F3P66_RS13020	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
F3P66_RS13025	COG3454	Phosphonate metabolism
F3P66_RS13030	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
F3P66_RS13045	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F3P66_RS13055	COG0848	biopolymer transport protein
F3P66_RS13075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3P66_RS13105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F3P66_RS13115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F3P66_RS13130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F3P66_RS13135	COG0070	glutamate synthase
F3P66_RS13135	COG0067	glutamate synthase
F3P66_RS13135	COG0069	glutamate synthase activity
F3P66_RS13140	COG0477	Major facilitator Superfamily
F3P66_RS13150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F3P66_RS13155	COG1845	cytochrome c oxidase, subunit III
F3P66_RS13160	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F3P66_RS13170	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F3P66_RS13175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F3P66_RS13180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F3P66_RS13190	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F3P66_RS13195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F3P66_RS13200	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F3P66_RS13205	COG0295	cytidine deaminase activity
F3P66_RS13210	COG1079	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS13220	COG3845	ABC transporter
F3P66_RS13225	COG1744	ABC transporter substrate-binding protein PnrA-like
F3P66_RS13230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F3P66_RS13245	COG0443	Heat shock 70 kDa protein
F3P66_RS13250	COG0484	heat shock protein binding
F3P66_RS13260	COG2900	Belongs to the SlyX family
F3P66_RS13290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F3P66_RS13300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3P66_RS13300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3P66_RS13315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3P66_RS13320	COG1278	Cold shock
F3P66_RS13325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F3P66_RS13330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F3P66_RS13345	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F3P66_RS13350	COG0077	Prephenate dehydratase
F3P66_RS13350	COG1605	Chorismate mutase
F3P66_RS13355	COG2816	NAD+ diphosphatase activity
F3P66_RS13370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F3P66_RS13375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F3P66_RS13385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F3P66_RS13390	COG2951	lytic endotransglycosylase activity
F3P66_RS13395	COG2814	Major facilitator Superfamily
F3P66_RS13400	COG0779	Required for maturation of 30S ribosomal subunits
F3P66_RS13415	COG3064	Membrane
F3P66_RS13415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F3P66_RS13420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F3P66_RS13425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F3P66_RS13430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F3P66_RS13435	COG1185	polyribonucleotide nucleotidyltransferase activity
F3P66_RS13440	COG2813	Specifically methylates the guanine in position
F3P66_RS13450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3P66_RS13480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F3P66_RS13500	COG1780	Probably involved in ribonucleotide reductase function
F3P66_RS13510	COG1072	(Pantothenic acid kinase))
F3P66_RS13580	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
F3P66_RS13595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F3P66_RS13605	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F3P66_RS13610	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F3P66_RS13615	COG0131	Imidazoleglycerol-phosphate dehydratase
F3P66_RS13625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F3P66_RS13630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F3P66_RS13635	COG0107	imidazoleglycerol-phosphate synthase activity
F3P66_RS13640	COG0140	phosphoribosyl-ATP diphosphatase activity
F3P66_RS13645	COG1072	(Pantothenic acid kinase))
F3P66_RS13655	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F3P66_RS13660	COG0745	RESPONSE REGULATOR receiver
F3P66_RS13665	COG0642	Histidine kinase
F3P66_RS13670	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F3P66_RS13675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F3P66_RS13675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F3P66_RS13680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F3P66_RS13685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F3P66_RS13690	COG2205	protein histidine kinase activity
F3P66_RS13700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F3P66_RS13725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F3P66_RS13730	COG0159	tryptophan synthase activity
F3P66_RS13735	COG0133	tryptophan synthase activity
F3P66_RS13740	COG0135	phosphoribosylanthranilate isomerase activity
F3P66_RS13755	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3P66_RS13780	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F3P66_RS13790	COG3030	protein affecting phage T7 exclusion by the F plasmid
F3P66_RS13795	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F3P66_RS13805	COG0237	dephospho-CoA kinase activity
F3P66_RS13810	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F3P66_RS13815	COG0424	maF-like protein
F3P66_RS13820	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F3P66_RS13825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F3P66_RS13830	COG1981	membrane
F3P66_RS13835	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F3P66_RS13840	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F3P66_RS13845	COG0445	tRNA wobble uridine modification
F3P66_RS13850	COG0357	Ribosomal RNA small subunit methyltransferase G
F3P66_RS13870	COG0501	Belongs to the peptidase M48B family
F3P66_RS13875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F3P66_RS13875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F3P66_RS13970	COG4948	Mandelate Racemase Muconate Lactonizing
F3P66_RS14005	COG0601	transmembrane transport
F3P66_RS14010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS14030	COG0747	negative chemotaxis
F3P66_RS14060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS14065	COG0601	transmembrane transport
F3P66_RS14120	COG4178	(ABC) transporter
F3P66_RS14130	COG1609	Transcriptional regulator
F3P66_RS14145	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS14150	COG1735	metal-dependent hydrolase with the TIM-barrel fold
F3P66_RS14185	COG1794	racemase activity, acting on amino acids and derivatives
F3P66_RS14190	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS14195	COG1309	transcriptional regulator
F3P66_RS14200	COG2233	PERMEase
F3P66_RS14240	COG1595	DNA-templated transcription, initiation
F3P66_RS14250	COG0395	ABC-type sugar transport system, permease component
F3P66_RS14255	COG1176	ABC-type spermidine putrescine transport system, permease component I
F3P66_RS14265	COG3842	ATPase activity
F3P66_RS14300	COG1653	transport
F3P66_RS14310	COG0395	ABC-type sugar transport system, permease component
F3P66_RS14315	COG3842	ATPase activity
F3P66_RS14320	COG0395	ABC-type sugar transport system, permease component
F3P66_RS14325	COG1175	transmembrane transport
F3P66_RS14355	COG1609	Transcriptional regulator
F3P66_RS14365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F3P66_RS14370	COG1082	Xylose isomerase domain protein TIM barrel
F3P66_RS14375	COG3842	ATPase activity
F3P66_RS14380	COG0395	ABC-type sugar transport system, permease component
F3P66_RS14385	COG1175	transmembrane transport
F3P66_RS14390	COG1653	transport
F3P66_RS14395	COG1309	transcriptional regulator
F3P66_RS14400	COG0673	inositol 2-dehydrogenase activity
F3P66_RS14415	COG0673	inositol 2-dehydrogenase activity
F3P66_RS14425	COG1278	Cold shock
F3P66_RS14435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F3P66_RS14460	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
F3P66_RS14475	COG3842	ATPase activity
F3P66_RS14480	COG0395	ABC-type sugar transport system, permease component
F3P66_RS14485	COG1175	transmembrane transport
F3P66_RS14505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F3P66_RS14510	COG3618	amidohydrolase
F3P66_RS14515	COG4948	Mandelate Racemase Muconate Lactonizing
F3P66_RS14520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3P66_RS14525	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS14530	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
F3P66_RS14540	COG2186	Transcriptional regulator
F3P66_RS14590	COG2223	nitrite transmembrane transporter activity
F3P66_RS14595	COG0583	DNA-binding transcription factor activity
F3P66_RS14600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F3P66_RS14610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F3P66_RS14615	COG2084	Dehydrogenase
F3P66_RS14630	COG1609	Transcriptional regulator
F3P66_RS14635	COG1063	alcohol dehydrogenase
F3P66_RS14640	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS14650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3P66_RS14655	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
F3P66_RS14660	COG1175	transmembrane transport
F3P66_RS14665	COG0395	ABC-type sugar transport system, permease component
F3P66_RS14680	COG0395	ABC-type sugar transport system, permease component
F3P66_RS14685	COG1175	transmembrane transport
F3P66_RS14690	COG2182	Extracellular solute-binding protein
F3P66_RS14695	COG0626	cystathionine gamma-synthase activity
F3P66_RS14710	COG0803	Belongs to the bacterial solute-binding protein 9 family
F3P66_RS14720	COG1121	(ABC) transporter
F3P66_RS14725	COG0523	cobalamin synthesis protein
F3P66_RS14740	COG0523	cobalamin synthesis protein
F3P66_RS14745	COG1653	transport
F3P66_RS14750	COG1175	transmembrane transport
F3P66_RS14755	COG0395	ABC-type sugar transport system, permease component
F3P66_RS14760	COG3842	ATPase activity
F3P66_RS14775	COG3047	cAMP biosynthetic process
F3P66_RS14800	COG0583	DNA-binding transcription factor activity
F3P66_RS14805	COG1879	ABC-type sugar transport system periplasmic component
F3P66_RS14810	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS14815	COG1129	ABC transporter
F3P66_RS14825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F3P66_RS14830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F3P66_RS14835	COG3447	MASE1 domain protein
F3P66_RS14835	COG5002	protein histidine kinase activity
F3P66_RS14835	COG5001	Diguanylate cyclase
F3P66_RS14840	COG3257	ureidoglycine aminohydrolase activity
F3P66_RS14850	COG5001	Diguanylate cyclase
F3P66_RS14870	COG0747	negative chemotaxis
F3P66_RS14875	COG0601	transmembrane transport
F3P66_RS14880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS14890	COG4608	Belongs to the ABC transporter superfamily
F3P66_RS14895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F3P66_RS14905	COG0129	dihydroxy-acid dehydratase activity
F3P66_RS14915	COG1879	ABC-type sugar transport system periplasmic component
F3P66_RS14920	COG1129	ABC transporter
F3P66_RS14925	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS14930	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS14935	COG2186	Transcriptional regulator
F3P66_RS14945	COG0587	DNA-directed DNA polymerase activity
F3P66_RS14985	COG3842	ATPase activity
F3P66_RS14990	COG0395	ABC-type sugar transport system, permease component
F3P66_RS14995	COG1175	transmembrane transport
F3P66_RS15000	COG1653	transport
F3P66_RS15010	COG0673	inositol 2-dehydrogenase activity
F3P66_RS15025	COG5001	Diguanylate cyclase
F3P66_RS15030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS15040	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F3P66_RS15045	COG2894	cell division
F3P66_RS15050	COG0850	regulation of cytokinetic process
F3P66_RS15055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F3P66_RS15060	COG2186	Transcriptional regulator
F3P66_RS15065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F3P66_RS15075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F3P66_RS15085	COG1312	Catalyzes the dehydration of D-mannonate
F3P66_RS15100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F3P66_RS15105	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F3P66_RS15110	COG4172	Belongs to the ABC transporter superfamily
F3P66_RS15115	COG1921	L-seryl-tRNASec selenium transferase activity
F3P66_RS15130	COG3964	amidohydrolase
F3P66_RS15140	COG0601	transmembrane transport
F3P66_RS15145	COG0747	negative chemotaxis
F3P66_RS15150	COG0438	transferase activity, transferring glycosyl groups
F3P66_RS15185	COG4989	oxidoreductase activity
F3P66_RS15200	COG3842	ATPase activity
F3P66_RS15205	COG1653	transport
F3P66_RS15210	COG1175	transmembrane transport
F3P66_RS15215	COG0395	ABC-type sugar transport system, permease component
F3P66_RS15220	COG1501	Belongs to the glycosyl hydrolase 31 family
F3P66_RS15225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3P66_RS15230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F3P66_RS15235	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
F3P66_RS15240	COG0352	thiamine-phosphate diphosphorylase activity
F3P66_RS15245	COG0351	phosphomethylpyrimidine kinase
F3P66_RS15250	COG1522	sequence-specific DNA binding
F3P66_RS15255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F3P66_RS15260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS15275	COG2204	response regulator
F3P66_RS15280	COG4191	Histidine kinase
F3P66_RS15285	COG1301	dicarboxylic acid transport
F3P66_RS15295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3P66_RS15300	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS15310	COG1473	amidohydrolase
F3P66_RS15330	COG1215	transferase activity, transferring glycosyl groups
F3P66_RS15340	COG2942	2-epimerase
F3P66_RS15405	COG3307	-O-antigen
F3P66_RS15410	COG1596	polysaccharide export
F3P66_RS15415	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F3P66_RS15425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3P66_RS15430	COG0840	transmembrane signaling receptor activity
F3P66_RS15435	COG1388	LysM domain
F3P66_RS15435	COG1376	ErfK ybiS ycfS ynhG family protein
F3P66_RS15445	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS15455	COG2094	Belongs to the DNA glycosylase MPG family
F3P66_RS15475	COG1653	transport
F3P66_RS15490	COG3842	ATPase activity
F3P66_RS15500	COG0673	inositol 2-dehydrogenase activity
F3P66_RS15505	COG0602	queuosine metabolic process
F3P66_RS15510	COG0720	synthase
F3P66_RS15515	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F3P66_RS15520	COG0673	inositol 2-dehydrogenase activity
F3P66_RS15535	COG0395	ABC-type sugar transport system, permease component
F3P66_RS15540	COG1175	transmembrane transport
F3P66_RS15560	COG0583	DNA-binding transcription factor activity
F3P66_RS15565	COG0280	phosphate acetyltransferase
F3P66_RS15565	COG0281	malic enzyme
F3P66_RS15580	COG0765	amino acid transport
F3P66_RS15585	COG1126	abc transporter atp-binding protein
F3P66_RS15595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS15620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F3P66_RS15625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F3P66_RS15630	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F3P66_RS15635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F3P66_RS15640	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS15645	COG1129	ABC transporter
F3P66_RS15675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS15680	COG0601	transmembrane transport
F3P66_RS15685	COG0583	DNA-binding transcription factor activity
F3P66_RS15690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F3P66_RS15695	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
F3P66_RS15715	COG1595	DNA-templated transcription, initiation
F3P66_RS15720	COG1120	ATPase activity
F3P66_RS15725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3P66_RS15740	COG2226	methyltransferase
F3P66_RS15750	COG1120	ATPase activity
F3P66_RS15755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3P66_RS15775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3P66_RS15785	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS15790	COG0473	3-isopropylmalate dehydrogenase activity
F3P66_RS15795	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS15800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS15830	COG0601	transmembrane transport
F3P66_RS15835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS15840	COG4172	Belongs to the ABC transporter superfamily
F3P66_RS15845	COG1522	sequence-specific DNA binding
F3P66_RS15850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS15860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS15865	COG1126	abc transporter atp-binding protein
F3P66_RS15875	COG1473	amidohydrolase
F3P66_RS15880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS15885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS15890	COG1959	2 iron, 2 sulfur cluster binding
F3P66_RS15905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS15920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS15925	COG1960	acyl-CoA dehydrogenase activity
F3P66_RS15960	COG0667	Aldo Keto reductase
F3P66_RS15970	COG0583	DNA-binding transcription factor activity
F3P66_RS15975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS15995	COG1473	amidohydrolase
F3P66_RS16000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS16015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS16020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS16040	COG4608	Belongs to the ABC transporter superfamily
F3P66_RS16045	COG0444	Belongs to the ABC transporter superfamily
F3P66_RS16055	COG0601	transmembrane transport
F3P66_RS16065	COG2186	Transcriptional regulator
F3P66_RS16090	COG3453	Protein conserved in bacteria
F3P66_RS16090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F3P66_RS16095	COG0640	Transcriptional regulator
F3P66_RS16105	COG2391	methyltransferase activity
F3P66_RS16110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F3P66_RS16120	COG0022	dehydrogenase e1 component
F3P66_RS16130	COG1960	acyl-CoA dehydrogenase activity
F3P66_RS16135	COG0183	Belongs to the thiolase family
F3P66_RS16145	COG1960	acyl-CoA dehydrogenase activity
F3P66_RS16150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3P66_RS16165	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F3P66_RS16170	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F3P66_RS16175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F3P66_RS16180	COG4952	isomerase
F3P66_RS16185	COG3347	Dehydrogenase
F3P66_RS16185	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS16190	COG1349	DNA-binding transcription factor activity
F3P66_RS16200	COG1129	ABC transporter
F3P66_RS16205	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS16215	COG3254	rhamnose metabolic process
F3P66_RS16230	COG2264	protein methyltransferase activity
F3P66_RS16235	COG5001	Diguanylate cyclase
F3P66_RS16255	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F3P66_RS16260	COG4208	sulfate ABC transporter
F3P66_RS16270	COG4150	thiosulfate binding
F3P66_RS16290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F3P66_RS16300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F3P66_RS16310	COG1040	competence protein
F3P66_RS16315	COG2226	methyltransferase
F3P66_RS16330	COG0494	nUDIX hydrolase
F3P66_RS16340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F3P66_RS16345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F3P66_RS16350	COG0653	protein targeting
F3P66_RS16355	COG0697	spore germination
F3P66_RS16395	COG1312	Catalyzes the dehydration of D-mannonate
F3P66_RS16400	COG0246	Mannitol dehydrogenase
F3P66_RS16420	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS16425	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS16430	COG1129	ABC transporter
F3P66_RS16460	COG2376	Dihydroxyacetone kinase
F3P66_RS16465	COG0471	metal ion transport
F3P66_RS16465	COG3273	potassium ion transport
F3P66_RS16485	COG0438	transferase activity, transferring glycosyl groups
F3P66_RS16495	COG2244	polysaccharide biosynthetic process
F3P66_RS16520	COG0489	protein tyrosine kinase activity
F3P66_RS16520	COG3206	protein involved in exopolysaccharide biosynthesis
F3P66_RS16545	COG0438	transferase activity, transferring glycosyl groups
F3P66_RS16560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F3P66_RS16565	COG2273	Hydrolase Family 16
F3P66_RS16565	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
F3P66_RS16610	COG1396	sequence-specific DNA binding
F3P66_RS16620	COG1129	ABC transporter
F3P66_RS16625	COG4214	carbohydrate transport
F3P66_RS16630	COG4213	ABC transporter substrate-binding protein
F3P66_RS16645	COG0346	lactoylglutathione lyase activity
F3P66_RS16650	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3P66_RS16650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F3P66_RS16655	COG4770	biotin carboxylase activity
F3P66_RS16665	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
F3P66_RS16675	COG0625	glutathione transferase activity
F3P66_RS16680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3P66_RS16685	COG3800	Transcriptional regulator
F3P66_RS16685	COG1396	sequence-specific DNA binding
F3P66_RS16695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F3P66_RS16705	COG0300	oxidoreductase activity
F3P66_RS16715	COG2096	Adenosyltransferase
F3P66_RS16725	COG2086	electron transfer activity
F3P66_RS16735	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3P66_RS16740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F3P66_RS16745	COG0165	Argininosuccinate lyase
F3P66_RS16780	COG2884	Cell division ATP-binding protein ftsE
F3P66_RS16800	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
F3P66_RS16810	COG0287	Prephenate dehydrogenase
F3P66_RS16815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F3P66_RS16820	COG2226	methyltransferase
F3P66_RS16825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F3P66_RS16845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F3P66_RS16850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F3P66_RS16885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F3P66_RS16890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F3P66_RS16900	COG4974	Belongs to the 'phage' integrase family
F3P66_RS16905	COG0825	malonyl-CoA metabolic process
F3P66_RS16910	COG3034	peptidoglycan biosynthetic process
F3P66_RS16915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3P66_RS16915	COG0425	Belongs to the sulfur carrier protein TusA family
F3P66_RS16920	COG0523	cobalamin synthesis protein
F3P66_RS16925	COG1686	Belongs to the peptidase S11 family
F3P66_RS16930	COG1473	amidohydrolase
F3P66_RS16940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F3P66_RS17010	COG0456	acetyltransferase
F3P66_RS17045	COG2267	carboxylic ester hydrolase activity
F3P66_RS17055	COG1959	2 iron, 2 sulfur cluster binding
F3P66_RS17060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F3P66_RS17100	COG2226	methyltransferase
F3P66_RS17135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F3P66_RS17155	COG1629	transport
F3P66_RS17155	COG4774	siderophore transport
F3P66_RS17160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F3P66_RS17165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3P66_RS17170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3P66_RS17175	COG1120	ATPase activity
F3P66_RS17190	COG4953	penicillin-binding protein 1C
F3P66_RS17195	COG2373	Large extracellular alpha-helical protein
F3P66_RS17200	COG2835	tetraacyldisaccharide 4'-kinase activity
F3P66_RS17210	COG3118	belongs to the thioredoxin family
F3P66_RS17225	COG0625	glutathione transferase activity
F3P66_RS17235	COG0482	sulfurtransferase activity
F3P66_RS17250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3P66_RS17265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F3P66_RS17270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F3P66_RS17275	COG0037	tRNA processing
F3P66_RS17285	COG2885	chlorophyll binding
F3P66_RS17290	COG0823	Involved in the tonB-independent uptake of proteins
F3P66_RS17310	COG0824	Thioesterase
F3P66_RS17320	COG0494	nUDIX hydrolase
F3P66_RS17335	COG2255	four-way junction helicase activity
F3P66_RS17340	COG0632	four-way junction helicase activity
F3P66_RS17345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F3P66_RS17350	COG0840	transmembrane signaling receptor activity
F3P66_RS17355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS17360	COG0217	transcriptional regulatory protein
F3P66_RS17375	COG1692	metallophosphoesterase
F3P66_RS17385	COG1253	flavin adenine dinucleotide binding
F3P66_RS17415	COG3263	regulation of cellular component size
F3P66_RS17420	COG0126	phosphoglycerate kinase activity
F3P66_RS17425	COG3588	fructose-bisphosphate aldolase
F3P66_RS17450	COG0254	rRNA binding
F3P66_RS17455	COG1132	(ABC) transporter
F3P66_RS17475	COG0483	inositol monophosphate 1-phosphatase activity
F3P66_RS17505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F3P66_RS17510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F3P66_RS17515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F3P66_RS17525	COG3750	Belongs to the UPF0335 family
F3P66_RS17545	COG0469	pyruvate kinase activity
F3P66_RS17550	COG3108	Peptidase M15
F3P66_RS17555	COG2204	response regulator
F3P66_RS17560	COG1164	Oligoendopeptidase f
F3P66_RS17565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F3P66_RS17575	COG5310	Homospermidine synthase
F3P66_RS17585	COG0737	Belongs to the 5'-nucleotidase family
F3P66_RS17590	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F3P66_RS17595	COG0330	HflC and HflK could
F3P66_RS17620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F3P66_RS17625	COG2951	lytic endotransglycosylase activity
F3P66_RS17640	COG2205	protein histidine kinase activity
F3P66_RS17655	COG0069	glutamate synthase activity
F3P66_RS17655	COG0070	glutamate synthase
F3P66_RS17655	COG0067	glutamate synthase
F3P66_RS17665	COG0745	RESPONSE REGULATOR receiver
F3P66_RS17670	COG2205	protein histidine kinase activity
F3P66_RS17675	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F3P66_RS17680	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F3P66_RS17690	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F3P66_RS17700	COG0252	asparaginase activity
F3P66_RS17710	COG1027	Aspartate ammonia-lyase
F3P66_RS17715	COG2186	Transcriptional regulator
F3P66_RS17750	COG4176	ABC-type proline glycine betaine transport system permease component
F3P66_RS17755	COG0517	IMP dehydrogenase activity
F3P66_RS17755	COG4175	Glycine betaine
F3P66_RS17760	COG2986	histidine ammonia-lyase
F3P66_RS17765	COG2814	Major facilitator Superfamily
F3P66_RS17780	COG1522	sequence-specific DNA binding
F3P66_RS17785	COG0583	DNA-binding transcription factor activity
F3P66_RS17790	COG0667	Aldo Keto reductase
F3P66_RS17800	COG1335	isochorismatase
F3P66_RS17810	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS17815	COG3254	rhamnose metabolic process
F3P66_RS17830	COG2721	sulfolactate sulfo-lyase activity
F3P66_RS17835	COG1129	ABC transporter
F3P66_RS17845	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS17850	COG1879	ABC-type sugar transport system periplasmic component
F3P66_RS17885	COG0583	DNA-binding transcription factor activity
F3P66_RS18040	COG2308	Evidence 4 Homologs of previously reported genes of
F3P66_RS18040	COG2307	Protein conserved in bacteria
F3P66_RS18055	COG0488	(ABC) transporter
F3P66_RS18060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F3P66_RS18065	COG1304	FMN binding
F3P66_RS18090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F3P66_RS18095	COG0667	Aldo Keto reductase
F3P66_RS18105	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS18110	COG1129	ABC transporter
F3P66_RS18115	COG1879	ABC-type sugar transport system periplasmic component
F3P66_RS18165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F3P66_RS18180	COG0395	ABC-type sugar transport system, permease component
F3P66_RS18195	COG3842	ATPase activity
F3P66_RS18215	COG0243	molybdopterin cofactor binding
F3P66_RS18225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F3P66_RS18230	COG1116	anion transmembrane transporter activity
F3P66_RS18235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3P66_RS18240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F3P66_RS18250	COG3707	response regulator
F3P66_RS18255	COG1802	Transcriptional regulator
F3P66_RS18260	COG1914	H( )-stimulated, divalent metal cation uptake system
F3P66_RS18265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F3P66_RS18270	COG4336	lyase activity
F3P66_RS18275	COG1984	allophanate hydrolase subunit 2
F3P66_RS18280	COG4770	biotin carboxylase activity
F3P66_RS18285	COG0366	Alpha amylase catalytic
F3P66_RS18295	COG4771	TonB-dependent receptor
F3P66_RS18320	COG1414	Transcriptional regulator
F3P66_RS18325	COG1475	DNA binding
F3P66_RS18330	COG1192	Involved in chromosome partitioning
F3P66_RS18365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F3P66_RS18375	COG2986	histidine ammonia-lyase
F3P66_RS18380	COG1228	amidohydrolase
F3P66_RS18385	COG0402	S-adenosylhomocysteine deaminase activity
F3P66_RS18435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS18445	COG2423	ornithine cyclodeaminase activity
F3P66_RS18460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS18470	COG4176	ABC-type proline glycine betaine transport system permease component
F3P66_RS18480	COG4175	Glycine betaine
F3P66_RS18480	COG3448	diguanylate cyclase activity
F3P66_RS18490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS18495	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS18500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3P66_RS18525	COG0673	inositol 2-dehydrogenase activity
F3P66_RS18530	COG0673	inositol 2-dehydrogenase activity
F3P66_RS18540	COG1175	transmembrane transport
F3P66_RS18545	COG0395	ABC-type sugar transport system, permease component
F3P66_RS18550	COG3842	ATPase activity
F3P66_RS18560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F3P66_RS18565	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F3P66_RS18590	COG0583	DNA-binding transcription factor activity
F3P66_RS18595	COG0346	lactoylglutathione lyase activity
F3P66_RS18610	COG1574	metal-dependent hydrolase with the TIM-barrel fold
F3P66_RS18620	COG2814	Major facilitator Superfamily
F3P66_RS18635	COG0583	DNA-binding transcription factor activity
F3P66_RS18640	COG0477	Major facilitator Superfamily
F3P66_RS18690	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F3P66_RS18700	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F3P66_RS18705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3P66_RS18710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F3P66_RS18740	COG0010	Belongs to the arginase family
F3P66_RS18760	COG0697	spore germination
F3P66_RS18765	COG0673	inositol 2-dehydrogenase activity
F3P66_RS18785	COG0477	Major facilitator Superfamily
F3P66_RS18790	COG0642	Histidine kinase
F3P66_RS18800	COG2194	sulfuric ester hydrolase activity
F3P66_RS18805	COG0583	DNA-binding transcription factor activity
F3P66_RS18810	COG4774	siderophore transport
F3P66_RS18825	COG1120	ATPase activity
F3P66_RS18835	COG3474	cytochrome
F3P66_RS18840	COG2137	regulation of response to DNA damage stimulus
F3P66_RS18845	COG3386	PFAM SMP-30 Gluconolaconase
F3P66_RS18855	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS18860	COG1129	ABC transporter
F3P66_RS18865	COG1879	ABC-type sugar transport system periplasmic component
F3P66_RS18870	COG4585	Histidine kinase
F3P66_RS18875	COG2197	response regulator
F3P66_RS18885	COG2133	pyrroloquinoline quinone binding
F3P66_RS18895	COG0500	methyltransferase
F3P66_RS18900	COG0564	pseudouridine synthase activity
F3P66_RS18915	COG4175	Glycine betaine
F3P66_RS18915	COG0517	IMP dehydrogenase activity
F3P66_RS18920	COG4176	ABC-type proline glycine betaine transport system permease component
F3P66_RS18930	COG4191	Histidine kinase
F3P66_RS18930	COG0784	Response regulator, receiver
F3P66_RS18935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3P66_RS18940	COG3206	protein involved in exopolysaccharide biosynthesis
F3P66_RS18940	COG0489	protein tyrosine kinase activity
F3P66_RS18945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F3P66_RS18950	COG1215	transferase activity, transferring glycosyl groups
F3P66_RS18955	COG1215	transferase activity, transferring glycosyl groups
F3P66_RS18960	COG1215	transferase activity, transferring glycosyl groups
F3P66_RS18965	COG0438	transferase activity, transferring glycosyl groups
F3P66_RS18970	COG2273	Hydrolase Family 16
F3P66_RS18975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F3P66_RS18980	COG2244	polysaccharide biosynthetic process
F3P66_RS18985	COG0463	Glycosyl transferase, family 2
F3P66_RS18990	COG2327	Polysaccharide pyruvyl transferase
F3P66_RS18995	COG1215	transferase activity, transferring glycosyl groups
F3P66_RS19015	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F3P66_RS19020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS19035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F3P66_RS19035	COG0446	pyridine nucleotide-disulphide oxidoreductase
F3P66_RS19060	COG0033	Phosphoglucomutase
F3P66_RS19065	COG0297	glycogen (starch) synthase activity
F3P66_RS19070	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F3P66_RS19075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F3P66_RS19080	COG0058	SHG alpha-glucan phosphorylase activity
F3P66_RS19090	COG1794	racemase activity, acting on amino acids and derivatives
F3P66_RS19095	COG1522	sequence-specific DNA binding
F3P66_RS19105	COG2084	Dehydrogenase
F3P66_RS19110	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS19115	COG1063	alcohol dehydrogenase
F3P66_RS19125	COG4988	ABC transporter
F3P66_RS19130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F3P66_RS19140	COG1294	oxidase, subunit
F3P66_RS19170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F3P66_RS19175	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F3P66_RS19205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F3P66_RS19210	COG0539	negative regulation of cytoplasmic translation
F3P66_RS19240	COG4221	oxidoreductase activity
F3P66_RS19245	COG0006	proline dipeptidase activity
F3P66_RS19250	COG0747	negative chemotaxis
F3P66_RS19255	COG0601	transmembrane transport
F3P66_RS19260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS19265	COG0444	Belongs to the ABC transporter superfamily
F3P66_RS19270	COG4608	Belongs to the ABC transporter superfamily
F3P66_RS19285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS19310	COG0559	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS19330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F3P66_RS19335	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS19355	COG4993	Dehydrogenase
F3P66_RS19360	COG3685	Protein conserved in bacteria
F3P66_RS19390	COG0693	protein deglycase activity
F3P66_RS19410	COG0189	ligase activity
F3P66_RS19415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F3P66_RS19420	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F3P66_RS19430	COG0583	DNA-binding transcription factor activity
F3P66_RS19435	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS19440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F3P66_RS19445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3P66_RS19450	COG1116	anion transmembrane transporter activity
F3P66_RS19460	COG1522	sequence-specific DNA binding
F3P66_RS19475	COG0784	Response regulator, receiver
F3P66_RS19485	COG3920	Histidine kinase
F3P66_RS19495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F3P66_RS19510	COG0019	diaminopimelate decarboxylase activity
F3P66_RS19520	COG0513	Belongs to the DEAD box helicase family
F3P66_RS19525	COG0527	aspartate kinase activity
F3P66_RS19535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F3P66_RS19540	COG2890	protein-(glutamine-N5) methyltransferase activity
F3P66_RS19550	COG0542	response to heat
F3P66_RS19555	COG0739	heme binding
F3P66_RS19555	COG1196	nuclear chromosome segregation
F3P66_RS19555	COG0741	lytic transglycosylase activity
F3P66_RS19595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3P66_RS19605	COG2186	Transcriptional regulator
F3P66_RS19610	COG0747	negative chemotaxis
F3P66_RS19615	COG0601	transmembrane transport
F3P66_RS19620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS19625	COG4172	Belongs to the ABC transporter superfamily
F3P66_RS19665	COG1881	PFAM PEBP family protein
F3P66_RS19700	COG3833	ABC-type maltose transport systems, permease component
F3P66_RS19715	COG1278	Cold shock
F3P66_RS19725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F3P66_RS19745	COG0300	oxidoreductase activity
F3P66_RS19755	COG0446	pyridine nucleotide-disulphide oxidoreductase
F3P66_RS19755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F3P66_RS19760	COG4311	Sarcosine oxidase, delta subunit
F3P66_RS19765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS19770	COG4977	sequence-specific DNA binding
F3P66_RS19780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F3P66_RS19785	COG2218	PFAM glutamate synthase alpha subunit domain protein
F3P66_RS19790	COG0069	glutamate synthase activity
F3P66_RS19795	COG0174	glutamine synthetase
F3P66_RS19815	COG0765	amino acid transport
F3P66_RS19820	COG1126	abc transporter atp-binding protein
F3P66_RS19825	COG1454	alcohol dehydrogenase
F3P66_RS19835	COG2267	carboxylic ester hydrolase activity
F3P66_RS19845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS19850	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS19870	COG1177	transmembrane transport
F3P66_RS19875	COG3842	ATPase activity
F3P66_RS19890	COG3842	ATPase activity
F3P66_RS19895	COG0395	ABC-type sugar transport system, permease component
F3P66_RS19900	COG1175	transmembrane transport
F3P66_RS19910	COG3976	FMN-binding domain protein
F3P66_RS19910	COG1053	succinate dehydrogenase
F3P66_RS19925	COG4172	Belongs to the ABC transporter superfamily
F3P66_RS19935	COG0601	transmembrane transport
F3P66_RS19945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3P66_RS19960	COG2828	Protein conserved in bacteria
F3P66_RS19965	COG0583	DNA-binding transcription factor activity
F3P66_RS19975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3P66_RS19995	COG0494	nUDIX hydrolase
F3P66_RS20000	COG0583	DNA-binding transcription factor activity
F3P66_RS20010	COG0511	ligase activity, forming carbon-carbon bonds
F3P66_RS20015	COG0439	Biotin carboxylase
F3P66_RS20030	COG1984	allophanate hydrolase subunit 2
F3P66_RS20035	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F3P66_RS20040	COG0436	Aminotransferase
F3P66_RS20050	COG4221	oxidoreductase activity
F3P66_RS20055	COG0765	amino acid transport
F3P66_RS20060	COG0765	amino acid transport
F3P66_RS20065	COG1126	abc transporter atp-binding protein
F3P66_RS20070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS20075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F3P66_RS20090	COG0583	DNA-binding transcription factor activity
F3P66_RS20100	COG0583	DNA-binding transcription factor activity
F3P66_RS20105	COG2814	Major facilitator Superfamily
F3P66_RS20120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F3P66_RS20130	COG2207	Transcriptional regulator
F3P66_RS20135	COG0668	transmembrane transport
F3P66_RS20145	COG4566	intracellular signal transduction
F3P66_RS20165	COG0668	transmembrane transport
F3P66_RS20170	COG4191	Histidine kinase
F3P66_RS20175	COG5002	protein histidine kinase activity
F3P66_RS20175	COG0784	Response regulator, receiver
F3P66_RS20175	COG2205	protein histidine kinase activity
F3P66_RS20180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F3P66_RS20190	COG0047	phosphoribosylformylglycinamidine synthase activity
F3P66_RS20205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F3P66_RS20205	COG0446	pyridine nucleotide-disulphide oxidoreductase
F3P66_RS20215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F3P66_RS20230	COG1309	transcriptional regulator
F3P66_RS20235	COG1063	alcohol dehydrogenase
F3P66_RS20245	COG1879	ABC-type sugar transport system periplasmic component
F3P66_RS20255	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS20405	COG5001	Diguanylate cyclase
F3P66_RS20415	COG1253	flavin adenine dinucleotide binding
F3P66_RS20430	COG3842	ATPase activity
F3P66_RS20435	COG0395	ABC-type sugar transport system, permease component
F3P66_RS20440	COG1175	transmembrane transport
F3P66_RS20445	COG1653	transport
F3P66_RS20455	COG0673	inositol 2-dehydrogenase activity
F3P66_RS20460	COG1609	Transcriptional regulator
F3P66_RS20470	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS20475	COG0583	DNA-binding transcription factor activity
F3P66_RS20485	COG1879	ABC-type sugar transport system periplasmic component
F3P66_RS20490	COG1129	ABC transporter
F3P66_RS20495	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS20500	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS20505	COG1609	Transcriptional regulator
F3P66_RS20515	COG0673	inositol 2-dehydrogenase activity
F3P66_RS20575	COG0714	Associated with various cellular activities
F3P66_RS20580	COG3256	nitric oxide reductase
F3P66_RS20595	COG1845	cytochrome c oxidase, subunit III
F3P66_RS20610	COG0163	prenyltransferase activity
F3P66_RS20615	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F3P66_RS20620	COG3189	MarR family transcriptional regulator
F3P66_RS20630	COG0826	peptidase U32
F3P66_RS20685	COG0243	molybdopterin cofactor binding
F3P66_RS20695	COG3005	denitrification pathway
F3P66_RS20700	COG0583	DNA-binding transcription factor activity
F3P66_RS20710	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
F3P66_RS20715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F3P66_RS20730	COG1960	acyl-CoA dehydrogenase activity
F3P66_RS20735	COG0583	DNA-binding transcription factor activity
F3P66_RS20740	COG1609	Transcriptional regulator
F3P66_RS20750	COG1176	ABC-type spermidine putrescine transport system, permease component I
F3P66_RS20760	COG3842	ATPase activity
F3P66_RS20770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F3P66_RS20780	COG1473	amidohydrolase
F3P66_RS20795	COG0747	negative chemotaxis
F3P66_RS20800	COG0601	transmembrane transport
F3P66_RS20805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS20810	COG0444	Belongs to the ABC transporter superfamily
F3P66_RS20815	COG4608	Belongs to the ABC transporter superfamily
F3P66_RS20825	COG0583	DNA-binding transcription factor activity
F3P66_RS20830	COG0747	negative chemotaxis
F3P66_RS20840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS20845	COG0154	amidase activity
F3P66_RS20850	COG0693	protein deglycase activity
F3P66_RS20860	COG1473	amidohydrolase
F3P66_RS20865	COG4172	Belongs to the ABC transporter superfamily
F3P66_RS20870	COG2390	Transcriptional regulator
F3P66_RS20880	COG1175	transmembrane transport
F3P66_RS20885	COG0395	ABC-type sugar transport system, permease component
F3P66_RS20900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F3P66_RS20905	COG1069	ribulokinase activity
F3P66_RS20910	COG1737	Transcriptional regulator
F3P66_RS20930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F3P66_RS20950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F3P66_RS20955	COG1414	Transcriptional regulator
F3P66_RS20960	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS20970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F3P66_RS20975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F3P66_RS20980	COG1121	(ABC) transporter
F3P66_RS20985	COG0803	Belongs to the bacterial solute-binding protein 9 family
F3P66_RS20995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F3P66_RS21000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F3P66_RS21005	COG0471	metal ion transport
F3P66_RS21005	COG3273	potassium ion transport
F3P66_RS21010	COG1253	flavin adenine dinucleotide binding
F3P66_RS21015	COG1309	transcriptional regulator
F3P66_RS21035	COG1609	Transcriptional regulator
F3P66_RS21040	COG1070	Carbohydrate kinase
F3P66_RS21045	COG2115	Belongs to the xylose isomerase family
F3P66_RS21055	COG0778	Nitroreductase
F3P66_RS21060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F3P66_RS21065	COG2011	ABC-type metal ion transport system permease component
F3P66_RS21075	COG5001	Diguanylate cyclase
F3P66_RS21075	COG3300	MHYT domain
F3P66_RS21080	COG1054	Belongs to the UPF0176 family
F3P66_RS21090	COG2954	triphosphatase activity
F3P66_RS21095	COG0800	Aldolase
F3P66_RS21115	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
F3P66_RS21135	COG0523	cobalamin synthesis protein
F3P66_RS21145	COG1846	Transcriptional regulator
F3P66_RS21150	COG1609	Transcriptional regulator
F3P66_RS21155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F3P66_RS21160	COG0673	inositol 2-dehydrogenase activity
F3P66_RS21165	COG3718	enzyme involved in inositol metabolism
F3P66_RS21175	COG3962	Belongs to the TPP enzyme family
F3P66_RS21180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3P66_RS21195	COG0411	ABC transporter
F3P66_RS21210	COG0683	leucine binding
F3P66_RS21230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS21240	COG0747	negative chemotaxis
F3P66_RS21255	COG1082	Xylose isomerase domain protein TIM barrel
F3P66_RS21255	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F3P66_RS21265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F3P66_RS21270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F3P66_RS21275	COG1126	abc transporter atp-binding protein
F3P66_RS21280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS21285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS21290	COG0765	amino acid transport
F3P66_RS21295	COG0765	amino acid transport
F3P66_RS21305	COG3485	protocatechuate 3,4-dioxygenase
F3P66_RS21310	COG3485	protocatechuate 3,4-dioxygenase
F3P66_RS21315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3P66_RS21325	COG0583	DNA-binding transcription factor activity
F3P66_RS21340	COG1414	Transcriptional regulator
F3P66_RS21350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F3P66_RS21355	COG0183	Belongs to the thiolase family
F3P66_RS21360	COG1609	Transcriptional regulator
F3P66_RS21380	COG0673	inositol 2-dehydrogenase activity
F3P66_RS21390	COG1609	Transcriptional regulator
F3P66_RS21395	COG0395	ABC-type sugar transport system, permease component
F3P66_RS21400	COG1175	transmembrane transport
F3P66_RS21405	COG3842	ATPase activity
F3P66_RS21415	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
F3P66_RS21435	COG1940	carbohydrate kinase activity
F3P66_RS21445	COG3842	ATPase activity
F3P66_RS21450	COG4149	molybdate abc transporter
F3P66_RS21460	COG0584	glycerophosphoryl diester phosphodiesterase
F3P66_RS21465	COG0483	inositol monophosphate 1-phosphatase activity
F3P66_RS21470	COG0300	oxidoreductase activity
F3P66_RS21490	COG3842	ATPase activity
F3P66_RS21510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F3P66_RS21545	COG0667	Aldo Keto reductase
F3P66_RS21550	COG0583	DNA-binding transcription factor activity
F3P66_RS21560	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3P66_RS21570	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS21580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F3P66_RS21595	COG1132	(ABC) transporter
F3P66_RS21630	COG1215	transferase activity, transferring glycosyl groups
F3P66_RS21645	COG1215	transferase activity, transferring glycosyl groups
F3P66_RS21655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F3P66_RS21660	COG1091	dTDP-4-dehydrorhamnose reductase activity
F3P66_RS21665	COG1088	dTDP-glucose 4,6-dehydratase activity
F3P66_RS21670	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
F3P66_RS21685	COG0444	Belongs to the ABC transporter superfamily
F3P66_RS21690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS21695	COG0601	transmembrane transport
F3P66_RS21700	COG2186	Transcriptional regulator
F3P66_RS21705	COG1312	Catalyzes the dehydration of D-mannonate
F3P66_RS21710	COG0747	negative chemotaxis
F3P66_RS21720	COG5001	Diguanylate cyclase
F3P66_RS21720	COG3300	MHYT domain
F3P66_RS21725	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS21735	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F3P66_RS21750	COG1392	Phosphate transport regulator
F3P66_RS21775	COG5002	protein histidine kinase activity
F3P66_RS21790	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F3P66_RS21805	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS21820	COG3119	arylsulfatase activity
F3P66_RS21825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3P66_RS21830	COG3842	ATPase activity
F3P66_RS21835	COG0165	Argininosuccinate lyase
F3P66_RS21840	COG0395	ABC-type sugar transport system, permease component
F3P66_RS21845	COG1175	transmembrane transport
F3P66_RS21850	COG2182	Extracellular solute-binding protein
F3P66_RS21855	COG1940	carbohydrate kinase activity
F3P66_RS21880	COG1486	melibiose metabolic process
F3P66_RS21885	COG0747	negative chemotaxis
F3P66_RS21890	COG0601	transmembrane transport
F3P66_RS21895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS21900	COG4172	Belongs to the ABC transporter superfamily
F3P66_RS21905	COG1486	melibiose metabolic process
F3P66_RS21910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F3P66_RS21915	COG0842	Transport permease protein
F3P66_RS21915	COG1129	ABC transporter
F3P66_RS21935	COG0784	Response regulator, receiver
F3P66_RS21940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F3P66_RS21950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3P66_RS21955	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F3P66_RS21970	COG0765	amino acid transport
F3P66_RS21980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3P66_RS21990	COG3938	Belongs to the proline racemase family
F3P66_RS22005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS22010	COG0765	amino acid transport
F3P66_RS22015	COG0765	amino acid transport
F3P66_RS22025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F3P66_RS22040	COG0402	S-adenosylhomocysteine deaminase activity
F3P66_RS22050	COG0601	transmembrane transport
F3P66_RS22055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS22065	COG0402	S-adenosylhomocysteine deaminase activity
F3P66_RS22070	COG0444	Belongs to the ABC transporter superfamily
F3P66_RS22075	COG4608	Belongs to the ABC transporter superfamily
F3P66_RS22080	COG1802	Transcriptional regulator
F3P66_RS22085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F3P66_RS22110	COG3383	formate dehydrogenase (NAD+) activity
F3P66_RS22120	COG2223	nitrite transmembrane transporter activity
F3P66_RS22150	COG3237	CsbD-like
F3P66_RS22155	COG2197	response regulator
F3P66_RS22160	COG2186	Transcriptional regulator
F3P66_RS22165	COG0747	negative chemotaxis
F3P66_RS22170	COG0601	transmembrane transport
F3P66_RS22175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS22180	COG0405	Gamma-glutamyltransferase
F3P66_RS22190	COG3237	CsbD-like
F3P66_RS22200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F3P66_RS22205	COG3181	Tripartite tricarboxylate transporter family receptor
F3P66_RS22210	COG5265	(ABC) transporter
F3P66_RS22215	COG0488	(ABC) transporter
F3P66_RS22240	COG1049	propionate catabolic process, 2-methylcitrate cycle
F3P66_RS22245	COG0840	transmembrane signaling receptor activity
F3P66_RS22255	COG0110	maltose O-acetyltransferase activity
F3P66_RS22265	COG1063	alcohol dehydrogenase
F3P66_RS22270	COG3284	Transcriptional regulator
F3P66_RS22290	COG1129	ABC transporter
F3P66_RS22295	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS22300	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS22315	COG1082	Xylose isomerase domain protein TIM barrel
F3P66_RS22325	COG1126	abc transporter atp-binding protein
F3P66_RS22330	COG0765	amino acid transport
F3P66_RS22335	COG0765	amino acid transport
F3P66_RS22340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS22345	COG3608	succinylglutamate desuccinylase aspartoacylase
F3P66_RS22350	COG0006	proline dipeptidase activity
F3P66_RS22355	COG2423	ornithine cyclodeaminase activity
F3P66_RS22360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F3P66_RS22365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3P66_RS22370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3P66_RS22375	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS22380	COG1522	sequence-specific DNA binding
F3P66_RS22390	COG3046	protein related to deoxyribodipyrimidine photolyase
F3P66_RS22435	COG4566	intracellular signal transduction
F3P66_RS22445	COG0243	molybdopterin cofactor binding
F3P66_RS22450	COG0783	Belongs to the Dps family
F3P66_RS22470	COG4191	Histidine kinase
F3P66_RS22470	COG0784	Response regulator, receiver
F3P66_RS22480	COG1840	ABC-type Fe3 transport system, periplasmic component
F3P66_RS22485	COG1840	ABC-type Fe3 transport system, periplasmic component
F3P66_RS22495	COG3842	ATPase activity
F3P66_RS22500	COG0483	inositol monophosphate 1-phosphatase activity
F3P66_RS22515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F3P66_RS22540	COG2197	response regulator
F3P66_RS22545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F3P66_RS22550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F3P66_RS22560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
F3P66_RS22565	COG4310	Domain of unknown function (DUF2172)
F3P66_RS22570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F3P66_RS22580	COG2197	response regulator
F3P66_RS22585	COG4566	intracellular signal transduction
F3P66_RS22615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F3P66_RS22635	COG0438	transferase activity, transferring glycosyl groups
F3P66_RS22650	COG1522	sequence-specific DNA binding
F3P66_RS22685	COG1414	Transcriptional regulator
F3P66_RS22695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F3P66_RS22715	COG0582	viral genome integration into host DNA
F3P66_RS22735	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F3P66_RS22765	COG1349	DNA-binding transcription factor activity
F3P66_RS22770	COG1879	ABC-type sugar transport system periplasmic component
F3P66_RS22775	COG1129	ABC transporter
F3P66_RS22780	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS22785	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS22805	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS22880	COG1846	Transcriptional regulator
F3P66_RS22900	COG0667	Aldo Keto reductase
F3P66_RS22995	COG1475	DNA binding
F3P66_RS23000	COG1192	Involved in chromosome partitioning
F3P66_RS23025	COG2207	Transcriptional regulator
F3P66_RS23045	COG1566	PFAM secretion protein HlyD family protein
F3P66_RS23055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F3P66_RS23105	COG3920	Histidine kinase
F3P66_RS23130	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS23170	COG1278	Cold shock
F3P66_RS23190	COG4191	Histidine kinase
F3P66_RS23190	COG0784	Response regulator, receiver
F3P66_RS23230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F3P66_RS23240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F3P66_RS23245	COG2080	2 iron, 2 sulfur cluster binding
F3P66_RS23250	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F3P66_RS23255	COG1309	transcriptional regulator
F3P66_RS23265	COG3685	Protein conserved in bacteria
F3P66_RS23280	COG0753	catalase activity
F3P66_RS23325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS23330	COG0765	amino acid transport
F3P66_RS23340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3P66_RS23345	COG4948	Mandelate Racemase Muconate Lactonizing
F3P66_RS23350	COG0006	proline dipeptidase activity
F3P66_RS23355	COG0504	CTP synthase activity
F3P66_RS23385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F3P66_RS23400	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS23405	COG1414	Transcriptional regulator
F3P66_RS23410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F3P66_RS23415	COG3842	ATPase activity
F3P66_RS23420	COG0395	ABC-type sugar transport system, permease component
F3P66_RS23425	COG1175	transmembrane transport
F3P66_RS23435	COG4948	Mandelate Racemase Muconate Lactonizing
F3P66_RS23440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3P66_RS23445	COG3734	2-keto-3-deoxy-galactonokinase
F3P66_RS23475	COG0071	Belongs to the small heat shock protein (HSP20) family
F3P66_RS23480	COG3831	ATPase activity
F3P66_RS23490	COG0596	Alpha beta hydrolase
F3P66_RS23495	COG1902	pentaerythritol trinitrate reductase activity
F3P66_RS23500	COG4221	oxidoreductase activity
F3P66_RS23510	COG0840	transmembrane signaling receptor activity
F3P66_RS23530	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS23540	COG1082	Xylose isomerase domain protein TIM barrel
F3P66_RS23545	COG0673	inositol 2-dehydrogenase activity
F3P66_RS23550	COG1082	Xylose isomerase domain protein TIM barrel
F3P66_RS23555	COG1609	Transcriptional regulator
F3P66_RS23595	COG2072	flavoprotein involved in K transport
F3P66_RS23600	COG3842	ATPase activity
F3P66_RS23605	COG1177	transmembrane transport
F3P66_RS23620	COG0583	DNA-binding transcription factor activity
F3P66_RS23640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F3P66_RS23650	COG1177	transmembrane transport
F3P66_RS23665	COG3842	ATPase activity
F3P66_RS23670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS23675	COG0765	amino acid transport
F3P66_RS23685	COG2186	Transcriptional regulator
F3P66_RS23695	COG0583	DNA-binding transcription factor activity
F3P66_RS23705	COG1012	belongs to the aldehyde dehydrogenase family
F3P66_RS23730	COG0673	inositol 2-dehydrogenase activity
F3P66_RS23735	COG0667	Aldo Keto reductase
F3P66_RS23745	COG1376	ErfK ybiS ycfS ynhG family protein
F3P66_RS23755	COG0789	Transcriptional regulator
F3P66_RS23765	COG0673	inositol 2-dehydrogenase activity
F3P66_RS23770	COG2267	carboxylic ester hydrolase activity
F3P66_RS23785	COG0583	DNA-binding transcription factor activity
F3P66_RS23790	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS23795	COG0583	DNA-binding transcription factor activity
F3P66_RS23805	COG1063	alcohol dehydrogenase
F3P66_RS23810	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS23820	COG1136	(ABC) transporter
F3P66_RS23820	COG0577	efflux transmembrane transporter activity
F3P66_RS23825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F3P66_RS23835	COG0745	RESPONSE REGULATOR receiver
F3P66_RS23850	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
F3P66_RS23855	COG2948	multi-organism process
F3P66_RS23860	COG3504	Conjugal transfer protein
F3P66_RS23865	COG3736	Type IV secretory pathway, component VirB8
F3P66_RS23875	COG3704	protein secretion by the type IV secretion system
F3P66_RS23890	COG3451	type IV secretory pathway VirB4
F3P66_RS23895	COG3702	type iv secretory pathway
F3P66_RS23900	COG3838	Conjugal transfer protein Trbc
F3P66_RS23940	COG1733	regulation of RNA biosynthetic process
F3P66_RS23960	COG1285	pathogenesis
F3P66_RS23990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F3P66_RS23995	COG1454	alcohol dehydrogenase
F3P66_RS24005	COG1414	Transcriptional regulator
F3P66_RS24030	COG1177	transmembrane transport
F3P66_RS24040	COG3842	ATPase activity
F3P66_RS24060	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS24065	COG0745	RESPONSE REGULATOR receiver
F3P66_RS24075	COG0745	RESPONSE REGULATOR receiver
F3P66_RS24080	COG0156	8-amino-7-oxononanoate synthase activity
F3P66_RS24130	COG3505	Type IV secretory pathway VirD4
F3P66_RS24135	COG3831	ATPase activity
F3P66_RS24150	COG5489	Protein of unknown function (DUF736)
F3P66_RS24225	COG3920	Histidine kinase
F3P66_RS24270	COG1609	Transcriptional regulator
F3P66_RS24280	COG3395	kinase activity
F3P66_RS24290	COG1454	alcohol dehydrogenase
F3P66_RS24295	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F3P66_RS24305	COG0747	negative chemotaxis
F3P66_RS24310	COG0601	transmembrane transport
F3P66_RS24315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS24325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3P66_RS24340	COG1846	Transcriptional regulator
F3P66_RS24345	COG1737	Transcriptional regulator
F3P66_RS24350	COG3842	ATPase activity
F3P66_RS24360	COG0395	ABC-type sugar transport system, permease component
F3P66_RS24365	COG1175	transmembrane transport
F3P66_RS24400	COG0071	Belongs to the small heat shock protein (HSP20) family
F3P66_RS24475	COG3177	Filamentation induced by cAMP protein fic
F3P66_RS24535	COG0210	DNA helicase
F3P66_RS24540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F3P66_RS24625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3P66_RS24630	COG1126	abc transporter atp-binding protein
F3P66_RS24645	COG0640	Transcriptional regulator
F3P66_RS24650	COG1475	DNA binding
F3P66_RS24655	COG1192	Involved in chromosome partitioning
F3P66_RS24700	COG1566	PFAM secretion protein HlyD family protein
F3P66_RS24755	COG5314	conjugation
F3P66_RS24765	COG3846	protein secretion by the type IV secretion system
F3P66_RS24770	COG3701	Conjugal transfer protein
F3P66_RS24820	COG0583	DNA-binding transcription factor activity
F3P66_RS24870	COG3436	PFAM IS66 Orf2 family protein
F3P66_RS25015	COG3161	chorismate lyase activity
F3P66_RS25075	COG0483	inositol monophosphate 1-phosphatase activity
F3P66_RS25080	COG0584	glycerophosphoryl diester phosphodiesterase
F3P66_RS25085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS25120	COG1283	sodium-dependent phosphate transmembrane transporter activity
F3P66_RS25210	COG5489	Protein of unknown function (DUF736)
F3P66_RS25215	COG0494	nUDIX hydrolase
F3P66_RS25240	COG5489	Protein of unknown function (DUF736)
F3P66_RS25260	COG2824	Alkylphosphonate utilization operon protein PhnA
F3P66_RS25280	COG1475	DNA binding
F3P66_RS25365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F3P66_RS25370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS25380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F3P66_RS25390	COG0583	DNA-binding transcription factor activity
F3P66_RS25395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS25410	COG0601	transmembrane transport
F3P66_RS25415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F3P66_RS25420	COG4172	Belongs to the ABC transporter superfamily
F3P66_RS25445	COG1129	ABC transporter
F3P66_RS25450	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3P66_RS25480	COG1028	Short-chain dehydrogenase reductase Sdr
F3P66_RS25485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F3P66_RS25495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F3P66_RS25500	COG1116	anion transmembrane transporter activity
F3P66_RS25515	COG0583	DNA-binding transcription factor activity
F3P66_RS25560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F3P66_RS25565	COG0640	Transcriptional regulator
F3P66_RS25570	COG1475	DNA binding
F3P66_RS25575	COG1192	Involved in chromosome partitioning
F3P66_RS25585	COG4962	Type ii secretion system protein e
F3P66_RS25605	COG5314	conjugation
F3P66_RS25615	COG3846	protein secretion by the type IV secretion system
F3P66_RS25620	COG3701	Conjugal transfer protein
F3P66_RS25670	COG0583	DNA-binding transcription factor activity
F3P66_RS25720	COG3436	PFAM IS66 Orf2 family protein