locus-tag	class	description
KNU99_gp006	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KNU99_gp022	COG0417	DNA replication proofreading
KNU99_gp040	COG2176	DNA-directed DNA polymerase activity
KNU99_gp073	COG1793	dna ligase
KNU99_gp084	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KNU99_gp091	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KNU99_gp109	COG3750	Belongs to the UPF0335 family
KNU99_gp157	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KNU99_gp221	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KNU99_gp221	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes